Category Archives: David Sinclair

Kris Jones came out on top with an incredibly quick time of 63 minutes and 46 seconds

Around 11,000 runners descended upon a gloriously sunny Trafford this morning (Sunday October 9) for the Manchester Half Marathon. Competitors and spectators alike were treated to perfect weather and gorgeous blue skies for the 13.1 mile run through the streets of Sale, Stretford, and for the first time ever, Manchester city centre.

Kris Jones, of Swansea Harriers, came out on top with an incredibly quick time of 63 minutes and 46 seconds. James Tilley (Nantwich) and Chorlton's own Tom Charles came second and third respectively.

James' dad Neil Tilley was bursting with pride as he spoke with the Manchester Evening News after watching his son get silver. He said: "I'm so proud. It's his first year of proper marathon running and that's the fastest I've ever seen him. He came 25th in the full marathon earlier this year but this is his best result in a major race over here."

Stockport Harriers runner Mollie Williams won in the women's category for a second year in a row, with an impressive time of 73 minutes and 29 seconds. David Sinclair took the wheelchair half marathon crown, finishing in 84 minutes and nine seconds.

Competitors' friends and family created a great atmosphere throughout, with many bringing signs and cheering their loved ones on, while Manchester music from the likes of Oasis, Courteeners and M People blasted out of the PA system speakers at the start and finish lines.

Plenty of runners donned fancy dress and ran for charities, with the highlight probably being The Justice League's Wonder Woman, The Flash and Batman, running alongside Avenger Captain America. Despite athletes trying to better their own personal records, a couple of competitors stopped to help a runner named Andy Matthews over the line, when it became clear that he was struggling.

A gallery of photos from the race can be found below:

Link:
Manchester Half Marathon 2022 in pictures as thousands race along sunny streets of Greater Manchester - Manchester Evening News

Home sharing is growing in popularity among older adults, as new research reveals, one in three people over 55 would consider having a housemate in later life to save money and avoid living alone.

Proving best friends are forever, almost a third (31 percent) of the 2,000 over 55-year-olds surveyed said they would be open to moving in with a friend in retirement, with more than one in six (18 percent) admitting that theyd rather live with friends than family. An adventurous four percent said theyd consider renting with a complete stranger.

According to property management service provider, FirstPort, who commissioned the study, the retirement roomie trend will only continue to grow as people look to save money.

The company has already seen a 27 percent increase in enquiries for independent-living retirement developments in the last year, with many requesting to move to the same development as their friends some even as next-door neighbours.

According to the research, 12 percent of the Baby Boomers questioned said the pandemic had changed their attitude towards communal living. However, for 63 percent of surveyors, financial fears remained their biggest concern.

Other reasons cited for co-living were company (40 percent), safety (25 percent) and sharing household chores and admin (15 percent).

Suggesting its not all doom and gloom, one in five (20 percent) said theyd live with others to have fun and 17 percent would do so to enjoy shared hobbies and interests together.

READ MORE:Best trick to successfully clean grout - costs pennies

When asked what they fear most about later life living, a solid 68 percent of people said losing their independence, closely followed by not having enough money at 48 percent. One in six (15 percent) were concerned about losing touch with family and friends, whereas 38 percent of people said being alone was their biggest fear.

A review of social media and retirement forums online found that friends and making friends were the most frequently used words in conversations about later life.

David Sinclair, Chief Executive of the International Longevity Centre UK (ILC) says: "As we get older, we spend an increasing amount of time at home alone and watching television. In old age our network of friends and family is often smaller than it was. One in five of us doesnt have children and we are more likely than in the past to be divorced or separated.

Wed like to see more diverse options for housing for older people, and this includes living with friends, which shouldnt just be for younger people. House-sharing is a great way to build and strengthen relationships and enjoy the company of others, rather than just the characters on our TV screens.

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Gareth Cayford, Director Retirement at FirstPort says: The events of the last few years have had a seismic impact on peoples attitudes towards later life, leading many to completely rethink what they want in retirement, and who they want to spend it with.

We are seeing a growing number of enquiries for friends and families looking to live near each other or in the same development buildings, and we expect this to continue to rise in the future especially with increasing living costs.

"Its not just a prudent choice but one that demonstrates that independent retirement development living - with communal lounges and spaces to socialise with friends - is more important than ever.

Ceinwen Kerslake (85) and Gillian Morgan (77), have been friends for over 40 years and live next door to each other in communal development, Homegower House, Swansea.

Gillian says: After both losing our husbands, we each experienced the loneliness of being widows living in larger houses and wanted to downsize. I would come and visit Cei who moved into the development first, and eventually decided to buy a flat of my own right next door!

