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Precision Medicine, Nanotechnology and the Rise of the Robot Now. Powered by – Now. Powered by Northrop Grumman.

Since then-President Obamas announcement in early 2015, precision medicine has been an even bigger buzzword in medical research. Its one of those terms you hear frequently, but what exactly is it? And what makes it so important for future health care?

Its both, but definitely not average. The term replaces the older description, personalized medicine. Although they mean roughly the same thing, precision medicine is the preferred term for developing treatment and preventive medicine for individuals based on genetic, environmental and lifestyle factors. In translation: instead of a one-size-fits-all approach for an average patient, the precision approach looks at individual variability when mapping out the treatment plan that has the best chance of success. Doctors base the drug choices on the individual patients genetics.

So, apart from maximizing success, what makes precision medicine so important?

Consider cancer, one of the short-term goals outlined in Mr. Obamas 2015 initiative. Characterizing a patients cancer helps clinicians design an effective treatment plan. Tissue profiling reveals cell markers that are useful when choosing chemotherapeutic drugs. For example, breast cancers that overexpress the HER2 receptor respond very well to trastuzumab (Herceptin) treatment, whereas those with abundant estrogen receptors respond better to hormone therapy. This kind of approach can also customize treatment for other conditions.

How do doctors know what works?

Omics is shorthand for a suite of biotechnologies devoted to uncovering the secrets of the genome (DNA), the proteome (proteins), the transcriptome (how genes translate into proteins) and more. Essentially, omics researchers study the basic machinery of the cell and how growth, aging, disease and nutrition affect it. These technologies underpin most research into precision medicine. By studying thousands of individuals, researchers build a picture of health, disease and risk.

Cataloging the genomic information from thousands of individuals in large population cohorts, and then matching it up with health, environmental and lifestyle records shows genes associated with specific diseases. In tumors, it shows how sensitive they are to chemotherapy.

Omics technology is advancing very rapidly and generating vast amounts of data. Sequencing a persons genome first took almost 10 years and $3 billion; current next generation sequencing (NGS) instruments will whiz through around 18,000 individuals or more in a year. Proteomics technology is catching up rapidly.

One genome generates around 780 MB of data out of around 30 terabytes of raw NGS data; typical proteome datasets run into many gigabytes in size. Studying thousands of individuals for population studies generates terabytes of data approximately 40, according to one article. And that takes a lot of processing power to analyze for clinically relevant results more than can be done manually, so biomathematicians develop algorithms and other software tools to tease the answers from the digital soup. Bioinformatics for storing and accessing electronic health records is vital for precision medicine research. Furthermore, IT systems such as the Northrop Grumman-supported MedDRA initiative encode health information consistently ensure that data banks can talk to each other, with advances in cybersecurity ensuring patient privacy despite the cross talk.

Yes. Just think of where all that data comes from.

Population studies are as big as they sound; the Million Veteran Program collects biosamples from U.S. veterans, around 400,000 so far. It aims to generate omics data that in conjunction with information on health, lifestyle and environment will translate into clinical practice. Thats a lot of samples to handle, store and analyze.

Furthermore, microelectronics advances mean that omics instruments handle more samples at a faster rate. Next-generation sequencers such as the Illumina HiSeq and the Thermo Fisher Ion Torrent use chip-based and semiconductor technology to decode genomic materials. A simple flash of fluorescence or change in pH zaps DNA base pair information into a digital format much faster than old-school gel-based Sanger sequencing.

In order to exploit the speed of these tools, robotic handling manages everything from sample aliquots for biobank storage, to 384-well plate assay wrangling. Their speed and automation bring faster results with fewer errors.

Robotic or automated workflows are also important for nanotechnology and microfluidics where the miniaturization that reduces instrument footprint and sample volume also precludes manual input. Even though they will benefit from precision medicine, our clumsy fingers and thumbs are not as welcome in the lab as they once were.

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Applications of nanotechnology in the automotive industry – Geospatial World

Nanotechnology the creation and use of devices and machines on almost an atomic level is likely to be the driving force behind the next great revolution to benefit humankind. The actual definition of nanotechnology can be quite broad, generally, in scientific and engineering terms, nanotechnology is the manipulation of matter with at least one dimension sized from 1 to 100 nanometers (0.000000001 m). That really does put it on an atomic scale, though the products that can be constructed in this way may be a little larger and can range from microscopic to anything under a millimetre.

