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Category Archives: David Sinclair

Is There Any Legitimate Health Advice in Gwyneth Paltrow’s "Goop Lab"? – InsideHook

Welcome toThe Workout From Home Diaries. Throughout our national self-isolation period, well be sharing single-exercise deep dives, offbeat belly-busters and general get-off-the-couch inspiration that doesnt require a visit to your (now-shuttered) local gym.

The word energy already had too many meanings.

Border Collie puppies barnstorming around a backyard are energetic. Cereal bars that contain fructose and maltodextrin give us the energy we need to get through an afternoon. Whirring wind turbines convert kinetic mechanical energy to electricity. Bitcoin mining uses as much energy (in terawatt-hours) year-over-year as the entire Czech Republic.

The word officially entered into overuse, though, on episodes five and six of The Goop Lab. The fifth episode, literally called The Energy Experience, features LA-based body worker and somatic energy practitioner John Amaral, who has patients lie down on massage beds as he plays with an undiscovered dimension in the air four to six feet away from their bodies. In the sixth episode, a medium named Laura Lynne Jackson beams energy into sitters, then interprets concepts the universe sends back to her to communicate with the dead.

There is little point in getting too worked up over the confounding definition of energy that Gwyneth Paltrow, her lifestyle empire, and this TV show a six-episode docuseries that dropped on Netflix about 10 weeks ago have entered into the words canon. During Goop Lab, discussions on energy feel somewhat reminiscent of a sophomore philosophy class where no one has actually done the reading. It is a cosmic entity, not necessarily meant to be understood, but apparently deserving of a wry smile, a bemused tilt of the head, a pat on the back for trying. This is the gray area though goop often colors it Easter pink where pseudoscience thrives, where phrases like food for thought and give it a go legitimize (if not blatantly prioritize) anecdotal accounts over blind clinical trials. Its why the internet was ready the second this series dropped in late January, its why the United Kingdoms National Health Service outright declared the show a considerable health risk to the public.

Of course, the NHS has had to battle far more considerable health risks than Paltrowism in recent weeks. And its alarmingly tempting, in the age of COVID-19, as we all turn into streaming service ultra-marathoners, to even seek out what is widely-agreed upon nonsense. Anything thats intertwined with personal health, too, at a time when were all thinking of our bodies how to boost our immune systems, how to sweat without doing the same run for the 13th time since shelter-in-place began is extra alluring.

With all of that out of the way, I have a confession. I quarantine-binged The Goop Lab in its entirety this weekend. I went in with an open mind, refusing to read a single scalding review beforehand (those came later and seriously, these writers had their takes ready, they might as well have been dropping obits) and actively searched for legitimate, usable strategies, practices or concepts I could apply to my personal fitness. Why take goop so seriously? It has a $250 million valuation, millions of followers across all relevant social platforms, hugely successful pop-up shops in cities across the States, and yearly wellness summits attended by high-profile actors, athletes and authors. It matters, whether you like it or not. And besides, I enjoy learning new ways to feel and perform better. An open, patient ear helps in that regard.

That ear had to hear the word energy exactly 4,000 times over the season, but there actually was, believe it or not, some relevant wellness knowledge hidden within all the Goopian muck. That muck generally followed the same format: Paltrow and her Chief Content Officer Elise Loehnen interview a couple special guests in a perfectly-lit office where people whod rather be drinking sangria pitchers under delicately hung Edison bulbs drink hemp tea while riding around on bubblegum pennyboards. The special guests, whove taken select goop staffers on some sort of retreat in the weeks or months preceding, get a chance to explain their research and dish on one staffer who had a particularly strong reaction to the experience. There are only three episodes worth watching within that framework, and just two special guests especially worth remembering. These episodes are the second, third and fourth: Cold Comfort The Pleasure Is Ours and The Health Span Plan.

This episode focuses on aging, and introduces the work of both Dr. Valter Longo, a cell biologist who works at the University of Southern California, and Dr. Morgan Levine, a professor in pathology at the Yale School of Medicine. Both are concerned with the concept of aging as disease; similar to the work of Harvard geneticist Dr. David Sinclair, who I had the chance to speak to just last month, Dr. Longo has shown that aging can be addressed at the molecular level with various lifestyle changes. For example, hes a big believer in calorie restriction (intermittent fasting) and a pescatarian diet.

Dr. Levine, meanwhile, employs blood work to test for inflammation, metabolism, kidney and liver function, and cardiovascular health to determine a persons chronological age. Think of it as a true or internal age. When contrasted with your chronological age, a biological age is a more accurate arbiter for your risk of cancer, heart disease, or diabetes. Personal fitness, much like personal savings, thrives best on information. Sometimes, you have to look at your account balance to plan a way forward. Talk to your doctor about the best way to get your blood tested, or consider a biological age test. There are a few out there, including myDNAge, TeloYears, and InnerAge. If the number is above your chronological age, dont panic. Thats where the work of Dr. Sinclair is so helpful; hes proven in Cambridge that fasting, exposure to cold temperatures and high-intensity interval training will literally put years on your life and high-quality years, at that.

