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Category Archives: Anti-Aging Medicine
Whether you've recently noticed a few new wrinkles on your face or are suddenly feeling significantly older than your chronological age, there are countless reasons you might be looking to turn back the clock. However, even if you haven't exactly found the fountain of youth, you can both look and feel younger with just a few small changes to your routine. Read on to discover the anti-aging supplements recommended by registered dietitians. And for more supplements you may want to add to your routine, check out The One Vitamin Doctors Are Urging Everyone to Take Right Now.
Curcumin, a yellow compound found in turmeric, is a great way to fight free radical damage that leads to aging.
"Aging happens over time as our cells are exposed to free radicals and inflammation. When this happens, the structures involved in cell replication and lifespantelomeresshorten, so anything that can reduce inflammation and free radicals is helpful," says Alicia Galvin, RD, resident dietitian to Sovereign Laboratories.
"Curcumin activates certain proteins, like AMP-activated protein kinase (AMPK), which helps combat cellular damage and promotes longevity."
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Want to lose weight and turn back the clock in one fell swoop? Then you might want to add some EGCG to your diet.
"Epigallocatechin gallate (EGCG) is a polyphenol concentrated in green tea," Galvin explains. "It induces autophagy, the process by which your body removes damaged cellular material."
What's more, in a small study of 73 overweight and obese women published in BMC Complementary Medicine and Therapies, EGCG was found to reduce LDL or "bad" cholesterol and increase levels of leptin, a hormone associated with satiety.
If you want to look and feel younger, CoQ10 supplementation might just do the trick.
"CoQ10 declines as you age, and CoQ10 supplements help reduce the accumulation of free radicals that accelerate the aging process," Galvin says.
And if you want to protect your health, These Popular Supplements Have Hidden Dangers, Warn Experts.
Adding some resveratrola compound found in a number of red wine, red fruits, and peanuts, among other foodsto your regular routine is a great way to fight aging from the inside out.
"Resveratrol may promote longevity by activating genes called sirtuins," Galvin says. "This doesn't mean you can drink red wine and not age, but as a supplement, resveratrol can be very effective."
If you do like to wind down with wine at the end of the day, check out the One Surprising Side Effect of Drinking Red Wine for Women, Says New Study.
Vitamin D, a vitamin naturally synthesized through the skin by exposure to sunlight, can have profound anti-aging benefits in supplement form.
"Vitamin D allows the body to absorb calcium, which fuels bone health and may reduce the risk for fracture," says Diana Gariglio-Clelland, RD, a dietitian with Next Luxury.
Citing 2015 research published in the Journal of Advanced Research, Gariglio-Clelland notes that vitamin D has also been linked to reduced UV damage.
If you're eager to keep your body and brain healthy as you age, fish oil supplements are an excellent addition to your wellbeing arsenal.
"Fish oil supplements contain omega-3 fatty acids, known to protect our heart health and cognition, both of which are essential as we age," says Michelle Darian, MS, MPH, RD, a nutrition scientist at InsideTracker.
And for more easy ways to boost your brainpower, check out the 30 Best & Worst Foods for Your Brain.
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Best Supplements That Fight Aging, According to Experts - Eat This, Not That
Recent findings from a scientific study may just have discovered the holy grail of health. As confirmed by TRC Gen+, a recent study from Prof. Nikolaos Tzenios PH.D. has pinpointed the healthy diet plan which brings down bodyweight and boosts cardiovascular health markers. Head of the study, Prof Tzenios, is a respected industry professional and holds positions as Professor of Public Health, Fellow of the American Academy of Anti-Aging Medicine and Fellow of The Royal Society for Public Health (UK), among other high-level roles.
An open-label clinical study conducted by the well-regarded KGK Science Canada organisation explored the impact of Nics Keto Diet on cardiovascular health. The study looked at healthy women and men who had slightly elevated LDL cholesterol measurements for a 140 day period. On completion of the clinical study, KGK Science found that participants had a 4.41% lowering in the percentage of body fat.
Results also showed that those who had taken part in the study had seen an 8.55kg reduction in body weight overall. In addition, participants also recorded a significant drop in LDL and total cholesterol readings, after following the diet for 5 months. There was also an increase in good HDL cholesterol levels and an impressive drop in blood sugar levels.
