The Future Of Nano Technology
- Alan Watts
- Anti-Aging Medicine
- David Sinclair
- Gene Medicine
- Gene therapy
- Genetic Medicine
- Genetic Therapy
- Hormone Replacement Therapy
- Human Genetic Engineering
- Human Reproduction
- Integrative Medicine
- Life Skills
- Longevity Medicine
- Machine Learning
- Medical School
- Nano Medicine
- Parkinson's disease
- Quantum Computing
- Regenerative Medicine
- Stem Cell Therapy
- Stem Cells
- Rigenerand receives regulatory approval for gene therapy production – Cleanroom Technology
- Scientists Find A Switch To Turn Off A Gene That Causes Aggressive Breast Cancer – Forbes
- Why Editas Medicine Is Now the CRISPR Stock to Really Watch – Motley Fool
- Research Roundup: How Tau Proteins Spread in Alzheimer’s and More – BioSpace
- The Boy Slumped to the Floor. Could These Be Seizures? – The New York Times
|Search Immortality Topics:|
Category Archives: David Sinclair
A selfish neighbour breached her Asbo by inviting friends round for an illicit party during the coronavirus lockdown.
Shannon Mullen, 25, was caught with more people in her home than she was allowed under the strict terms of her anti-social behaviour order.
Mullen who had made her neighbours lives a misery broke the Asbo by having more than two people in her home on May 10.
Dundee Sheriff Court was told that Mullen had the Asbo imposed on March 25 after a series of incidents at the property in Burns Begg Street, Kinross.
Depute fiscal Lisa Marshall told the court: She has previous convictions. She has been making her neighbours lives a misery.
Mullen was banned from shouting, swearing, screaming, slamming doors, arguing, fighting, banging walls and playing loud music under the terms of the interim order.
It also prevented her from having others banging the external door and shouting and swearing at the property.
But it was the condition limiting her visitor numbers which she admitted breaking by having three people in the house during the pandemic lockdown.
Solicitor David Sinclair, defending, said: Things have been difficult with her neighbour. I am not sufficiently familiar with the case to know whats caused that.
She accepts there were three persons in her house. Her intention is to go to Kelty and live with her mother, which may give her neighbours some respite.
Mullen, now of Croftangry Road, Kelty, had sentence deferred and was ordered to be of good behaviour for six months.
Up until now, research into the demographics of drug use has focused more on age, finding that midlife is the riskiest time for drug-related death, but Burke and colleagues saw that the year a person was born also has a large effect.
These phases map onto the previously identified drug waves that came with the waxing and waning popularity of prescription opioids, heroin and fentanyl, each in turn.
Peering within each generation, Jalal and colleagues saw a steady march toward greater overdose risk at younger ages for each successive birth year, which they found quite surprising.
Theres no reason why the lines should be fanning like this, Jalal said. If you look at breast cancer, for example, or any other mortality curves, they dont look like that.
Its not clear why this is happening, Jalal said, but the pattern is too clean to chalk up to chance. And an overall rise in drug overdose deathsalthough that is happening in the background of these datadoes not explain away the results presented in this study.
Burke uses an analogy borrowed from infectious diseases to explain the progressive shift of drug overdose deaths to younger ages.
Burke hopes that the highly regular patterns uncovered in this analysis will give policy makers a tool for testing whether their measures to curb drug overdose deaths are working over the long termany effective intervention should disrupt the pattern.
Additional authors on the study are Jeanine Buchanich, David Sinclair and Mark Roberts, all of Pitt Public Health. Funding was provided by theNational Center for Advancing Translational Sciencesand theRobert Wood Johnson Foundation.
See the original post:
Drug Use is Transmitted from Old to Young - UPJ Athletics
The Mayfair restaurant and wine boutique invite diners to a virtual four-course dinner with head sommelier Julien Sarrasin
Guests of Mayfair restaurant Hide can now enjoy a four-course menu prepared by Ollie Dabbous and paired with fine wines from Hedonism all in the comfort of their own home.
The Michelin-starred restaurant and its sister wine merchant Hedonism have upped the ante in the high-end food delivery stakes by offering diners the chance to join HIDE at HOMEs head sommelier Julien Sarrasin by live video feed on Wednesday 13th May.
Sarrasin will introduce each dish and discuss each of the wines in turn. Diners will learn about the winemaker, the grape varieties and why each fine wine was selected to pair with a particular course.
The menu starts with a chilled pine broth amuse bouche with strawberries, avocado, basil and pistachio. The starter is scallop tartare with Exmoor caviar, followed by Champagne-poached cornfed chicken, sptzle and black truffle. Dessert is a baked Alaska made with cascara, coffee and pecan.
