Conference Series LLC Ltdinvites you for 14thInternational Conference on Metabolomics and Enzymology during March 18-19, 2019 New York, USA. This is a fabulous open door for the representatives from Universities and Institutes to communicate with the world-class Scientists.
Theme: Focuses on the development of Metabolomics
Metabolomics Meeting 2019conference will be an investigation of New Research Innovations in Metabolomics and a spread of the most recent advancements and methodologies in Metabolomics displaying, Proteomics, Systems Biology, Genomics, Precision Medicine, Lipidomics, LC-MS and GC-MS Techniques, Bioinformatics, Plant Metabolomics, Clinical metabolomics, computational science, metabolomic disorders, Nutritional Metabolomics, Therapeutic Metabolomics and more. Metabolomics is of enthusiasm to clinicians in light of the fact that it might prompt enhancements in the conclusion and medications of human illnesses. Metabolomics makes utilization of systematic procedures, for example, spectroscopy, chromatography, and multivariable investigation.Metabolomicspermits researchers to improve knowledge and to help devise effective methods of health research.
Conference Series llc LTDOrganizes 1000+Global Eventsevery Year across USA, Europe & Asia with support from 1000 morescientific societiesand Publishes 700+Open access journalswhich contains over 100000 eminent personalities, reputed scientists as editorial board and organizing committee members. TheConference Series LLC Ltdwebsite will provide you list and details about the conferences organizing worldwide.
Target Audience will be personnel from both industrial and academic fields which include; CEOs, COOs, Directors, Vice Presidents, Co-directors, Biochemists, Biotechnologists, Managing Directors, Industry Safety Officers, Environmental & Plant Scientists, Doctorates, Professors, Post Doctorate Fellows, Vendors of Consumer Products/ Managers, Pharmaceutical Scientists, Students from the related fields.
Track 1:Cancer Therapeutic Approaches
Cancer cells are known to possess a highly uniquemetabolic phenotype. Hence development of specific biomarkers in oncology is necessary and they are used to detect the presence of cancer, determine prognosis, and/or assess the viability of treatment. Recent innovations have empowered the examination of numerouspotential biomarkersand recharged enthusiasm for growing new biomarkers. Metabolomics allows for a global assessment of a cellular state within the context of the immediate environment, considering genetic regulation, altered kinetic activity of enzymes, and changes in metabolic reactions. Thus, Metabolomics is growing in the field of oncology with particular attention to its application as a biomarker incancer diagnosis, assessing treatment effects, and in the development of noveltherapeutics.
1.1 Role of NMR based metabolomics in Cancer
1.2 Use of metabolomics in Cancer Biomarker discovery
1.3 Applications of metabolomics in Cancer studies
1.4 Future of metabolomics in Oncology
Track 2:Metabolomics in Precision Medicine
Precision medicine is an approach to manage finding exact solutions to fathom the natural reason of infection.Precision medicineis a rising methodology for illness treatment. Accuracy offers cutting edge answers for augment your achievement in translational examination.Pharmacometabolomics,an emerging field in metabolomics, plays a key role in precision medicine.
2.1 Role of metabolomics in Precision medicine
2.2 Novel biomarkers for Precision medicine
2.3 Novel applications of Metabolomics in drug discovery
Track 3:Therapeutic Metabolomics
Metabolomics had profound importance in recent years in context to its applications in the field of drug discovery and drug development. With recent advances in the field ofmetabolomicsit can be proved as a major tool for innovative therapeutic discoveries. In the agricultural/chemical industry, metabolomics may be used to develop herbicides and pesticides. With increasing importance being placed on health and safety related aspects of our food, metabolomics can potentially be a valuable tool infood processingand quality control, or in plant breeding for improved crop varieties and in the development of novel food stuffs.Centre for Metabolomicsis associated with therapeutic metabolomics.Computational immunologyis a field of science that incorporates high-throughput genomic andbioinformaticsways to deal with immunology.
