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Broken chromatin fragments could hold the key in the fight against the deadly sepsis – Research Matters

Posted: May 28, 2020 at 11:48 am

Sepsis is a potentially life-threatening condition, where the body's immune response to an infection goes overdrive and starts to attack healthy cells. This condition leads to tissue damage, organ failure, immune paralysis, and ultimately, death. About 49 million people suffer from sepsis every year, and a fifth of them succumb to it. The death toll from sepsis is much higher than all cancers combined. Despite its high prevalence, the underlying mechanism of how sepsis develops is not well understood, and there is also no treatment.

Building on their previous research, researchers at Tata Memorial Centre (TMC), Mumbai have tried to find out the root cause of sepsis in a recent study. So far, most drugs treat the symptoms of sepsis, such as inflammation, rather than its causes. In this study, the researchers find that broken pieces of chromosomes could trigger sepsis. The results of the study are published in the journal PLoS ONE.

In a healthy individual, billions of cells die each day and release their chromosome particles, called cell-free chromatin. Healthy cells can absorb these particles, leading to cell death and inflammation. In the current study, the researchers hypothesised that these cell-free chromatin trigger sepsis by integrating into and disrupting the DNA of healthy cells. As a result, the healthy cells die, further releasing more chromatin, and a vicious cycle is perpetuated leading to sepsis.

The researchers prepared three different compounds for inactivating the deadly chromatin particles to test their hypothesis. The first was anti-histone antibodies attached to nanoparticles that target the packaging component of chromatin called histones. The second was an enzyme called deoxyribonuclease I, which degrades the DNA of cell-free chromatin. A third, which was a novel combination of resveratrola plant-based antioxidant extracted from the skin of red grapesand copper, which degrades DNA in the chromatin via free radicals.

The drugs were tested in mice injected with a bacterial toxin called lipopolysaccharide. The researchers investigated if the broken chromatin particles would be inactivated, and the sepsis, caused by this toxin, would be cured. They then monitored the levels of cell-free chromatin in different organs and the level of cytokines, which initiates inflammation, in blood and various organs.

The results showed that the use of all three drugs resulted in a downward trend for the parameters of sepsis. Of the three, the combination of resveratrol and small quantities of metallic copper was the most effective.

"Our studies have shown that a combination of the antioxidant resveratrol and small quantities of copper may be of therapeutic effect," says Prof Indraneel Mittra. He is a Professor at the Tata Memorial Centre and the corresponding author of the study.

The findings of the study have broad applications beyond treating sepsis.

"The promise of this study is not limited to the treatment of sepsis. It branches out to improve the side effects of chemotherapy as well", mentions Prof Mittra.

The researchers had previously established that the toxic side effects of chemotherapy are also due to the cell-free chromatin generated by cells that are killed by the drugs. "They then kill other healthy cells," he adds.

The effectiveness of Resveratrol and Copper in treating sepsis may suggest an Ayurvedic angle.

"Ayurveda is replete with plant products related to Resveratrol, like haldi, amla and nimbu. Copper is also a commonly used metal in Ayurveda. With centuries of experience, Ayurveda has observed that plant products and heavy metals are beneficial to health. However, the synergistic effect between two hasn't been scientifically tested. Maybe our discovery of therapeutic effects of Resveratrol and Copper might help to provide clues to the secrets of Ayurveda," signs off Prof. Mittra.

This article has been run past the researchers, whose work is covered, to ensure accuracy.

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Broken chromatin fragments could hold the key in the fight against the deadly sepsis - Research Matters

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10 Best Red Wines of 2020 – Best Red Wine for Health –

Posted: May 28, 2020 at 11:48 am

A good glass of red wine is one of lifes great pleasures. Its also one of the healthier alcoholic beverages to choose. Red wine has less natural sugar than white, and it boasts more iron, potassium, and carotenoids (good for eye health) too. While studies are mixed on resveratrol, a buzzy antioxidant found in red wine, its possible that these polyphenols may help prevent damage to blood vessels and protect against cholesterol buildup. Obviously, you shouldnt drink wine to get your daily nutrients or think of it as your main defense against heart damage. And we know we sound like a broken record, but the benefits of red wine are only beneficial when you drink in moderation! One standard (5 oz. of wine at 12% alcohol content) drink for women and two for men is generally considered to be safe. More than that, and youre doing more harm than good. But if youre down to drink responsibly and are looking for a few recommendations, these are our favorite American-made red wines to enjoy in 2020:

1Melville 2017 Estate Pinot Noir


Pinot Noirs have the highest levels of resveratrol, and Melvilles Pinot Noir is about as close to perfect as you can getand reasonably priced at $38. Made at its Rita Hills estate and aged in French oak barrels, it features a complex, fruit-forward aromatic blend of pomegranate, rhubarb, tangerine zest, and cherries. Its balanced, fresh, and vibrant.

