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Catch and Release: MTU Biochemists Purify Proteins with a Fishing Technique – Newswise


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Newswise Biochemists developed a catch and release technique to find the specific protein theyre fishing for.

The technique is explained in a new paper published in the Journal of Biological Chemistry. A team of biochemists from Michigan Technological University, including students, did the research, which is led by Tarun Dam, associate professor of chemistry.

Protein purification is a multibillion-dollar industry, Dam said, explaining that proteins are important for studying everything from cancer to allergies to vaccines. Unless you purify a protein, you dont know what it can do. We set out to improve that process.

Go FishFor Proteins

Much like fishing, Dam and his teams technique comes down to selecting the right lure and knowing the habits and habitat of what theyre baiting. They call their system CaRe, short for capture and release, and it follows four steps.

First, the team has to capture the protein theyre looking for. They do this by picking the lure: The tackle box is full of ligands, which are molecules with pincer-like arms that can bind proteins between the prongs. Much like fish that prefer different flies, lures or live bait, different proteins bind better with different ligands.

The hook needs to be a specific capturing agent, Dam explained, adding that the second step is to isolate the bound protein. Now we need the centrifuge. Once the protein is caught, the molecules weight becomes heavier, so they come down in solution.

The third step is to remove the isolated ligand-protein complex much like getting the fish into the boat and the fourth step is to get the hook out and separate the ligand and protein. Once separated, the protein stands alone, a purified end product.

No technique is 100% perfect, Dam said, noting that isolating low levels of a protein is akin to trawling for walleye where the sunfish hang out. Also, just like real lures, some proteins are picky and some ligands attract everything; a challenge and delight that keeps many people in waders and lab coats.

What we are most excited about is the simplicity of the technique, Dam said.

CaRe can isolate and separate out proteins in a day or two compared to the greater expense in both time and cost of current protein purification systems.

Glycoproteins, Cancer and Immunotherapy

Dam and his Michigan Tech collaborators, notably research assistant professor Purnima Bandyopadhyay, were able to develop CaRe because of the nature of the proteins. Alongside carbohydrates and fats (lipids), proteins are an important building block of living organisms.

About 60% of proteins are glycoproteins, meaning they have a sugar-based chain attached to them, and for decades, researchers thought the chains were junk structures. But as often happens in research over time, the sugary chains proved to be a key part of how proteins interact with their environment and the cells around them.

In his primary research, Dam explores a specific proteins interactions. Galectin-3, or simply Gal-3, is an important biomarker for thyroid cancer and a multitasking protein. Bandyopadhyay makes recombinant Gal-3 and its mutants in the lab. As Dam developed his Gal-3 research and needed to screen different proteins, he was set back by the cost and cumbersome processes of protein purification. So, he asked Bandyopadhyay, can we go fishing?

In addition to his own work, Dam is excited to see other labs apply the CaRe technique. It simply requires basic equipment and the chemistry equivalent of old fishing wisdom to know what lure catches what. Whether its sorting out cancer-related glycoproteins and proteins like Gal-3 or purifying proteins for immunotherapy treatments, luring the right molecules becomes as simple as catch and release fishing.


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Biochemistry Analyzers Market 2027: Topmost manufacturers With Size, Regions, Types, Major Drivers, Profits Dagoretti News – Dagoretti News

Latest release from SMI with title Biochemistry Analyzers Market Research Report 2019-2026 (by Product Type, End-User / Application and Regions / Countries) provides an in-depth assessment of the Biochemistry Analyzers including key market trends, upcoming technologies, industry drivers, challenges, regulatory policies, key players company profiles and strategies. Global Biochemistry Analyzers Market study with 100+ market data Tables, Pie Chat, Graphs & Figures is now released BY SMI. The report presents a complete assessment of the Market covering future trends, current growth factors, attentive opinions, facts, and industry-validated market data forecast until 2026.

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Should Marriage Therapists Give Couples MDMA? – The Atlantic

Read: How negativity can kill a relationship

Irrational anxieties and emotional repression can of course cause relationship problems, so its feasible that a few hours of reduced inhibitions and fears, paired with some gentle guidance from a therapist, might help some couples. The two psychiatrists found that some 90 percent of their clients benefited, and many of them reported that they felt more love toward their partners and were better able to move beyond past pain and pointless grudges.

Earp and Savulescu are careful to point outat several points throughout their bookthat drugs like these have shown promise in some settings, but require much more research before they should ever be considered viable mainstream treatment options. And if they ever reach that status, Such drugs should never be taken in a vacuum, alone or with unprepared others, without the right mental or emotional groundwork, or with the expectation that they will induce improvements all on their own, the authors write. They wont.

