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Category Archives: Anti-Aging Medicine
By tweaking a few key genes in the DNA of a roundworm, scientists have extended the animal's life span by about 500%.
That's a huge jump in life: An average roundworm lives for about three to four weeks. But when unencumbered of two specific genes DAF-2 and RSKS-1 the creatures can survive for several months.
Scientists had linked these genes to longevity years ago, noting an increase in the life span of worms and other creatures when these genes are switched off. However, the exact role of the genes in the aging process remained a mystery.
Now, researchers have connected the dots between these two genes and mitochondria, the tiny powerhouses that fuel cell function throughout the body. Mitochondria begin to malfunction as an organism ages, but silencing DAF-2 and RSKS-1 seems to delay this damage and extend life span at least in roundworms, according to a study published in 2019 in the journal Cell Press.
Only time will tell if the anti-aging remedy could work in mammals, including humans.
Related: Extending Life: 7 Ways to Live Past 100
Scientists first realized the link between DAF-2 and aging in the early 1990s, when a research team discovered that roundworms live twice as long as normal when they carry a mutated version of the gene. The finding jump-started a new era in the study of aging, one driven by genes and their byproducts.
"It was like a game-changer in the field because people started believing that a single gene can extend life span," co-author Pankaj Kapahi, a professor at the Buck Institute for Research on Aging in Novato, California, told Live Science.
Over time, research groups uncovered more longevity genes, including RSKS-1, but mounting evidence suggested these special segments of genetic code don't work in isolation. Instead, they coordinate with a team of other genes and the proteins that they help to build, triggering cascades of cellular activity known as "signaling pathways." Think of signaling pathways as rows of dominos when one domino topples, it falls into another and sets off an intricate chain reaction.
DAF-2 and RSKS-1 each sit within an important signaling pathway, respectively: the insulin signaling pathway, which helps control blood sugar levels and metabolism, and the TOR pathway, which alters how cells build proteins and thus how they grow and proliferate. But how these pathways intersect in an aging organism was not known, Kapahi said.
Related: 5 Reasons Aging Is Awesome
To uncover where this anti-aging effect comes from, Kapahi and his colleagues spied on the cells of mutant roundworms, in which both of those genes had been turned off. Using a technique called "polysomal profiling," the team could track which proteins the cells were building at any given moment. During protein construction, cells can employ various mechanisms to ramp up production of a particular protein or dial it back. The team found that, in mutant worms, cells built far fewer copies of a protein called "cytochrome c" than normal worms.
Here's where mitochondria come into the picture:
Cytochrome c appears in the inner membrane of mitochondria and helps pass negatively charged electrons through its structure. This transfer of electrons from protein to protein allows mitochondria to generate fuel but in mutant worms, a gap appears where cytochrome c should be. Unable to make fuel as efficiently as they would normally, the mitochondria dial back energy production and instead focus on repairing damaged tissues.
As energy stores fall, a fuel-sensing enzyme called AMPK kicks into high gear, helping the worm switch to a more efficient form of energy metabolism. This complex chain of events ultimately produces a long-living roundworm whose cells stay healthy and largely damage-free well into old age.
"Proteins get damaged with age, and you see less damage with these pathways inhibited," Kapahi said. In addition, research suggests that certain tissues, such as those in the muscles and brain, may even grow healthier as long as these pathways remain stifled, he added.
Overall, the mutant worms dialed back both protein and energy production in favor of repairing their aging cells. Specifically, a lack of cytochrome c in the animals' reproductive cells seemed key to this process, the authors noted. It may be that the worms put processes related to reproduction on hold while in low-energy mode, they said.
Organisms react similarly when pushed into starvation mode without adequate nutrition, cellular signals tell the body to take a "time out" from preparing to produce offspring, Kapahi said. This idea is also supported by the 1990s study of old roundworms; In that study, the mutant worms lived twice as long as normal worms, but they also produced about 20% fewer offspring.
Far from being a passive process, aging in the roundworm seems to involve a messy tangle of biological pathways that work together to regulate metabolism, protein construction and potentially reproduction. Although similar pathways exist in humans, scientists still don't know if aging works the same way in both organisms, Kapahi said. If anything, aging in humans may prove more complex.