Wines will be delivered one or two days before the date of the event. The meal will be delivered on the evening of Wednesday 13th May. The offer is limited to a list of London postcodes which is available on the HIDE at HOME site.
The menu will be prepared by Ollie Dabbous and his team at Hide. The chef opened his first restaurant, Dabbous, in 2012 and earned his first Michelin star. After closing Dabbous in 2017, the chef joined forces with Hedonism Wines to launch Hide, which earned a Michelin star within six months of opening in 2018.
The virtual wine dinner from HIDE at HOME is just one in a series of virtual events being run by the restaurant. Others include a spirit tasting to discover the smoky drams of Scotland with specialist Tom Olive, a winemaker tasting with the Chef de Cave at Charles Heidsieck, Cyril Brun, and a whisky tasting with The Macallans owner David Sinclair.
Prince William County will leave the rate on real estate taxes unchanged for the next fiscal year, as the budget reality of the COVID-19 pandemic forced supervisors to ditch new spending and a proposed tax rate increase.
More than 25 Prince William County residents who talked remotely to the board of county supervisors Tuesday were divided with many supporting a proposal to keep the real estate tax rate steady in an effort to fund schools and social services, while others said the county should decrease the tax rate as thousands in the county have lost jobs and others face furloughs and an uncertain future amid the COVID-19 pandemic.
The board adopted its $1.09 billion budget for fiscal year 2021 that starts July 1.
The board adopted the same real estate tax rate as this fiscal year: $1.125 for every $100 of assessed value. That doesnt mean that taxes wont go up. Residents who have seen property values climb will see an increase in their tax bill, about a $177 increase on the average residential tax bill.
The vote was 5-3. Supervisors Jeanine Lawson, R-Brentsville, Pete Candland, R-Gainesville, and Yesli Vega, R-Coles, argued for a tax rate of $1.085 per every $100 of value. Democratic supervisors argued the cuts would limit county services.
Supervisors also voted to increase the tax rate on computer equipment by 10 cents to $1.35 per every $100 of assessed value a charge that primarily affects data centers.
The adopted budget has $40.6 million less than staff had proposed on Feb. 18. Of that money, $22.7 million was expected to be added to school division revenue.
The board ended up allocating $629.6 million to the division, including $625.3 million that is part of the countys revenue sharing agreement, along with additional funding for class size reduction, costs related to the 13th high school and more.
Chair Ann Wheeler said she expects the board will have to revisit its budget every quarter due to the uncertainty of the pandemic.
When the board adopted its current budget last year, Republicans held a 6-2 majority. Now, Democrats hold a 5-3 majority.
The budget included $7 million for pay increases for about 1,500 employees, raises that were recommended to the board to ensure employees are being paid equally for similar work and to make sure pay is competitive with other governments in the region.
Supervisor Andrea Baileys proposal to add an additional $150,000 for community partners nonprofits such as ACTS in Dumfries to the existing proposal of $92,904 for fiscal year 2021 was also approved.
David Sinclair, the countys director of the office of management and budget, told the board the fiscal 2021 budget means about $36 million less than the school board adopted as part of its recommended budget. The school board is waiting to adjust its spending plan until after the county and the state determine how deep cuts will go.
On Feb. 18, County Executive Christopher Martino proposed a budget based on a 2-cent increase to the real estate tax rate. After the coronavirus, Wheeler sought a budget that kept the tax rate unchanged.
Among items cut was a 3% merit raise for county staff. Martino also has implemented a hiring freeze unless the position is required for public safety related to the pandemic, focused spending on core services, and postponed large construction projects that are not under contract, among other measures.
Staff project the county will see $14.2 million less in revenue in fiscal year 2021. The county also expects to receive $2.4 million less in revenue prior to June 30, when fiscal 2020 ends.
In Prince William Health District, which includes the county, Manassas and Manassas Park, reported 1,677 people who tested positive for COVID-19, 183 people were hospitalized and 23 people have died due to the virus, according to the Virginia Department of Health.
According to the Virginia Employment Commission, over 28,600 Prince William residents filed for unemployment benefits between March 15 and April 18.
The board also approved the request from Supervisor Andrea Bailey, D-Potomac, for $2 million for the environmental and preliminary design for the Van Buren Road extension project. That funding is coming from the Northern Virginia Transportation Authority.
Supervisor Margaret Franklin, D-Woodbridge, proposed on April 21 to starta small business program so the county can offer $10,000 loans and grants through its Industrial Development Authority. This week,theboard approved $1 million for that program starting this fiscal year 2020 and carrying over any funds to fiscalyear 2021. Also starting this fiscal year, is a program pitched by Franklin to dedicate $500,000 to offer rental or utility assistance for people who are low income or elderly or disabled.
How many of these myths do you accept as reality?
