The Future Of Nano Technology
- Alan Watts
- Anti-Aging Medicine
- David Sinclair
- Gene Medicine
- Gene therapy
- Genetic Medicine
- Genetic Therapy
- Global News Feed
- Hormone Replacement Therapy
- Human Genetic Engineering
- Human Reproduction
- Integrative Medicine
- Life Skills
- Longevity Medicine
- Machine Learning
- Medical School
- Nano Medicine
- Parkinson's disease
- Quantum Computing
- Regenerative Medicine
- Stem Cell Therapy
- Stem Cells
- NeuBase Therapeutics Reports Financial Results for the Second Quarter of Fiscal Year 2021 – GlobeNewswire
- NeuBase Therapeutics Appoints Gerald J. McDougall to Board of Directors – BioSpace
- Biogen looks to build better gene therapies through latest deal – BioPharma Dive
- From one genomic diagnosis, researchers discover other treatable health conditions – National Human Genome Research Institute
- Gene and Cell Therapy Breakthroughs Focus of World Medical – GlobeNewswire
- vagina innie outie comparison
- jackson avery and aprils child
- jackson and aprils daughters name
- the numbness not going away after teeth extraction
- innie vs outie labia
- greys anatomy ortiz
- dr ortiz greys anatomy
- jaw numbnesd after a tooth extraction
- greys anatomy cast dr ortiz
- mother daughter interna on greys amatomy
|Search Immortality Topics:|
Category Archives: Anti-Aging Medicine
Global Energy-Based Therapeutics Market 2020 Disclosing Latest Trends and Advancement Outlook 2026 Along With Covid-19 Impact Analysis KSU | The…
DBMR has added a new report titled Global Energy-Based Therapeutics Market with analysis provides the insights which bring marketplace clearly into the focus and thus help organizations make better decisions. This report covers the present scenario and the growth prospects of the global market and includes a discussion of the key vendors operating in the market. It intends to supply an entire 360-degree perspective of this market concerning cutting edge technology, key advancement, drivers and restraints and prospective trends with impact analysis. This study also analyzes the market status, market share, growth rate, future trends, market drivers, opportunities and challenges, risk and entry barriers. This Global Energy-Based Therapeutics Market report presents the market competitive landscape and a corresponding detailed analysis of the major vendor/key players in the market.
This Global Energy-Based Therapeutics Market report provides a valuable source of insightful for business strategists and competitive analysis of the global market. It provides industry overview with the growth analysis and futuristic cost. This Global Energy-Based Therapeutics Market research report guides you to overcome the upcoming obstacles in the business. Various Analytic tools like SWOT analysis, Porters five force analysis, PESTLE Analysis are utilized to gain the relevant information of the market. In the end, Report provides a comprehensive data which enhances the understanding, scope and application of the report.
Global Energy-Based Therapeutics Market, By Product Type (Microwave, Radiofrequency, Hydro-Mechanical, Cryotherapy, Thermal and Ultrasound), Clinical Application (Aesthetic, Surgical and Ophthalmic), End-User (Hospital, Clinics and Others), Country (U.S., Canada, Mexico, Germany, Italy, U.K., France, Spain, Netherland, Belgium, Switzerland, Turkey, Russia, Rest of Europe, Japan, China, India, South Korea, Australia, Singapore, Malaysia, Thailand, Indonesia, Philippines, Rest of Asia- Pacific, Brazil, Argentina, Rest of South America, South Africa, Saudi Arabia, UAE, Egypt, Israel, Rest of Middle East & Africa) Industry Trends and Forecast to 2027
Market Analysis and Insights : Global Energy-Based Therapeutics Market
Energy-based therapeutics market is expected to gain market growth in the forecast period of 2020 to 2027. Data Bridge Market Research analyses the market to account to grow at a CAGR of 6.00% in the above-mentioned forecast period. Invent of laser based therapies insurgicalprocedures will drive the growth of the market.
Download Exclusive Sample Report (350 Pages PDF with All Related Graphs & Charts) @https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-energy-based-therapeutics-market&pm
The major players covered in the energy-based therapeutics market report are Johnson and Johnson Surgical Vision, Inc, AngioDynamics, Inc, Alna-Medicalsystem AG and Co.KG, Alcon Management S.A, AtriCure,Inc, Symmetry Surgical, Boston Scientific Corporation, biolitec AG, Cutera, Inc, Cynosure, Dornier MedTech, INSIGHTEC Ltd, EDAP TMS, IRIDEX Corporation, LIGHTMED, Mederi Therapeutics Inc, Medtronic plc, NIDEk CO,LTD, Optos plc.UWF, among other domestic and global players.
