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BEIJING, Jan. 8 (Xinhua) -- For the first time, a genome-wide CRISPR-based screening technology has identified a new driver of cellular senescence. It can form part of new strategies to delay aging and prevent aging-associated diseases, Chinese researchers said.
By screening and identifying more than 100 genes responsible for the aging of human cells, the research team demonstrated that knocking out, or disabling, some genes by CRISPR can discourage the aging of human mesenchymal precursor cells (hMPCs). Among the genes that lead to senility, and KAT7 (a histone acetyltransferase), is one of the catalysts for aging.
Knocking out KAT7 has been proven effective in alleviating cellular senescence in the team's experiments, said Zhang Weiqi, a researcher at the Beijing Institute of Genomics under the Chinese Academy of Sciences. The scientists managed to reduce the proportion of the senescent cells in the livers of aged mice and prolonged the lifespan of physiologically aged mice and those with progeria.
The novel gene therapy, based on disabling a single gene or using KAT7 inhibitors, could extend mammal life. It could also slow down the aging of human liver cells. It suggests a massive potential for its application in translational medicine against human aging.
The study was published on Thursday in Science Translational Medicine online.
Global Medical Aesthetics Market Overview By Size, Share, Trends, Growth Factors and Leading Players With Detailed Analysis of Industry Structure -…
DBMR has added a new report titled Global Medical Aesthetics Market with analysis provides the insights which bring marketplace clearly into the focus and thus help organizations make better decisions. This Global Medical Aesthetics Market research report understands the current and future of the market in both developed and emerging markets. The report assists in realigning the business strategies by highlighting the business priorities. It throws light on the segment expected to dominate the industry and market. It forecast the regions expected to witness the fastest growth. This report is a collection of pragmatic information, quantitative and qualitative estimation by industry experts, the contribution from industry across the value chain. Furthermore, the report also provides the qualitative results of diverse market factors on its geographies and Segments.
Global medical aesthetics market is projected to register a healthy CAGR of 12.1% in the forecast period of 2019 to 2026.
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Aesthetics devices are an innovative advancement, providing a solution to patients which deal with the ingenuity of creating beauty. The medical aesthetics devices is a growing market owing to its benefits such as maintaining the youthful appearance, pain free and non-invasive beauty treatments, maintenance free skin that remains smooth and hairless without the need for shaving, waxing or unpleasant hair treatments, improving the cosmetic appearance, and technological advancement in medical aesthetics devices.
The market is showing a substantial growth in the emerging countries as these countries are adapting to the trends of urbanization. Brazil, South Africa, Thailand and many others have improved in the past one decade. People are opting different aesthetics surgeries to maintain themselves, which give them better results without any stressful physical efforts. Medical Aesthetics is one of the most trending concepts of the 21stCentury which will show a substantial increase in the future as there is a great technological advancement and innovation in the field by the companies dealing with these devices making them safer and even less invasive leading to more population opting for these procedures.
Competitive Analysis: Global Medical Aesthetics Market
Some of the major players operating in the global medical aesthetics market are Allergan, Bausch Health Companies Inc., Lumenis, Shanghai Fosun Pharmaceutical Group Co. Ltd., Cynosure, Syneron Medical Ltd, Aerolase Corp., A.R.C. Laser Gmbh, Asclepion Laser Technologies Gmbh, Btl, Cutera, Eclipse, Lutronic, Mentor Worldwide Llc, Merz Pharma, Quanta System, Sciton Inc., Sharplight Technologies Inc, Syneron Medical Ltd., Venus Concept.
Segmentation: Global Medical Aesthetics Market
Global medical aesthetics market is segmented into 4 notable segments such as product type, type of care, accessories and end user
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The company was founded in 2013 and headquartered at Dublin, Ireland. The company is focused on developing, manufacturing and commercializing branded device, biologic, pharmaceutical, surgical and regenerative medicine products for patients throughout the world. The main business segments are US Specialized Therapeutics, US General Medicine, International. The revenue of the company in healthcare sector 2018 was USD 16,550.8 Million. The company has global presence in North America, Asia Pacific, South America, Europe and Middle East & Africa.
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Bausch Health Companies Inc.
