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The secret to longevity: low-stress – Industry Global News 24

Posted: December 12, 2019 at 7:49 pm

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The secret to longevity: low-stress - Industry Global News 24

Recommendation and review posted by G. Smith

Reba McEntire Shares Her Secrets on Success, Longevity, and Staying Humble – Thrive Global

Posted: December 12, 2019 at 7:49 pm

Global star and widely loved country music artist, actress, and humanitarian Reba McEntire celebrates her 16th Grammy Award nomination this year for her album, Stronger Than The Truth, which has resonated deeply within the country music community. One of the greatest selling country artists of all time, McEntire has previously won the Grammy Award for Best Female Country Vocal Performance, Best Country Vocal Collaboration, and Best Roots Gospel Album, and she has also been nominated for a Golden Globe award and more.

We sat down with the reigning Queen of Country Music to talk her Best Country Album nomination, how she turned her passion into a hugely successful career that has spanned over four decades, and advice for other female artists. You can tune into the 62nd Grammy Awards on January 26, 2020.

Where were you when you received the news of your 16th Grammy Award nomination?

I was at home in Nashville and my phone started blowing up around 7:30 a.m., right as the nominations were announced. My entire team texted me to let me know the news! There were a lot of excited emojis!

How does this years Best Country Album nomination compare to the one you received in 1994 for Read My Mind?

Im incredibly proud of both albums. I still love music now just as much as I did then, and I still follow the same formula I did then pick great songs that touch my heart and hopefully theyll touch yours, too.

How does this nomination stand out amongst the other 15 you have previously received?

I wanted to go back to my roots on this album and make a stone-cold country album with great story songs. To be recognized for that some 30 years after my very first nomination is pretty special. Its just icing on the already really wonderful cake.

What about Stronger Than The Truth do you think resonated with the Recording Academy?

Its honest and authentic. Its full of songs that tell stories that I think anyone can relate to.

From your first nomination (and win) in 1986 to now, the 2020 Grammys, how has your outlook on awards and accolades changed?

Im still as competitive as Ive always been, but the pressure is less now. Of course I love to win awards, who doesnt? But now I take pride in knowing that Ive made the best album that I possibly could and that is my reward, whether I take home a trophy or not.

Many of the songs on your album have been on your radar for years. How does it feel to see these songs officially having their moment of recognition?

Im just thrilled to see great songs being recognized, and Im thankful for all the writers letting me be the conduit for their work.

How does it feel to have your music consistently recognized for over three decades?

Well it feels great! I, and my entire team, work very hard to put out music that means something and connects with the listener. Im beyond grateful to still have the platform that I do and I take it very seriously.

Thats why I do this I want the music and the songs to reach out and touch people and make them feel like theyre not alone and that someone else understands.

You most recently took home the award for Best Roots Gospel Album in 2017. How have you incorporated your faith into your country records, and what similarities do you see between the genres?

My faith is part of everything I do. I pray every day that the Lord will use me and guide me in my all my decisions. I may not be singing directly about God and Jesus, but that doesnt mean the ideas arent there. Songs like You Never Gave Up On Me on this record could be about someones relationship with the Lord. Theres always been an overlap between Christian and country, and I think there always will be.

Stronger Than The Truth is your 33rd studio album a tribute to your success and fame. What has allowed you to remain grounded? How do you not let the pressures of success change you?

My family and my friends keep me grounded. No ones going to let my head get too big and they bring me back down to Earth real quick if I get to floating off too far. My sister, Alice, gave me a toilet seat cover one time for Christmas that on the top said, The Twinkle! So Im still working on being that star.

What has been the most unexpected joy you have received from creating this album?

Hearing how the songs have touched peoples hearts. Ive had people tell me they couldnt listen to the entire album through at one time because it was just too emotional for them. Thats why I do this I want the music and the songs to reach out and touch people and make them feel like theyre not alone and that someone else understands.

What things have industry peers shared with you about how they feel about this album that have surprised you? Is there anything that you didnt expect?

Ive had people come to me in tears with how much the songs have impacted them. I was just trying to make a great country record, and if people cry, that means we have touched their hearts. Making that connection is sweet.

What do you think sets you and this album apart from the other nominees?

I think weve all made really great albums, but were all very different and in different stages of our careers. I think its really great to see such diversity represented in the category with all types of country music.

Are there any moments from your past Grammy experiences that stand out to you? If so, what are they?

Winning the Grammy for Sing It Now is something Ill never forget. I made that record as a way to heal my own heart, and to see it connect with so many other people and then be recognized in that way meant the world to me.

What does it mean to you to be nominated for Best Country Album this year?

I dont take it for granted. There are a lot of great artists making incredible music out there every day, and I feel very honored to have my work recognized as standing out among the crowd.

If you could share one piece of advice with female artists getting their start, what would it be?

Stay true to your gut instincts. Ive always felt that is Gods way of directing me. Stay with the type of music you want to be making and what type of artist you want to be. Stand your ground and make music that youre proud of. Everything else will work itself out. Work hard, show up on time, be prepared and have fun!

Excerpt from:
Reba McEntire Shares Her Secrets on Success, Longevity, and Staying Humble - Thrive Global

Recommendation and review posted by G. Smith

Key to longevity – THE WEEK

Posted: December 12, 2019 at 7:49 pm

The Adi Parva of Mahabharat has the story of a father who exchanged his old age with the youth of his son. King Yayati, the father, loses his youth and becomes a decrepit old man because of a curse by sage Sukracharya. But the sage gives Yayati a concession: he could regain his youth if he finds somebody to exchange his old age with. Filled with insatiable thirst for sensual pleasures, Yayati demands his son Puru to offer his youthfulness.

