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Category Archives: David Sinclair
If you, like much of the world, find yourself twiddling your thumbs in self-isolation amid the ongoing coronavirus pandemic this book list is for you.
In the words of the great Susan Sontag, The day has pockets you can always find time to read.
And because we have no idea how long the COVID-19 crisis will continue, many of us are faced with a lot of time to kill.
From entertainment and escapism to a dystopian novel thats eerily similar to the current climate, these books will enrich your self-isolation.
Stephen King It starts with a cough, then your neck swells, your nose starts to bleed and your eyes bulge out of their sockets. Death comes just hours later. Kings 1978 novel follows the breakdown of society after a strain of the flu that has been modified to be used for biological warfare is accidentally released, killing 99% of the population. Its then up to a tiny handful of survivors to rebuild society. Comparisons between COVID-19 and Kings fictitious flu are already being made, with the author tweeting in response, Its not anywhere near as serious. Its eminently survivable. Keep calm and take all reasonable precautions.
Sheryl Sandberg This game-changing book became an international bestseller for good reason. Facebook COO Sheryl Sandberg has had decades of experience climbing the corporate ladder at successful technology startups all while balancing family life. She covers everything from how to find a mentor at work to voicing your opinion, becoming a leader in your organisation, forging an equal partnership in your home life and what true equality should look like in the workplace. Balancing light humour with solemn advice, Lean In is a call to action for personal growth that can empower women around the world to achieve their full potential.
Mark OConnell Insightful, life-affirming and slightly terrifying, this book follows OConnell as he travels the globe in search of answers regarding the impending climate apocalypse. He tours survival bunkers in South Dakota, visits the billionaires bunkers in New Zealand and interviews everyone from doomsday preppers to conspiracy theorists. With insight, humanity and wit, OConnell leaves you wondering, What if the end of the world isnt the end of the world?
David A Sinclair What if everything weve been taught to believe about ageing is wrong? What if we could choose our lifespan? The paradigm-shifting book from David Sinclair, acclaimed Harvard Medical School scientist and one of Times most influential people, reveals a bold new theory for why we age. He posits, Ageing is a disease, and that disease is treatable. At a time when the health of the world is threatened, this book will change the way you think about ageing and what we can do about it.
Jessica Anthony What does taxidermy have in common with the current American political climate? A lot, according to Jessica Anthony. Inventive, original and darkly funny, this novel examines how and why a young Republican congressman discovers a mysterious stuffed aardvark placed on his doorstep. It then leaps between contemporary Washington DC and Victorian England, where readers meet the taxidermist who stuffed the creature and the naturalist who hunted it, offering a uniquely unsettling view of how male power has evolved over time.
James McBride The National Book Award winners dazzling, spiritually rich novel opens in 1969 when a boozy Brooklyn deacon guns down a drug dealer. The incident brings together an array of social groups from the African-American and Latinx residents who witnessed the crime to the members of the deacons church as they seek to understand why the violence occurred and how it relates to the multicultural history of their community.
Quan Barry Almost 300 years after the witch trials, a Massachusetts high school field hockey team is determined to make it to the state finals. After a losing streak, their luck starts to turn around after team members begin signing their names in what might be a magical notebook. The novel evolves into a nostalgic coming-of-age story that explores the teams mission to win and their experimentation with witchcraft.
Read next: 10 podcasts to binge right now
Read more from the original source:
7 books to read while in coronavirus quarantine or isolation - The CEO Magazine
Sinclair was scheduled to discuss his ideas with Norman Swan, host of Radio Nationals Health Report, at Ageing is a Disease at Sydney Town Hall on April 4 as part of the Festival of Dangerous Ideas, which was cancelled last week.
David Sinclair says ageing fulfils every criteria for what medical textbooks define as a disease.Credit:Nic Walker
Sinclair says the coronavirus pandemic, which is causing a higher fatality rate among the elderly, gives urgency to his research into the ageing process. "Our research is aimed at delaying or reversing age-related diseases and providing the elderly with resilience," he says. "Other labs have shown in human clinical trials that immune responses in the elderly can be boosted by molecules that target ageing, such as low dose rapamycin."
