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Category Archives: Anti-Aging Medicine

Ponce Therapeutics Inc. Commences First R & D Program in Anti-Aging Products for Skin – PRNewswire

MIAMI, Feb. 8, 2021 /PRNewswire/ -- Ponce Therapeutics, Inc. ("Ponce"), a company leveraging the growing scientific knowledge surrounding the aging process to develop anti-aging technologies, has now become operational with the launching of its first R & D program, targeting aging-associated skin disorders. The Company has secured laboratory space in Houston, TX, and has hired its first scientists for executing their R & D plan targeting the elimination of p16-expressing cells in the skin. The cell proliferation inhibitor, p16, is highly expressed in both senescent cells and in in situ carcinoma (Bowen's Disease), which will be the focus of Ponce's efforts for first product approval.

Rapha Capital Management, LLC (https://www.raphacap.com), an investment management firm located in Miami, Florida, through Rapha Capital Investment XIII, LLC ("RCI XIII") (an entity managed by Rapha Capital), led Ponce's recently closed Convertible Note financing. The $1,500,000 financing will be used to transition Ponce into an operational company and begin execution of Ponce's R & D plan. With the close of the Convertible Note financing, Kevin Slawin, founder and President of Rapha Capital Management, added the title of Executive Chairman, to his CEO role at Ponce.

Rapha Capital is an investment management firm focused on making strategic investments in early stage, non-public biotechnology companies, through special purpose joint venture entities which it manages. Rapha Capital was founded by its President, Kevin Slawin, M.D., a successful and experienced oncologic and robotic surgeon. After leaving practice, Dr. Slawin has been serving as a biotech consultant, investor, and founder, focusing on disruptive technologies in oncology, T cells and immunotherapy, and other breakthrough healthcare technologies. He is the founder of Bellicum Pharmaceuticals, Inc.("Bellicum"), a publicly traded company listed on NASDAQ, leading Bellicum to a successful $161 million IPO in December, 2014. He also plays a guiding role in several of the investments managed by Rapha Capital in certain companies, serving as a board member at 3DBio Therapeutics, Inc. (https://3dbiocorp.com/), FIZE Medical, Inc. (www.fizemedical.com), and Demeetra AgBio, Inc. (www.demeetra.com).

Kevin Slawin, MD is the founder of Ponce, and will serve as the Chairman and CEO. David Spencer, PhD. is the founding Chief Technology Officer. Ponce Therapeutics, Inc. reunites the team that founded Bellicum Pharmaceuticals and took it public in 2014 with a $55 million crossover Series C and a $161 million IPO. The team is retooling their original cell control technology with state-of-the-art advances towards their new goal of creating anti-aging products with a solid underlying scientific basis that actually work.

"The science of aging has continued to mature and can now provide a scientific basis for technologies to reverse the aging process in humans. Proof of concept data in animal models demonstrates that removal of senescent cells from organs improves their function and imbues them with a more youthful profile. Targeting p16-expressing cells for apoptotic elimination is one approach to removing senescent cells from the body and is also a valid approach to targeting Bowen's disease of the skin, which also expresses high levels of p16, profile," said Dr. Slawin. "I'm excited to begin work in the anti-aging space, which I believe will quickly rival oncology in both value and interest" he added. "Given our greater than two-decade animal model and clinical experience with regulated cell signaling and cell survival, along with recent advances in non-viral gene delivery platforms, we are now poised to leverage an increasingly detailed, mechanistic understanding of aging to arrest or even reverse it," added Dr. Spencer.

About Rapha Capital Management, LLC Rapha Capital Management, LLC is an investment management firm located in Miami, Florida, focusing on strategic investments in early stage, non-public biotechnology companies. Rapha Capital was founded by its President, Kevin Slawin, MD, a successful and experienced oncologic and robotic surgeon, biotech consultant, investor, and founder focusing on technologies in oncology, T cells and immunotherapy, as well as other breakthrough healthcare technologies. He is the founder of Bellicum Pharmaceuticals, Inc. (NASDAQ: BLCM). He is co-Inventor of the FDA,-approved "prostate health index (phi)" test licensed and marketed by Beckman Coulter and utilized around the world. He has published extensively in top medical and scientific journals including theJournal of the American Medical Association (JAMA), Journal of the National Cancer Institute (JNCI), and the New England Journal of Medicine (NEJM). He has also been routinely listed in America's Top Doctors for Cancer (Castle Connolly Medical) and The Best Doctors in America (Woodward/White). In 2003, he was awarded the F. Brantley Scott, Jr., Award for Innovation and Creativity in Urology.