Easily Goop Labs most celebrated episode, and for good reason. The star is Betty Dodson, a 90-year-old whos been teaching women how to orgasm since the 70s. Shes a gynecologist with Bourdain vibes, a patchy jacket and no hesitation in correcting Paltrows odd misunderstanding of female anatomy. (What GP considers the vagina at one point during the episode is actually the vulva.) If youre a woman, this is essential, long-overdue TV Goop Lab does well to show over a dozen different types of vulva, after a discussion on the disconcerting rise of labiaplasty surgery, which has long been a mainstay in the porn industry. Most courageously, though, the episode closes with the orgasm of Dodsons fellow sex educator Carlin Ross, whom she guides through the experience. How does any of this relate to wellness?

For women, improved sexual awareness and a reliable masturbation routine can help improve mood, aid in sleep, improve confidence and communication with partners, and even reduce pain from menstrual cramps. For men who have female partners, those are all good things. When supported, youll likely grow closer with your partner, and have a healthier relationship which, we all know by now, has massive affects on personal wellness. For those who dont (but hope/plan to, one day), its an important kick in the pants, a lesson that the orgasms performed through porn are just that, performances, and expectations need to be personalized and constantly reset or reconsidered depending on the women theyre seeing.

Ill admit, I was a little surprised to see Wim Hof himself on an episode of Goop Lab. He doesnt just look like Santa Claus hes borrowed a bit of his aura, a rare 21st-century legend. Upon hugging him, Paltrow even laughed Youre actually real! The Dutch extreme athlete made it over 7,000 feet up Mt. Everest wearing only a bathing suit and shoes. Hes run half-marathons completely barefoot, on the ice and snow. He once made full-body contact with ice for nearly two hours. Hes an absolute maniac, in other words, just sans David Blaine intensity. Hes far more mischievous, and able to tap into that secret sauce when needed, like the original, puppet-Yoda of Empire Strikes Back. On Goop Lab he has eight staffers practice the three pillars of the Wim Hof Method: cold therapy, breathing and meditation. They breathe into their bodies, aggressively, filling the rib cage with air, until their limbs start tingling and their minds go numb (Ive practiced this before, with a surf yogi in Hawaii; its nuts), allowing their thoughts to drift away. Then they practice 20 minutes of snow-ga barefoot flows in the snow along the banks of Lake Tahoe before actually jumping into the water.

It would all be so perfectly goop if only Wim Hof, and cold therapy werent actually scientifically corroborated. Exposure to cold water is dynamite for mental health, which is the main benefit Wim Hof touts in the episode; it encourages the release of neurotransmitters like dopamine, adrenaline, norepinephrine and serotonin, all of which have anti-depressive effects. But it isnt too shabby for the body in general, either; occasionally swimming around in a freezing cold lake, or committing to a bonkers-chilly shower has been shown to catalyze post-workout recovery, stave off injury, lower blood pressure, increase metabolic rate and stimulate the immune system.

Netflix captured one hell of a moment Wim Hof yelling into the California winter as editorial assistants jumped into 38F water and like all TV, I guess, thats what this show was ultimately about, good shots and better soundbites. The disclaimer at the beginning of each episode did indeed portend that Goop Lab wasnt meant to replace medical advice. But at least that scene meant something. It gave something to the world, a proven practice that might be worth introducing to our daily doldrums. And at the very least, it gave that tiny, mighty word, energy, a well-deserved break.

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Can canine coronavirus drug indomethacin be used in treating humans suffering from COVID-19? – MEAWW

A drug helped dogs fight off a type of coronavirus common in canines. Now, scientists believe the same drug might come to the rescue of humans suffering from COVID-19.

Though promising, the preprint study is preliminary. The study evaluated the drug Indomethacin against canine coronavirus. This virus, which is known to cause a highly contagious intestinal disease in dogs, shares ancestry with the new coronavirus.

Doctors prescribe indomethacin to reduce fever, pain, stiffness and swelling from inflammation. "Definitely worth additional testing of Indomethacin (Indocin), an anti-inflammatory from the 1960s, shown to inhibit CoV-2 & #coronavirus in dogs," tweeted Dr David Sinclair, from Harvard Medical School.

The focus is on old drugs because new treatments could take years to develop. "Given the urgency of the SARS CoV-2 outbreak, we focus here on the potential to repurpose existing drugs approved for treating infections caused by RNA viruses," the authors wrote in their study.

In one study, scientists showed that indomethacin can keep the SARS coronavirus a close relative of the new coronavirus from replicating inside cells. Scientists will learn more about its efficacy against the new coronavirus and its side-effects as they conduct more studies.

In this study, which has not been peer-reviewed yet, the team divided dogs infected with the canine coronavirus into three groups. Of the nine dogs that received an antiviral drug called ribavirin, three died. The second group fared a lot better. They received antibodies against the virus (anti-canine coronavirus serum) and only one dog died.