3.1 Drug target discovery
3.2 Strategies in biomarker discovery
3.3 Metabolomics an innovative tool for novel therapeutics.
Track 4:Metabolic Profiling
Metabolic profiling is an assessment of low-molecular-weight metabolites and their intermediates in unicellular to multicellular biological systems that reflects the dynamic response togenetic modification. The measurement and evaluation of the endogenousmetabolite profilefrom a biological sample have provided many opportunities to investigate the changes induced by external stimuli. Metabolomic profiling has been used to recognize novel biomarkers and instruments ofcardiovascularhazard. Metabolomic approach gives novel encounters into the robotic investigations of tumour diagnosis. Metabolic profiling can supplement routine frameworks and other "omics" propels in inquiring about preclinical prescription change issues.
4.1 Biomolecule profiling for the diagnosis of inborn errors of metabolism
4.2 Targeted metabolite profiling
4.3 High throughput metabolite profiling
4.4 NMR based drug metabolite profiling
4.5 Current challenges in metabolite profiling technologies
The biological processes between different levels of omics are highly complex, a combined analysis ofmetaboliteand gene expression data will help discover and evaluate the underlying pathway mechanisms and identify genes that influence the metabolome.Transcriptomicstudies measure the simultaneous expression of up to thousands of genes and can be used to identify which genes are up- or down-regulated under certain conditions. Metabolomic studies provide information on the metabolites found within a biological sample. These two branches seek to uncover the underlying systems biology and when combined they can be successful in predictinggene functionsor identifyinggene-metabolite associations.
5.1 Integration of transcriptomics & metabolomics
5.2 Potential of metabolomics as a functional genomics tool.
The pivotal role of lipids in cell, tissue and organphysiologyis demonstrated by a large number of genetic studies and by many human diseases that involve the disruption of lipidmetabolic enzymesand pathways. Examples of such diseases include cancer, diabetes, as well asneurodegenerativeand infectious diseases. So far, the outbreak of information in the fields of genomics and proteomics has not been matched by a corresponding advancement of knowledge in the field of lipids, which is largely due to the complexity of lipids and the lack of powerful tools for their analysis. Novel analytical approaches mainly LC and MS for system-level analysis of lipids and their interacting partners now make this field a promising area of biomedical research, with a variety of applications in drug andbiomarkerdevelopment. Mass spectrometry, largely due to its analytical power and rapid development of new instruments and techniques, has been widely used inlipidomics.
6.1 Analytical techniques in Lipidomics
6.2 Lipidomics & risk of Cardiovascular diseases and diabetes
6.3 Lipid profiling and its potential applications
6.4 Statistical analysis of Lipidomics.
Track 7:Metabolic Modelling
Metabolic modelling allows a deep insight into the molecular mechanisms of a particular organism.A reconstruction process breaks downmetabolic pathways into their respective reactions and enzymes, and analyses them within the perspective of the entire network. It collects all the relevant metabolic information of an organism and compiles it in amathematical model. A deep analysis of these reconstructed pathways can allow identification of key features of metabolism such as growth yield, resource distribution, networkrobustness, and gene essentiality. This information can then be applied to create novel biotechnological methods.
7.1 Molecular modelling methods in metabolomics
7.2 Computational approaches for metabolic modelling
7.3 Qualitative modelling of metabolic networks.
Track 8:Clinical Metabolomics
Conventional biological diagnostic procedures are based on a time-consuming series of sequential biochemical tests. The rise of omic technologies offers the complete picture of basic molecules that build a biological system at different levels.Metabolomicsis the most recent omic technology based on biochemical characterization of metabolites and their changes pertaining togeneticand environmental factors.Metabolomics, when used as a translational research tool, can offer a link between the laboratory and clinic, and produce results in a lesser time.
8.1 Challenges & developments in clinical metabolomics
8.2 Clinical applications of metabolomics in diabetes treatment
8.3 Clinical risk prediction using metabolomics
Track 9:Plant Metabolomics
Metabolomics is the examination of endogenous and exogenous low atomic mass metabolites inside of a cell, tissue, or biofluid of a life form in light of an outer stressor. Plant Metabolomicsis to contemplate the plant framework at the sub-atomic level giving complete characterization of metabolome of plants under particular conditions. Using Metabolomics, a better understanding of the correlation between genes and thebiochemical compositionof a plant tissue in response to its environment can be obtained, and this information can be further used to assess gene function.