About Ponce Therapeutics, Inc.Ponce Therapeutics "Anti-aging Technologies Based on Real Science and Developed by Real Scientists" - Ponce Therapeutics is leveraging the growing scientific knowledge surrounding the process of aging to develop its first state-of-the-art biotechnology platform to restore the youthful balance of aged or "senescent" and young cells in the skin, targeting the p16-expressing senescent cells for elimination. This provides a "reboot" of one's genetic program to turn the clock on one's skin back to its youthful exuberance. Targeting p16 will also potentially allow targeting of Bowen's disease as the regulatory pathway for approval. While initially focused on skin, Ponce is planning to develop a wide-ranging portfolio of anti-aging products based on the best science in the nascent anti-aging field. Ponceis headquartered in Miami, Florida with research facilities located in Houston, TX. For more information, visitwww.poncethera.comor email [emailprotected].

For more information about Ponce Therapeutics, Inc., email [emailprotected] or visit https://www.poncethera.com

For more information about Rapha Capital Management, email [emailprotected]or visit https://www.raphacap.com

SOURCE Rapha Capital Management, LLC and Ponce Therapeutics, Inc.

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Global Medical Aesthetics Market Insights, Size Estimation, Research Insights, COVID-19 Impact and Future Trends By 2028 KSU | The Sentinel Newspaper…

Global Medical Aesthetics Market Report Provides Future Development Possibilities By Key Players, Key Drivers, Competitive Analysis, Scope, And Key Challenges Analysis. The Reports Conjointly Elaborate The Expansion Rate Of The Industry Supported The Highest CAGR And Global Analysis. This Report Providing An In Depth And Top To Bottom Analysis By Market Size, Growth Forecast By Applications, Sales, Size, Types And Competitors For The Creating Segment And The Developing Section Among The Global Medical Aesthetics Market. Market Expansion Worldwide With Top Players Future Business Scope and Investment Analysis Report

Global Medical Aesthetics Market Research Report Will Help To Take Informed Decisions, Understand Opportunities, Plan Effective Business Strategies, Plan New Projects, Analyze Drivers And Restraints And Give Vision On The Forecast. Report Is A Specialist And Broad Research Report On The Major Regional Market Conditions, Concentrating On The United States, China, Europe, Japan, Southeast Asia, And India Regions.

Global Medical Aesthetics Market By Product type (Aesthetic Lasers, Energy Devices, Body Contouring Devices, Facial Aesthetic Devices, Aesthetic Implants, Skin Aesthetic Devices), Application (Anti-Aging and Wrinkles, Facial and Skin Rejuvenation, Breast Enhancement, Body Shaping and Cellulite, Tattoo Removal, Vascular Lesions, Psoriasis and Vitiligo, Others), End User (Cosmetic Centres, Dermatology Clinics, Hospitals, Medical Spas and Beauty Centres), Distribution Channel (Direct Tender, Retail), Geography (North America, South America, Europe, Asia-Pacific, Middle East and Africa) Industry Trends and Forecast to 2026

Global medical aesthetics market is projected to register a healthy CAGR of 12.1% in the forecast period of 2019 to 2026.

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Competitive Analysis: Global Medical Aesthetics Market

Some of the major players operating in the global medical aesthetics market are Allergan, Bausch Health Companies Inc., Lumenis, Shanghai Fosun Pharmaceutical Group Co. Ltd., Cynosure, Syneron Medical Ltd, Aerolase Corp., A.R.C. Laser Gmbh, Asclepion Laser Technologies Gmbh, Btl, Cutera, Eclipse, Lutronic, Mentor Worldwide Llc, Merz Pharma, Quanta System, Sciton Inc., Sharplight Technologies Inc, Syneron Medical Ltd., Venus Concept.