While this kind of technology will have applications in many fields, there are likely to be huge advantages in the field of cars and motoring and in the near future, nanotechnology is likely to have a massive impact on the world of driving and vehicles.

It is a fact that nanotechnology can impact so many areas of motoring makes it one of the most important up and coming technologies, and it has attracted the attention of a great number of researchers. This has led to a growing number of breakthroughs in the field, and even more possibilities for this exciting and highly flexible area of science to push different fields of motoring forward. But where is nanotechnology having the greatest influence in car manufacture?

We ask a lot of our internal combustion engines in terms of both increased performance and decreased size and weight. Those two elements together would usually mean disaster for a high-performance engine, but nano-engineering has allowed us to do both, and safely. Engine blocks, which house the fundamental moving parts of the mechanism, were traditionally made of cast iron, because it was the only practical material that could resist the high temperatures and pressures that were produced in the heart of an engine. But engineers soon found that certain grades of aluminium which weighs around a third that of cast iron were found to be suitable too.

But now, engineers have learned how to manipulate aluminiums on an atomic level nanoengineering to create materials that are both stronger while being more lightweight than even the current batch of strong aluminium alloys. This makes them even more fuel efficient while having an increased durability, even in the increasingly hostile conditions found in modern engines. It is a fact that an internal combustion engine performs better and is more efficient at higher temperatures, so this is always a goal for engine designers. We are now also experiencing methods of placing ultra-thin layers of engineering ceramics on metal substrates, creating a surface that is capable of withstanding higher temperatures and wear situations.

Manipulation of either the fundamental structure of the engine block material, or the surface architecture or both, even gives designers far greater scope in heat dissertation, wear characteristics, and strength at elevated temperatures.

We have also seen advances in motor oils, particularly in respect to their ability to withstand the punishing environments of modern engines. Nano-manipulation has created a new breed of oils that are able to cling to internal surfaces for longer, meaning that it is in the right place when the engine starts, so that it offers protection right from the start. Nanotechnology oils are also able to put up with much greater use as the tolerances between engine parts decreases and they operate closer together.

Fuel efficiency, whether the car is petrol, diesel, or electric, is a function of its weight, and even quite small reductions in weight can lead to increase attained mileage significantly. One of the best ways to cut the weight of a vehicle is to use lightweight materials for the structural chassis parts and the exterior, and this is another area where nano-manipulation of materials can create stronger, more lightweight, panels and chassis that are stronger than the ones that they have replaced. Nanotechnology is also responsible for the creation of plastic panels that are able to self-repair and reform themselves following damage.

As the next generation of electric vehicles become common on our streets, engineers and researchers are looking at how to lengthen battery life while increasing performance. This has led to the development of lithium-silicon batteries which promise to boost performance and increase longevity. The latest developments in this fast-moving include silicon nanowires that expand and contract as they absorb and shed lithium ions, and tiny nano-structures with carbon shells protecting lithium-rich silicon cores. This combination allows for more efficient energy transfer, meaning that less energy is lost to the environment as heat and more is supplied to the system.

Nanotechnology is also improving fuel cells the clean alternative technology to hydrocarbon fuels. In these, hydrogen is passed over a catalyst to produce hydrogen ions which then go on to reattached to oxygen and result in energy production. The catalysts are increasingly variations of platinum nano-structures to maximise the surface area and harvest the greatest number of hydrogen ions, thereby maximising energy production too.

Nano-sized layers of inorganic filters are increasingly being applied to the vulnerable surfaces of car bodies, to help protect them from harsh environments, and self-repair to an increasing extent. The smart particles can also help repel dirt and grime, keeping your car looking cleaner, while new developments in orientable surface particles mean that we may soon be able to change the outer colour of our cars by adjusting small electrical charges to them.

Interiors. The use of specialist nanotechnology fabrics is helping to keep the interiors of our cars looking fresh and clean, but also repellent to bacterial affects, creating soft, good looking and completely safe interiors. Once again, developments are being made that will allow the colour of the interior to be changes by reorienting the nano-particles of the material, so that the user can choose any combination of colour that they like, while still having excellent antibacterial properties.

