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Category Archives: Anti-Aging Medicine

Why Silicon Valley Execs Are Investing Billions to Stay Young – Robb Report

Entrepreneur Dave Aspreys end-of-life plans are quite simple, really, even if some of his ambitions sound laughably optimistic to most of us.I want to die at a time and by a method of my own choosing, and keep doing awesome things until that day, he tells me. I dont think its outrageous to believe Ill make it to 180 years old. And if I run out of energy, itll just be because I did too much cool shit for my own good.

Asprey is strolling across his lush property in British Columbia, holding up his phone and pointing out the specimens in this years garden as we chat over Zoom in the midst of the global pandemic. Hes protecting his skin from the sun with a goofy Outdoor Research hat and wearing a long string of beads that he says are each over a hundred years old, from cultures around the world.

Asprey, 48, is the founder of the Bulletproof wellness empire and a vocal champion of the movement to extend human life expectancy beyond 100 years. Hes made millions by experimenting on his own body and packaging his home-brewed discoveries into books, a podcast, consulting services and consumer products (you may have even tried his butter-laced coffee). Asprey, who was a web-security executive before he became the Bulletproof Executive, is just one of a cadre of tech elite who have begun directing their attentionand truckloads of moneytoward the problem of life extension. Jeff Bezos, Peter Thiel, Sergey Brin, Larry Ellisonname a Silicon Valley A-lister and he or she is likely funding longevity research, experimenting with anti-aging interventions or both. These are the masters of the universe who see no reason they cant take the tech industrys optimization obsession and apply it to the ultimate challenge: conquering death itself.

And their efforts appear to be paying off: Thanks to a recent explosion of advances in longevity medicine, Aspreys vision of living healthfully into his second century might not be so crazy. In fact, for people in middle age right now, a handful of therapies in clinical trials have the potential, for the first time in human history, to radically transform what old age looks like. If the life extensionists are right, a person whos 40 today might reasonably expect to still be downhill skiing, running a 10K or playing singles tennis at 100.

Dave AspreyDave Asprey

If you do anti-aging right, Asprey insists, youll have a level of resilience and energy to fight what comes your way. If you get Covid-19, youre less likely to become very sick. The idea is that at a cellular level, youre making yourself very hard to kill.

The most extreme of the controversial interventions Asprey has undergone involved having stem cells extracted from his own bone marrow and fat and then injected into hundreds of locations on his body. Into every joint, between every vertebra and into my cerebrospinal fluid, face and sex organs, he tells me cheerfully. For what I spent on that, I could have bought a really nicely appointed Tesla.

He trots up a flight of stairs to his home office, which sits above a million-dollar lab filled with health gadgets, such as a cryochamber, a hypoxic trainer and an AI-enabled stationary bike. For a wealthy person, investing in your body should be a major part of your Im rich strategy, he explains. Personally, I think you should be spending at least 2 to 3 percent of your net worth on health and longevity. Get a personal chef who can cook you the right food. Its not that hard.

It might be an exaggeration to say BioViva CEO Liz Parrish believes death is optional, but for her, Aspreys goal of living to 180 shows a distinct lack of ambition. If you can reach homeostasis in the body, Parrish says, where its regenerating itself just a little bit faster than its degrading, then what do you die of? An accident or natural disaster, probably. Theres no expiration date at 90 or 100 years old.

Tall, blond and fit, Parrish cuts a strikingly youthful figure at 49one that might convince you to order whatever shes having. But, like Asprey, she has received criticism from the longevity research community for becoming patient zero in her own experimental drug trial, aimed at halting aging at the cellular level. In 2015, Parrish underwent telomerase and follistatin gene therapies in Bogota, Colombia. The procedures involved receiving around a hundred injections of a cocktail of genes and a virus modified to deliver those new genes into her bodys cells. The objective was to prevent age-related muscle loss and lengthen her telomeres: the caps at the end of our chromosomes. Scientists have identified their unraveling as not only a marker of aging but also a potential cause of age-related decline.

Liz ParrishLiz Parrish

Parrish told the media about her clandestine experiment and has published periodic updates on her condition in the five years since, and she reports that she has indeed increased her muscle mass and lengthened her telomeres. Parrishs punk-rock approach stems from her conviction that the medical-research communityboth the Food and Drug Administration (FDA) and researchers who arent business-mindedis moving too slowly, with too much red tape, when it comes to advancing aging therapeutics. But gene therapy is a relatively new area of medicine that brings with it a host of new risks, including cancer, severe immune reactions and infections caused by the viral vector used to deliver the drug.

Parrish downplays such worries. There may be risks, she tells Robb Report. But the known risk is that youre 100 percent likely to die. So you have to decide for yourself if the potential benefit outweighs that.

Humans have always aspired to find the fountain of youth, so people might be skeptical about the fact that anti-aging technologies are working now, says British investor and businessman Jim Mellon. But the fact is that this is finally happening, and we need to seize the moment. Mellon cofounded Juvenescence, a three-year-old pharmaceutical company thats investing in multiple technologies simultaneously to increase the odds of bringing winning products to market.

Mellon, 63, has made his fortune betting on well-timed investment opportunities, and he predicts that a new stock-market mania for life extension is just around the corner. This is like the internet dial-up phase of longevity biotech, he enthuses. If youd invested in the internet in the very early days, youd be one of the richest people on the planet. Were at that stage now, so the opportunity for investors is huge. According to a report by Bank of America Merrill Lynch, hes not wrong: The market for technologies to increase human life span is projected to grow sixfold to $610 billion in just the next five years.

When I talk to Mellon in the late spring, hes sequestered on the rugged coast of the Isle of Man, a tiny spit of land in the Irish Sea. Despite being what he describes as imprisoned there for 15 weeksand countingduring the Covid-19 shutdown, hes jovial and chatty and wants to make it clear that his interest in life extension is much more than financial. Working to extend life is an ethical cause, he says. If we can help people to live healthfully until the end of life, well transform the world completely. Well reduce a huge amount of pressure on failing health-care systems, and well have to reimagine pension and life insurance. This should be the number-one tick in anyones investment portfolio.