Competitive Landscapeand Global Energy-Based Therapeutics Market Share Analysis
Energy-based therapeutics market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies focus related energy-based therapeutics market.
Energy-based therapeutics are done for the destruction and modification of tissues with the help of technologies such as hydro-mechanical, cryotherapy, ultrasound, microwave and thermal.
In aesthetic medicine have led to an increase in the adoption of anti-aging treatments and energy-based aesthetic surgeries, energy-based therapeutics are affordable and effective and shift of invasive to non-invasive aesthetic procedures on global level due to this reason has driven the growth of the market. Increased number of population for minimal invasive surgeries for the treatment of cancer, tumors, cardiac arrhythmias and other diseases with the benefits associated with these procedures such as creating a positive outlook and reduced complications for the global energy based therapeutic market are factors driving the growth of the market. Rising trend of physician owned ambulatory surgical centres known as ASCs is a key factor for the growth of the market and will create growth opportunities in energy-based therapeutics market the forecast period of 2020-2027.
Varied regulations for medical devices will act as a restrain, and further challenges the growth of energy-based therapeutics market forecast period mentioned above.
This energy-based therapeutics market report provides details of new recent developments, trade regulations, import export analysis, production analysis, value chain optimization, market share, impact of domestic and localised market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, strategic market growth analysis, market size, category market growths, application niches and dominance, product approvals, product launches, geographic expansions, technological innovations in the market. To gain more info on Data Bridge Market Research energy-based therapeutics market contact us for anAnalyst Brief, our team will help you take an informed market decision to achieve market growth.
Global Energy-Based Therapeutics Market Scope and Market Size
Energy-based therapeutics market is segmented on the basis of clinical application, end-user and product type. The growth amongst these segments will help you analyse meagre growth segments in the industries, and provide the users with valuable market overview and market insights to help them in making strategic decisions for identification of core market applications.
Table of Contents-Snapshot
Executive SummaryChapter 1 Industry OverviewChapter 2 Industry Competition by ManufacturersChapter 3 Industry Production Market Share by RegionsChapter 4 Industry Consumption by RegionsChapter 5 Industry Production, Revenue, Price Trend by TypeChapter 6 Industry Analysis by ApplicationsChapter 7 Company Profiles and Key Figures in Industry BusinessChapter 8 Industry Manufacturing Cost AnalysisChapter 9 Marketing Channel, Distributors and CustomersChapter 10 Market DynamicsChapter 11 Industry ForecastChapter 12 Research Findings and ConclusionChapter 13 Methodology and Data Source
For More Insights Get FREE Detailed TOC @https://www.databridgemarketresearch.com/toc/?dbmr=global-energy-based-therapeutics-market&pm
Global Energy-Based Therapeutics Market Country Level Analysis
Energy-based therapeutics market is analysed and market size insights and trends are provided by country, clinical application, end-user and product type as referenced above.
The countries covered in the energy-based therapeutics market report are U.S., Canada and Mexico in North America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA), Brazil, Argentina and Rest of South America as part of South America.
North America is dominating the energy-based therapeutics market due to its well established healthcare infrastructure. As growing preference for minimally invasive surgeries in this region are responsible for the growth of the market in the region.
The country section of the energy-based therapeutics market report also provides individual market impacting factors and changes in regulation in the market domestically that impacts the current and future trends of the market. Data points such as consumption volumes, production sites and volumes, import export analysis, price trend analysis, cost of raw materials, down-stream and upstream value chain analysis are some of the major pointers used to forecast the market scenario for individual countries. Also, presence and availability of global brands and their challenges faced due to large or scarce competition from local and domestic brands, impact of domestic tariffs and trade routes are considered while providing forecast analysis of the country data.
Healthcare Infrastructure growth Installed base and New Technology Penetration
Energy-based therapeutics market also provides you with detailed market analysis for every country growth in healthcare expenditure for capital equipments, installed base of different kind of products for energy-based therapeutics market, impact of technology using life line curves and changes in healthcare regulatory scenarios and their impact on the energy-based therapeutics market. The data is available for historic period 2010 to 2018.