Aesthetics devices are an innovative advancement, providing a solution to patients which deal with the ingenuity of creating beauty. The medical aesthetics devices is a growing market owing to its benefits such as maintaining the youthful appearance, pain free and non-invasive beauty treatments, maintenance free skin that remains smooth and hairless without the need for shaving, waxing or unpleasant hair treatments, improving the cosmetic appearance, and technological advancement in medical aesthetics devices.

The market is showing a substantial growth in the emerging countries as these countries are adapting to the trends of urbanization. Brazil, South Africa, Thailand and many others have improved in the past one decade. People are opting different aesthetics surgeries to maintain themselves, which give them better results without any stressful physical efforts. Medical Aesthetics is one of the most trending concepts of the 21stCentury which will show a substantial increase in the future as there is a great technological advancement and innovation in the field by the companies dealing with these devices making them safer and even less invasive leading to more population opting for these procedures.

Segmentation: Global Medical Aesthetics Market

Global medical aesthetics market is segmented into 4 notable segments such as product type, type of care, accessories and end user

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Product Launch:

Allergan

The company was founded in 2013 and headquartered at Dublin, Ireland. The company is focused on developing, manufacturing and commercializing branded device, biologic, pharmaceutical, surgical and regenerative medicine products for patients throughout the world. The main business segments are US Specialized Therapeutics, US General Medicine, International. The revenue of the company in healthcare sector 2018 was USD 16,550.8 Million. The company has global presence in North America, Asia Pacific, South America, Europe and Middle East & Africa.

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Bausch Health Companies Inc.

The company was founded in 1959 and headquartered at Quebec, Canada. The company is engaged in manufacturing and marketing a broad range of branded and generic pharmaceuticals, over-the-counter (OTC) products and medical devices. The main business segments are Bausch + Lomb/International, Branded Rx, U.S. Diversified Products. The revenue of the company in healthcare sector 2018 was USD 8,174.8 Million. The company has global presence in North America, Europe, the Middle East, Africa, Asia Pacific and Latin America.

Luimenis

The company was founded in 1991; headquarter in Yokeneam, Israel. The company is engaged in the field of minimally-invasive clinical solutions for the Surgical, Ophthalmology and Aesthetic markets, and expert in developing and commercializing innovative energy-based technologies, including Laser, Intense Pulsed Light (IPL) and Radio-Frequency (RF). The company has global presence in North America, South America, Europe, Asia, Africa and Australia.

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Global Medical Aesthetics Market Insights, Size Estimation, Research Insights, COVID-19 Impact and Future Trends By 2028 KSU | The Sentinel Newspaper...

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Writing is the best medicine – The London Economic

In addition to carving out a distinguished medical career, Dr Cliff Bacchus has built a reputation as a novelist unafraid to tackle challenging social issues, most recently the practice of intermarriage between cousins.

By the time they reach their sixties, most people would be looking forward to retiring and taking things easier. For medical doctor Dr Cliff Bacchus, however, it marked the launch of a second career as a novelist.

Now aged 78, Dr Bacchus has published three critically-acclaimed novels within the last 15 years, with the latest gripping psychological thriller Curses of Cousins just released.

For the Bahamas-based author, who also runs two busy pain management clinics in the country, writing is a much-needed creative escape from the pressures of the day job.

Since 1974, he has served the medical needs of the Bahamian island that has been his adopted home since he left his native Guyana to study medicine in what was then Communist Russia.

During all that time, he has consulted the rich, the famous, and the less fortunate with equal attention, and care for all, initially as a senior medial officer working for the government before going into private practice in the early 2000s.

His standing as a physician also led him to be cast as a doctor in 2007 Bahamas-set Hollywood film Bad Girl Island after he conducted the medical examinations for the director, Stewart Raffill, and crew.

Perhaps somewhat unsurprisingly, Dr Bacchus draws heavily upon his training and experiences for his novels also including his literary debut, 2007s A Doctor and a Gentleman and 2011s Do No Harm in the sense that they are all fundamentally driven forward by a thought-provoking consideration of contemporary medical issues or ethics.

In the case of Curses of Cousins, the narrative is wrapped around an exploration of intermarriage between cousins.

It is a practice that goes on not only in certain communities within the Bahamas but around the world, including the UK. While perfectly legal, it is a semi-taboo subject within society, hardly spoken of.

