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‘Intangibles’ examines team chemistry, with help from Barry Bonds and Jeff Kent – The Athletic

One of the glorious things about Joan Ryans new book is how often her interview subjects tell her that her premise is utter baloney.

Willie Mays scolds her.

Chemistry? Chemistry. Theres no chemistry!

Jeff Kent scoffs.

Listen, the best players are some of the biggest pricks to ever play the game. The biggest assholes. Selfish. Greedy.

Jim Leyland takes another puff from his cigarette.

To me chemistry was a subject you took in school. I had teams thatd go to chapel together every Sunday and couldnt win a game. So that dont mean shit to me. Forget chemistry out here.

Ryan, a nationally award-winning journalist who is now a media consultant with the Giants, welcomes the skepticism. Thats the point of this whole enterprise, to sort through the fact and fiction of what locker-room camaraderie or lack thereof might mean to...

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'Intangibles' examines team chemistry, with help from Barry Bonds and Jeff Kent - The Athletic

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Will the New Orleans Pelicans off-court chemistry matter more in closed campus? – Pelican Debrief

Brandon Ingram #14 of the New Orleans Pelicans (Photo by Chris Graythen/Getty Images)

Its July, and that means a return to New Orleans Pelicans basketball! But its not the typical July basketball we are used to. Normally July means we are checking out the newest draft picks during summer league games in Las Vegas.

Who could forget our first look at Zion Williamson taking the court in a Pelicans uniform a year ago?

But this year is different in every way, including the NBA season.So what will the new version of the NBA look like in Orlando? Well find out soon enough.

All-Star Forward Brandon Ingram spoke to the media earlier this week about motivating each other and feeding off of each other during the games.

We have to use our own juice, our own energyjust like going back to open gym where were just trying to go at each other and trying to make the best out of each other, but trying to do it in the right way, Ingram told reporters. I think this is a time where we have to feed off of other people on the team and feed off the fire of the bench.

But the team doesnt just need to rely on each other when dealing with actual game play. The bubble format will also test their mental capabilities, as Jrue Holiday said in an interview with the AP.

This is one of the mental parts about it that guys have to adjust to, where someone like me, I go home and its where I kind of relax, Holiday said. I try my best not to bring my work home with me so I can hang out with my wife, my dog, and my daughter and I can do things like that. I think thats going to be a little bit of a challenge, especially after like seven to 10 days.

The Pelicans arrived in Orlando this week and will get rolling with their full-squad practices before three scrimmage games. The first game of the revamped season is July 30 against the Utah Jazz at 5:30 pm NOLA time, which you can see on TNT.

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Will the New Orleans Pelicans off-court chemistry matter more in closed campus? - Pelican Debrief

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UPDATE: People can return to homes and businesses following chemical spill – WQOW TV News 18

UPDATE 10:30 a.m. : Eau Claire police say people can return to their homes and businesses.

UPDATEEau Claire (WQOW) - According to the DNR, the truck that tipped was hauling 26,000 pounds of ammonium nitrate, 300 gallons of diesel and an unknown amount of dynamite.

Also per the DNR, local HAZMAT and airport HAZMAT are enroute and rougly 8,000 pounds of fertilizer has spilled. They also say a unknown amount of diesel spilled through a small hole in the tank.

Two storm drains are in the area and potentially impacted.

UPDATEEau Claire (WQOW) - Eau Claire police say a truck hauling hazardous material has tipped on Highway 53 near Interstate 94.

Eau Claire police tell News 18 the truck was hauling ammonium nitrate.

Because of that, police say they are evacuating all homes and businesses within 1/3 mile radius of the crash.

That includes residences in the Gatehouse Drive and House Road area and businesses in the Bullis Farm Road area.

Eau Claire (WQOW) - A stretch of HWY 53 is closed this morning due to an accident according to the Wisconsin Department of Transportation.

All lanes on HWY 53 on a stretch from Golf Road to the I-94 interchange are closed.

No word on how long the closure will be in place.

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UPDATE: People can return to homes and businesses following chemical spill - WQOW TV News 18

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The sponge with the secret recipe: A cancer-fighting chemical – Mongabay.com

Throughout the waters surrounding Indonesia, a porous tubular creature sits fixed onto coral reefs, its plain appearance hiding a potentially lifesaving secret.

Researchers recently found that this sponge produces a substance that could fight cancer and other lethal diseases, and theyve proposed cultivating it to benefit Indonesias marine environment and economy.

Acanthostrongylophora ingens yields a molecule called manzamine A, which counters cervical cancer cells in the lab, according to a paper published in the Journal of Natural Products.

Although Pap smears and human papillomavirus vaccines have lowered this type of cancers occurrence over the years, it remains the fourth most common in women, with roughly 14,000 diagnoses and more than 4,000 deaths projected in the U.S. alone for 2020 by the American Cancer Society. Manzamine A, which comes from bacteria living in a mutually beneficial relationship with the sponge, has huge implications for stopping this killer because it could restrain aggressive tumors without damaging healthy cells, according to the paper.

