Category Archives: David Sinclair

Its been 13 years in the making, but Dr. David Sinclair and his colleagues have finally answered the question of what drives aging. In a study published Jan. 12 in Cell, Sinclair, a professor of genetics and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, describes a groundbreaking aging clock that can speed up or reverse the aging of cells.

Scientists studying aging have debated what drives the process of senescence in cellsand primarily focused on mutations in DNA that can, over time, mess up a cells normal operations and trigger the process of cell death. But that theory wasnt supported by the fact that older peoples cells often were not riddled with mutations, and that animals or people harboring a higher burden of mutated cells dont seem to age prematurely.

Sinclair therefore focused on another part of the genome, called the epigenome. Since all cells have the same DNA blueprint, the epigenome is what makes skin cells turn into skin cells and brain cells into brain cells. It does this by providing different instructions to different cells for which genes to turn on, and which to keep silent. Epigenetics is similar to the instructions dressmakers rely on from patterns to create shirts, pants, or jackets. The starting fabric is the same, but the pattern determines what shape and function the final article of clothing takes. With cells, the epigenetic instructions lead to cells with different physical structures and functions in a process called differentiation.

In the Cell paper, Sinclair and his team report that not only can they age mice on an accelerated timeline, but they can also reverse the effects of that aging and restore some of the biological signs of youthfulness to the animals. That reversibility makes a strong case for the fact that the main drivers of aging arent mutations to the DNA, but miscues in the epigenetic instructions that somehow go awry. Sinclair has long proposed that aging is the result of losing critical instructions that cells need to continue functioning, in what he calls the Information Theory of Aging. Underlying aging is information that is lost in cells, not just the accumulation of damage, he says. Thats a paradigm shift in how to think about aging.

His latest results seem to support that theory. Its similar to the way software programs operate off hardware, but sometimes become corrupt and need a reboot, says Sinclair. If the cause of aging was because a cell became full of mutations, then age reversal would not be possible, he says. But by showing that we can reverse the aging process, that shows that the system is intact, that there is a backup copy and the software needs to be rebooted.

In the mice, he and his team developed a way to reboot cells to restart the backup copy of epigenetic instructions, essentially erasing the corrupted signals that put the cells on the path toward aging. They mimicked the effects of aging on the epigenome by introducing breaks in the DNA of young mice. (Outside of the lab, epigenetic changes can be driven by a number of things, including smoking, exposure to pollution and chemicals.) Once aged in this way, within a matter of weeks Sinclair saw that the mice began to show signs of older ageincluding grey fur, lower body weight despite unaltered diet, reduced activity, and increased frailty.

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The rebooting came in the form of a gene therapy involving three genes that instruct cells to reprogram themselvesin the case of the mice, the instructions guided the cells to restart the epigenetic changes that defined their identity as, for example, kidney and skin cells, two cell types that are prone to the effects of aging. These genes came from the suite of so-called Yamanaka stem cells factorsa set of four genes that Nobel scientist Shinya Yamanaka in 2006 discovered can turn back the clock on adult cells to their embryonic, stem cell state so they can start their development, or differentiation process, all over again. Sinclair didnt want to completely erase the cells epigenetic history, just reboot it enough to reset the epigenetic instructions. Using three of the four factors turned back the clock about 57%, enough to make the mice youthful again.

Were not making stem cells, but turning back the clock so they can regain their identity, says Sinclair. Ive been really surprised by how universally it works. We havent found a cell type yet that we cant age forward and backward.

Rejuvenating cells in mice is one thing, but will the process work in humans? Thats Sinclairs next step, and his team is already testing the system in non-human primates. The researchers are attaching a biological switch that would allow them to turn the clock on and off by tying the activation of the reprogramming genes to an antibiotic, doxycycline. Giving the animals doxycycline would start reversing the clock, and stopping the drug would halt the process. Sinclair is currently lab-testing the system with human neurons, skin, and fibroblast cells, which contribute to connective tissue.

