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Alan Watts – Existence is Quite Weird and Why the Apple Tree Apples Fall, Philosophy and Spirituality

Posted: June 18, 2017 at 7:36 pm



Alan Watts – Existence is Quite Weird and Why the Apple Tree Apples Fall, Philosophy and Spirituality from Endocrinology Hormone Clinic on Vimeo.

Recommendation and review posted by G. Smith

Technocalpyse Part 1, 2, 3

Posted: January 24, 2016 at 7:16 am

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The Ethics of the Future: Human Genetic Engineering and Human Immortality Medicine is Coming in 19 years!!

Posted: January 1, 2015 at 12:46 pm

The Ethics of the Future: Genetic Engineering and Immortality Medicine

2015 is Going to Be a Fascinating Year for Longevity Science

By Professor Mark

How do you feel about the potential for great advances in Human Longevity Science that have been occurring in recent years? Do you feel excited about the prospect of living a much longer life, or are you indifferent? Are you nervous about the prospects of what this sort of tinkering with genetics and human nature might bring?

Is the potential for a vastly expanded lifespan going to be something that everyone can enjoy, or will it be an advantage simply for those that can afford it? If you could live 100 years longer, would you want to? Would you care if the opportunity were afforded to you as an individual? Would such a huge opportunity lead to a new and beautiful life on earth, or would earth somehow take these momentous advantages and turn the world on its head?

My Beliefs Regarding Advanced Genetic Engineering

Many years ago, when I was an undergraduate at Penn State, our professor posited similar questions in our Genetics Class, which played a major role in affecting my beliefs toward the subject of hyper-longevity and Genetic Engineering. The class was large, with more than 100 students, and my professor asked the class what their opinions were regarding the use of genetic manipulation and engineering to alter human life.

Surprisingly, the class was completely silent. In response to this silence, the professor called up two students to debate the subject. One of my classmates volunteered to voice his opposition to genetic engineering, and I chose to volunteer, providing an argument in favor of it.

My opponent voiced his opinion to the class that genetic engineering for this purpose would be ethically wrong because it is not in man’s best interest to play God. Most of our classmates seemed to agree, nodding subtly in agreement.

Personal Aesthetic: Choosing to Be Different

I felt as though I was standing upon a grand crossroads of history. As I looked around the class, it felt as though all of my classmates, for all of their cliquish differences, were being incredibly closed-minded, like they just accepted what they had been told all their lives and were afraid to think for themselves.

After the professor gauged the response of the students, I had my opportunity to argue in favor of this advanced human genetic engineering. I glanced around the class, and felt my argument come together cleanly in my mind. I saw white girls with bleached hair stretching down their backs, more than a few of which had fake breasts. I saw black girls with expensive weaves and complex and expensive hairstyles.

There were white students mimicking their hip hop and rap idols, and I even saw a young Asian student that had very obviously dyed her hair red. In my class I saw a great commingling of different styles. People both attempting to exemplify American standards of beauty and those taking on the aspects of other cultures, adopting them as their own.

As I looked around at all of this, recognizing the great diversity in my class, I had a strong feeling that there was not one person in the class that didn’t have at least one thing they wanted to alter about the characteristics they were born with. I continued thinking to myself, that these students probably wanted to be different in a variety of different ways: some wanted to be smarter, some taller. Some girls wish they had larger breasts, and some guys wanted larger penises. Others probably wish that they didn’t have to go through the trouble to put in contacts and hair dyes to look like the person they wish they were. For myself, I would have given anything just to be a few inches taller.

A Call for Genetic Freedom

After standing quietly for a moment, with all of these thoughts running through my at head a rapid place, I spoke from my position, in the back of the class, and suddenly stated loudly: Genetic Freedom!

I felt that just those two words spoke for themselves, but my professor threw a dejected glance in my direction, and I could detect her shaking her head almost imperceptibly. Her silence was a sign that she needed more. After the brief silence, I continued. I argued to the class that the individual should have full control to alter his DNA as he sees fit, so long as it doesn’t negatively impact society or the rights of anyone else.

She seemed thoroughly unhappy with the argument, and the class began to chatter loudly, nearly in unison. After the short spate of controlled chaos, the class continued with liveliness and energy, but I felt that others in the class largely shunned me as a result of the fervent beliefs I expressed in regard to what legitimately amounted to the potential future of the human race.

Will People Be Able to Resist Genetic Alteration?

I still laugh to myself to this day about how my belief met such incredulity in the face of so many. In the future, once science makes it possible to make such powerful changes to humanity at the genetic level, I am confident that these same students, if given the actual opportunity to improve themselves through futuristic genetic methods, would absolutely jump at the chance with no second thought.

It wouldn’t be Playing God. It wouldn’t be unethical. It would simply be the new reality. In fact, once the time comes to pass when Genetic Alteration becomes a reality, the exact same people today that seek out plastic surgery and cosmetic surgery will clamor for these procedures as soon as they become available. In the end, I believe I made a B in the course, which is regretful, because I’ve always remained highly interested in genetics.

The Future of Humanity: The Organic and the Engineered

Another of my professors at Penn State, himself with a doctorate in genetics, explained an interesting aspect of human evolution, one which I had never thought of before. He explained that the many races that make up humanity as a whole developed their differences as a result of dispersing far from one another, and slowly adapting to their new environments over time.

After they migrated, geography, distance, and other factors kept them from interacting heavily with one another, which caused their minor adaptations to become more pronounced. In the same way that they developed their own habits and cultures, their aesthetic and physical makeup also changed. Some grew taller, others grew paler, and each individual culture became maximally resistant to the diseases which were prominent in their area.

Even though these physical and genetic changes were significant, any healthy woman on earth could still mate with any other healthy man, no matter how different he looked or acted. What he said that truly sparked my mind was that if the different races of human beings stayed geographically isolated from one another for longer period of time, eventually the different races could have changed enough to where they could no longer produce children with one another.

Could Genetically Engineered Humans Evolve Beyond Humanity?

This can also apply to the future of genetic engineering. The modern world is so interconnected that geography has no impact on the ability of humans to breed with one another, but genetic enhancement may lead to a point at which a human born today would not be able to mate with an individual that was the result of generations of genetically altered parents.

As Genetic Engineering becomes more advanced, humans may change enough at the genetic level to prevent interbreeding between lineages which have undergone these advancements and those that chose not to. This change would of course be gradual, first reducing the ability to conceive before denying that ability altogether. At this point, it would take genetic engineering just to create a viable child for two disparate humans. Interestingly enough, it may even come to pass that different species of humans evolve from such endeavors, as distinct from one another as they are from humans themselves.

The beginning of this story could begin sometime in the next hundred years, as scientists and medical specialists develop the ability to safely and effectively alter DNA to meet the specifications of the individual.

The Future is Coming: the Great Human Divergence and the Neo-Sapient

The people that choose to reject Genetic Modification and Advanced Longevity Treatments in the near future will create an interesting binary world. This could be the beginning of a grand human experiment. This could be the focal point of a genetic divergence so strong that it literally fragments the human race, creating a new class of post-humans that have advanced to a point where they qualify as their own unique species.

I think back to the genetics course I mentioned earlier. I remember the absolute ocean of diversity that was contained within the 100-student course, and I was able to visualize a future in which Genetic Modification leads to even greater diversity, and a uniqueness that has never existed in the history of the human race. It made me think of the diversity of the universe, and the unlimited options for diversity that it represents. As someone with an affinity for astronomy, I find it utterly inconceivable that planet earth is home to the only lifeforms in the universe.