If youd like to get on board with this social-impact view of longevity, it helps to understand the trajectory of aging today. In Americas most affluent neighborhoods, the average life span is about 88 years. (Meanwhile, in this countrys poorest, it hovers around a meager 66 because of a raft of inequalities, such as diet, stress, smoking, pollution and health care.) For most people, health starts gradually diminishing in the last 15 years of life with the onset of chronic conditions, including arthritis, neurodegeneration and diabetes. If we could eliminate such diseases of aging, experts say, the US could save an estimated $7.1 trillion in health-care costs over the next 50 years. (Quite where all these sprightly centenarians might live on this already densely populated planet remains to be seen.)

Jim MellonEric Verdin

One of Mellons bets is on a class of drugs called senolytics, which destroy senescent cells: the so-called zombie cells that, for complex reasons, stop dividing as we age. Senescent cells harm the body by secreting compounds that cause inflammation in surrounding tissues. Many age-related conditionsarthritis, diabetes, Alzheimers, cancerhave an inflammatory component, and studies suggest that a buildup of senescent cells is a large part of the problem.

A number of biotech start-ups are devel- oping drugs that target cell senescence, but the furthest along is Unity Biotechnology, a company in South San Francisco that has three drugs in clinical trials to address aging conditions, starting with osteoar- thritis of the knee. Unity raised more than $200 million from such big names as Thiel and Bezos, who chipped in through their investment firms, before going public in 2018. Since then, Mellon has also bought a small stake.

The holy grail of senolytics will be the development of a preventive therapy to wipe out senescent cells in the body before they cause conditions of aging, theoretically extending life span. In June, a team from Sloan Kettering published new breakthrough research showing that CAR T cellstypically used for precision cancer therapycan also be used to target and kill senescent cells. Prescription senolytics for anti-aging therapy are still years away, but unsurprisingly, theres an audience of longevity enthusiasts who want to access such anti-aging miracles yesterdayand no shortage of FDA-unapproved ways to chase after them. For instance, after a few studies examined the senolytic effects of a chemotherapy drug called dasatinib, the website FightAging.org published a step-by-step guide to senolytic self-experimentation using chemotherapeutics.

It doesnt take a Ph.D. in biochemistry to guess that taking off-label chemo drugs might come with harmful side effects, but that hasnt stopped a zealous group of body-hackers from trying it themselves and chronicling their efforts online. The internet is littered with novice longevity adviceand sketchy anti-aging companies eager to separate the hopeful and desperate from their money, like the company that charges $8,000 for transfusions of plasma from the blood of teenagers and early-twentysomethings (yes, just like Gavin Belson on HBOs Silicon Valley). Many of these are at best ineffective and at worst deadly, since the same cellular systems that fuel growth in young people might cause cancer when tipped into overdrive. Imagine the tragic irony of paying tens of thousands for a therapy that promises to help you live longer but actually causes the cancer that kills you.

Adobe

Beyond the obvious red flags of repurposed chemo drugs and the bloodletting of teens, it can be difficult for a layperson to separate the world-changing longevity breakthroughs from the terrible ideas. Enter one of the worlds leading experts on longevity to help make sense of things.

Eric Verdin, 63, is president and CEO of the Buck Institute, a globally renowned center for aging research just outside San Francisco in Marin County. Verdin is bullish on the promise of living healthfully to at least 100. Today. But 180? Dont count on it. My prediction, based on everything we know today, is that getting to 120 is about the best we can do for the foreseeable future. Ill bet my house were not going to see anyone live to 180 for another 200 years, if ever, he says. But making everyone a healthy centenarian, this is something we can do today. And thats something to be excited about.

Verdins own lab at the Buck Institute studies the aging immune system and how its affected by lifestyle factors, such as nutrition and exercise. Informed by this research, Verdin follows a time-restricted diet in which he eats all of his meals in an eight-to-nine-hour window (similar to the Buchinger Wilhelmi process) and gets plenty of exercise mountain biking in Marins steep hills. The good news is that over 90 percent of what causes diseases of aging is environmental, and that means its within your control, he says.

But he emphasizes that responsible management of your health comes with limits, like avoiding experimental therapies. A group of people have decided to try some expensive and dangerous interventions, but there is zero evidence that any of these are going to help them live longer, he says. The problem, according to Verdin, is that the results of aging interventions in mouse trials can look very promising but rarely translate to success in humans. Theres a huge delta between the health of a stressed lab mouse and an optimally healthy mouse, Verdin says. So when you treat lab mice with longevity therapeutics, you see an outsized result that doesnt at all guarantee the same result in humans.

On the other hand, Verdin tells Robb Report, there are definitely new protocols worth getting excited about. Take, for instance, rapalogs, a class of drugs that interact with a protein called mTOR, which serves as a linchpin for multiple critical biological processes, including cell growth and metabolism. Rapalog drugs tamp down mTOR, possibly preventing age-related diseases such as diabetes, stroke and some cancers. The drug rapamycin, the most heavily studied formula, was approved in the US in 1999 to help prevent organ-transplant rejection. Last year the medical journal Aging published a rapturous opinion piece by oncologist Mikhail Blagosklonny in which he made the case that rapamycinin small or intermittent dosesis effective as a preventive treatment to ward off diseases of aging, and that, in the elderly, not taking rapamycin may be even more dangerous than smoking.

Eric VerdinJim Hughes Photography

Later this year, a biotech firm called resTORbio, which was spun out of the Swiss-based Big Pharma company Novartis in 2017, is expected to seek FDA approval for its rapalog RTB101, which clinical trials have shown to slow age-related decline of the immune system and improve immune response in elderly people by more than 20 percent, a key factor in protecting vulnerable aging populations from disease. (It is currently in trials on elderly patients with Covid-19.) This is the furthest-along program of anything in the aging field, Joan Mannick, cofounder and chief medical officer of resTORbio, told MIT Technology Review last year. If health authorities approve this drug well have a product for people to prevent age-related diseases. Not just in our lifetime, but in, you know, a few years.