In 2020, Sinclair reported that in mice, the process restored vision in older animals; the current results show that the system can apply to not just one tissue or organ, but the entire animal. He anticipates eye diseases will be the first condition used to test this aging reversal in people, since the gene therapy can be injected directly into the eye area.

We think of the processes behind aging, and diseases related to aging, as irreversible, says Sinclair. In the case of the eye, there is the misconception that you need to regrow new nerves. But in some cases the existing cells are just not functioning, so if you reboot them, they are fine. Its a new way to think about medicine.

That could mean that a host of diseasesincluding chronic conditions such as heart disease and even neurodegenerative disorders like Alzheimerscould be treated in large part by reversing the aging process that leads to them. Even before that happens, the process could be an important new tool for researchers studying these diseases. In most cases, scientists rely on young animals or tissues to model diseases of aging, which doesnt always faithfully reproduce the condition of aging. The new system makes the mice very old rapidly, so we can, for example, make human brain tissue the equivalent of what you would find in a 70 year old and use those in the mouse model to study Alzheimers disease that way, Sinclair says.

Beyond that, the implications of being able to age and rejuvenate tissues, organs, or even entire animals or people are mind-bending. Sinclair has rejuvenated the eye nerves multiple times, which raises the more existential question for bioethicists and society of considering what it would mean to continually rewind the clock on aging.

This study is just the first step in redefining what it means to age, and Sinclair is the first to acknowledge that it raises more questions than answers. We dont understand how rejuvenation really works, but we know it works, he says. We can use it to rejuvenate parts of the body and hopefully make medicines that will be revolutionary. Now, when I see an older person, I dont look at them as old, I just look at them as someone whose system needs to be rebooted. Its no longer a question of if rejuvenation is possible, but a question of when.

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Scientist Discovers Aging Clock to Speed and Reverse Aging | Time

New Delhi,UPDATED: Mar 18, 2023 15:53 IST

Dr David Sinclair speaking at the India Today Conclave 2023 in Delhi. (Photo: India Today)

By India Today Science Desk: There is a backup of youth in our cells that we have recently learned about that can be made to work, Dr David Sinclair, Professor in the Department of Genetics at Harvard Medical School said. He added that the technology to reverse aging and trigger bio switches is developing faster than we expected.

"The science of aging and reversal has come a long way. It was considered crazy 20 years ago, but today we understand what drives aging and there is a backup of youth in our cells that we have recently learned that can be made to work. Technology is developing faster," Dr Sinclair added.

David Sinclair was speaking at the India Today Conclave 2023 in Delhi. He discussed the science of age and disease reversal as more and more research pours into understanding the process of aging. The 53-year-old genetics professor, who is also an anti-aging researcher, was recently in the news as he claimed his biological age is 10 years younger.

"What we discovered is that there are genes that control how long we live. Some people are born with the best version of those genes who tend to live for 100 years and what we have discovered is how we live our lives, move and consume, sleep, and how relaxed we are modifies another type of system known as epigenomes," Dr. Sinclair said.

Known for his work on understanding why we age and how to slow its effects, Dr. Sinclair said that the good news is that aging is easier to slow and reverse than we thought. The bad news is that the process gives our bodies a shock.

Speaking about the diet he takes to slow the process, the genetics professor said that there is a set of genes that get turned on when there is not enough energy, like low sugar and protein, and they defend the body against the damage that causes the aging process.

"I skip meals at times, but my goal is to not eat a large meal until dinner and then have a healthy vegan meal and little alcohol. I switched completely to planets and my body has responded well, my skin looks better, my memory is better. The three-meal system plus snacks is aging us faster than we need to," Dr. Sinclair said.

Talking about plant-based meals that he switched from meat and alcohol to slow his aging process, Dr. Sinclair said that "The proteins that are in plants have a ratio of amino acids that stimulate longevity genes, and if you eat meat every meal the body does not fight the way plants help it do."

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There is a backup of our youth in cells that can be reversed: David ...