Nanotechnology in cars is becoming big business, and as we find new ways to manipulate materials on an atomic scale, so new applications arise. This will lead to cleaner, quieter, more pleasant cars in the future, and that can only be a good thing.

Note: This is a guest blog by Giles Kirkland, an automotive industry writer and researcher.

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Applications of nanotechnology in the automotive industry - Geospatial World

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Nanotechnology Market 2020 | Growing Rapidly with Significant CAGR, Leading Players, Innovative Trends and Expected Revenue by 2026 – Skyline Gazette

New Jersey, United States:The Nanotechnology Market is carefully researched in the report while largely concentrating on top players and their business tactics, geographical expansion, market segments, competitive landscape, manufacturing, and pricing and cost structures. Each section of the research study is specially prepared to explore key aspects of the Nanotechnology market. For instance, the market dynamics section digs deep into the drivers, restraints, trends, and opportunities of the Nanotechnology Market. With qualitative and quantitative analysis, we help you with thorough and comprehensive research on the Nanotechnology market. We have also focused on SWOT, PESTLE, and Porters Five Forces analyses of the Nanotechnology market.

Global Nanotechnology Market was valued at USD 1.03 Billion in 2018 and is projected to reachUSD 2.29 Billion by 2026, growing at a CAGR of10.40 % from 2019 to 2026.

Leading players of the Nanotechnology market are analyzed taking into account their market share, recent developments, new product launches, partnerships, mergers or acquisitions, and markets served. We also provide an exhaustive analysis of their product portfolios to explore the products and applications they concentrate on when operating in the Nanotechnology market. Furthermore, the report offers two separate market forecasts one for the production side and another for the consumption side of the Nanotechnology market. It also provides useful recommendations for new as well as established players of the Nanotechnology market.

Nanotechnology Market by Regional Segments:

The chapter on regional segmentation describes the regional aspects of the Nanotechnology market. This chapter explains the regulatory framework that is expected to affect the entire market. It illuminates the political scenario of the market and anticipates its impact on the market for Nanotechnology.

Analysts who have authored the report have segmented the market for Nanotechnology by product, application and region. All segments are the subject of extensive research, with a focus on CAGR, market size, growth potential, market share and other important factors. The segment study provided in the report will help players focus on the lucrative areas of the Nanotechnology market. The regional analysis will help the actors to strengthen their position in the most important regional markets. It shows unused growth opportunities in regional markets and how they can be used in the forecast period.

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Highlights of TOC:

Overview: In addition to an overview of the Nanotechnology market, this section provides an overview of the report to give an idea of the type and content of the study.

Market dynamics: Here the authors of the report discussed in detail the main drivers, restrictions, challenges, trends and opportunities in the market for Nanotechnology.

Product Segments: This part of the report shows the growth of the market for various types of products sold by the largest companies.

Application segments: The analysts who have authored the report have thoroughly evaluated the market potential of the key applications and identified the future opportunities they should create in the Nanotechnology.

Geographic Segments: Each regional market is carefully examined to understand its current and future growth scenarios.

Company Profiles: The top players in the Nanotechnology market are detailed in the report based on their market share, served market, products, applications, regional growth and other factors.

The report also includes specific sections on production and consumption analysis, key results, key suggestions and recommendations, and other issues. Overall, it offers a complete analysis and research study of the Nanotechnology market to help players ensure strong growth in the coming years.

Complete Report is Available @ https://www.verifiedmarketresearch.com/product/nanotechnology-market/?utm_source=SGN&utm_medium=003

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Verified market research partners with the customer and offer an insight into strategic and growth analyzes; Data necessary to achieve corporate goals and objectives. Our core values are trust, integrity and authenticity for our customers.

Analysts with a high level of expertise in data collection and governance use industrial techniques to collect and analyze data in all phases. Our analysts are trained to combine modern data collection techniques, superior research methodology, expertise and years of collective experience to produce informative and accurate research reports.