Myth 1: When it comes down to it, aging is just another disease, asserts professor David Sinclair, PhD, a Harvard professor.
He is convinced that aging, like obesity, is a pathological condition that scientists will eradicate.
Reality: If aging is a disease, it must be highly contagious because all my patients get it, says Dr. Todd Bouchier, a Grass Valley physician. And everyone over the age of 65 has an advanced case.
Support Local JournalismDonate
Humor aside, Dr. Bouchier continues, aging is not a disease. Over time, mountains crumble, barns collapse, and cells degenerate. Aging is a fact of nature. Scientists get excited about the possibility of escaping the preprogrammed aspects of cellular aging. No doubt, well make gains and eventually live longer but wont eliminate aging. Making the final years as meaningful as possible is the goal.
Myth 2: All seniors are alike and are best described as sexless, toothless, prune juice-drinking dribblers who watch daytime television and shuffle like Tim Conway.
Reality: People live more diverse lives over time. People in their 20s are more alike than folks in their 80s. We even age differently. Four distinct ageotypes metabolic, immune, hepatic (liver), and nephrotic (kidney) determine how and where in the body biologic aging occurs.
As for sex, studies show that seniors enjoy sex and variations of sexual activity beyond middle age. Moreover, the need for intimacy touching, hugging, or holding hands is timeless.
Myth 3: Old timers are a drain on society, sucking up resources the younger folks need. The fewer seniors in a community, the healthier it is. The coronavirus can thin the herd.
Reality: Over 1,200 nonprofit and 501(c) organizations operate in Nevada County, enriching our community in immeasurable ways. Funding and volunteer support (estimated at 10,000 hours annually) rely heavily on seniors for these civic and social activities.
Plus, increasing numbers of seniors work. And even those who arent on a payroll still work as grandparents and caregivers.
As for welfare, older people have emerged as the wealthiest segment of our population.
Myth 4: Seniors dont need or buy much, hence, commercials focus on young people, except for depressing pharmaceutical ads.
Reality: The 65-and-older population is the mother of all untapped markets, according to Barrons. In 2015, the spending of Americans ages 50 and up accounted for nearly $8 trillion worth of dollars spent. By 2030, the 55-and-older population will have accounted for half of all domestic consumer spending growth.
And even when household income for older people is at or below the median, they have as much or more disposable income as young people with the same income.
Myth 5: You cant teach an old dog new tricks. Technology is wasted on seniors. Humans are born with a finite number of brain cells that die off with aging.
Reality: Learning patterns may change and the speed of learning may diminish, but the basic capacity to learn is retained. As for technology, in 2000, 14% of those aged 65 and older were internet users; now 73% are.
Moreover, through the process of neurogenesis, brain cells adapt and reconnect even regrow and replenish. Thanks to brain plasticity, we old dogs can teach young dogs some new tricks!
Myth 6: To be old is to be irritable and grumpy. Depression is inevitable given the declining trajectory of deteriorating mental and physical health.
Reality: Depression is not a normal part of aging but rather an illness requiring treatment. The course of depression in the elderly is identical to that of younger persons, and the response to treatment appears as positive as that of people in other life stages.
Myth 7: Senior moments signal the onset of dementia, a disease no one escapes if they live long enough. The lights are still on, but the voltage is low.
Reality: Forgetfulness occurs at all ages, but were more inclined to notice as we age. The good news is that the rate of dementia is declining and occurring at older and older ages. Only 5% of people over age 65 have dementia. In addition, some memory loss is caused by medications and medical conditions unrelated to aging.
The best news is that aging and dementia are not inextricably linked. Evidence is growing that regular exercise, healthful eating, and mentally challenging activities can preserve cognitive functions independent of age.
Accepting these myths holds us back. It cuts us off from opportunities that are jumping up and down in front of us seeking to get our attention. Knowing the truth, on the other hand, sets us free to explore our options while we celebrate the simple joy of being alive.
Next Month: Your body over time
Carole Carson, Nevada City, is an author, former AARP website contributor, and leader of the 1994 Nevada County Meltdown. Contact: email@example.com.
Read more from the original source:
Carole Carson: Adventures in Aging Seven myths about getting older - The Union of Grass Valley
Not yetbut he sure is getting rich, famous, and having a blast while trying.
Portrait by Ken Richardson
Like any dreamer, David Sinclair has a tendency to live in the future. The first time that thought crossed my mind, we were hurtling toward Worcester in his Tesla, on our way to visit one of his many companies working on an antidote to aging. Sinclair told me hed recently discovered, using a health-tracking device, that hes shaved a decade off his life: Biologically speaking, he is now 40, not 50. I took a good look at him. Except for the pillow he sat on while he drove, the wrinkles that formed around his eyes when he flashed his mischievous grin, and the note scrawled on the back of his hand (lest he forget something he has to do), there was no way in hell he looked anywhere near 50. He is slight of build, with nary a gray hair, and bears a passing resemblance to that forever child Alfred E. Neuman. He even says he feels like a kid, too.