Dominic Sisti, who teaches medical ethics and health policy at the University of Pennsylvania, notes a widely shared view among bioethicists: Certain drugs and pharmaceuticals can and should be used in therapy contexts. MDMA especially can help reform the bonds that maybe were under stress, or broken through years of challenges or difficulties in a relationship. Or it can provide insight that maybe the relationship is over, he told me. Those are things that often take weeks, months, years of therapy to get to, but MDMA sort of catalyzes that.

Sisti also agreed with Savulescu and Earps identification of gray marriages with kids as having the most to gain from chemical intervention. Still, he said that some in the bioethics field object to the love drugs ideamainly due to religious or quasi-religious beliefs about love and marriage. The most common argument [against it] is that youre sullying something thats divine, he said, that its a spark given by God, or preternatural in some way that we shouldnt be screwing around with.

Earp and Savulescu acknowledge the criticism, but they ask readers to consider romantic love the same way they might consider another one of lifes (smaller) pleasures: cake. Imagine the way it feels to eat the first bite of a delicious baked good, they writeand then, imagine that you helped bake it. Does the cake taste any less delicious to you now? Does knowing the recipe, the chemical makeup of the various ingredients, somehow rob your tongue of the flavor it so craves?

Indeed, the authors suggest that familiarity with somethings inner workingshow all the ingredients affect one another, how adjusting their ratios might help or hurt the end productnot only wont spoil the magic, but might enhance it. And in the case of a relationship that has produced a family, that knowledge might just save it.

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The Future of Food – UC Davis

Food is more than the energy that fuels our bodies it is preventive medicine. Maybe not a cheesy chimichanga, but the type of food that is loaded with vitamins and proteins can maximize the benefits to the human body.

We need to look at the functional properties of food more closely so we can achieve the desired outcome, said Justin Siegel, associate professor of chemistry, biochemistry and molecular medicine, and faculty director for the Innovation Institute for Food and Health. Instead of focusing on the quantity of food which is a legitimate long-term concern globally lets hone in on creating quality food that possesses more active nutritional ingredients that deliver greater health benefits with every serving.

Siegel has a vision to transform the greater Sacramento region into the incubator pipeline for food science innovations. The initiative, dubbed Food Valley, would accelerate the commercialization of game-changing ideas across the food system by tapping into research, industry and policy. It would also prepare tomorrows food innovators and entrepreneurs through experiential learning programs.

Food Valley aims to patent its food innovations through developing technologies. These concepts can be grown into companies and potentially be a launchpad for Aggie entrepreneurs.

Siegel became interested in biotechnology as a kid. More recently, he thought about the possibilities of using biotech to disrupt the food systems industry. He co-founded PVP Biologics, a food biotech company, in 2016. PVP created a pill called KumaMax, which could help those who have celiac disease. KumaMax is currently in clinical trials, awaiting FDA approval.

Food Valley is about letting people experience freedom in what they are able to eat especially as it pertains to food allergies and restrictions, Siegel said. With modern technology we can both see the exact molecules that make up our food and manipulate those molecules to change how they interact with someones body.

No centralized hub for food innovations exists yet. Siegel said he believes UCDavis has the right ingredients to emerge as the leader.

Twenty years ago, this was science fiction, he said. Now we can do things we never thought possible. There is going to be a hub for food innovation, and UCDavis should be the place it happens.

This is one of several Big Ideas, forward-thinking, interdisciplinary programs and projects that will build upon the strengths of UCDavis to positively impact the world for generations to come. Learn more at

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Med Students Get Real: Everything Premeds Need to Know – Thrive Global

The premed life is notoriously hard. Anecdotal tales about the difficulty of weed out classes like organic chemistry inextricably intertwine with research reports about significantly higher prevalence and severity of emotional exhaustion and depression in premed students compared to their non-premed counterparts.

I can discern this culture of intense pressure, severe burnout, and extreme fatigue as a premed student myself. Having said that, I have noticed that there is one very powerful force when it comes to fostering a wellness-based culture among premed students: mentorship from premed upperclassmen or current medical students.

Research illustrates the helpfulness of near-peer mentoring in medical schools, indicating improvements in communication skills, profession development, and even personal development for both mentees and mentors. One Swedish study found 81% of medical students in a 2-year mentorship program felt they received emotional support from their mentors, 91% felt they received perspective from their mentors, and 87% felt they received guidance.

Mentorship programs clearly help. Unfortunately, though, premed programs at undergraduate institution do not place the same emphasis on formal mentorship programs as medical schools. Thats why I asked a bunch of med students to tell me everything premeds ought to know.