But Sinclairs argument that ageing is a disease may cause some unease. He says ageing causes frailty, sickness and eventually death, fulfilling every criteria for what medical textbooks define as a disease. The only difference is that ageing happens to everyone, whereas cancer and heart disease do not. Were very good at preventing heart disease but we havent been successful at delaying ageing of the brain, he says. So weve ended up with the worst nightmare - were increasing lifespan but not healthspan as much.
"Its also not recognised that age is what causes those diseases in the first place," he adds.
Describing ageing as a disease also sounds to some ears like it is stigmatising older people. I find that people over 50 tend to get upset when you call ageing a disease, he says. But people under 50, particularly people in their 20s and 30s, they totally embrace this idea. They don't want to get sick. They think technology can solve everything.
Sinclairs book Lifespan, subtitled Why We Age, and Why We Don't Have To, outlines his 25 years of research into ageing, which he likens to corrupted software.
Getting older amounts to a loss of what he calls epigenetic information. Essentially its the information that tells the cells how to read the genes in the right way and stay young, he says. In the same way that a genome is the computer, the epigenome is the software. And so I'm proposing that ageing is corrupted software.
Sinclair says his research has also revealed there is a back-up copy of our software. If its corrupted, weve figured out a way to reboot the cell and be young again.
In Lifespan, he describes experiments in which old mice have been given gene therapy that restores their eyesight to that of young mice. The idea is we still have all the information to be young again in our bodies if we can just flip the switch, he says.
Sinclairs effort to reboot cells is undergoing pre-clinical trials to test the safety and efficacy of the procedure. Within the next three years, he aims to treat patients who have lost their vision as a result of glaucoma - a disease that can be controlled but cannot be cured.
Do I know if its going to work in people? he says. Of course not. Nobody knows until you do the clinical trials.
Sinclairs research into ageing is slowly gaining acceptance among scientists and medical professionals. British scientists Robert Faragher and Stuart Calimport said last year on academic website The Conversation that the World Health Organisations International Classification of Disease should be amended to classify ageing as a disease.
However, Sinclair says it is hard to change regulations and the habits of doctors who have been taught that ageing is inevitable and not something we can treat.
It takes radical thinking to overcome what youve taken for granted your whole life, he says.
Sinclair traces his interest in ageing to childhood and a conversation with his grandmother Vera. I remember very clearly that my grandmother told me everything is going to die, he says. The cat was going to die, she was going to die and my parents and I would.
Sinclair describes his grandmother as a huge rebel who taught him to question dogma and authority. He recalls with pride how she was ejected from Bondi Beach in 1957 for wearing a bikini one year after she fled Hungary following the Soviet invasion. She taught me that humans can do evil and can do amazing good, he says. And she said: David that's what you should do with your life is leave the world better than you found it.
Sinclair says his aim is not to cheat death, but to allow older people to stay healthier for longer. There are plenty of people who look at what its like to be 100 and say Heaven forbid, I don't want to get old, he says. But thats missing the point, which is you could be 80 or 90 and still play tennis and hang out with your grandkids and be productive like my father is at 80.
Sinclair says preventing illness is the key to improving quality of life and reducing the burden on family and society. Its what we see in our animal studies, he says. They live longer because theyre healthy. Thats the only way I know to keep something living longer is to prevent them getting sick.
However, Sinclair cautions that his research will not deliver the magic bullet that allows people to eat, drink and be merry without consequence. If you live a healthy lifestyle and eat all the right foods are you going to live beyond 120? Probably not, he says. On the other hand, the average lifespan for humans used to be about 40 years. And weve used technology to improve our health - thats what we do as human beings."
Andrew Taylor is a Senior Reporter for The Sydney Morning Herald.
Read more from the original source:
Flipping the switch on the ageing process - The Age
From left, Pilot staff photographer Ted Fitzgerald, reporter Laura Douglass, editor John Nagy, reporter Jaymie Baxley, and The Sway's Mackenzie Francisco, Melissa Kohlman, and Abbi Overfelt. Photo: David Woronoff/The Pilot
The Pilot took home the prestigious first place award in General Excellence in its division at the annual North Carolina Press Association News, Editorial and Photojournalism contest held Thursday.
The 2019 awards were presented Thursday as part of the NCPAs Winter Institute. More than 100 newspapers from across the state were represented and 4,400 entries were submitted..
In competition among non-daily community newspapers with circulation over 10,000, The Pilots staff members accounted for 16 news and editorial and 19 advertising awards presented at the Marriott Crabtree Valley in Raleigh.