2Cuvaison 2017 Estate Pinot Noir


This wouldnt be a wine list without a selection from Napa Valley, and from there we have to go with Cuvaison, a family-owned winery founded in 1969. Its Estate Pinot Noir is a little pricier than our Melville pick, at $42 a bottle, but for a special occasion its worth it. Youll find the aromas of rose petals, strawberries, and plumsand dark fruits on the palatehard to resist.

3Scribe 2018 Carneros Pinot Noir


While Napa is the most famous part of California wine country, I secretly prefer Sonoma (at least to visit!). My favorite wine there is Scribe, founded by two brothers in 2007. This 2018 Pinot Noir blend came with its return to normal after the 2017 North Bay fires and the years of drought that preceded them. Here, youll get spice from Martini grapes rounded out by the earthiness in Pommard grapes.

4La Crema 2018 Monterey Pinot Noir


Big Little Lies fans will love La Crema, a winery partially based in Monterey, where the popular show is filmed. Its 2018 Pinot Noir is reasonably priced at $28 and features flavors of plums, cranberries, and raspberries. The winemakers highlight its distinct minerality and notes of barrel spice.

52017 Justin Right Angle


Another wine-making area I love in California is Paso Robles, and there my favorite is Justin. A good go-to is the 2017 Right Angle, a unique, full-bodied blend of cabernet, petite verdot, petit sirah, and malbec. Youll taste ripe black fruit, vanilla, and oak upon your first sip. Its affordable too, at $28 a bottle if you're a wine society member (and it's free to sign up).

6Cooper Mountain 2017 Pinot Noir


Now were moving north, to the Willamette Valley in Oregon, where good wine often comes a little cheaper than in trendy California. One favorite is Cooper Mountain, which is organically grown and biodynamic. Its signature (and most affordable, at $28 a bottle) Pinot Noir is sourced from its three oldest estate vineyards and bursts with forest floor fruitblackberries, raspberries, and blueberries.

7Willamette Valley Vineyards 2018 Whole Cluster Pinot Noir


Even more economical at around $24 a bottle, Willamette Valley Vineyardss Whole Cluster Pinot Noir is certified sustainable and incredibly versatile. The winemakers call it liquid fruit salad in a glass because it opens with aromas of ripe black cherry, strawberry, black currant, and raspberry. Itll go perfectly with any BBQ dish this summer.

8Montinore 2017 Red Cap Pinot Noir


Montinore Estate is the largest producer of certified estate wines made from biodynamic grapes in the country (and its family-runKristin Marchesi manages the estate with her father!). Pinot Noirs are their specialty, and the 2017 Red Cap comes in at a great price point, just $24 a bottle. It's medium-bodied and has cherries, plum, and "a kiss of chocolate"on the palate.

9Bryn Mawr 2015 Tempranillo


Yes, finally! A red that isnt Pinot Noir! I love Bryn Mawr vineyards in Salem, OR, because the winemaker and vineyard director is a woman, Rachel Rose. One of her speciality wines, the 2015 Tempranillo, is outstanding. Youll have to pay for it, at $50 a bottle, but thats because this blend ages in barrels for at least two years and then bottles for at least one prior to release, which allows the tannins to soften and flavors to concentrate.

10Left Coast White Pinot Noir

Now heres something coola blend that combines the beauty of a Pinot Noir with the brightness and acidity of a white wine. This started out as an experiment at Left Coast and is now one of its most popular varietals. Pure Pinot Noir juice is fermented in stainless steel, then aged on the lees. Youll taste honeysuckle, pear, peach, and pineapple with a smooth, refreshing finish.

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Global trade impact of the Coronavirus Resveratrol Market Augmented Expansion to Be Registered by 2019-2028 – 3rd Watch News

Posted: May 28, 2020 at 11:48 am

A recent market study on the global Resveratrol market reveals that the global Resveratrol market is expected to reach a value of ~US$ XX by the end of 2029 growing at a CAGR of ~XX% during the forecast period (2019-2029).