One thing I highly recommend premeds to do in undergrad is to pursue interests outside of science and medicine, whether that be through extracurricular experiences or classes. The medical school curriculum is already chock full of a lot of biology/biochemistry/physics-heavy topics, which makes undergrad a great time to explore topics that are not explicitly covered during those four years. Its a great opportunity to learn more about the world and yourself, as well as develop into a more well-rounded individual who can capably function and interact both inside and outside of a medical context. Ultimately, we are all entering this profession for the betterment of humanity and being able to develop and preserve our own humanity is just as important.

-Julian Mak, MS1 Albany Medical College

The biggest difference between medical school and college is mainly the volume of work, not necessarily the difficulty of material. I found that I was much more successful once I figured out the best way to digest the material in chunks rather than getting overwhelmed by how much there was. Its helpful to set both daily and weekly goals for what you want to get done and also scheduling into your day normal life things like laundry, groceries, and cooking.

-Allie Mignucci, MS1 Albany Medical College

Everyone digests information differently so figure out what works best for you in terms of learning new material whether its listening to a lecture, reading a textbook, making an outline, or a little bit of everything. Medical school is fast paced so making sure you know how to study effectively and efficiently is key.

-Talitha Kumaresan, MS1 Albany Medical College

It doesnt necessarily have to be medically related but make sure you learn the basics of conducting scientific research (question, hypothesis, study design, analysis, presentation, etc.

-Talitha Kumaresan, MS1 Albany Medical College

I would also encourage students to take the time to learn more about different populations, whether they vary socioeconomically, culturally, racially, etc. Understanding the history of how disparities among different groups of people have developed over time into the present day can shed a great understanding about how we as future medical professionals can most effectively understand, empathize, and interface with patients of all different belief and value systems. At times, it can feel like medical school is a sort of bubble where we are shielded from what is going on in the world around us. However, it is important to always remember that the patient should be a medical professionals highest priority, and spending some time to learn more about these individuals and look at them as people with a story can go a long way in enriching the way in which we care for them.

-Julian Mak, MS1 Albany Medical College

The main thing I wish I knew as premed student working tirelessly to get into medical school is that your wellness, maturity, and individuality is equally as important as all of the accolades you can stack through academia. I realized going through medical school that all of my classmates are vastly different people with various experiences and that the key to us being such a cohesive class was our desire for work-life balance. Dont ever forget to be a person and enjoy time with friends and family. If it was between that extra hour studying for an exam that you have spent already too much time on versus catching up with friends over dinner or drinks, realize that the latter will keep you sane and personable. As for maturity and individuality, just realize that the student body that makes up any medical school is not often the 22-year-old superstar that was 4.0 and top of their class. Many of the students, including myself, are individuals who took time off to gain experience in life on top of strengthening our applications. I worked at Starbucks for half a year and I can tell you that I have talked to more physicians during my residency interviews about my time there compared to all of my research and medical experience combined. Not everyone needs to work a service job, but there a lessons learned in the workforce that are invaluable for every type of a job including that of a physician. Not everyone has the same track to get to medical school, but if you want it bad enough and are willing to be honest with yourself, no matter how many years you may need, you can get there.

-Mario Jaramillo, MS4 Albany Medical College

Med school can be confusing, so make sure you have some healthy self care habits. I try to take an hour a day for myself whether I exercise, read, cook or watch tv. Developing those habits and taking care of your mental health will keep you sane and happy in med school.

-Talitha Kumaresan, MS1 Albany Medical College

Take time to relax and have fun however way you do that with the time you have during undergrad. The workload in medical school definitely ramps up with the combination of classes, dissections, research, and other commitments. Burnout is already a huge problem in the medical profession, and that issue doesnt need to trickle down even further if we can manage it. Sometimes it may be tempting to look towards the next step (as I did with medical school in my senior year), but remember that the process of training to become a physician is a many years-long marathon, and the last thing you want to do in a marathon is to expend all your energy in the first portion of the race. Preserve and maintain your physical and mental health.

-Julian Mak, MS1 Albany Medical College

Dont be so focused on medical school that you forget to enjoy college and all the experiences you can have. Get involved as much as you can, make friends, enjoy your free time.

-Talitha Kumaresan, MS1 Albany Medical College

Youre a premed. Dont worry, thats not all you have to be. This is a tough field and its a tough journey to get into medical school. But that doesnt mean life needs to be on hold while you reach that next milestone in your career. While you make your way there, life will keep happening. Dont ask it to stop for you. Soon youll be in medical school and youll continue to make yourself empty promises of getting back to life before and after each of the many challenges that you will face throughout your career. So be premed, but dont let that stop you from being an artist, musician, dancer, or movie buff. Dont let it stop you from being a daughter, sister, or friend. Dont let it stop you from living life. Medicine is a part of your lifedont isolate it from the rest of what makes you you.

-Vinita Kusupati, MS4 Albany Medical College

In the difficulty of premed courses, its easy to question if this path is worth it or if the countless hours of studying organic chemistry will even matter when you actually take care of your patients. But in those moments, remind yourself of the future patients you are doing this for because they will give you the strength to persevere and keep going.

