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Category Archives: David Sinclair
Scientists recently made some impressive developments in the field of age-related diseases. Nonetheless, essentially turning back time on a living creature's DNA remains indefinable and a "Holy Grail."
It is common knowledge that DNA is gradually breaking down as a person gets older. It is seen that such impairment is aging, and various age-related diseases tend to pop up the older an individual gets.
Harvard Medical Schoolresearchers now seem to have a big leap in moving aging backward in mice. More particularly, the scientists managed to invigorate an aging mice's vision by giving them a boost through the use of genes present during early development.
As the scientists explain in a new study Nature published, the work focused on "glaucoma-induced vision impairment in the mice."
(Photo : analogicus on Pixabay)Research findings recently proposed an approach thats safe and could potentially revolutionize the therapeutics of the eye.
The research team used a virus to impact the mice's retinas through the use of a "trio" of what are described as "youth-invigorating genes."
Such genes: Oct4, Sox2, and Klf4, according to the study, are said to be active when the mice's embryos are developing. This, the study authors said, resulted in an intense reversal of the age-related vision problems experienced by mice.
It stimulated the regeneration of nerve while reversing, too, the glaucoma-like occurrences in the animals plagued by it.
With vision loss minus glaucoma that's related to age, the impact was the same, the study specified. More so, the mice regained their previously lost vision.
According to the study's senior author David Sinclair, their research "demonstrates that it is possible to safely reverse the age of complex tissue" like the retina and has its youthful biological role restored."
If confirmed through further research, such results could be transformative for the care of age-associated vision illnesses such as glaucoma and to the areas of biology and medical treatments for illness at large.
As impressive as their study findings were, warn the study authors that they would need to be duplicated in later studies if further development is to be made through the use of such genes for the reversal of loss of vision in other animals and even humans.
A related article BGRposted said this study may be promising, although it is certainly "not ready for human testing yet."
In connection to this new finding, Yuacheng Lu, an HMS research fellow and former ex-doctoral student in Sinclair's lab, developed a gene treatment that could safely reverse the cells' age in living animals.
The work of Lu's develops on Shinya Yamanaka's Nobel Prize-winningdiscovery. Yamanaka discovered the four transcription factors, namely, Oct4, Sox2, Klf4, c-Myc, that could remove epigenetics markers on cells and bring back these cells to their original embryonic state from which they can progress into any cell type.
At this project's onset, Lu explained, many of their colleagues said their approach would not succeed, or it would be dangerous to use it.
The former doctoral student added, their research findings propose this approach "is safe and could potentially revolutionize the therapeutics of the eye," as well as the many other organs impacted by aging.
ALSO READ: How Good Are You at Recognizing Faces? Here's a New Face Test Scientists Want You To Try
Check out more news and information on Agingin Science Times.
David Grant Sinclair is on trial in the High Court at Greymouth for the murder of his 10-month-old son.
A Hokitika baby died with 30 bruises all over his body, fractures to his skull and bleeding on the brain and behind both eyes.
The Crown says the fatal injuries were inflicted by his father but his father alleges they were sustained from a fall down the stairs.
David Grant Sinclair is charged with murdering his 10-month-old son, CJ Bodhi White, at Hokitika on July 9, 2019.
A jury trial began on Monday in the High Court at Greymouth before Justice Rebecca Edwards. It is set down for two weeks and 27 witnesses plus Sinclair himself are due to give evidence.
READ MORE:* Suppression lifts on Hokitika man charged with murdering 10-month-old son* West Coast baby allegedly killed by father was 'an angel to us', mother says* Homicide investigation launched in Northland after death of baby
CJ Bodhi White died aged 10 months in Hokitika on July 9, 2019. His father, David Grant Sinclair, denies murdering the infant.
Crown prosecutor William Taffs said CJ had been in Sinclairs fulltime care for only six weeks before his death.