None of the dogs belonging to the third group died. Receiving Indomethacin, all the nine dogs survived the disease. What's more, dogs belonging to groups 2 and 3 recovered quickly.

"The results show, indomethacin can achieve a similar efficacy as treatment with anti-canine coronavirus serum, and superior efficacy than the treatment with ribavirin," the authors said.

As for lab-grown cells infected with the new coronavirus, they saw that indomethacin is toxic against the virus. Aspirin, on the other hand, was ineffective.

Drugs such as indomethacin and aspirin belong to a category of drugs called nonsteroidal anti-inflammatory drugs (NSAID). Doctors use them to treat pneumonia, which is common among severe COVID-19 patients.

However, some experts have raised an alarm against the class of drugs, suggesting that the drug might worsen the disease. "However, current scientific evidence does not indicate that patients with mildly symptomatic COVID-19 could be harmed by using NSAIDs," wrote Petros Ioannou, a post-doctoral researcher at the University Hospital of Heraklion, Crete, Greece, in the BMJ.

Earlier, France's health minister issued a warning against other NSAID drugs such as ibuprofen and cortisone. Other experts have said there is not enough evidence against the use of ibuprofen. The US Food and Drug Administration (FDA) issued a statement saying: "At this time, FDA is not aware of scientific evidence connecting the use of NSAIDs, like ibuprofen, with worsening COVID-19 symptoms. The agency is investigating this issue further and will communicate publicly when more information is available."

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Remembering loved ones who have passed away – the 68 death notices in North Staffordshire this week – Stoke-on-Trent Live

This week, these are the loved ones remembered in the funeral notices and family announcements in The Sentinel.

To see the full list of family announcements, visit this section of the StokeonTrentLive website where you can search by name, date and location. You can also post your own announcements and notices there.

You can also see the latest listings from your area on the InYourArea section.

Here are is a list of those to appear in North Staffordshire in the last week.

CAINE Lily

Passed away peacefully on March 16th 2020, at the R.S.U.H. Lily, aged 95 years of Dresden, (formerly of Bentilee). The dearly beloved wife of the late Joe, loving mum of Alma, dearest mother-in-law of the late Neil, much loved nan and great-nan of James and Eva.

Dearest sister of Jean and a very dear aunty. Lily will be sadly missed by all who knew her. A private service will be held at Carmountside Cemetery on Tuesday April 7th at 11:00am.

Floral tributes welcome, or if preferred donations for St. Mary's Church, Bucknall. Donations and enquiries to: Williamson Brothers Family Funeral Directors, Birch House, Birches Head Road, Hanley, ST1 6LH. Tel. 01782 212880.

GRIFFITHS Leslie John Les

After a short illness at the R,S,U,H on Thursday 19th March 2020. Les aged 88 years of Blurton. Much loved Husband to the late Edith, Treasured Dad to David, Neil and Linda, Also Father in law to Kelvin and Elaine and a dear companion to Joyce.

Les will be sadly missed by all his loving Family and Friends. A Private Funeral Service to be held at Carmountside Crematorium on Friday 3rd April 2020 at 10.00am,

Will all relatives please accept this only intimation. Flowers welcome or donations if preferred and made payable to Prostate Cancer UK. Mourners please disburse at the crematorium.

Due to Government restrictions and Social Distancing only 10 mourners will be allowed into the crematorium, This includes immediate Family members, Invitation only. Care of the Funeral Director.

All Enquiries to: Neil Venables Dolven Funeral Services Independent Family Funeral Directors 1 Nashe Drive, Blurton Stoke on Trent ST3 2HD 01782 599156

GROCOTT Terence (Terry)

At rest on 17th March 2020 at the RSUH, Terry aged 92 years of Shelton.

The dearly loved and devoted husband of Pauline, much loved dad of Lynda, Philip and Richard, loved father-in-law of Mandy and Susan, treasured grandad and great-grandad.

A private funeral service and cremation will take place at Carmountside Crematorium on Monday, 6th April at 2.30pm.

No flowers by request, donations preferred for the North Staffs Heart Committee. Donations and enquiries to Williamson Brothers Family Funeral Directors, Birch House, Birches Head Road, Hanley, ST1 6LH. Tel. 01782 212880.

HAYNES Wendy

Peacefully on 21st March 2020 at Haywood Hospital, Wendy aged 61 years, of Eaton Park.

The dearly loved wife of Alan, much loved mum of Sadie and Jennie, loved mother-in-law of Paul, treasured nannie of Emily, Liam and Addison, loving sister to Lesley and a loved sister-in-law, aunt and friend. Funeral arrangements later.

Enquiries to Williamson Brothers Family Funeral Directors, Birch House, Birches Head Road, Hanley, ST1 6LH. Tel. 01782 212880.