Living next door to each other has brought us closer together as friends, we now spend five days a week together, doing activities like eating out with friends and joining in the development activities.

Cei added: Living so close to each other gives us the peace of mind that we can rely on each other when needed, whether thats a medical emergency or just borrowing milk for a cup of tea.

We actually tend to share food and save money on our weekly shop! We never expected to live so close to each other in later life but the company we offer has brought us so much joy, we would encourage anyone in a similar situation to us to do the same.

See the original post:
Over 55s turn to house shares to save money and avoid loneliness - Express

In the second podcast based on his book LifeSpan, Dr. Sinclair talks about the science behind how fasting and eating certain foods promote longevity.

Highlights:

In the second podcast episode of Lifespan with Dr. David Sinclair, he and co-host Matthew LaPlante discuss how we can live longer by changing the way we eat. They guide listeners towards a path to longer living by examining how we can change our eating habits to live longer, all while explaining the relevant science.

If three words could sum up how to live longer by changing our eating habits, Dr. Sinclair would say, eat less often. This does not necessarily mean consuming fewer calories but packing in the calories within a shorter period. In fact, we need calories to avoid malnourishment and starvation.

Why eat less often? For Sinclair, it started with a study showing that the lifespan of dogs could be increased by reducing their caloric intake. This study inspired Dr. Sinclair to pursue his research on aging, where he has since found similar results in yeast. Theres a genetic pathway that gets triggered by low energy, says Sinclair. We consume less energy and activate enzymes called sirtuins by consuming fewer calories.

At his lab at Harvard Medical School, Dr. Sinclair and his team found that low energy activates sirtuins by causing our cells to make NAD+ (nicotinamide adenine dinucleotide), which sirtuins use as fuel. NAD+ was shown to increase the lifespan of yeast, which is one of the reasons why so many people now take NR (nicotinamide riboside) and NMN (nicotinamide mononucleotide) supplements, which boost NAD+ levels.

In addition to sirtuins, another molecule important for longevity is mTOR (mammalian target of rapamycin), except this one is better if not activated. Many animal studies show that decreasing mTOR increases lifespan. Sinclair explains that this is due to autophagy, where old proteins are recycled to make new ones. In humans, drugs that inhibit mTOR, like rapamycin, boost immunity and cause biochemical changes that mimic fasting and predict longevity.

The final longevity molecule discussed by David and Matthew was AMPK (AMP-activated kinase), an enzyme that goes up in response to low energy. One function of AMPK is to make more mitochondria, which decrease as we age and are vital for cell survival. In humans, the type 2 diabetes drug metformin activates AMPK and has been shown to reduce age-related disease.

We must fast to eat less often and regulate sirtuins, mTOR, and AMPK. Dozens of human studies have shown that fasting is beneficial for longevity. A Baylor College of Medicine study showed that fasting improved blood pressure, reduced BMI, decreased weight circumference, and, importantly, Sinclair says, upregulated DNA repair proteins. He explains that diseases like type I diabetes, multiple sclerosis (MS), and even cancer benefit from fasting.

Those three defense components [sirtuins, mTOR, AMPK] of the cell take care of the body, not just for aging, but to fight diseases in young people, middle-aged, and genetic diseases, says Dr. Sinclair.

David and Matthew go over three primary ways of fasting: the fasting-mimicking diet, intermittent fasting, and time-restricted feeding.

The fasting-mimicking diet involves lowering mTOR activity by reducing the consumption of branched-chain amino acids. For this diet, the time window for eating isnt as rigorous. Sinclair says, you want the body to be in a state of perceived adversity. He explains that in a clinical trial, the fasting-mimicking diet was shown to help cancer patients survive and get over chemotherapy quicker.

Intermittent fasting is going longer than a day without eating. This can go on for days or weeks, although Dr. Sinclair says, he wouldnt go longer because youll start chewing up your muscle. These long fasts turn on autophagy. Once youve gone beyond three days, your metabolism switches into whats called chaperone-mediated autophagy, the deep cleanse.

Time-restricted feeding, which involves not eating for at least 16 hours within 24 hours, is Dr. Sinclairs preferred fasting method. Sinclair explains that your liver will start making glucose at a steady level after a few weeks, so there wont be large spikes of insulin that put you in a glucose deficit and make you tired.

Which fasting method is best? David and Matthew proclaim the importance of genetics when it comes to fasting. A mouse study showed that caloric restriction shortened the lifespan of more mice (based on genes) than it lengthened. This means that caloric restriction probably does not work for everybody. Sinclair also says that fasting isnt easy, but its worth it. The trick, he says, is to fill yourself with fluids.