Related: 8 Tips for Healthy Aging
"Conservation isn't absolute and important differences in these pathways between worms and mammals exist," Dr. Joseph Avruch, a professor of medicine at Harvard Medical School and chief of the diabetes unit at Massachusetts General Hospital, told Live Science in an email.
While tamping down signaling in the insulin and TOR pathways seems to extend the life span of worms, it's unclear whether humans would have the same response.
"If the gene network identified here ... functions similarly in mammals, then pharmacologic interventions become feasible," Avruch said. In other words, the anti-aging experiments first conducted in worms must be replicated in mammals before anyone will know if they could possibly work in humans.
The pathways involved in the aging process "might be something very specific to the worm," Kapahi said. "But we'll never know if we don't ask these questions."
Originally published on Live Science.
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Gene Tweak Can Extend Life 500% (But You Have to Be a Worm) - Livescience.com
Ever wish you could sneak a peek inside the medicine cabinets of a dermatologist? Now you can!
TODAY interviewed 12 professionals about the anti-aging products they actually use to keep their skin looking young. From a $13 over-the-counter retinoid to a skin-brightening vitamin C serum, keep reading to discover the skin care secrets dermatologists swear by.
Dr. Melissa Kanchanapoomi Levin, board-certified dermatologist and founder of Entire Dermatology in New York City, can't speak highly enough about Differin Gel.
"It used to be a prescription and then it went over the counter I love Differin gel," she said.
Thanks to powerhouse ingredient retinoid, this gel doesn't just fight acne, it also helps reduce signs of aging. It works by reducing inflammation deep in the skin to clear clogged pores and combat fine lines.
"When I think of anti-aging, I think of protecting, preventing and correcting, so I always like to have an antioxidant in the morning," Dr. Michelle Henry, Clinical Instructor of Dermatology at Weill Cornell Medical College in New York City, said.
She recommends La Roche-Posay's vitamin C serum because it helps brighten skin, get rid of dark spots and stimulate collagen. "It makes skin look fresher and gets rid of lines and wrinkles," she added.
Dr. Henry calls hyaluronic acid a "miracle molecule" and this serum is chock-full of it. "It really helps plump up your skin," she explained. "As we get older, we lose hydration in our skin and this ingredient can help restore moisture."
New York City-based dermatologist Dr. Dina Strachan says she and her patients love this product for getting rid of dark spots and fine lines. It was formulated as an alternative to the skin lightening ingredient hydroquinone.
Its safe to use the long term because it doesnt bleach the surrounding skin. Its also packed with powerful anti-aging ingredients like kojic acid and licorice root extract, which fight free radicals that damage collagen," she explained. "It can be applied once or twice a day, just be sure to use a sunscreen with this product."
I love this product because its sensitive enough for first-time retinol users," said Dr. Kim Nichols, a Connecticut-based dermatologist.
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"Retinol, a derivative of vitamin A, does a lot. It minimizes fine lines and wrinkles, diminishes hyperpigmentation, blackheads and dark spots and reduces inflammation, pore size and the appearance of blemishes," she said, adding that it's not too harsh on skin. "Two things to remember when using retinol: Always use with a moisturizer and less is more," she noted. "You only need a penny size for your whole face at night.
I started researching natural skin lines a few years ago when I was looking to replace my underperforming hydrating gel. Thats when I discovered this gel and serum combo. I was initially attracted to the hypoallergenic and nontoxic nature of these two products, but after I tested them, I was immediately drawn to their silky texture and smooth application and their results," said Dr. Jessica Weiser, a New York City-based dermatologist.
"I apply the serum every morning its powerful antioxidants brighten my complexion and help prevent UV and environmental damage. Then comes the gel, which contains hyaluronic acid, which gets set over the smaller molecular nutrients and vitamins in the serum. The combination leaves my skin glowing, radiant and perfectly prepped for sunscreen, the final and most important step of my skin care routine.
