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2016 Reminder Healthy Living Can Add Up To 14 Years to Your Life

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The Ethics of the Future: Human Genetic Engineering and Human Immortality Medicine is Coming in 19 years!!

Posted: January 1, 2015 at 12:46 pm

The Ethics of the Future: Genetic Engineering and Immortality Medicine

2015 is Going to Be a Fascinating Year for Longevity Science

By Professor Mark

How do you feel about the potential for great advances in Human Longevity Science that have been occurring in recent years? Do you feel excited about the prospect of living a much longer life, or are you indifferent? Are you nervous about the prospects of what this sort of tinkering with genetics and human nature might bring?

Is the potential for a vastly expanded lifespan going to be something that everyone can enjoy, or will it be an advantage simply for those that can afford it? If you could live 100 years longer, would you want to? Would you care if the opportunity were afforded to you as an individual? Would such a huge opportunity lead to a new and beautiful life on earth, or would earth somehow take these momentous advantages and turn the world on its head?

My Beliefs Regarding Advanced Genetic Engineering

Many years ago, when I was an undergraduate at Penn State, our professor posited similar questions in our Genetics Class, which played a major role in affecting my beliefs toward the subject of hyper-longevity and Genetic Engineering. The class was large, with more than 100 students, and my professor asked the class what their opinions were regarding the use of genetic manipulation and engineering to alter human life.

Surprisingly, the class was completely silent. In response to this silence, the professor called up two students to debate the subject. One of my classmates volunteered to voice his opposition to genetic engineering, and I chose to volunteer, providing an argument in favor of it.

My opponent voiced his opinion to the class that genetic engineering for this purpose would be ethically wrong because it is not in man’s best interest to play God. Most of our classmates seemed to agree, nodding subtly in agreement.

Personal Aesthetic: Choosing to Be Different

I felt as though I was standing upon a grand crossroads of history. As I looked around the class, it felt as though all of my classmates, for all of their cliquish differences, were being incredibly closed-minded, like they just accepted what they had been told all their lives and were afraid to think for themselves.

After the professor gauged the response of the students, I had my opportunity to argue in favor of this advanced human genetic engineering. I glanced around the class, and felt my argument come together cleanly in my mind. I saw white girls with bleached hair stretching down their backs, more than a few of which had fake breasts. I saw black girls with expensive weaves and complex and expensive hairstyles.

There were white students mimicking their hip hop and rap idols, and I even saw a young Asian student that had very obviously dyed her hair red. In my class I saw a great commingling of different styles. People both attempting to exemplify American standards of beauty and those taking on the aspects of other cultures, adopting them as their own.

As I looked around at all of this, recognizing the great diversity in my class, I had a strong feeling that there was not one person in the class that didn’t have at least one thing they wanted to alter about the characteristics they were born with. I continued thinking to myself, that these students probably wanted to be different in a variety of different ways: some wanted to be smarter, some taller. Some girls wish they had larger breasts, and some guys wanted larger penises. Others probably wish that they didn’t have to go through the trouble to put in contacts and hair dyes to look like the person they wish they were. For myself, I would have given anything just to be a few inches taller.

A Call for Genetic Freedom

After standing quietly for a moment, with all of these thoughts running through my at head a rapid place, I spoke from my position, in the back of the class, and suddenly stated loudly: Genetic Freedom!

I felt that just those two words spoke for themselves, but my professor threw a dejected glance in my direction, and I could detect her shaking her head almost imperceptibly. Her silence was a sign that she needed more. After the brief silence, I continued. I argued to the class that the individual should have full control to alter his DNA as he sees fit, so long as it doesn’t negatively impact society or the rights of anyone else.

She seemed thoroughly unhappy with the argument, and the class began to chatter loudly, nearly in unison. After the short spate of controlled chaos, the class continued with liveliness and energy, but I felt that others in the class largely shunned me as a result of the fervent beliefs I expressed in regard to what legitimately amounted to the potential future of the human race.

Will People Be Able to Resist Genetic Alteration?

I still laugh to myself to this day about how my belief met such incredulity in the face of so many. In the future, once science makes it possible to make such powerful changes to humanity at the genetic level, I am confident that these same students, if given the actual opportunity to improve themselves through futuristic genetic methods, would absolutely jump at the chance with no second thought.

It wouldn’t be Playing God. It wouldn’t be unethical. It would simply be the new reality. In fact, once the time comes to pass when Genetic Alteration becomes a reality, the exact same people today that seek out plastic surgery and cosmetic surgery will clamor for these procedures as soon as they become available. In the end, I believe I made a B in the course, which is regretful, because I’ve always remained highly interested in genetics.

The Future of Humanity: The Organic and the Engineered

Another of my professors at Penn State, himself with a doctorate in genetics, explained an interesting aspect of human evolution, one which I had never thought of before. He explained that the many races that make up humanity as a whole developed their differences as a result of dispersing far from one another, and slowly adapting to their new environments over time.

After they migrated, geography, distance, and other factors kept them from interacting heavily with one another, which caused their minor adaptations to become more pronounced. In the same way that they developed their own habits and cultures, their aesthetic and physical makeup also changed. Some grew taller, others grew paler, and each individual culture became maximally resistant to the diseases which were prominent in their area.

Even though these physical and genetic changes were significant, any healthy woman on earth could still mate with any other healthy man, no matter how different he looked or acted. What he said that truly sparked my mind was that if the different races of human beings stayed geographically isolated from one another for longer period of time, eventually the different races could have changed enough to where they could no longer produce children with one another.

Could Genetically Engineered Humans Evolve Beyond Humanity?

This can also apply to the future of genetic engineering. The modern world is so interconnected that geography has no impact on the ability of humans to breed with one another, but genetic enhancement may lead to a point at which a human born today would not be able to mate with an individual that was the result of generations of genetically altered parents.

As Genetic Engineering becomes more advanced, humans may change enough at the genetic level to prevent interbreeding between lineages which have undergone these advancements and those that chose not to. This change would of course be gradual, first reducing the ability to conceive before denying that ability altogether. At this point, it would take genetic engineering just to create a viable child for two disparate humans. Interestingly enough, it may even come to pass that different species of humans evolve from such endeavors, as distinct from one another as they are from humans themselves.

The beginning of this story could begin sometime in the next hundred years, as scientists and medical specialists develop the ability to safely and effectively alter DNA to meet the specifications of the individual.

The Future is Coming: the Great Human Divergence and the Neo-Sapient

The people that choose to reject Genetic Modification and Advanced Longevity Treatments in the near future will create an interesting binary world. This could be the beginning of a grand human experiment. This could be the focal point of a genetic divergence so strong that it literally fragments the human race, creating a new class of post-humans that have advanced to a point where they qualify as their own unique species.