About Data Bridge Market Research:
An absolute way to forecast what future holds is to comprehend the trend today!Data Bridge set forth itself as an unconventional and neoteric Market research and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best market opportunities and foster efficient information for your business to thrive in the market. Data Bridge endeavors to provide appropriate solutions to the complex business challenges and initiates an effortless decision-making process.
Data Bridge Market Research
US: +1 888 387 2818
UK: +44 208 089 1725
Hong Kong: +852 8192 7475
GNT Pharma’s GedaCure Approved for the Treatment of Dogs With Cognitive Dysfunction Syndrome – Business Wire
YONGIN, South Korea--(BUSINESS WIRE)--GNT Pharma today announced the Korea Animal and Plant Quarantine Agency (APQA) has approved the New Drug Application for GedaCure, a chewable tablet of crisdesalazine, for the treatment of dogs with cognitive dysfunction syndrome (CDS) that suffer from disorientation, altered interactions with family, sleep-wake cycle disturbance, house soiling and changes in activity with aging.
GedaCure is the worlds first multi-target neuroprotection drug for canine cognitive dysfunction syndrome. It is expected to improve the quality of life of aged dogs with CDS and their owners. GNT Pharma plans to launch GedaCure in South Korea and will push ahead in earnest to advance globally for dogs and their family who suffer from CDS.
Like Alzheimers disease (AD), canine CDS is an age-related progressive neurodegenerative disease with a cognitive and behavioral deficit that is accompanied by beta amyloid precipitation, pathological tau, and neuronal death. The prevalence of senior dogs with CDS has been rapidly increasing with the extended lifespan, however, there is no cure for the disease.
Crisdesalazine prevents oxidative stress as a spin trapping agent and inflammation as an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), inducible enzymes essential for inflammatory PGE2 production. Crisdesalazine showed considerable effects in 3-D culture and animal models of Alzheimers disease in reducing neuronal death, tauopathy, and amyloid plaques to some extent which are pathological hallmarks of Alzheimers disease.
In a pilot clinical trial for canine CDS, all 6 companion dogs with CDS that received daily oral administration of 10 mg/kg crisdesalazine for 8 weeks showed remarkable symptomatic relief. Even in 4 weeks after administration of crisdesalazine, the dogs re-recognized and wagged their tails to their owners, slept well in the night, and revealed improved activity.
GNT Pharma conducted a double-blind, randomized, placebo-controlled phase III SMART trial of crisdesalazine for 48 companion dogs with CDS at 6 animal hospitals including Seoul National University Animal Hospital. All dogs were diagnosed as CDS according to canine cognitive dysfunction rating scale (CCDR score: 0-39 = normal, 40-49 = at risk, 50-80 = CDS). Baseline scores of CCDR before drug treatment were 61.7 2.8 for the placebo group and 62.2 2.3 for the crisdesalazine group. CCDR scores were 60.7 2.7 and 65.0 3.9 after 4-week and 8-week treatment with placebo. CCDR scores were reduced to 43.0 2.9 and 42.1 4.0 after 4-week and 8-week treatment with 5 mg/kg crisdesalazine, demonstrating significant beneficial effects of crisdesalazine vs placebo (p<0.0001). Similar beneficial effects were observed in companion dogs with CDS treated with 10 mg/kg crisdesalazine. Such beneficial effects lasted over at least 4 weeks after discontinuing 8-week treatment with crisdesalazine. Drug-related adverse events were not observed.
Administration of crisdesalazine significantly and noticeably improved cognitive function and behavioral activity without causing adverse effects in dogs with CDS that participated in the SMART trial. With rapidly increasing population of aged dogs, CCDS has been one of therapeutic areas with the highest unmet medical need. In light of proven efficacy and safety, crisdesalazine is expected to improve the quality of life of aged dogs with CDS and their owners, said Hwa-Young Youn, D.V.M. and Ph.D., Professor of Veterinary Medicine at Seoul National University, Principal Investigator of SMART trial.