The company was founded in 1959 and headquartered at Quebec, Canada. The company is engaged in manufacturing and marketing a broad range of branded and generic pharmaceuticals, over-the-counter (OTC) products and medical devices. The main business segments are Bausch + Lomb/International, Branded Rx, U.S. Diversified Products. The revenue of the company in healthcare sector 2018 was USD 8,174.8 Million. The company has global presence in North America, Europe, the Middle East, Africa, Asia Pacific and Latin America.
The company was founded in 1991; headquarter in Yokeneam, Israel. The company is engaged in the field of minimally-invasive clinical solutions for the Surgical, Ophthalmology and Aesthetic markets, and expert in developing and commercializing innovative energy-based technologies, including Laser, Intense Pulsed Light (IPL) and Radio-Frequency (RF). The company has global presence in North America, South America, Europe, Asia, Africa and Australia.
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Its an undeniable truth that aging is inevitable. Isnt it? What if almost everything weve been taught about aging is wrong? What if we could change how long we live? In other words, could we choose our longevity by having better healthspan?
Statistics show that the age of our community is rising, especially in the developed world. In 2017, one in eight people worldwide was aged 60 and over. In 2050, older people are projected to account for one in five people globally. So, by 2050, this group will be around two billion people.
The most rapid increase in the 60+ population is occurring in the developing world. It is expected to show a 225% jump between 2010 and 2050.
In our youth, the issue of aging wasnt something we lost sleepover. Our energy levels could withstand anything. We woke up feeling fresh and ready to take on the day. We even indulged in a double-cheese pizza didnt result in our picking up a very resistant 3kg, seemingly overnight.
However, over time, the reality of aging kicks in. Now, science reveals that our lifespan will be determined 70% by our lifestyle and 30% by genetics.
Scientists such as Australian-born David Sinclair, a leading researcher in the field of aging at Harvard Medical School in the US, believes youthfulness can also be reset in the body, using epigenetic reprogramming. He says: Soon we will be able to tweak cells in a particular way that the central nervous system behaves as if it were young again. This is an exciting moment in time for the science of longevity. Researchers are on the verge of understanding the process of aging and how to create drugs that promote extended healthy longevity.
Lifespan refers to how long a person lives, from birth to death. Healthspan, on the other hand, is about how many of those years were lived in complete health. It describes how long we are able to function without the assistance of others, in the absence of chronic disease and frailty.
Dr. Craige Golding, a specialist physician and pioneer of aging medicine in South Africa explains: I always say to my patients, if theyre going to get older, they not only want the absence of diseases like cancer, dementia, Alzheimers, but they also want to have good mobility, good vision, and good memory. [Integrative medicine is about] incorporating many modalities, not just fighting to age. Its about looking at the person holistically, not just treating a diagnosis.
More often than not, a patient is labeled with a diagnosis, given a bunch of pharmaceuticals, and sent home. However, in holistic or integrative medicine, we look at the person as a whole. How is their diet? How is their lifestyle? Are they exercising? Are they sleeping well and managing their stress levels? What supplements are they taking? With lifestyle and supplement changes, one can often reverse these kinds of chronic conditions. Thats where my passion grew for integrative medicine because as a physician in private practice, I realized that I wasnt helping my patients with chronic diseases enough.
There are so many associated diseases when it comes to aging, he explains. When you combat these mechanisms and understand them, you can prevent many diseases.
Like Sinclair, Golding believes that by positively engaging with your health and beauty, incorporating time-honored and science-based wellness practices, and understanding how to combat aging with these practices, you can actively lengthen and improve your healthspan, and influence how you age.
Aging is a series of multiple processes. These processes include:
These processes result in the familiar signs of aging and ultimately to the development of age-related diseases that eventually kill us.
Combining analysis of cutting-edge scientific findings with our deepest ancestral wisdom and health-promoting practices, we can help to prevent and manage the most common health afflictions of our day: cancer, heart disease, neurodegenerative diseases, and metabolic syndrome. That way, if youre serious about really living well for long, you figure out which areas of your health need attention and how to work on those.