9.1 Plant metabolic network
9.2 Application of LC-MS in plant metabolomics
Track 10:Nutritional Metabolomics
Metabolomics has been emerged as a significant tool in many disciplines. In food science, metabolomics has recently risen as a tool for quality, processing and safety of raw materials and final products.Nutrigenomicsprovides a gateway to study the effect of foods and food constituents on gene expression. Applications of nutrigenomics include the genomic,transcriptomic, proteomic, andmetabolomic studyof foods for compoundprofiling, authenticity related to food safety; the development of newtransgenicfoods, food contaminants, and whole toxicity studies; new investigations on food bioactivity, food effects on human health.
10.1 Emerging role of metabolomics in human nutrition
10.2 Metabolomics in Plant nutrition Emerging methodologies
10.3 Food metabolome and its signature in Human samples
10.4 Recent advances in nutritional metabolomics
10.5 Future of nutritional metabolomics & research needs
Track 11:Metabolomic databases
Metabolomics relies on a variety ofbioinformatictools aiming to derive information from data. Data acquisition with chromatography-coupled mass spectrometry yields high volumes of raw data that need to be processed to achieve proper biochemical data that eventually can be presented for statistics and pathway analysis in a coherent manner. A variety of new tools andalgorithmshave recently been developed that help in this process. If cutting-edge methods are used, we can confidently interpret signals that can neither be identified by reference standards and are used for novel researches.
11.1 Human metabolome database
11.2 Databases and software for metabolomic studies
Track 12:Analytical Metabolomics
To obtain holistic metabolic profiles from complex samples, such as biological fluids or tissue extracts, we require a powerful, high resolution and information richanalytical methodsand for this,spectroscopic technologiesare generally used. Mass spectrometry, coupled to liquid chromatography (LCMS), is increasingly being used for such investigations as a result of the significant advances in both technologies over the past decade.
12.1 Modern analytical techniques in metabolomic analysis
12.2 Applications of NMR based metabolomics
12.3 Recent advances in NMR based metabolomics
Xenobiotics are encountered by humans on a daily basis and include drugs, environmental pollutants, cosmetics, and even components of the diet. These chemicals undergo metabolism anddetoxicationto produce numerous metabolites, some of which have the potential to cause adverse effects such as toxicity. They can also block the action of enzymes or receptors used for endogenous metabolism or affect theefficacyof a co-administered drug. Therefore, it is essential to determine the full metabolic effects that these chemicals have on the body. Metabolomics, the comprehensive analysis of small molecules in a biofluid, can reveal biologically relevant perturbations that result fromxenobioticexposure.
13.1 Challenges and Opportunities of xenobiotics in metabolomics
13.2 Profiling the reactive metabolites of xenobiotics using metabolomic technologies.
13.3 Metabolomics as a global biochemical approach to drug response and disease
Track 14:Metabolomics & Biotechnology
By studying the complete set of metabolites within a microorganism and monitoring its interactions between its development processes and the environment, metabolomics can potentially provide a more accurate picture of the actual physiological state of the cell.Microbial metabolomicshas received much attention in recent years mainly because it supports and complements a wide range of microbial research areas from new drug discovery efforts tometabolic engineering.
14.1 Microbial metabolomics with higher throughput
14.2 Custom made separation for microbial metabolomics
14.3 Application of microbial metabolomics
Track 15:Metabolomics & Pharmacology
Pharmacogenomics has some impact in clinical practice, through its use to select patient subgroups who will enjoy efficacy without side effects when treated with certain drugs. However,pharmacogenomics, has had less impact than initially predicted. One reason for this is that many diseases, and the way in which the patients respond to drug treatments, have both genetic and environmental elements. Puregenomicsis almost blind to the environmental elements. A new methodology has emerged, termedpharmacometabolomicsthat is concerned with the prediction of drug effects through the analysis of pre-dose, biofluid metabolite profiles, which reflect both genetic and environmental influences on human physiology.
15.1 Implications of Clinical Pharmacology
15.2 Pharmaceutical research & Metabolomics in the New born
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