I think back to the genetics course I mentioned earlier. I remember the absolute ocean of diversity that was contained within the 100-student course, and I was able to visualize a future in which Genetic Modification leads to even greater diversity, and a uniqueness that has never existed in the history of the human race. It made me think of the diversity of the universe, and the unlimited options for diversity that it represents. As someone with an affinity for astronomy, I find it utterly inconceivable that planet earth is home to the only lifeforms in the universe.

Of course, along with my great optimism, I do recognize that there are risks and unknowns related to the future of Genetic Modification. There is even the potential that the science behind Genetic Modification could be used for Genetic Warfare. There is certainly the potential that the same science that creates a new humanity could be used to destroy large swathes of it. I can imagine an apocalypse that is not nuclear and grandiose, but genetic and nanoscopic.

Post-Humanism and the Search For Other Worlds

In the end, will humans be able to develop interplanetary travel and colonization in order to insure itself against such potential apocalyptic scenarios? It’s a subject that I am particularly concerned with, and is the core reason why I support NASA and the United States Space Program. As the world moves faster and the dangers become greater, it is imperative that we are able to save humanity even in the case of a state of mutually assured destruction.

If there truly is a Genetic Revolution on the horizon, it is vitally important that we use all of the resources we have available in order to make our dreams of space colonization a reality. Imagine a future so spectacular: A future where a multitude of post-human species advance outward from earth in order to colonize space like a rainbow across the galaxy.

This journey will be arduous and epic, as earthlings spread across the cosmos in order to find new viable homes and potentially interact with other life forms.

What Would Aliens Be Like?

Can you imagine how literally otherworldly that would be? If we found advanced aliens, would they have unlocked the key to eternity? Would we have done the same? There is no doubt that the first time that we make contact with an extraterrestrial species, they will come from worlds and cultures which are absolutely unimaginable in the face of everything that we have experienced.

I may have delved a bit into the realm of science fiction, but the future of humanity in the face of Genetic Modification has the potential to be every bit as exciting and otherworldly as the potential future that I just described. It instills a tremendous sense of fear, awe, and most importantly, unlimited potential.

Do You Think That You Could Handle Immortality?

If you ask the average person out on the street about the potential future afforded by Genetic Engineering, Advanced Longevity, and Immortality medicine, you’ll likely get a number of different responses, some positive, some negative, others simply incredulous. If you surveyed 100 people, I believe that you would find that the majority would ultimately reject the idea of immortality.

Some people think that eternity would take the excitement out of life. Others fear that they would eventually just become a broken shell of their former selves as their bodies physically decline in spite of science’s ability to prevent death. For many, the concept of eternity is just as fearsome as the concept of death itself. It’s not all that different from the way that people feel about retirement these days. They are frustrated because they have to work so hard all through the healthiest part of their lives only to be too frail and broken down by the time they retire to enjoy it.

Longevity Medicine and the Future

That’s why Longevity Medicine is so important. We want our retirement years to last as long as possible, and we want to be able to enjoy them. Maybe one day, we will be retired as long in our lives as we are at work, or longer! That’s what the approach to immortality will be like!

There are a growing number of people that are optimistic about a lengthy future. They understand that even with regard to a concept like immortality, life is the sum of individual experience. Some will take advantage of a life bordering on immortality, while others would simply choose to be boring. People that live lives full of happiness and vitality shouldn’t be deprived the opportunity to extend that joy, simply because there are others who wouldn’t appreciate it!

The arguments stemming from the subject of Human Immortality continue to become both more interesting and more complex, both for those that long for such a fate, and those that oppose the concept. No matter how you feel about the idea of Advanced Longevity, there is no doubt that such opportunities to live lives we now consider unimaginable will eventually come to pass.

As long as human beings are able to engage in scientific advancement without destroying ourselves or sending ourselves back to the stone age, such opportunities will present themselves to the human race in the near future.

Gene Therapy and Stem Cell Therapy: The First Steps to Hyperlongevity

The seeds of these future endeavors are being planted today, in the fields of gene therapy, genetic medicine, and stem cell therapy. This is also the core concept behind medical treatments which seek to optimize hormone production in the body in order to alleviate the medical conditions associated with hormone imbalance and aging.

Hormone Replacement Therapy: Streamline Your Body for the Future!

Treatments such as Testosterone Replacement Therapy, Sermorelin Acetate Therapy, and Bio-Identical Human Growth Hormone Replacement Therapy seek to correct common hormonal imbalances that occur as a result of the aging process. There is even a strong argument that these hormone imbalances are actually the root cause of many symptoms of aging, including frailty, osteoporosis, and cognitive decline.

There are many Health, Wellness, and Longevity Physicians that believe that these forms of Hormone Replacement Therapy are some of the must effective means to prolong a healthy and active life when used in combination with a healthy and conscientious lifestyle. These medical treatments are the best way to decrease your mortality risk so that you are more likely to experience the next great advancement in Anti-Aging Medicine.

If you feel that your quality of life has been on the decline as a result of changes in your body and mind resulting from the aging process, I strongly encourage you to get your hormone levels checked, because there is a significant chance that you may be suffering from a reversible form of hormone deficiency.

The Future of Human Genetic Engineering

This is truly an exciting time to be alive. We are quickly approaching the point at which scientific breakthroughs in health science will continue to occur at an ever-increasing pace, with groundbreaking new health advances occurring on a regular basis. The following years will be incredibly interesting, because there are a multitude of clinical trials regarding the promise and potential effectiveness of both gene therapy and stem cell therapy.

By 2012, these studies, and other similar studies, were already displaying high levels of potential to both treat and protect both animals and humans from disease. Beyond Hormone Optimization and Genetic Therapy, the next stage of advancement will most likely be in the field of nanomedicine. Beyond nanomedicine is femtomedicine.

At this stage of scientific inquiry, this is as far as even the most forward-thinking physician or philosopher could imagine, but there is no doubt as we create new medical treatments and expend our knowledge of medical science, new opportunities for advancement will be conceptualized that could be even more life-altering and fantastic than those that we just mentioned.

When you consider the future of medicine and longevity, you realize that human beings as they are now aren’t simply the end result of millions of years of evolution, but also a gateway to the next state of terrestrial life, a transitional state between what was and what will be, an opportunity to experience even greater consciousness and enlightenment by conquering time, itself.

What is the Idea Behind Human Immortality?