The Pilot has previously earned the top award for General Excellence in 2017, and 2010. The Pilot placed third in that category in 2015 and last year.
Our core purpose has always been to serve our community. We believe that publishing a great newspaper is the best service we can render, said Pilot publisher David Wornoff. While were proud of this award as it recognizes the outstanding work of our dedicated staff, its the pride that our readers feel for the newspaper that brings infinitely more satisfaction.
In addition to print content, The Pilot swept the email newsletter category, taking first place for the twice-weekly Pilots Briefing, and second and third place honors for The Sway.
The top prize for best niche publication went to Pinestraw magazine, produced by The Pilot; and the special section Best of The Pines earned first place in the category, with A Guide to the Sandhills taking second place.
Publisher David Woronoff and editor John Nagy earned first place for editorial page, and Nagy took home third place in the individual category for editorials.
An emphasis on the transparency, and consequently the quality, of local government provides a service to readers of The Pilot, the judges said.
Among the other individual news awards to members of The Pilot staff, writer Deborah Salomon took first place in beat feature reporting and third place in feature writing.
Reporter Jayme Baxley took second place for sports enterprise writing.
Managing editor David Sinclair took third place in sports columns and third place in sports feature photography.
Staff photographer Ted Fitzgerald slid into second place in sports feature photography and third place in photo page or essay.
Fitzgerald, Sinclair and Brandi Swarms also earned third place in the feature photography category for their front page coverage of area high school graduation ceremonies last June.
The recognition of our peers is gratifying, but the feedback that means more to us is what we receive from people in the grocery store aisles and at church and around town, said editor John Nagy. The Pilots strength has always been and remains the connections its people have with their community.
In a separate ceremony Thursday afternoon, The Pilots advertising staff collected 19 awards for their work, including top honors for best overall performance for the third consecutive year.
Patty Thompson and Scott Yancey racked up an impressive number of first place awards in advertising categories, including healthcare and medical, best home furnishings and appliance ad, for a retail ad and, separately, a service ad in a niche publication.
From left, ad rep Samantha Cunningham, advertising director Ginny Trigg, and graphic design manager Mechelle Butler.
Yancey also earned first place with Dacia Burch for best apparel, jewelry and accessories ad.
The Pilots ad staff earned first place in the community services signature page for their Valentines Gift Guide, first place and second place in the niche publication category, and first place and third place for special section.
Wow. Just wow, the judges said. Every page is gorgeous photo, content, layout work together with flare, elegance and personality.
Thompson and Yancey also individually took second place for apparel, jewelry and accessories ad and healthcare medical ad.
Perry Loflin and Yancey took second place for retail ad in a niche publication.
A third place award was presented to Burch and Yancey, and Terry Hartsell and Mechelle Butler for home furnishings and appliance ad. Additional third place prizes were awarded to Thompson and Yancey for retail ad, and Butler and Samantha Cunningham for use of color in advertising.
Were so proud of the fantastic work that our advertising team produces all year long, said Ginny Trigg, The Pilots advertising director. It's especially rewarding to be recognized by our industry peers for the ads that were creating. We share the awards with our advertising partners for trusting us with their marketing.
The Pilots winning advertisement partners included CoolSweats, Monkees of the Pines, Burney Hardware, Wedgies, Bell Tree, Sweet Dreams Mattresses and More, Elmore Furniture, Pinehurst Medical Clinic, Karma Beauty Bar, Sothebys, The Ice Cream Parlor.
Originally posted here:
Pilot Wins Top Honors at Awards Ceremony | Business - Southern Pines Pilot
Southland A&P Show officials Vic and David Sinclair help set up for the big event on Saturday.
Vic Sinclair has gone from anexhibitor to avolunteer to help ensure the future of theSouthland A&P Show.
After Sinclairand her children exhibited for the first timein2018, she and husband David decided to become more involved with the show.
"Events like the show can only be run by committed volunteers ... you get a lot of satisfaction from volunteer work," Vic said.
"We want the show to have a future so our kids can participatein it.
"It's something our kids can connect to and it links to the agricultural roots of Southland."
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The Sinclairs are marshalls for the entertainment and tradesections, while David is also vice-president for the 152nd show in Invercargillon Saturday.