For me, constant coffee, tea, hot water, all the way through the day. Being hydrated and filled with liquid takes away any feeling of hunger.

In the last portion of the conversation, David and Matthew go over what we should eat to live longer. First, they go over what not to eat: sugar and meat.

Dr. Sinclair says that sugar is bad because it will reduce longevity, lead to type 2 diabetes, and possibly cause cardiovascular disease. It also shuts off AMPK and sirtuins. In other words, with high sugar, your defenses against disease and aging are minimal.

The Harvard scientist explains that red meat is non-beneficial. It is suitable for athletes or bulking up, but when looking at the evidence, high protein, carnivorous, red meat-based diets are not beneficial for a longer lifespan. High protein will shut off sirtuins, and the branched-chain amino acids in meat activate mTOR, inhibiting autophagy.

What should we eat? Dr. Sinclair himself is now a vegetarian if that tells you anything. Also, in the 2013 Adventist Health study, it was calculated that vegetarians live longer than non-vegetarians. Additionally, in a study on women, the Mediterranean diet (mostly vegetarian with some fish) decreased biological aging.

That fasting or eating the right foods, like the Mediterranean diet not just to slows down the ticking of the clock, but probably reverses your age is a mind-blowing concept, says Dr. Sinclair.

Why are plant-based foods good for us? Dr. Sinclair and Dr. Konrad Howitz published a paper in Nature showing that plants contain molecules called polyphenols, which activate the sirtuin enzyme Sirt1 and cellular pathways important for health and longevity.

As told by Dr. Sinclair, the takeaways of this podcast are to (1) eat less, (2) avoid sugar, (3) reduce meat intake, and (4) eat more of a plant-based diet, like the Mediterranean diet. He mentions that a study of elderly subjects in Spain showed that you could change your diet until the age of 80 and still get the benefits, so its not too late for many of us to change our eating habits to help us live longer lives.

Read more from the original source:
David Sinclair: How to Change Your Diet to Live Longer - NAD

David Sinclair gained a lot of popularity with his recent appearance on the Joe Rogan Experience, especially as he discussed such a poignant topic as life extension.

But is anti-aging something we can consider?

Can we fight death?

Not exactly. We can fight the negative effects of aging; we can look younger, and feel better for longer periods of time.

Thats Davids promise.

In the latest news, Sinclair, along with other European and US researchers has established the Academy for Health and Lifespan Research.

And, although hes 50 years old, his biological age is 31.

His antiaging research, his energy, and his focus, plus his appearance could convince anyone that what hes saying is legit.

However, remember to consult your GP before trying anything because all these products may interfere with pre-existing conditions.

RECOMMENDATION (Good For Daily Energy & Longevity)

In My Personal Experience & According to Countless Anecdotal Evidence It Provides Energy and Vigor Throughout The Day & Scientifically Shown to Raise NAD Levels. Now. (.).

David Sinclairs 1 gram of NMN and 0.5 g of resveratrol in the morning is mixed with yogurt; Studies showed that resveratrol absorption was 5 times lower if without fat. He doesnt mention a specific brand David takes the products below. He does take the resveratrol leftover from clinical trials. He prescribed some of these molecules to his mom and dad too, and even his family dogs!

Below are 3 longevity supplements David takes: Metformin, NMN, and Resveratrol, and more

NMN and Nicotinamide Riboside elevate your NAD levels. (Tru Niagen is The Best Replacement for MNM, it is considered to be more effective in raising NAD levels. I recommend considering Tru Niagen (Nicotinamide Riboside) products instead of NMN)

NAD helps your body make more energy. When you age, your cells make more NAD.

So not only do you feel more tired, your cells cant function properly because they dont have the energy they need.

Thats why David advocates supplementing with NMN to increase your NAD levels, even though theres no scientific consensus on this either.

David mixes his NMN into yogurt, so you need to find a powdered version.

Alive By Nature NMN Sublingual Powder is one of the best NMN powders on the market. Its 100% natural and vegan, with over 99% purity, no GMOs, and no gluten.

It works better if you place it under your tongue, though. The belief is that way the NMN can enter your bloodstream immediately, bypassing the liver, although this approach isnt fully researched yet.

The only downside is that quality NMN like this one is quite expensive, especially if you want to take 1g/ daily like Dr. Sinclair.

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Remember how everyone used to be hyped about red wine? Thats because of all the resveratrol found in the grape peel.

It was assumed that because grapes have this anti-aging substance in their peel, you can drink red wine and youll live a longer, healthier life.