One of the many effects of rapamycin is that it mimics the mechanisms of calorie restriction. As Verdins lab and others have shown, fasting provides a number of anti-aging benefits, including insulin regulation, reduced inflammation and, to put it colloquially, clearing out the gunky by-products of metabolismpart of the reason Twitter CEO Jack Dorsey and other tech titans eat just a few meals per week. For lesser mortals, fasting is extremely hard to commit to and not much fun, hence the huge interest in calorie-restriction mimetics like rapamycin, which provide all the benefits without the downer not-eating part.

Of all the calorie-restriction mimetics, the one sparking the most excitement among longevity researchers is already on the market: metformin, a decades-old diabetes drug. Metformin became a part of the Silicon Valley health regimen several years ago after an epidemiological study showed that Type 2 diabetics who took the drug lived longer than non-diabetics who didnt. Just about everyone in the longevity industry takes metformin, Verdin tells me. He takes it himself, and nearly everybody I interviewed is taking or has taken it, too.

In April, Nir Barzilai, the renowned endocrinologist who spearheaded research on the anti-aging properties of metformin, announced in an opinion piece he co-authored in the journal Cell Metabolism that his lab is launching a large clinical trial to investigate the anti-aging effects of the drug on non-diabetic populations. Barzilais goal is to prove to the FDA that aging itselfrather than conditions associated with it, like Alzheimers and arthritiscan be targeted as a disease. If Barzilai is successful and the FDA approves aging as a treatment indication, the process of bringing longevity therapies to market would accelerate rapidly.

Just as the FDA was able to move faster to bring Covid-19 therapies to market this year, we will reach a tipping point when public opinion pushes the FDA to approve aging as an indication, and the longevity-research field will make leaps as a result, Mellon says. He has contributed funding to Barzilais metformin research, which he believes will be instrumental in proving that there are compounds that can extend human life across the board.

The fact of the matter is that the US has the best regulatory system for new drug development in the world, Mellon says. Were in the first era ever when humans can be bioengineered to live longer. And in 10 years, well have solutions that are even better than today. Just wait, its coming.

Liz Parrish

Jim Mellon

Diet:Vegetarian.Mindfulness practice:Nightly meditation.

Exercise regimen:30 minutes of cardio and 10 minutes of weights,five days a week.

Anti-aging Rx:Regenerative gene therapies. Im certain most peoplewill take them in the next couple decades.

180th-birthday wish:Solving another critical issue.

Sleep routine:7.5 hours plus a 30-minute nap; in bed by 9 p.m.

Vitamins/supplements/ prescription meds:Vitamins D and B12, metformin.

Exercise regimen:Walk or run minimum 10,000 steps a day;weights three times week.

Anti-aging Rx:Green tea.

100th-birthday wish:Another 25 years.

Dave Asprey

Jim Hughes Photography

180th-birthday wish:Either a cruise to Mars or a 1970 Mustang Fastback,which by then will be 210 years old!

Sleep Routine:Avoid: coffee after 2 p.m., heavy workouts after 6 p.m.,alcohol during the week and heavy eating in the evening.

Vitamins/supplements:Vitamin D, omega fatty acids, NMN, citrus bioflavonoidcomplex, fiber supplement, prebiotic supplement.

Diet:Fasting-mimicking diet once every four to six months;roughly 16:8 intermittent fasting at other times.

Mindfulness practice:Daily meditation.

Anti-aging Rx:I love cooking and eating, so I do not restrict foodon the weekend. Happiness with friends and family is thesurest path to longevity.

100th-birthday wish:A bike tour across the US, from coast to coast.

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The best anti-aging skin care products to use in your 40s – TODAY

For most of my life, Ive credited my good skin to two products: a gentle cleanser and a powerful sunscreen. But something happened when I hit my 40s I noticed my skin no longer glowed like it used to and it always seemed to look and feel dry. When I noticed a few sunspots on the top of my right cheek, I realized it was time to elevate my morning and evening beauty routines.

Fine lines, dryness, sunspots and a loss of firmness are all things women begin to deal with in their 40s, says Dr. Mona Gohara, associate clinical professor of dermatology at Yale School of Medicine. Plummeting estrogen levels directly affect collagen production, skin thickness and hydration, so its important to develop an anti-aging skin care program, and stick with that program, during this decade.

With so many anti-aging products on the market boasting ingredients youd never thought youd put on your face (acids! oils!), it can be hard to figure out where to start.

So we reached out to top dermatologists across the country to help simplify the process. Everyone we spoke to listed sunscreen as the most important topical to keep forty-something skin looking great, followed by the appropriate cleanser, anti-ager, moisturizer and exfoliator.

Below, you'll find a quick guide to what youll need when it comes to choosing the right ingredients for your face, because as Gohara stressed, At this age, prevention not just correction should still be your goal.

When shopping for a sunscreen in your 40s, experts note you should be looking for the words zinc oxide, titanium dioxide and iron oxide on the label.

Zinc oxide and titanium dioxide protect against both UVA and UVB rays, while iron oxide guards against skin-damaging blue light from computer and cell phone screens, notes Gohara. Look for an SPF of 30 or higher and slather on half a teaspoon on your face daily, including your ears and neck, before applying makeup. If you drive, be sure to protect your hands, as UVA rays can penetrate glass, resulting in sunspots.

EltaMD UV Facial Broad-Spectrum SPF 30+, despite having zinc oxide, doesnt leave your skin with a whiteish tint. It's also formulated with hyaluronic acid, which can help keep your skin hydrated and firm.

Supergoop! Unseen Sunscreen SPF 40 is oil-free, goes on clear and works as a makeup primer to control shine. The vegan formula should be applied as the last step in your skin care regimen before you apply makeup, at least 15 minutes before you step out into the sun.