Today there are many tests that can be done to determine how healthy you really are and what lifestyle changes or supplements will make a difference. You have the option of assessing your hormones, seeing where you are in terms of stress levels, as well as testing your nutrigenomics, inflammation markers, glycation markers, detox markers, telomere markers, and methylation markers.
However, this can be a costly exercise, and deciding where to focus your attention can be tricky.
The easiest way to start is to look at the 10 primary mechanisms of aging and discuss your aging concerns, and the areas that need to be looked at, with your doctor. This will help you determine what can be done to intervene against these mechanisms.
Oxidative stress occurs when there is an imbalance of free radicals and antioxidants in the body. Examples of free radicals include hydroxyl radical, nitric oxide radical, and superoxide. This can be countered with good-quality antioxidants in the diet and supplements, as well as specific lifestyle changes.
Glycation takes place between reduced sugar and proteins, lipids and nucleic acids, wherein reactive carbonyl groups of a reducing sugar react with free amino groups of proteins to form an unstable Schiff base. Advanced glycation end products are formed through this reaction.
Telomeres are the caps at the end of chromosomes that protect the cells. These wear down as you age until they are so short that they cant protect your cells.
Golding explains that, in his practice, there is a test called a telomere link or teloyears. The longer the link, the younger you are biologically and the longer you will probably live.
So lets say youre 60 years old. Youre significantly overweight. You have early signs of Type-2 diabetes. Youre eating poorly, youre not exercising, and youre stressed out. Generally, in that scenario, your telomere length is going to be very short. This means your lifespan is probably going to be shortened significantly. Once your telomeres disappear, your cells can no longer divide. You enter a state called cellular kinesthesis, where you cant replicate your cells anymore. Thats one marker of what you can do to know your telomere length, and with lifestyle interventions such as proper diet, taking good supplements, sleep, exercise, and managing your stress, you can actually extend your telomere length, whatever your age. Your hormones, genes, social interactions all of these things play a role, and the lifestyle components are very important.
Astragalus membranaceus (AST) is a plant-based compound that demonstrates, in labs, immunomodulatory, antioxidative stress and anti-aging effects which are associated with extending longer telomeres, thus extending lifespan.
By the time one is middle-aged, levels of NAD+ (nicotinamide adenine dinucleotide) have fallen to 50%, with resulting loss of sirtuin and PARP activity.
PARP inhibitors are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP). They are developed for multiple indications, including the treatment of heritable cancers. Sirtuins are a family of histone deacetylases that seem to regulate oxidative stress and damage to DNA, as well as organismal lifespan. Compelling research shows that NAD+ has a unique ability to protect tissues, induce DNA repair, and increase lifespan. It has long been known that NAD+ plays an important role in transferring energy released from glucose and fatty acids to the mitochondria, so that it can be converted into cellular energy.
Recent studies have revealed that the decline in NAD+ levels causes aging-related disorders, and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models.
Nicotinamide mononucleotide (NMN) has been shown to mitigate many aging-related dysfunctions.
Senescent cell production occurs throughout life and plays beneficial roles in a variety of physiological and pathological processes. This includes embryogenesis, wound healing, host immunity, and tumor suppression.
Meanwhile, throughout life, the steady accumulation of senescent cells in the body with age also has an adverse consequence that leads to age-related death. Senescent cells dont divide or support the tissues of which they are part. Instead, they emit a range of potentially harmful chemical signals that encourage nearby cells to enter into the same senescent state.
Autophagy (the natural process in the body of removing damaged cells, and thereby regenerating newer ones) was originally thought to suppress cellular senescence by removing damaged macromolecules or organelles. Now, recent studies also indicate that autophagy promotes cellular senescence by facilitating the synthesis of senescence-associated secretory proteins. As a result, a different strategy to remove the accumulation of senescent cells is needed.
A new class of drugs, known as senolytics, focuses on the destruction of these stubborn death-resistant cells from the body to reduce inflammation and improve tissue function.
While scientists are looking for more powerful synthetic drugs, Golding incorporates two of the most powerful natural senolytics in his senescent cell removal program. These are fisetin and quercetin. Fisetin is a plant flavonoid found in fruits, mostly in strawberries. Quercetin is a flavonol pigment found in fruits and vegetables, with its highest concentration found in capers. It has antioxidant properties that work to protect the body from free radicals and oxidative stress and is considered to be a more powerful antioxidant than vitamin C, vitamin E or beta carotene.