The Resveratrol market study includes a thorough analysis of the overall competitive landscape and the company profiles of leading market players involved in the global Resveratrol market. Further, the presented study offers accurate insights pertaining to the different segments of the global Resveratrol market such as the market share, value, revenue, and how each segment is expected to fair post the COVID-19 pandemic.

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The following doubts are addressed in the market report:

Key Highlights of the Resveratrol Market Report

The presented report segregates the Resveratrol market into different segments to ensure the readers gain a complete understanding of the different aspects of the Resveratrol market.

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Competitive Outlook

This section of the report throws light on the recent mergers, collaborations, partnerships, and research and development activities within the Resveratrol market on a global scale. Further, a detailed assessment of the pricing, marketing, and product development strategies adopted by leading market players is included in the Resveratrol market report.

Sales and Pricing AnalysesReaders are provided with deeper sales analysis and pricing analysis for the global Resveratrol market. As part of sales analysis, the report offers accurate statistics and figures for sales and revenue by region, by each type segment for the period 2015-2026.In the pricing analysis section of the report, readers are provided with validated statistics and figures for the price by players and price by region for the period 2015-2020 and price by each type segment for the period 2015-2020.Regional and Country-level AnalysisThe report offers an exhaustive geographical analysis of the global Resveratrol market, covering important regions, viz, North America, Europe, China and Japan. It also covers key countries (regions), viz, U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam, Mexico, Brazil, Turkey, Saudi Arabia, UAE, etc.The report includes country-wise and region-wise market size for the period 2015-2026. It also includes market size and forecast by each application segment in terms of sales for the period 2015-2026.Competition AnalysisIn the competitive analysis section of the report, leading as well as prominent players of the global Resveratrol market are broadly studied on the basis of key factors. The report offers comprehensive analysis and accurate statistics on sales by the player for the period 2015-2020. It also offers detailed analysis supported by reliable statistics on price and revenue (global level) by player for the period 2015-2020.On the whole, the report proves to be an effective tool that players can use to gain a competitive edge over their competitors and ensure lasting success in the global Resveratrol market. All of the findings, data, and information provided in the report are validated and revalidated with the help of trustworthy sources. The analysts who have authored the report took a unique and industry-best research and analysis approach for an in-depth study of the global Resveratrol market.The following manufacturers are covered in this report:DSMEvolvaSabinsaInterHealthMayproLaurus LabsJF-NATURALGreat Forest BiomedicalShaanxi Ciyuan BiotechChengdu YazhongChangsha Huir Biological-techXian Gaoyuan Bio-ChemXian SinuoteResveratrol Breakdown Data by TypeSyntheticPlant ExtractFermentationResveratrol Breakdown Data by ApplicationDietary SupplementCosmeticFood and BeverageOthers

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Global trade impact of the Coronavirus Resveratrol Market Augmented Expansion to Be Registered by 2019-2028 - 3rd Watch News

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Heading off aging with functional ingredients – Natural Products INSIDER

Posted: May 28, 2020 at 11:48 am

Its no secretpeople around the world are living longer. But as the marketplace of products targeted at the healthy aging segment matures, ingredient suppliers and manufacturers of cosmeceuticals with functional components are homing in on consumers desire for products that can add to the quality, and not simply the quantity, of their lives.

Pressed oils rich in fatty acids, plant sterols and natural antioxidants. Pure aloe, formulated for topicals or trendy ingestible delivery formats, and laden with polysaccharides with proven effects on overall health and wellness. A ribose-vitamin compound that can help negate factors associated with skin aging. Resveratrol, collagen and keratin formulated for both topical and ingestible deliveries, carrying the promise of youthful beauty, both inside and out.

These types of functional ingredientsapplied across myriad delivery formats including serums, creams, moisturizers, dietary supplements, and even foods and beveragesattract product makers looking to capture a piece of the burgeoning global population of folks 60 or older, which totaled 987 million in 2017 and is expected to double by 2050, according to the United Nations report, World Population Prospects.

Nutraceuticals are emerging as a class of functional ingredients with specific application to the healthy aging segment, as health benefits derived from food sources beyond their nutritive value are beginning to be more completely understood.

Deficiencies in vitamins E, B6 and B9 (folate), and the minerals zinc and selenium are particularly common, according to Zeeshan Sirkhot, media team member with Persistence Market Research, and deficits of these micronutrients have been reported to negatively influence immunity.14 Nutraceutical products can improve micronutrient status, and the regular use of nutraceuticals by the elderly may provide an opportunity to enhance immunity.