The problem is that this practice also carries with it a serious risk of genetic defects in any resulting offspring. Indeed, it is believed that two children born from such unions die in the UK from resultant genetic abnormalities every single week.

In the novel, the protagonist, teacher Brooklyn Watts, sets out to find out why her family, and many other families on the fictional Bahamian island of Sigatoo, suffer chronic, incurable illnesses.

In her case, it is alopecia and multiple sclerosis (MS), and, as she quickly comes to learn, her and others ill-health, previously attributed to a curse, is in fact a direct result of the traditional island practice of cousin marriage.

Despite the pain she suffers daily from her debilitating condition, she sets out on a quest to educate the population about the risks that such marriages carry to the next generation.

For Dr Bacchus, who was named Physician of the Year by the Government of the Bahamas in 2000, it is a vitally-important health issue to address.

I got the idea for Curses of Cousins as I have had several patients with genetic-based conditions that resulted from intermarriage between cousins, he says.

Im not calling for the practice to be banned outright, but there needs to be an open acknowledgment that children of such marriages run a significant risk of inheriting genetic defects that could impact their quality of life.

With this awareness then, at least, those who still wish to enter into such relationships can understand the importance of carrying out genetic counselling and blood tests to ensure a healthy progeny.

The novel is also notable for another battle that Brooklyn must face while trying to confront ignorance, superstition, and traditionalism within her society: a war between the literal forces of good and evil for control of her mind.

I always include a metaphysical aspect to my novels, explains Dr Bacchus who, in additional to a medical degree and membership of the American Association of Family Physicians and the American Association of Anti-Aging Medicine, holds a degree in metaphysical science and is the Worshipful Master of his islands Masonic lodge.

I do believe that beyond the physical we are all attuned to a higher, cosmic consciousness.

In Curses of Cousins this war between the personifications of good and evil adds a deeper level to the readers understanding of Brooklyn, and also another perspective on the obstacles she must overcome from certain parts of society in bringing about positive change.

As well as praising his latest novel for its originality and daring to broach the pressing issue of cousin marriage, reviewers have also highlighted Dr Bacchuss realistic depiction of a female lead a rare achievement for a male author.

This, however, is something that he attributes as much to his environment as his writing skills.

He says: All my life Ive been in the company of women. My children were all girls and in all my years of practice I have worked alongside female nurses.

Its given me a better understanding of the female mind than most men, I think, and it is wonderful that readers and reviewers concur.

Brooklyn was a fascinating character to create, being independently-minded, courageous and determined to protect future generations so that they wouldnt suffer in the same way that she does.

Some readers have called her inspirational, and that makes the whole writing process more than worthwhile.

I always intended to highlight the issue of intermarriage through fiction because it stands a much better chance of reaching the widest audience, compared to a dusty old academic paper that will never be read by anyone save other doctors.

But a novel stands or falls on whether the central character engages with readers, so it looks like all those years in almost exclusively female company has paid off.

As to the future, Dr Bacchus is already working on his next novel, which will be focused on another global issue world poverty.

Writing keeps my young, he adds. Its far more relaxing the medicine while also providing the opportunity to communicate with the world.

Curses of Cousins by Cliff Bacchus is out now on Amazon , priced 9.07 in paperback and 3.02 as an eBook.

EXCLUSIVE INTERVIEW WITH DR CLIFF BACCHUS

Dr Cliff Bacchus discusses his new novel, psychological thriller Curses of Cousins, and what motivates him as an author.

Q. What was your motivation for becoming an author?

A. To expand my outreach to people around the world.

Q. Your latest novel deals with a very grave subject: the risk of genetic abnormalities from intermarriage. Why did you feel it better to cover this subject through fiction than nonfiction?

A. Through fiction, I can reach more people, and generate more interest through theme, plot structure, unique characterisation, and suspense.

Q. What do you hope readers get from reading your new novel, Curses of Cousins?

A. I want them to grasp the theme: that cousins marrying cousins may not be the best for the children you give birth to. However, this is not a concrete rule. There are many who intermarry because of custom and religion, but it is time to reflect on the subject. If it works for you, fine! It is my point of view, based on experience as a medical doctor for nearly five decades.