Gohara recommends keeping this brush-on SPF powder in your glove compartment. With SPF 50, the water-resistant formula provides both protection and sheer tinted coverage.

In your 40s, derms recommend using a cleanser containing ceramides, glycerin, and vitamin E.

Ceramides are lipids that help retain moisture, glycerin is a humectant that pulls water from the deepest layers of the skin, while vitamin E also adds moisture, says Dr. Martha Viera, volunteer faculty at the University of Miami Department of Dermatology. Before cleansing, wash your hands thoroughly to avoid dirt or bacteria from touching your skin, and splash your face with lukewarm water prior to application to activate the cleansing ingredients. Start and end your day by washing with a quarter-sized amount of cleanser, applying it in a circular motion over your face and neck.

Viera likes La Roche-Posay Toleriane Hydrating Gentle Cleanser because its designed to balance the skins pH levels, protecting the skins sensitive barrier. It is formulated to cleanse the skin without stripping it of moisture thanks to ingredients such as glycerin and niacinamide.

Bioderma Sensibio Foaming Gel has a soothing gel-cream texture that turns to foam when activated. The gentle formula works to remove makeup while also hydrating the skin.

Dove White Beauty Bar with Deep Moisture is great for sensitive skin as it combines cleansing ingredients with a dose of moisturizing cream. It is suitable for sensitive skin and gentle enough to use on both your face and body.

Youll need two anti-aging products in your 40s: a morning serum that contains moisture-drawing hyaluronic acid and antioxidants, and a night serum that includes peptides and retinol (retinol should be applied at night as it can make your skin sensitive to the sun).

Be sure to layer your anti-ager under your moisturizer and consider a serum which, thanks to their small molecular makeup, absorbs quickly and deeply, says Dr. Arisa Ortiz, director of laser and cosmetic dermatology at the University of California at San Diego. Antioxidants like vitamin C, E, B5, and resveratrol attach themselves to free radicals, preventing the free radicals from latching onto and damaging healthy skin cells, while retinoids and peptides exfoliate dead skin while stimulating collagen and softening lines.

Obagi Professional-C Serum contains ascorbic acid, a vitamin C derivative that softens the look of pigmentation and encourages collagen growth. It can be applied to the face, neck and chest in the mornings and followed with sunscreen.

Dr. Ortiz likes Rodan + Fields Intensive Renewing Serum because its lightweight, absorbs easily and has the highest levels of vitamin A for a nonprescription product. The serums are held in small capsules that you can open to smooth all over your skin.

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This dermatologist-approved pick is suitable for normal, sensitive and dry skin. The formula works to not only visibly brighten the skin but also reduce the appearance of fine lines and wrinkles.

To tackle dry skin in your 40s, Gohora recommends looking for ingredients that help boost and maintain moisture, including niacinamide, ceramides, glycerin and hyaluronic acid.

To be most effective, apply your moisturizer after your anti-aging serum. Dot your cheeks, forehead, chin and nose, and then rub in a circular upward motion both morning and night, notes Dr. Paul Jarrod Frank, clinical assistant professor of dermatology at The Icahn School of Medicine at Mount Sinai Hospital and author of "The Pro-Aging Playbook."

This moisturizer comes in a soothing light gel-cream formula and uses hyaluronic acid to fortify the lipid barrier to prevent dryness. It can be applied twice daily after a serum is applied to the skin.

Pause Collagen Boosting Moisturizer contains skin-conditioning fatty acids and B vitamins that work to promote healthy skin. The formula features the brand's "Pause Complex," which combines vitamins, antioxidants and peptides that help boost collagen production.

Dr. Frank likes Caudalie Vinoperfect Brightening Moisturizer, a lightweight gel that contains niacinamide and hyaluronic acid for a boost of hydration. It can be applied in the mornings to the face and neck in order to brighten and moisturize the skin.

Acids in exfoliators help remove layers of dead skin cells to promote cell turnover, clear pores and reduce pigmentation. Look for words such as glycolic, lactic, mandelic or salicylic acid on the label.

Apply a dime-sized amount of facial exfoliator two to three times a week at night, Jarrod told us. Just dont overdo it too much exfoliation can rob skin of the fatty acids that protect the skin barrier.

This treatment addresses skin care concerns by exfoliating, purifying and smoothing the skin. Depending on your skin type, it can be used up to three times a week to improve the appearance of your complexion.

Dr. Frank likes Drunk Elephant T.L.C. Sukari Babyfacial, which has an eye-popping 25% glycolic and lactic acid blend to smooth and brighten skin. Since the formula uses clean ingredients, it is fragrance-free and won't leave the skin feeling irritated.

A derivative of salicylic acid can be found in Lancme Renergie Lift Multi-Action Ultra Milk Peel, a leave-on exfoliator that you apply after cleansing and before your moisturizer. The milky consistency feels smooth on the skin and should be applied with a cotton round.

Dermalogica Daily Microfoliant contains salicylic acid and foams up into a paste when activated with water. The formula can be applied daily to the skin to slough off dead skin cells and even out your complexion.

Although it is a bit of a splurge, this daily serum uses rich ingredients such as mandelic and lactic acid to unclog pores, even skin texture, reduce the appearance of fine lines and more. It can be applied to the face and neck to reveal brighter skin over time.

Bonus products: Our experts noted theres no harm incorporating a neck or eye cream into your routine in your 40s.

Look for targeted ingredients in a neck cream, such as tetrapeptides to promote collagen formation, antioxidant algae extract to protect against free radicals, glucosamine to stimulate hyaluronic acid and improve hydration while decreasing wrinkles, and omega-3 fatty acids to add moisture.

Apply a dime-size amount in the morning and evening, working your way up the neck to the jawline until the product is evenly distributed and absorbed, notes Gohara. Neck creams tend to be thicker than traditional moisturizers, so allow more time for them to absorb and be sure to follow up with a sunscreen in the morning.

Viera likes Revision Nectifirm Advanced, which uses peptides to smooth dry skin. Other ingredients such as lingonberry extract work with the skin's natural microbiome to provide soothing results.