When we discuss the idea of human immortality, it doesn’t just mean allowing a human being to live forever, human immortality represents the idea that it will be possible, with future biomedical and genetic enhancements, for human beings to experience a practical immortality in which one is able to live as they were in the prime of their life, for all of their life.

It seems just as you master your body and your mind in the late twenties and early thirties, your body and mind start to enter a slow and unstoppable decline. What if you could preserve that period of physical and psychological perfection forever? It is during this period that the average person reaches his or her functional peak as an individual, with regard to strength, cognitive ability, immunity, and overall health.

How Much Better Would Life Be if You Lived to 200?

Think about how different and exciting that life would be if you could have the body and mind of a 29 year old for 120 years. There are a number of people that think that humans should not have this opportunity, but it sounds much better than spending the whole sum of those years in slow and steady decline.

How Much Better Would Life Be if You Could Live Indefinitely?

Immortalists subscribe to the belief that individuals that truly enjoy life and are creative or passionate enough to find interesting or fulfilling things to do would be able to easily take advantage of a significantly lengthened lifespan. I do understand how such a long life would feel to someone that lacks passion or imagination, however. I can imagine two hundred years of absolutely drudgery. If one does not have the propensity to invest or save to create wealth, I can imagine two hundred years of hard work with nothing to show for it.

With luck, a more automated world would allow us to enjoy our lives while actually working less. Imagine a world of eco-friendly machines could do the work of one hundred men. This could be a wonderful world of leisure for all, but it could also lead to a world where machines are used as a method of control and domination, like in Frank Herbert’s dystopian novel Dune.

The Temptation of Human Immortality

Whether the opportunity for Human Immortality comes in twenty years or two hundred years, there will be those that seek out the opportunity for such a life, and there will be those that choose to reject the opportunity for immortality.

The central question that Immortalists posit is a simple one: Why would anyone actually want to die or grow old? When you think of it that way, it sounds absolutely silly. Who would ever want to do such things? But in reality, it seems as though most human beings are resigned to such a fate.

Who Really Wants to Grow Old?

More than simply growing old, who wants to lose their lust for life or their libido? Who wants to experience their own body slowly deteriorate as they are beaten down by illness and disease? Human Immortalists are those that are willing to fight against what is perceived as inevitable by society at large. They believe that those that have resigned themselves to decay and death are simply not willing to imagine a post-human age where they could evolve beyond the inevitability of death.

It seems that many humans think of Human Immortalists as harbingers of doom which are going to bring about a new genocide. They believe that Immortalists are going against the will of God by altering the Human Genetic Code in an attempt to foster extreme lifespans, improved aesthetic, and vastly improved health outcomes.

The Great Schism of Humanity

There is a strong chance that a rift will develop between those that choose genetic alteration and those that choose to forgo such opportunities. In the end, it is likely that humanity will rift into two distinct groups. Over time, greater and greater numbers will opt for Genetic Modification, and those that opt out of such procedures may potentially lose footing in society as a result of their choice.

If modification indeed has the ability to create such disparity, genetically modified humans will spread their genes with one another, and their offspring may have greater potential for both prosperity and intellect, which will create a socioeconomic rift between GM Humans and Unmodified Humans.

Will Post-Humans be able to act ethically under these circumstances? Will Unmodified Humans be able to accept a place in the world where they are unequivocally inferior to their GM counterparts? This new world will be different and exciting, and it’s up to us to create a civil world where we can act in the best interest of all.

What Other Strange Opportunities May Become Available in the Future?

On top of our ability to vastly extend and improve our long-term health, the future will also provide us with enhanced opportunities with regard to personal aesthetic. We will not only be able to cure conditions such as psoriasis which plague millions in the world today, but many may choose to move beyond mere optimization and may choose to fully customize their appearance. Perhaps one may choose not to have olive or alabaster skin as many in society desire today, but go for a different color all together.

What if someone chose to color their skin orange, green, or blue? What if they wanted to be leopard print or covered in zebra stripes? This may appear otherworldly and unnatural to our minds, but when presented with an entire array of customization, what would be so strange about doing something like that to stand out? How different would it be to dying your hair blue or rainbow, if there were no dangers in undergoing such a change?

But, given enough time and scientific innovation, skin color and other basic augmentations like genetic breast and penis enlargement will be just another evolution in the concept of general aesthetic. The potential for more extreme changes would eventually become possible. What if humans wanted to take on the characteristics of animals? What if someone wanted the ears or tail of a cat, for example? There would even be the potential to do even more drastic things that we can barely imagine today.

Genetically Engineered Pets

These genetic advancements won’t occur in a human vacuum. They will also apply to animals as well. Today people are paying top dollar for basic genetically modified hypo-allergenic dogs, and glow-in-the-dark mammals have even been developed in laboratories.

In the future, it is likely that scientists will come up with scientific modifications which significantly enhance both the aesthetic and intelligence of animals. It’s even likely that animals will experience the benefits of genetic engineering more quickly than humans, as this future will largely be facilitated by means of animal testing.

The Post-Human Era Starts with Basic Genetic Engineering and Ends with Post-Humanism, Hyperlongevity, and Potential Immortality

You may not be able to tell, but we are already in the midst of the first phase of the Post-Human era. The beginning of this era was marked by the first time that egg and sperm from two different individuals was combined and implanted into an adoptive mother. It was such a grand event in retrospect, but the passing into this new era was not met with massive celebrations, but simply with concerns over the ethics of the new future.

Post-Humanity will have a litany of moral conundrums to unravel, some that we can imagine, and others that are unfathomable to us today. The state of the mortal mind is simply not equipped to handle the moral and ethical quandaries that the genetically modified mind will face. What if there are other lifeforms just like us in other parts of the galaxy, that have also learned to take control of their very existence on the cellular level? What if the number of unique alien civilizations in the universe is unlimited? What if we as earthlings are just one form of intelligent life among a countless litany of others?

The Current State of Genetic Modification and Gene Therapy

Today, scientists, researchers, and physicians are taking the first step into this future, with the quickly growing field of genetic therapy. We are on the cusp of doing some truly amazing things, like genetically altering viruses in order to protect humans from genetic disorders and conditions. At first, these initial treatments have been risky, reserved for those in most dire need, but as medical science becomes more well-versed in these therapeutic advancements, they will become safer and more widely available to the general public. Could you imagine reducing your risk of cancer by 80% just with a single injection? That may be the future for you.

The Current State of Organ Regeneration and Stem Cell Therapy

Another aspect of genetic therapy has to do with the advancing field of Stem Cell Therapy. There are new, state of the art treatments available which utilize stem cells in order to improve the health of the heart. Patients that have experienced heart attack or heart disease can be treated with stem cells which have the ability to develop into new and healthy muscle tissue.