In summary, the study from KGK Science indicates that following Nics Keto Diet could help to lower body weight, boost cardiovascular health, lower bad cholesterol levels and reduce blood sugar levels. As a result, its findings are sure to make waves in the health and nutrition sector.
Jenny has been reporting on small business issues since 2001 where she held a number of freelance positions across the leading SME publications in the UK. Specialist subjects included SME financing and tax.
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Following a Nic's Keto Diet may improve cardiovascular health and reduce body weight - SMEbulletin
Eating a Nic’s Keto Healthy Fatty Diet Reduce Body Weight and Improve Cardiovascular Health Markers! – Yahoo Finance
(Bloomberg) -- The cyber-attack that crippled the nations biggest fuel pipeline this week triggered spot shortages of gasoline and a gusher of political rhetoric, with groups from across the political spectrum offering myriad, and contradictory, solutions.The oil industry says the answer is to invest in more fossil-fuel infrastructure, including refineries. Environmental groups think the key is more electric vehicles on the road and solar panels on the grid. A conservative think tank called the outage a wake-up call for pipeline protesters to stop. Even a coal group got involved, noting that its product doesnt need to be piped anywhere.Wind and solar power networks are by their very nature more distributed, more sensibly scaled, and more resilient than fossil fuel systems, Wenonah Hauter, executive director of the environmental group Food and Water Watch, said in a statement.The stark divisions reflect the increasingly vocal energy debate. The oil and gas industry has found itself on the defensive against growing calls to fight climate change by reducing consumption of its products. While many fossil fuel advocates agree that curbing greenhouse gases is critical, they point to the Colonial shutdown as a sign of the potential risks of making the green transition too quickly.Colonial Pipeline Co. began to restart the line Wednesday evening, after a ransomware attack caused the company to shut it down May 7. The pipeline delivers about 45% of the gasoline, jet fuel and diesel used on the East Coast.Whew, crisis averted, that pipeline is back up, tweeted Chris Horner, an attorney and former senior fellow at the Competitive Enterprise Institute. Now, back to our regularly scheduled agenda of shutting down pipelines.Conservatives have drawn links between the Colonial outage that transported refined fuels and President Joe Bidens opposition to the proposed Keystone XL oil pipeline that would have ferried tar sands crude from Alberta to Nebraska. Even a fully operational Keystone XL would have had no effect on fuel supplies during the Colonial outage, since it would carry minimally processed crude, not gasoline and other refined fuel.The Colonial Pipeline closure should serve as a wake-up call to pipeline protesters who pretend we dont need the energy transported by these pieces of critical infrastructure, opined the Center of the American Experiment, a Minnesota-based conservative think tank. We are as reliant upon oil and natural gas as we are water, and that reality isnt going to change anytime soon.Refining advocates also used the fuel shortages to highlight the decline in fuel-making capacity in the Northeast. Where the East Coast previously had 12 refineries, closures have dropped that number to four. By some estimates, the Atlantic Basin has lost a total of 1.5 million barrels per day of refining capacity since 2008, making the region more reliant on imports and fuel transported by Colonial.A New Jersey lawmaker pressed administration officials to address the decline during a briefing Wednesday. Each time a refinery closes, were losing the ability to fuel our defense, the unidentified lawmaker said, according to a person on the call.The coal industry, whose chief product is a rock that cant be carried by pipelines, used the incident to highlight the value of its fossil fuel. The National Mining Association, which represents companies such as Consol Energy Inc. and Peabody Energy Corp., promoted coal as a valuable insurance policy in an era of emerging and deceptively dangerous threats.Its becoming clear that pipelines and just-in-time fuel delivery are a particularly vulnerable link in the equation, the Washington-based trade group said in a statement Wednesday. The months of fuel stored on site at coal and nuclear power plants add a layer of security and resilience we have long taken for granted and continue to undervalue.Biden administration officials cited the crisis to highlight the presidents multi-trillion-dollar plans for investing in the nations highways, electric vehicle charging and the grid.This incident also reminds us that infrastructure is a national security issue, and the reality is that investing in world-class, modern and resilient infrastructure has always been central to ensuring our countrys economic security, our national security and, as were seeing right now, that includes cybersecurity, Transportation Secretary Pete Buttigieg said at a White House briefing.Energy Secretary Jennifer Granholm noted at least one group hasnt been affected by the pipeline outage and the fuel shortages it caused along the East Coast.If you drive an electric car this would not be affecting you, clearly, she said during a White House briefing Tuesday.For more articles like this, please visit us at bloomberg.comSubscribe now to stay ahead with the most trusted business news source.2021 Bloomberg L.P.