Now we know thats not the case because youd have to drink hundreds of bottles of wine per day for resveratrol to work.

Thats how concentrated resveratrol supplements emerged. That is controversial, but well discuss that below.

We, the plebe, have to look on Amazon. To make sure you get a product thats similar to what he is using, you can read a paper published by one of his companies, Sirtris Pharmaceuticals, which was testing micronized resveratrol.

Micronized resveratrol increases the blood resveratrol levels almost four times.

As per these podcasts notes at Rich Roll, he recommends RevGenetics M98 Micronized Resveratrol. This is a legit company that has been selling resveratrol supplements since the early 2000s.

This product is micronized, so the molecules last longer in your bloodstream.

The powder form is user-friendly, as you can mix it with your shakes or yogurt.

With a 98% purity and high potency, the only downside of this supplement is how much it costs.

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Vitamins D3 and K2 are both involved in proper calcium absorption in your body. That way, calcium can go straight to your bones instead of blocking your arteries.

Sports Research Vitamin K2 + D3 with Organic Coconut Oil is one of the best choices that I discovered.

These concentrations mean that each capsule is very potent and efficient.

Keep in mind that the DRA for vitamin D3 is 600-800 iu per day, but vitamin D3 is easily excreted through the urine, so you need a bigger supplementation.

Even so, consult your GP before taking a D3 supplement, especially if you have pre-existing conditions.

Your GP might prescribe anywhere between 1000 iu to 5000 iu daily.

That said, this supplement:

The only con is possible bloating, but thats just the effect of D3. This supplement from Sports Research causes fewer GI problems than other D3 supplements on the market.

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Metformin is not a new appearance in the pharmaceutical market. Medical practitioners have known about metformin for a century, and they began studying it in the 1950s.

A plant-based drug, metformin is extracted from French Lilac, and its used in managing diabetes, considering it can decrease blood glucose.

Considering that metformin has all the advantages, and none of the risks, its no wonder that it looks appealing to fight aging.

All the other anti-aging products are nowhere near this tested and with so much patient-related data.

Can metformin fight old age?

Metformin is involved in the AMPK cellular pathway activation, which leads to:

Metformin can improve your metabolism, keep your cells healthy, and eliminate unhealthy ones.

However, metformin is a prescription drug, and most doctors prescribe it only for type 2 diabetes, not for general health and longevity.

Dr Peter Attia write on metformin and exercise. Really interesting. Do not take it the same day/time as your exercise!!!

In a podcast with Joe Rogan, he says hes been taking statin since his twenties because he has high cholesterol in his family.

Statins are prescription drugs that:

Side effects include:

These side effects are more common for over 65-year-old females and people with diabetes.

Statins interact with grapefruits, which block certain enzymes that help your body metabolize statins.

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Dr. Sinclair explains how NMN supplements work in a Joe Rogan Experience podcast.

He explains that diseases and age-related deterioration are caused by certain genes, called sirtuins.

NMN (nicotinamide mononucleotide) is a type of molecule that activates sirtuins, meaning NMN supplements can prevent disease, give you more energy, and reduce the negative effect of aging.

NMN boost NAD levels, and sirtuins need NAD to work properly.

NAD, aka nicotinamide adenine dinucleotide, is a coenzyme that assists your metabolism, so your cells have more energy to function and to fight diseases.

People cant take NAD directly because its a larger molecule that cant be metabolized easily. NMN is smaller, so its easier to absorb.

David has been taking 1g of NMN/ day for the last three years.

Studies show that the risk-free dose is 1-2g/ day. Some side effects can include mild GI distress, tiredness, and light headaches.

Benefits:

Apart from taking all of the products mentioned above, David does intermittent fasting. He mentions both on his blog and in his book called Lifespan: Why We Ageand Why We Dont Have To that you can live longer if you dont overeat.

He believes that old age is a disease that can be treated through nutrition. Intermittent fasting and calorie restriction improve your metabolism.

As such, your cells have more energy to keep the healthy ones alive and to kill the unhealthy ones. Accelerated metabolism also reduces inflammation and oxidative stress, which have been linked to chronic diseases.

David also exercises frequently:

David recommends using sauna and cold baths together, to accelerate your metabolism and improve heart function.

While David generally tries to get all the vitamins and minerals he needs from his diet, he does still take some supplements daily. Specifically, hes talked about taking:

In Davids book Lifespan, he mentions taking vitamin D3 daily. Vitamin D is a vital micronutrient and is thought to exercise an important effect on at least 200 of our genes. Its relatively scarce in foods, and so we rely on sunlight for producing adequate quantities. If youre not getting much sunlight, then it can be necessary to supplement it.