We are excited to receive a new drug approval for the treatment of old dogs with CDS. The novel dual antioxidant and anti-inflammatory action of crisdesalazine, which was shown to reduce amyloid plaque, tauopathy, and neurodegeneration in various cell culture and animal models, has the potential to revolutionize how we care for CDS, said Byoung Joo Gwag, Ph.D., GNT Pharmas President and CEO, Adjunct Professor of Biological Sciences at Yonsei University. Crisdesalazine, the first multi-target drug proven and approved for CDS featuring brain pathology similar to AD, gives hope for better treatment of AD patients. We plan to initiate a pivotal clinical trial of crisdesalazine for patients with mild to moderate AD this year.
Eat This, Not That!
Sugar is hard to escape in the American diet. It's in everything from condiments to juices to bread. And yes, even in those McDonald's fries. And Americans are eating a lot of it."Today, the average American consumes almost 17 teaspoons of added sugar a day, according to researchers at the University of California San Francisco," says Sue Heikkinen, MS, RD, registered dietitian for MyNetDiary. One in four Americans far exceeds the USDA's recommended daily added sugar cap of 50 grams, instead consuming a staggering 105 grams of added sugar per day. (The American Heart Association guidelines suggest no more than 24 grams of added sugar for women and no more than 35 grams for men.)Most of that sugar comes from drinks. "Sugar-sweetened beverages, such as soda, energy drinks, and sweetened tea are the leading source of added sugarproviding 47% of added sugar in the U.S. diet," says Heikkinen. "There is some encouraging newsthis added sugar intake represents a decrease from earlier reports."Eat a diet high in sugar, and the impact may not be seen until later."Many of the side effects of excess sugar consumption aren't immediate, but instead build up over years," says Elizabeth Spencer, MS, RDN, LDN, registered dietitian at Northwestern Medicine Central DuPage Hospital. "These include risk of Type 2 diabetes, fatty liver, heart disease, and inflammation of the joints."Excessive intake of added sugar can lead to various health issues such as weight gain, inflammation, and diabetes, so you'll want to look out for the signs you're overdoing it before it gets any worse.One of the biggest danger signs that you're eating too much sugar is that you're constantly feeling both anxious and tired.Sugar is our body's main source of energy, so it's somewhat ironic that eating too much of the stuff can cause us to feel tired. "Eating sugary foods can indeed give an energy boost, but it can result in a crash later," says Heikkinen. "This can set up a vicious cycle of turning to sugar again for a quick energy, then feeling fatigued again later. Fatigue can also be a symptom of high blood sugar (caused by eating too much sugar)."Spencer explains that eating too much sugar at one time can cause jiteriness, but the fatigue will come quickly afterwards. "Eating a high sugar food can raise the amount of sugar in our bloodstream very quickly and provide a quick burst of energy, as well as feelings of anxiety and jitteriness," says Spencer. "When we have an excess amount of sugar in our bloodstream, our body rapidly produces the hormone insulin to usher the sugar into our cells. This can then cause a sugar crash from decreased sugar in our bloodstream, resulting in that midafternoon slump and low energy."This crashing sensation won't just drain your energy at certain times of the day, it may even go so far as to disrupt a good night's sleep."Consuming large amounts of sugar is linked to lower quality sleep," says Spencer. "In a clinical trial evaluating sugar's impact on sleep, those who consumed significant amounts of sugar had less time in deep, restorative slow-wave sleep. Those who ate more sugar also took longer to fall asleep."How can you fit sugar into a healthy diet?You don't need to totally forbid yourself from sugar."Although there are health risks of excess sugar, it is by no means a poison," says Heikkinen.In fact, totally cutting out sugar or forbidding yourself from having your favorite sweet treat may make you crave it even more, making it harder to control the portion when you do eat it."If you can limit sneaky sources of added sugar such as cereals, salad dressings, and granola bars, you can leave room in your budget for foods you really enjoy, such as a piece of chocolate," says Heikkinen.Aim for added sugar in moderation combined with mindful eating habits."Having sugary food every once in a while is okay! Moderation is key here. Zoom out to the big picture of your dietary habits, and look at 'how much and how often' are you having a sugar-sweetened food," says Spencer.She recommends a few easy ways to moderate your sugar intake.Read nutrition labels and keep sugar at less than 6 grams of added sugar per one serving of a packaged food item (this excludes fruit and plain dairy products).Pair foods with added sugar with protein, fat, and fiber to slow down digestion and enhance satiety. An example would be pairing a serving of sweetened granola with plain Greek yogurt and fiber-packed berries.And if you are struggling to manage sugar intake or feel out of control with sugar, another recommendation is to connect with a registered dietitian who can help you incorporate sugar in a healthful way. For help, check out these 20 Ways to End Sugar Cravings For Good, According to Nutritionists.For more healthy eating news, make sure to sign up for our newsletter!