Scientists have started to test whether natural killer, or NK, cells can be trained to go after hard-to-cure blood cancers in human patients. But making these sentinels of the innate immune system a potential boon to human health spans might be simpler: Rather than needing to be genetically engineered or primed with synthetic antibodies, they just need to be turned on.
In mice, researchers reported on Monday in the journal Med, activating NKT cells can eliminate the senescent cells partly responsible for many diseases of aging. If the results hold up, they could offer a promising alternative to senolytics experimental drugs that destroy these zombified cells that pile up and pollute your tissues as you get older. Although dozens of such drugs have postponed or even reversed diseases of aging in mouse experiments, clinical trials have thus far underwhelmed.
Its an interesting approach that works in experimental animals with two different conditions, said geriatrician James Kirkland of the Mayo Clinic, whose discovery that giving old mice senescent cell-crushing compounds makes the animals live longer, healthier lives, helped take senolytics from backwater to boomtown. Were going to need multiple ways of getting at senescent cells, he said. Any step forward is important, and this is quite a nice step forward. But he cautioned that a single senolytic strategy is unlikely to work for all age-related conditions.
For decades, scientists had largely ignored senescent cells old and arrested in a permanent state of suspended animation dismissing them as a quirk of evolution, a clever way for the body to keep damaged cells from proliferating into cancer. But more recently, Kirkland and other researchers established that senescence is actually a driver of the decrepitude that comes with old age. As cells stop dividing, they dont exactly go dormant. In their zombie-like state, they start spewing a cocktail of toxic molecules that cause inflammation, damage surrounding tissues, and contribute to diseases like osteoarthritis, atherosclerosis, diabetes, and Alzheimers.
That realization spurred the creation of at least two dozen companies developing ways to systematically purge the body of senescent cells. Senolytics attracted this wave of investment because it promises a scintillating and fundamental shift in medicine away from the one-drug-one-target-one-disease paradigm of the last century, toward correcting a root cause behind many of them with a single treatment.
One of those researchers is the new studys senior author, Anil Bhushan of the University of California, San Francisco. In 2019, his lab traced the progression of type 1 diabetes in mice and human pancreatic cells. They discovered that signatures of senescence preceded the onset of disease. When his team removed the senescent pancreatic cells in mice, their metabolism stabilized and their diabetes symptoms went away.
What Bhushan took away from that study was that senescence didnt just happen when the bodys biological clocks wound down too far. It occurred in acute diseases too. Thered been talk in the field that an immune surveillance system maintained tissue homeostasis, said Bhushan. We postulated that that system was failing in the disease state and gradually failing in aging, so the only time wed see senescent cells is when this system fails.
To test that hypothesis, his team first went looking for clues as to the identity of their indolent immune cells. By comparing the transcriptional profile which genes were turned on and off in senescent pancreatic cells to healthy ones, they uncovered that the senescent ones boosted production of their antigen-presenting machinery. These are the proteins that, if a cell were infected with a pathogen, would shuttle little bits of the bacteria or virus to its surface, displaying them for immune cells to find. Then they cross-referenced those results with an analysis of senescent stem cells that accumulate in the fat tissues of obese mice who are fed a chronic, high-fat diet. Those cells also upregulated antigen-presenting molecules, and one in particular: CD1d. That was the lock, said Bhushan. And once wed found it, the key was then obvious.
Only one kind of immune cell binds to CD1d invariant natural killer T cells, or iNKTs. Comprising less than 1% of all peripheral blood immune cells, iNKTs are rare but critical components of the bodys surveillance system, scanning for infected and defective cells in need of removal. When they find them, iNKTs expel torrents of cytokines, which signal to other immune cells to do the dirty work. Bhushan figured that something was interfering with that process. And though he wasnt sure what it was, he knew there was a way to fix it.
In the early 1990s, Japanese scientists from Kirin Brewerys pharmaceutical research lab, looking for anticancer treatments in the porous bodies of marine sponges collected in the Okinawan sea, purified a lipid compound called -galactosylceramide. And they discovered that when CD1d grabs onto this -GalCer lipid, it turns on iNKTs like crazy in mice.
