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Category Archives: Anatomy
Anatomy Of A Fall star Messi getting Cannes show – The A.V. Club
Messi at the Oscars Photo: Rob Latour ( Shutterstock )
Hollywood will do anything to avoid paying a real human, actor, huh? Just kidding! We are all very happy for the success of Messi the dog, who was the breakout star in the Academy Award-winning French film Anatomy Of A Fall. According to IndieWire, the canine actor is capitalizing on his success with a new series called Messi: The Cannes Film Festival From A Dogs Eye View.
Maksim Chmerkovskiy on "So You Think You Can Dance" and meeting John Travolta
Messi, a.k.a. the canine George Clooney, as producer D18 Paris calls him, will host the series of eight episodes, each running one minute. According to a statement from D18 (via IndieWire), This will be an opportunity for Messi to ask his guest any questions with the innocence of a dog. When youre the current international star, you can do anything and Messi dares to do it all!
Surely, Messis team didnt mean to paraphrase Donald Trump on the infamous Access Hollywood tapes? What kind of nefarious shit will Messi be getting into over at Cannes? He already caused enough of a stir by allegedly unfairly swaying the vote in Anatomys favor by being a Very Good Boy at the Oscars Nominee Luncheon, nearly getting himself banned from the Academy Awards ceremony. He doesnt need to give the studio system any more ammunition to have him canceled and put out to pasture. Better keep him away from any cats, just in case.
All jokes aside, Messis show is a French program running on French channels (France 2, France 3, Culturebox, and TV5 Monde) from May 13 through the end of the festival, March 25. However, its sponsored by TikTok, so youll probably see it online somewhere. (You still have several months of the app before the ban goes into effect.) Tim Newman, who conceived the series, will produce for D18, while Raphal Mezrahi, who incarnated the show, will write and provide the voice of Messi. Loc Pourageaux will direct, and then of course theres Laura Martin, Messis loyal trainer.
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Anatomy Of A Fall star Messi getting Cannes show - The A.V. Club
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‘Grey’s Anatomy’: When Did Fans Stop Hating and Start Loving Amelia Shepherd? – The Daily Beast
The Greys Anatomy fandom has never lacked for controversial characters. In fact, Grey Sloan Memorial Hospital seems to hire specifically for that quality. That said, I must ask: Have we ever seen a character redemption arc as pronounced as Amelia Shepherds (Caterina Scorsone)? Once perhaps the worst character wandering this hospitals hallowed, absolutely uninsurable halls, shes spent 13 seasons and counting becoming one of its most compelling.
ABCs chief medical drama is all about stirring up our emotions and, sometimes, our angry keyboards. From the ever-complicated Meredith Grey (Ellen Pompeo), to the lovable but rarely logical Izzie Stevens (Katherine Heigl), to the well-meaning but absolutely toxic lover Owen Hunt (Kevin McKidd), Amelias peers have all had their less-than-stellar moments. For a while, however, everyone in the fandom seemed to hate her with a burning passion.
Maybe it was her ongoing competition with Derek that put people off, or maybe it was her short temper, but the hatred has been intense. Those whove been hanging out with Amelia since her time on the Greys spin-off Private Practice might have a deeper appreciation for her absurdly traumatic backstory. (For those who need a refresher: She watched her dad get murdered when she was just 5 years old; as an adult, she woke up one morning to find her fianc dead from an overdose beside her; and she carried her son to term knowing he would not survive, just so that his death could become meaningful through organ donation.)
That said, some viewers simply could not stomach Amelias impulsivity, her horrific behavior in pretty much all of her romantic relationships, and her admittedly kinda corny superhero pose. To each their own!
But what changed? During the shows most recent episode earlier this month, I saw multiple posts about Amelias princessing. This was where my curiosity began. Then, I dove down a deep social media rabbit hole and started watching the fan videos on YouTube. A theory began to take shape.
It should come as no surprise that a big part of Amelias appeal seems to come down to Scorsones performance. Amelia is bold and expressive, if often self-centered, and while plenty of Greys actors have seemingly started phoning it in over the years, Scorsone always comes ready to Act with a capital A, adding small flourishes to her delivery that make all of Amelias lines feel like Amelia-isms. It also doesnt hurt that a lot of people simply think that Scorsone herself is pretty adorable and also cool as hell. (If only all of us could hang with Hayley Kiyoko!)
Then, theres Amelias actual arc, which, when you take a step back and look at it, has also been a pretty redemptive one. Shes overcome multiple potentially devastating experiences and uses her experience managing her addiction to support colleagues like Dr. Webber when theyre struggling. Also, not for nothing, she saved Geena Davis life (OK, Dr. Hermans life) through an impossible brain surgery that pretty much no one thought she could pull off. Later, she herself survived a brain tumorfurther solidifying her resilience for any remaining haters and losers who mightve doubted her.
Sure, Amelias relationship with Owen was kind of a mess, as are most of her romantic relationships. And yes, she handled that whole paternity test situation with Link (Chris Carmack) all wrong. And yes, OK, she can often struggle to take accountability during interpersonal disputes. But none of us are perfect, right? On a show like Greys Anatomy, especially, where everyone has their disastrous moments of disgrace, being a fuck-up is always kinda relative.