Whats the secret to looking and feeling younger? For some, its expensive surgeries. For others, its a change in health and wellness habits. But what does science say?

David Sinclair, a 53-year-old genetics professor and anti-aging researcher who claims his biological age is 10 years younger, swears by four key habits:

While these habits can certainly contribute to a healthy lifestyle overall, experts disagree about their link to longevity. For example, research is mixed on whether intermittent fasting can slow the aging process. But Sinclair, who is also the cofounder of Tally Health, a membership-based longevity platform that includes TallyAge testing, an at-home test to determine your biological age, says his habits have dramatically altered his life span.

My calculated biological age has been going down for the past decade or more to a point where Im predicted to live at least a decade longer than I would have if I hadnt done anything, Sinclair said in a recent interview with Insider. So its never too late.

In addition to a plant-based diet and cutting back on alcohol, Sinclair shared that he drinks one to two matcha teas per day and takes supplements that contain resveratrol, an anti-inflammatory compound most commonly found in red wine. But the jury is out on whether people can reap the same benefits in a pill form.

As soon as I see resveratrol in anybodys supplement stack, they lose all credibility, University of Washington longevity researcher Matt Kaeberlein told Insider. Its been disproven over and over and over in the longevity field, at least.

Sinclair, however, maintains that these habits arent just about living longer, but making the most of healthy years.

Nobody wants to be sick for a decade or have cancer that drags on or be frail, he told Insider. What were really talking about is preventing those things, or squeezing them into the last bit of life.

Link:
Four habits to reduce your biological age | Fortune Well

Dr. David Sinclair is a world-renowned longevity scientist best known for his research on resveratrol and the sirtuin genes of yeast. He has also been recognized by TIME magazine as one of the top 100 most influential people globally and is an Adjunct Professor of genetics at Harvard Medical School.

Besides supplementing with groundbreaking anti-aging drugs such as NMNand resveratrol, David follows a strict diet and exercise routine.

Dr. Sinclairs work on aging has profoundly impacted our understanding of how aging works and what it means to be old- and, more importantly, how we can live longer, healthier lives without radical life extension technologies. Here are sixteen Dr. Davids recommendations on diet and exercise from his book Lifespan: Why We Age and Why We Dont Have To.

Dr. David Sinclair is a firm believer in restricting caloric intake to extend life expectancy. However, he doesnt fully subscribe to the belief that calorie restriction can dramatically prolong human longevity. Calorie restriction has been shown to work in every animal except humans, says Dr. Sinclair, who believes that reducing daily caloric intake by 30 percent should result in increased longevity.

Although Dr. Sinclair says there is no way of knowing for sure if 30 percent is the optimal caloric intake level, he also points out that there are now literally hundreds of experiments in animals showing lifespan extension by calorie restriction.

RELATED READING: Dr. David Sinclairs Supplement List for Longevity

Theres a lot of evidence that exercise extends lifespan. You can probably extend the life of mice by doing wheel running, but its not for another ten years-its maybe 5 percent longer.

Dr. Sinclair should know, he conducted many of the first studies showing the health benefits of caloric restriction in yeast and its effects on human cells growing in lab dishes; later, these experiments led to clinical trials in humans. In fact, Dr. Sinclair is a proponent of exercise and includes walking as part of his daily regimen. I limit calories greatly, but I do exercise every day, he says.

RELATED READING: Dr. Peter Attias Supplement List, Biohacking Toolkit, & Diet

We all have a certain percentage of fat in our body, and we also have some sugar thats stored in the liver. In human experiments, after fasting overnight, people get about half their energy from burning sugar and half from burning fat. So every day when youre fasting, says Dr. Sinclair, you use up part of your sugar and part of your fat. Every time you eat, you replenish the sugar, so its always half full-its about 50 percent full every day.