He said Sinclair told his family, first responders and police he fell asleep with CJ in his bed and was woken between 3am and 4am by a thud from CJ falling out of bed.
Taffs told the jury CJ had not been sleeping well because he was teething and would have been in significant pain from injuries inflicted earlier by his father, including a fractured bone in his foot and bruising to his groin and scrotum.
He said Sinclair put his phone into incognito mode at 3.27am and searched: Does a babys head flop backwards from concussion.
He then accessed several apps including a gambling site and checked the weather forecast.
At 4.17am, he again searched: Why has my 1-year-olds neck gone all floppy after falling out of bed?
He then sent a message to his mother asking her to call him.
When she rang, he told her CJ had fallen out of bed. She arrived at the house less than 10 minutes later, began CPR and rang emergency services.
CJ was unresponsive and was flown to Christchurch Hospital but doctors ruled out surgery because his injuries were unsurvivable. His life support was turned off at 11.40am. He was declared dead 25 minutes later.
CJ had 30 bruises across his body, significant brain injuries, skull fractures, soft swelling to his skull, bleeding to both retinas and swelling, cuts, bleeding and clots on his brain.
Several medical professionals would give evidence that the injuries were not consistent with a fall out of bed on to a carpeted floor. They were consistent with his father hitting his head against a hard object or hitting his head with a hard object, Taffs said.
He had too many bruises in all the wrong places to be accidental. Bruises consistent with finger marks ... inflicted in what the Crown says was a moment of anger or frustration.
Taffs said Sinclair had told medical professionals the historic bruises were caused when he caught CJs leg in the car seat buckle and from CJ hitting himself with a rattle.
Defence lawyer Andrew McKenzie said the jury would be presented with two vastly different scenarios.
He said Sinclair would give evidence that CJ had fallen down the stairs. The defence would also present evidence from experts.
David Sinclair is guilty of taking too much time to call 111. He is guilty of lying to police and lying to people about his baby falling out of bed. He is guilty of not taking steps to remove the risk of his baby falling down the stairs.
He is not guilty of the crime of murder, McKenzie said.
The jury trial is set down for two weeks and 27 prosecution witnesses will be called to give evidence.
In one way or another, we are all concerned about how well we are aging, whether that is physically, mentally, or visually in the way we look! Living a healthier lifestyle is something many of us focus on as we age; we all want to live well and experience the most out of life! If you have been looking into ways to improve your overall health and promote healthy aging, you may have heard of metformin. Metformin is becoming an increasingly popular topic when it comes to anti-aging, thanks to the several studies that have been published about the incredible benefits for overall health, mortality, and anti-aging. Metformin is derived from natural compounds in the French Lilac plant and has been used to treat diabetes since the Middle Ages. Used for over 60 years, this medication has an outstanding safety record, and is a safe and cost effective.
Leading Harvard scientist, Dr. David Sinclair, wrote a blog on the benefits of metformin anti aging, titled This cheap pill might help you live a longer, healthier life. Dr. Sinclair outlined numerous studies that proved the beneficial effects metformin can have, and we have compiled 6 of the top benefits backed by science.
As we age, we are more likely to face complicated health challenges, like cancer. However, research has shown metformin to have anti-cancer properties that reduce the likelihood of being diagnosed with numerous forms of cancer. In 2009, a promising study was carried out in the UK, with over 62,000 participants. The study revealed that using metformin was associated with a lowered risk of cancer in the colon and pancreas. The study divided participants into four separate groups, based on where they were receiving monotherapy with metformin, or sulfonylurea, combined therapy (metformin plus sulfonylurea), or insulin. Those using metformin monotherapy had the lowest risk of colon and pancreas cancer. Whereas those on insulin, or insulin secretagogues were more likely to develop cancers.
Additionally, a study conducted by the Mayo Clinic revealed that diabetic women who took metformin had a better survival rate than those who did not. This research is extremely significant because ovarian cancer is the 5th most common cancer in women and has a mortality rate of 65%. The benefits of metformin are impressive and women around the world are taking note.