David doesnt name on the record what brand he uses, or how much he is taking, he discusses in the podcast with famous Dave Asprey that he needs 2,000iu per day at the minimum.

David suggests taking Vitamin K2 in his book.

Vitamin K is a crucial micronutrient that performs a vital role in the capacity to form blood clots and to move calcium throughout the body. It comes in two various forms, K1 (phylloquinone) and K2 (menaquinone). K1 is the most plentiful in a western diet, found in leafy green vegetables. Vitamin K2 is located in fermented foods, which are less prevalent in a western diet. A source thats unusually high in K2 is fermented soya beans.

Sadly, many people are low in K1, and hence may have low levels of K1 to maintain sufficient calcium transport

So where does the vitamin K2 supplementation come in?

Vitamin K1 is used in the liver, and K2 appears to be prioritized for use in the periphery, which will support calcium transport.

David suggests taking alpha-lipoic acid. Not to be confused with alpha-linolenic acid that is a source of omega-3 fatty acids, frequently found in seeds. Alpha-lipoic acid is found naturally in a specific food, and when ingested, is used in the cells as a cofactor in mitochondrial energy metabolism.

David states in the interview with David Asprey that he gets Coenzyme Q10 due to the fact that he is taking statins. He doesnt explain why he takes Q10, but hes likely referring to a study that proposes that statins may decrease coenzyme Q10 levels in the blood. He just states that he gets a large pill daily. Q10 supplements are generally taken in the 100 to 200mg range.

Davids diet is shaped by his caloric restriction principle. He also avoids foods that impact metabolism and affect the glycemic index.

As weve mentioned before, NAD is a helper molecule that fuels some of the most important biological processes in your body, like:

NAD levels plummet with old age. Very low NAD levels are correlated with Alzheimers, diabetes, cardiovascular issues, and vision impairment.

Thats why taking NAD precursor supplements like those manufactured by Metro Biotech can help you age gracefully.

In the words of David, resveratrol steps on the accelerator pedal of the sirtuin enzymes.

In the same JRE podcast cited above, David explains that there are plenty of mice studies that show resveratrol improves their health/longevity and lengthens their lifespan.

David says that you need NMN for resveratrol to work because NMN is the fuel that sirtuins need. You cant accelerate sirtuins if they dont have enough energy to work.

The problem with sources is that NMN is not naturally occurring. The human body normally makes glycine, a type of amino acid that is similar to the NMN in order to produce energy. While there is a relatively small amount of glycine in our body, there is sufficient to produce a very mild, long-lasting antidepressant effect, but not enough to produce a noticeable improvement in mood. Similarly, those seeking a more powerful NMN effect may want to look at the pharmaceutical brands that are available, such as Evista recommended by Rhonda Patrick. In many ways, NMN is similar to the way that omega-3 fatty acids can reduce inflammation in the body. While we can consume the omega-3 fatty acids ourselves, the body cannot make NMN on its own and thus must rely on diet and supplements to obtain them. To supplement with NMN, it is best to start with a relatively low dosage of less than 100mg per day, which you can digest without the body having to break it down into a different form.

Ways to get a glucose-lowering effect from eating plant foods. A good habit to incorporate into your lifestyle is consuming protein with each meal. Protein promotes weight loss by increasing metabolism. For most people, a combination of protein and plant foods is most effective for weight loss. In addition, to help minimize carbohydrate cravings, a protein snack can be a good idea every 3 hours. I know of several things that have helped people get some lower-glycemic foods in their diet. Some of these include: Tracking and logging food intake. Dietary fats and protein control. Eating organic foods. Fiber. Lots of vegetables. When working with clients, I like to remind them that weight loss and health are better than any kind of diet. Even a diet that may seem good on paper is not good for long-term health. You cant fix your overall health with a diet unless you add exercise, physical therapy, and other lifestyle modifications. It takes a lifestyle change to heal, and a diet wont necessarily do that.

Evidence that dietary Nicotinamide mononucleotidesupplementation with nicotinamide riboside (NR) might be an effective strategy for modulating glucose-6-phosphate cycle kinase in type 2 diabetes has sparked a great deal of enthusiasm.2,4,10,15 In particular, clinicians have been encouraged by the recent findings of Lozada et al8 who found that NR supplementation (3 g/day) significantly improved glycated hemoglobin (HbA1c), glucose tolerance, and fasting glucose (BG) in individuals with impaired glucose tolerance (IGT), following 10 weeks of treatment.3 Other recent trials have shown NR is an effective strategy for insulin and glucose control in T2D and type 1 diabetes in children, adolescents, and adults,3,4,6,10,12,14,1519 and has also been found to have beneficial effects.