I had skipped breakfast that morning to get a feel for what its like to be Sinclair, whose habit of not eating anything until the afternoonalong with ingesting a mysterious medley of pillsis one of his many life-extending practices. When I asked about one of the drugs he takes, he reached into his pocket and pulled out a capsule filled with a white powder that he packages himself in his lab. He has told reporters that the substance inside is a miracle molecule. I plucked it from his hand and put it in my own. It felt so light in my palm. So easy to believe. And that is precisely the problem.
From time immemorial, people have been on a fantastical quest for a substance that would extend life, or even grant immortality. The medieval alchemists sought the elixir of life. Explorer Ponce de Leon looked for the fountain of youth in what is now the southern United States but, in an ironic twist of fate, found Florida, a place where people go to grow old and die. As the centuries wore on, traffic in life-extending substances and practices became the clear bailiwick of snake-oil salesmen, charlatans, and quacks.
More recently, though, longevity has become the stuff of legitimate science. Sinclair is a superstar among a group of researchers who have harnessed science and technologys latest advances in an effort to parse out, for the very first time, the biological mechanisms of aging in hopes of slowing or even reversing the process. The goal of this field is not to make us young for youths sake, but to address the single greatest risk factor for heart disease, cancer, diabetes, dementia, and many other forms of modern-day suffering: aging. This radical new thinking about medicine maintains that if we can address the upstream cause of these diseases, we can cure them all at once (instead of relying on the current Whack-a-Mole approach) and increase the number of years people live with good health. But it is also true, experts say, that eliminating all of these diseases of aging will make people live longer. We are on the verge of a public health breakthrough of the kind we have never seen before, says S. Jay Olshansky, a professor of public health who studies demographics and aging at the University of Illinois at Chicago. It is not trivial. This is bigtime.
Sinclair deserves much of the credit for getting the field to where it is today. The Australian-born Harvard Medical School professor of genetics has had countless discoveries published in the most respected scientific journals in the world and has received dozens of scientific prizes and honors. Last year he was appointed an Officer of the Order of Australia for his contributions to humanity. Wealthy investors, including WeWork cofounder Adam Neumann, have bet hundreds of millions of dollars on his science and invested in the 17 companies hes founded. When Sinclairs book, Lifespan: Why We Ageand Why We Dont Have To, was released in September, it reached number 11 on the New York Times bestseller list in just over a week.
At the same time, Sinclair is one of sciences most controversial figures, regarded by many as a slick salesman who overhypes his work and its potential. Some critics cringe when he speaks of miracle molecules and everlasting life. Others whisper that his science may not be completely sound. Still others roll their eyes over his habit of taking drugs that havent been proven to delay aging in anyone who isnt a mouse. The prevailing wish among his doubters is for him to simply keep his mouth shut. He is a complicated guy, says Steven Austad, a professor of biology who studies aging at the University of Alabama at Birmingham and is a friend of Sinclairs. Hes a superb scientist, as well as a superb salesman. You talk to him about science and you wont find many more knowledgeable, incisive experimentalists as David. And then you can listen to the stuff he says on TV and be like, What the hell is he talking about?
Sinclairs bold statements and pill-popping habits have ruffled feathers closer to home, tooat the very institution that employs him. He does do research and he gets it published in peer-reviewed journals, and if he just did that, itd be fine, says a Harvard Medical School professor who asked to remain anonymous. But then he speaks out about how he makes himself young and says stuff that would be embarrassing for any normal scientist to say.
In other words, in an increasingly legitimate field of science desperate to distance itself from the alchemists and quacks of yore, Sinclair presents somewhat of a problem. As a brilliant scientist in the lab, he is a major asset to his fields eternal quest for legitimacy. Let loose in the world, though, the self-described Star Trek wannabe, whos eager for the future to arrive as fast as possible, is somewhat of a liability. He may very well be the man who will unlock the secret to extending life some 10, 20, or even 30 yearsso long as he doesnt get lost searching for the fountain of youth along the way.
David Sinclair hanging out with Joe Rogan after appearing on his podcast. / Photo from Instagram
Sinclair can remember with startling clarity the day he first learned about death. He was with his beloved grandmother at her home in Turramurra, a leafy suburb of Sydney on the edge of the bush. They were seated on the floor playing when she told him his cat would only live to about 15. He was shocked. And the news only got worse. Everybody dies, she told him.