Southland A&P Show committeemen - Noel Hamilton (50 years' service) left, Graham Calder (35) and Owen Anderson (42) - have been officials of the organisation for a combined total of 127 years.
Entertainment and business/trade displayswere sections of the show identified as expansion areasin a 2018 strategic report. The report was commissioned by the show executive.
A new marketing approachlast year saw an increase in business/trade displays, craft stalls, live musicandperformances. Numbers are high again this year and forthe first time,a lifestyle block section will be operating.
Show president Paula Bell said the report provided important information to future proofingthe annual event. It helped attract about 5000 people last year and she expecteda similar number, if not more,with fine weather on Saturday.
Meanwhile, long serving committeemen Noel Hamilton (50 years), Graham Calder (35) andOwen Anderson (42) have contributed to the showfor a total of 127 years.
"The show gives town families a touch of the country ... it lets them see what we do," Hamilton said.
Hamilton and Calder are sheep marshalls and the latter is sometimes surprised by children's comments.
"You talk to them [and somesay] they've never been up close to a sheep before," Calder said.
A caterpillar made out of hay bales, positioned at the entrance to the Southland A&P Show's venue in Invercargill, is part of the marketing for the event on Saturday. Show president Paula Bell is with Kurt Wilson who painted the caterpillar.
He and another breeder jointly owned the ram that was last year'sSupreme Champion Sheep. A ram, entered solely by Calder, won the title in 2016.
"I'd been trying for 40 years to win it and I got it.
"It makes it worthwhile when you get the top prize."
See the original post:
Southland couple join volunteers to help future proof Southland A&P Show - Stuff.co.nz
The Marmot Review revisited ten years on
Feb 27th 2020
TEN YEARS ago the Marmot Review, a study commissioned by the government, asked a big, complicated question: why do some people in England live longer, healthier lives than others, and what can be done to reduce the gap? The answer it found was simple. Some people lived longer because they were better-off. To change this, it concluded, the government would have to reduce social inequality.
A new report by its author, Sir Michael Marmot of University College London, reviews the past decades changes. The numbers speak for themselves. In the three decades leading up to the first report, life expectancy at birth for men increased by a year every four years. Between 2011 and 2018 that rate slowed to a year every 15 years. For women the decline was even starker, from a year every five-and-a-half years to one every 28 years. And for the very poorest women, things have gone backwards. Life expectancy for those in the most deprived areas has declined by 0.3 years from 2010-12 to 2016-18. All women born later in the past decade are expected to have fewer healthy years than those born at the start of it.
Moreover, both men and women under the age of 50, particularly between 45 and 49, have seen mortality rates tick up (see chart). Sir Michael suggests that this could be related to suicide, alcohol use and rising drug toxicity, making it the British version of rising mortality rates among poor Americans, termed deaths of despair by Anne Case and Sir Angus Deaton, two economists who study the phenomenon.
What happened? The report stops short of putting the blame squarely on austerity, though it notes government spending has declined sharply in the past decade. One reason women may have suffered more than men is that spending cuts hit them harder. Research by the House of Commons library found that the majority of reductions have been borne by women, because the benefits they were likelier to receive saw deep cuts. Regional differences matter too. Poorer areas in the north are even more likely to have worse health than those in the south-east. I invite you to speculate that it is highly likely that some of these [cuts] will have had an adverse effect on health, says Sir Michael.
Yet the link between austerity and poor health is hard to pin down. David Sinclair of the International Longevity Centre, a think-tank, points out that several European countries underwent a period of austerity in the 2010s without drastically worsening health outcomes. And increases in life expectancy have slowed across the rich world, notes David Buck of The Kings Fund, another think-tank, though the slowdown in Britain has been sharper than most. Both Davids agree with Sir Michael that to improve public health governments must spend not just on health services but also on education, child support and community services. The health secretary, Matt Hancock, also welcomed the report. He said were committed to levelling up, and levelling up, and levelling up. He said levelling up four times I think, says Sir Michael, referring to the governments plan to boost poor parts of the country. And in case I hadnt got it: levelling up.
This article appeared in the Britain section of the print edition under the headline "Groundhog day"
Alliant National Announces Addition of Executive Vice President and National Agency Manager
Alliant National Title Insurance Company, a unique title insurance underwriter that partners with independent agents to improve their competitive position in the marketplace, announced that Rodney Anderson has been promoted to executive vice president and national agency manager, effective immediately.