Folk medicine suggests that the consumption of bonemeal can help the body fight age and protects the organism from diseases. They are popularly called bioneers in India. Some research has also revealed that this substance can slow down the progression of heart and blood vessel diseases and can even prevent the occurrence of high blood pressure. Even more than that, the people who are consuming this low-calorie food have also been found to be able to lower their risk of cancer.

Given the above-mentioned facts, you should definitely take a closer look at the ginseng and beechwood extracts. According to a new study published in the journal Nature Medicine, they have the ability to extend the life of rats by 30 percent. In addition, the rats that were given a mix of these ingredients have also shown a reduction in the number of carcinogenic compounds in their urine, cholesterol levels, and even blood sugar. So, how exactly can these substances prolong our lifespan? Well, they contain compounds called flavonoids. They protect your cells from damage and have anti-inflammatory and antioxidant properties.

Were learning more about the health of the body in order to become the healthiest, leanest, and happiest that we can be. The truth is, we really dont know all that much. The human body is the most complex machine in the world, and to fully understand and reverse aging, wed need to understand the secrets behind every single aspect of the process. However, thats not the case. 1 cup of coffee in the morning, green tea after that. This I especially troubling to many because it means that as we age, we continue to experience a body that grows more complicated in order to stay functional for longer than we would like. One fact of the family history is for certain: for as long as the human race is on this planet, it will need to know about the body.

If the body gets sick, it keeps us alive. It takes care of us. One of the best ways to achieve health, happiness, and longevity is by strengthening the body and nutrition. Consider the health benefits of eating an alkaline diet. Benefits of an Alkaline Diet. Simply put, an alkaline diet is a diet that is alkaline in nature. This means that you are eating foods that arent too acidic. As we age, our bodies become more acidic which can be caused by inflammation.

Trying to think of ways to enhance your health by taking a supplement of something is certainly great, but it also usually comes with a risk that youll be able to make a very good excuse not to take the vitamin or supplement in the first place. Now, there are situations when it is advisable to take two or more supplements at the same time, but most of the time, you should try to limit your supplement with methyl groups to only one of them, or maybe, the supplements are supposed to work as a combination.

If you are taking another supplement, be careful to take it at the same time, preferably at the same time every day, if not right after you take your first supplement. A lot of different types of vitamins can affect each other, and if you put them together, they can become more effective than they would be on their own.

Yes, the medical consensus is that resveratrol is safe.

However, theres no consensus on whether or not it works.

In 2006, he co-wrote a paper on the benefits of resveratrol. Resveratrol is a stilbenoid found in the skin of grapes in low amounts. Studies have shown that resveratrol can reduce the risk of heart disease, cancer, and neurodegeneration. David Sinclair believes that resveratrol works synergistically with NMN. Resveratrol is needed to activate the sirtuin genes.

Excerpt from:
David Sinclair Supplements (2022 List) | Brands for Anti-Aging!

The new authorized biography of late Rolling Stones drummer Charlie Watts was launched at a special event on Friday night (16) at south Londons Sound Lounge venue.

Charlies Good Tonight: The Life, The Times and the Rolling Stones, by music writer, broadcaster, uDiscover Music contributor, and longtime Stones chronicler and interviewer Paul Sexton, has the approval of Watts family and is endorsed by the band themselves.

It features forewords by both Mick Jagger and Keith Richards and a prelude by former band manager and producer Andrew Loog Oldham, and was published in the UK on Thursday (15) by Mudlark/HarperCollins. US publication follows on October 11, after which it will be out in the Netherlands on October 24, Spain in November and numerous other countries next year.

The launch evening combined live performances with audio and video celebrating the life and work of one of the most admired musicians in the worlds of both rock and jazz. A core live band featured guitarist and Sound Lounge co-founder Keiron Marshall, bassist Terry Peaker, and drummer Nigel Appleton, with guest appearances by David Sinclair, leader of his own David Sinclair 4; rock singer Helen Hurd; Danny George Wilson, of UK Americana Award-winning bands Danny and the Champions of the World and Bennett Wilson Poole; and his frequent collaborator on guitar, Paul Lush.

The location of the venue, one block away from the pub in Sutton formerly called the Red Lion, where the Stones played many early gigs both before and after the arrival of Watts and Bill Wyman in the line-up, was reflected in the opening live tracks. Chuck Berrys Bye Bye Johnny, with lead vocals by Sinclair and also featured on the DS4s new Apropos Blues album, was on the Stones first, self-tjtled EP in January 1964; Slim Harpos Im A King Bee, with vocals by Marshall, was on the groups debut album three months later.

