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Category Archives: Longevity Medicine

Books – Gundry MD

Most of us assume that aging means living with declining health, including prescription drugs, disease and chronic pain. So, while we may be living longer, were not living betterthats the paradox of aging.

Now, from Dr. Steven Gundry, author of the New York Times bestseller The Plant Paradox, comes a groundbreaking plan for living a long, healthy, and happy life: THE LONGEVITY PARADOX: How to Die Young at a Ripe Old Age

Working with thousands of patients, world-renowned heart surgeon and

cardiologist, Dr. Gundry has discovered that the diseases of aging

we most fear are not simply a function of age; rather, they are a byproduct of lifestyle choices over decades.

THE LONGEVITY PARADOX is the culmination of the results he has observed in patients, analysis of an enormous amount of recent research on the gut biome and his study of the worlds longest-lived communities.

In it liestrue secrets to the fountain of youth. To find out how it can help you to live your best, longest life, get your copy today!

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Longevity and Anti-Senescence Therapy Market Revolutionary Scope By 2028 EcoChunk – EcoChunk

Global Longevity and Anti-Senescence Therapy Market Size and Forecast 20212028

The Global Longevity and Anti-Senescence Therapy market is expected to reach around $800 million by 2026, with a projected CAGR of 13.9% during the forecast period.

The Longevity and Anti-Senescence Therapy report aims to analyze the market size, historic data, current data, and forecasts for various segments and countries for the forecast period. The study is performed using qualitative and quantitative analysis. The report is created by performing a deep analysis of micro and macro-economic factors that are influencing the market growth. The report includes key market trends, latest developments, product analysis, and contribution of end users to the market growth.

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The study includes detailed analysis of the key market drivers, restraints, opportunities, and challenges. It also includes information on the leading market players and strategies adopted by them in the recent years. The information includes in the report is supported by various analysis such as SWOT Analysis, Porters Analysis, Value Chain Analysis, and PESTEL Analysis. This provides a better understanding the current market size and competition on a regional and global level. The report also analyzes competitive market landscape for the Longevity and Anti-Senescence Therapy market.

The report includes information on different market segments, market structure, and future forecasts on regional basis including key information on key players in the Longevity and Anti-Senescence Therapy market. The regions studied are North America, Europe, Asia Pacific, Middle East and Africa, and South America. The study includes information on the products offered by the key players, recent developments and strategies adopted by them to hold the position. The information provided in the Longevity and Anti-Senescence Therapy market report is analyzed and verified by industry experts.

The study will include the overall analysis of the Longevity and Anti-Senescence Therapy Market and is segmented

By Therapy

By Application

Some of the leading players profiled in the report are

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Impact of COVID-19 on Longevity and Anti-Senescence Therapy Market

Our analysts have studied the impact of COVID-19 pandemic on the Longevity and Anti-Senescence Therapy market. The report includes information on the pre and post impact of the pandemic on the market and the strategies adopted by the key players to recover the losses.

Objectives of the Longevity and Anti-Senescence Therapy Market Report

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Longevity and Anti-Senescence Therapy Market Revolutionary Scope By 2028 EcoChunk - EcoChunk

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New York Times: How Much Exercise Do We Need to Live Longer? – Saint Luke’s Health System

Two large-scale new studies of the relationship between physical activity and longevity show that the right types and amounts of physical activity reduce the risk of premature death by as much as 70 percent.

The two studies also suggest that there can be an upper limit to the longevity benefits of being active, and pushing beyond that ceiling is unlikely to add years to our life spans and, in extreme cases, might be detrimental.

Dr. James OKeefe, director of preventive cardiology atSaint Lukes Mid America Heart Institute and a professor of medicine at the University of Missouri-Kansas City, was an author on one of the studies. The study,published in August in Mayo Clinic Proceedings, asked tens of thousands of participants how many hours they exercised a week.

The very active group, people doing 10-plus hours of activity a week, lost about a third of the mortality benefits, compared to people exercising for 2.6 to 4.5 hours a week," Dr. O'Keefe said.

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Minorities Bore the Brunt of US COVID Deaths – WebMD

By Steven Reinberg HealthDay Reporter

TUESDAY, Oct. 5, 2021 (HealthDay News) -- The ongoing coronavirus pandemic has hit minority groups in the United States hard, with significantly more deaths among Black and Hispanic Americans compared with white and Asian Americans, a new study finds.

According to the report, these disparities highlight the need to address ongoing inequities influencing health and longevity in the United States.

What's more, "focusing on COVID-19 deaths alone without examining total excess deaths that is, deaths due to non-COVID-19 causes as well as to COVID-19 may underestimate the true impact of the pandemic," added study author Meredith Shiels. She's a senior investigator at the U.S. National Cancer Institute.