HOWLE Sheila

Suddenly on 5th March 2020 at her home in Berryhill, Sheila aged 69 years. The dearly beloved wife of the late Bill, much loved mum of Chris, Julie, Debbie and the late Sharon, loved mother-in-law, treasured nan and great-nan, a loving sister, sister-in-law, aunt and friend.

A private service and cremation will take place at Carmountside Crematorium on Thursday, 2nd April at 3.00pm.

Flowers or if preferred donations for Pink Sisters Staffs. Donations and enquiries to Williamson Brothers Family Funeral Directors, Birch House, Birches Head Road, Hanley, ST1 6LH. Tel. 01782 212880.

JERVIS Jill Mary

Peacefully at rest surrounded by her loving family on Tuesday 17th March 2020 at Beech Lodge Nursing Home Cheadle. Jill aged 81 years of Cheadle.

Loving and devoted Wife of John, cherished Mum of Tim and Justine and a dear Mother-in-law of Debby. Jill will be sadly missed but fondly remembered by all her loving family and friends. It is with sadness that a service cannot take place at Jill's place of worship due to the current government regulations, but instead a private service will be held at Carmountside Crematorium.

Will all relatives please accept this intimation, friends wishing to attend kindly meet at the above crematorium. Family floral tributes only please, donations if desired for the care of The Stroke Association.

Donations and enquiries to J.P Keates and Son Funeral Directors, Bank House, 37 Bank Street, Cheadle, ST10 1NR. Tel. 01538 752164 http://www.jpkeatesandson.co.uk

LAWTON Rita

At rest on 17th March 2020, at the RSUH. Rita aged 76 years, of Smallthorne. The dearly beloved wife of the late Graham, much loved and devoted mum of Steven, loving mother-in-law of Donna, loved and respected by Shirley and David.

Rita is fondly remembered and will be sadly missed by all who knew her. A private service and cremation will take place at Carmountside Crematorium on Tuesday April 7th at 12 noon.

Family flowers only please. Donations preferred for St Saviour's Church or Woolridge Court Comfort Fund. Donations and enquiries to: Williamson Brothers Family Funeral Directors, Birch House, Birches Head Road, Hanley, ST1 6LH. Tel. 01782 212880.

LEE Sharon

Suddenly on 12th March 2020 at her home in Bentilee, Sharon aged 41 years.

The dearly loved partner of Leon, much loved mum of Matthew, Meg, Joshua, Bethany and Billy, loved daughter of the late Sheila and Bill, a loving sister, sister-in-law, aunt and friend. A private service and Cremation will take place at Carmountside Crematorium on Monday 6th April at 10.30am.

No flowers by request. Donations preferred for the UHNM Charity Neonatal Unit. Donations and enquiries to Williamson Brothers Family Funeral Directors, Birch House, Birches Head Road, Hanley, ST1 6LH. Tel. 01782 212880.

MOUNTFORD Derek (Knocker)

At rest on 22nd March 2020 at Lawton Rise Nursing Home, Goldenhill, Derek, aged 80 years of Middle Port. The dearly loved and devoted husband of Audrey, much loved dad of the late Sharon and Nicola, loved father-in-law, treasured grandad and great-grandad, a dear brother, brother-in-law and uncle.

A private service and cremation will take place at Bradwell Crematorium on Wednesday April 8th at 2pm. No flowers by request, donations preferred for Alzheimer's Society.

Donations and enquiries to Williamson Brothers Family Funeral Directors, Birch House, Birches Head Road, Hanley, ST1 6LH. Tel. 01782 212880.

SPRUCE Derek

PRIVATE SERVICE ONLY

Peacefully at rest on 16th March 2020 at Springbank Nursing Home, Knypersley, Derek aged 89 years.

Dearly loved and devoted Husband of Margaret, beloved Father of Helen & David, Dear Father in Law of Eid & Melanie, Treasured Grandy of Andrew, Abbie, Nathan, Amy, Omar & Tarik, Much loved Brother in Law, Uncle & Friend to many.

Donations if desired to either Approach or Dementia UK. Enquiries to: John Garside & Son, 2 Cross Street, Biddulph, Stoke on Trent ST8 6BD Telephone: 01782 513210.

WILLIAMS Ivy (nee Marshall)

At rest on March 23rd 2020 at the RSUH, Ivy aged 89 years of Bucknall. Much loved wife of the late Bob Marshall and the late Ted Williams, devoted mum of Linda, Stephen, Gary and Robert, dear mother-in-law and a cherished nan and great-nan.

Ivy will be fondly remembered by all her family and friends. A private graveside service will be held for Ivy's immediate family only at St Mary's Church, Bucknall.

Family flowers only please, donations if desired for Cancer Research UK. Donations and enquiries to Williamson Brothers Family Funeral Directors, Birch House, Birches Head Road, Hanley, ST1 6LH. Tel. 01782 212880.

WOOLRIDGE Graham

Peacefully at rest on Monday 16th March at The RSUH, Graham aged 77 years of Dresden, devoted husband of Margaret, much loved dad of Neil and a dear father in law of Jacqui, treasured grandad of Ross and Todd and their partners Lucy and Amy, great-grandad of Mai-Rose the apple of his eye, and dear brother of Jean. Graham will be sadly missed by all his family and friends.