Prai Ageless Throat & Dcolletage Creme has shea butter and hyaluronic acid to plump lines and effectively smooth the skin. For best results, the brand recommends applying the moisturizer twice daily to target areas.

Suzanne Somers Organics Neck Firming Crme contains tetrapeptides to support collagen and elastin growth. The formula is packed with skin-boosting ingredients such as hyaluronic acid and Swiss apple stem cells that help to combat signs of aging.

This cream can be applied twice daily in upward motions to hydrate and revitalize the skin. The formula is quick-absorbing, so it won't leave the skin feeling oily or greasy.

Look for ingredients like caffeine to reduce puffiness and dark circles, niacinamide and hyaluronic acid to plump fine lines, and arginine, growth factors, and retinol to boost collagen production.

Apply a pea-sized amount twice daily by gently patting the cream on with your ring finger, Viera said. Be sure to use any eye products containing retinoids at night to avoid sun sensitivity.

Dr. Viera likes Neocutis Lumire Illuminating Eye Cream, a lightweight cream that contains antioxidants to protect against environmental damage. In addition to its protective qualities, it can also be used to reduce the appearance of puffiness and dark circles.

RoC Retinol Correxion Eye Cream uses a derivative of vitamin A to accelerate the removal of dead skin cells, leaving you with visibly brighter skin. It targets concerns such as crow's feet, under-eye wrinkles, deep wrinkles and fine lines.

Skinbetter Science Interfuse Eye Treatment Cream contains caffeine to reduce puffiness and vitamin C to brighten the under-eye area. It is packed with humectants to help lock in moisture and promote healthy skin.

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12 Best Skin-Care Products for Mature and Aging Skin Dermatologist Recommendations – Allure

Although dermatologists see patients for a countless number of concerns (acne, suspicious moles, dandruff you name it), two of the most common appointment talking points are lines and discoloration. They're perfectly natural characteristics of skin that simply isn't as young as it used to be, but some folks would prefer to see themselves with a smoother texture and more even-toned complexion.

Dermatologists have access to some of the most effective in-office options, like injectable and laser treatments, but they also know what's up when it comes to topical products you can use in your everyday routine, like moisturizers, serums, and eye creams. And luckily, you don't have to visit a dermatologist every time you want to get a great product. (No offense, docs. We love our time together, but we also love the convenience of online shopping.)

Even more fortunately, you can still rely on their sage advice from the comfort of your home with this roundup of creams, serums, and specialty formulas that come highly recommended by some of the top dermatologists from all across the country. Below, you'll find line- and discoloration-addressing derm picks for every budget.

All products featured on Allure are independently selected by our editors. However, when you buy something through our retail links, we may earn an affiliate commission.

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11 Healing Revolutionary Herbs Used In Teas – Anti Aging News

Throughout history, herbs have been used for different purposes. Yet, there was no scientific information about their specific abilities in recorded history. However, this didnt stop our ancestors from using herbs for ingredients in teas, brews, and various meals for their healing purposes.

As modern medicine and technology have provided the ability to test the many health benefits of all sorts of herbs that are used in tea, lets look at ten of them and how they can help treat ailments and the body.

1. Ginger

Ginger is a popular herb present in many meals and drinks mainly as spice. Its health benefits are wide and significant. Using ginger for morning tea can help ease morning sickness in pregnant women. Other known benefits include preventing heart disease, decreasing the risk of cancer, and settling an upset stomach.

2. Cannabis

Many cannabis users know medical marijuana is best ingested by eating, smoking, or vaping it. Nonetheless, very few people are familiar with the less traditional methods of infusing it in tea. It is even considered a healthier and gentler way of introducing CBD or THC into the body than smoking.

Cannabis (marijuana or hemp) usage isnt a new innovation. Different cultures have used it for its therapeutic effects throughout history. If you have any throat or mouth conditions, or any respiratory diseases, cannabis tea is an excellent alternative that helps you prevent these risks associated with smoking.

3. Peppermint

A healthy body is usually stress-free with a well-functioning immune system. Peppermint tea is placed in high regard when it comes to stress and anxiety relief. Thus, placing less strain on your immune system and allowing it to work at prime condition. Peppermint Tea also facilitates sleep and can even help with bad breath.

4. Chamomile

Chamomile tea is rich with chamazulene, which possesses analgesic, anti-inflammatory, and antispasmodic properties. A hot cup of chamomile tea also treats colds, reduces period pains, and helps calm stomach aches. Its qualities are popular throughout Asia.

Additionally, the intake of chamomile tea helps reduce stress and aging. Both factors are regular problems people face daily due to the daily hassles of life. In all, chamomile helps boost the immune system in its way.

5. Hawthorn

This is a go-to herb for blood and heart issues. Drinking hawthorn tea promotes heart functions by first decreasing blood fats and stabilizing blood pressure. Both high and low blood pressure can be treated with hawthorn tea since the herb can serve as a vasodilator.

6. Ginseng

For centuries, Ginseng has been a traditional and popular herb in China. It is so popular in China that people subconsciously think of China whenever the name Ginseng arises in a conversation. The herb comes in three different types; white, red, and fresh.

The herb is beneficial for the body as it primarily boosts the immune system. Additionally, it contains relaxing effects similar to CBD, which is one of the reasons why CBD products are so popular. Yet, Ginseng is more known for its anti-inflammatory and antioxidant properties. The male reproductive system also enjoys excellent benefits from the regular intake of Ginseng.

7. Hibiscus

Hibiscus tea comes in different flavors due to the variations of the herb. However, its medicinal properties are all the same. Studies prove that the herb works well in lowering blood pressure and blood fat levels. Both conditions are threatening towards human life, as many lives are lost yearly due to these conditions.

Additionally, the intake of hibiscus helps boost your liver. Liver health studies have been conducted where hibiscus extracts provided protection qualities.

