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Global Precision Medicine Software Market in-Depth Analysis, Key Players, Challenges, Segmentation and Forecasts to 2027. – The Think Curiouser

Latest updated Report gives analysis of Precision Medicine Software market overview, scope, market risks, market driving force and market opportunities. Precision Medicine Software competitive situation, sales, revenue and global market share of top manufacturers working in Precision Medicine Software industry are analyzed clearly by landscape contrast

The Global Precision Medicine Software Market divides the industry on the basis of the regions by growth, product types and applications, over the forecast period (2020-2027) of the Precision Medicine Software market. It analyzes every majorfacts of the global Precision Medicine Software by specifications of the product, restraints, challenges, andgrowth opportunities. Company profiles of the major leading player with Precision Medicine Software investment forecast, latest technology trends,and future forecast. Detailed global understanding of the Precision Medicine Software market based on present and future size(revenue) and Precision Medicine Software market prediction plot in the form of a list of charts and tables, pie-charts to assist aspirants and major market players in making significant and growing choices.

Download Free Sample Pdf Report @ https://www.globalmarketers.biz/report/others/2015-2027-global-precision-medicine-software-industry-market-research-report,-segment-by-player,-type,-application,-marketing-channel,-and-region/146709#request_sample

The research mainly covers Precision Medicine Software market in North America (United States, Canada and Mexico), Precision Medicine Software Europe industry (Germany, France, UK, Russia and Italy), Asia-Pacific (Southeast Asia, China, Korea, India and Japan), Precision Medicine Software South America industry (Brazil, Argentina, Colombia), Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa). The Precision Medicine Software report also performs SWOT (Strengths, Weaknesses, Opportunities, and Threats) with XX CAGR values, and XX USD of past(2015-2019) and Precision Medicine Software forecast(2020-2027) on the basis of growth and market condition following with the size of Precision Medicine Software market.

The Global Precision Medicine Software market reportcomprises variouskey manufacturers, application analysis and type analysis:

Key players of the global Precision Medicine Software market:

Abbott Laboratories(US)Syapse, Inc. (US)Roper Technologies(US)Sunquest Information Systems Inc. (US)Pfizer, Inc., Merck & Co., Inc.(US)N-of-One, Inc. (US)NantHealth, Inc. (US)LifeOmic Health, LLC (US)Fabric Genomics (US)Allscripts(US)GlaxoSmithKline plc(UK)Gene42, Inc. (Canada)Foundation Medicine, Inc. (US)Koninklijke Philips N.V. (Netherlands)PierianDx, Inc. (US)Translational Software, Inc. (US)Flatiron Health, Inc. (US)IBM Watson Group (US)Sanofi S.A.(France)Tempus Labs, Inc. (US)AstraZeneca plc(US)2bPrecise LLC (Israel)Qiagen(Germany)SOPHiA GENETICS SA (Switzerland)Human Longevity, Inc. (US)

Market Segment Analysis

By Types:

Cloud-basedOn-premise

By Applications:

Healthcare providersResearch centers & Government institutesPharmaceutical & Biotechnology companiesOther end users

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Segments of the Precision Medicine Software Report:

Global Precision Medicine Software market report figure out a detailed analysis of key Precision Medicine Software market players by referencing their company profiles, supply/demand study, sales margin, gross margin and year to year revenue to have Precision Medicine Software industry better share over the globe. Precision Medicine Software market report also includes development.

The Global Precision Medicine Software industry research report analyses the supply, sales, production, and market status comprehensively. manufacturing market shares and sales market shares are analyzed along with the analysis of capacity, production, sales, and revenue.