Similar techniques have also been used in order to regenerate other parts of the body or parts of individual organs. In one famous case, scientists biomanufactured a windpipe for a patient with the patient’s own cells. They were able to do this by taking the stem cells and allowing them to grow in culture before pouring them over a scaffold in the shape of a windpipe. Just by providing the cells with the nutrients to grow, they were able to recreate a human windpipe in the laboratory just in a matter of days.

Because the windpipe was created from the patient’s own cells, the body did not reject the windpipe when it was surgically implanted into the body. This is one of the first successful cases where a patient’s life was changed through the scientific advancements of genetic organ replacement.

Stem Cell Therapy Will Be Available in the Near Future: Hormone Replacement Therapy is Here Today!

Stem Cell Therapy is exciting and will become increasingly common and popular over the next century in the United States. Today, there are a few places where Stem Cell Therapy is available internationally, especially in Asia, but they have yet to be medically certified, and there are still a number of pertinent risks involved. In the Western World, Stem Cell Treatments are currently going through clinical trials. Although the results are mixed, continual progress is being made.

There are many scientists that believe that Stem Cell Research will lead to a new future in medicine, but policies enacted during the presidency of George W. Bush have set the United States behind by at least a decade, and other nations in Europe and Asia are currently taking advantage of their head start, and may one day eclipse us in these new and futuristic medical therapies.

In just a few short years, genetic testing will become affordable enough that it will become a common and recommended part of prenatal care as well as regular checkups throughout the lifespan. Over time, more and more Genetic Disorders will be able to be effectively treated with Gene Therapy, and with every breakthrough, people will be that much more likely to live a longer and healthier life.

Once the clinical science is sound, it won’t even be a difficult ordeal for the patient. It would simply be like going to visit the pharmacist, or making a call to a specialist pharmacy. After receiving the medication, one will be able to administer the medication on his or her own and without the frequent oversight of a medical professional.

Not long after these Genetic Treatments are made available to the public, Stem Cell Therapies will quickly become more and more advanced as well. There are even companies that have expressed a desire to take your stem cells and develop them in a laboratory environment. The goal of this treatment would be to take your own stem cells and foster the healthiest cells to multiply. After these cultures are developed, they would be mailed back to you in order for you to inject them to alleviate health conditions and other symptoms related to the aging process.

Beyond Genetic Engineering and Stem Cell Therapies, will come new forms of medical treatment that we are just beginning to research today, but will surely flourish in the coming decades: nanomedicine and femtomedicine.

Nanoscience and the Healthcare of the Future

These are tiny, genetically engineered cellular machines that will be able to improve your health by altering the functions of your body in a positive manner. They will be able to repair and alter particular forms of cells so that they function optimally, even after a period of long life in which you would expect to see physiological breakdown. It is even believed that these treatments can also preserve and repair the brain itself! Isn’t that exciting?

There are countless people in the world that have a litany of big dreams, more than they could ever hope to accomplish in a single lifetime in some cases. They have these long checklists of things they want to do in their life, a whole wide world they want to explore. Some have an unquenchable thirst for knowledge, and want to read thousands of books or learn dozens of languages in their life.

There are countless more people that have spent their early lives living on the edge, and suffer from issues such as alcohol dependency or drug addiction which have harmed their bodies and their brains. With these forms of genetic and nanomedicine, it will be possible to repair the bodies and minds of these individuals, allowing them to make a fresh start. It is possible that addiction itself may become a historical curiosity as a result of these medical advances.

What Would Do If You Had 200 More Years to Live?

  • Would you learn to play multiple musical instruments?

  • Would you research for decades in order to write the perfect novel?

  • Would you visit every country on earth?

The number of dreams that humans have yearned for is nearly infinite, and most never live to achieve all of their dreams, if they achieve any of their dreams at all. If you are still alive in the near future, around 2032, you will be able to take full advantage of what Longevity Medicine and Anti-Aging Therapy have to offer!

Some time in the future, we will finally overcome the condition of aging. We will be able to prevent all illness and be able to live in perpetuity, as long as we don’t succumb to an accident or similar fate. This is the extreme vision of Immortality Medicine.

The First Immortals Could be Alive Today!

By the time we make it to the 22nd century, there will already be individuals that have taken the road to Hyperlongevity, and there will likely be millions of humans that have taken part in this great leap forward into Post-Humanism. They will not only be healthier, but smarter too, with further advances in Genetic Science that allow us to amplify the capacity of our brains.

As people continue to develop down this evolutionary road, will we even consider them humans anymore? They will represent a new version of humanity, and they will likely use a new term to define themselves, whether that be Neohuman or some other clever word or phrase.

I believe that this advance into Neohumanism will also lead to a new era in space travel and human colonization. With these extensive lifespans, many Neohumans will inevitably turn their eyes to the stars in a desire to find new worlds and discover new lands and extraterrestrial lifeforms. Brave Neohumans from all over the planet will take to interplanetary space vessels in order to colonize and experience new worlds and lands that are beyond the scope of human imagination.

Can I Live to Experience This New Era of Humanity?

All of the things we’ve discussed may seem incredibly exciting to you, but we understand that these innovations are going to come in the near future. If you want to take part in this grand human experiment, it’s important that you live long enough to seize these innovations as they come! There are steps you can take now to alleviate the negative symptoms of the aging process and increase your odds of experiencing the new, human revolution.

My suggestions will not ensure that you will live for the next twenty years or longer, but they will potentially drastically decrease your mortality risk so that you are able to seek out this new and exciting future that we have laid before you.

Today, the door to Neo-Humanism, Hyperlongevity, and even Human Immortality is slightly open, and there are many alive today that will experience these magnificent and life-altering advances.

Will You Take Advantage of the Advances of Hyper-Longevity and Anti-Aging Medicine? Are You Willing to Commit to a Longer and more Youthful Life?

It’s quite plain to see that we are at the crest of an event horizon, beyond which it will truly be possible to lengthen lifespans indefinitely. The most important thing is to breach that horizon. By taking steps to increase health and lifespan now, you allow yourself the opportunity to take care of further, greater medical enhancements down the road.

The most modern advances available today are in the form of Recombinant Hormone Replacement Therapies. By optimizing your hormone balance, you increase the odds that you will live long enough to experience the new, up-and-coming breakthroughs of the mid-21st century.

If you live just a few more years, new genetic medical treatments will become available which will significantly increase your lifespan. While you are enjoying the benefit of genetic medicine, researchers and medical scientists will advance and perfect Genetic Therapy and Stem Cell Therapy, allowing you to live even longer!