8. Cinnamon

Cinnamon is a great herb that can be beneficial to your health when taken sparingly. The presence of little coumarin can counter the health benefits including fighting off infections.

9. Echinacea

With a total of nine species, this herb has only three with healing qualities. The presence of active compounds in echinacea is impressive since the variety is outstanding. A few of such active compounds include phenolic acids, polyacetylenes, rosmarinic acid, and caffeic acid. Together, these active compounds make echinacea tea a healthy herbal drink by helping fight cancer cells.

10. Blackberry Leaves

The tannins and vitamin C levels are impressively high in blackberry leaves. Together, you can use blackberry leaves to tackle diarrhea and gastrointestinal inflammation. The combination also improves the immune system and speeds up tissue repair processes. This quality makes the herb great for recovery from open wounds.

11. Jasmine

Like other beneficial herbal teas, Jasmine teas burst with antioxidants. The Jasmine plant has a great aroma when infused with green, white, or black tea. Typically, Jasmine tea is made alongside green tea leaves, which merges with the herb to control weight.

The high presence of polyphenols in the herb is excellent for heart protection. These polyphenols also help lower the risk of Parkinsons and Alzheimers diseases. Jasmine tea, combined with cannabis products, prove to control Alzheimers effectively.

Conclusion

The healing qualities of herbs are great for the immune system. With different active ingredients and antioxidants, our list of ten healing herbs is noteworthy. Depending on your choice, theres bound to be significant health benefits from the herbal tea of your choice.

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I Went to Germany to Go on a 200-Calorie-A-Day Liquid Diet. Heres Why I Would Do It Again. – Robb Report

I should be miserable Id been cautioned: Watch out for day three. Thats when the demons begin to rage. Im on a medically supervised 10-day fast that promises to help me shed some weight while also futureproofing that newly slimmed-down body against aging. Worth the odd demon or a pang or two, then.

Indeed, Im a bit hungrybut thats not surprising, given that Ive consumed little more than tea, juice and soup over the past 48 hours. But I had been anticipating far worse, as several friends, all veterans of the Buchinger Wilhelmi process I am undertaking, had warned me. The real challenges in forgoing food wouldnt be simple hunger, they said. Fasting isnt the hard part, said one. Its the emotional side. I usually spend the third day curled in a ball in my room, weeping. Everything you repress just comes out, all at once. A second moaned about the physical side effects on day three for her: throbbing headaches, a furry tongue and dry skin, all because the toxins her body was purging began to crest, she said, wide-eyed. The consensus was that Id feel, generally, dreadfulnot just hungry but also sad, aching and exhausted, likely confined to my bed, wakefully toggling between napping and fretting. Yet another confided that it was day three when the risk of cheating peaked. Shed heard that folks usually skulk out the clinics back gate and into the nearby town to scarf down a furtive frankfurter or two to offset the gnawing pains.

Instead, I feel fine.

The pool at the Buchinger Wilhelmi clinic.Winfried Heinze

More than fine. Remarkably, I feel absolutely dandy. Ive no physical problems whatsoever; in fact, Im swimming 50 laps in the pool here at the Buchinger Wilhelmi spa every afternoon, and the only reason my eyes are watering is the troublesome pollen. I miss chewing, for sure, and Im not partial to some of the broth recipes: The mere mention of turnip evokes Dickensian deprivation, though the watery tomato is bright-flavored and delicious. But I havent cheated, despite deliberately wandering into town yesterday morning to tempt myself with the smells of fresh-cooked sausages. I took a deep breathdelicious for sure, but I was happy to eat with my eyes.

Either Im too two-dimensional to be troubled by deep thoughts or Im one of the lucky ones, sailing straight from eating three meals daily to the Zen state of semi-starvation without detouring down a physical and emotional rabbit hole. Ive arrived, instead, at 200-calorie nirvana, where the body, now short on fuel, is forced into overdrive. With my metabolism working harder to produce energy, I experience a new level of strength and mental clarity. I am Superman without the blue tights. In fact, the only challenge for me is my sleep. Usually, I slumber deeply and soundly anywhere, so its strange to find myself so fitful, with bouts of deep rest punctuated by an unfamiliar alertness. Otherwise, I nod sympathetically as I try not to gloat when folks mournfully complain in the feeding salon, the lounge-like area where our non-meals are devoured.

A suite at the Buchinger Wilhelmi clinic.Winfried Heinze

Its inside the salon that I first meet my fellow fasters on day one, at what passes for a welcome party at Buchinger Wilhelmi, on the shores of Lake Constance in Germany, just across the border from Switzerland. My fellow fasters are a motley bunch, drawn from across the world. Im surprised the room is equally split between men and women. There are several first-timers like me: a Saudi couple, for instance, well-padded fiftysomethings who plan to stay for three weeks. Other newbies include a pair of friends, fit, middle-aged financiers who usually take an adventure vacation together each year, leaving their wives at home. Most of the room, though, consists of starvation pros, folks whove followed the Buchinger Wilhelmi method several times before. Typical is the French sculptor whos back for a seventh stay. He became a devotee when his first stint allowed him to permanently shed the 40 pounds hed gained after a car accident. Tall and gaunt, he looks to be in his late 60s or older; hes come again, he explains, as an anti-aging effort. More than the chance to shed pounds, its this elusive promise that underpins the work at Buchinger Wilhelmi.

For this is no conventional fat farm. Forget face-lifts and fitness classesits bouts of fasting that Buchinger Wilhelmi claims will offer a slimmed-down path to eternal youth, or something close to it, at least. Fasting, the staff preaches, will better safeguard your body against the forces of age. The focus here, though, is not only extending your life span but also improving the quality of whatever life you have, or whats now known as your health span. The clinics practice aims to address a conundrum: How do we ensure our brains and our bodies remain in peak condition for our entire lives, bringing both quantity and quality of life in sync? Slash our daily energy source, Buchinger Wilhelmi posits, and the bodys metabolic switch is triggered. Deprived of easy fuel, our bodys metabolism instead turns to ketones, compounds produced from fats by our liver in a state known as ketosis, achieved by fasting at least 10 to 12 hours. Theres more afoot, too: During ketosis, the body starts to repair and reboot, helping bat away looming bad health. Per the clinics owners, eating 200 to 300 daily calories for several days, any time from your 20s to your 60s, isnt just good for your waistline; its an investment in the well-being of seventy-something you.