Of course, along with my great optimism, I do recognize that there are risks and unknowns related to the future of Genetic Modification. There is even the potential that the science behind Genetic Modification could be used for Genetic Warfare. There is certainly the potential that the same science that creates a new humanity could be used to destroy large swathes of it. I can imagine an apocalypse that is not nuclear and grandiose, but genetic and nanoscopic.

Post-Humanism and the Search For Other Worlds

In the end, will humans be able to develop interplanetary travel and colonization in order to insure itself against such potential apocalyptic scenarios? It’s a subject that I am particularly concerned with, and is the core reason why I support NASA and the United States Space Program. As the world moves faster and the dangers become greater, it is imperative that we are able to save humanity even in the case of a state of mutually assured destruction.

If there truly is a Genetic Revolution on the horizon, it is vitally important that we use all of the resources we have available in order to make our dreams of space colonization a reality. Imagine a future so spectacular: A future where a multitude of post-human species advance outward from earth in order to colonize space like a rainbow across the galaxy.

This journey will be arduous and epic, as earthlings spread across the cosmos in order to find new viable homes and potentially interact with other life forms.

What Would Aliens Be Like?

Can you imagine how literally otherworldly that would be? If we found advanced aliens, would they have unlocked the key to eternity? Would we have done the same? There is no doubt that the first time that we make contact with an extraterrestrial species, they will come from worlds and cultures which are absolutely unimaginable in the face of everything that we have experienced.

I may have delved a bit into the realm of science fiction, but the future of humanity in the face of Genetic Modification has the potential to be every bit as exciting and otherworldly as the potential future that I just described. It instills a tremendous sense of fear, awe, and most importantly, unlimited potential.

Do You Think That You Could Handle Immortality?

If you ask the average person out on the street about the potential future afforded by Genetic Engineering, Advanced Longevity, and Immortality medicine, you’ll likely get a number of different responses, some positive, some negative, others simply incredulous. If you surveyed 100 people, I believe that you would find that the majority would ultimately reject the idea of immortality.

Some people think that eternity would take the excitement out of life. Others fear that they would eventually just become a broken shell of their former selves as their bodies physically decline in spite of science’s ability to prevent death. For many, the concept of eternity is just as fearsome as the concept of death itself. It’s not all that different from the way that people feel about retirement these days. They are frustrated because they have to work so hard all through the healthiest part of their lives only to be too frail and broken down by the time they retire to enjoy it.

Longevity Medicine and the Future

That’s why Longevity Medicine is so important. We want our retirement years to last as long as possible, and we want to be able to enjoy them. Maybe one day, we will be retired as long in our lives as we are at work, or longer! That’s what the approach to immortality will be like!

There are a growing number of people that are optimistic about a lengthy future. They understand that even with regard to a concept like immortality, life is the sum of individual experience. Some will take advantage of a life bordering on immortality, while others would simply choose to be boring. People that live lives full of happiness and vitality shouldn’t be deprived the opportunity to extend that joy, simply because there are others who wouldn’t appreciate it!

The arguments stemming from the subject of Human Immortality continue to become both more interesting and more complex, both for those that long for such a fate, and those that oppose the concept. No matter how you feel about the idea of Advanced Longevity, there is no doubt that such opportunities to live lives we now consider unimaginable will eventually come to pass.

As long as human beings are able to engage in scientific advancement without destroying ourselves or sending ourselves back to the stone age, such opportunities will present themselves to the human race in the near future.

Gene Therapy and Stem Cell Therapy: The First Steps to Hyperlongevity

The seeds of these future endeavors are being planted today, in the fields of gene therapy, genetic medicine, and stem cell therapy. This is also the core concept behind medical treatments which seek to optimize hormone production in the body in order to alleviate the medical conditions associated with hormone imbalance and aging.

Hormone Replacement Therapy: Streamline Your Body for the Future!

Treatments such as Testosterone Replacement Therapy, Sermorelin Acetate Therapy, and Bio-Identical Human Growth Hormone Replacement Therapy seek to correct common hormonal imbalances that occur as a result of the aging process. There is even a strong argument that these hormone imbalances are actually the root cause of many symptoms of aging, including frailty, osteoporosis, and cognitive decline.

There are many Health, Wellness, and Longevity Physicians that believe that these forms of Hormone Replacement Therapy are some of the must effective means to prolong a healthy and active life when used in combination with a healthy and conscientious lifestyle. These medical treatments are the best way to decrease your mortality risk so that you are more likely to experience the next great advancement in Anti-Aging Medicine.

If you feel that your quality of life has been on the decline as a result of changes in your body and mind resulting from the aging process, I strongly encourage you to get your hormone levels checked, because there is a significant chance that you may be suffering from a reversible form of hormone deficiency.

The Future of Human Genetic Engineering

This is truly an exciting time to be alive. We are quickly approaching the point at which scientific breakthroughs in health science will continue to occur at an ever-increasing pace, with groundbreaking new health advances occurring on a regular basis. The following years will be incredibly interesting, because there are a multitude of clinical trials regarding the promise and potential effectiveness of both gene therapy and stem cell therapy.

By 2012, these studies, and other similar studies, were already displaying high levels of potential to both treat and protect both animals and humans from disease. Beyond Hormone Optimization and Genetic Therapy, the next stage of advancement will most likely be in the field of nanomedicine. Beyond nanomedicine is femtomedicine.

At this stage of scientific inquiry, this is as far as even the most forward-thinking physician or philosopher could imagine, but there is no doubt as we create new medical treatments and expend our knowledge of medical science, new opportunities for advancement will be conceptualized that could be even more life-altering and fantastic than those that we just mentioned.

When you consider the future of medicine and longevity, you realize that human beings as they are now aren’t simply the end result of millions of years of evolution, but also a gateway to the next state of terrestrial life, a transitional state between what was and what will be, an opportunity to experience even greater consciousness and enlightenment by conquering time, itself.

What is the Idea Behind Human Immortality?

When we discuss the idea of human immortality, it doesn’t just mean allowing a human being to live forever, human immortality represents the idea that it will be possible, with future biomedical and genetic enhancements, for human beings to experience a practical immortality in which one is able to live as they were in the prime of their life, for all of their life.

It seems just as you master your body and your mind in the late twenties and early thirties, your body and mind start to enter a slow and unstoppable decline. What if you could preserve that period of physical and psychological perfection forever? It is during this period that the average person reaches his or her functional peak as an individual, with regard to strength, cognitive ability, immunity, and overall health.

How Much Better Would Life Be if You Lived to 200?

Think about how different and exciting that life would be if you could have the body and mind of a 29 year old for 120 years. There are a number of people that think that humans should not have this opportunity, but it sounds much better than spending the whole sum of those years in slow and steady decline.

How Much Better Would Life Be if You Could Live Indefinitely?

Immortalists subscribe to the belief that individuals that truly enjoy life and are creative or passionate enough to find interesting or fulfilling things to do would be able to easily take advantage of a significantly lengthened lifespan. I do understand how such a long life would feel to someone that lacks passion or imagination, however. I can imagine two hundred years of absolutely drudgery. If one does not have the propensity to invest or save to create wealth, I can imagine two hundred years of hard work with nothing to show for it.

With luck, a more automated world would allow us to enjoy our lives while actually working less. Imagine a world of eco-friendly machines could do the work of one hundred men. This could be a wonderful world of leisure for all, but it could also lead to a world where machines are used as a method of control and domination, like in Frank Herbert’s dystopian novel Dune.

The Temptation of Human Immortality

Whether the opportunity for Human Immortality comes in twenty years or two hundred years, there will be those that seek out the opportunity for such a life, and there will be those that choose to reject the opportunity for immortality.