Table Of Content Described:

1. Precision Medicine Software Industry Synopsis

2. Global Precision Medicine Software Market Size by Segmentation (2020-2027)

3. Precision Medicine Software Leading Manufacturers Company Profiles

4. Global Precision Medicine Software Market Competitive Study by Players

5. US Precision Medicine Software Market Development Status and Overview

6. Europe Precision Medicine Software Market Improvement Status and Overview

7. Africa Precision Medicine Software Market Development Status and Overview

8. South-America Precision Medicine Software Market Improvement Status and Overview

9. Asia-pacific Precision Medicine Software Market Development Status and Overview

10. Southeast Asia Precision Medicine Software Improvement Status and Overview

11. Precision Medicine Software Market Forecast by Regional Analysis, And By Segmentation (2020-2027)

12. Dynamics of Precision Medicine Software Market

13. Precision Medicine Software Market Growth Factors Study

14. Research Conclusions

15. Appendix

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Global Precision Medicine Software Market in-Depth Analysis, Key Players, Challenges, Segmentation and Forecasts to 2027. - The Think Curiouser

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Next Avenues 2020 Influencers In Aging Fight Covid-19, Loneliness And Ageism – Forbes

By Next Avenue Editors

Next Avenue

For the past six years, Next Avenue public medias first and only national journalism service for Americas older population has released a list of Influencers in Aging.

Weve named 20 trailblazers who are each uniquely changing how we age and think about aging. This years list includes a new and distinctive group of five honorees specifically chosen for their contributions to advance the safety and wellness of older Americans during the Covid-19 pandemic.

The coronavirus pandemic changed pretty much everything in 2020 and that goes for how we chose this year's Next Avenue Influencers in Aging and why.

As we all know, the pandemic has been cataclysmic to people's lives and exposed major gaps in government and health care policies, institutions and services. Disturbingly, the pandemic has also amplified ageism and negative stereotypes of aging. These and other effects of COVID-19 will continue for months, if not years.

Next Avenues 2020 Influencers in Aging are:

Jean Accius senior vice president of AARP Global Thought Leadership. He led the AARP team to produce The Longevity Economy report documenting the enormous dollar value of Americans 50+.

Angela Burton founder of Feet to the Fire Writers' Workshops a creative program that inspires adults to challenge themselves through expressive writing. Her work inspires creative action that enhances the lives of thousands of older adults.

Christina Da Costa senior director of communications at SAGE, a national advocacy and services organization thats been looking out for LGBT elders since 1978. She led groundbreaking work that used technology to connect vulnerable adults to community leaders and allies during the pandemic.

Robert Espinoza vice president of policy at PHI, where he oversees its national policy advocacy, research and public education division. PHI promotes and advocates for quality direct care jobs. Espinozas work has revealed and worked to correct inequities in the direct care workforce, predominantly made up of women, people of color and immigrants.

Michael J. Fox Canadian-born actor, author and advocate who has navigated a five-decade career in entertainment and lived with Parkinsons disease since 1991. He has become the face of millions who live with chronic degenerative diseases and a champion for funding research that advances treatment options.

Dr. Sharon Inouye director of the Aging Brain Center at Hebrew SeniorLife and professor of medicine at Harvard Medical School. She has become one of the nations leading experts during the pandemic on the need to include older adults in COVID-19 vaccine trials. Dr. Inouye is also an internationally recognized leader in aging and geriatric medicine. Her work focuses on delirium in hospitalized older patients, with more than 300 peer-reviewed original articles to date.

Charlotte Japp The millennial founder of CIRKEL, an intergenerational platform that aims to connect younger and older workers in shared learning and networking opportunities. Her work is helping older professionals stay in the workforce longer and impart valuable mentorship to younger workers and vice versa.

Raymond Jetson An Encore Public Voices Fellow who leads MetroMorphosis in Baton Rouge, La. and is urging older Black men to mentor younger Black adults and youth. His organization mobilizes engaged citizens in inner-city neighborhoods to design and implement sustainable solutions to persistent community challenges.

Heidi Johnson director of behavioral economics at Financial Health Network. She wrote a breakthrough report on personal finance technology use and needs of lower-income older Americans. At FNN, Johnson leads work to leverage behavioral insights in the design and development of products that support consumers financial health, including retirement planning.

Stephen Johnston Co-founder of Aging2.0, a global innovation platform for aging that connects entrepreneurs, care providers and older adults to identify and build solutions to help people age better.

Dr. Dominic H. Mack Professor of family medicine at Morehouse School of Medicine and co-director of The National COVID-19 Resiliency Network, which assembles local, state and national partners to reduce the impact of COVID-19 on vulnerable populations.