It prevents cell replication rather than killing the cell outright, leading to immediate impacts on tumor growth, and then other drugs are useful for killing remaining tumor cells, or they may die on their own, said Mark Hamann, a professor with the Medical University of South Carolinas Department of Drug Discovery and Biomedical Sciences and corresponding author on the study.

Success in humans remains to be seen, but it seems very hopeful. The agent would reduce toxic side effects, so thats the greatest utility.

Scientists at the Medical University of South Carolina, the University of South Carolina, the College of Charleston, Gadjah Mada University in Indonesia and the University of Malaya in Malaysia analyzed how manzamine A inhibited the growth of cervical, prostate and other cancer cells. They observed that it checked the proliferation of cervical cancer cells but didnt affect non-cancerous ones. Models revealed that while it looks like other inhibitors of cancer, manzamine A has 10 times the effect on a harmful protein associated with it.

If it ends up advancing in the control of cervical cancer, Im certain that it finds applications in other forms of cancer, Hamann said, particularly those characterized by that protein. If produced on a large scale, its a good candidate for modifying and may find utility broadly in infectious diseases.

Now the scientists are further testing and developing the compound which has been shown to cure malaria as well and determining safety, dosage and administration methods. They plan to conduct clinical trials later on patients who havent had any luck with other types of chemotherapy.

Since manzamine A is difficult to create artificially, and sponge aquaculture has proven profitable with bath sponges, Hamann said he recommends growing A. ingens commercially in Indonesian seas to not only obtain the drug but to also improve ecological and economic conditions.

This very desirable fisheries project, he said, would involve hanging sponge cuttings from ropes underwater. The filter feeder, which thrives where water is fairly poor quality and many other species do not survive, could purify contaminated water, buffer unspoiled reefs from pollution, and otherwise enhance the marine ecosystem. And establishing an industry centered on the sponge would supply extra income to Indonesians, help boost their standard of living, and contribute to the countrys economy.

Since the sponge produces this molecule in high yields, and it seems easy to grow, you could grow it in polluted waters near wastewater plants or river mouths along the ocean, and it would potentially grow very well, Hamann said. It would be a promising economic development tool to put sponge culture facilities where theres high nutrient loads to improve water quality and build a business around the manufacture of the drug. Itd have a valuable local impact.

Netty Siahaya, a lecturer at Pattimura Universitys School of Mathematics and Natural Sciences and sponge chemicals researcher who wasnt part of this study, emphasized the vast possibilities of substances like manzamine A, which enable sponges themselves to deal with threats such as viruses.

But she said that to get the potential of the sponge as a cancer drug, we can take it at locations estimated to be clean compared to locations with very high activities that are likely polluted. Heavy metals and other contaminants could bind to manzamine A, she said, making it more difficult and expensive to extract.

Like many coastal organisms in Indonesia, sponges have generally declined in recent decades due to habitat-degrading human impacts such as coral extraction and pollution, said Victor Nikijuluw, senior director of Conservation International Indonesias marine program.

Culturing sponges for pharmaceuticals and using sponges to gauge ecosystem health would provide greater impetus for the protection of coral reefs as well as the animals themselves, which perform additional services such as carbon regulation, Siahaya said.

To maintain the existence of sponges, we need to cultivate them and protect aquatic ecosystems, she said.

Nikijuluw agreed that farming A. ingens is a nice idea, especially considering that Indigenous peoples on Indonesias eastern islands have long harvested shallow-water sponges for medicinal and other household purposes. He pointed out the gaping lack of information about Indonesian sponges and their useful properties and stressed tapping into traditional knowledge to learn about them.

Marine conservation planning in Indonesia, he said, should no longer disregard sponges.

Were relying on the biodiversity of corals to decide if a particular site should be conserved, Nikijuluw said. Where you will find a lot of sponge, no corals, if you just focus on coral, you will not conserve The sponge should be included in the reasoning for conservation.

Even if A. ingens turns out to be unfeasible for cancer treatment, it should still be conserved, Nikijuluw suggested, perhaps partly through cultivation for another identified use.

Regardless, he said, if we do not know the benefit of the species to human beings, we cannot conclude that this species doesnt have any function. Right now, science may not disclose those functions, but later, youll understand If it is has no direct benefit to human beings, it has an indirect benefit through the environment.

Citation:

Karan, D., Dubey, S., Pirisi, L., Nagel, A., Pina, I., Choo, Y., & Hamann, M. T. (2020). The marine natural product manzamine A inhibits cervical cancer by targeting the SIX1 protein. Journal of Natural Products, 83(2), 286-295. doi:10.1021/acs.jnatprod.9b00577

Banner: The cancer-fighting marine sponge, A. ingens, is prevalent throughout Indonesia, including in Manado Bay. Image by Sakurai Midori.

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The Relationship is Over. The Chemistry is Gone: Former Teammate Urges Sebastian Vettel to De-Maranello His Mind – Essentially Sports

For Sebastian Vettel, the season opener didnt quite go the way he would have hoped for. In fact, far from it, it was a debacle. The 4-times world champion had a poor qualifying and started the race in P11.