Later tracks performed on the night included another Berry composition, Let It Rock, again featuring Sinclair; Time Is On My Side and Mixed Emotions, both with Wilsons lead; Tumbling Dice, featuring Hurd, and a closing return to the Stones R&B roots with Ride Em On Down, the Eddie Taylor song covered by the band on their chart-topping 2016 album Blue & Lonesome.

Interspersed with the live performances were tracks from albums by the Stones and from Watts various jazz projects, selected videos, and excerpts from Sextons interviews with the band, whom he has been interviewing since the early 1990s. Guests at the event, featured in the book, included Watts tailor and shoemaker respectively, Dario and John Carnera, and Nettie Baker, daughter of Ginger, with whom Charlie had a lifelong friendship.

Listen to the best of the Rolling Stones onApple MusicandSpotify.

See original here:
Authorized Biography Of The Rolling Stones Charlie Watts Launched In London - uDiscover Music

While David Sinclair might be best known for his shorter-distance mountain running, his second place at the 2022 Canyons by UTMB 100k shows his competitive diversity. In our first interview with him, David gives us the blow-by-blow of his all-race duel with Adam Peterman, the experience of sharing his Western States 100 Golden Ticket with fourth-place Rod Farvard, and where else well see David compete in 2022.

For more on what happened at the race, check out ourCanyons 100k resultsarticlefor the play-by-play and links to other post-race interviews.

iRunFar: Meghan Hicks of iRunFar. Im with David Sinclair, the second-place finisher of the 2021 Canyons Endurance Runs by UTMB 100k. Hey, David.

David Sinclair: Hi, Meghan. Thanks for being out there and covering the race today.

iRunFar: Yeah. That was really fun. We usually try to do these interviews in person, but you live over the pass in Sierra Nevada and you went home and scrubbed the poison oak off your legs after the race.

Sinclair: Yeah. Im pretty beat up and wanted to get home and shower.

iRunFar: When you live that close, I would go too.

Sinclair: Yeah, its pretty nice to have it right in the backyard there.

iRunFar: Yeah. You had a heck of a race today. How do you feel about it?

Sinclair: Im pretty ecstatic at how it went. Its always tough moving up in distance. Id never raced over six and a half hours and 50 miles before. So, this was the most vert and just the hardest, most competitive ultra Id been in. So I was really psyched when I ran strong pretty much the whole way. We were running well under course record pace the whole first two thirds of the race. And I kept thinking, I know this is going to catch up with me eventually. And it did right about halfway up the Deadwood climb. I started tightening up and had a couple little dark miles as I was thinking maybe Im going to cramp up and have to just walk it all the way in. But I was able to hang on pretty well.

iRunFar: So, talk a little bit about the beginning of the race. Its one of those dark starts flying off the line, flying through the early morning type thing and the terrain is pretty runnable early. So maybe give us the rundown of the first 15 or 20 miles.

Sinclair: It was just a huge group, but right from the start 20, 25 guys Doing six-minute miles out there and its just pretty runnable, gradual downhill, that first four. And so my original game plan was to hold back and be patient, but I was feeling pretty good, so I found myself never too far off the front. Feeling good, trying to keep it in check a little bit. So it was a fun, big pack. A few people were getting ahead on the climbs and I find Im a pretty good downhill runner, so I kept getting a little behind on the early climbs and working my way back up on the rolling and gradual downhills. But it felt just really comfortable. It was fun to run in a group and just absolutely gorgeous morning with the cool weather and nice fog. Its cool as you get up above the river to look down. So just really fun running through Drivers Flat there.

iRunFar: Im really glad you got to see that scene because for us spectators, that fog in the American River Valley, and the sunrise, and the moon, was just unreal this morning.

Sinclair: Yeah. I couldnt ask for a better day for a race. The rain down there actually made it really nice, runnable. It didnt seem too muddy at all, and just crisp and cool, which was the nice thing for me. Because I living up in Truckee, I dont think I had maybe three runs that have been above 60 degrees so far this year. So it was a real blessing to have it be a nice, cool day.

iRunFar: Awesome. I think there was still a pack of five or six of you guys at Cal 2, 24 miles into the race, but then things really splintered on the climb up to Foresthill. Can you talk about that part from your point of view?