There are a number of Stem Cell and Gene Therapies going through clinical trials as you read this, which show great promise in preventing or treating serious illnesses which severely inhibit lifespan today. As the medical community becomes more adept at using these new tools for the purpose of treatment, they will begin to utilize these treatments as forms of Positive Medicine.

They will be able to treat patients before they even get sick in order to optimize their health and greatly improve lifespans as a result, because the incidence of illness will decline significantly. In addition, these same treatments will be able to streamline existing physiological processes, keeping the body physiologically stronger and more youthful. They will be able to tailor these treatments uniquely to the individual in order to give the best care to each individual patient.

Stay on the Cutting Edge of Longevity Medicine to Perpetually Extend the Human Lifespan

With each of these breakthroughs and treatments, we will come one step closer to Immortality. Eventually, scientists and researchers will crack the code of human life, and finally figure out how to allow us to truly live indefinitely. It may take 100 years or it may take 500 years to achieve true Immortality, but each life-extending advance will allow people to survive until the next great advance. Hyper-Longevity will eventually become a universal reality, barring accident, war, or any other form of life-ending catastrophe.

You may feel that this is a science fiction world that I am describing, but it very well may be possible for you to experience this all for yourself. It is estimated that at some point between 2032 and 2052 we will have perfected medical practices which allow us to live significantly longer lives than we do today. Those that are optimistic feel that we are just twenty years away from this era, while those that are more cautious suggest that fifty years would be a more reasonable estimate.

Twenty to fifty years may not seem like that long in scientific study, but in terms of your own life, it is a significant period of time. Are you willing to make the sacrifices now in order to experience Hyperlongevity in the near future?

Eight Ways to Extend Your Lifespan

There are a lot of steps that you can take in your life today in order to significantly increase the odds that you survive to experience this new and amazing future. If you follow the suggestions below, conscientiously, you will maximize your potential to extend your life until further longevity advances develop in the coming decades.

These eight factors have been shown to be most important when determining the length of an individual’s lifespan:

  • Nutrition

  • Exercise

  • Environment

  • Social Circles

  • Vice

  • Climate

  • Calorie-Restricted Diet

  • Hormone Replacement Therapy

The Diet of the 21st Century: Caloric Restriction and Fasting for a Longer Life

A recent article in Newsmax Health explained that the future of longevity isn’t fad dieting or strenuous exercise, but a Calorie-Restricted diet which manages metabolism and ensures a long and healthy life.

Over the last century, there have been more than twenty thousand studies regarding caloric restriction in animal species from around the globe. All of these studies have unequivocally shown that restricting the calories in an animal’s diet has the ability to significantly increase the lifespan, and the same appears to apply to human beings..

This may sound like a starvation diet at first, but conscientiously and significantly restricting calories in the human diet is a powerful means to a longer life. Of course, most people consume at least 1500 calories per day and some consume several thousand! But, it appears that the sweet spot for human longevity is quite a bit lower than that 1500 calorie threshold.

For those that are struggling with Caloric Restriction, especially those that are currently overweight, HCG Injections can help relieve the feeling of hunger associated with the initial phase of the diet in order to acclimate to their new dietary lifestyle more effectively.

At first it may seem counter-intuitive, that too much of the Bread of Life can actually shorten the lifespan, but that absolutely seems to be the case. A diet that provides high levels of nutrients through the consumption of a small number of calories is the number one way to increase human longevity effectively. Intermittent Fasting and Caloric Restriction slow down aging and also reduce the incidence of a wide variety of illnesses that plague so many in America today.

The Modern Media and the Culture of Food in the West

In the United States, as well as other countries in the West including the United Kingdom, children were raised in a reality in which starvation was one of the greatest evils of the 19th and 20th century. The various forms of media available all showed the terrible fates of so many who were denied the food needed to live. Nowhere is this imagery more vivid in Western Civilization than in the footage captured after the end of World War II as the true horrors of the Holocaust were revealed to the world at large.

During the Cold War we also experienced further evidence of the horrors of famine as communist Russia and China struggled with providing their populations with proper nutrition, leading countless to die of starvation over many decades. Today, on modern television, there are advertisements for charities throughout Africa and Asia which show the plight of the starving in these third world nations.

I do not mean to discount the real and significant struggles that those that came before us experienced in the not so distant past, but it had a powerful impact on food culture in the West, particularly the idea that it is better to eat too much than too little. In our elementary education and beyond, we are confronted with story after story of mass famine, and it seems that part of the way that we culturally appreciate our current abundance is by partaking in it.

This appreciation for our abundance has led directly to a culture of overeating that borders on obsession. In the West, we simply love our food too much, and the expansion of cuisine in the West has allowed anyone to get whatever they want, when they want it, whether they go to the grocery store, the pizza parlor, or the Chinese buffet.

A Culture of Overeating Develops into a Culture of Force Feeding

Throughout the twentieth century, we have always been taught that we need to eat every last bite on our plates. Often times, we were also strongly encouraged, if not forced, to go back for a second portion. In addition to this, the proliferation of soda drinks has led directly to a significant increase in the empty calories that the average American consumes.

As the twentieth century barreled on, parents on average had less time to cook and prepare meals at home, which led to the greater proliferation of both fast food and microwavable dinners, loaded with sugars, salts, and carbohydrates which increased our caloric consumption even more!

During this age, restaurants like Burger King and McDonald’s became the captains of the fast food industry, generating billions of dollars in profit funneling cheap calories into the mouths of men, women, and children all across the country.

Because of all these pressures to overeat, the longevity gains that people in the West experienced as a result of modernization all began to slip away, the combination of unhealthy eating and an increasingly sedentary lifestyle is threatening today’s generation with the prospect of living shorter lives than their parents on average!

The United States would be stronger in every way, if it could foster greater consciousness about the importance of eating smarter to eat longer. If we all just made the proactive decision to engage in a lifestyle of at least mild caloric restriction, it would both decrease the price of health care and allow the citizens of this nation to live longer, happier, and healthier lives.

Do You Dream of a Healthier, Happier Life? Contact the Conscious Evolution Institute Today!

If you are a man or woman over the age of thirty and currently live in the United States, the Conscious Evolution Institute can help you improve your health and longevity. We provide Doctor-Monitored Bio-Identical Hormone Replacement Therapy to patients all across the United States.

With just a simple phone call, we can arrange for you to meet with one of our affiliate physicians in order to set you on the road to a new you. We offer a variety of Hormone Replacement options, including Testosterone Replacement Therapy, Human Growth Hormone Injections, Sermorelin Acetate Injections, and HCG Injection Therapy for Weight Loss.