For the study, the researchers compared excess deaths by race/ethnicity, sex, age group and cause of death from March to December 2020 with data from the same months in 2019. The team used provisional death certificate data from the U.S. Centers for Disease Control and Prevention and population estimates from the U.S. Census Bureau.

The findings showed that nearly 3 million people died in the United States between March 1 and Dec. 31, 2020. Compared with the same period in 2019, that totaled 477,200 excess deaths, with 74% of these excess deaths being due to COVID-19.

After taking age into account, the numbers of excess deaths by population size among Black, American Indian/Alaska Native, and Hispanic men and women were more than double those in white and Asian American men and women, according to the report.

The data do not explain the reasons for the excess non-COVID deaths. "It is possible that fear of seeking out health care during the pandemic or misattribution of causes of death from COVID-19 are responsible for a majority of the excess non-COVID-19 deaths," Shiels said in a news release from the U.S. National Institutes of Health.

The excess deaths that occurred during the pandemic have resulted in growing disparities in overall U.S. death rates, with the gap in age-adjusted all-cause deaths increasing between 2019 and 2020 for Black and American Indian/Alaska Native men and women compared with white men and women.

For example, the investigators found that in 2019, total deaths by population among Black men was 26% higher than in white men, but in 2020 it was 45% higher. The same held true for women. In 2019, total deaths by population among Black women was 15% higher than in white women, but in 2020 it was 32% higher, according to the report published Oct. 5 in the Annals of Internal Medicine.

Resistance to vaccination could be one big contributing factor.

Study co-author Dr. Eliseo Prez-Stable is director of the U.S. National Institute on Minority Health and Health Disparities. He said, "Our efforts at NIH to help mitigate these COVID disparities have been heavily focused on promoting testing and vaccine uptake through community-engaged research. However, vaccine hesitancy poses a real threat, so we are addressing the misinformation and distrust through collaborative partnerships with trusted community stakeholders."

More information

For more on COVID-19, head to the U.S. Centers for Disease Control and Prevention.

SOURCE: U.S. National Institutes of Health, news release, Oct. 4, 2021

WebMD News from HealthDay

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NHS approves revolutionary drug for sickle cell disease; first in 20 years – Republic World

In a major breakthrough, National Health Service (NHS) has approved the first drug for sickle cell disease in 20 years. The "revolutionary" treatment, called the Crizanlizumab, will help over 5,000 people with the condition in the next three years, NHS said in a statement. It will also slash the number of times a sickle cell disease patient needs to go to A&E by two-fifths.

"This is a historic moment for people with sickle disease who will be given their first new treatment in over two decades. This revolutionary treatment will help to save lives, allow patients to have a better quality of life and reduced trips to A and E by almost half," NHS Chief Executive Amanda Pritchard said in a statement.

The drug prepared by Novartis was tested over a limited number of patients, thus, leaving open ends for judging its longevity. Crizanlizumab treatment involves injecting the medicine into the vein alongside standard treatment and regular blood transfusions. According to the National Institute of Health and Care Excellence (NICE), clinical evidence suggests that people treated with Crizanlizumab had significantly fewer sickle cell crises in a year than those receiving other standard treatment options.

"Crizanlizumab is an innovative treatment that has shown the potential to improve hundreds of lives, and we are delighted to be able to recommend it as the first new treatment for sickle cell disease," Meindert Boysen, deputy chief executive and director of the Centre for Health Technology Evaluation at NICE said in a statement.

All patients above 16 years of age who suffer from sickle disease will be eligible for the Crizanlizumab treatment. Also, the drug will be available to the patients "at a price that is affordable to the taxpayers," Pritchard added. "A new treatment brings new hope for people living with sickle cell disorder, the world's most common genetic blood condition," Sickle Cell Society chair Kye Gbangbola told Evening Standard. She also explained how SCD is a medical emergency and causes excruciating pain. "(This) new treatment will reduce the number of agonising pain episodes we have to endure," she added.

Sickle cell disease is the name for a group of inherited health conditions that affect red blood cells. The most serious type is called sickle cell anaemia. As per NHS, it is particularly observed in people with African or Caribbean family backgrounds.

People affectedwith sickle cell disease produce unusually shaped red blood cells that can cause problems because they do not live as long as healthy blood cells and can block blood vessels. The most common symptoms of the disease are: painful episodes called sickle cell crises, which can be very severe and last up to a week; an increased risk of serious infections; anaemia (where red blood cells cannot carry enough oxygen around the body), which can cause tiredness and shortness of breath. Sickle cell disease is caused by a gene that affects how red blood cells develop.