RELATED READING: Dr. David Sinclairs NMN & Resveratrol Protocol

David believes that constant snacking is not the best way to prolong life expectancy. Im big on intermittent fasting and restricting calories, and I think people should not snack-its much better to have your three meals a day, says Dr. Sinclair, who also advocates skipping breakfast. When you intermittent fast, you can reduce insulin levels by 40 percent, and that helps improve health in many different ways.

RELATED READING: Tim Ferrisss 3-Day Fasting Protocol

Dr. Sinclair believes that people should use natural supplements instead of prescription drugs because theyre less expensive and more effective. Many prescription drugs are toxic and dangerous, says Dr. Sinclair, who believes that supplements can also play an important role in preventing damage from free radicals and promoting health. Natural supplements can replace prescription drugs-theyre safer and more effective.

Dr. Sinclair is huge advocate for taking Nicotinamide Mononucleotide (NMN) and Resveratrol which made red wine famous for being known for extending your life in small amounts. David has his own supply in his lab that he takes, but fortunately you can pick up NMN and Resveratrol on the Renue By Science website. You can read up on David Sinclairs Supplement Regime here.

RELATED READING: Dr. Andrew Hubermans Time-Restricted Diet

Dr. Sinclair emphasizes that you cant take shortcuts when it comes to planning a diet and exercise regimen-the best way to prolong life expectancy is to eat st healthy balanced diet food, taking care not to overload your body with fructose or simple sugars. Every time you eat fruit, its like eating sugar because the fructose in the fruit turns into glucose very quickly, says Dr. Sinclair, who recommends eating green vegetables and blueberries every day to get the maximum levels of antioxidants in your diet.

Im a big proponent of the view that we seem to be getting more and more people focused on these high-tech anti-aging treatments, says Dr. Sinclair. He believes that vast sums of money spent on life extension research would be better used for other purposes. My biggest regret is that gerontologists have been focusing so much money on a very, very few approaches to anti-aging research, says Dr. Sinclair, who urges people to explore lifestyle choices that have been proven effective in prolonging life. Theres a lot of evidence that caloric restriction works and exercise works.

RELATED READING: Dr. Andrew Hubermans Sleep Cocktail

Dr. David Sinclair believes that exercise should be high-intensity so it can trigger The Epigenetic clock. I dont believe in exercise that is not strenuous, says Dr. Sinclair, who adds that people should try high-intensity interval training three times a week, working out at 85 percent of their maximum heart rate for about two minutes or until they are exhausted. You can get the benefits of exercise in three minutes a day just do sprinting to exhaustion, just push yourself as hard as you possibly can for about 3 minutes and then rest.

Dr. Sinclair believes that when exercising, you should also breathe deeply and rapidly to boost oxygen in the bloodstream and increase caloric burn, which will help activate the Epigenetic clock. Ive been a big proponent of breathing during exercise-breathing every 20 seconds, says Dr. Sinclair, who adds that he stays in good shape by running three miles every morning. Its really changed my life; I have more energy-its great.

RELATED READING: Dr. Andrew Hubermans Supplement List

Cold weather increases your immune system, says Dr. Sinclair, who recommends people get their hands on a cold thermometer and put it in their armpits when they wake up-the colder the reading in 10 minutes, the healthier you are. The less time you will spend with disease symptoms. Theres an evolutionary theory that the reason we like the heat is that it simulates our African origins, where everything was hot and tropical, says Dr. Sinclair. Cold is the future-we evolved as cold-weather animals.

Dr. Sinclair believes that your genetic make-up is not a predictor of your future health. The most important thing about beating aging is to know that the fate of your health is in your hands, says Dr. Sinclair, who believes people can significantly slow down the clock with healthy lifestyle choices. Weve gotten rid of the idea that its just genes against destiny-we know that we can change the genes, and we can change our destiny.

RELATED READING: Tim Ferriss Supplement Stack

Im absolutely against cigarettes, says Dr. Sinclair, who urges people to avoid smoking and all other tobacco products because they contain a potent toxin called formaldehyde, which is used in embalming fluid. People think that cigarettes are safe-cigarettes kill half a million Americans every year, says Dr. Sinclair, who believes the health consequences from smoking are so severe that many people have been driven to drug abuse.