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Tags: Nanotechnology Market Size, Nanotechnology Market Trends, Nanotechnology Market Forecast, Nanotechnology Market Growth, Nanotechnology Market Analysis

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Nanotechnology Market Size, Growth Analysis, Opportunities, Business Outlook and Forecast to 2026

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Nanotechnology Market 2020 | Growing Rapidly with Significant CAGR, Leading Players, Innovative Trends and Expected Revenue by 2026 - Skyline Gazette

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Nanotech to the rescue? – It’s All About . . . – Castanet.net

Photo: wrm.org

Cleaning up the mess with nanotechnology

Several years ago, I was in Perth, Australia talking to an engineer about a problem his company had.

He had to solve a problem with tailings ponds at an aluminum plant that had been producing aluminum for quite some time, and had been sold.

The problem with tailing ponds in any industry is typically the condensed amount of toxins. In the aluminum tailings ponds, the issue was not simply the toxic components, but the fact that the solution is extremely alkaline.

We talked about how nanotechnology could perhaps play a role. In South America, some leading nanotechnologists had developed a process to remove arsenic and cyanide from tailings ponds, which is a big problem for Canada.

However, in Australia, we extrapolated that based on the science, the nano particles of iron should be able to attract some of the toxins from the ponds, which could then be recovered and treated, leaving the ponds much cleaner.

The engineeragreed that it was probably the best solution. In fact, it was probably the only solution on the table.

The problem then? The budget required to clean the liquid ponds.

The discussion that ensues must surely be who is responsible for the clean up in these situations?

The fact is, corporations aretypically in a relationship with the government in the form of a licence fee, duties, franchise, whatever you decide to call it.

Similarly, indigenous communities often become involved based on their approval for a slice of the pie. But when it comes to pay for the clean of the environment, multiple sets of hands go up,with their owners saying it is not my problem or they pointthe finger at the next person.

In many instances, once an area has been mined, the gross proceeds from the mining operation or extraction operation do not equate to the cost of reparation.

It poses the questions why would we start in the first place?

If governments approved it and indigenous communities signed in to a business relationship, whose job is it to ensure we clean up after we have extracted and made a profit?

Regardless of the questions, in this instance, the potential to spend more than $200 million on a clean up program was not going to work.

So we asked what the solution was.

The engineer leaned on the table, looked us in the eye and said, we only have one solution;for the next 200 years, dilute the ponds slowly and carefully and release a safer and smaller amount of material into the ocean.

In my mind,that is not a solution and we should be held accountable to cleaning up our own mess.

Perhaps in the next conversation requiring the dumping of toxins into a lake, the solution will be discussed before the budget and the appropriate funds allocated before production starts.

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Nanotech to the rescue? - It's All About . . . - Castanet.net

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Destiny 2 Datamine Reveals the Return of SIVA | Game Rant – GameRant

A new Destiny 2datamine of the most recent patch has community members speculating about the return of a key piece of technology from the original Destiny. It's a return that many Destiny 2 players are going to be surprised to hear about, because the story was seemingly wrapped up in the Destiny expansion Rise of Iron. The technology is, naturally, SIVA SIVA being the Bray-developed self-replicating nanotechnology initially used by Rasputin against the Iron Lords.

The datamine in question is very interesting to consider. It's a series of file references connected by the term "felwinter." The first such reference is "mission_felwinters_lie_scanning" and the subsequent references are "o_felwinter_coffin," "o_felwinter_resurrect," "o_felwinter_fight," and most importantly "o_felwinter_siva." This is the lone reference to SIVA that dataminers have found, but is nevertheless very intriguing.

RELATED: Destiny 2 Bringing Back OP Weapon from D1?

During Destiny, the Fallen House of Devils rediscovered SIVA after it being buried since the Golden Age. Lord Saladin then formed a new generation of Iron Lords to defeat the resurrected threat and was ultimately successful. The Destiny protagonist and crew defeated the SIVA-empowered Fallen and their SIVA replication chamber. While the Guardians reportedly had everything SIVA placed under quarantine, there have been hints that it wasn't fully contained.

The new datamine indicates something worse than a SIVA outbreak, if that can be believed. Felwinter, for those unfamiliar, was an Iron Lord. More than that, he was an Iron Lord which was particularly brutal toward his enemies. The chain of filenames being coffin, resurrect, SIVA, and then fight indicates that it's possible SIVA will be bringing the Golden Age Iron Lord back, but not as a friend.