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NHS approves revolutionary drug for sickle cell disease; first in 20 years - Republic World

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Characterization of overgrown toes in sow breeding herds – National Hog Farmer

Breeding herd mortality and replacement rates continue to be challenging areas for commercial swine producers. Breeding sow herd lameness is a major contributor to mortality challenges, feet and leg conformation and lameness. Feet and leg structure rank right behind reproductive failure as the major identifiable reason for sow culling and reduced sow longevity.

Overgrown toes, often called digital overgrowth in scientific circles, continues to represent an increasing breeding sow herd challenge. Overgrown toes are one of the most common foot abnormalities seen and recorded on commercialized sow farms, and often lead to lameness and premature sow culling. In addition, sows with severe toe overgrowth may have impaired welfare and this in-turn could erode consumer confidence.

It has been reported that just under 10% of lactating sows had overgrown toes (KilBride et al, 2010). In another study that included 3,500-plus pregnant sows, over 25% had moderately overgrown toes, while 7% had severely overgrown toes (Boyle, 1996). Overgrown toes can negatively impact sow performance because sows spend less time eating and are quicker to lay down post farrowing when compared to sows with normal toe growth (Calderon Diaz et al., 2015). In addition, Calderon Diaz and colleagues (2015) reported that sows with overgrown toes had higher instances of slipping and weight shifted frequently. Collectively, these behaviors and postural changes indicate a sow in greater discomfort. Beyond discomfort, the actions of slipping and being quicker to lay down may be related to increased piglet crushing and greater pre-wean mortalities. Fitzgerald et al. (2012) reported that sows with overgrown toes averaged 1.5 fewer piglets born alive when compared to control sows without digital overgrowth. The overall combination of sow discomfort, lower feed intake, lower number born alive and greater piglet crushing contributes to poorer sow performance and reduced breeding herd efficiency (Lucia et al., 2000). The sows age/number of parities may also play a role with overgrown toes in the breeding herd. Knauer et al. (2012) reported that 8% of parity 1 sows had overgrown toes on their rear feet, but between parities 6 through 10 this number increased to 40%. Interestingly, sows culled with overgrown toes on the front feet were much lower, with 0% for parity 1 sows and approximately 5% between parities 6 through 10 (Knauer et al., 2012).

Sows with overgrown toes tend to have a greater risk for developing other foot problems like cracks in the toes and lesions (Lisgara et al., 2014). Furthermore, overgrown dew claws may become concave, extremely curved or extend below the heel bulb that in-turn and contribute to increased lameness. In a study evaluating sow lesions at the harvest plant, Knauer et al. (2007) observed that 86% (n=3,158) had a lesion on at least one foot. Additionally, 52% of sows had at least one lesion on their front feet and 81% had at least one lesion on their rear feet. The same study speculated that increased rear foot lesions may be attributed to the wet environment that sows are exposed to in a gestation stall.

Another factor contributing to overgrowth toes relates to weight bearing on their feet. Approximately 80% of the sows weight of the sow is born by the outside (lateral) toe and the majority of the weight on that toe being placed on the heel bulb (Webb, 1984). The uneven weight distribution on the feet as well as the difference in weight distribution between the outside (lateral) and inside (medial) toes (Sasaki et al., 2015) likely contribute to the uneven toe wear that can contribute to overgrown toes in the sow breeding herd.

As the sows toes and dewclaws become overgrown, there is an increased risk that they may getting caught in slotted flooring and break off creating lameness issues (Pluym et al., 2013b). If a sows dewclaw becomes detached, the highly innervated corium (like the nail bed in humans) is exposed and results in a very painful lameness condition (Pluym et al., 2011; Pluym et al., 2013b). The risk for this occurrence increases in group-housed sow gestation settings where the biological demand increases because sows are competing for resources and increased locomotion occurs (Anil et al., 2003; Pluym et al., 2013b; Tinkle et al., 2017).

Histologically, there are differences when comparing foot and toe structure from sows feet with overgrown toes with sows having normal appearing toes. A variety of factors including body weight, weight distribution, trauma, fighting, housing type and the interaction among two or more factors play a role in differing foot structures that contribute to overgrown toes observed among breeding herd females (Newman et al., 2014). Newman et al. (2014) evaluated 24 Landrace x Large White F1 females to study cellular and toe structure. They defined overgrowth as claws that were greater than 50mm long. Their results indicated that of the 72 claws evaluated, 39 showed digital overgrowth while the remainder showed normal appearing toe growth. Overgrown toes ranged between 51 mm and 79 mm in length. Lateral rear claws comprised 67% of all overgrown toes. Laminitis was found in several toe tissue samples when evaluated microscopically from sows presenting overgrown toes. Inflammation was observed from 14 of the sows with overgrown toes, but total numbers were insufficient to create statistical significance.