We also provide nutrition and lifestyle counseling in order to help you maximize the results of your treatment by choosing foods, supplements, and exercises that will get your body running on all cylinders!

If you feel that you may be a candidate for Hormone Replacement Therapy, don’t hesitate, call us today, and one of our friendly specialists will walk you through the process and answer any and all questions that you may have.

For more information on Ten Ways To Live Ten Years Longer check out

Recommendation and review posted by Guinevere Smith

Somatic Cell Gene Therapy and Germ Line Gene Therapy – IPTV

Posted: April 28, 2017 at 12:48 am

There are two basic “classes” of gene therapy. Somatic cell gene therapy and germ line gene therapy.

Somatic cell gene therapy changes/fixes/replaces genes in just one person. The targeted cells are the only ones affected, the changes are not passed on to that person’s offspring.

Germ line gene therapy makes changes in the sperm or egg of an individual. The changes that are made, adding or subtracting genes from the person’s DNA, will be passed on to their offspring. This type of gene therapy raises a lot of ethical questions because it impacts the inheritance patterns of humans.

For more information, listen to Dr. Charles Link in Viewpoints.

Gene therapy can be accomplished “ex-vivo” or “in-vivo.” Ex-vivo means the target cells are removed from the patient’s body, the genes are fixed or replaced, and the cells are put back into the person. In-vivo means the genes are “injected” somehow, usually using a virus as a way to deliver the fixed or missing genes.

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Somatic Cell Gene Therapy and Germ Line Gene Therapy – IPTV

Recommendation and review posted by Guinevere Smith

High-Stakes Meeting Between Avexis and FDA Will Set the Course … –

Posted: April 28, 2017 at 12:48 am

A small drug company flies to Washington, DC for a high-stakes meeting with FDA officials. If the meeting goes well, the company secures the permission of regulators to start a pivotal clinical trial for a therapy designed to treat kids with a rare, inherited and fatal disease. Investors are very pleased.

If the company blows it, FDA officials exit the meeting with concerns and questions requiring answers. The start of the pivotal clinical trial is delayed. Precious time is lost. Investors are dismayed.

This is the crucible facing Avexis (AVXS) and its promising gene therapy for spinal muscular atrophy, AVXS-101. The company’s meeting with the FDA is scheduled for Monday.

Later this quarter, Avexis hopes to start a pivotal clinical trial of AVXS-101 in infants born with the most severe and fatal type 1 form of SMA, a rare, genetic condition affecting children that causes the loss of motor neurons in the spinal cord and lower brain stem, resulting in progressive loss of muscle function.

But before the first patient can be enrolled, Avexis executives must convince FDA officials that it knows how to make sufficient quantities of AVXS-101 to meet the demand of SMA patients. Avexis must also prove to FDA that each batch of manufactured AVXS-101 can pass quality checks to ensure patients are receiving a reliable and potent therapy.

When it comes to drug development, investors focus mostly on a drug’s efficacy and safety. Much less time is spent considering the importance of drug manufacturing, even though it is a vital step to get right if a drug is to be approved.

And so on Monday, May 1, Avexis and the FDA will sit down together for what is known in regulatory jargon as a “Type B” meeting to discuss chemistry, manufacturing and controls, or CMC, for AVXS-101.

Avexis should exit Monday’s meeting with a good sense of how the agency feels about its manufacturing plan, but the company intends to wait for FDA to send the minutes of the meeting — basically a document outlining the agency’s conclusions and recommendations — before informing investors. Avexis should receive those meeting minutes towards the end of June.

To date, Avexis has only treated 15 Type 1 SMA patients in a single clinical trial. The AVXS-101 used in the study was made in a lab at Nationwide Children’s Hospital (NCH) in Columbus, Ohio, where the gene therapy was invented.

Continued here:
High-Stakes Meeting Between Avexis and FDA Will Set the Course … –

Recommendation and review posted by Guinevere Smith

World’s first gene therapy to be withdrawn in from market in Europe … – Science Business

Posted: April 28, 2017 at 12:48 am

Four and a half years after making history and getting European Medicines Agency approval for the first gene therapy in a regulated market, uniqure NV is throwing in the towel and will not apply for the license to be renewed when its expires on 25 October.

The decision is not unexpected: only one patient has been treated with the commercial form of 1.1 million therapy since its approval. While the company hoped the European approval would pave the way to getting the nod from the FDA, the agency asked for two further trials, forcing uniqure to abandon its plan to market Glybera in the US.

The decision to not pursue marketing authorization renewal of Glybera in Europe involved a thoughtful and careful evaluation of patient needs and the clinical use of the therapy, and is not related to any risk-benefit concern, Matthew Kapusta, chief executive officer of uniQure. Glybera’s usage has been extremely limited and we do not envision patient demand increasing materially in the years ahead.

Although uniqure was blaming high exclusion criteria rather than cost, for the commercial failure of Glybera, the withdrawal sends a signal that Europes hard-up healthcare systems are not prepared to pay for innovative therapies being developed by its biotech companies. Glybera is only reimbursed in Germany and Italy.

After 14 years in development and a great deal of controversy, in October 2012 the European Commission granted a five-year marketing authorisation for Glybera, a treatment for a rare inherited disorder which prevents patients from digesting dietary fat.

Special terms attached to the authorisation required the company establish a global registry for the long-term surveillance of patients, conduct a post-approval clinical study, submit for annual regulatory reassessments and implement additional risk management procedures.

Uniqure said this meant it has to pay for significant infrastructure, including maintaining a commercial manufacturing facility, developing, developing and validating numerous assays and supporting regulatory interactions and inspections.

The axeing of Glybera will add to the pressure that is building in Europe for a new approach to reimbursement of expensive one-off cell and gene therapies. That would allow companies to get a return on investment without creating an unsustainable financial burden for healthcare systems.

Although the 1.1 million price tag of Glybera looks excessive, its effects are long-lasting. A one time, single-administration gene therapy, which introduces copies of natural LPL gene to produce functional LPL enzyme, provides a long-term therapeutic effect, currently documented up to six years from administration.

Comparable enzyme replacement therapies require continuous administration and cost 150,000 – 450,000 per year.

Amsterdam-based uniQure said it is talking to the European Medicines Agency (EMA) to discuss steps to wind down various Glybera-related activities and review plans for ongoing patient monitoring.

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World’s first gene therapy to be withdrawn in from market in Europe … – Science Business

Recommendation and review posted by Guinevere Smith

SMA Gene Therapy Promising in Early Results | Medpage Today – MedPage Today

Posted: April 28, 2017 at 12:48 am

BOSTON — Early results from a small phase I trial of a gene therapy for spinal muscular atrophy (SMA) were promising, with many children hitting milestones not typically seen in the condition, researchers said here.