When taking a closer look at the overall mortality rate of cancer patients with Diabetes, a study of 1,300 participants in the Netherlands revealed that metformin use was associated with lower cancer mortality compared with non-users.
Further, metformin users with diabetes were shown to have a reduced risk of colorectal cancer than non-users. A comprehensive study that took place in the United States, included over 460,000 participants over the course of several years. The results revealed an 8% reduction in the likelihood of a colorectal cancer diagnosis among those who used metformin.
Scientists compared 78,000 people diagnosed with type 2 diabetes and compared them to a control group of 78,000 people without diabetic controls. Patients with type 2 diabetes who were taking metformin had a longer survival rate than the non-diabetic control group, over a 5-year period. There have been multiple studies on the use of metformin that confirm the positive effects on overall health and longevity.
In a comprehensive, multi-year study, metformin was shown to reduce the risk of developing diabetes by 31%. This study showed the effect of metformin was equally effective for both men and women. As we see the rates of diabetes on the rise, and the associated health issues related to diabetes can be serious and life-threatening, these results were very positive and have significant potential for those at risk of developing diabetes.
A 2009 study of 390 patients in a randomized, placebo-controlled trial showed that metformin reduced the risk of macrovascular disease. This study included a 4.3-year follow-up period and demonstrated that metformin can significantly reduce cardiovascular mortality. Additionally, the study showed that metformin can reduce the incidence of cardiovascular events in both diabetic, and non-diabetic patients with coronary heart disease. As such, the benefits of metformin are effective for anti-aging purposes, due to the fact cardiovascular health typically declines with age.
A study of 67,731 participants who were non-demented, non-diabetic, and over 65 years of age, were studied from January 2004 to December 2009: The study revealed that diabetes is associated with an increased risk of dementia. When provided with sulfonylureas or metformin, rather than thiazolidinediones for a longer period the risk was reduced. More specifically, the study determined that metformin use showed a significant inverse association with cognitive impairment. This large scale study controlled for age, education, diabetes duration, fasting blood glucose, vascular and non-vascular risk factors. This is a significant finding proving the anti-aging effects of metformin.
Weight-loss is something on many peoples minds as they age, and not just for superficial reasons! Weight gain can affect mobility, can negatively impact cardiovascular health, and can result in a wide array of other health challenges. As we age, it often becomes more difficult to lose weight. A 2012 study of 154 patients was conducted over a 6 month period in Germany. The purpose of the study was to determine the efficacy of metformin for the treatment of obesity. The results were impressive and demonstrated that metformin is an effective drug to reduce weight in a naturalistic outpatient setting in insulin sensitive and insulin resistant overweight and obese patients.
The anti-aging benefits of metformin have been experienced by thousands of patients around the world. Not only can it reduce mortality, but it can improve longevity, overall health, and quality of life as one ages. The studies on metformin have been extensive, and the results truly do speak for themselves. In addition to the listed benefits of above, studies have shown metformin slows down the rate of DNA damage. Though access to metformin has not always been easy, there are telehealth subscription services available that have improved access to buy metformin. AgelessRx.com is an American based company that provides high-quality metformin through their telehealth subscription service.
In the hours after Pfizers momentous vaccine news emerged on Monday #pfizerproud popped up on my social media feeds again and again from the firms employees, both past and present.
Ive been an avid observer of pharma social media for some time and this is somewhat unusual. Not for the pharma employees to be proud of the work they do, but such a spontaneous and widespread demonstration of pride in our industry is not normally seen, though it is thoroughly deserved here.
Interim analysis of the COVID-19 vaccine candidate Pfizer has been working on with BioNTech found it to be more than 90% effective at countering the disease, and the company said it expected to be in a position to file BNT162b2 for FDA approval in the third week of November.