Resveratrol is an everyday maintenance program against senescent cells. Its a known activator of SIRT1, which slows aging, and has been demonstrated to inhibit mTOR activity and cellular senescence.
Mammalian target of rapamycin (mTOR) is a signaling pathway heavily linked to the aging process.mTOR is stimulated by nutrients and growth factors, and inhibited by stress, to ensure that cells grow only during favorable conditions.
As with most healthspan-related advice, caloric restriction is advised. Fasting and a reduction of calorie intake is implicated with mTOR inhibition. The two most popular options are a small feeding window (four hours per day) or 24-hour fasts two to three times per week.
The SIRT1 gene is a multifunctional protein deacetylase that plays important roles in cellular pathways including longevity, metabolism, cellular senescence, genome maintenance, DNA repair, and inflammation. Thus, the loss of NAD+ has direct and indirect consequences on multiple cellular endpoints. Ultimately, depletion of intracellular NAD+ alters the NAD+/SIRT1 axis and leads to defects in mitochondrial homeostasis, ROS production, DNA repair, and cell survival.
It has consistently been shown that the loss of activity from the NAD+/SIRT1 axis also inhibits mitophagy (the selective degradation of mitochondria by autophagy).
Nicotinamide mononucleotide (NMN) and NR, a key NAD+ precursor intermediate which decreases with age in mammals, is an efficient therapy against age-associated diseases. Research has further demonstrated that NMN activates Sirtuin1 (SIRT1), which is a NAD enhancer.
Proteostasis is the concept that there are competing and integrated biological pathways within cells that control the biogenesis, folding, trafficking, and degradation of proteins present within and outside the cell. One of the results of a loss of NAD+ as a person gets older is a loss of proteostasis, causing havoc on the system.
Once again, NMN and/or NR is an efficient therapy against age-associated diseases, including loss of proteostasis.
Inflammation drives all diseases, and it can ignite a long list of disorders. This can includearthritis, asthma, atherosclerosis, blindness, cancer, diabetes, and, quite possibly, autism and mental illness.
In clinical practice, we can do a simple test, called a C-reactive protein, on the blood, says Golding. Then we can intervene with simple supplements, such as curcumin.
This causes cancers, senescent cells and tumors, and accelerates aging. mTOR is the master anabolic regulator that organizes many other nutrient sensors, such as insulin, leptin and insulin-like growth factor (IGF-1), a hormone that supports growth development, healing, muscle-building and bone strengthening, depending on what the body needs.
Because mTOR is stimulated by insulin, growth factors, blood factors, phosphatidic acids and oxidative processes, when we eat, its best to avoid animal proteins and lots of processed sugars.
Dietary additions such as resveratrol and metformin have been shown to inhibit mTOR upstream. Metformin isnt available in stores, so ask your medical doctor for a prescription. Dont forget that resveratrol should betransandwhitein color.
Rapamycin supplementation has also shown promise with mTOR, but due to the serious side-effects, its not recommended.
This results in sarcopenia, loss of skeletal muscle mass and strength. It can also lead to catabolism of lean tissue and muscle disorders. This can accelerate premature aging and make you prone to other metabolic diseases. Because the body and all the cells consist of protein, which requires the presence of anabolic precursors and building blocks, you need mTOR and amino acids for existence and DNA repair.
Note: This article was co-authored with Longevity health writer Johane Du Toit and first appeared in Longevity magazine.
New research suggests that there may be a way to not only prevent premature aging, but possibly reverse it. In fact, for the first time ever, a human study has shown a reversal in the biology of aging, with hyperbaric oxygen therapy (HBOT).
Global longevity and anti-senescence therapy market || keyplayer Senex Biotechnology, and Senolytic Therapeutics – FLA News
The factors responsible for the development of this market are increasing emphasis on stem cell research, increasing demand for cell-based assays in research and development, and increasing geriatric population across the globe.