The mythical story from the epic exemplifies that combating ageing and mortality has always been a concern of humankind. There is plenty of research going on in this field today, though some ethicists say these would result in a denial of the natural limits of human existence. Recently, a significant milestone in this field was achieved by scientists from the RIKEN Centre for Integrative Medical Science and Keio University of Medicine, Japan. They found that super-centenarianspeople over the age of 110have an excess of a type of immune cells called cytotoxic CD4 T cells. The finding could be a breakthrough in exploring the key to longevity.

Super-centenarians are a rare group. In 2015, Japan had more than 61,000 people over 100, but just 146 over the age of 110. Studies have shown that most super-centenarians spend their entire life without any major ailment, which implies their immune system always remained active against all sorts of infections and tumours. However, medical science is yet to explore more about their immunological condition.

The Japanese researchers studied circulating immune cells from a group of super-centenarians (41,208 cells) and young controls (19,994 cells), respectively, as part of their study. They found that the number of T cells was approximately the same in both groups and the number of a subset of T cells had an increase in the super-centenarians. T-cells have a unique ability to acquire cytotoxic activity and directly kill cancer cells, cells that are virus-infected or cells that are damaged in other ways.

Normally T-cells with markers known as CD8 are the ones to show cytotoxic capabilities. Those with CD4 markers (known as helper cells) generally perform regulation of immune responses, and not cytotoxic functions. However, researchers found that CD4 cells in super-centenarians had acquired a cytotoxic status. Interestingly, the blood of young donors had relatively few cytotoxic CD4 cells. It suggests that increased and cytotoxic nature of CD4 is unique to super-centenarians. To understand how these special cells were produced, the researchers examined the blood cells of two super-centenarians in detail. They found that they had arisen from clonal expansiona process in which many of the cells were the progeny of a single ancestor cell.

The research published in Proceedings of the National Academy of Sciences makes the conclusion that cytotoxic CD4 cells which are relatively uncommon in most individuals could be useful to fight established tumours, and also for immune-surveillance. Seems like the Mahabharat story is getting reversed: the super-centenarians may soon help the younger generations to stay healthy.

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Key to longevity - THE WEEK

Recommendation and review posted by G. Smith

Pensions are key driver of Britons household wealth – Financial Times

Posted: December 12, 2019 at 7:49 pm

Pensions are key driver of Britons household wealth  Financial Times

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Pensions are key driver of Britons household wealth - Financial Times

Recommendation and review posted by G. Smith

Optimism can help you feel — and be — better – Daily Press

Posted: December 12, 2019 at 7:49 pm

In the mid-20th century, the self-help book by Norman Vincent Peale popularized the phrase, the power of positive thinking. Winston Churchill succinctly summarized this philosophy best, a pessimist sees the difficulty in every opportunity, and an optimist sees the opportunity in every difficulty.

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Optimism can help you feel -- and be -- better - Daily Press

Recommendation and review posted by G. Smith

Study with centenarians finds novel protein signature of protective APOE genotype – National Institute on Aging

Posted: December 12, 2019 at 7:49 pm

A novel protein signature may have the potential to serve as a biomarker for resistance to Alzheimers disease and cognitive decline, according to a new study with a group of centenarians and their offspring. The researchers found a correlation between 16 proteins found in blood and the 2 form of the apolipoprotein E (APOE) gene. The study, led by investigators at Boston University in collaboration with the NIA Intramural Research Program and Novartis, was reported in Aging Cell.

Having the 2 form of the APOE gene is thought to be neuroprotective, whereas having the 4 form is associated with increased risk of late-onset Alzheimers disease and poor cognitive function. The 2 form, which is much rarer than 4, is more commonly detected among those over 100 years old and their children than in the general population. APOE 2 also seems to promote longevity, but the precise biological mechanisms for it being neuroprotective and promoting long life are not known.

Because recent studies showed that APOE-associated protein products can be found in blood serum samples, the researchers analyzed serum to find the biological products of APOE 2. Serum was collected from 222 people in the NIA-supported New England Centenarian Study, including 51 with APOE 2.

Using a protein profiling platform to analyze several thousand proteins in serum that corresponded to more than 4,000 genes, the researchers found that 16 proteins were associated with different APOE genotypes. They explored the different gene expression profiles of 16 proteins in brains of people with late-onset Alzheimer's disease and healthy controls and showed that the signatures were significantly different between the two groups.

Next, they confirmed their findings by repeating the analysis with serum and plasma samples from other cohort studies. Finally, they examined the association between the 16 proteins and changes in cognitive function in the centenarians and found that seven of these proteins correlate with patterns of cognitive function.

If future studies show that the signature proteins are driving cognitive health, rather than merely being associated with it, these proteins could serve as biomarkers in intervention studies targeting APOE 2. In addition, the protein signature identified in this study could be developed into an early detection test of resistance to developing Alzheimers.

This research was supported in part by the NIA Intramural Research Program; NIA grants U19AG023122, R21AG056630 and R01AG061844; and NIH contracts 263 MD 9164 and 263 MD 821336.

Reference: Sebastiani P, et al. A serum protein signature of APOE genotypes in centenarians. Aging Cell. 2019;18(6):e13023. doi: 10.1111/acel.13023.

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Study with centenarians finds novel protein signature of protective APOE genotype - National Institute on Aging

Recommendation and review posted by G. Smith


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