-Brian Lee, MS1 Albany Medical College

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The Guardian is the latest old-line publisher to reach outside the business for a CEO – Digiday

Publishers are increasingly looking outside of their own immediate publishing spheres for new chief executive hires, in the hopes of bringing in fresh thinking from a related industry.

This week the Guardian announced that neuroscientist and former academic publisher Annette Thomas would be its new CEO. In September U.K. newspaper group Reach appointed as its new chiefJim Mullen, the former boss of gambling firm Ladbrokes Coral.And in AprilRoger Lynch joined Cond Nast from Pandora, the music streaming service provider. And at the start of last year, USA Todays owner Gannett had instructed its headhunting firm to search beyond the newspaper industry for CEO candidates.

The rationale behind for each publishers deliberations is unique, of course, but the changing (and challenging) nature of the publishing industry is a significant factor. Many of the skills required of a modern publishing executive building consumer revenue, managing the sophisticated use of data and driving workplace cultural change are not readily found among the tried-and-true candidates found within internal ranks or at competitors.

Thomas is a case in point. Many media observers seized on her scientific qualifications her Harvard undergraduate degree in biochemistry and biophysics (achieved with honors) and Yale doctorate in cell biology and neuroscience. But her background in academic publishing might be her most important credential.

In 2007, Thomas became chief executive of Macmillan Publishers, a leading science and education publishing group; she oversaw Macmillans merger with Springer Science and Business Media. And after she spent 23 years helming Macmillan, she became CEO of higher education data business Web of Science Group. Thomas has been lauded for her overall strong leadership skills, after leading both Macmillan and Web of Science through mergers and in the latter case, even a public listing. As one former colleague of Thomas said, shes terrific and [Guardian Media Group needs] a new leadership style.

The Guardians critical membership business will rely on Thomas experience with growing the number of subscriptions and managing churn, observers said.

Thomas will bring fresh thinking, but still, how do you persuade consumers to donate in order to drive meaningful subscription revenue? asked independent media analyst Alex DeGroote. The Guardian is at an inflection point. Its had years of fairly fierce cost cutting; breaking even is not the same is growing. What strategy will she bring to the table?

The appointment of Thomas represents a shift in the leadership at Guardian. She succeeds David Pemsel, who ascended to the CEO post in 2015 after working for the Guardian five years and also performing other media roles, including working at a broadcaster (ITV), a production shop (Shine) and an advertising agency (Ogilvy). Pemsel was responsible for steering the Guardian out of the red and into slim profitabilitythrough heavy cost cutting after two decades of financial losses.During Pemsels CEO tenure, the publisher diversified its revenue model so as to rely more on reader-derived revenue than advertising. Industry onlookers had pegged for the top job strong internal candidates like chief customer officer Anna Bateson,who leads the Guardians membership strategy.

An exclusive, inside look at whats actually happening in the video industry, including original reporting, analysis of important stories and interviews with interesting executives and other newsmakers.

Annette Thomas is a strong appointment because of her substantial experience in global publishing, in all things digital, and in M&A, deals and fundraising, said independent media consultant Colin Morrison. Those strengths point toward what I believe is the Guardians future in using partnerships, joint ventures and strategic alliances to become a truly global and 100% digital news media group.

While Jim Mullens CEO appointment at Reach raised some eyebrows, media observers say the former gambling firm boss has brought his knowledge of how to run a digitally sophisticated, consumer-facing marketing business with an understanding of how people behave. Indeed he is not a newcomer to publishing: From 2006 to 2010, Mullen worked at News UK as director of digital strategy.

And with Roger Lynchs arrival last year at Cond Nast after serving as CEO of Pandora as well as an executive for streaming service provider Sling TV, he brought something quite different than conventional magazine publishing experience: expertise in managing large complex organizations, as well as key growth areas like subscriptions and over-the-top video.

Nonetheless, even though Gannett instructed its headhunting firm to consider CEO candidates with digital or e-commerce backgrounds outside the newspaper industry as possible change agents for USA Today, in AugustGannett ended up appointing Paul Bascobert, a former president of media and technology company XO Group.

But in the Guardians case, the hiring of an executive who has worked outside the consumer publishing business represents a careful balancing act a move to grow the organization in new directions all without losing sight of its core values, according to Douglas McCabe, CEO at Enders Analysis. The CEO of the Guardian needs to be someone who is highly sensitive to the culture of the organization, which has a more complex agenda than most commercial news businesses, but without drowning in it, McCabe said. Annettes experience looks a perfect fit, balancing experience managing the complex culture of a comparable set of industry challenges with commercial nous, data analytics and expertise in planning for long-term, structural, industry change.

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