So Bhushans team shot up some of their diet-induced obese mice with -GalCer. Within days, the levels of senescent cells in the mouse fat tissues had dropped. So did their fasting glucose. Their insulin sensitivity also improved. Their metabolism started to look normal.
To see how generalizable the effect was, they repeated the experiment with mice whose lung tissues had been damaged by a chemotherapy drug a common model for idiopathic pulmonary fibrosis, a serious and incurable human lung disease, and one of the nastier complications of Covid-19. In those mice, -GalCer successfully activated iNKTs, again resulting in the removal of senescent cells. The treated mice had fewer damaged cells, and they also lived longer than the control group.
Finally, Bhushan and his colleagues looked at how well activated iNKT cells could tell senescent human cells from healthy ones when cultured together. After 18 hours, 100% of the senescent cells had been destroyed; the vast majority of healthy cells went unscathed. That could give the iNKT approach a potential advantage over the senolytics drugs already in development.
Most of them are repackaged cancer drugs that work by flipping on senescent cells self-destruct buttons. But because zombie cells share a lot of molecular features with their fully animated counterparts, those drugs run the risk of creating lots of collateral damage. Clinical trials of one such drug, 17-DMAG, were abandoned due to toxic side effects in the kidney and brain. Other groups are trying to solve this by engineering a different kind of immune cell, the CAR-T cell, to become a better anti-aging treatment. But CAR-Ts come with their own dangerous side effects and are expensive to make.
Bhushan is optimistic that by returning the cells best trained to suss out senescent cells to the ranks of active immune duty, both these safety and cost concerns can be ameliorated. We have this built in specificity of the immune cells part of their job is telling senescent cells apart from healthy ones were just helping them do their job, he said.
Its still an open question. But clinical trials to answer it could be underway by the end of next year. Bhushans initial discoveries are now being developed by a biotech startup called Deciduous Therapeutics, which he co-founded in 2018. Deciduous is backed by 8VC, CRV, and Laura Demings Longevity Fund, and has until now, been operating in stealth. CEO and co-founder Robin Mansukhani told STAT that the company has been focusing on developing compounds that can best stimulate human iNKTs, whose receptors are structurally a bit different from those of a mouse. He expects Deciduous to file its first investigational new drug application to start human testing within the next 18 months, likely for a metabolic disease or fibrotic lung disorder.
Investors pumped the brakes on senolytics after one of the biggest and brightest stars of the nascent sector and another Longevity Fund portfolio company, Unity Biotechnology, announced last August that its lead drug candidate had failed to reduce knee pain in patients with osteoarthritis. The experimental drug was immediately and unceremoniously dumped, along with nearly one-third of Unitys staff.
But despite the recent slowdown, Mansukhani remains optimistic. The issue in the field has always been what is the actual immune system process behind senescence clearing?he said. And I feel like weve uncovered that.
Mayos Kirkland cautions that deciphering one chapter of the immune system users manual isnt likely to be the whole story. Senescence can be caused by lots of things aging, yes, but also obesity, chemotherapy drugs, and radiation. There are about 40 to 50 different things that can push a cell into a death spiral, said Kirkland. That makes it really hard to define what a senescent cell is, because its molecular makeup depends on how its senescence was induced.
But the good news, according to Kirkland, is that all the fundamental aging processes mitochondria powering down, oxygen radicals disfiguring DNA, rampant inflammation, the spiral toward senescence appear to be tightly interlinked. Its looking increasingly like if you hit one part of this network of things going on, you affect all the rest, and usually in a positive way, he said.
Kirkland, together with his team at Mayo, have had some success with a cocktail of dasatinib and quercetin. In 2019, they reported positive results from a Phase 1 pilot study of nine diabetic kidney disease patients senescent cells were reduced. A Phase 2 study is now underway. And his team has several more trials for serious conditions, including osteoporosis and Alzheimers disease, in the pipeline. Kirkland serves as a scientific adviser to a new senolytics company called NRTK Biosciences that has yet to receive funding and anti-aging supplement company Elysium Health.
But the real question for the future, said Kirkland, is which interventions can you combine to get an additive, synergistic effect? Something that actually alleviates not just one disease of aging, but many, or even all of them? Figuring out how immune cells interplay with senescence is going to be the start of looking for those combinations.