Read this article:
In The Know Honors: Shereen Pimentel - Yahoo Canada Shine On
BEIJING, Jan. 8 (Xinhua) -- For the first time, a genome-wide CRISPR-based screening technology has identified a new driver of cellular senescence. It can form part of new strategies to delay aging and prevent aging-associated diseases, Chinese researchers said.
By screening and identifying more than 100 genes responsible for the aging of human cells, the research team demonstrated that knocking out, or disabling, some genes by CRISPR can discourage the aging of human mesenchymal precursor cells (hMPCs). Among the genes that lead to senility, and KAT7 (a histone acetyltransferase), is one of the catalysts for aging.
Knocking out KAT7 has been proven effective in alleviating cellular senescence in the team's experiments, said Zhang Weiqi, a researcher at the Beijing Institute of Genomics under the Chinese Academy of Sciences. The scientists managed to reduce the proportion of the senescent cells in the livers of aged mice and prolonged the lifespan of physiologically aged mice and those with progeria.
The novel gene therapy, based on disabling a single gene or using KAT7 inhibitors, could extend mammal life. It could also slow down the aging of human liver cells. It suggests a massive potential for its application in translational medicine against human aging.
The study was published on Thursday in Science Translational Medicine online.
Global Medical Aesthetics Market Overview By Size, Share, Trends, Growth Factors and Leading Players With Detailed Analysis of Industry Structure -…
DBMR has added a new report titled Global Medical Aesthetics Market with analysis provides the insights which bring marketplace clearly into the focus and thus help organizations make better decisions. This Global Medical Aesthetics Market research report understands the current and future of the market in both developed and emerging markets. The report assists in realigning the business strategies by highlighting the business priorities. It throws light on the segment expected to dominate the industry and market. It forecast the regions expected to witness the fastest growth. This report is a collection of pragmatic information, quantitative and qualitative estimation by industry experts, the contribution from industry across the value chain. Furthermore, the report also provides the qualitative results of diverse market factors on its geographies and Segments.
Global medical aesthetics market is projected to register a healthy CAGR of 12.1% in the forecast period of 2019 to 2026.
Get Sample Report + All Related Graphs & Charts @https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-medical-aesthetics-market
Aesthetics devices are an innovative advancement, providing a solution to patients which deal with the ingenuity of creating beauty. The medical aesthetics devices is a growing market owing to its benefits such as maintaining the youthful appearance, pain free and non-invasive beauty treatments, maintenance free skin that remains smooth and hairless without the need for shaving, waxing or unpleasant hair treatments, improving the cosmetic appearance, and technological advancement in medical aesthetics devices.
The market is showing a substantial growth in the emerging countries as these countries are adapting to the trends of urbanization. Brazil, South Africa, Thailand and many others have improved in the past one decade. People are opting different aesthetics surgeries to maintain themselves, which give them better results without any stressful physical efforts. Medical Aesthetics is one of the most trending concepts of the 21stCentury which will show a substantial increase in the future as there is a great technological advancement and innovation in the field by the companies dealing with these devices making them safer and even less invasive leading to more population opting for these procedures.
Competitive Analysis: Global Medical Aesthetics Market
Some of the major players operating in the global medical aesthetics market are Allergan, Bausch Health Companies Inc., Lumenis, Shanghai Fosun Pharmaceutical Group Co. Ltd., Cynosure, Syneron Medical Ltd, Aerolase Corp., A.R.C. Laser Gmbh, Asclepion Laser Technologies Gmbh, Btl, Cutera, Eclipse, Lutronic, Mentor Worldwide Llc, Merz Pharma, Quanta System, Sciton Inc., Sharplight Technologies Inc, Syneron Medical Ltd., Venus Concept.