Anderson will expand his current responsibilities for developing, marketing and managing Alliant Nationals Southwest Region Agency operations to include national market expansion and oversight of the companys 32 licensed state agency operations.
Anderson will be a member of the senior executive leadership team working to aggressively expand Alliant Nationals footprint.
I am honored that our CEO and ownership group, Presidio Partners, has placed their trust in me with such a key role within Alliant National, says Anderson. Throughout my career I have worked to support the independent agent, and I look very forward to working with the agency team assembled at Alliant National to help independent agents across the country.
Anderson is a seasoned real estate and title insurance industry expert with over thirty years experience in agency operations as the current Southwest regional manager for Alliant National, former co-owner of an independent title agency, and agency operations manager for a national independent agency. In addition, Mr. Anderson served three full terms as a State Representative in the Texas Legislature.
It is not often one gets the opportunity to work side-by-side with an industry professional of Rodneys caliber, says David Sinclair, Alliant National president and CEO. His unique experience combined with his passion for independent agents makes him the perfect person to lead our agency team, particularly at this juncture of accelerated company growth.
Alliant National distinguishes itself from competitors by combining strong underwriting capability with independent agents in-depth knowledge of local markets. The result is a nationwide network with deep roots in local communities, and a wealth of expertise that is flexible, nuanced and continuously growing.
Gensler Promotes 9 in Denver
Gensler, a global architecture, design, and planning firm, announced the promotion of nine in its Denver office.
Juan Padilla,Rebekah Wagoner,AIA, LEED-AP, and Austin Zike, NCIDQ, IIDA, RIDwere promoted to associate.Juan Padilla is an architectural designer with experience across workplace to lifestyle project types.Rebekah Wagoner is an architect with 10+ years of experience with a passion for sustainable solutions for the built environment. Austin Zike is a senior project manager with 20+ years of experience successfully delivering large, complex projects across many sectors of workplace design.
Joy Hughes, AIA, Ronnie Leone, IIDA, ErinVinezeano, AIA, and Michael Yeager, AIA were promoted to senior associate. Joy Hughes has been an architect with Gensler for 20 years and is a regional leader forthecritical facilities practice area.Ronnie Leone is an interior designer with 10+ years of experience designing award-winning creative workplaces for technology and financial services firms.She is also takingon a new role as Co-Studio Director. ErinVinezeano is an architect and interior designer with 10+ years of experience in a wide range of project types, from professional services to technology workplaces, including multiple nationally publicized workspaces.Michael Yeager is anarchitect with 20+ years of experience in a range of project types, recently leading three major development projects in Denver.
Christy Headlee, IIDA, LEED AP and Alex Garrison, AIA were promoted to design director. Gensler design directorsare thought leaders and stewardsfor design excellence; they are responsible for overall design quality of their projects and advancing the Gensler design culture. Christy Headlee is an interior designer with 10+ years of experience. She leads design efforts with intention and bold creativity. She is collaborative, passionate about inspiring and empowering others and is an inclusive leader who mentors and inspires others to explore their own creativity. Alex Garrison is an architect with 10+ years of experience. He is an award-winning designer who brings a strong conceptual approach to every design opportunity. A firm believer in always being curious, he leads project teams in the tireless pursuit of innovative design solutions.
Dunton Commercial Announces Two New Hires
Dunton Commercial, a Denver-based commercial property management and investment company has hired Brett Welker as the new director of property management and Caleb Krumsieg as the new director of Leasing.
Welker brings tremendous experience and leadership to our property management team, as well as asset management, acquisitions analysis and due diligence to our investment side of the business. He has achieved the designations of RPA (Real Property Administrator, BOMA) and CPM (Certified Property Manager, IREM).Prior to Dunton, Welker spent 21 years with Lowe, a commercial real estate investment company, most recently as vice president.
Krumsiegs focus at Dunton is to maintain high occupancy levels within the portfolio by leveraging Duntons technology and implementing a highly pro-active leasing strategy. He brings significant office and retail leasing experience to Dunton, most recently as a broker with Waveland Property Group in Wheaton, IL. Krumsieg has a B.A. in Business and Economics from Wheaton College.
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Movers and Shakers Week Ending 2.28.20 - milehighcre.com