Family flowers only please. Private family funeral service and cremation to be held at Carmountside Crematorium.

Share your condolences online at funeral-notices.co.uk where you can also donate to The British Heart Foundation in the memory of Graham. Enquiries to:- W.R. BETTELLEY Funeral Directors, 315 Uttoxeter Road, Longton, Stoke on Trent, Tel. 01782 313542

BAILEY David

Suddenly at home on 13th March 2020, David Sinclair aged 60 years of Whitmore.

The dearly loved husband of Catherine, loving dad of Georgina and Louisa and a dear brother of Adrian and Phillip. Due to the crisis we are all experiencing, a private family funeral will take place, but a Service to Celebrate David's life with all family and friends will be announced in due course.

Donations in David's memory may be made to the Douglas Macmillan Hospice and the R.N.L.I. All donations and inquiries to JOSEPH EDWARDS & SONS, Independent Funeral Directors of Alsager and Kidsgrove. Tel: 01270 882097 or 01782 775333.

BOON John Aubrey

PRIVATE SERVICE ONLY. At rest at the Royal Stoke University Hospital on 18th March 2020, John, aged 86 years of Biddulph. Devoted husband of the late Ellen Boon, dearly loved Dad of Angela, Colin, Gary, & Gay, loved Father in law of David, Jill, Sue & John, Cherished Grandad of Michelle, Lee, Mark, Natalie, Sophie & Georgi, Great Grandad of Jaymie-Leigh, Jake & Lillie also a very dear Brother & Brother in law.

John will be sadly missed by his family & friends. A Private Service will take place on Monday 6th April 2020. Donations please in lieu of flowers to St Lawrence Church.

Enquiries to: John Garside & Son, 2 Cross Street, Biddulph, 01782 513210.

BRADBURY John Cyril

Passed away peacefully surrounded by his loving family on 19th March 2020. The dearly loved and devoted husband of Gwen and much loved Dad, Grandad and Brother.

Will be fondly remembered and sadly missed. Due to the Covid 19 outbreak a private cremation service will take place.

A celebration of John's life will be arranged at a later date where all John's family and friends can safely attend. Donations to Royal Stoke University Hospital.

All inquiries to: Harold H Leese (A.Boulton & Sons) Funeral Directors & Memorial Masons St Peter's Close Stoke on Trent Staffordshire ST4 1LP

CARP Mike

Suddenly on 7th March 2020 at the R.S.U.H. Michael John (Mike) aged 69 years of Brown Edge and formerly of Stockton Brook, devoted husband of Susan, much loved dad of David, father-in-law of Clare, loving grandad of James, brother to Russell and Jean and a dear brother-in-law, uncle, nephew and friend to many.

Funeral private, family flowers only please, donations to Multiple Sclerosis. Inquiries to S. Sigley & Sons, Leek Tel 01538 382048

COLCLOUGH Nora

Peacefully at rest on Sunday 15th March 2020 at the R.S.U.H. Nora aged 91 years of Tean. Dearly beloved wife of the late Christopher George. Much loved and loving mum of Robert.

Devoted grandma of Helen and Emily and great grandma of Callum. Also dear sister of Ron Tranter. Nora will be sadly missed by all her loving family and friends.

The Funeral Cortege will leave Harry Dawson Funeral Services on Tuesday March 31st at 11.30am for service and cremation at Carmountside Crematorium at 12.00 noon.

Due to unprecedented circumstances surrounding COVID - 19 ( Coronavirus Pandemic ) Nora's funeral will remain private for all except close family members.

No flowers please by request donations preferred for The Douglas Macmillan Hospice Blurton c/o The Funeral Director.

Donations & Enquiries to NICOLA DAVIES HARRY DAWSON FUNERAL SERVICES 105 Upper Normacot Road Normacot, Longton. Tel : 313428.

COTTON ALAN

Bernard Suddenly, after a long illness, at RSUH on Monday, 16th March, 2020, surrounded by his loving family, Alan aged 89 years of Longton.

Beloved husband of the late June, much loved dad to Jane and Lynn and father-in-law to Darren, a treasured grandad, great-grandad and a dear brother Private family funeral service and cremation to be held at Carmountside Crematorium Family flowers only please.

Share your condolences online at funeral-notices.co.uk where you can also donate to British Heart Foundation in memory of Alan Enquiries to:- W.R. BETTELLEY Funeral Directors, 315 Uttoxeter Road, Longton, Stoke on Trent, Tel. 01782 313542

GOLLINS Esther Ann

Peacefully at rest on Monday 16th March 2020 at her home, aged 86 years of Madeley. Beloved wife of Peter, dearly loved mum to Amanda, Christine and the late Christopher.

Esther will be sadly missed, but fondly remembered by all her loving family and friends. Funeral service and cremation to be held at Bradwell Crematorium on Friday 3rd April 2020 at 9.20am.