The globallongevity and anti-senescence therapymarket accounted for US$ 361.6 Million in 2019 and is estimated to be US$ 1397.1 Million by 2029 and is anticipated to register a CAGR of 14.5%. The reportGlobal Longevity and Anti-senescence Therapy Market,By Therapy (Senolytic Drug Therapy, Gene Therapy, Immunotherapy, and Others), By Application (Longevity, Senescence Inhibition, Cardiovascular Diseases, Neural Degenerative Diseases, Ophthalmology Disorders, and Others),andBy Region (North America, Europe, Asia Pacific, Latin America, and Middle East & Africa) Trends, Analysis and Forecast till 2030.
Growing geriatric population globally
Geriatric population of world continues to grow at an unprecedented rate. According to data published in An Aging World: 2015, the percentage of aging population is expected to jump to nearly 17% of the worlds population by 2050 (1.6 billion). Further, as per the data reported by National Institutes of Health, Americas 65-and-over population is estimated to almost double over the next three decades, from 48 million to 88 million by 2050. The global population of the people aged 80 and older is projected to increase at triple rate between 2015 and 2050, rising from 126.5 million to 446.6 million. The population in countries like Asia and Latin America is projected to quadruple by 2050.
Increasing awareness regarding Antiaging Products among Generation Y and Later Generations
Anti-wrinkle products have formulation well matched to slower the aging process and thus are gaining traction globally. Major causes of wrinkles involves lack of essential nutrients in the body, exposure to UV light and pollution for higher duration, dehydration, smoking, and drugs, along with other genetic factors. Higher importance of appearance and greater aging anxiety are related to greater likelihood of purchasing anti-aging products.
Additionally, rising advancements in anti-senescence technologies and surging level of disposable income are also gaining traction in the target market. Furthermore, surging demand for cell-based assays in research and development and growing prominence on stem cell research is likely to gain significant impetus for the longevity and anti-senescence therapy market share over the forecast period.
Browse 60 market data tables* and 35figures* through 140 slides and in-depth TOC on GlobalLongevity and Anti-senescence TherapyMarket, By Therapy (Senolytic Drug Therapy, Gene Therapy, Immunotherapy, and Others), By Application (Longevity, Senescence Inhibition, Cardiovascular Diseases, Neural Degenerative Diseases, Ophthalmology Disorders, and Others), andBy Region (North America, Europe, Asia Pacific, Latin America, and Middle East & Africa) Trends, Analysis and Forecast till 2030
Key Market Insights from the report:
The globallongevity and anti-senescence therapymarket accounted for US$ 165.6 Million in 2019 and is estimated to be 857.7 Million by 2029 and is anticipated to register a CAGR of 17.7%. The market report has been segmented on the basis oftherapy, application, and region.
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The prominent player operating in the global longevity and anti-senescence therapy market includesAcorda Therapeutics, Human Longevity Inc., Calico Life Sciences, Insilico Medicine, Oisin Biotechnology, Recursion Pharmaceuticals, Restorbio, Proteostasis Therapeutics Inc., Senex Biotechnology, and Senolytic Therapeutics
The market provides detailed information regarding industrial base, productivity, strengths, manufacturers, and recent trends which will help companies enlarge the businesses and promote financial growth. Furthermore, the report exhibits dynamic factors including segments, sub-segments, regional marketplaces, competition, dominant key players, and market forecasts. In addition, the market includes recent collaborations, mergers, acquisitions, and partnerships along with regulatory framework across different regions impacting the market trajectory. Recent technological advances and innovations influencing the global market are included into the report.
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Mental illness seems to be on the rise in modern society. A vital strategy for maintaining a balanced mood, good energy levels, and sound brain connection is to be aware, to be present, and to be open to new ideas, behaviors, and perceptions.
While genetic predisposition certainly increases our risk for mental illness, the following wellness practices can dramatically reduce it:
According to specialist physician and pioneer of aging medicineDr. Craige Golding, there are well-researched alternatives to the overprescribing of chemical drugs to manage mental illness. Micronutrient depletions from the chronic use of pharmaceuticals should also be addressed. An understanding of the major neurotransmitters involved with mood, memory, motivation, sleep and a balanced, healthy mind is required.