Dr. Sinclair urges people to avoid alcohol as much as possible because of its link to cancer. Alcohol is a major carcinogen, says Dr. Sinclair, who believes that if you drink alcohol, you should limit yourself to one glass of wine per day. Every time people take a drink, they raise their risk of breast cancer and another cancers-its just not worth it, says Dr. Sinclair, who points out that there is strong evidence that alcohol can cause tumors in the mouth and throat.

RELATED READING: Dr. Rhonda Patricks Fish Oil Protocol & Brand

Dr. Sinclair recommends that people avoid heating food in plastic containers because it can cause toxic chemicals to leak into the food and lead to cancer and other disorders. Dont microwave in Styrofoam or plastic, says Dr. Sinclair, who urges people to stop using plastic containers when cooking and instead use glass, which doesnt contain harmful chemicals. Those plastic containers are a real danger-microwaving food in them for as few as five minutes can leach out those toxic compounds into your food.

Dr. Sinclair recommends that people who want to quit smoking should try natural nicotine replacement therapy instead of smoking, which actually increases craving. I think the best way to quit smoking is not to start, says Dr. Sinclair, who believes people should make an effort to stop smoking because cigarette smoke remains in the body for a long time after you finish your last cigarette and can cause cancer even if it has been years since you lit up. The sooner you quit smoking, the better off you are if you quit at age 20; your life expectancy is almost normal.

Dr. Sinclair believes people should make an effort to eat fruits and vegetables every day, either in a smoothie or salad. Youve got to get at least five servings of fruits and veggies every single day, says Dr. Sinclair, who believes that both fruits and vegetables reduce the risk of cancer and other diseases by eliminating free radicals from the body. If you want to live a long life, it all starts with those five servings.

Dr. David A. Sinclair is a famous author, professor, and scientist of international repute known for his research on aging and its control in the body with natural ingredients, which the scientific community has widely recognized. You can pick up his book Lifespan: Why We Age and Why We Dont Have To on Amazon.

Though Dr. David A. Sinclair has received numerous awards, he still works hard towards achieving more scientific breakthroughs and gives lectures to promote awareness about nutrition and dietetics.

He instills a sense of motivation and positivity in the people who seek his advice and help them improve their health and lead a healthier life without getting exposed to harmful chemicals which can cause damage to our body over time.

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Dr. David Sinclairs Diet & Exercise Protocol - Brainflow

David Sinclair and Anti-Aging Supplements

Dr. David Sinclair has revolutionized the way that people view aging. As a scientist and pioneer in genetics and longevity research, hes been listed by TIME as one of the 100 Most Influential People in the World, has received more than 35 awards and honors, and is currently working as a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School.

Sinclair is also the author of a New York Times bestseller, Lifespan: Why We Age And Why We Dont Have To, published in 2019. His book presents scientific research in a way that is understandable and its inspired people of all ages to strive for a longer, healthier life.

In his book, he talks about the history of longevity research, current developments and the future of the field. He shares his unique views on aging, which has people rethinking their own outlook on it.

He believes that aging is a disease, its treatable and that we can treat it within our lifetimes.

According to Sinclair, There is no biological law that says we must age.

Sinclairs work involves focusing on aging as the cause of most diseases, while figuring out how the process can be slowed down and reversed. He states that people have longevity genes, which are built-in defenses against aging.

David Sinclair, along with other prominent longevity experts, takes Metformin, which is a prescription medication commonly used by diabetics. Research shows great potential for other uses. In his recent podcast, Sinclair stated that people on Metformin with diabetes live longer than people without diabetes and not on it, and theyre also protected against diseases. But, for those who arent able to acquire a prescription, or would prefer a natural alternative, Berberine may be a better option. Berberine has studies to show that it may have similar effects. Its been shown to help lower blood sugar and improve cardiovascular health, among other potential benefits.