I swear by retinoids! Every dermatologist learns about this form of vitamin A in residency as part of our training. As an anti-ager, retinoids help soften wrinkles and lines and decrease pigmentation caused by the sun. But they also treat breakouts and stimulate collagen and elastin fibers. Want more? Retinoids can improve pigmentation issues, like brown spots and melasma, thanks to its exfoliating properties and they can shrink the size of your pores and give your skin a glow," said Dr. Gary Goldenberg, assistant clinical professor of dermatology at the Mount Sinai Hospital in New York City. "Any product that's left on my fingers goes right to the backs of my hands for some anti-aging there.
Dr. Henry is a fan of this cream that took over a decade to develop because it's made with retinol and won't irritate skin. "It also has some Vitamin B3," she noted. "The combination helps to not only get rid of fine lines and wrinkles but also helps lighten dark spots and give the skin hydration It's a really nice drugstore retinol," said Henry.
While there are many expensive skin care treatments on the market, nothing is better at preventing both skin cancer and premature skin aging than sunscreen. Studies have shown time and time again that regular use of sunscreens prevents the development of skin cancers, including melanomas, which can be potentially fatal. In one recent yearlong study, regular sunscreen use was even shown to improve the cosmetic appearance of the skin, likely because protective skin was able to heal itself. The best treatment for aging skin is preventing ultraviolet light damage to begin with. Skipping one day will not result in too much loss, but if you regularly take a pass, your skin will ultimately pay the price," said Dr. Joshua Zeichner, director of cosmetic and clinical research, Department of Dermatology, The Mount Sinai Hospital.
"I was introduced to this product when I was a resident. I love that it not only protects from UV exposure, but its the one product that really brightens up the skin, thanks to its soy complex and light diffusers.
I love this anti-ager because its dual acting: Its an oil- and fragrance-free moisturizer, plus its a broad spectrum UVA/UVB sunscreen that contains zinc oxide and titanium dioxide but doesnt leave your skin looking pasty and chalky," said Dr. Sonia Badreshia, clinical instructor of dermatology at the University of California, San Francisco. "It's a must-wear for your face, neck, dcollet and hands. I recommend it to treat and prevent dark marks and its my secret weapon for fighting rough knees and elbows."
This is the best anti-aging product in the drugstore!" said Dr. Diane S. Berson, associate clinical professor of dermatology, Weill Medical College of Cornell University New York-Presbyterian Hospital.
She says the combination of ingredients in the formula address most concerns associated with premature aging like dull skin tone, texture and wrinkles.
"This product has been evaluated in clinical trials in fact, one study published in the British Journal of Dermatology showed that it was as effective as Renova, an FDA-approved prescription product for the treatment of wrinkles," she raved. "Applied at night, its the perfect solution for those who want an effective anti-aging product in one jar.
Dr. Levin recommends this combination moisturizer with SPF 30. "It has three essential ceramides that really hydrate and protect the skin barrier. It also has a hyaluronic acid which is a super hydrating skincare ingredient that I love," she explained.
If you have dry skin during the winter months, Avne Tolerance Extreme Emulsion cream may be the product for you. "I really like Avne during this time of year," Dr. Levin said.
The lightweight moisturizer hydrates skin without leaving a greasy residue, so you can easily layer it under your makeup.
I've been applying hyaluronic acid to my skin for years," said Dr. Rachel Nazarian, assistant clinical professor at The Mount Sinai Hospital Department of Dermatology. "Its a substance naturally found in the skin and works to maintain water for a fuller, more youthful look."
"Its unique, moisture-binding feature allows it to hold many times its own weight in water. I used to apply a high-grade version of hyaluronic acid topically to my face, but the molecules were large, making it difficult for them to absorb into my skin. Today, smaller molecules of high-grade hyaluronic acid with better topical absorption capabilities can be found in over-the-counter products, including this gel-cream that I apply nightly. Bonus: Its hydrating properties curb the irritation caused by retinols," she continued.
"I still use a few tricks to enhance absorption, such as applying it after I shower while my skin is still damp or using it after an exfoliating wash."