Grandpa Chan and Grandma Marina Husband and wife from South Korea, Chan Jae Lee and Kyong Ja Ahn became internationally recognized for their virtual storytelling, which began as a way to connect with their four grandchildren. The couple just published a book (Looking Back, Life was Beautiful), regularly delight their 400,000 Instagram followers with original stories, videos and illustrations and have been featured by The New York Times NYT and BBC.

Dr. Vivek Murthy Former Surgeon General of the United States who has focused on chronic stress and isolation as prevalent problems that have profound implications for health, productivity and happiness.His 2020 book Together: The Healing Power of Human Connection in a Sometimes Lonely World underscores the detrimental effects of loneliness and calls for resources and innovation to combat it. He is also co-chair of President-Elect Biden's COVID-19 Transition Task Force.

Dr. Jeremy Nobel Founder and president of the Foundation of Art & Healing, and architect of the UnLonely Project that was created in response to the growing public health concern of social isolation and loneliness. The initiative broadens public awareness of the negative physical and mental health consequences of loneliness associated with a wide range of living conditions and promotes creative arts-based approaches to reduce the burden.

Michael Osterholm Director of the Center for Infectious Disease Research and Policy at the University of Minnesota, where he has provided public health guidance to government agencies and media outlets during the COVID-19 pandemic. He is a former Minnesota state epidemiologist and author of the New York Times best-selling 2017 book, Deadliest Enemy: Our War Against Killer Germs. He is also a member of President Biden's COVID-19 Transition Task Force.

Sian-Pierre Regis Award-winning journalist and cultural critic who directed the feature-length documentary Duty Free about his immigrant mother, who was abruptly fired from her job as a hotel housekeeper at the age of 75, and the economic insecurity facing her and millions in her generation.

Jason Resendez Executive director of the Latinos Against Alzheimers Network. He is a leader in the nations efforts to address brain health disparities impacting Latinos. Resendez spearheads coalition building, strategic convening and patient advocacy in the Latino community.

Andrew Saul Commissioner of the Social Security Administration, who has made customer service a top priority for Social Security beneficiaries, including adding more than 1,000 staffers to answer questions on the agencys toll-free line and improving its website so Americans can better see and understand the Social Security benefits theyll receive.

Jennifer Sheets President and CEO of Interim Healthcare. She worked with the White House in 2020 to advocate that home care clinicians receive essential workers status.

C. Grace Whiting President and CEO of The National Alliance for Caregiving. Whiting has been a leader in research around caregiving in America, producing the nations first national policy study of 1,400+ rare disease caregivers with Global Genes and helped author AARPs Caregiving in the U.S. 2020 report.

When you read our interviews with this year's winners and see the video and audio clips from them in our articles, we think you'll see why the 2020 Influencers in Aging are a remarkable, spirited group with groundbreaking achievements.

Be sure to read, at the end of each interview, the Influencer in Aging's answers to two questions we asked them all:

If you could change one thing about aging in America, what would it be

How has the COVID-19 pandemic changed your perspective on aging?

Their responses will tell you a lot about why these insightful honorees made the cut for 2020. We could not be more excited to uplift the work of these extraordinary people who are tackling these questions and finding new ways for living longer, healthier and happier lives.

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12-minute bursts of exercise have bigger impact than thought – Harvard Gazette

Short bursts of physical exercise induce changes in the bodys levels of metabolites that correlate to an individuals cardiometabolic, cardiovascular, and long-term health, a study by Harvard-affiliated Massachusetts General Hospital (MGH) has found.

In a paper published inCirculation, the research team describes how about 12 minutes of acute cardiopulmonary exercise affected more than 80 percent of circulating metabolites, including pathways linked to a wide range of favorable health outcomes, thus identifying potential mechanisms that could contribute to a better understanding of cardiometabolic benefits of exercise.

What was striking to us was the effects a brief bout of exercise can have on the circulating levels of metabolites that govern such key bodily functions as insulin resistance, oxidative stress, vascular reactivity, inflammation, and longevity, said investigator Gregory Lewis, section head of Heart Failure at MGH and senior author of the study.

The MGH study drew on data from the Framingham Heart Study to measure the levels of 588 circulating metabolites before and immediately after 12 minutes of vigorous exercise in 411 middle-aged men and women.