Q. How did you get the idea for your latest novel?

A. From my medical experience over many decades.

Q. Describe a typical day in your life

A. I rise early, write for two hours until clinic time, 8 am to 11 am. Then its clinic again from 3 pm to 5 pm, followed by a walk and watching BBC news, CNN and talk shows, or a spot of painting on canvas. Bedtime is by 12 midnight.

Who are your literary inspirations, and why?

A. Shakespeare, Jane Austin, and Sidney Sheldon. Inspirational!

Q. All your novels include a metaphysical element. Can you explain why you feel it important to weave this into your stories?

A. Metaphysics deals with abstract concepts such as being, knowing, identity, time, and space. My novels are just about that. My novels must have meaning!

Q. If you could offer one piece of advice to somebody wanting to become an author, what would it be?

A. Be prepare to work hard and love it. Be prepared to accept the lonely life and love it. Be prepared to do research and love it.

Q. What satisfaction does writing bring you?

A. Knowing that I can communicate the truth and hope for the acceptance of it.

What can readers expect next from you?

A. Another work of fiction as I hone the craft for better and better.

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Writing is the best medicine - The London Economic

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The Role of Hormones in Immunocompetence – Anti Aging News

The growing importance of hormonal health is becoming an integral component of modern medicine especially as the focus shifts toward maintaining and boosting immunocompetence in the population. Many plausible benefits of hormonal factors on autoimmunity have received growing attention in recent years from the scientific community. Research has been conducted investigating the relationship between immune system function and sex hormones testosterone and estrogen.

Importantly, the immune systems of men and women are known to function differently with 80% of autoimmune diseases occurring in women who tend to show stronger immune responses than their male counterparts. Stronger immune responses in women produce faster pathogen clearance and improved vaccine responsiveness while also contributing to their increased susceptibility to inflammatory and autoimmune diseases.

Results from previous experimental studies have revealed that testosterone can have a medium-sized immunosuppressive effect on immune function, however, the impact of estrogen can vary depending on the immune marker measured. Such differences in immune function and responses have contributed to health- and life-span disparities between sexes yet the role of hormones in immune system aging remains to be understood.

Immune Differences and Dimorphism

The differences in immunocompetency between male and female patients are associated with varying testosterone and estrogen levels major regulators of the immune system. Differences in gene expression between the sexes contribute to the concept of immune dimorphism though they are limited to one or a few types of immune cells. Furthermore, genomic differences between sexes have been found to become more prominent after the age of 65 with men having a higher innate and pro-inflammatory activity along with lower adaptive activity.

Female and males have different energy and nutrient requirements largely based on interactions between external factors and sex hormones; interactions between hormones and a patients environment, including cigarette smoke and viral infections, can lead to variable responses in both genders. While enhanced immunity has been reported in female patients, making them less susceptible to viral infections, their hyper immune response can predispose them to immune-pathogenic effects. In addition, sex hormones can control the immune response via circadian rhythms and their ability to regulate T-cell mediated inflammation.

Microbial Composition

Emerging evidence also indicates that sex hormones can impact the guts microbial composition and thus, impact immunocompetency. Studies have shown that diet-based effects on the microbiome are more prominent in men than in women implicating that dietary interventions may have an influence on sex-based immune responses.

The gut microbiota landscape can impact the systemic levels of testosterone, changing metabolic profiles which may heighten the risk for chronic disease including diabetes. However, current knowledge of the mechanism by which microbiome-derived sex steroids impact immunity remains limited.

Previous research has shown that hormonal contraceptives can increase bacterial species, highlighting sex-hormone-dependent differences and their effects on systemic immune responses. However, the gut microbial composition can be influenced by a variety of factors outside of hormonal levels, such as genetics and dietary habits.

The mechanism underlying sex hormone expression and immunocompetency continues to be investigated; this may result in the improvement of future designs for targeted therapeutics that mitigate sex hormone-inflammatory activity or autoimmune diseases. Clinicians interested in expanding their knowledge on the role of hormones in immune function and longevity are invited to attend the cutting-edge, interactive online Role of Hormones in Immunocompetency and Longevity workshop taking place on February 20, 2021.

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Blink! The Link between Aerobic Fitness and Cognition – Anti Aging News

Researchers from the University of Tsukuba find that spontaneous eye blink activity explains the link between physical activity and cognitive function

Although exercise is known to enhance cognitive function and improve mental health, the neurological mechanisms of this link are unknown. Now, researchers from Japan have found evidence of the missing link between aerobic fitness and cognitive function.