Sunscreen is the most important anti-aging product because the sun is responsible for 90% of skin aging," said Dr. Arielle Kauvar, a New York City-based dermatologist and clinical professor of dermatology at Langone NYU Medical Center.
"This is my favorite face sunscreen because it doesnt irritate even the most sensitive skin we even use it on patients after laser procedures. Its water-resistant and adds a light tint to your skin, which is great for when you want to go sans makeup. I apply it after my moisturizer and before my makeup. Just be sure to reapply if youre outdoors all day,
This sheer, tinted sunscreen goes on smooth and acts as a great, lightweight primer before makeup, smoothing out any skin imperfections. It's also a great product to use at the beach when you don't want to wear heavy concealer and foundation, but still want a little coverage, said Dr. Sherry Ingraham, a Texas-based dermatologist.
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16 best anti-aging products of 2020 - TODAY
The Katz JCC in Cherry Hill is pleased to announce that IVNation, New Jerseys premier mobile IV therapy company, will open a location in the JCC Fitness Center this month.
IVNation was created by a group of emergency medicine physicians and nurses whose years of experience managing the sickest of patients on the front lines led to their passion for and commitment to promoting and delivering wellness, hydration, and recovery to the public. IVNations staff of licensed and experienced medical professionals combines treatments and techniques practiced in ERs with the most up-to-date nutritional and hydration therapies, now offered in the comfortable setting of the JCC.
Were thrilled to be partnering with the Katz JCC and for the JCC to be our first Cherry Hill brick and mortar location, said Dr. Justin Skolnick, co-founder of IVNation. The Katz JCC has been an important part of my familys life for many years and it is great to be able to give back to the JCC community. At IVNation, we realize that almost 75% of all Americans are chronically dehydrated and another large percentage are deficient in several essential vitamins and minerals necessary to carry out our bodys most basic functions. By reviewing your medical history, diet and lifestyle, we will be able to tailor a vitamin and nutrient infusion that is just right for you. IV infusion and booster therapy benefits people of all ages and with a wide variety of health, wellness and fitness goals.
Co-founder Dr. Brian Morgan added, We pride ourselves in working with our clients to customize treatment regimens tailored to meet their needs and deliver these services in a safe, efficient, and comfortable manner. The JCC vision and community is something near and dear to us and we are excited for the opportunity to offer this unique therapy there.
Services to be offered include intravenous hydration therapy, vitamin and anti-aging infusions and antioxidant boosters like the highly desirable B12 shots. In addition to hydration therapy, IVNation also treats several acute and chronic illnesses like migraines, muscle cramps, stomach bugs, flu symptoms, and inflammatory pain syndromes. Feel free to stop in after a fun night out for detoxification and hangover relief therapy. Cutting edge NAD+ infusions which offer benefits for anti-aging, chronic fatigue, chronic pain, neurocognitive function, substance abuse recovery and many other benefits, will be available as well.
Stop in during business hours to discuss which treatment may be best or to have a quick and complimentary blood pressure check.
IVNation will be located in a private room right in the JCCs Fitness Center, with weekly hours beginning Sunday, Feb. 2.
To make an appointment or learn more, please call (856) 281-7134 or visit http://www.ivnation.com.s
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Katz JCC partners with IVNation to offer IV hydration and wellness - Jewish Community Voice
NutriDrip, ahead of funding round, sets up aging and hangover treatments at Wynn Hotels, Equinox – CNBC
At Clean Market in Midtown, New Yorkers have a wide menu of healthy offerings to choose from, such as "superfood smoothies" and bowls with a side of a "moon dust of choice."
But if clean food isn't enough, customers can also get a boost from vitamins delivered intravenously at the NutriDrip bar. The service is growing in popularity and attracting customers from fitness and lifestyle companies like Equinox to some major hotel chains.
NutriDrip sells 15 vitamin infusions administered by medical professionals via an IV drip that takes about 30 minutes. The Nutribody drip aims to support fat loss with a combination of l-carnitine, taurine, vitamin C, B complex, among others. There are also the popular hangover remedies Basic Recover, Super Recovery and Mega Recovery which range in price from $119 to $199 depending on how much you're hurting from the night before. The Nutriyouth drip claims the ability to "help stop cellular aging in its tracks" with a mixture of anti-aging enzymes, molecules and vitamins for $599.