Would relatives and friends kindly meet at the crematorium. Family flowers only, donations if so desired to Marie Curie Nurses. All inquiries to: MARSH & SON Funeralcare 36 Friarswood Road, Newcastle Tel. 01782 717019.

HANCOCK Lionel Robert (Coal Merchant)

At rest on 17th March 2020 at the Royal Stoke University Hospital, Lionel aged 80 years of Bradwell. Devoted husband of the late Jean, treasured dad of Sean and Diane, father in law of Annette and John, much loved grandad of Nathan, Maxine, Brett and Ellie, great grandad of Nelly and a beloved partner and soulmate of Rita. Lionel will be sadly missed but fondly remembered by everyone who knew him.

Funeral Service to be held at Bradwell Crematorium on Tuesday 31st March 2020 at 12.40pm.

Family flowers only please donations would be much appreciated to Douglas Macmillan Hospice and Pancreatic Cancer UK. Hopkinson Wootton Lovatt Hopkinson House, 15 Chetwynd Street, Wolstanton, ST5 0EQ. Telephone: 01782 715152. http://www.hopkinsonwoottonlovatt.co.uk

HARRISON Peter

Passed away peacefully on 5th March 2020 at Glan Clwyd Hospital, Bodelwyddan, Peter aged 60 years. The dearly loved and devoted Husband of Anne. Brother of Anne, Brother in law of Roger and Julie. Uncle of Simon, Michelle. Great Uncle of Lauren, Ashton, Logan, Jaxon, Lucas. Great Great Uncle of Shelby and Eliana. Service and Cremation to take place at Bradwell Crematorium on Thursday 2nd April 2020 at 1.20pm.

Will relatives please accept this the only intimation and friends wishing to attend kindly meet at the Crematorium. Family flowers only donations if desired to BCU HB Glan Clwyd Hospital ITU Department.

All enquiries and donations to Alan Finneron Funeral Directors, 32 West Street, Congleton CW12 1JR Tel 01260 277622. http://www.afinneron.co.uk

JOHNSON Harvey

Peacefully at home on Tuesday 17th March, 2020, much loved dad of Pat, Peter and Kath, grandad and great grandad.

Reunited with his loving wife, the late Kath. Resident of Abbey Hulton, the funeral service and burial will take place on Friday 3rd April at Carmountside Cemetery at 12.30pm.

Family flowers only by request, donations in lieu of flowers can be made to Cancer Research UK. Funeral enquiries to: Coop Funeralcare, Leek Rd, Abbey Hulton Tel: 01782 535184.

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7 books to read while in coronavirus quarantine or isolation – The CEO Magazine

If you, like much of the world, find yourself twiddling your thumbs in self-isolation amid the ongoing coronavirus pandemic this book list is for you.

In the words of the great Susan Sontag, The day has pockets you can always find time to read.

And because we have no idea how long the COVID-19 crisis will continue, many of us are faced with a lot of time to kill.

From entertainment and escapism to a dystopian novel thats eerily similar to the current climate, these books will enrich your self-isolation.

Stephen King It starts with a cough, then your neck swells, your nose starts to bleed and your eyes bulge out of their sockets. Death comes just hours later. Kings 1978 novel follows the breakdown of society after a strain of the flu that has been modified to be used for biological warfare is accidentally released, killing 99% of the population. Its then up to a tiny handful of survivors to rebuild society. Comparisons between COVID-19 and Kings fictitious flu are already being made, with the author tweeting in response, Its not anywhere near as serious. Its eminently survivable. Keep calm and take all reasonable precautions.

Sheryl Sandberg This game-changing book became an international bestseller for good reason. Facebook COO Sheryl Sandberg has had decades of experience climbing the corporate ladder at successful technology startups all while balancing family life. She covers everything from how to find a mentor at work to voicing your opinion, becoming a leader in your organisation, forging an equal partnership in your home life and what true equality should look like in the workplace. Balancing light humour with solemn advice, Lean In is a call to action for personal growth that can empower women around the world to achieve their full potential.

Mark OConnell Insightful, life-affirming and slightly terrifying, this book follows OConnell as he travels the globe in search of answers regarding the impending climate apocalypse. He tours survival bunkers in South Dakota, visits the billionaires bunkers in New Zealand and interviews everyone from doomsday preppers to conspiracy theorists. With insight, humanity and wit, OConnell leaves you wondering, What if the end of the world isnt the end of the world?

David A Sinclair What if everything weve been taught to believe about ageing is wrong? What if we could choose our lifespan? The paradigm-shifting book from David Sinclair, acclaimed Harvard Medical School scientist and one of Times most influential people, reveals a bold new theory for why we age. He posits, Ageing is a disease, and that disease is treatable. At a time when the health of the world is threatened, this book will change the way you think about ageing and what we can do about it.