It is not surprising for children to be disturbed when they learn about mortality, but most of them move on, squirreling away the fear and dread until it comes bubbling back to the surface with the appearance of gray hairs, knee pain, and mental lacunas. Sinclairs trajectory was slightly different. In a sense, he never got over it.
While his biochemist parents worked, Sinclair spent most of his childhood with his fun-loving, free-spirited grandmother, who admonished him to never grow up. By the time he enrolled at the University of New South Wales to study biochemistry, he was convinced that science would one day catch up with his grandmothers ideas and people would be able to stay young forever. He believed, however, that he had been born too early to see it. He told his friends at school over coffee that they were likely to be the last of thousands of generations to live the sad existence of such a short life. But no sooner had he thought it, he says, than he considered the fact that maybe he was wrong. Maybe it could happen in his lifetime, and maybe he could be a part of it. Sinclair had found his lifes purpose.
His next stop was 10,000 miles away at MIT, where at the tender age of 24 he became a postdoc in the lab of Leonard Guarente, who had just started studying aging in yeast. Sinclairs colleagues remember him as someone who was aggressive, ambitious, and tireless: He was often the first to come into the lab and stayed as long as he could before dashing to catch the last train of the night. His colleague Shin-ichiro Imai, a professor of developmental biology at the Washington University School of Medicine who first met Sinclair in Guarentes lab, says Sinclair had a keen eye for capturing novel concepts and, based on that foundation, building new lines of research faster than anyone else.
At the time, aging research, once considered a fringe science, was still in its infancy, but Sinclair was determined to propel it to legitimacy. Three years into his time at MIT, he made a groundbreaking discovery that explained, for the first time, a mechanism of aging in yeast and opened up the possibility of one day manipulating the process in humans.
From there, Sinclairs career took off like a rocket. He soon left MIT to run his own lab at Harvard Medical School and became an assistant professor of genetics, continuing to build on discoveries made at Guarentes lab about sirtuins, a family of proteins that exists in all living beings. These proteins are usually dormant, but when activated through stressors (such as restricting calories), they can enhance health and extend life in yeast. Sinclair was determined to find a substance that could mimic the effects of restricting calories in yeast, something that could one day be turned into a medicine that cures aging.
True to form, he got to work, harder and faster than anyone else, Imai says. He screened some 20,000 substances until, one day, his collaborator called to say that hed gotten a hit: resveratrol, a molecule found in red wine that has long been suspected to play a role in human health. Sinclair couldnt believe what he was hearing and knew others wouldnt, either. So he set out to disprove the finding right on his dining room table, where he lined up a series of petri dishes filled with yeast that had been fed different substances. When he discovered that the dish with yeast that lived 50 percent longer had been fed resveratrol, he cried out to his wife, I think we have found something important here.
The discovery was the start of another phase in Sinclairs career, one in which wealthy investors played as much of a role as the scientific community. In 2004, with the help of serial biotech entrepreneur Christoph Westphal, he founded a company called Sirtris Pharmaceuticals to pursue clinical-stage drugs inspired by the resveratrol molecule. At the time, it was almost unheard of for a scientist in the aging field to start a company. David was a pioneer in merging academic and commercial research, Austad says. A lot of scientists would have liked to do what David did, but they didnt know how, or have the appropriate skills to raise the money and convince the investors that this science was promising a revolution in health. David did.
Meanwhile, in his lab, Sinclair pushed his studies up the evolutionary chain into mice, and in 2006 published the paper that would change his life: a study showing that overweight rodents fed resveratrol aged slower and stayed healthier than ones that did not consume the substance. It was an instant sensation, landing on the front page of the New York Times. Sinclair gave a few dozen interviews before sitting down, relaxed and charming, for the Charlie Rose show. A 60 Minutes special on resveratrol wasnt far behind, and soon he was telling Morley Safer we could expect an FDA-approved pill in five years time. Resveratrol, he once boasted to a reporter from the magazine Science, was as close to a miraculous molecule as you can find.
In no time, Sinclair went from being a scientist toiling away in a lab to someone whom strangers recognized on the street. He became a longevity guru to legions of people hoping to glean insight about how to forestall their own mortality. And, he became rich. Sirtris went public in 2007, and one year later, pharma giant GlaxoSmithKline snatched it up for an astounding $720 million. Resveratrol had made Sinclair famous and wealthy beyond what he had ever imagined, but it was also about to turn him into one of modern sciences most polarizing figures.
David Sinclair in his lab at Harvard Medical School. / Portrait by Ken Richardson
Sinclair was sitting at his desk at Harvard one day in 2010 when a colleague called to offer his heartfelt sympathies: Pfizer scientists had just released a paper essentially saying that Sinclairs work on sirtuins was bunk. When he finally got hold of the document himself, Sinclair couldnt believe his eyes. It wasnt clear to me at all that we were wrong, he told me. We had data that showed we were right.