Founded five years ago, NutriDrip is looking to expand in 2020 with a Series A funding round in the first half of this year. Executives declined to say how much money they're looking to raise.
"Over the last three years, IV nutrient therapy, specifically NutriDrip, has grown, at like a 60 to 80% year-over-year growth rate, even while opening new stores," said co-founder Asa Kitfield. "So we're really excited to see what sort of saturation the market can see on like a local and national basis."
One of its new corporate clients is Wynn Hotel will be offering NutriDrip IV drips to its guests in Las Vegas in early 2020.
A woman receives a vitamin infusion via intravenous drip.
Carlos Allegri | Reuters
"As many of our guests now expect a more holistic set of wellness options, we have evolved to include broader wellness themes related to functional wellness, physical fitness, and healthy cuisine," said a Wynn spokeswoman, adding "providing IV therapy is one more way to help our guests maintain personal wellness routines while they are traveling."
The Equinox Hotel in Hudson Yards also has been offering the service to guests when it opened last summer. Kitfield also told CNBC, NutriDrip is slowly rolling out the service to other Equinox gym locations in early 2020 as well.
Equinox executives Jeffrey Weinhaus and Harvey Spevak were early investors in NutriDrip parent company Clean Market, along with real estate investor Jack Terzi, Seritage Growth Properties CEO Ben Schall, fashion designer Andrew Rosen and venture capital firm Able Partners.
Celebrities, including Madonna, Rihanna and Simon Cowell, are reportedly fans of IV vitamin treatments, but it's drawn some controversy.
"Anytime you poke a hole in somebody's vein, there is some risk that they'll bleed excessively. There's also some risk that they will clot excessively," said Dr. David Katz, founding director of Yale University's Prevention Research Center. "So the risks are not great. And the risks are not very common, but there are risks, and the only way to justify any risk in medicine is by a greater likely benefit."
He said there is "minimal evidence that there is any meaningful benefit for most people."
Kitfield said NutriDrip doesn't make grand promises about its treatments but said the company and customers clearly believe in its benefits.
"When you look at our business where 50 to 60% of our revenue comes from regulars, and that's why we continue to grow, the proof is kind of in the pudding, Kitfield said.
According to the Global Wellness Institute, a nonprofit that tracks the industry, the global wellness market is a $4.5 trillion industry. While IV therapy and alternative medicine is a small portion of the overall spending, GWI says it's among the fastest-growing sectors.
Whats the Difference Between Windows 7 and Windows 10?
Released on July 29, 2015, Windows 10 is now the operating system of choice for more than 61 percent of all Windows-based PCs.
In some ways, the design looks forward and back: Unlike recent iterations, the latest version marks a return to the classic Start Menu for access to applications and it also includes Live Tiles that show relevant, real-time data (a nod to Windows 8 functionality).
In addition, Windows 10 streamlines search and notification functions with a dedicated search bar at the bottom of the desktop and notification center in the bottom-right corner, making it easier for users to search, schedule upgrades or make changes.
Its also notable for incorporating virtual desktops, automatic updates and improved security. A detailed rundown in BizTech explains these and other points to consider.
READ MORE: The Complete Business Guide to Windows 10
A Windows 10 rollout requires advance planning and team cooperation to successfully execute. That outcome is especially critical in healthcare, an industry prone to hacking and whose mobile tools are increasing in use and number.
Among the questions that businesses should be asking:
Making sure all stakeholders are educated and aligned before a kickoff is critical, notes technology consultant and Microsoft Certified Systems Engineer Russell Smith, who addresses these issues and more below.
READ MORE: 5 Essential Questions to Answer for a Smooth Windows 10 Migration
Enhanced security functions found in Windows 10 are key to helping protect medical data and devices from harm. They include:
Windows 10 includes tools for smarter browsing and collaboration, including the Microsoft Edge browser. Users can annotate web pages using a keyboard or a stylus pen on the touch screen of a Microsoft Surface tablet, and share the notes. The software also works faster than its predecessors, thus boosting productivity.