In his book Lifespan, David Sinclair mentions that he takes 1 gram of NMN. This is an obvious choice because recent research has been pointing towards the benefits of taking NAD+ precursors. NMN is the most stable and most reliable nicotinamide adenine dinucleotide (NAD+) precursor available in the market.

The reason that David Sinclair takes NMN is to improve the NAD+ levels in the body. When we age, the NAD+ available to our cells and tissues steadily declines. The latest research shows that by increasing the NAD+ levels available to our body, we can slow down or even reverse the process of aging.

NMN is found in nature, especially in fruits and vegetables like cucumbers, edamame, cabbage, broccoli, and avocados. However, the amount of NMN is too little for us to replenish the depleting NAD+ reserves of our bodies. Most of our NMN comes from vitamin B3 synthesis. Taking NMN supplements allows us to increase the amount of NMN available to our tissues, thus replenishing the lowering levels of NAD+ with age.

While our understanding of NMN and NAD+ is still evolving, research continues to confirm its role in NAD+ production. It is understood that NMN and NR (another NAD+ precursor) are involved in a cycle where NMN gets converted to NR which then goes into the cell to produce NAD+. Recently, a study has discovered an elusive NMN transporter that delivers NMN inside the cell. Thus, as we understand NMN better, we find it to be increasingly important in NAD+ production and anti-aging.

The second supplement mentioned by David Sinclair in his book Lifespan is Resveratrol. He says that he takes 1 gram of Resveratrol, along with NMN, in the morning (See Figure 3).

Resveratrol belongs to a group called polyphenols and is found in over 70 species of plants, including berries and red grapes. Research has found a lot of anti-aging benefits of Resveratrol including its anti-oxidant

properties , anti-inflammation activity, its role in weight loss and cardiovascular health, and its anti-cancer properties . Thus, there are a variety of reasons to consume Resveratrol supplements.

David Sinclair also takes the prescription drug metformin. The drug is mainly prescribed to individuals with type-2 diabetes. However, metformin has shown remarkable life-extending properties in mammals and many organisms. Diabetics who take metformin end up living longer than non-diabetes who do not take the drug. With so many benefits, it is obvious why David Sinclair decided to take the drug.

However, metformin does not come without its own set of issues. In the short term, metformin is associated with a range of side effects such as gastrointestinal discomfort and diarrhea. These symptoms decrease in a matter of a few weeks. However, metformin is also associated with higher uptake of Vitamin B12 in the longer run. Metformin is also believed to decrease the benefits of exercise. It also lowers endurance and negatively impacts muscle strength.

While David Sinclair stated that he takes metformin, many others are turning to Berberine as a natural non-prescription alternative. Berberine has the ability to mimic the anti-diabetic properties of metformin while perhaps even outperforming it in enhancing longevity and stabilizing blood sugar.

Vitamin D is necessary for a number of functions, including activating many important genes. A vitamin D deficiency increases the risk of many conditions that speed up the process of aging such as type-2 diabetes, Alzheimers diseases, cardiovascular diseases, etc.

As for vitamin K, its benefits are numerous and spread across the body. It is good for mitochondrial and vascular health and also plays a part in improving skin appearance and it works synergistically with Vitamin D.

Sinclair recently said on Twitter that he has been taking Fisetin for over two years. He also cited a study by Yu-Fen Lin and the team, noticing that Fisetin reduces chronic stress in mice.

Fisetin is also credited with removing senescent cells from our bodies. A 2016 study noted the following as benefits of Fisetin: anti-inflammatory, anti-oxidant, anti-tumorigenic, anti-invasive, anti-angiogenic, anti-diabetic, neuroprotective, and cardioprotective effects in cell culture and animal models relevant to human diseases. Sinclair believes that Fisetin is important in fighting to age.