The Buchinger Wilhelmi clinic.Winfried Heinze

Theres no hardship here, though. The clinic doesnt resemble a traditional sanatorium but rather a five-star hotel. Scattered among several buildings on a steep hill, the rooms are decorated in muted tones and filled with tasteful, vaguely modernist furniture. One of the front-of-house staff is an alum of the Ritz Carlton in New York and proudly wears the lapel pin of Les Clefs dOr, the elite cabal of concierges. Theres a hair salon but no conventional luxury hotel-style spa. Instead, the clinic offers two main medical complexes, where the doctors and nurses on staff perform their examinations, plus numerous treatment rooms discreetly tucked into various buildings, where guests can book everything from osteopathy and shiatsu massage to outre rituals like Chi Nei Tsang, a Chinese abdominal massage, to pass the time between non-meals.

And, yes, the food. Other than at the start and end of your stay, when youll receive delicious, low-calorie vegetarian meals to help ease your digestive system into and out of hibernation, theres little to eat. (Dont confuse fasting-induced ketosis with a ketogenic low-carb, high-fat diet.) Breakfast is herbal tea and a tiny saucer of honey; keep it for the day, the nurse advises, and eat it sparingly when you need some energy. Lunch is fresh-squeezed juice, cut with more herbal tea to reduce its calories. Dinner is the aforementioned broth. Such scrapsor dripsof food leave my digestive system effectively fallow, though there are regular enemas from the nurse just to make sure. She also checks my vitals each morning, reminds me to drink at least six liters of water a day (to stay hydrated and prevent gout) and comes to my room every afternoon to wrap my liver, one of the quirks of the Buchinger Wilhelmi process: After what passes for lunch, youll spend an hour or more in bed, swaddled like a baby with a hot water bottle pressed to your liver. Per the clinics theories, such cosseting helps boost the livers ketone production process.

Breakfast: Tea With Honey (65 calories)Jenny Huang

The woman who helped formalize many such theories is Francoise Wilhelmi de Toledo, M.D. Trained as a conventional physician, she visited the clinic as a guest in her 20sand never left. After marrying into the family, she became the medical director. Toledo is now the clinics head of medical research and lives in a sleek glass box of a house nearby; one of her two sons, Leo Wilhelmi, handsome with a mane of dark hair, handles day-to-day operations. At 66, she has a gamine energy and a feline intelligence, and could easily pass for a decade younger. Doubtless, shed attribute her youthful glow to her decades-long adherence to fasting, both daily (in 16-hour windows) and twice yearly, when she follows the clinics regimen for 10 days or more at a stretch.

She invites me over for teafresh herbs, thyme picked from her gardenso she can explain the work here in person. Like the clinics staff and entire operation, the Swiss-born Toledo slides fluently between French, English and German as she talks; she has an evangelists charisma. Think of fasting as metabolic training, she urges, teaching the body how to use different energy sources, much as a hybrid auto switches between electricity and gas for efficiency. Hunger isnt to be avoided but rather deployed, a forgotten reflex that we need to relearn. Toledo is pleased that the clientele here includes so many men as well as womenthat 50:50 ratio is a rarity for conventional spas. Fasting is not easy, as we take away everything you like at the beginning, so its more of a challenge. Men like that, she says.

Indeed, it was a man who founded the clinic, a hundred years ago. His reasons were personal: Otto Buchinger, a physician, was wheelchair-bound from severe rheumatoid arthritis, at least until he fasted for almost three weeks on the suggestion of another doctor. Buchinger followed the most extreme protocols, ingesting only water. As a result, he later claimed, he was able to walk again. Buchinger turned his belief in the healing power of calorie restriction into his lifes work, setting up this clinic, which his descendants, including his great-grandson Leo, still run. But it is only in the last two decades or so that conventional science has turned its attention to the potentials of calorie restriction, and men have increasingly embraced fasting as the final fitness toola way to put their insides through as punishing a training regimen as they follow at the gym. Broadly speaking, there are two common approaches that aim to leverage reduced food intake for health and weight benefits. The first, periodic fasting, is the approach followed by the clinic; cut calories for an extended period every year or so, for example. The second is intermittent fasting, which deprives the body of nutrition in a given pattern each day or week: 16 consecutive hours in every 24 is popular (often called 16:8). Proponents claim both systems allow the body to shift into that sought-after state of ketosis.

Lunch: Freshly Squeezed Juice (50 calories)Jenny Huang

Peter Bowes is a longtime BBC journalist who periodically fasts in his role as host of the podcast Live Long and Master Aging. During fasting, he says, the body undergoes autophagy, or spring-cleaning mode, meaning it recycles damaged or old cell machinery. Studies suggest that this processwhich derives from Greek words meaning self and to eatcan even result in new synapses forming in the brain. When your immune system is challenged like this, it throws out the cells its not using, that are maybe a little weather-worn, Bowes says, and builds a new immune system, re-growing white blood cells.

A prolonged state of autophagy, then, could be thought of as a real-life counterpart to the serum that transformed scrawny Steve Rogers into super-soldier Captain America. Indeed, the US government has explored how to use intermittent fasting to improve the performance of elite commandos, according to Mark Mattson, a world-renowned expert in fasting and adjunct professor of neuroscience at Johns Hopkins University School of Medicine. Mattson says officials from NASA and the air force contacted him to discuss how to use his research in just this way. Its evolution, he says. If youre food-deprived, you need to be more alert and motivated to find foodthats why you often feel sleepy after a meal. He suggested using intermittent fasting as a training tool, spending two days per week, for example, drinking only water. Mattson has focused his studies on such intermittent fasts and has a hunch its more effective than the Buchinger Wilhelmi method of one long annual fast, though he recognizes the benefits of calorie-deprivation of any kind. His research includes clinical studies of individuals at risk of cognitive impairment from Alzheimers and similar diseases, in which he found that those on a diet that included fasting showed memory and learning improvements within two months. Mattson says intermittent fasting is also a promising component in cancer treatment. You should hit them in the fasting state with drugs or radiation because cancer cells cannot use ketones [as fuel], so if the glucose levels in the body are relatively low, it makes them more vulnerable, he explains.