And yet, it wasnt the first time Sinclairs science had been challenged. A couple of years after his initial groundbreaking yeast study on resveratrol, two of his former colleagues from Guarentes lab published a paper reporting on their inability to replicate it, suggesting his conclusions were wrong. A few years later, scientists from the pharma company Amgen also raised doubts, claiming Sinclairs findings were erroneous. The Pfizer paper, though, was different. Not only did one of the biggest pharma companies in the world claim he was wrong on resveratrol, it also stated his entire theory on sirtuins was completely off. In response, Sinclair publicly questioned whether the Pfizer scientists had made mistakes running their experimentwhich didnt exactly go over well. I was criticized for saying that Pfizer doesnt know how to make a molecule right, he explained.
As the scientific community continued to raise doubts and gossip behind his back, Sinclair sank to a dark place. I spent a week in bed, he told me. I couldnt get out. My lab shrunk to, like, four people. When I asked his assistant if she remembers what it was like when the Pfizer paper came out, she sighed, looked down, and shook her head from side to side: That was devastating.
Still, its hard to keep Sinclair down for long; after all, he lives by the very idea of never say die. When he finally got out of bed, he went back into the lab to prove his naysayers wrong. The day I visited his lab, he stood with his arms crossed and a look of satisfaction on his face as he showed me a framed copy of a 2013 scientific paper that he says settled the debate and proved he was right about resveratrol activating sirtuins. In it, he showed that when scientists genetically engineered cells to change a single amino acid on a sirtuin, resveratrol had no effect on the cells. In the control cells with intact sirtuins, however, resveratrol did have an effect.
Not everyone, though, was convinced. There are lots of people in the field who harbor suspicions [about Sinclairs science], one researcher told me. It is hard to explain how the same lab on multiple occasions over a decade or so can publish multiple pieces of data that other labs cant reproduce. Whats more, GlaxoSmithKline halted a Sirtris trial in humans because of potential negative side effects and then shut the company down altogether just five years after buying it. Today, resveratrol is known as the miracle drug that wasnt.
To Sinclairs credit, none of his scientific papers have ever been retractedand none of the people who spoke to me about their suspicions of Sinclair wanted their names used. One of them admitted that it might not be his data that critics object to, but rather the way Sinclair talks about his findings. While his colleagues in the aging field overwhelmingly stick to a safe script, describing their research as a quest to extend years of health, Sinclair talks freely and excitedly about extending mortality to 150 years by the end of the centuryto say nothing of death eventually becoming a rarityboth of which critics say there is zero science to support. From his exalted platform as a scientist featured on TV and in the New York Times, Sinclair is promising the world that one day soon well be able to get a shot that reverses aging, and when it wears off and the gray hairs sprout again, well simply get a booster. Does that sound like science fiction? Something that is very far out in the future? Sinclair asks readers in his book. Let me be clear: its not.
Even the title of his bookthe part that says we dont have to ageelicited an exasperated groan from the Harvard Medical School professor. What is wrong with the guy that he is compelled to do this? he asks. Seen in the best possible way, he is totally convinced that he is the savior of mankind developing the fountain of youth. But you dont have to hype to do that. Just let the facts play out. Even his friends call him out for how he talks about his science. David is a good friend, Austad says, but I do think hes been guilty of making excessive claims.
Despite the resveratrol fiasco, Sinclair hasnt shied away from making other grandiose promises. One of his more recent molecules of interest is called NMN. It is found in every living cell and boosts levels of something called NAD+, which regulates the mitochondria, or powerhouses, in all of our cells. NAD+ declines with ageunless, that is, scientists like Sinclair can find a way to increase it. Last year, he told Time magazine that NAD+ is the closest weve gotten to a fountain of youth.
If Sinclairs public comments push past the limits of what most scientists would say, it is also true that his accomplishments in the lab continue to push the limits of science itself. When I met with Sinclair, he told me he is gearing up to publish a paper about how his lab reversed aging in rodents. He described a series of experiments using gene therapy in which he and a group of scientists were able to restore vision in mice with glaucoma as well as in other mice who had their optic nerves (which cannot grow back after the newborn period) crushed. Sinclairs team had made a handful of old mice young again.
In light of the cutting-edge experiments and advances he is making in his lab, I was surprised that Sinclair also continues to study resveratrol. It seems so yesterday. When I asked about it, he assured me with a self-confident nod that he is still bullish on resveratrol. The 2013 paper, the one on his wall he believes vindicated him, didnt get the word out far and wide enough, he says. Thats why his lab did another experimentthis time deactivating a spot on the sirtuin protein in miceto show that resveratrol does, in fact, work. He tells me hes really looking forward to that study coming out to restore faith in resveratrol. And, it seems, perhaps to restore faith in Sinclair, too. When that one comes in, he says of the forthcoming paper, Im going to dropthe mike.