As for what form SIVA and Felwinter will be revealed in, it's anyone's best guess. Some are predicting a surprise mission toward the end of the current season, or even an Exotic weapon quest. Others think SIVA and Felwinter have a bigger role to play and will be a part of the main story for next season. The datamine shows what's presumably just a single mission, so anything's possible.

Bungie's always revisiting old story beats and introducing new ideas in Destiny 2. It's both surprising and not that SIVA will be coming back, though the scale of SIVA's return is the biggest question. It could be a brief reminder of Destiny 2's Rise of Iron expansion or it could be building toward a major threat arriving in the near or far future. Add it to the list of exciting possibilities coming to Destiny 2 eventually.

Destiny 2 is available now on Google Stadia, PC, PS4, and Xbox One.

MORE:Destiny 2: Cast in Iron Quest Steps to Get Iron Remembrance Armor, Point of the Stag Bow

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Global Nanotechnology-enabled Battery Market 2020 Industry Analysis, Future Growth, Business Prospects and Forecast 2026 – NJ MMA News

The recently launched report titled Global Nanotechnology-enabled Battery Market Insights, Forecast to 2026 analyzes the product scope, market overview, market opportunities, market driving force, and market risks. According to the report, the market has settled its presence worldwide. The report offers an in-depth evaluation of the global Nanotechnology-enabled Battery market and comprises a future trend, current growth factors, focused opinions, details, and industry certified market data. In the report, the historical, forecast data is presented as well as the complete product portfolio and company profiles of top players are mentioned. Global data, regional data, and country-level data are offered with the import-export scenario, consumption and gross margin analysis from 2015-2020 and the production rate is given in this report.

Competitive Landscape:

Here, report analysts have identified direct or indirect market competitors and at the same time, comprehended their mission, vision, core values, niche market, strengths, and weaknesses. We have provided Porters five forces including the threat of substitute products or services, established rivals, new entrants and two others such as the bargaining power of suppliers and customers. Dominating players joined with their market share are highlighted in the report. The well-established players in the global Nanotechnology-enabled Battery market are: A123 Systems, Altair Nanotechnologies, Front Edge Technology, Kokam, TOSHIBA,

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Geographical provincial information will help you in focusing on all the best-performing locales. The regions are extensively analyzed with respect to every parameter of the geographies in question, comprising, North America (United States, Canada, Mexico), Asia-Pacific (China, India, Japan, South Korea, Australia, Indonesia, Malaysia, Philippines, Thailand, Vietnam), Europe (Germany, France, UK, Italy, Russia, Rest of Europe), Central & South America (Brazil, Rest of South America), Middle East & Africa (GCC Countries, Turkey, Egypt, South Africa, Rest of Middle East & Africa)

In market segmentation by types, the report covers: Carbon , Lithium, Other

In market segmentation by applications, the report covers the following uses: Automotive, Consumer products, Other

Consumer Behavior:

Moreover, the report analyzes the behavior of the Nanotechnology-enabled Battery consumers in the marketplace and looks at motives for those behavioral trends. Additionally, personal, and social consumer behavior is studied through focus groups, surveys, and tracking sales history. Our consumer behavior study helps businesses to understand consumers value. Not all consumers value the same benefits, so its important for businesses to segment their consumer base. With using the latest technology and analysis on demand-side, key players are getting into consumer behavior and their changing preferences.

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Moreover, the report takes into account the growth rate of the global market, in addition to the consumption tables, facts, figures, and statistics of the key segments. The report states that big investment firms or giants are willing to put more capital to get a key players performance in the market for new applications or products. The research report tracks competitive growths such as joint ventures, tactical alliances, mergers and achievements, new product developments, and research and developments in the global Nanotechnology-enabled Battery market.

Customization of the Report:This report can be customized to meet the clients requirements. Please connect with our sales team (sales@marketresearchplace.com), who will ensure that you get a report that suits your needs. You can also get in touch with our executives on +1-201-465-4211 to share your research requirements.

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Global Nanotechnology-enabled Battery Market 2020 Industry Analysis, Future Growth, Business Prospects and Forecast 2026 - NJ MMA News

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