In the latest update from the trial of AVXS-101, all 12 young patients were able to bring their hand to their mouth, 11 had good head control, 11 could sit without assistance, and nine could roll over, Jerry Mendell, MD, of the Center for Gene Therapy at Nationwide Children’s Hospital in Columbus, Ohio, reported during the clinical trials plenary session at the American Academy of Neurology (AAN) annual meeting here.

Two patients crawled, stood, and walked independently, and eight could actually speak, Mendell reported, adding that the latter is “one of the remarkable things you see in this trial, which you never see in SMA.”

Claudia Chiriboga, MD, MPH, of Columbia University Medical Center in New York City, who was not involved in the study, said the early data are “very encouraging, showing a robust response in respiratory, nutritional, and motor function.”

But she cautioned that the findings are only “proof of concept” — albeit “deserving of a larger study.”

“As with nusinersen,” Chiriboga said, “early treatment, before onset of significant respiratory or feeding impairments, was associated with better outcomes.”

SMA has received much attention at this year’s meeting, as nusinersen (Spinraza) was approved late last year. As an antisense oligonucleotide, that drug has a different mechanism of action from AVXS-101, which is a gene therapy delivered via AAV9 viral vectors.

Mendell noted that SMA Type 1 is a fatal disease, with only 8% of children surviving or remaining free of permanent ventilation at the age of 20 months.

For the study, the researchers conducted a single-site, open-label, dose-escalation IV infusion of AAV9 virus carrying the SMA gene. Patients had to be diagnosed with SMA before age 6 months, had to have bi-allelic SMN1 gene mutations, and have two copies of SMN2.

The primary endpoint was safety and tolerability, while the secondary endpoints were time to death or a surrogate of time to 16-hour ventilation continuously for at least 2 weeks.

Mendell discussed two cohorts: The first enrolled three patients who were dosed with 6.7E13 vg/kg of the viral vector, in which two patients survived event-free for over 30 months. One patient required respiratory support around that age.

Seeing good safety, the researchers launched a second cohort of 12 patients, who were dosed with 2E14 vg/kg of the viral vector.

Mendell reported that the first patient has survived event-free for over 30 months, and nine have reached event-free survival at 20 months. Every patient achieved event-free survival at 13.6 months.

In terms of nutritional support, respiratory support, and bulbar muscle function, six of the seven children who did not require feeding at study entry continued without nutritional support; seven of the 10 who did not require BiPAP support at study entry continued without any BiPAP; and no children hospitalized for respiratory illnesses required a tracheostomy or prolonged invasive ventilation.

Nearly all the children (11 of the 12) are feeding orally, including six who are feeding exclusively by mouth, Mendell said. Additionally, eight of 12 are able to speak.

“It’s very gratifying when you see that eight of these kids are actually speaking,” Mendell said.

In terms of safety, the team saw no new adverse events since the initial report last October. At that time, there were five treatment-related adverse events, two of which were classified as serious based on FDA criteria for asymptomatic elevated liver function enzymes.

Of the 251 non-treatment-related adverse events, 10 were classified as serious, as they were infections that required hospitalization — but all patients recovered without incident, Mendell said, concluding that the overall safety profile looks good and that the drug is generally well tolerated.

“The safety record here is impeccable,” he added.

In a motor milestone achievement assessment of cohort 2 that was adjudicated by an independent external reviewer in January 2017, the researchers saw that all patients were able to bring their hand to their mouth, 11 had good head control, nine could roll over, and 11 can sit without assistance — nine of them can sit more than 5 seconds, seven can sit more than 10 seconds, and five could sit more than 30 seconds.

Those numbers have since increased, Mendell said. In data collected since that time, 10 children can now sit for at least 5 seconds, nine for at least 10 seconds, and eight for 30 seconds or more.

In addition, two patients crawled, stood, and walked independently. Mendell noted that the published natural history shows no SMA Type 1 patients achieving any motor milestones.

During the plenary, Mendell played a video of one 18-month old patient walking independently, carrying a bag, and reaching up to press an elevator button at the hospital — a clip that was met with enthusiastic applause from physicians attending the plenary session.

“When you examine him, it just about takes your breath away,” Mendell said.

But questions remain about how long a single infusion of AVXS-101 will last, and whether patients can receive additional infusions if necessary.

“It’s an interesting question in the gene therapy world, and we’re still trying to understand that,” Mendell said. “Much depends on how long the promoter will continue to function. If that promoter shuts down using this serotype, we do have the potential for readministering the virus. … We could also administer a different serotype. There’s great potential here, and we’re very optimistic.”

Mendell reported having financial relationships with AveXis and Sarepta.


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SMA Gene Therapy Promising in Early Results | Medpage Today – MedPage Today

Recommendation and review posted by Fredricko

First gene therapy drug proves a flop in the market – Engadget – Engadget

Posted: April 28, 2017 at 12:48 am

You see, Glybera carries a whopping $1 million price. That’s not so bad when it’s a one-time treatment — as CBC points out, there are drugs that cost hundreds of thousands of dollars per year that people may have to take for the rest of their lives. However, the rarity of the disease Glybera targets meant that UniQure didn’t exactly have an abundance of medical data to show that the treatment worked as promised. In fact, just one person received the drug in five years. While that was thankfully effective, it’s tough to ask insurers and health care providers to fork over so much money for something so relatively untested.

This doesn’t mean that commercial gene therapy drugs are dead… far from it. There are already late tests underway for treatments that cover more frequent conditions, like Duchenne muscular dystrophy. However, the failure suggests that how gene therapy is sold may be as important as how well it works. While the approach is still relatively exotic, it’s not so exotic that pharmaceutical companies can charge a premium or expect to turn a serious profit. Not for a treatment that targets a rare disease, at least. Until gene therapy drugs are relatively commonplace, pharma brands may have to accept that they won’t get as much of return on investment as their patients.

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First gene therapy drug proves a flop in the market – Engadget – Engadget

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Pulling the Plug on the First Gene Therapy Drug – PLoS Blogs (blog)

Posted: April 28, 2017 at 12:48 am

2017 is supposed to be the year that FDA finally approves a gene therapy. But last week, the company behind the first approved gene therapy in Europe,, announced that it wont pursue the renewal of marketing authorization that expires October 25.

What happened? Is the move a setback for gene therapies in the pipeline? I dont think so.