The research team detected favorable shifts in a number of metabolites for which resting levels were previously shown to be associated with cardiometabolic disease. For example, glutamate, a key metabolite linked to heart disease, diabetes, and decreased longevity, fell by 29 percent. And DMGV, a metabolite associated with increased risk of diabetes and liver disease, dropped by 18 percent. The study further found that metabolic responses may be modulated by factors other than exercise, including a persons sex and body mass index, with obesity possibly conferring partial resistance to the benefits of exercise.

Intriguingly, our study found that different metabolites tracked with different physiologic responses to exercise, and might therefore provide unique signatures in the bloodstream that reveal if a person is physically fit, much the way current blood tests determine how well the kidney and liver are functioning, notes co-first author Matthew Nayor of the Heart Failure and Transplantation Section in the Division of Cardiology at MGH. Lower levels of DMGV, for example, could signify higher levels of fitness.

The Framingham Heart Study, which began in 1948 and now embraces three generations of participants, allowed MGH researchers to apply the same signatures used in the current study population to stored blood from earlier generations of participants. By studying the long-term effects of metabolic signatures of exercise responses, researchers were able to predict the future state of an individuals health, and how long they are likely to live.

Were starting to better understand the molecular underpinnings of how exercise affects the body and use that knowledge to understand the metabolic architecture around exercise response patterns, says co-first author Ravi Shah of the Heart Failure and Transplantation Section in the Division of Cardiology at MGH. This approach has the potential to target people who have high blood pressure or many other metabolic risk factors in response to exercise, and set them on a healthier trajectory early in their lives.

Lewis is associate professor of medicine at Harvard Medical School and director of the Cardiopulmonary Exercise Testing Laboratory at MGH. Nayor is a cardiologist at MGH and instructor of medicine at Harvard Medical School, and Shah is a cardiologist at MGH and assistant professor of medicine at Harvard Medical School. Other co-authors include Ramachandran Vasan, professor of medicine at Boston University and principal investigator of the Framingham Heart Study, and Clary Clish, senior director of Metabolomics at the Broad Institute of MIT and Harvard.

The study was supported by the American Heart Associations Grand Challenge Award and the National Institutes of Health.

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WWII veteran just shy of his 100th birthday says his secret to longevity is his wife – and vodka – USA TODAY

World War II veteran Frank Caruso, 99, and his wife, Ann, 94, at The Fountains assisted living facility in Tuckahoe looks on Nov. 2, 2020. Caruso will turn 100 years-old on Nov. 19. Rockland/Westchester Journal News

WHITE PLAINS, N.Y. Wednesdayis Veterans Day, when Americaremembers those who served in its armed forces.

Frank Caruso served in World War II. And this Veterans Day, just eight days shy of his 100th birthday, his memory still serves him remarkably well.

When asked for the secret to his longevity and happy life, he turns to Anna, his wife of 72 years.

"There she is," he said. "There's the secret."

Then Carusooffersanother suggestion.

"I have a longevity medicine," he said. "One Absolut vodka martini a day, just one, with a drop of Vermouth and no fruit."

Caruso's stories fly with flecks of tantalizing detail, from the shadow of Italy's Mount Vesuvius to "Mad Men"-era New York and beyond.

World War II veteran Frank Caruso, 99, with his wife Ann, 94, at The Fountains assisted living facility in Tuckahoe Nov. 2, 2020. The couple have been married for 72 years and Caruso will be a 100 years-old on Nov. 19.(Photo: Tania Savayan/The Journal News)

"I have to think, 'What era did I do that in?' because I sort of had separate different lives that I've lived through the years," Caruso said. "You try to remember them in groups."

Each "group" is well-represented as Caruso speaks, inching his wheelchair forward, a storyteller eager to be closer to his audience at a New York retirement home.

There were the early years in Detroit, before his tailor-father Michele Caruso, a native of Abruzzo, Italy, moved the family to the Bronx in 1929. Then came the Depression and his war years in the Army service that found him in Rome, shaking hands withPope Pius XII.

Cpl. Francis J. Caruso went from working at the Brooklyn Navy Yard in 1942 to 30 months in overseas service in U.S. Army in World War II, in North Africa, Italy and Corsica.(Photo: Submitted)

After the war came his wife, Anna, and their two children.