However, if he was hoping for a much-improved performance in the race, that hope was sent flying out of the window, after he spun trying to get past Carlos Sainz on the inside.

All in all, it was a very tough day in the office for the German. He only managed a solitary point, finishing P10, thanks to several drivers retiring ahead of him.

Mark Webber, Vettels former teammate at Red Bull, took pity on him and has suggested that the relationship between Vettel and Ferrari is no more.

The former Red Bull driver Mark Webber appeared on the podcast, In The Fast Lane, and said, The relationship is over. The chemistry is gone, the marriage is over.

Sebastian is dressed in red, hes driving a red car but hes there for himself. In some scenarios, you wish it could be over now because thats pretty much how its looking.

Webber also feels that the way Vettel was told about his future with Ferrari, was an indication that the relationship between him and the team was already cold.

He said, I think it surprised most of us. Sebastian probably the most, of news that there was no contract offer. Clearly, that relationship, or the dynamic of how that was going, wasnt healthy and they thought it was best not to continue.

However, Webber doesnt think that the Germans F1 days are done as of yet. He said, I dont think its over yet. I think he still has a chance to get something in 22. Who knows, maybe 21 at Red Bull?

I think he needs to reinvent himself and de-Maranello his mind, in terms of trying to get that energy back. I think hes still going to be on the grid in the future, whether its 22 or 21. Hes still got a bit left in him.

Nevertheless, at the moment, Vettel will not be thinking too much about what the future has in store for him. Instead, hell be looking forward to the next Grand Prix, in the hope of some redemption.

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Any mask helps: Local chemistry professor tests how effective masks are against the spread of COVID-19 – WJHL-TV News Channel 11

ELIZABETHTON, Tenn. (WJHL) One chemistry professor saw different kinds of experiments surface on social media and decided to examine how effective different kinds of masks are against the spread of the novel coronavirus.

Milligan University Assistant Professor of Chemistry Kristen Mudrack told News Channel 11s Bianca Marais that she had seen plenty of studies and experiments on mask effectiveness, but she and her research assistant Madison Blanton, wanted to focus more on the different types of masks.

I did the experiment, I said all the tongue twisters, with a hospital mask, a cloth mask that I had made and an N95, which was not fitted to my face so there were some spaces that the air could get out and what my research assistant and I found was that any mask helps, Mudrack explained.

With no mask, theres a whole bunch of droplets on the plate, with a cloth mask or a hospital mask or an N95, theres maybe one or two droplets on the plate. Now, the thing to understand about this, is that those are bacterial droplets, we do know that COVID spreads through aerosol droplets, okay, so when you talk, even though you dont realize it, you are spraying things out of your mouth and nose. The virus travels through those particles. Whats on those plates is bacterial growth, not viral growth, but the priciple still stands. Viruses are going to travel further because theyre smaller but any aerosolized particle is going to get stopped by a mask, and thats essentially what I found: that any mask helps more than no mask, she explained.

This is how Mudrack said the experiment was conducted:

I held it in front of my face, about a foot and a half, said a bunch of tongue twisters, covered the plate and then set it in the incubator for about a week. The reason I let it go for a week instead of just a day, was to magnify the growth on the plates. After a day, I checked them and you couldnt see a whole lot, you could tell that there was something, but I knew that it would be better to see after about a week what was actually there, she said.

Mudrack also included a control Petri dish.

So that I knew that if something grew on that plate, there was something in the air that was settling onto the plate, she said. What actually happened, was on the control plate, nothing grew, which tells me that its not something thats in the air thats getting it here to the plate, its when Im actually talking, the aerosolized droplets are landing on the plate and growing.

Mudrack told News Channel 11s Bianca Marais that she was most surprised by the N95 mask.

The N95 has a really big spot on the plate and that is likely because the mask was not fitted to my face. The other reason N95s arent as good as we initially thought is because some of them have that valve. That valve only filters what goes in, but not what comes out and so youre still actually breathing out aerosolized particles, that would end up on a Petri dish like that, she explained.

She explained that scientists, over the last six months, have proven that COVID-19 spreads through droplets that have to somehow be projected. This happens when we talk or cough or sneeze, Mudrack explained.

What were trying to accomplish with social distancing is staying far enough apart, that those droplets kind of dissipate before they get to the person, thats also what a mask does, she explained. So, the mask is going to stop the droplets before they ever get into the air.

To her, someone who is immuno-compromised, the issue is personal. She asks that people wear a mask to help limit the spread of the coronavirus.

The science is there. It has been proven over and over how COVID is spread and youre seeing science move at such a fast pace right now, that weve never seen before and probably never will see again in our lifetime. Yes, we keep getting emerging information, thats how science works, and if it turns out that masks really dont help, whats the harm in wearing one? Even if they dont help, its just a small thing that doesnt hurt. Now, the science is there that it does help and it does reduce the spread of COVID, and thats why we are being asked to wear them in public, she said.

Continuing coverageof the COVID-19 coronavirus pandemic.

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Any mask helps: Local chemistry professor tests how effective masks are against the spread of COVID-19 - WJHL-TV News Channel 11

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