Jessica Anthony What does taxidermy have in common with the current American political climate? A lot, according to Jessica Anthony. Inventive, original and darkly funny, this novel examines how and why a young Republican congressman discovers a mysterious stuffed aardvark placed on his doorstep. It then leaps between contemporary Washington DC and Victorian England, where readers meet the taxidermist who stuffed the creature and the naturalist who hunted it, offering a uniquely unsettling view of how male power has evolved over time.

James McBride The National Book Award winners dazzling, spiritually rich novel opens in 1969 when a boozy Brooklyn deacon guns down a drug dealer. The incident brings together an array of social groups from the African-American and Latinx residents who witnessed the crime to the members of the deacons church as they seek to understand why the violence occurred and how it relates to the multicultural history of their community.

Quan Barry Almost 300 years after the witch trials, a Massachusetts high school field hockey team is determined to make it to the state finals. After a losing streak, their luck starts to turn around after team members begin signing their names in what might be a magical notebook. The novel evolves into a nostalgic coming-of-age story that explores the teams mission to win and their experimentation with witchcraft.

Read next: 10 podcasts to binge right now

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Flipping the switch on the ageing process – The Age

Sinclair was scheduled to discuss his ideas with Norman Swan, host of Radio Nationals Health Report, at Ageing is a Disease at Sydney Town Hall on April 4 as part of the Festival of Dangerous Ideas, which was cancelled last week.

David Sinclair says ageing fulfils every criteria for what medical textbooks define as a disease.Credit:Nic Walker

Sinclair says the coronavirus pandemic, which is causing a higher fatality rate among the elderly, gives urgency to his research into the ageing process. "Our research is aimed at delaying or reversing age-related diseases and providing the elderly with resilience," he says. "Other labs have shown in human clinical trials that immune responses in the elderly can be boosted by molecules that target ageing, such as low dose rapamycin."

But Sinclairs argument that ageing is a disease may cause some unease. He says ageing causes frailty, sickness and eventually death, fulfilling every criteria for what medical textbooks define as a disease. The only difference is that ageing happens to everyone, whereas cancer and heart disease do not. Were very good at preventing heart disease but we havent been successful at delaying ageing of the brain, he says. So weve ended up with the worst nightmare - were increasing lifespan but not healthspan as much.

"Its also not recognised that age is what causes those diseases in the first place," he adds.

Describing ageing as a disease also sounds to some ears like it is stigmatising older people. I find that people over 50 tend to get upset when you call ageing a disease, he says. But people under 50, particularly people in their 20s and 30s, they totally embrace this idea. They don't want to get sick. They think technology can solve everything.

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Sinclairs book Lifespan, subtitled Why We Age, and Why We Don't Have To, outlines his 25 years of research into ageing, which he likens to corrupted software.

Getting older amounts to a loss of what he calls epigenetic information. Essentially its the information that tells the cells how to read the genes in the right way and stay young, he says. In the same way that a genome is the computer, the epigenome is the software. And so I'm proposing that ageing is corrupted software.

Sinclair says his research has also revealed there is a back-up copy of our software. If its corrupted, weve figured out a way to reboot the cell and be young again.

In Lifespan, he describes experiments in which old mice have been given gene therapy that restores their eyesight to that of young mice. The idea is we still have all the information to be young again in our bodies if we can just flip the switch, he says.

Sinclairs effort to reboot cells is undergoing pre-clinical trials to test the safety and efficacy of the procedure. Within the next three years, he aims to treat patients who have lost their vision as a result of glaucoma - a disease that can be controlled but cannot be cured.

Do I know if its going to work in people? he says. Of course not. Nobody knows until you do the clinical trials.

Sinclairs research into ageing is slowly gaining acceptance among scientists and medical professionals. British scientists Robert Faragher and Stuart Calimport said last year on academic website The Conversation that the World Health Organisations International Classification of Disease should be amended to classify ageing as a disease.

However, Sinclair says it is hard to change regulations and the habits of doctors who have been taught that ageing is inevitable and not something we can treat.

It takes radical thinking to overcome what youve taken for granted your whole life, he says.

Sinclair traces his interest in ageing to childhood and a conversation with his grandmother Vera. I remember very clearly that my grandmother told me everything is going to die, he says. The cat was going to die, she was going to die and my parents and I would.

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Sinclair describes his grandmother as a huge rebel who taught him to question dogma and authority. He recalls with pride how she was ejected from Bondi Beach in 1957 for wearing a bikini one year after she fled Hungary following the Soviet invasion. She taught me that humans can do evil and can do amazing good, he says. And she said: David that's what you should do with your life is leave the world better than you found it.

Sinclair says his aim is not to cheat death, but to allow older people to stay healthier for longer. There are plenty of people who look at what its like to be 100 and say Heaven forbid, I don't want to get old, he says. But thats missing the point, which is you could be 80 or 90 and still play tennis and hang out with your grandkids and be productive like my father is at 80.