It is clear that overgrown toes can be a challenge for commercial sow breeding herds. We know that overgrown toes can contribute to increased locomotion challenges and reduced sow performance in the breeding herd. Additionally, overgrown toes can be a welfare issues when toe overgrowth is excessive and/or when toes breakoff. This may cause injury or lameness. To date, identifying the cause for overgrown toes within commercial sow herds is challenging and is an area our research group is focusing on in the coming months.

Sources:Derek Henningsen, Grace Moeller, Anna Johnson, Locke Karriker, and Ken Stalder, Iowa State University,who aresolely responsible for the information provided, and wholly own the information. Informa Business Media and all its subsidiaries are not responsible for any of the content contained in this information asset.

References

Anil, L., K. M. G. Bhend, S. K. Baidoo, R. Morrison, and J. Deen. 2003. Comparison of injuries in sows housed in gestation stalls versus group pens with electronic sow feeders. J. Am. Vet. Med. Assoc. 223:13341338. doi:10.2460/javma.2003.223.1334.

Boyle, L., MSc. thesis 1996. Skin Lesions, Overgrown Hooves and Culling Reasons in Individually Housed Sows. University College Dublin, Dublin, Ireland.

Caldern Daz, J.A., Stienezena, I.M.J., Leonard, F.C., Boyle, L.A., 2015. The effect of overgrown claws on behaviour and claw abnormalities of sows in farrowing crates. Applied Animal Behaviour Science 166, 44-51.

Fitzgerald, R.F., Stalder, K.J., Karriker, L.A., Sadler, L.J., Hill, H.T., Kaisand, J., Johnson, A.K., 2012. The effect of hoof abnormalities on sow behavior and performance. Livestock Science 145, 230238.

KilBride, A.L., Gillman, C.E., Green, L.E., 2010. A cross-sectional study of prevalence and risk factors for foot lesions and abnormal posture in lactating sows on commercial farms in England. Anim. Welf. 19, 473480.

Knauer, M., K. J. Stalder, L. Karriker, T. J. Baas, C. Johnson, T. Serenius, L. Layman, and J. D. McKean. 2007. A descriptive survey of lesions from cull sows harvested at two Midwestern U.S. facilities. Prev. Vet. Med. 82:198212. doi:10.1016/j.prevetmed.2007.05.017.

Knauer, M., Stalder, K., Baas, T., Johnson, C., Karriker, L., 2012. Physical conditions of cull sows associated with on-farm production records. Open Journal of Veterinary Medicine, 2012, 2, 137-150.

Lisgara, M., Skampardonis, V., Kouroupides, S., Leontides, L., 2014. Hoof lesions and lameness in sows in three Greek swine herds. Journal of Swine Health and Production. 23, 5, 244-251.

Lucia, T., Dial, G.D., Marsh, W.E., 2000. Lifetime reproductive and financial performance of female swine. J. Am. Vet. Med. Assoc. 216, 18021809.

Newman, S.J., Rohrbach, B.W., Wilson, M.E., Torrison, J., Van Amstel, S., 2014. Characterization of histopathological lesions among pigs with overgrown claws. Journal of Swine Health and Production. 23, 2, 91-96.

Pluym, L., A. Van Nuffel, J. Dewulf, A. Cools, F. Vangroenweghe, S. Van Hoorebeke, and D. Maes. 2011. Prevalence and risk factors of claw lesions and lameness in pregnant sows in two types of group housing. Vet. Med. (Praha). 56:101109. doi:10.17221/3159-VETMED.

Pluym, L., A. Van Nuffel, and D. Maes. 2013b. Treatment and prevention of lameness with special emphasis on claw disorders in group-housed sows. Livest. Sci. 156:3643. doi:10.1016/j.livsci.2013.06.008.

Sasaki, Y., R. Ushijima, and M. Sueyoshi. 2015. Field study of hind limb claw lesions and claw measures in sows. Anim. Sci. J. 86:351357. doi:10.1111/asj.12299.

Tinkle, A. K., K. J. Duberstein, M. E. Wilson, M. A. Parsley, M. K. Beckman, J. Torrison, M. J. Azain, and C. R. Dove. 2017. Functional claw trimming improves the gait and locomotion of sows. Livest. Sci. 195:5357. doi:10.1016/j.livsci.2016.10.013.

Webb, N. G. 1984. Compressive stresses on, and the strength of the inner and outer digits of pigs feet, and the implications for injury and floor design. J. Agric. Eng. Res. 30:7180. doi:10.1016/S0021-8634(84)80008-6

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Characterization of overgrown toes in sow breeding herds - National Hog Farmer

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