The central question that Immortalists posit is a simple one: Why would anyone actually want to die or grow old? When you think of it that way, it sounds absolutely silly. Who would ever want to do such things? But in reality, it seems as though most human beings are resigned to such a fate.

Who Really Wants to Grow Old?

More than simply growing old, who wants to lose their lust for life or their libido? Who wants to experience their own body slowly deteriorate as they are beaten down by illness and disease? Human Immortalists are those that are willing to fight against what is perceived as inevitable by society at large. They believe that those that have resigned themselves to decay and death are simply not willing to imagine a post-human age where they could evolve beyond the inevitability of death.

It seems that many humans think of Human Immortalists as harbingers of doom which are going to bring about a new genocide. They believe that Immortalists are going against the will of God by altering the Human Genetic Code in an attempt to foster extreme lifespans, improved aesthetic, and vastly improved health outcomes.

The Great Schism of Humanity

There is a strong chance that a rift will develop between those that choose genetic alteration and those that choose to forgo such opportunities. In the end, it is likely that humanity will rift into two distinct groups. Over time, greater and greater numbers will opt for Genetic Modification, and those that opt out of such procedures may potentially lose footing in society as a result of their choice.

If modification indeed has the ability to create such disparity, genetically modified humans will spread their genes with one another, and their offspring may have greater potential for both prosperity and intellect, which will create a socioeconomic rift between GM Humans and Unmodified Humans.

Will Post-Humans be able to act ethically under these circumstances? Will Unmodified Humans be able to accept a place in the world where they are unequivocally inferior to their GM counterparts? This new world will be different and exciting, and it’s up to us to create a civil world where we can act in the best interest of all.

What Other Strange Opportunities May Become Available in the Future?

On top of our ability to vastly extend and improve our long-term health, the future will also provide us with enhanced opportunities with regard to personal aesthetic. We will not only be able to cure conditions such as psoriasis which plague millions in the world today, but many may choose to move beyond mere optimization and may choose to fully customize their appearance. Perhaps one may choose not to have olive or alabaster skin as many in society desire today, but go for a different color all together.

What if someone chose to color their skin orange, green, or blue? What if they wanted to be leopard print or covered in zebra stripes? This may appear otherworldly and unnatural to our minds, but when presented with an entire array of customization, what would be so strange about doing something like that to stand out? How different would it be to dying your hair blue or rainbow, if there were no dangers in undergoing such a change?

But, given enough time and scientific innovation, skin color and other basic augmentations like genetic breast and penis enlargement will be just another evolution in the concept of general aesthetic. The potential for more extreme changes would eventually become possible. What if humans wanted to take on the characteristics of animals? What if someone wanted the ears or tail of a cat, for example? There would even be the potential to do even more drastic things that we can barely imagine today.

Genetically Engineered Pets

These genetic advancements won’t occur in a human vacuum. They will also apply to animals as well. Today people are paying top dollar for basic genetically modified hypo-allergenic dogs, and glow-in-the-dark mammals have even been developed in laboratories.

In the future, it is likely that scientists will come up with scientific modifications which significantly enhance both the aesthetic and intelligence of animals. It’s even likely that animals will experience the benefits of genetic engineering more quickly than humans, as this future will largely be facilitated by means of animal testing.

The Post-Human Era Starts with Basic Genetic Engineering and Ends with Post-Humanism, Hyperlongevity, and Potential Immortality

You may not be able to tell, but we are already in the midst of the first phase of the Post-Human era. The beginning of this era was marked by the first time that egg and sperm from two different individuals was combined and implanted into an adoptive mother. It was such a grand event in retrospect, but the passing into this new era was not met with massive celebrations, but simply with concerns over the ethics of the new future.

Post-Humanity will have a litany of moral conundrums to unravel, some that we can imagine, and others that are unfathomable to us today. The state of the mortal mind is simply not equipped to handle the moral and ethical quandaries that the genetically modified mind will face. What if there are other lifeforms just like us in other parts of the galaxy, that have also learned to take control of their very existence on the cellular level? What if the number of unique alien civilizations in the universe is unlimited? What if we as earthlings are just one form of intelligent life among a countless litany of others?

The Current State of Genetic Modification and Gene Therapy

Today, scientists, researchers, and physicians are taking the first step into this future, with the quickly growing field of genetic therapy. We are on the cusp of doing some truly amazing things, like genetically altering viruses in order to protect humans from genetic disorders and conditions. At first, these initial treatments have been risky, reserved for those in most dire need, but as medical science becomes more well-versed in these therapeutic advancements, they will become safer and more widely available to the general public. Could you imagine reducing your risk of cancer by 80% just with a single injection? That may be the future for you.

The Current State of Organ Regeneration and Stem Cell Therapy

Another aspect of genetic therapy has to do with the advancing field of Stem Cell Therapy. There are new, state of the art treatments available which utilize stem cells in order to improve the health of the heart. Patients that have experienced heart attack or heart disease can be treated with stem cells which have the ability to develop into new and healthy muscle tissue.

Similar techniques have also been used in order to regenerate other parts of the body or parts of individual organs. In one famous case, scientists biomanufactured a windpipe for a patient with the patient’s own cells. They were able to do this by taking the stem cells and allowing them to grow in culture before pouring them over a scaffold in the shape of a windpipe. Just by providing the cells with the nutrients to grow, they were able to recreate a human windpipe in the laboratory just in a matter of days.

Because the windpipe was created from the patient’s own cells, the body did not reject the windpipe when it was surgically implanted into the body. This is one of the first successful cases where a patient’s life was changed through the scientific advancements of genetic organ replacement.

Stem Cell Therapy Will Be Available in the Near Future: Hormone Replacement Therapy is Here Today!

Stem Cell Therapy is exciting and will become increasingly common and popular over the next century in the United States. Today, there are a few places where Stem Cell Therapy is available internationally, especially in Asia, but they have yet to be medically certified, and there are still a number of pertinent risks involved. In the Western World, Stem Cell Treatments are currently going through clinical trials. Although the results are mixed, continual progress is being made.

There are many scientists that believe that Stem Cell Research will lead to a new future in medicine, but policies enacted during the presidency of George W. Bush have set the United States behind by at least a decade, and other nations in Europe and Asia are currently taking advantage of their head start, and may one day eclipse us in these new and futuristic medical therapies.

In just a few short years, genetic testing will become affordable enough that it will become a common and recommended part of prenatal care as well as regular checkups throughout the lifespan. Over time, more and more Genetic Disorders will be able to be effectively treated with Gene Therapy, and with every breakthrough, people will be that much more likely to live a longer and healthier life.

Once the clinical science is sound, it won’t even be a difficult ordeal for the patient. It would simply be like going to visit the pharmacist, or making a call to a specialist pharmacy. After receiving the medication, one will be able to administer the medication on his or her own and without the frequent oversight of a medical professional.

Not long after these Genetic Treatments are made available to the public, Stem Cell Therapies will quickly become more and more advanced as well. There are even companies that have expressed a desire to take your stem cells and develop them in a laboratory environment. The goal of this treatment would be to take your own stem cells and foster the healthiest cells to multiply. After these cultures are developed, they would be mailed back to you in order for you to inject them to alleviate health conditions and other symptoms related to the aging process.

Beyond Genetic Engineering and Stem Cell Therapies, will come new forms of medical treatment that we are just beginning to research today, but will surely flourish in the coming decades: nanomedicine and femtomedicine.

Nanoscience and the Healthcare of the Future

These are tiny, genetically engineered cellular machines that will be able to improve your health by altering the functions of your body in a positive manner. They will be able to repair and alter particular forms of cells so that they function optimally, even after a period of long life in which you would expect to see physiological breakdown. It is even believed that these treatments can also preserve and repair the brain itself! Isn’t that exciting?