The phase 3 trial results are a huge advance in the fight against the global coronavirus pandemic. The study, which only began at the end of July, has enrolled 43,538 patients to date and has shown that protection against COVID-19 is achieved 28 days after the initiation of the two-dose vaccination.
As Pfizers CEO Albert Bourla said: Today is a great day for science and humanity. We are a significant step closer to providing people around the world with a much-needed breakthrough to help bring an end to this global health crisis.
The work to date certainly justifies Bourlas insistence on pushing his vaccine research and manufacturing leadership to think differently about the issue and move quicker that they would have thought possible.
The scientists have done their job
Think in different terms, he told them back in March, according to Forbes, when the COVID-19 pandemic was beginning to overwhelm countries like Italy and Spain in Western Europe.
Think you have an open chequebook, you dont need to worry about such things. Think that we will do things in parallel, not sequential. Think you need to build manufacturing of a vaccine before you know whats working. If it doesnt, let me worry about it and we will write it off and throw it out.
His approach is certainly in keeping with the transformative nature of 2020 and the innovations and adaptations that the year has so far forced on us all. It was, after all, shortly after the outbreak began in January that scientists from China published details of the SARS-CoV-2 virus.
Of course, the Pfizer/BioNTech COVID-19 vaccine is just one of many in development and study is still ongoing and collecting additional safety and efficacy data.
Its final vaccine efficacy percentage may vary from the headline grabbing results released this week, as the companies themselves have noted, and many wider questions remain for policymakers and politicians. Theres the ongoing issue of public attitudes to vaccines and trust, deliberations on how to best distribute Pfizers, or any other companys, COVID-19 vaccine, and the financial returns of any vaccines will be sure to be scrutinised.
Having a vaccine which works is just the starting point, acknowledged David Sinclair, director of UK charity and thinktank the International Longevity Centre commented. But he added: That we are one step closer to a vaccine against Covid-19 is brilliant news. The scientists have done their job.
Its a sentiment that can be applied to all of those across the industry who have been working, directly or indirectly, on COVID-19 and all the healthcare outcomes affected by the pandemic.
So, although I started this article focusing on #pfizerproud, the industry should also be #gileadproud, #astrazenecaproud, #lillyproud and so on.
Hope from medicines, vaccines and health tech
Pharma has always existed at close intersection to mainstream society. Its an industry that touches all of our lives with its vital role in our healthcare, but this year has, unfortunately, given it even more resonance.
At a time when the public is obsessing over infection rates, the R number and COVID-19s deadly toll, like many in the industry Ive been having really quite detailed conversations with non-pharma friends about clinical trials, vaccines and public health.
The upshot of those conversations, in addition to a burning desire for rapid progress, is that we need pharma now more than ever.
As ABPI chief executive Richard Torbett said earlier this week when talking about the importance of vaccines: Millions of people all over the world are living under some form of restrictions.The organisations who research, develop and manufacture medicines, vaccines and health tech are our best hope of treating, preventing or one day even eradicating the virus.
Much as Joe Bidens win in the US presidential election provides a sense of a weight having been lifted from the minds of many, in the US and far around the world, Pfizers COVID-19 vaccine clinical trial results brings a similar sense of relief.
In neither case are we out of the woods yet, and its not even that things wont get worse before they get better but the last week has provided some very welcome news indeed.
So, for now, lets celebrate a major step towards the emergence of a COVID-19 vaccine and be #pharmaproud about the huge contribution the industry had made, and is making, during this global health emergency.
About the author
Dominic Tyer is a journalist and editor specialising in the pharmaceutical and healthcare industries. He is currently pharmaphorums interim managing editor and is also creative and editorial director at the companys specialist healthcare content consultancy pharmaphorum connect.
Connect with Dominic on LinkedIn or Twitter
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We should allow ourselves to be #pharmaproud - - pharmaphorum
We recently came across this article on Mind BodyGreen that was written by their senior health editor, Kristine Thomason, that we thought was well worth the share as it ties in with similar articles that we have published.