In a study published in Medicine & Science in Sports & Exercise, researchers from the University of Tsukuba revealed that spontaneous eye blink rate (sEBR), which reflects activity of the dopamine system, could be used to understand the connection between cognitive function and aerobic fitness.

The dopaminergic system is known to be involved in physical activity and exercise, and previous researchers have proposed that exercise-induced changes in cognitive function might be mediated by activity in the dopaminergic system. However, a marker of activity in this system was needed to test this hypothesis, something the researchers at the University of Tsukuba aimed to address.

"The dopaminergic system is associated with both executive function and motivated behavior, including physical activity," says first author of the study Ryuta Kuwamizu. "We used sEBR as a non-invasive measure of dopaminergic system function to test whether it could be the missing link between aerobic fitness and cognitive function."

To do this, the researchers asked healthy participants to undergo a measure of sEBR, a test of cognitive function, and an aerobic fitness test. They also measured brain activity during the cognitive task using functional near-infrared spectroscopy.

"As expected, we found significant correlations between aerobic fitness, cognitive function, and sEBR," explains Professor Hideaki Soya, senior author. "When we examined these relationships further, we found that the connection between higher aerobic fitness and enhanced cognitive function was mediated in part by dopaminergic regulation."

Furthermore, activity in the left dorsolateral prefrontal cortex (l-DLPFC) during the cognitive task was the same or lower in participants with higher sEBR compared with lower sEBR, even though those with higher sEBR appeared to have greater executive function, and thus higher neural efficiency.

"Although previous studies have indicated that aerobic fitness and cognitive function are correlated, this is the first to provide a neuromodulatory basis for this connection in humans. Our data indicate that dopamine has an essential role in linking aerobic fitness and cognition," says first author Kuwamizu.

Given that neural efficiency in the l-DLPFC is a known characteristic of the dopaminergic system that has been observed in individuals with higher fitness and executive function, it is possible that neural efficiency in this region partially mediates the association between aerobic fitness and executive function. Furthermore, physical inactivity may be related to dopaminergic dysfunction. This information provides new directions for research regarding how fitness affects the brain, which may lead to improved exercise regimens. For instance, exercise that specifically focuses on improving dopaminergic function may particularly boost motivation, mood, and mental function.

We revealed that spontaneous eye blink rate significantly mediated the association between higher aerobic fitness and greater cognitive function. indicates standardized regression coefficient, which represents the degree of association between variables.

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Blink! The Link between Aerobic Fitness and Cognition - Anti Aging News

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Ponce Therapeutics Inc. Commences First R & D Program in Anti-Aging Products for Skin – BioSpace

MIAMI, Feb. 8, 2021 /PRNewswire/ -- Ponce Therapeutics, Inc. ("Ponce"), a company leveraging the growing scientific knowledge surrounding the aging process to develop anti-aging technologies, has now become operational with the launching of its first R & D program, targeting aging-associated skin disorders. The Company has secured laboratory space in Houston, TX, and has hired its first scientists for executing their R & D plan targeting the elimination of p16-expressing cells in the skin. The cell proliferation inhibitor, p16, is highly expressed in both senescent cells and in in situ carcinoma (Bowen's Disease), which will be the focus of Ponce's efforts for first product approval.

Rapha Capital Management, LLC (https://www.raphacap.com), an investment management firm located in Miami, Florida, through Rapha Capital Investment XIII, LLC ("RCI XIII") (an entity managed by Rapha Capital), led Ponce's recently closed Convertible Note financing. The $1,500,000 financing will be used to transition Ponce into an operational company and begin execution of Ponce's R & D plan. With the close of the Convertible Note financing, Kevin Slawin, founder and President of Rapha Capital Management, added the title of Executive Chairman, to his CEO role at Ponce.