There are countless people in the world that have a litany of big dreams, more than they could ever hope to accomplish in a single lifetime in some cases. They have these long checklists of things they want to do in their life, a whole wide world they want to explore. Some have an unquenchable thirst for knowledge, and want to read thousands of books or learn dozens of languages in their life.

There are countless more people that have spent their early lives living on the edge, and suffer from issues such as alcohol dependency or drug addiction which have harmed their bodies and their brains. With these forms of genetic and nanomedicine, it will be possible to repair the bodies and minds of these individuals, allowing them to make a fresh start. It is possible that addiction itself may become a historical curiosity as a result of these medical advances.

What Would Do If You Had 200 More Years to Live?

  • Would you learn to play multiple musical instruments?

  • Would you research for decades in order to write the perfect novel?

  • Would you visit every country on earth?

The number of dreams that humans have yearned for is nearly infinite, and most never live to achieve all of their dreams, if they achieve any of their dreams at all. If you are still alive in the near future, around 2032, you will be able to take full advantage of what Longevity Medicine and Anti-Aging Therapy have to offer!

Some time in the future, we will finally overcome the condition of aging. We will be able to prevent all illness and be able to live in perpetuity, as long as we don’t succumb to an accident or similar fate. This is the extreme vision of Immortality Medicine.

The First Immortals Could be Alive Today!

By the time we make it to the 22nd century, there will already be individuals that have taken the road to Hyperlongevity, and there will likely be millions of humans that have taken part in this great leap forward into Post-Humanism. They will not only be healthier, but smarter too, with further advances in Genetic Science that allow us to amplify the capacity of our brains.

As people continue to develop down this evolutionary road, will we even consider them humans anymore? They will represent a new version of humanity, and they will likely use a new term to define themselves, whether that be Neohuman or some other clever word or phrase.

I believe that this advance into Neohumanism will also lead to a new era in space travel and human colonization. With these extensive lifespans, many Neohumans will inevitably turn their eyes to the stars in a desire to find new worlds and discover new lands and extraterrestrial lifeforms. Brave Neohumans from all over the planet will take to interplanetary space vessels in order to colonize and experience new worlds and lands that are beyond the scope of human imagination.

Can I Live to Experience This New Era of Humanity?

All of the things we’ve discussed may seem incredibly exciting to you, but we understand that these innovations are going to come in the near future. If you want to take part in this grand human experiment, it’s important that you live long enough to seize these innovations as they come! There are steps you can take now to alleviate the negative symptoms of the aging process and increase your odds of experiencing the new, human revolution.

My suggestions will not ensure that you will live for the next twenty years or longer, but they will potentially drastically decrease your mortality risk so that you are able to seek out this new and exciting future that we have laid before you.

Today, the door to Neo-Humanism, Hyperlongevity, and even Human Immortality is slightly open, and there are many alive today that will experience these magnificent and life-altering advances.

Will You Take Advantage of the Advances of Hyper-Longevity and Anti-Aging Medicine? Are You Willing to Commit to a Longer and more Youthful Life?

It’s quite plain to see that we are at the crest of an event horizon, beyond which it will truly be possible to lengthen lifespans indefinitely. The most important thing is to breach that horizon. By taking steps to increase health and lifespan now, you allow yourself the opportunity to take care of further, greater medical enhancements down the road.

The most modern advances available today are in the form of Recombinant Hormone Replacement Therapies. By optimizing your hormone balance, you increase the odds that you will live long enough to experience the new, up-and-coming breakthroughs of the mid-21st century.

If you live just a few more years, new genetic medical treatments will become available which will significantly increase your lifespan. While you are enjoying the benefit of genetic medicine, researchers and medical scientists will advance and perfect Genetic Therapy and Stem Cell Therapy, allowing you to live even longer!

There are a number of Stem Cell and Gene Therapies going through clinical trials as you read this, which show great promise in preventing or treating serious illnesses which severely inhibit lifespan today. As the medical community becomes more adept at using these new tools for the purpose of treatment, they will begin to utilize these treatments as forms of Positive Medicine.

They will be able to treat patients before they even get sick in order to optimize their health and greatly improve lifespans as a result, because the incidence of illness will decline significantly. In addition, these same treatments will be able to streamline existing physiological processes, keeping the body physiologically stronger and more youthful. They will be able to tailor these treatments uniquely to the individual in order to give the best care to each individual patient.

Stay on the Cutting Edge of Longevity Medicine to Perpetually Extend the Human Lifespan

With each of these breakthroughs and treatments, we will come one step closer to Immortality. Eventually, scientists and researchers will crack the code of human life, and finally figure out how to allow us to truly live indefinitely. It may take 100 years or it may take 500 years to achieve true Immortality, but each life-extending advance will allow people to survive until the next great advance. Hyper-Longevity will eventually become a universal reality, barring accident, war, or any other form of life-ending catastrophe.

You may feel that this is a science fiction world that I am describing, but it very well may be possible for you to experience this all for yourself. It is estimated that at some point between 2032 and 2052 we will have perfected medical practices which allow us to live significantly longer lives than we do today. Those that are optimistic feel that we are just twenty years away from this era, while those that are more cautious suggest that fifty years would be a more reasonable estimate.

Twenty to fifty years may not seem like that long in scientific study, but in terms of your own life, it is a significant period of time. Are you willing to make the sacrifices now in order to experience Hyperlongevity in the near future?

Eight Ways to Extend Your Lifespan

There are a lot of steps that you can take in your life today in order to significantly increase the odds that you survive to experience this new and amazing future. If you follow the suggestions below, conscientiously, you will maximize your potential to extend your life until further longevity advances develop in the coming decades.

These eight factors have been shown to be most important when determining the length of an individual’s lifespan:

  • Nutrition

  • Exercise

  • Environment

  • Social Circles

  • Vice

  • Climate

  • Calorie-Restricted Diet

  • Hormone Replacement Therapy

The Diet of the 21st Century: Caloric Restriction and Fasting for a Longer Life

A recent article in Newsmax Health explained that the future of longevity isn’t fad dieting or strenuous exercise, but a Calorie-Restricted diet which manages metabolism and ensures a long and healthy life.

Over the last century, there have been more than twenty thousand studies regarding caloric restriction in animal species from around the globe. All of these studies have unequivocally shown that restricting the calories in an animal’s diet has the ability to significantly increase the lifespan, and the same appears to apply to human beings..

This may sound like a starvation diet at first, but conscientiously and significantly restricting calories in the human diet is a powerful means to a longer life. Of course, most people consume at least 1500 calories per day and some consume several thousand! But, it appears that the sweet spot for human longevity is quite a bit lower than that 1500 calorie threshold.

For those that are struggling with Caloric Restriction, especially those that are currently overweight, HCG Injections can help relieve the feeling of hunger associated with the initial phase of the diet in order to acclimate to their new dietary lifestyle more effectively.

At first it may seem counter-intuitive, that too much of the Bread of Life can actually shorten the lifespan, but that absolutely seems to be the case. A diet that provides high levels of nutrients through the consumption of a small number of calories is the number one way to increase human longevity effectively. Intermittent Fasting and Caloric Restriction slow down aging and also reduce the incidence of a wide variety of illnesses that plague so many in America today.

The Modern Media and the Culture of Food in the West

In the United States, as well as other countries in the West including the United Kingdom, children were raised in a reality in which starvation was one of the greatest evils of the 19th and 20th century. The various forms of media available all showed the terrible fates of so many who were denied the food needed to live. Nowhere is this imagery more vivid in Western Civilization than in the footage captured after the end of World War II as the true horrors of the Holocaust were revealed to the world at large.