If Sinclairs public comments push past the limits of what most scientists would say, it is also true that his accomplishments in the lab continue to push the limits of science itself.
As Sinclair and I neared our destination in Worcester, I had my head down, furiously scribbling in my notebook, when I felt the car swerve abruptly to the right. I looked up to see Sinclair, visibly frustrated, struggling with the Teslas steering wheel. My car appears to have been set to Mad Max mode, he said in his pitch-perfect Australian accent. I promise not to get us killed. Then he added wryly, That would be ironic.
It would, indeed. After all, Sinclair is planning on being around for a lot longer than most people think they will. He convinced his dentist to fix some wear on his teeth, a procedure that she told him shed normally reserve only for teenagers. He dedicated his book to his great-great-grandchildren, whom he is very much looking forward to meeting.
To make it until then, he practices calorie restriction, eats a mostly vegetarian diet, and tries to avoid sugar and carbs. On weekends, he exercises at the gym and then sits in a hot sauna before plunging himself into an ice-cold pool, because temperature extremes also kick our cells survival instincts into action, he says. Sinclair tracks his biomarkers regularly and takes vitamin D, vitamin K2, and aspirin. And he takes three other substances each morning: resveratrol, NMN, and metformin, a diabetes drug currently being studied for its potential anti-aging effects. The problem, critics say, is that unlike cancer drugs, for instance, nearly anyone can buy something close to the NMN and resveratrol capsules Sinclair is downing at places like the local GNC, where theyre sold as supplements alongside multivitamins and protein powder.
Sinclair diligently points out that he is not a medical doctor; that he is not recommending anyone do what he does; and that there is no definitive evidence that any of it helps humans. Still, critics say that when a scientist such as Sinclair tells people what he is taking, it is nothing short of a celebrity endorsement, those caveats notwithstanding. In his defense, he told me he gets dozens of emails and messages every day from people asking him what theyor their petsshould be taking, and that he never makes recommendations. But its also hard to imagine people would write to ask him at all if he werent talking so publiclyand so oftenabout his daily regimen. I like David a lot. Were very good friends. However, I dont think that what hes doing is right, says Felipe Sierra, the director of the aging biology division at the National Institute of Aging. I dont think that people should try it on themselves. And if they do, they shouldnt publicize it. Researchers do have a responsibility toward the public, and we should be careful about what we tell the public.
Sinclair knows he ruffles feathers: At one point during our day together, I asked him where his family members get their pills from. He raised his eyebrows at me and then said in a Big-Brother-might-be-listening kind of whisper that we were in territory that could get me called into the office, and it wouldnt be the first time. Still, he says he is prepared to deal with the consequences of being honest.
Whats more, Sinclair says he has nothing to do with the supplement industry, a claim that is mostly true. All of the companies he has started are working on creating FDA-approved drugs, not supplements. True, years ago he did work as a paid adviser to a resveratrol supplement company, Shaklee, though Sinclair says he cut off that relationship when the company started using his name for marketing.
Even if Sinclair isnt directly profiting when people buy supplements after hearing him speak, he may still be benefiting financially from talking about what he takes. Think about what the optics would be if someone says, Ive got this great potential therapeutic intervention, and then says theyre not taking it. Suddenly you are putting up red flags about your own science, Olshansky, the Illinois professor, says. So I can see why somebody who has a financial interest in a molecule would take it and brag about it. If it helps them get more money to do research, that may be one of the reasons they do it. Sierra, for his part, admits that as much as he dislikes when Sinclair shares what he is taking, it is probably good for commercial purposes.
Whether or not his personal habits have helped Sinclairs bottom line, theres no doubt hes raised a ton of funding and used it to start a slew of companies. Seven of them fall under the umbrella of Life Biosciences, a Boston holding company he cofounded with Australian investor Tristan Edwards with the goal of building clinical-stage biotech companies by harnessing the best science in the aging field. Edwards had been interested in the longevity space and searched for a scientist to work with. He had a call with Sinclair and was so convinced by what he heard that before he got off the phone, he had already booked a flight to Boston. The firm raised $25 million while in stealth mode in 2017 and has since raised $500 million more.
Another company, MetroBiotech (which falls under the holding company EdenRoc Sciences), is pursuing drugs inspired by the NAD+ booster NMN. Thats the one we were on our way to visit when Sinclairs Tesla tried to kill us. Upon our arrival, two men looking slightly disheveled and both wearing Hawaiian shirts greeted us; these were the organic chemists tasked with developing molecules that may one day become an FDA-approved drug. As they took me back to their lab, I noticed the paunch on one of them, the wrinkles on the other, and the fact that what little hair either of them had left on their heads was somewhere between gray and white. I lowered my voice and asked, So are you guys, you know, taking the stuff?