Come to think of it, maybe one of the biggest reasons for Amelias rise from the deepest depths of most-hated territory is that shes actually stuck around long enough to grow on people. On a storytelling level, the massive turnover weve seen on Greys likely also plays a role here. At this point, 20 seasons inGod, does that make me feel old to typeAmelia is one of the longest-running characters we see on screen each week. Apart from Meredith, who only pops in periodically, our only remaining original characters are Chandra Wilsons Miranda Bailey and James Pickens Jr.s Richard Webber.
When people come and go so often, theres some inherent comfort to seeing someone youve spent a lot of time with alreadyeven if she used to annoy the hell out of you. Lets just hope that if she really does get with Natalie Morales Monica Beltran, she gets out of her own way and lets us all have the ship we deserve.
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'Grey's Anatomy': When Did Fans Stop Hating and Start Loving Amelia Shepherd? - The Daily Beast
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Interstitium: A Network of Living Spaces Supports Anatomical Interconnectedness – The Scientist
The human body is enmeshed in an intricate internal web of living spaces known as the interstitium.1 These fractal-like structures create a vast honeycomb network of fluid-filled openings within and between tissues and organs that spans the body and acts as a thoroughfare. A sophisticated system of connective tissue, including collagen and various other extracellular matrix proteins, supports the continuity of this network. The interstitium is increasingly being recognized as a fundamental anatomical structure and body-wide communication system.
The discovery of the interstitium in 2018 made waves, with many questioning whether scientists had discovered a new organ.1 It's actually not an organ. It's a system, said Neil Theise, a medical doctor and professor of pathology at NYU Grossman School of Medicine, whose team made the discovery. The space itself may be as large as 100 to 200 microns. It's grossly macroscopic, you can see it when you look at any connective tissue in the body, and you can pull it apart with tweezers. Thats not because the collagen easily shreds, but because it's actually a net, said Theise.
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There is a Crack in Everything; Thats How the Light Gets in
Neil Theise is a medical doctor and professor of pathology at NYU Grossman School of Medicine.
Beowulf Sheehan
Remarkably, doctors and scientists routinely encountered the interstitium but were taught to ignore it. Surgeons regularly removed and discarded portions of this body-wide net and pathologists wrote it off as an artifact of tissue processing. In the latter case, preparing tissue samples for microscope viewing involves a series of steps that include fixation and dehydration. The fluid is removed from the spaces of the interstitium, and the structures collapse down on themselves. You see these cracks, these little openings in the collagen, Theise said. For decades, what Ive been taught and what Ive taught people is just ignore that because collagen is so stiff that when you try to section [the tissue] it cracks. When Theise and his colleagues made their ground-breaking discovery in 2018, they realized that the spaces in living tissue corresponded with the cracks routinely seen in fixed tissue sections on microscope slides. It turns out those are the remnants of the living spaces, Theise said.
With this realization, the cracks in contemporary science and medicine were exposed. Despite the vast scientific knowledge that exists about the human body, the picture remains profoundly incomplete. But as poet, singer, and Zen Buddhist Leonard Cohen famously sang, There is a crack in everything, thats how the light gets in. The interstitium may be the missing piece of the puzzle that helps explain the interconnectivity between every cell, tissue, organ, and hidden crevice in the body. There isnt a tissue that isnt riddled with the spaces. The interstitium has the ability to communicate through the body across every scale, from the quantum electromagnetic level, all the way up to the cellular level, Theise said.
Because the interstitium is a fibrous network, mechanical stimuli that affect a fiber in one area also affect other regions of the body, creating a network of mechanical connectivity. "If you want to communicate a signal, mechanics are so efficient, said Andrew Pelling, a professor of physics and biology at the University of Ottawa. It's no surprise that there are all these highly evolved systems to sense and transmit mechanical information."
Theise explained further that the collagen that makes up the interstitium is piezoelectric.2,3 It can convert mechanical force into electrical currents that may carry charged molecules through the interstitium. Collagen, when you stack it up high enough, becomes a piezo crystal. Any movement of the collagen will generate electrical energy, Theise said. This may have far-reaching implications from tissue and organ regeneration to gastrointestinal function.4-6
The interstitium is continuous throughout tissue, in this case, the human pancreas, as well as the entire body. The image on the left shows a cross section through the draining duct of a human pancreas surrounded by thick bundles of supportive collagen networks in red. On the right, a hyaluronic acid stain in brown demonstrates how the interstitial spaces between the collagen bundles and filaments are filled with hyaluronic acid.