During the Cold War we also experienced further evidence of the horrors of famine as communist Russia and China struggled with providing their populations with proper nutrition, leading countless to die of starvation over many decades. Today, on modern television, there are advertisements for charities throughout Africa and Asia which show the plight of the starving in these third world nations.

I do not mean to discount the real and significant struggles that those that came before us experienced in the not so distant past, but it had a powerful impact on food culture in the West, particularly the idea that it is better to eat too much than too little. In our elementary education and beyond, we are confronted with story after story of mass famine, and it seems that part of the way that we culturally appreciate our current abundance is by partaking in it.

This appreciation for our abundance has led directly to a culture of overeating that borders on obsession. In the West, we simply love our food too much, and the expansion of cuisine in the West has allowed anyone to get whatever they want, when they want it, whether they go to the grocery store, the pizza parlor, or the Chinese buffet.

A Culture of Overeating Develops into a Culture of Force Feeding

Throughout the twentieth century, we have always been taught that we need to eat every last bite on our plates. Often times, we were also strongly encouraged, if not forced, to go back for a second portion. In addition to this, the proliferation of soda drinks has led directly to a significant increase in the empty calories that the average American consumes.

As the twentieth century barreled on, parents on average had less time to cook and prepare meals at home, which led to the greater proliferation of both fast food and microwavable dinners, loaded with sugars, salts, and carbohydrates which increased our caloric consumption even more!

During this age, restaurants like Burger King and McDonald’s became the captains of the fast food industry, generating billions of dollars in profit funneling cheap calories into the mouths of men, women, and children all across the country.

Because of all these pressures to overeat, the longevity gains that people in the West experienced as a result of modernization all began to slip away, the combination of unhealthy eating and an increasingly sedentary lifestyle is threatening today’s generation with the prospect of living shorter lives than their parents on average!

The United States would be stronger in every way, if it could foster greater consciousness about the importance of eating smarter to eat longer. If we all just made the proactive decision to engage in a lifestyle of at least mild caloric restriction, it would both decrease the price of health care and allow the citizens of this nation to live longer, happier, and healthier lives.

Do You Dream of a Healthier, Happier Life? Contact the Conscious Evolution Institute Today!

If you are a man or woman over the age of thirty and currently live in the United States, the Conscious Evolution Institute can help you improve your health and longevity. We provide Doctor-Monitored Bio-Identical Hormone Replacement Therapy to patients all across the United States.

With just a simple phone call, we can arrange for you to meet with one of our affiliate physicians in order to set you on the road to a new you. We offer a variety of Hormone Replacement options, including Testosterone Replacement Therapy, Human Growth Hormone Injections, Sermorelin Acetate Injections, and HCG Injection Therapy for Weight Loss.

We also provide nutrition and lifestyle counseling in order to help you maximize the results of your treatment by choosing foods, supplements, and exercises that will get your body running on all cylinders!

If you feel that you may be a candidate for Hormone Replacement Therapy, don’t hesitate, call us today, and one of our friendly specialists will walk you through the process and answer any and all questions that you may have.

Recommendation and review posted by G. Smith

biotechnology | Definition, Examples, & Applications …

Posted: May 23, 2018 at 1:45 pm

Biotechnology, the use of biology to solve problems and make useful products. The most prominent area of biotechnology is the production of therapeutic proteins and other drugs through genetic engineering.

People have been harnessing biological processes to improve their quality of life for some 10,000 years, beginning with the first agricultural communities. Approximately 6,000 years ago, humans began to tap the biological processes of microorganisms in order to make bread, alcoholic beverages, and cheese and to preserve dairy products. But such processes are not what is meant today by biotechnology, a term first widely applied to the molecular and cellular technologies that began to emerge in the 1960s and 70s. A fledgling biotech industry began to coalesce in the mid- to late 1970s, led by Genentech, a pharmaceutical company established in 1976 by Robert A. Swanson and Herbert W. Boyer to commercialize the recombinant DNA technology pioneered by Boyer and Stanley N. Cohen. Early companies such as Genentech, Amgen, Biogen, Cetus, and Genex began by manufacturing genetically engineered substances primarily for medical and environmental uses.

For more than a decade, the biotechnology industry was dominated by recombinant DNA technology, or genetic engineering. This technique consists of splicing the gene for a useful protein (often a human protein) into production cellssuch as yeast, bacteria, or mammalian cells in culturewhich then begin to produce the protein in volume. In the process of splicing a gene into a production cell, a new organism is created. At first, biotechnology investors and researchers were uncertain about whether the courts would permit them to acquire patents on organisms; after all, patents were not allowed on new organisms that happened to be discovered and identified in nature. But, in 1980, the U.S. Supreme Court, in the case of Diamond v. Chakrabarty, resolved the matter by ruling that a live human-made microorganism is patentable subject matter. This decision spawned a wave of new biotechnology firms and the infant industrys first investment boom. In 1982 recombinant insulin became the first product made through genetic engineering to secure approval from the U.S. Food and Drug Administration (FDA). Since then, dozens of genetically engineered protein medications have been commercialized around the world, including recombinant versions of growth hormone, clotting factors, proteins for stimulating the production of red and white blood cells, interferons, and clot-dissolving agents.

In the early years, the main achievement of biotechnology was the ability to produce naturally occurring therapeutic molecules in larger quantities than could be derived from conventional sources such as plasma, animal organs, and human cadavers. Recombinant proteins are also less likely to be contaminated with pathogens or to provoke allergic reactions. Today, biotechnology researchers seek to discover the root molecular causes of disease and to intervene precisely at that level. Sometimes this means producing therapeutic proteins that augment the bodys own supplies or that make up for genetic deficiencies, as in the first generation of biotech medications. (Gene therapyinsertion of genes encoding a needed protein into a patients body or cellsis a related approach.) But the biotechnology industry has also expanded its research into the development of traditional pharmaceuticals and monoclonal antibodies that stop the progress of a disease. Such steps are uncovered through painstaking study of genes (genomics), the proteins that they encode (proteomics), and the larger biological pathways in which they act.

In addition to the tools mentioned above, biotechnology also involves merging biological information with computer technology (bioinformatics), exploring the use of microscopic equipment that can enter the human body (nanotechnology), and possibly applying techniques of stem cell research and cloning to replace dead or defective cells and tissues (regenerative medicine). Companies and academic laboratories integrate these disparate technologies in an effort to analyze downward into molecules and also to synthesize upward from molecular biology toward chemical pathways, tissues, and organs.

In addition to being used in health care, biotechnology has proved helpful in refining industrial processes through the discovery and production of biological enzymes that spark chemical reactions (catalysts); for environmental cleanup, with enzymes that digest contaminants into harmless chemicals and then die after consuming the available food supply; and in agricultural production through genetic engineering.

Agricultural applications of biotechnology have proved the most controversial. Some activists and consumer groups have called for bans on genetically modified organisms (GMOs) or for labeling laws to inform consumers of the growing presence of GMOs in the food supply. In the United States, the introduction of GMOs into agriculture began in 1993, when the FDA approved bovine somatotropin (BST), a growth hormone that boosts milk production in dairy cows. The next year, the FDA approved the first genetically modified whole food, a tomato engineered for a longer shelf life. Since then, regulatory approval in the United States, Europe, and elsewhere has been won by dozens of agricultural GMOs, including crops that produce their own pesticides and crops that survive the application of specific herbicides used to kill weeds. Studies by the United Nations, the U.S. National Academy of Sciences, the European Union, the American Medical Association, U.S. regulatory agencies, and other organizations have found GMO foods to be safe, but skeptics contend that it is still too early to judge the long-term health and ecological effects of such crops. In the late 20th and early 21st centuries, the land area planted in genetically modified crops increased dramatically, from 1.7 million hectares (4.2 million acres) in 1996 to 160 million hectares (395 million acres) by 2011.