In addition, Microsoft recently announced new Teams features that include advanced messaging capabilities, such as priority notifications and message delegation. The features also can integrate electronic health records for better care coordination.
READ MORE: How Windows 10 Can Improve Healthcare Collaboration, Communication
A Windows 10 transition doesnt happen overnight, as a HealthTech profile of several hospitals and clinics making the move have found.
Kelsey-Seybold Clinic in Houston spent two years preparing for a migration. The systems IT staff made the shift look easy but the process required infrastructure upgrades, training and painstaking work to ensure applications would be compatible with the new operating system.
Similarly, Michigan Medicine opted to replace 70 percent of its 35,000 aging computers to ensure Windows 10 compliance and usability. To tackle the massive task, the medical system hired a third party to warehouse and unbox new equipment; it also created three internal teams to manage progress across facilities.
Allegro Pediatrics in Washington state also started early, by allowing some doctors to test and familiarize themselves with computers equipped with Windows 10 before a companywide rollout. It was one of the easiest transitions Ive ever been part of, says Brock Morris, Allegros CIO and chief marketing and communications officer.
READ MORE: Healthcare Organizations Face Hurdles as They Move to Windows 10
Windows 7s end of life has massive implications for healthcare organizations, many of which havent updated their supporting infrastructure for medical devices due to longer device and vendor lifecycles.
Also complicating matters: a number of medical device manufacturers continue to ship devices that have computers running Windows 7.
A critical step is isolating and segmenting legacy Windows 7, Server 2008 and older devices so they dont communicate with the rest of the network unless absolutely necessary. Network segmentation also reduces the attack surface and can prevent attackers from probing and pivoting across the network.
Provider organizations should also develop solutions to run applications that cannot be updated to newer versions of Windows remotely. Its possible to run these applications on an isolated environment and use a tool like Microsoft RemoteApp to display them on newer PCs.
READ MORE: Device Security Must Be Top of Mind for Providers During a Windows 10 Migration
Free Health Seminar: IMPROVE YOUR COMPETITIVE EDGE: MOBILITY & STAMINA IN FITNESS AND SEXUAL HEALTH – Villages-News
2nd in the 2020 3-part wellness series, and one of Dr. Millers most sought after speaking topics. Learn ways to increase strength, mobility, balance, stamina, and muscle recovery after exercise, AND hear information that can significantly improve sexual health as you age.*Come early for best seats, doors open at 2:30pm.
Free health & wellness seminar by international speaker and PBS health series featured expert, Board Certified Anti-Aging & Functional Medicine physician, Dr. Kristin Miller, MD, FAARM, FAAMFM. Event co-hosted by Tim Taylor, President of Care Beyond.
Dr. Miller has been a practicing physician, owner, & medical director of multiple medical practices with a focus on holistic, patient-centered, evidence-based medicine combining principles of Western and Eastern medicine. She has been medical director of Medi-Spas establishing protocols and focusing on advanced techniques of skin rejuvenation and BoTox & filler injection treatments. Dr. Millers integrative approach includes state-of-the-art laboratory testing methods and development of customized treatments, including nutritional and lifestyle modifications, pharmaceutical grade nutrients and herbs, and collaboration in the development of new compounded neutraceuticals. The goal for treatment is to assist the bodys natural pathways to return to a more healthy, balanced state for optimal health at any age.
Dr. Miller has written extensively in patient-focused health journals. She has published peer-reviewed articles and has spoken at many medical meetings and seminars throughout the United States and abroad. She has been featured in the media and is internationally known as an expert in the field of Anti-Aging, Metabolic and Functional Medicine.
Dr. Millers focus is now to reach beyond the clinic doors, to share innovative evidenced-based information about health and wellness so you can make the best choices for YOU. She currently works with a non-profit foundation in California whose focus is wellness education and giving back to the community, providing financial assistance for healthcare to those in need.SAVE THE DATE: MARCH 1st: Part 3 of the 3-part series: UNLOCK YOUR MEMORY POTENTIAL