Rapha Capital is an investment management firm focused on making strategic investments in early stage, non-public biotechnology companies, through special purpose joint venture entities which it manages. Rapha Capital was founded by its President, Kevin Slawin, M.D., a successful and experienced oncologic and robotic surgeon. After leaving practice, Dr. Slawin has been serving as a biotech consultant, investor, and founder, focusing on disruptive technologies in oncology, T cells and immunotherapy, and other breakthrough healthcare technologies. He is the founder of Bellicum Pharmaceuticals, Inc.("Bellicum"), a publicly traded company listed on NASDAQ, leading Bellicum to a successful $161 million IPO in December, 2014. He also plays a guiding role in several of the investments managed by Rapha Capital in certain companies, serving as a board member at 3DBio Therapeutics, Inc. (https://3dbiocorp.com/), FIZE Medical, Inc. (www.fizemedical.com), and Demeetra AgBio, Inc. (www.demeetra.com).

Kevin Slawin, MD is the founder of Ponce, and will serve as the Chairman and CEO. David Spencer, PhD. is the founding Chief Technology Officer. Ponce Therapeutics, Inc. reunites the team that founded Bellicum Pharmaceuticals and took it public in 2014 with a $55 million crossover Series C and a $161 million IPO. The team is retooling their original cell control technology with state-of-the-art advances towards their new goal of creating anti-aging products with a solid underlying scientific basis that actually work.

"The science of aging has continued to mature and can now provide a scientific basis for technologies to reverse the aging process in humans. Proof of concept data in animal models demonstrates that removal of senescent cells from organs improves their function and imbues them with a more youthful profile. Targeting p16-expressing cells for apoptotic elimination is one approach to removing senescent cells from the body and is also a valid approach to targeting Bowen's disease of the skin, which also expresses high levels of p16, profile," said Dr. Slawin. "I'm excited to begin work in the anti-aging space, which I believe will quickly rival oncology in both value and interest" he added. "Given our greater than two-decade animal model and clinical experience with regulated cell signaling and cell survival, along with recent advances in non-viral gene delivery platforms, we are now poised to leverage an increasingly detailed, mechanistic understanding of aging to arrest or even reverse it," added Dr. Spencer.

About Rapha Capital Management, LLC Rapha Capital Management, LLC is an investment management firm located in Miami, Florida, focusing on strategic investments in early stage, non-public biotechnology companies. Rapha Capital was founded by its President, Kevin Slawin, MD, a successful and experienced oncologic and robotic surgeon, biotech consultant, investor, and founder focusing on technologies in oncology, T cells and immunotherapy, as well as other breakthrough healthcare technologies. He is the founder of Bellicum Pharmaceuticals, Inc. (NASDAQ: BLCM). He is co-Inventor of the FDA,-approved "prostate health index (phi)" test licensed and marketed by Beckman Coulter and utilized around the world. He has published extensively in top medical and scientific journals including theJournal of the American Medical Association (JAMA), Journal of the National Cancer Institute (JNCI), and the New England Journal of Medicine (NEJM). He has also been routinely listed in America's Top Doctors for Cancer (Castle Connolly Medical) and The Best Doctors in America (Woodward/White). In 2003, he was awarded the F. Brantley Scott, Jr., Award for Innovation and Creativity in Urology.

About Ponce Therapeutics, Inc.Ponce Therapeutics "Anti-aging Technologies Based on Real Science and Developed by Real Scientists" - Ponce Therapeutics is leveraging the growing scientific knowledge surrounding the process of aging to develop its first state-of-the-art biotechnology platform to restore the youthful balance of aged or "senescent" and young cells in the skin, targeting the p16-expressing senescent cells for elimination. This provides a "reboot" of one's genetic program to turn the clock on one's skin back to its youthful exuberance. Targeting p16 will also potentially allow targeting of Bowen's disease as the regulatory pathway for approval. While initially focused on skin, Ponce is planning to develop a wide-ranging portfolio of anti-aging products based on the best science in the nascent anti-aging field. Ponceis headquartered in Miami, Florida with research facilities located in Houston, TX. For more information, visitwww.poncethera.comor email info@poncethera.com.

For more information about Ponce Therapeutics, Inc., email info@poncethera.com or visit https://www.poncethera.com

For more information about Rapha Capital Management, email info@raphacapital.comor visit https://www.raphacap.com

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SOURCE Rapha Capital Management, LLC and Ponce Therapeutics, Inc.

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Ponce Therapeutics Inc. Commences First R & D Program in Anti-Aging Products for Skin - BioSpace

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