Overall, the revenues of U.S. and European biotechnology industries roughly doubled over the five-year period from 1996 through 2000. Rapid growth continued into the 21st century, fueled by the introduction of new products, particularly in health care.

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biotechnology | Definition, Examples, & Applications …

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Stem Cell Therapy – Cendant Stem Cell Center – Denver …

Posted: May 23, 2018 at 1:43 pm

Harnessing stem cells to cure disease is the hottest topic in joint injury, knee pain and arthritis treatment today. By using the adult stem cells found in our own bodies, we can amplify and speed up the natural healing process as well as grow new bone and cartilage to rebuild joints without the need for artificial replacements.

At Cendant Stem Cell Centerin Denver and our new Milwaukee Wisconsin clinic, we provide our patients with the most recent technological advancements available for treating orthopedic injuries and conditions. Our Stem Cell therapy procedureprovides treatment to repair damaged cartilage, restore function, eliminate hip, shoulder, back and knee pain and to prevent further joint destruction.

The patients adipose (fat) derived Stem Cells and/or bone marrow derived Stem Cells are injected alongwith Platelet Rich Plasma into the joint capsule space. These components are put on top of an Extracellular Fiber Matrixwhich is injected into the joint capsule before the introduction of Stem Cells. This FDA approved fiberis a major advancement in the Stem Cell procedure which gives Stem Cells a structure to bind and growupon inside the joint space. The technology allows us to treat older patients and patients with more aggressive joint disease who are facing replacement surgery or suffering from chronic pain.

The Stem Cell procedureis virtually painless, takes 3 hours and is performed under local anesthesia. It requires little to no downtime and is effective, fast and safe. Please visit our Video Testimonials page to hear from our patients and why they choose our Denver and Milwaukee stem cell clinics for their medical needs.

Ourunique approach to stem cell therapy does not offer a single franchised solution. Cendants multiple technologies provide case-driven stem cell treatment options to address individual patient needs.

Medical researchers are reporting remarkable results using platelet rich plasma and stem cellsin the treatment of common injuries, including:

What should patients expect after Stem Cell Therapy?

The noticeable regeneration of the joint tissue and cartilage typically starts to occur within 3 weeks. Most of our patients report asubstantialreduction in pain and improved function within 4-6 weeksafter treatment. Many report total pain elimination within 10-12 weeks. Within 3-5 daysafter the procedure, most patients can return to work and resume normal daily activities. Patients cannot start stressful activity or begin strenuous exercise for six weeks. Returning to stressful activity before six weeks may result in incomplete healing of the treated tissue.

Is this therapy safe?

Yes. Autologous PRP therapy and Stem Cell therapy has been used for over 10 years in surgical and orthopedic procedures. There are many research articles published on the safety of these therapies. Because a patients own blood and cells are used, there is little risk of a transmissible infection, no side effects and a very low risk of allergic reaction.

How many treatments are required?

We treat most patients aggressively upon the first visit with a mix of PRP, Extracellular Fiber Matrix and Stem Cells which all work together to create yourregenerative injection. Most patients need only 1 treatment but you could potentially have a follow up pure PRP injection which is thought of as a booster shot, the primary function of which is to stimulate continual stem cell growth.

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Stem Cell Therapy – Cendant Stem Cell Center – Denver …

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Pet Stem Cell Therapy | Safari Veterinary Care Centers in …

Posted: May 22, 2018 at 6:44 am

Applying regenerative cells from your pets own healthy tissue directly to the site of an injury helps the body heal itself by secreting growth factors, reducing inflammation, modulating the immune system and regenerating injured tissue in a potent but natural way. This holistic process can be used in addition to or as an alternative to chronic drug therapy or surgery saving 1000s of dollars over your pets life.

Fat tissue is obtained from your pet in an in-clinic procedure, and regenerative cells (including stem cells) are prepared for re-injection in about 90 minutes. Initial results may be evident as early as the 1st week.

Regenerative cells promote healing and regeneration of injured or damaged tissue. Stem cells are regenerative cells that can differentiate into multiple cell types to form new functional tissue. These cells, located in your pets fat stores can be harvested, separated from the fat and stimulated to revert to an active reparative state. Regenerative cells may also secrete factors that reduce autoimmune responses and inflammation, promote cell survival, and stimulate tissue regeneration.

Our system providers; InGeneron and Medivet Biologics have been conducting research for years on the use of autologous adult stem cells in regenerative medicine. InGenerons team of scientists and clinicians have published more than 40 peer-reviewed studies in collaboration with renowned academic facilities such as M.D. Anderson Cancer Center and Tulane University. Medivet is currently conducting research on stem cell therapy for osteoarthritis at Kansas State University, and Cartilage Regeneration and osteoarthritis at the University of Georgia.

Unlike other cell therapy procedures, both the InGeneron and MediVet systems enable isolation and treatment within the same day processed at the Safari Stem Cell Laboratory assuring high quality and quantity of cells.

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Pet Stem Cell Therapy | Safari Veterinary Care Centers in …

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April 16: Pharmacogenomics – National Human Genome …

Posted: May 22, 2018 at 6:41 am

PharmacogenomicsChoosing the right medication at the right dose for each patient

April 16, 2018

Did you know … that the sequence of your genome can determine how you respond to certain medications?

Understanding pharmacogenomics, or tailoring a person’s medications based on their genome, would not be possible without sequencing the genomes of many people and comparing their responses to medicines.

Oneof the most important uses for DNA sequencing is not to just sequence one human genome – but rather to sequence many human genomes to understand how genomic differences relate to different traits. Some such traits reflect physical characteristics (like eye color), whereas others can be used to help in the clinical care of patients. Scientists in the field of pharmacogenomics study how specific variants in your genome sequence influence your response to medications.

In order for our bodies to use some medicines properly, the cells in our bodies must make a few chemical changes that convert them into an active form, just like we do when we eat food. Then, these active forms of the medicine must get to the right places in the body or inside cells to do the job that we want them to do. If we want to make sure this happens, it makes sense that we would target our bodies’ pathways involved in changing the medicine’s form or in getting medicines to the right places. For example, you probably know someone who takes an antidepressant. Many of these medicines get to the right places by interacting with a protein called ABCB1,which works like a traffic cop on the outside of your cells.

Given ABCB1’s important role in controlling traffic, you might imagine that if someone has a genomic variant that changes the shape or function of their ABCB1 protein, they might have a different response than usual to any number of medicines. We now know that is the case for some antidepressants, as well as other medications like statins for cholesterol and certain chemotherapy medicines. As a result, there are at least 18 pharmacogenomic tests for variants in ABCB1 listed in the NIH’s Genetic Test Registry, with suggestions that you be tested for these variants to help determine the correct dose for certain medications.

Video courtesy of Mayo Clinic

Healthcare professionals and researchers are constantly seeking both to optimize medical treatments and to avoid adverse (or negative) reactions to treatments, which are estimated to affect between 7 percentand 14 percentof hospitalized patients. This makes adverse reactions a large cause of added days spent in a hospital, and the fourth leading cause of death in the United States.

One scary example of such an adverse reaction is Stevens-Johnson syndrome (SJS), a severe allergic reaction also called “scalded skin syndrome.” It can be caused by infections, but also by very common medications like ibuprofen, anti-seizure medicines, or antibiotics. Patients may go from taking two pain pills to ending up in the hospital burn unit fighting for their lives if SJS progresses to a worse condition called toxic epidermal necrolysis (TEN). TEN is diagnosed when patients have shed at least one-third of the skin off of their bodies. Needless to say, anything we can do to prevent this allergic reaction is vitally important.