Neil Theise
The interstitium also acts like a sieve in other ways. The spaces of the interstitium are filled with hyaluronic acid, which has a high capacity to hold water, creating a gel. Hyaluronic acid is also highly charged, meaning it can preferentially allow access to certain molecules depending on their charges. In doing so, the interstitium has the potential to modulate the movement of large and small molecules, as well as cells. Although it is not clear how and where they move, the mechanisms may relate to signaling molecules like growth factors, chemokines, and cytokines that create chemical gradients to guide movement. This is particularly relevant for cell migration in the context of cancer cell metastasis through the interstitium.7 I can show you a tumor marching through these spaces, Theise said, referring to histopathological tissue slides of cancerous tissue. The interstitium is also believed to be involved in sepsis and fluid balance.8, 9, 10
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You Can Add up the Parts, You Wont Have the Sum
The Buddhist tenet of interconnectedness plays a strong role in Theises life and work. A practicing Zen Buddhist, Theise described the interstitium and his work as a pathologist in almost mystical terms. My Zen practice is about cultivating beginner's mind, to just be witness to the present moment and not attached to preconceived notions, not anticipating what you think you know will happen. My practice of pathology uses the same method, which is probably not a coincidence.
Science and spiritual practice came together unexpectedly for Theise one day during a particularly distracted meditative practice. He was ruminating on whether the body is a unique entity or a conglomeration of cells, when he noticed an incense stick turn to smoke on the altar. Suddenly, there was an instant bridge between the scientific and spiritual side in a way I was not looking for. But once you see it, youve seen it; like once youve seen the interstitium, you cant unsee it, he said.
The interstitium was long overlooked by surgeons and pathologists as a byproduct of biology and tissue processing.
Yet the interstitiums extraordinarily complicated net is far from easy to visualize. Theise and his colleagues have broken down the task, mapping the interstitium organ by organ to reveal the continuity of spaces within and between tissues and organs.7 In doing so, Theise also creates interconnections across scientific and medical subspecialities. "It makes sense to me, at least conceptually, that it is such an important space. It's everywhere, it's the interface between all of these discrete systems, Pelling said. Biology doesn't tend to create structures that are not important in some way. It's the same as those older notions about junk DNA that are starting to crumble. Biology is extremely efficient."
Contemporary science is successful because of its reductive approach. The human body is, in many ways, like a finetuned machine. But, as Cohen sang,you can add up the parts, you wont have the sum. Understanding how the interstitium works will define more of the rules about how the trillions of cells in the human body communicate across vast distances to create the exquisitely complex system that is the body. How these things all add up are vast scientific questions that will require a meticulously reductive approach as well as cultivation of a beginners mind. If you do any kind of work with dedicated focus, the secrets of the universe are there in what you're doing, Theise said.
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UNF students learn the art and science of printing 3D medical models – The Florida Times-Union
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UNF students learn the art and science of printing 3D medical models - The Florida Times-Union
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Messi the Dog From ‘Anatomy of a Fall’ Is Getting His Own TV Show – Collider
The Big Picture
The French film Anatomy of a Fall received five nominations at the Academy Awards, but it was another aspect of the film that has kept everyone talking about it: Messi, the Border Collie who starred in Anatomy of a Fall. Messi's performance was highly lauded as one of the best animal roles ever put on-screen, and now the four-legged actor is going in front of the camera again. Messi will star in his own television show set at the upcoming Cannes Film Festival, IndieWire reported. It seems that this year's installment of the iconic festival will truly be a dog-eat-dog world.
Messi's show will be set at the festival, fitting as Messi himself was born in France and lives with his handler near Paris. The show will actually be a short program that allows viewers to see themselves through the eyes and, somehow, the voice of Messi, according to Cannes production company D18 Paris. Details remain slim, but the show will reportedly run from dawn to late night and "will be an opportunity for Messi to ask his guest any questions with the innocence of a dog," D18 said. "When youre the current international star, you can do anything and Messi dares to do it all!" the production company added.
The show, which is officially called Messi: The Cannes Film Festival from a Dogs Eye View, will be a series of eight one-minute episodes and will be broadcast on a variety of French TV channels. The idea for the show came from Tim Newman, who will produce the show for D18, while Loc Pourageaux will direct. Raphal Mezrahi will provide Messi's voice.
Anatomy of a Fall featured standout performances from Sandra Hller and Milo Machado-Graner, but Messi became a superstar in own right when the film was released in 2023. Messi portrayed Snoop, and he stole the film during a scene in which he must act as a dog that has overdosed on aspirin, before Sandra (Hller) and Daniel (Machado-Graner) step in and perform life-saving measures. Though he may be just a dog, Messi's performance got everyone in Hollywood talking, and while the film itself became an Academy Award nominee, Messi won a special prize himself: the 2023 Palm Dog, given out by Cannes to the best dog performance of the year.
Messi became such a star that he even attended the Oscars for a brief period, despite initial reports that he wouldn't make an appearance. The dog filmed a series of reaction shots prior to the start of the ceremony, and Oscars host Jimmy Kimmel even mentioned Messi's popularity during his opening monologue. A clip of Messi appearing to "clap" for other nominees also went viral.
Messi's show will run for the duration of Cannes, from May 13 to May 25. Anatomy of a Fall is streaming now on Hulu.
A woman is suspected of her husband's murder, and their blind son faces a moral dilemma as the sole witness.
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Messi the Dog From 'Anatomy of a Fall' Is Getting His Own TV Show - Collider
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