Caruso spent years as a commercial artist on New York City'sMadison Avenue. From 1956 to 1987, he worked in commercial packaging for American Can Company, in Midtown Manhattan and, later, Greenwich, Connecticut.

That he has lived 99 years and 51 weeks through war and, now pandemic is remarkable.The U.S. Department of Veterans Affairs estimates that fewer than 325,000 of the 16 million Americans who served in World War II are still alive.

He wears a mask out of deference to the coronavirus pandemic which has hit the elderly hardest, accounting for 171,814 deaths of those age65 or older, according to the Centers for Disease Control and Prevention.

When Caruso remembers his military service as an artillery instrument operator, siting shellsin Gen. Mark Clark's Fifth Army inNorth Africa and the invasion of Italyhis memories arepart battle objectives, part weather report.

"You listen to artillery shells all day long, back and forth," he said. "The Germans shelling, the Americans shelling all day."

Caruso moved onto Corsica and on toSalerno, as the Americans worked theirway up Italy's "boot." There was time spent in Naples, where, at night, he could see flames rising from a simmering Mount Vesuvius.

There was, by Caruso's account, all kinds of weather, conjuring images from Pulitzer Prize-winning cartoonist BillMauldin, whose workregularly depicted soggy GIs in flooded foxholes.

Caruso's basic training was on "bitter cold Cape Cod," followed by a landing in North Africa, "where it was 120 degrees in the shade."

Cpl. Francis J. Caruso lent his artistic talents to the war effort during the 30 months he spent overseas in World War II. Here's one of his creations, emblazoned on the side of a B-25 bomber(Photo: Submitted)

Caruso found time for one non-artillery assignment in Corsica while waiting for the storming of Italy: Knowing that Caruso was an artist, afriend volunteeredhimto decorate a B-25 bomber nicknamed Sahara Sue II.

Caruso remembered having to scour the airfield for paints and brushes before spendingtwo weeks or so to emblazon the plane with a leggy lady.

Last year, 76 years later, Caruso met aretired Air Force officer at New York's Westchester County Airport, where World War II-era aircraft were on display. Within hours of mentioning that long-ago painting assignment to the officer, "I came home and he flipped this onto my computer."

A photo of Sahara Sue II.

"He found this plane," Caruso said, his voice full of awe. "Of all the thousands of planes we had."

First-generation American and World War II veteran Frank Caruso, 99, talks about his life experiences Nov. 2, 2020 at The Fountains assisted living facility in Tuckahoe. Caruso will turn 100 years-old on Nov. 19.(Photo: Tania Savayan/The Journal News)

The Americans fought north from Salerno to Naples and onto another key objective: the monastery atop Monte Cassino.

Bombing was finally approved on Feb. 15, 1944.

"I remember that day very vividly, because it felt like every plane in Italy was in the air dropping bombs," Caruso recalled. "And after it was all through, the Germans still had it. It was so well guarded. They had to go up on foot, climb up the side of mountain on foot to take it eventually."

When the war in Europe ended, Caruso was in Pisa, within walking distance of the leaning tower. V-E Day in May 1945 wasn't a big blowout for GIs still in Italy, he recalled.

When a visitor expresses surprise that the end of the war in Europe didn't launch a huge party, Caruso offers a simple defense: "Well, they didn't have much good booze," he said. "They mostly had cordials."

There was another war, still raging in May 1945 when Germany surrendered.

"The big fear we all had was that when the war ended in Europe we were going to be shipped to Japan," he said. But the point system years of service overseas and combat service pins meant Caruso was sent home.He was discharged in November 1945.

When he returned to the Bronx, he had spent 30 months overseas.

"That was a pretty rough deal, I think, for anybody," he said. "Nobody could go home those days. They didn't have rotations."

After his war service, Frank Caruso earned an advertising degree from Pratt Institute and worked for a NYC advertising agency before landing a job at American Can Company in New York and, later, Greenwich. where he stayed for 31 years. Frank Caruso will mark his 100th birthday on Nov. 19, 2020.(Photo: Submitted)

Back in the Bronx, arelative introduced Caruso "to a school chum" of Anna Pace. Before long, he and Pace were dating. They married on Feb. 7, 1948.