In Taiwan, married scientists Wen-Hung Chung (a physician) and Shuen-Iu Hung (an immunologist) noticed that SJS/TEN was much more common in patients taking carbamazepine, used to treat epilepsy and seizures, or allopurinol, used to treat gout. They showed that this was due to genomic variants in the HLA-B gene. Not surprisingly, this gene helps control the immune response. As a result of their work, the country of Thailand has implemented genomic testing before these medications are prescribed. The results of this “pharmacogenomic test” are used to decide whether it is safe to give a specific patient certain medicines, like carbamazepine or allopurinol. Thailand’s government even covers the cost of this testing, and the frequency of SJS/TEN has been drastically reduced. We have since learned that different ancestries are associated with different HLA-B genomic variants, so countries may need to take different approaches to monitor which medications are most likely to be linked to SJS/TEN.

Video courtesy of Mayo Clinic

Understanding pharmacogenomics would not be possible without sequencing the genomes of many people and comparing them, and then comparing their response to medicines. But we have also learned that a person’s genome sequence is not everything when it comes to medication responses. The human body is a very complicated machine, and the instructions written in our DNA are just part of the process.

There are some cases, as with the breast cancer treatment tamoxifen, where a small study showed that there might be a relationship between someone’s response to the medicine and a variant in the CYP2D6 gene. However, this finding did not appear to be true in a larger study that involved many more people. That’s why at this time, the U.S. Food and Drug Administration (FDA) labeling for tamoxifen does not recommend CYP2D6 pharmacogenomic testing, but the issue is still being reviewed as more research is conducted.

Another gene in the same CYP family, called CYP2C19, has variations which affect how your body can use clopidogrel (more commonly known as Plavix). This medication is a “blood thinner” which helps prevent blood clots, and thus reduces your risk of strokes or some heart attacks. If your CYP2C19 protein is not working properly due to a mutation in the gene, then you will not be able to process clopidogrel, and you need either a different dose or a different medication. As it turns out, these variants in CYP2C19 are also more common in those with Asian ancestry. Although testing for variants in this gene is also not routinely recommended, you may wish to speak with your healthcare provider about the test if you are given a prescription for clopidogrel, particularly if you have East Asian family members.

As the field of pharmacogenomics develops, more and more clinical trials will test for interactions between our genomes and the medicines we take. If you are interested in participating in such trials, you can search the ClinicalTrials.gov registry and look for ongoing studies with your condition. If you are curious whether any of your medications are known to be associated with pharmacogenomic information, check out the Pharmacogenomics Knowledge Database and speak with your medical care team. And, if you’d like to be part of a national effort along with one million other people that will involve pharmacogenomics research, look into the National Institute of Health’s All of Us program.

Posted: April 16, 2018

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April 16: Pharmacogenomics – National Human Genome …

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Antisense therapy – Wikipedia

Posted: May 16, 2018 at 7:42 am

Antisense therapy is a form of treatment for genetic disorders or infections. When the genetic sequence of a particular gene is known to be causative of a particular disease, it is possible to synthesize a strand of nucleic acid (DNA, RNA or a chemical analogue) that will bind to the messenger RNA (mRNA) produced by that gene and inactivate it, effectively turning that gene “off”. This is because mRNA has to be single stranded for it to be translated. Alternatively, the strand might be targeted to bind a splicing site on pre-mRNA and modify the exon content of an mRNA.[1]

This synthesized nucleic acid is termed an “anti-sense” oligonucleotide (AON) because its base sequence is complementary to the gene’s messenger RNA (mRNA), which is called the “sense” sequence (so that a sense segment of mRNA ” 5′-AAGGUC-3′ ” would be blocked by the anti-sense mRNA segment ” 3′-UUCCAG-5′ “).

Antisense oligonucleotides have been researched as potential drugs[2][3][4] for diseases such as cancers (including lung cancer, colorectal carcinoma, pancreatic carcinoma, malignant glioma and malignant melanoma), diabetes, amyotrophic lateral sclerosis (ALS), Duchenne muscular dystrophy, spinal muscular atrophy, Ataxia-telangiectasia and diseases such as asthma, arthritis and pouchitis with an inflammatory component. As of 2016, several antisense drugs have been approved by the U.S. Food and Drug Administration (FDA): fomivirsen as a treatment for cytomegalovirus retinitis, mipomersen for homozygous familial hypercholesterolemia, eteplirsen for Duchenne muscular dystrophy, and nusinersen for spinal muscular atrophy.

As of 2012, some 40 antisense oligonucleotides and siRNAs were in clinical trials, including over 20 in advanced clinical trials (Phase II or III).[5][6]

Also in 2006, German physicians reported on a dose-escalation study for the compound AP 12009 (a phosphorothioate antisense oligodeoxynucleotide specific for the mRNA of human transforming growth factor TGF-beta2) in patients with high grade gliomas. At the time of the report, the median overall survival had not been obtained and the authors hinted at a potential cure.[7]

Fomivirsen (marketed as Vitravene), was approved by the U.S. FDA in Aug 1998 as a treatment for cytomegalovirus retinitis.

In January 2013 mipomersen (marketed as Kynamro) was approved by the FDA for the treatment of homozygous familial hypercholesterolemia.[8][9]

In early 2006, scientists studying the Ebola hemorrhagic fever virus at USAMRIID announced a 75% recovery rate after infecting four rhesus monkeys and then treating them with an antisense Morpholino drug developed by Sarepta Therapeutics (formerly named AVI BioPharma), a U.S. biotechnology firm.[10] The usual mortality rate for monkeys infected with Ebola virus is 100%. In late 2008, AVI BioPharma successfully filed Investigational New Drug (IND) applications with the FDA for its two lead products for Marburg and Ebola viruses. These drugs, AVI-6002[11] and AVI-6003 are novel analogs based on AVI’s PMO antisense chemistry in which anti-viral potency is enhanced by the addition of positively charged components to the morpholino oligomer chain. Preclinical results of AVI-6002 and AVI-6003 demonstrated reproducible and high rates of survival in non-human primates challenged with a lethal infection of the Ebola and Marburg viruses, respectively.[12]

Starting in 2004, researchers in the US have been conducting research on using antisense technology to combat HIV.[13]

In February 2010 researchers reported success in reducing HIV viral load using patient T-cells which had been harvested, modified with an RNA antisense strand to the HIV viral envelope protein, and re-infused into the patient during a planned lapse in retroviral drug therapy.[14]

In 2004, development of an antisense therapy for spinal muscular atrophy was started. Over the following years, an antisense oligonucleotide later named nusinersen was developed by Ionis Pharmaceuticals under a licensing agreement with Biogen. In December 2016, nusinersen received regulatory approval from FDA for use to treat spinal muscular atrophy.[15][16]

In September 2016, eteplirsen received FDA approval for the treatment of Duchenne muscular dystrophy.

Volanesorsen is in phase 3 clinical trials for treating hypertriglyceridemia as of December 2016.