Dinner: Broth (36 calories)Jenny Huang

Andrew Jenkinson, a London bariatric surgeon and author of Why We Eat (Too Much), does not recommend long-term fasting but is a proponent of the 16:8 approach. Ketogenesis is probably the best way to lose weight, but unfortunately, its difficult to sustain. Whatever diet you do for weight loss needs to be your new life, says Jenkinson, who recommends a low-carb diet. Fasting for a sustained period of time will improve the inflammatory response over the short term, and it will make you think faster and more clearlyit will give you a real buzz.

Experts differ on how long it takes for autophagy to kick in from intermittent fastingfrom right away to 12 weeksbut for optimal results, Toledo recommends practicing it five days a week. Jenkinson urges caution, too: Individual metabolisms and default weights vary. Veer from the program and youll likely rebound to where you started, he says. Though Toledo has led extensive in situ studies to determine the safety of the protocols used at the clinic, there are no records on the long-term efficacy of stays. The high ratio of repeat visitors could suggest that it is, indeed, hard to maintain such weight loss. Then again, it could be evidence of how effective her evangelical zeal proves in recruiting converts.

Im impressed, if not completely converted, by day 10. At my final morning check-in with the nurse, Ive lost close to 12 pounds and two inches from my waistline. More than anything, though, the stay here has changed the way I eat. I couldnt even finish the first meal of solids, post-fast, served up with a candle and certificate in celebration. Im just not as hungry as often anymore, and Ive adopted that 16:8 system most days. Three months later, even during lockdown with limited exercise, Ive remained slim. Would I come again? Absolutely. But perhaps the bigger question is: Why should I need to? Check back with me in a year.

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I Went to Germany to Go on a 200-Calorie-A-Day Liquid Diet. Heres Why I Would Do It Again. - Robb Report

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Re-Stem-Funded Study Targeting Mitochondrial Dysfunction in Aging and Age-Related Diseases Published in Science Advances Journal – Press Release -…

Aug. 9, 2020 / PRZen / SUZHOU, China -- Re-Stem Biotech (Re-Stem or the Company), a biotechnology firm engaged in the research and development of cell therapies targeting osteoarthritis, spinal cord injury and various cancers recently funded in part a study titled "Solid-phase inclusion as a mechanism for regulating unfolded proteins in the mitochondrial matrix". Researchers at The Johns Hopkins University School of Medicine, led by Rong Li, Ph.D., published their findings in the journal "Science Advances" (view full article here: https://advances.sciencemag.org/content/6/32/eabc7288) The study may provide mechanistic insights for mitochondrial dysfunction observed in aging and age-related diseases.

About Mitochondrial DysfunctionMitochondrial dysfunction is a hallmark of age-related diseases, such as cardiovascular diseases and neurodegenerative diseases. During aging, damaged/unfolded proteins in mitochondria that are failed to be degraded gradually accumulate. In addition, recent evidence suggests that non-mitochondrial proteins constituting pathological aggregates in neurodegenerative diseases also accumulate in mitochondria and cause mitochondrial dysfunction. However, it remains unclear how excessive damaged proteins are managed within mitochondria when known quality control mechanisms become inadequate, and how they contribute to mitochondrial dysfunction during the aging process.

About the StudyThe researchers discovered that excessive unfolded proteins in the mitochondrial matrix are consolidated into novel structures, which they named Deposits of Unfolded Mitochondrial Proteins (DUMP). DUMP formation is an age-dependent process, while accelerated DUMP formation causes mitochondrial dysfunction and premature aging. They found that DUMP formation was not random, but specific in mitochondria near endoplasmic reticulum (ER), another organelle in cells. The contact sites between mitochondria and ER regulate DUMP formation via transferring lipids between two organelles. Via a series of genetic and live-cell imaging studies, researchers identified key enzymes of mitochondrial lipid metabolism that control DUMP formation. Manipulation of these enzymes modulates DUMP formation, therefore, potentially they could be targets for anti-aging or treating age-related diseases.

About Re-Stem BiotechRe-Stem Biotech (Re-Stem) is a biotechnology firm engaged in the research and development of cell-based therapies and products. Backed by state of the art GMP facilities and an international team of world-leading scientists, doctors and management team, Re-Stem currently has a robust technology platform including four profitable therapies on the market and eight other therapies and products in the pipeline. Incorporated and headquartered in 2012 in Suzhou, China, Re-Stem is focused on the large and aging population of China. It also operates clinics and research and development laboratories in Shenzhen, Beijing, Kunming and Ganzhou. For more information visit Re-Stem Biotech website: https://www.restembio.com/

Forward-Looking StatementsStatements in this press release relating to plans, strategies, trends, specific activities or investments, and other statements that are not descriptions of historical facts and may be forward-looking statements are inherently subject to risks and uncertainties, and actual results could differ materially from those currently anticipated due to a number of factors, which include those regarding our ability to implement objective, plans and strategies for future operations. Forward-looking information may be identified by terms such as "will," "may," "expects," "plans," "intends," "estimates," "potential," or "continue," or similar terms or the negative of these terms. Although Re-Stem believes the expectations reflected in the forward-looking statements are reasonable, it cannot guarantee that future results, performance or achievements will be obtained. Re-Stem does not have any obligation to update these forward-looking statements other than as required by law.

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Re-Stem-Funded Study Targeting Mitochondrial Dysfunction in Aging and Age-Related Diseases Published in Science Advances Journal - Press Release -...

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