To read this article in its entirety, check out the Healthy aging: Outward vitality digital magazine.

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Heading off aging with functional ingredients - Natural Products INSIDER

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Global Resveratrol Market Research with COVID-19 Impact on Growth, Latest Trend Analysis and Forecast 2025 – NJ MMA News

Posted: May 28, 2020 at 11:48 am

GlobalResveratrolMarket Report 2020, Forecast to 2025studies market status and outlook from the view of players, countries, product types, and end industries. The report offers an industry overview covering insightful data on market growth, historical & futuristic cost, revenue, demand, and supply data (as applicable). The report analyzes the top players in the globalResveratrolmarket and splits the market by product type and applications/end industries. The report presents comprehensive data that enhances the understanding, scope, and application of this report. The report also explores the current outlook in global and key regions from the perspective of players, countries, product types, and end industries.

A comprehensive analysis of the competitive manufacturers, as well as the new entrants, is given along with their brief research. The report presents an in-depth analysis of the opportunities and challenges faced by the leading service provides. This report is specially designed to know accurate market insights and market status. The report studies contestant performance of the globalResveratrolmarket. Total sales of each product, as well as the net profit accumulated by the product segments over the analysis period, are entailed in the report. Furthermore, the report encompasses details regarding the market share attained by these application segments along with their potential and consumption volume during the study period from 2015 to 2025.

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NOTE: Our analysts monitoring the situation across the globe explains that the market will generate remunerative prospects for producers post COVID-19 crisis. The report aims to provide an additional illustration of the latest scenario, economic slowdown, and COVID-19 impact on the overall industry.

Competitive Outlook:

This report throws light on the recent mergers, collaborations, partnerships, and research and development activities within the globalResveratrolmarket on a global scale. Further, a detailed assessment of the pricing, marketing, and product development strategies adopted by leading market players is included in the market report. The market share, product portfolio, pricing strategy, and growth strategies adopted by each market player is included in the report. Additionally, the major steps taken by key players to address the business challenges put forward are discussed in the report.

We provide a detailed analysis of key players operating in the globalResveratrolmarket:DSM, Evolva, Sabinsa, InterHealth, Maypro, Laurus Labs, JF-NATURAL, Great Forest Biomedical, Shaanxi Ciyuan Biotech, Chengdu Yazhong, Changsha Huir Biological-tech

Segment by regions, the report covers:North America (United States, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, Colombia etc.), Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

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Research Methodology:

Moreover, the report includes primary and secondary data which is demonstrated in the form of pie outlines, tables, analytical figures, and reference diagrams. Researchers of this report have opted for a bottom-up and top-down approach. The bottom-up approach gives access to the numbers for each product, and the top-down approach helps in counter-validating those numbers with end-use market numbers. The key figures are determined along with examples as per need which will help in creating clear knowledge about the globalResveratrolmarket during the forecast period from 2020 to 2025.

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Global Resveratrol Market Research with COVID-19 Impact on Growth, Latest Trend Analysis and Forecast 2025 - NJ MMA News

Recommendation and review posted by G. Smith

Why red wine is actually good for your health – AOL

Posted: May 28, 2020 at 11:48 am

Food Flashexplores the wild world of food news, from the health benefits of red wine to why dark chocolate is actually good for you.

After a long day when everything seems to be going wrong, theres nothing better than curling up with a glass of red wine.

Relaxing with a heavy pour can soothe the pain of work drama and trouble in your personal life. But did you know its actually good for your health?

Heres how a glass of red wine every day can keep the doctor away:

1. Improves oral hygiene

Scientists found that polyphenols, antioxidants found in red wine, can prevent cavities and plaque and fight gum disease.

2. Improves heart health

The delicious drink has been shown to reduce blood clots and boost the healthy cholesterol known as HDL, according to the Mayo Clinic.

3. Helps regulate blood sugar

Good news for anyone struggling with diabetes: The skin of red grapes actually helps keep your blood sugar levels in check, according to researchers.

4. Makes you smarter (in a way)

Doctors say red wine can actually boost your brainpower. Resveratrol, a chemical found in red grapes, has been shown to sharpen memory. Studies have also shown that it may help prevent Alzheimers and dementia.

Lets raise our glasses to the many health benefits of red wine.

If you enjoyed this story, you might also like reading about how to host a wine and cheese tasting at home.

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