Quercetin is a flavonoid contained in many fruits and vegetables like grapes, apples, broccoli, and tomatoes. Quercetin has many antioxidant and anti-inflammatory properties but recently, David Sinclair has stated that he takes it daily as a senolytic.

Quercetin was recently shown to reduce senescent cells in adipose tissue. In another study, it was shown to have an even stronger effect when combined with the chemotherapy drug, Dasatinib. Other benefits of Quercetin include reduced swelling, destroying cancer cells, controlling blood sugar, and helping to prevent heart disease.

Coenzyme Q10 is a powerful antioxidant that may prevent certain diseases and signs of aging. Specifically, CoQ10 is involved in energy production and can prevent cellular damage associated with aging.

In studies, CoQ10 has been shown to prevent neurogenerative diseases like Parkinsons, Alzheimers, Huntingtons disease, progressive supranuclear palsy, and other forms of dementia. Coenzyme Q10 may help with certain cardiac diseases, including heart failure, atherosclerosis (fatty deposits in the arteries), and coronary artery disease (fatty deposits in the arteries supplying blood to your heart). Sinclair has added CoQ10 to his supplement stack and has mentioned its benefits in several podcasts.

Trimethylglycine (TMG) also referred to as betaine or betaine anhydrous is a compound that consists of glycine with three attached methyl groups. It is produced by the body and is found naturally in beetroot and other foods. TMG can also be found in supplements, sometimes used to enhance athletic performance and improve heart and liver health.

David Sinclair has stated that he takes Trimethylglycine as an insurance policy against the loss of too many methyl groups while taking NMN. When too much NMN is converted to nicotinamide, this excess NAM is excreted out the urine with a methyl group attached, potentially causing levels to run low. Methyl groups are important for synthesizing creatine for muscles and dopamine for the brain. Low levels can be responsible for muscle fatigue and/or depression.

Spermidine is a powerful anti-aging drug that has been shown in studies to extend lifespan in model organisms including yeast, nematodes, flies and mice and has the potential to extend lifespan in humans as well. It does so by inducing a process known as autophagy, the bodys way of cleaning out damaged cells, in order to regenerate newer, healthier ones.

This ability to recycle cells and clear out dead and dying debris is known to have great anti-aging benefits in recent studies, possibly delaying the aging process in humans. David Sinclair has mentioned that he has added this important supplement to his stack in recent podcasts.

Sinclair has mentioned on Twitter that he also takes a prescription drug known as Statin. He takes it for a cardiovascular condition that is common in his family.

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David Sinclairs Anti-Aging Supplement List 2022 - Food Security

In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser therapy and platelet-rich plasma injections.

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To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.

Timestamps:

(00:00:00) Launching Episode Six: Combating Cosmetic Aging & Improving Skin, Nails & Hair

(00:02:54) Estrogen, Progesterone, and Menopause

(00:09:51) Thanking the Sponsors

(00:12:57) The Pinch Test, Epidermal Thinning, and Foot Ulcers

(00:18:29) Skin and Biological Aging

(00:23:19) Cellular Senescence, Ultraviolet Light, and Skin Aging

(00:28:15) Collagen, Keratin, and Skin Health

(00:33:38) A Quick Aside about Nails

(00:34:45) Autophagy and Retinoids

(00:36:57) Resveratrol, NAD Boosters, and Hyaluronic Acid

(00:41:44) Botox, Skin Peels, and Microneedling

(00:43:28) No Duh Stuff: Sun Damage, Smoking, Alcohol, and Bad Food

(00:45:42) Hair Loss and Hair Graying

(00:49:45) Topical Treatments, Pills, and Dihydrotestosterone

(00:55:19) Frickin Laser Beams: Low-level Laser Therapy

(00:57:59) Platelet-rich Plasma (PRP) Injections

(01:00:11) Hair Aging, Stress, and Gray Hair Reversal

(01:06:11) Targeting Aging Upstream

(01:07:37) Todays Takeaways

(01:09:25) Subscription and Support Options

For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Title Card Photo Credit: Mike Blabac

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

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