By now, you're very familiar with the daily COVID-prevention checklist: Wash your hands, don't touch your face, wear your mask in public, and socially distance from others. And repeat. Each of these precautions aligns with guidelines the Centers for Disease Control and Prevention (CDC) released early on in the COVID-19 pandemic, to help mitigate viral transmission.
What the CDC (or any of the powers that be, for that matter) doesn't address quite so clearlymuch to many experts' dismayis the fact that nutrition is also a non-negotiable in the fight against COVID-19.
As for the CDC guidelines, there is a mention tucked into their "Food and Coronavirus" guidelines, where they advise: Reduce pandemic-related stress through good nutrition; incorporate vitamins C and D, plus zinc, into your diet for possible immune system support; read labels on any canned foods you buy, and seek out the healthiest options; and prioritize fruits, vegetables, lean protein, and whole grains. They also point toward resources at the USDA Nutrition Assistance Program if you need help securing nutritious foods.
Of course, all that information is important and usefulas are the other COVID-19 guidelines the CDC has laid out. But, unfortunately, there's not a single mention of nutrition as a preventive measureit's entirely left out of the conversation on their "Prevent Getting Sick" section. The way we see it, leaving nutrition as a side note is a huge miss. After all, we've had nutrition top of mind since day one of the pandemicwhether it's featuring an immunologist's COVID dietary advice or discussing top immune-supporting nutrients with a longevity expert.
One expert who has been particularly outspoken about this topic is preventive medicine specialist David Katz, M.D. He already gave a compelling COVID reality check on the mindbodygreen podcast, and now, he's sharing his thoughts on the importance of nutrition as a tool to keep you healthynow and always. But especially now.
Why nutrition needs to be a priority, not an afterthought.
"The greatest single influence of whether you develop a bad chronic disease or die prematurely is your diet quality," says Katz. "Diet is constantly, universally important. Literature showing that it is the single leading predictor of all-cause mortality is incontrovertible."
So, why exactly don't we hear more about diet in relation to disease prevention? To start, other factors that affect health and mortality are often much more straightforward. For example: You're either a smoker or a nonsmoker; you either do physical activity or you don't; your blood pressure is either high or normal. "But diet is an infinite array of intermingled variables," says Katz. "There are many ways to get it right. There are many more ways to get it wrong."
There are also numerous other factors at play (think cultural, socioeconomic, the list goes on) that can interfere with your access and understanding of optimal nutrition. Not to mention, as survival-driven humans, our instincts are programmed to be more attuned to immediate threats rather than long-term ones, Katz explains. "One of the reasons we neglect our diet is it doesn't fly at the speed of a bullet," he says. "If I eat a doughnut today, it won't affect me tomorrow. The cause and effect are separated by time, so it's hard to see. We are pretty blas about the massive association between diet and adverse health outcomes in general." That is, until we're faced with a pressing threat. Enter: COVID-19.
Why focusing on diet amid COVID-19 is both a necessity and an opportunity.
It's no secret that individuals with underlying health conditions like heart disease, asthma, diabetes, and chronic lung disease are at a higher risk of adverse COVID outcomes. "To ignore that is absurd, and to ignore that diet is the greatest single driver of all of that is also absurd," says Katz.
For that reason, Katz sees the current COVID-19 climate not only as a reason to prioritize diet more than ever but also an ideal time for people to make lasting change.
"It's a massive opportunity to address the acute and the chronic," he says. "We should have done it anyway, but that's the problem with dietit's a slow-motion threat; it doesn't trigger our anxiety. COVID does, so I say, let's catch the wave."
So, what can you do...today?
"There's never been a better time to have the 'let's get healthy, America' conversation," says Katz. That's because, even small, conscious changes can affect your health and immunity.