He earned his Pratt Institute advertising design degree at night while working for a Manhattan ad agency, then he got a job in package design for American Can Company, where he stayed for 31 years, from 1956 to 1987.

His portfolio brims with designs for Fanta soda and Schlitz cans, including print ads that would find their way into glossy magazines and newspapers.

Duringthose Midtown "Mad Men" years,Carusodeveloped a cherished ritual that he said was one of his secrets to a long life: a single vodka martini a day.

It was a habit he developed on New York City's Madison Avenue. He said heloved working in Midtown in that post-war era, where lunches were regularly accompanied by a cocktail.

"Madison Avenue was known for its swingers and everything else, and for a long time, everybody drank Manhattans," he said. "But here's the secret: You drink aManhattan, you come back, they can smell you a half-a-mile away. You drink a vodka martini, they can't tell. That's how it became popular. That's the truth."

Caruso shrugs when asked if his war years those months spent in all kinds of weather, seeing comrades fall affected him, made him the man he became.

"I don't know about that, truthfully," he said. "Maybe I was too young. It didn't affect me that much. Overseas was a long time, but I survived. A lot of guys didn't survive."

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Late-Breaking Study Results of the Supreme HT Healing-Targeted DES Demonstrated Equivalent Outcomes with Exceptional Safety – PRNewswire

The PIONEER III study enrolled 1,629 patients (randomized 2:1 experimental to control) from North America, Europe and Japan and had a primary composite endpoint of target lesion failure (TLF) at one-year. The TLF outcomes showed that the Supreme HT met the non-inferiority endpoint at 5.4% compared to 5.1% from the DP DES (p=0.002). A grouped analysis of secondary endpoints showed a numerically better result for Supreme HT in cardiac death or target-vessel myocardial infarction (TV MI) with 3.5% in the Supreme HT arm compared to 4.6% in the control arm (p=0.27). Lower late stent thrombosis data (Supreme HT 0.1% compared to DP DES 0.4%, p=0.22) also suggested exceptional safety for the HT DES. A powered, landmark TLF analysis evaluating the healing superiority of Supreme HT between 1 and 5 years is ongoing.

"I am very pleased that Japanese patients will benefit from the most advanced DES in the US, Europe and Japan," said Shigeru Saito, MD, Shonan Kamakura General, Japan and primary investigator of the Japanese cohort of the PIONEER III study . "The results combined with the safety measurement of cardiac death, target vessel MI and late stent thrombosis favor the Supreme HT, supporting the early endothelial healing concept."

Contemporary DES have emphasized delay healing through prolonged drug delivery to suppress the body's response to injury, hypersensitivity, or progression of disease. The Supreme HT development was based on the "wound-healing window" concept originally proposed in 2013 and represents a novel class of DES that highlight the importance of early, timely healing. Through patented designs and proprietary processes, the Supreme HT was tailored to help patients accelerate their wound-healing process and restore their natural endothelial function. This healing-targeted mechanism may help overcome the long-standing problem of tradition-DES implantation, allowing for safer long-term results.

"We are very grateful to the extraordinary group of medical professionals and all the patients who have endured through this difficult pandemic and completed this study milestone in such a timely and professional manor," saidJianhua Sun, PhD., Chairman & Chief Executive Officer of SINOMED."The results have been extremely encouraging and if we reach superiority in the landmark analysis, wecould revolutionize the understanding of healing and the future of implantable devices,"

More information on the PIONEER III study is available at http://www.clinicaltrials.gov, identifier: NCT03168776.

About SINOMED

Sino Medical Science Technology Inc. (SINOMED), a global medical device company engaged in research, development, production, and commercial distribution of interventional devices. We are focused on developing breakthrough technologies to target unmet clinical needs in the interventional treatment of coronary, neurovascular and structural heart disease. Our mission is to expose more patients to the benefits of our medical innovations, increasing patient longevity and quality of life.