Because nucleases that cleave the phosphodiester linkage in DNA are expressed in almost every cell, unmodified DNA molecules are generally degraded before they reach their targets. Therefore, antisense drug candidate molecules are generally modified during the drug discovery phase of their development.[17][18] Additionally, most targets of antisense are located inside cells, and getting nucleic acids across cell membranes is also difficult. Therefore, most clinical candidates have modified DNA “backbones”, or the nucleobase or sugar moieties of the nucleotides are altered. Additionally, other molecules may be conjugated to antisense molecules in order to improve their ability to target certain cells or to cross barriers like cell membranes or the blood brain barrier.[17]

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Antisense therapy – Wikipedia

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23 People That Lived to 100 Spill Their Secrets of Longevity

Posted: May 14, 2018 at 7:43 pm

Ever since I was a kid, I was always curious about the secrets to longevity and what made people live to 100. I mean, 100 is kind of a random number, but triple digits?! Thats pretty amazing there must be some kind of secret. Seeing as you usually hear that peoples grandparents die in their 70s or 80s I was totally intrigued by these long-lived peeps.

My great grandma, who I knew until I was about 10 years old, lived to her later 90s, 97 or 98 and I was still hanging out with her at that age talking about life. Unfortunately since I was so young, the only thing I remember was how creepy she was. She was really small. Really thin. And really veiny.

Anyway, as I got older I became more interested in longevity not because I actually wanted to live to 120, but because the kinds of people that live to 120 are the ones who usually enjoy an unprecedented quality of life throughout their lives.

The people who take good enough care of themselves to live to that ripe, old age, also suffer from a fraction (or none) of the health problems that plague the majority of people today.

Interestingly enough, as I researched the secrets to their longevity I found much of the same advice, over and over.

You can find that advice below.

Exclusive Bonus: Download this bonus guidethat tells the story of how a Chinese herbalist lived to 200+ and his 4 pieces of advice.

The Biomat is a product that can help with natural pain relief.

Based on her Wikipedia entry, at age 85, she took up fencing and continued to ride her bicycle up until her 100th birthday. She was reportedly neither athletic, nor fanatical about her health.

Calment lived on her own until shortly before her 110th birthday, when it was decided that she needed to be moved to a nursing home after a cooking accident (she was having complications with sight) started a small fire in her house.

Calment smoked from the age of 21 to 117, though according to an unspecified source, she smoked no more than two cigarettes per day. (Damn babygirl you smoked for 100 years?!)

Calment ascribed her longevity and relatively youthful appearance for her age to olive oil, which she said she poured on all her food and rubbed onto her skin, as well as a diet of port wine, and ate nearly one kilogram (2.2lb) of chocolate every week.

Not a bad life, eh? Smoke, drink and eat chocolate.

Based on biographical information via Wikipedia:

Her only child, Kathryn Knauss Sullivan, who was 96 at the time of Sarahs death and lived to be 101 herself, once explained Knauss longevity by saying: Shes a very tranquil person and nothing fazes her. Thats why shes living this long.

On his 115th birthday Mortensen gave his advice for a long life: Friends, a good cigar, drinking lots of good water, no alcohol, staying positive and lots of singing will keep you alive for a long time.

He credited his longevity to funche, a boiled corn, codfish and milk cream-like dish, which he ate every day as a habit. Mercado also claimed that his sense of humor was probably responsible for his long life, and he would tell jokes and humorous anecdotes almost to the end of his days.

He would not elaborate on details of his love life, but would humorously hint about them: in one of the many interviews he gave to Puerto Rican media, Mercado claimed to have been at the dancing club (a euphemism for a bordello) owned by Isabel la Negra the day she was assassinated.

He was 82 years old at the time and reportedly hid under a table when Oppenheimers killers started firing gunshots. Asked what he was doing there, he said: praying or at least I was when the bullets started flying!

Mind your own business and dont eat junk food. Treat everyone the way you want to be treated, work hard and love what you do.

Laughter keeps you healthy. You can survive by seeing the humor in everything. Thumb your nose at sadness; turn the tables on tragedy. You cant laugh and be angry, you cant laugh and feel sad, you cant laugh and feel envious.

Do the right thing, dont smoke, dont drink, eat right and dont overdo it. If you need a little extra help, take some vitamins. Going to work is what keeps me going.

Look inside your soul and nd your tools. We all have tools and have to live with the help of them. I have two tools, my words and my images. I used my typewriter, computer and my cameras to ght injustice. Whenever I see a possibility of helping people who are in danger, I want to help them.

Eat right and do what you love. Whatever you love to do is play; doing what you dont like to do is work. I have never worked a day in my life!

Have a good appetite, lots of friends, and keep busy.

Stay active even at 100. Eat in a balanced way Dont stay mad at anythingyou have to get used to the losses, otherwise you cant win. Lastly, stay close with your family, they keep you thinking.

Have a good wife, two scotches a night, and be easy-going.

It is very important to have a widespread curiosity about life.

Take it easy, enjoy life, what will be will be. Sleep well, have a Baileys Irish Cream before bed if you have a coldyou will wake up ne the next morning.

Dont smoke, dont drink, and dont retire!

Take one day at a time and go along with the tide.

Keep busy! Do things that youve never done before.

Dont ght the day, just let it be. Get up and be positive. Avoid any and all drama; I dont get involved with silly minutiae or difcult personalities; people respect me for that.

Be good, dont complain, just get up and do. Keep on working, keep on going, and have a good time.

Get involved. Youll nd pleasure and sometimes disappointment but there is a sense of achievement if you participate in a successful undertaking, whether it is organizational or professional. Work hard, it will pay off.

Whatever is hard, you make hard, but if you take it as it comes, it doesnt come hard. Dont worry, dont want so much, and be satisfied with what youve got. Be willing to share with your friends and those less fortunate.

You must keep active or you will just wither away. Always be involved in some activity.

You have to make the best out of your life and have a good attitude.

When you live for God, talk to him, go to church, have nice people around you; that is the best medicine. God provides for you. Sometimes you dont know when it is coming, but it is coming.

Try to understand the kind of person you are and accept who you are; but if you want to improve your situation, change it. Keep your eye on the stars and try to succeed at what you want to do.

For a long, healthy life, you need a plan and a purpose. It could be family, writing a book, becoming president. Without a purpose, plan or objective, what do you need?

Never run out of responsibility; if you dont have one, nd one. Find a cause and knock yourself out for it. It will enhance your brainpower, interest in life, and keep you alive longer. Im alert because I work. Virtue is its own reward.

My longevity is attributed to my long happy marriage. We did everything together. She was perfect in my eyes.

You know whats cool?

There are definitely a few things repeated over and over.

I went back through the list and wrote down the top 5 things that appeared the most frequently. Do you know what they were?

The most commonly cited things:

[See Also: A 256 Year Old Man Reveals His 4 Secrets to His Longevity]

I think that many of us intuitively know some of the things that contribute to a long life, like relaxing and enjoying life, keeping your mind busy, and obviously eating right and exercising.

One of the craziest things Ive come across in the past few years is that some people have willed themselves to death. In extreme survival situations, people have been found in safe, secure places, with food and water, who simply gave up. Sometimes there was a journal, but other times these people had no verifiable medical reason for their death. They just didnt want to fight.

The external is seriously overrated in our society people seem to neglect the power of the mind to make a person happy or miserable, successful or unsuccessful, lazy or driven.

The oldest woman in the world smoked every day for almost 100 years. Was she lucky? Maybe.

But listen to all of these people talk they just freaking love life. A good cigar, a glass of wine, some chocolate, and good friends. Theyre living the good life no wonder they want to go on living.

So what about you? Do you know anyone who lived to a ripe-old age? What do you think contributed to it?

Alex

***

Sources: Some adapted from the book Extraordinary Centenarians in America.

Other quotes were compiled from interviews listed in Wikipedia.

Images: Indian Man, Countryside, Empire State Building, Puzzle, Bridge, Sunset, Ice & Sunset, Green Vegetable, Desert

Continue reading here:
23 People That Lived to 100 Spill Their Secrets of Longevity

Recommendation and review posted by G. Smith


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