As for a healthy diet, Katz believes there's a basic theme to eating optimally, but there isn't a narrow prescription every person needs to adopt. To get you started on your own path, he shares a few tips for taking positive, dietary steps forwardand they're backed by other experts in the field, too:
1. Start with one healthy meal...but know the benefits get better over time.
"You can alter your immune response with a single meal," Katz says, "the magnitude of benefit will accrue over time, you certainly won't get the full measure from one good meal, but you can start the party." He notes that there is evidence in studies that observe how harvest cells in the immune system react to different stimuli. "They react in a way that's more likely to protect you following a high-quality meal, as opposed to a low-quality meal."
2. Opt for wholesome, natural foods.
"Essentially the closer you get to foods that come directly from nature, the better," says Katz. "So you want to avoid ultra-processed stuff and eat as much real, minimally or unprocessed foods as possible." Simple steps in the right direction might mean sipping water instead of soda or choosing whole grains instead of refined ones. "And if the ingredient list runs off the box, it's probably a bad idea."
And when it comes to choosing those foods...amid a pandemic, experts and the CDC agree that foods rich in vitamin C, vitamin D, and zinc may be particularly beneficial. "There's no disagreement between scientists and doctors that vitamin D is important for the immune system," David Sinclair, Ph.D., said during a recent mbg podcast episode. While Amy Shah, M.D., notes that vitamin C is such an important nutrient for immune support.
Supplements are also an option, but Katz points out these should be used as "supplemental to, not substitutes for a high-quality diet."
3. Swap in plants when you can.
"Since our diets tend to be heavy on animal foods, and most people consume too few fruits and vegetables, the more you can shift to plant foods the better," says Katz. That includes an array of fruits, veggies, whole grains, beans, lentils, nuts, and seeds. "Basically, any time you can eat a plant instead of an animal, do."
Other experts agree with this sentiment, including Jeffrey Bland, Ph.D. "If we go back to the cultures that have respected longevity and ask what they ate, we find that they're eating very hearty plants," he shared in a recent mbg podcast episode.
Of course, there are other measures you can takebut a healthy diet doesn't need to be overly complex, by any means. As Katz puts it, "It's just that simple; it's just that powerful. It's actionable, it's immediate, and there's never been a better time."
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Why Aren't We Talking More About Nutrition Amid COVID-19? - Anti Aging News
Boss Ricky Waddell believes the pressure has eased on his Caledonian Braves stars after their first win of the Lowland League season.
Jack Smith, David Winters and David Sinclair earned The Braves the three points against Dalbeattie Star, with Steven Degnan's strike for the visitors proving to be a consolation for the hosts.
With a huge clash with current league champions Kelty Hearts this weekend, Waddell believes it was crucial to get off the mark last night after an impressive display.
He told Lanarkshire Live Sport : "We really set the tone of the game early on that was important for us.
"We had a couple of sticky moments but I felt we were comfortable at half-time going in at 2-0.
"We didn't give away many chances and rode the storm after they got their goal before David's free-kick wraps things up for us.
Gallery: Predicted XI: Celtic v Rangers (H) (Read Sport)
"It gives us a bit of breathing space after a tough start to the season.
"We are getting bodies back, hopefully, in time for Saturday and we are getting back to where we were before the injuries in pre-season.
"If we go into Kelty off the back of four defeats you are starting to think it's going to be a tough task.
"I feel the boys can breathe a bit easier. Dalbeattie Star is a dangerous game, they take points off people and always come with a plan.
"The win takes away the thought that it has been a really bad start to the season.
"What has happened is that we have improved every game and it gives the players and myself a bit of a lift going into the Kelty game.
"I've been at clubs where you're struggling for a win and that becomes a habit. That's broken right away for us and we can concentrate on progressing."
Follow Lanarkshire Live Sport on Twitter via @LanLiveSport, like us on Facebook or find us on Instagram for the latest sports news, pictures and video.
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Caledonian Braves can 'breathe a bit easier' after first win says boss Ricky Waddell - MSN UK