Of course not. We are scientists! one of them exclaimed, looking at me like I was the mad scientist in the room.
It doesnt take a PhD to know that the fact that two guys who arent taking NMN look old proves absolutely nothing. But it did make me feel a little more hopeful to learn that they were not. And the funny thing is that later in the day, when I asked Sinclair why he takes unapproved drugs knowing that there could be risks (and how much it pisses people off), he said the very same thing: I take them because I am a scientist.
Then, in total deadpan, he gave me another reason.
And because I would like to outlive my enemies.
David Sinclair with his wife, Sandra Luikenhuis, at the Time 100 party after the publication named him one of the worlds most influential people in 2014. / Getty Images
Sinclair and I were supposed to be at the gym at 5 p.m. to meet up with his 12-year-old son, Ben, and his about-to-be-80-year-old father. Because we were running late, he asked his wife to send his gym clothes with his dad. When we arrived, Sinclair came out of the locker room in his dress shoes. His wife, despite taking NMN herself, had forgotten to send his sneakers. Luckily, the trainer had an extra pair, and the Sinclair family got down to business.
First up were dead lifts. Ben had a go and did pretty well for a kid his age. Then Sinclair went. He started to wince midway into the second set but made it through. Finally, his father had his turn, dead-lifting 95 and then 115 pounds like it was nothing. The trainer told me most of his 80-year-old clients are working on maintaining their balance and lifting themselves out of chairs. Sinclairs dad is killing it in the gym. Well, I suppose the only thing this proves is how useless I am, Sinclair told me, frowning.
Of course, he is hoping it means something else. His father has been taking NMN for two years, and since starting, Sinclair said, it has changed his life, his attitude, and his energy levels. It has returned to him his joie de vivre.
When I asked Sinclairs dad directly how the pills are going for him, I realized that Sinclair definitely did not get his salesmanship skills from his father. Cant tell, he told me flatly, with a shrug. But all my friends are dying or going downhill and Im not.
Not only are Sinclairs dad and wife taking NMN, but so are his two dogs. His younger brother grew gray hairs and developed wrinkles before he accused Sinclair of using him as a negative control in his little family experiment. Sinclair admits the thought did cross his mind, but blood is thicker than science, and now his brother is on the regimen, too. Even several of his graduate students are taking some of the pills. When the postmenopausal mother of one of those grad students also began taking it, she started menstruating again. (Perhaps unsurprisingly, Sinclair has a fertility company, too.)
There was one person who never got the chance to take NMN, however, and it seems to haunt Sinclair. His mother was diagnosed with lung cancer at age 50 and had a lung removed. She managed to live another 20 years with one lung, which Sinclair says he would like to think had something to do with the fact that she took resveratrol. At the end of her life, when she took a turn for the worse, Sinclair packed some NMN in his suitcase and boarded a flight to Australia. When he got there, she started doing so much better that the doctors took her off her respirator, and she never took the NMN. She died unexpectedly 12 hours later. I thought the NMN would save her, he admits. Wouldnt anybody do whatever they can to try to save their mother?
As their workout wore on, Sinclairs son Ben had something he wanted to tell me. He wanted me to know that he would like to continue his fathers work if he ever dies. I was distracted from the tenderness of this statement by the presence of a single preposition.
If? I asked.
He may never die, he said.
I shrugged and smiled, but inside I was thinking that if he isnt joking, someone is in for a real shocker. Earlier in the day, Sinclair told me he was such a straight-talker that he had ruined the illusion of Santa Claus for his childrenand yet here his son could be thinking his father might never die. Such is life in the Sinclair household.
Still, not everyone in the family wants to see people live forever. Sinclairs oldest daughter doesnt agree with his work and has zero qualms about letting her dad know it. She has asked him why, when previous generations have screwed up this planet so royally, he thinks its a good idea to have the people who did the damage hang around any longer. She is not the only one. Emory University bioethicist Paul Root Wolpe, for instance, has called the longevity field a narcissistic quest and points out that generational shifts are necessary for innovation, progress, and social change.
As if in response, Sinclairs book has an end section in which he delves into many ways to fix the world he wants to create. There is, he argues, a solution to everything in a reality where people live to 150overpopulation, inequality, natural-resource limitationsif you are as hopeful as he is. Just as I was finishing up this piece, in fact, scientists published a study linking optimism to longevitymeaning Sinclair could stand to add even more years to his life. Indeed, if I squint hard enough, I can practically see him growing younger before my very eyes.