Sinclair says preventing illness is the key to improving quality of life and reducing the burden on family and society. Its what we see in our animal studies, he says. They live longer because theyre healthy. Thats the only way I know to keep something living longer is to prevent them getting sick.

However, Sinclair cautions that his research will not deliver the magic bullet that allows people to eat, drink and be merry without consequence. If you live a healthy lifestyle and eat all the right foods are you going to live beyond 120? Probably not, he says. On the other hand, the average lifespan for humans used to be about 40 years. And weve used technology to improve our health - thats what we do as human beings."

Andrew Taylor is a Senior Reporter for The Sydney Morning Herald.

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Flipping the switch on the ageing process - The Age

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Pilot Wins Top Honors at Awards Ceremony | Business – Southern Pines Pilot

From left, Pilot staff photographer Ted Fitzgerald, reporter Laura Douglass, editor John Nagy, reporter Jaymie Baxley, and The Sway's Mackenzie Francisco, Melissa Kohlman, and Abbi Overfelt. Photo: David Woronoff/The Pilot

The Pilot took home the prestigious first place award in General Excellence in its division at the annual North Carolina Press Association News, Editorial and Photojournalism contest held Thursday.

The 2019 awards were presented Thursday as part of the NCPAs Winter Institute. More than 100 newspapers from across the state were represented and 4,400 entries were submitted..

In competition among non-daily community newspapers with circulation over 10,000, The Pilots staff members accounted for 16 news and editorial and 19 advertising awards presented at the Marriott Crabtree Valley in Raleigh.

The Pilot has previously earned the top award for General Excellence in 2017, and 2010. The Pilot placed third in that category in 2015 and last year.

Our core purpose has always been to serve our community. We believe that publishing a great newspaper is the best service we can render, said Pilot publisher David Wornoff. While were proud of this award as it recognizes the outstanding work of our dedicated staff, its the pride that our readers feel for the newspaper that brings infinitely more satisfaction.

In addition to print content, The Pilot swept the email newsletter category, taking first place for the twice-weekly Pilots Briefing, and second and third place honors for The Sway.

The top prize for best niche publication went to Pinestraw magazine, produced by The Pilot; and the special section Best of The Pines earned first place in the category, with A Guide to the Sandhills taking second place.

Publisher David Woronoff and editor John Nagy earned first place for editorial page, and Nagy took home third place in the individual category for editorials.

An emphasis on the transparency, and consequently the quality, of local government provides a service to readers of The Pilot, the judges said.

Among the other individual news awards to members of The Pilot staff, writer Deborah Salomon took first place in beat feature reporting and third place in feature writing.

Reporter Jayme Baxley took second place for sports enterprise writing.

Managing editor David Sinclair took third place in sports columns and third place in sports feature photography.

Staff photographer Ted Fitzgerald slid into second place in sports feature photography and third place in photo page or essay.

Fitzgerald, Sinclair and Brandi Swarms also earned third place in the feature photography category for their front page coverage of area high school graduation ceremonies last June.

The recognition of our peers is gratifying, but the feedback that means more to us is what we receive from people in the grocery store aisles and at church and around town, said editor John Nagy. The Pilots strength has always been and remains the connections its people have with their community.

In a separate ceremony Thursday afternoon, The Pilots advertising staff collected 19 awards for their work, including top honors for best overall performance for the third consecutive year.

Patty Thompson and Scott Yancey racked up an impressive number of first place awards in advertising categories, including healthcare and medical, best home furnishings and appliance ad, for a retail ad and, separately, a service ad in a niche publication.

From left, ad rep Samantha Cunningham, advertising director Ginny Trigg, and graphic design manager Mechelle Butler.

Yancey also earned first place with Dacia Burch for best apparel, jewelry and accessories ad.

The Pilots ad staff earned first place in the community services signature page for their Valentines Gift Guide, first place and second place in the niche publication category, and first place and third place for special section.

Wow. Just wow, the judges said. Every page is gorgeous photo, content, layout work together with flare, elegance and personality.

Thompson and Yancey also individually took second place for apparel, jewelry and accessories ad and healthcare medical ad.

Perry Loflin and Yancey took second place for retail ad in a niche publication.

A third place award was presented to Burch and Yancey, and Terry Hartsell and Mechelle Butler for home furnishings and appliance ad. Additional third place prizes were awarded to Thompson and Yancey for retail ad, and Butler and Samantha Cunningham for use of color in advertising.

Were so proud of the fantastic work that our advertising team produces all year long, said Ginny Trigg, The Pilots advertising director. It's especially rewarding to be recognized by our industry peers for the ads that were creating. We share the awards with our advertising partners for trusting us with their marketing.

The Pilots winning advertisement partners included CoolSweats, Monkees of the Pines, Burney Hardware, Wedgies, Bell Tree, Sweet Dreams Mattresses and More, Elmore Furniture, Pinehurst Medical Clinic, Karma Beauty Bar, Sothebys, The Ice Cream Parlor.

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Pilot Wins Top Honors at Awards Ceremony | Business - Southern Pines Pilot

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