For more information, visit: http://www.sinomed.com

SINOMED B.V Cindy Zheng T: +31 10 307 6295 E: [emailprotected]

Photo - https://mma.prnewswire.com/media/1333951/SINOMED_Stent.jpg Logo - https://mma.prnewswire.com/media/1333950/SINOMED_Logo.jpg

SOURCE SINOMED

http://www.sinomed.com/

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Late-Breaking Study Results of the Supreme HT Healing-Targeted DES Demonstrated Equivalent Outcomes with Exceptional Safety - PRNewswire

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Late-Breaking Study Results of the Supreme HT(TM) Healing-Targeted DES Demonstrated Equivalent Outco – PharmiWeb.com

TIANJIN, China, Nov. 17, 2020 /PRNewswire/ -- SINOMED today announced that Prof. Alexandra Lansky from the Yale School of Medicine, USA, presented data from its first inter-continental PIONEER III study comparing the safety and efficacy of the Supreme HT (Healing-Targeted) Drug-Eluting Stent, to the Xience or Promus Durable Polymer Drug-Eluting Stent (DP DES). One-year results, revealed at the 2020 American Heart Association Scientific Late-Breaking Trials Session, showed equivalent clinical performance of the Supreme HT to the market-leading DES and will be used to support U.S. Food and Drug Administration and Japanese regulatory approvals.

The PIONEER III study enrolled 1,629 patients (randomized 2:1 experimental to control) from North America, Europe and Japan and had a primary composite endpoint of target lesion failure (TLF) at one-year. The TLF outcomes showed that the Supreme HT met the non-inferiority endpoint at 5.4% compared to 5.1% from the DP DES (p=0.002). A grouped analysis of secondary endpoints showed a numerically better result for Supreme HT in cardiac death or target-vessel myocardial infarction (TV MI) with 3.5% in the Supreme HT arm compared to 4.6% in the control arm (p=0.27). Lower late stent thrombosis data (Supreme HT 0.1% compared to DP DES 0.4%, p=0.22) also suggested exceptional safety for the HT DES. A powered, landmark TLF analysis evaluating the healing superiority of Supreme HT between 1 and 5 years is ongoing.

"I am very pleased that Japanese patients will benefit from the most advanced DES in the US, Europe and Japan," said Shigeru Saito, MD, Shonan Kamakura General, Japan and primary investigator of the Japanese cohort of the PIONEER III study . "The results combined with the safety measurement of cardiac death, target vessel MI and late stent thrombosis favor the Supreme HT, supporting the early endothelial healing concept."

Contemporary DES have emphasized delay healing through prolonged drug delivery to suppress the body's response to injury, hypersensitivity, or progression of disease. The Supreme HT development was based on the "wound-healing window" concept originally proposed in 2013 and represents a novel class of DES that highlight the importance of early, timely healing. Through patented designs and proprietary processes, the Supreme HT was tailored to help patients accelerate their wound-healing process and restore their natural endothelial function. This healing-targeted mechanism may help overcome the long-standing problem of tradition-DES implantation, allowing for safer long-term results.

"We are very grateful to the extraordinary group of medical professionals and all the patients who have endured through this difficult pandemic and completed this study milestone in such a timely and professional manor," saidJianhua Sun, PhD., Chairman & Chief Executive Officer of SINOMED."The results have been extremely encouraging and if we reach superiority in the landmark analysis, wecould revolutionize the understanding of healing and the future of implantable devices,"

More information on the PIONEER III study is available at http://www.clinicaltrials.gov, identifier: NCT03168776.

About SINOMED

Sino Medical Science Technology Inc. (SINOMED), a global medical device company engaged in research, development, production, and commercial distribution of interventional devices. We are focused on developing breakthrough technologies to target unmet clinical needs in the interventional treatment of coronary, neurovascular and structural heart disease. Our mission is to expose more patients to the benefits of our medical innovations, increasing patient longevity and quality of life.

For more information, visit: http://www.sinomed.com

SINOMED B.V Cindy Zheng T: +31 10 307 6295 E: cindy.zheng@sinomed.com

Photo - https://mma.prnewswire.com/media/1333951/SINOMED_Stent.jpg Logo - https://mma.prnewswire.com/media/1333950/SINOMED_Logo.jpg

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Late-Breaking Study Results of the Supreme HT(TM) Healing-Targeted DES Demonstrated Equivalent Outco - PharmiWeb.com

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