The COVID-19 pandemic has highlighted the need for stronger immune systems. We all know that sunlight exposure, vitamin D, and vitamin C are very beneficial for optimum immune system health. Other useful nutrients include zinc and ionophore-type nutrients to get zinc intracellularly, to assist with optimum antiviral protection. These include nutraceuticals such as quercetin and/or egcg (a green tea extract), and resveratrol.
Medicinal mushrooms such as reishi, maitake, and shiitake are also useful for immune support.
Of course, there are many other immune-supportive strategies to consider. This includes exercise and a healthy, balanced diet with a wide variety of colorful foods.
For a healthy immune response against a viral attack, other treatments include:
These help the heat-sensitive viruses become more vulnerable and susceptible.
Golding stresses the importance of good gut function because conditions such as leaky gut or hyperpermeable gut can interfere with the absorption of nutrients. He advises following a five-step program:
Temperature fluctuations place a type of stress on the body that can be helpful. Having a cold shower and then an infrared sauna can be beneficial for physiological adaptation. The idea behind this is that the better you are able to adapt to your conditions, the better your chances of living longer. This relates to your mental resilience and your immune system.
Several kinds of adaptogenic herbs are used to help your adrenals in alternative medicine. Astroganda, for example, originates from certain mountainous plants that regularly experience severe fluctuations in temperature. They have learned to adapt and survive in hot-to-cold conditions.
Golding says caloric restriction, intermittent fasting, and time-restricted eating are all important pro-aging strategies.
The fear of a second wave is impacting how were looking forward to 2021. With that said, here is some advice on how to cope and manage your fears during the second wave.
Global Folding Carton in Healthcare Market (2020 to 2025) – Growth, Trends and Forecasts – ResearchAndMarkets.com – Business Wire
DUBLIN--(BUSINESS WIRE)--The "Folding Carton in Healthcare Market - Growth, Trends, Forecasts (2020 - 2025)" report has been added to ResearchAndMarkets.com's offering.
The Folding carton market for the Healthcare market is expected to register a CAGR of 5.72% during this forecast period.
Key Market Trends
Growing Emphasis of Monitoring and Assisting Patient Medication
Asia Pacific is the Fastest Growing Region for this Market
Key Topics Covered:
2 RESEARCH METHODOLOGY
3 EXECUTIVE SUMMARY
4 MARKET DYNAMICS
4.1 Market Overview
4.2 Market Drivers
4.2.1 Stringent regulations related to discerning key product related information in the field of medical devices?
4.2.2 Growing emphasis of monitoring & assisting patient medication ?
4.2.3 Focus on traceability & anti-counterfeiting in the healthcare sector
4.2.4 Product & Material-based innovations driven by major packaging manufacturers to drive demand
4.3 Market Challenges
4.4 Market Opportunities
4.5 Key material properties of Folding carton-based secondary packaging materials
4.6 Analysis of the impact of COVID-19 on the Folding Carton in Healthcare industry
5 KEY PRODUCT INNOVATION IN FOLDING CARTON INDUSTRY
6 MAJOR INNOVATIONS IN LEAFLET & INSERT PACKAGING FOR HEALTHCARE
7 MARKET SEGMENTATION
7.1 Product Type
7.1.2 Vials & Ampoules
7.1.4 Other Product Types (Medical Devices, etc)
7.2.1 Labelling Type?
220.127.116.11 Pressure Sensitive
18.104.22.168 In-Mold ?
22.214.171.124 Others (Custom Die-cut, etc.)
7.2.2 Advancements in the Labelling Industry (to include coverage on the growing adoption of digital printing & Flexography Printing)
7.2.3 Key regulations on Medical Device Labelling (FDA, IMRDF, etc.)
7.2.4 Key specific manufacturers in Labelling
126.96.36.199 WS Packaging
188.8.131.52 Schreiner Group
184.108.40.206 Faubel & Co
220.127.116.11 OPM Group
7.3.1 North America
7.3.4 Rest of the World
8 COMPETITIVE LANDSCAPE
8.1 COMPANY PROFILES
9 MARKET OPPORTUNITIES AND FUTURE TRENDS
For more information about this report visit https://www.researchandmarkets.com/r/yahj24