Thats whats next for Bhushans lab a painstaking process of deleting different antigen-displaying peptides across dozens of types of immune cells, and mapping out the almost infinitely complex network of interactions brewing in the toxic stew surrounding senescent cells.
We know we only have part of the story, Bhushan said. We know we can fix whatever is going wrong with iNKTs, but we still dont know exactly what that is.
iS CLINICAL Active Serum
For our 26th annual Best Beauty Buys, the InStyle team worked with leading dermatologists, makeup artists, hairstylists, wellness experts, fragrance connoisseurs, and manicurists to find out which products they can't get enough of. Now, the votes are in and you'll want to get ahold of these 229 beauty game-changers.
Peek through any celebrities medicine cabinet, and a few brands tend to surface time and again. There are famous aesthetician favorites like Skinceuticals, liquid luxuries like Augustinus Bader, clean beauty face oils like True Botanicals and Vintners Daughter, and the big kahuna in a little blue bottle: iS Clinical Active Serum.
It might look unassuming, but the results iS Clinical delivers has made fans out of Jessica Alba, Rosie Huntington-Whiteley, Chrissy Teigen, January Jones and countless beauty editors whove worked their way through all the skincare one face can handle. No matter what, the anti-aging, acne- and dullness-fighting serum clears up stubborn problems and converts hyperpigmentation, redness, and wrinkles into glowing, red carpet-ready skin.
They clearly used magic to make this, one shopper writes, and another seconds that the stuff is no joke. I mean, wow. I bought this on a whim thinking it would just be another one of those overpriced products that does nothing, but my skin has improved drastically in the past two weeks since I started using it, the latter person continues. I struggled with cystic acne, scarring, texture, dullness, etc. My acne is pretty much gone, my scarring has decreased significantly, and my tone just looks more even all over.
iS Clinical Active Serum
Shop now: $138; dermstore.com
The Active Serum formula is so intensely loved that its won 58 pages of glowing reviews on Dermstore, and board-certified dermatologist Diane Madfes confirms that its worth its weight in gold. This is an all-around fabulous product, great for treating acne and preventing wrinkles, Madfes tells InStyle. The ingredients are key, as iS CLINICALs Active Serum is water-based with glycerin to moisturize. The polyporus umbellatus mushroom is a lightener and an antioxidant, while salicylic acid is an exfoliant.
Madfes explains that the formulas efficiency sets it apart, since the serum works quickly to fade post-acne marks and improve your skin texture, and shoppers also see tighter pores and super smooth, dewy skin. This serum is the best exfoliating serum I've used so far, and I've used a lot as I am a licensed aesthetician, another expert says. Really great for clogged pores and acne! Others dub it the best serum on the market and a miracle worker, its firming abilities and scar-erasing transformations enough to earn it a lifetime spot in their skin routines.
Even healthcare workers spending days on end in their masks say its life-changing, and former spa employees say that after seeing it recommended to every client that came in, they tried it and watched their dark spots disappear within a week. With continued use, multiple people say they finally feel un-self conscious enough to go without makeup over their hyperpigmentation and melasma.
Acne is the worst, and I have been fighting it ever since I hit puberty, another reviewer recounts. I have tried thousands of products, saying, Oh, maybe this one will work. Close to giving up, they ordered the iS Clinical Active Serum. I saw results within days. My acne actually started to go away and whats more, it actually prevents breakouts. Im in love with this product and I will be using it for the rest of my life, or until my acne decides to go away.
Its effect on wrinkles is no less impressive: After a few weeks of use, it toned down fine lines so completely that a shopper was shocked when they reappeared after running out of the serum. Repeated themes? The Active Serum is unbeatable, and worth every penny. Try it for yourself, and watch your skin shape up before your eyes.
Relying on takeout for many of your meals is one habit that can age you.
Image Credit: Westend61/Westend61/GettyImages
As hot as the anti-aging market is right now, we all know that aging is inevitable. And yet, it's entirely possible to do it well.
When it comes to aging, the goal isn't necessarily just to live longer, but to extend your years of healthy life.
"The scientific term is 'healthspan,' which represents the time period of life in which a person is free of debilitating disease," Stephen Anton, PhD, of the Institute on Aging in the Department of Aging & Geriatric Research at University of Florida Health, tells LIVESTRONG.com. This is a mix of health, happiness and good quality of life.