Sinclair: Yeah, it was a pretty close pack and I was running I found myself in the front through Drivers Flat, running with Adam Peterman and I think it was Daniel [Jones] from New Zealand and Adam was feeling good, so I let him do most of the leading and took the lead a couple times on some of the hills where I was feeling good. I was saying, Why not? At that point, I still felt really good, lets see what we can do. And we, working together, finally opened up a gap there into Foresthill. And I pushed right through without stopping at the aid station Foresthill, and finally found myself in the lead for a little bit. So down to the river crossing there, I could see Adam was just 30 seconds behind me.

Sinclair: And so, I pushed it up to Michigan Bluff and got a little bit of a lead there. And then finally about mile 40 coming to the Deadwood aid station, I started just tightening up and I look back and theres Adam again. And I go, Oh no. There goes my shot at the win. And he came just flying by me. So that was the darkest patch of the race there, the climb past the Deadwood aid station.

Sinclair: We hit snow for the first time and it was sloppy for a mile. And then I finally got a second wind on the way down, but I was really hurting the last 12 miles. So, luckily I had stashed some trekking poles in my drop bag at the Deadwood aid station and with the legs on the edge, I grabbed those trekking poles and just tried to use my arms as much as I could to get up the last nine-mile climb, which just felt like it kept going on and on. And I had no idea, I kept getting splits that I was 5, 8, 10 minutes back on Adam. And I was like, Okay, just keep on moving and try to hold on to second.

iRunFar: And it never became an issue of anybody behind you. Nobody ever Jared didnt get close, I dont think.

Sinclair: He was pretty close at the end there. I was never really getting any good splits. So I had no idea how close he was.

iRunFar: You were running a little scared or

Sinclair: I was just running as far as I could without The last four miles there, back in the slush, it was these icy cold puddles and your tight legs. So, the icy cold water, youre like, How hard can I go without making my legs totally seize up? So I never really looked back. I just kept my head down and kept using my arm as much as I could to get to the finish and kept getting, Okay, its two miles to finish. I think I can do this. I think I can do this. And then, it felt like it was a minute or two and he came across and I was like, Oh, that was closer than I realized. If there was much further, I think he wouldve had me.

iRunFar: Interesting. A lot of people came to this race in search of a Golden Ticket, but there was a really cool moment at the finish line where you demured a little bit about the ticket and then you handed it over to fourth place finisher Rod Farvard. So you were not seeking a Golden Ticket at this race, you were here for other things.

Sinclair: I mostly wanted to do it because its in my backyard, its such a cool, competitive race. To get a little experience moving up to a 100k and try it out was my main goal. And I knew that I had a shot at top three and I was like, Oh, its tempting. I definitely want to run in Western states in the future, but Im already planning to try to run the Broken Arrow races, even closer to my backyard, three miles down the road. And maybe going to try to go to Europe and run Marathon du Mont-Blanc. So, Ive got a bunch of cool things on the calendar.

Sinclair: So, I think Western States will have to wait. And so when I saw Rod come across the finish line having an awesome race I think hed passed one or two people on the final climb to move up into fourth and hes really wanting to run Western States. So when I saw that I was like, This is the right thing to do. I dont need to go home and think about it for two weeks. And its the right decision for me to wait. Hopefully in the future, Ill be able to get into Western States and give it a real shot.

iRunFar: That was a really cool moment. It was win-win for everybody and it was a really fun to spectate that type of thing. You dont always get to see that type of interaction. That was really cool.

Sinclair: Yeah. As soon as I did it, I knew it was the right call to see the smile and the joy in his face. So, I was based on how I felt coming across the finish line, I was like, 40 more miles plus. Im not someone who likes the heat, so I dont know. Yeah. But good luck to Rod. Ill be rooting for him.

iRunFar: Thats awesome. Last question for you. You said instead of States, your 2022 is going to include the Broken Arrow races, Marathon du Mont-Blanc. What else are you going to do this year?

Sinclair: Yeah, everythings a little up in the air. Kind of depends how the legs come around and how everything is feeling. I might do the Speedgoat in July, its one of my favorite real mountain races, so signed up for that. And then Ill probably try to finish the three races out of the Golden Trail Series. So, since there are two in the US this year, thats a great opportunity. So, Im going to try to do the Pikes Peak ascent and then the race down in Flagstaff, Sky Peaks. So those are the big ones on my agenda. Might apply or try to see if I get a spot on the Worlds [World Mountain & Trail Running Championships] team too.

iRunFar: Right on. You got a busy year.

Sinclair: Yeah. So lots of races on the calendar. So, theres lots of great races to do.

iRunFar: Plenty to do. Well, congratulations on your second-place finish at Canyons 100k today. That was really fun to watch.

Sinclair: Thanks so much, Meghan.

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David Sinclair Post-2022 Canyons by UTMB 100k Interview - iRunFar