Headlines echoed the news release from the Netherlands-based company:

Biotech Firm Pulls Pioneering Gene Therapy Due to No Demand

First Gene Therapy Ever Approved Calling it Quits

The Worlds Most Expensive Medicine is Being Pulled from the Market

A$1.4 milliondrug doesnt seem to make sense, but I dont think seeking an immediate fortune was ever the intention for Glybera, used to treat an enzyme deficiency. DNA Science covered much of the story in New Miracle Drugs: What WouldYou Pay?

My book about gene therapywas published in 2012, the year that the European Medicines Agency (EMA) approved Glybera. I was certain that the first approvals in the US would come within, at most, three years. The book focused on what is now calledRPE-mediated inherited retinal disease, but back in 2012 was Leber congenital amaurosis type 2. That trial has had spectacular results; phase 3 results havent been published yet. Other candidates include two forms of severe combined immune deficiency (SCID-ADAand SCID-X1), two leukodystrophies (ALD and MLD), and perhaps forms of Batten Disease, Sanfilippo syndrome, or hemophilia.

The first clinical trial for gene therapy in the US began in 1990. Glyberas rootsreach back to a few years before that, to the laboratory of Michael Hayden at the University of British Columbia.


Id heard presentations from UniQure scientists at meetings, and chatted with some of them when I had a table to sell my books at the PhacilitateCell and Gene Therapy meeting in Washington, DC, in late January 2013. Because of the book, the editors of that months print Scientific American, The Future of Science issue, had asked me to contribute a one-page piece on gene therapy.

At that meeting, UniQures chief business officer, Hans Preusting, discussed Glyberas development. He and others readily acknowledged the high price, but stressed that the treatment could establish a vector gene-delivery system that would work, like a cassette player, for other indications. I envisioned a future facility into which different loaded gene therapy vectors could simply plug in, like those places where you get different flavors of frozen yogurt oozing from separate spigots.

Costs would eventually come down. Remember when hand-held calculators were stand-alone devices selling for $100?

Glybera treats what was then called lipoprotein lipase deficiency but is now also called familial chylomicronemia syndrome (what is it with changing disease names???). It causes extremely high blood triglyceride levels and, in some patients, recurrent excruciating abdominal pain. Rash and enlarged liver and spleen are also part of the picture. Some of the worst cases are in children and teens.

Existing triglyceride-lowering drugs are ineffective because the cause differs. So the only approach, nearly impossible to do, is to eat as little fat as possible. The gene therapy is delivered in 42 injections into leg muscles, once, with a viral (AAV1) vector. The disease affects one in a million people.

The regulatory road, said Preusting, was rocky. We started the submission dossier at the end of 2009 and it was validated by EMA in January 2011. Milestone assessments brought hundreds of questions. EMA and the Committee for Advanced Therapies (CAT) said the data were not convincing enough, due to the small dataset, to say theres a clinical benefit from Glybera. But it wasnt a unanimous decision, so they encouraged us, he said.

The company, then known as Amsterdam Molecular Therapeutics (AMT), went back to work and then refiled Glybera as an ultra orphan drug regulated for exceptional circumstances the sickest patients. This time CAT approved it but the Commission for Medicinal products (CHMP) in humans still said no.

Preusting provided the business view. We were publicly traded in Amsterdam. The stock decreased by 50% after the first non-approval, and again after the second. In that moment in time we were a penny stock. How do you finance a company with hardly any value? Fortunately we had very loyal investors. We took AMT off the stock market and founded a new company, private, UniQure.

Then, surprisingly, the EMA asked the CHMT to look at the data again and when they did they saw clinical benefit for the 14 sickest patients out of an original 27, assessed by lowered frequency of pancreatitis attacks. Their lipid levels fell and they could eat foods they couldnt tolerate before. One patient even had a baby.

By July 2012, both CAT and CHMP were on board. This was a major major event in the space of gene therapy, for the whole field, said Dr. Preusting.

By October, Glybera received final approval under exceptional circumstances with a five-year marketing authorization. Patients began treatment in 2014.

Since then, whether or not to test a gene therapy on the sickest patients has evolved to depend on the nature of a disease. For Glybera doing so led to approval, but in one publicized case in the U.S., two young daughters of well-connected Hollywood parents received gene therapy for a form of Batten disease when the younger child had not yet shownsymptoms. For some gene therapy trials older children are too sick to meaningfully respond and yield useful information. Hannah Sames, whom Ive written about many times, was just weeks from being too sick to have her gene therapy for giant axonal neuropathy last July.


Oddly, the folks at UniQure had read my one-pager in Scientific American, but had no idea Id written a book about gene therapy. Based on that, they asked me to participate in Investor Day in midtown Manhattan a year after Id heard Dr. Preusting at the gene therapy conference, January 2014. I was to give a short, introductory overview of the space, a term I usually associate with the final frontier.

Im used to speaking at biology conferences, where the dress code is, er, casual. But a Wall Street crowd? I sent snaps of myself in business suits from the dressing room of Talbots to the nice PR people for UniQure, and the powers-that-be shaped my presentation to cover the diseases in their pipeline. (Disclosure: I was paid.)

After the talks came the panel discussion, livestreamed. I was placed front and center, being the only XX, and was mortified when I wasnt asked a single question. But I was encouraged that many in the audience of investors were female scientists.

The conference focused more on the pipeline, such as hemophilia B and Huntington disease, than Glybera. But honestly I dont remember much about Investor Day, not because it was more business than science, but because when I was headed back upstate on Amtrak, my daughter called to tell me that just after Id left, Bruce Springsteen and Bono had given an unannounced, free concert 2 blocks from the meeting!!! She had waited until my train was north of Poughkeepsie because she knew Id leap from it.


The decision not to renew Glyberas marketing authorization is based on numbers, not safety or efficacy. It works, for the right patients. But costs for long-term surveillance and continuing clinical study proved prohibitive.

Glyberas usage has been extremely limited and we do not envision patient demand increasing materially in the years ahead, the news release quoted uniQure CEO Matthew Kapusta.

According to Rare Disease Report, only one patient actually paid the $1.4 million for Glybera. About 500 people in Europe have the disease and 323 in the US.

My brief foray into the business side of gene therapy reaffirms that I prefer to view gene therapys success through the lens of the kids Ive reported on: Corey, the star of my book, who would be blind without gene therapy;Eliza,who is becoming more verbal since her procedure; and Hannah, who can sit unaided and pick up small bits of food. From gains like eyesight, to the ability to sing a nursery rhyme, gene therapy is on its way despite the economic stumbles.

Gene therapys time will come, and I hope it is soon.

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Pulling the Plug on the First Gene Therapy Drug – PLoS Blogs (blog)

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