While there is a genetic component to aging, how you live matters, too.
"It's pretty clear that there are certain habits that can shorten our lifespan," Dr. Anton says. We can then presume that avoiding these habits may help you may live longer and better.
Here are six things that age you:
Mistake 1: Sitting Around a Lot
Being sedentary is a risk factor for a host of diseases. But in the past, there was the thought that if you exercised during the day, it didn't matter if you were parked on your duff for the rest of it.
"It's becoming clear that this is not the case. Even if you do exercise, what you do in the remaining 16 hours when awake also has an influence on your health," Dr. Anton says.
Fix it: Breaking up periods of sitting with activity is a good idea, so stand up or walk around for a few minutes each hour, he says.
Conversely then, the most important factor in aging well is exercise, Carolyn Kaloostian, MD, MPH, geriatric medicine specialist with Keck Medicine of USC in Los Angeles, tells LIVESTRONG.com. A regular walking routine is what you need. "This helps maintain resiliency. Resiliency is what keeps us from aging," she says.
Mistake 2: Dining Out Too Much
We Americans generally eat too much sodium (3,400 mg per day, on average, when the recommended limit is 2,300 mg), and about a quarter of it comes from restaurant food, according to the Centers for Disease Control and Prevention (CDC).
Fix it: "Reducing sodium content in meals is key. This is particularly true for preventing chronic diseases like hypertension and heart disease," Dr. Kaloostian says.
She recommends making more of your meals at home to avoid the hidden sodium that's packed into restaurant and take-out fare.
Mistake 3: Skimping on Vegetables
Veggies might not be the sexiest thing and you've heard it time and time again to eat more but skipping them does a disservice to your health.
"The foundation of your health is the food [you eat]," Kimberly Gomer, RD, LDN, director of nutrition at Pritikin Longevity Center + Spa in Miami, tells LIVESTRONG.com. "I've been at Pritikin for nine years. After changing people's diets, the first thing that happens is that they look like the fountain of youth," she says.
Fix it: Plant-based diets rich in veggies provide ample fiber a heart-healthy, insulin-regulating, anti-cancer nutrient and protective anti-inflammatory vitamins, minerals and phytonutrients. And if you're filling up on veggies, you're also not eating the types of processed foods high in sugar, salt and fat that drive disease-causing inflammation.
Mistake 4: Staying Up Late and Eating Late
"Sleep restores the mind and body by allowing cells to repair and rejuvenate," Dr. Anton says. "It is vital for health on par with a healthy diet and physical activity. These are the big three for aging," he says.
Fix it: In truth, everyone needs a different amount of sleep, but the general recommendation is to get at least seven hours of shut-eye each night. The key is that you should wake up feeling rested.
Not everyone has the luxury of choosing the hours they work, but if you have control of your schedule, you'll also want to sleep when it's dark and wake up when it's light, a pattern that's health-promoting, Dr. Anton says. (Yes, this sounds basic, but we all know that a solid sleep routine doesn't always happen in practice.)
Lastly, avoid eating high-calorie, high-fat and high-sugar foods or drinking a lot of alcohol too close to bedtime.
"Those behaviors disrupt sleep and impair the body's ability to go through important cellular quality control processes," Dr. Anton says. That process is when cells remove waste in the form of toxins or damaged cells so that they can repair and rejuvenate to function in a healthier manner.
Allow at least a couple hours between eating and going to sleep, he says.
Mistake 5: Drinking a Lot of Alcohol
Overall, the pandemic hasn't been good for our drinking habits, and many people report increasing their alcohol consumption. But it's a good idea to scale back.
"Chronic, excessive alcohol consumption has significant impacts on aging well. It impacts nutrition with deficiencies in thiamine (vitamin B1) and other nutrients for brain and heart health," Dr. Kaloostian says.
What's more, excessive alcohol also bathes your liver and bone marrow in toxins that damage your organs and immune system, she says.
Fix it: While the current recommendation from the CDC is that people assigned male at birth should limit themselves to two drinks per day and people assigned female at birth should stick to no more than one, there's increasing evidence that there are health-protective benefits of consuming just half of that.
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5 Habits That Age You, According to Longevity Experts - Livestrong