Segmentation: Global Medical Aesthetics Market
Global medical aesthetics market is segmented into 4 notable segments such as product type, type of care, accessories and end user
Grab Your Report at an Impressive 30% Discount! Please click Here@
The company was founded in 2013 and headquartered at Dublin, Ireland. The company is focused on developing, manufacturing and commercializing branded device, biologic, pharmaceutical, surgical and regenerative medicine products for patients throughout the world. The main business segments are US Specialized Therapeutics, US General Medicine, International. The revenue of the company in healthcare sector 2018 was USD 16,550.8 Million. The company has global presence in North America, Asia Pacific, South America, Europe and Middle East & Africa.
Access Full Report athttps://databridgemarketresearch.com/reports/global-medical-aesthetics-market/
Bausch Health Companies Inc.
The company was founded in 1959 and headquartered at Quebec, Canada. The company is engaged in manufacturing and marketing a broad range of branded and generic pharmaceuticals, over-the-counter (OTC) products and medical devices. The main business segments are Bausch + Lomb/International, Branded Rx, U.S. Diversified Products. The revenue of the company in healthcare sector 2018 was USD 8,174.8 Million. The company has global presence in North America, Europe, the Middle East, Africa, Asia Pacific and Latin America.
The company was founded in 1991; headquarter in Yokeneam, Israel. The company is engaged in the field of minimally-invasive clinical solutions for the Surgical, Ophthalmology and Aesthetic markets, and expert in developing and commercializing innovative energy-based technologies, including Laser, Intense Pulsed Light (IPL) and Radio-Frequency (RF). The company has global presence in North America, South America, Europe, Asia, Africa and Australia.
Note: If you have any special requirements, please let us know and we will offer you the report as you want.
About Data Bridge Market Research:
Data Bridge Market Research set forth itself as an unconventional and neoteric Market research and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best market opportunities and foster efficient information for your business to thrive in the market. Data Bridge endeavors to provide appropriate solutions to the complex business challenges and initiates an effortless decision-making process.
Data Bridge Market Research
US: +1 888 387 2818
UK: +44 208 089 1725
Hong Kong: +852 8192 7475
Its an undeniable truth that aging is inevitable. Isnt it? What if almost everything weve been taught about aging is wrong? What if we could change how long we live? In other words, could we choose our longevity by having better healthspan?
Statistics show that the age of our community is rising, especially in the developed world. In 2017, one in eight people worldwide was aged 60 and over. In 2050, older people are projected to account for one in five people globally. So, by 2050, this group will be around two billion people.
The most rapid increase in the 60+ population is occurring in the developing world. It is expected to show a 225% jump between 2010 and 2050.
In our youth, the issue of aging wasnt something we lost sleepover. Our energy levels could withstand anything. We woke up feeling fresh and ready to take on the day. We even indulged in a double-cheese pizza didnt result in our picking up a very resistant 3kg, seemingly overnight.
However, over time, the reality of aging kicks in. Now, science reveals that our lifespan will be determined 70% by our lifestyle and 30% by genetics.
Scientists such as Australian-born David Sinclair, a leading researcher in the field of aging at Harvard Medical School in the US, believes youthfulness can also be reset in the body, using epigenetic reprogramming. He says: Soon we will be able to tweak cells in a particular way that the central nervous system behaves as if it were young again. This is an exciting moment in time for the science of longevity. Researchers are on the verge of understanding the process of aging and how to create drugs that promote extended healthy longevity.
Lifespan refers to how long a person lives, from birth to death. Healthspan, on the other hand, is about how many of those years were lived in complete health. It describes how long we are able to function without the assistance of others, in the absence of chronic disease and frailty.
Dr. Craige Golding, a specialist physician and pioneer of aging medicine in South Africa explains: I always say to my patients, if theyre going to get older, they not only want the absence of diseases like cancer, dementia, Alzheimers, but they also want to have good mobility, good vision, and good memory. [Integrative medicine is about] incorporating many modalities, not just fighting to age. Its about looking at the person holistically, not just treating a diagnosis.
More often than not, a patient is labeled with a diagnosis, given a bunch of pharmaceuticals, and sent home. However, in holistic or integrative medicine, we look at the person as a whole. How is their diet? How is their lifestyle? Are they exercising? Are they sleeping well and managing their stress levels? What supplements are they taking? With lifestyle and supplement changes, one can often reverse these kinds of chronic conditions. Thats where my passion grew for integrative medicine because as a physician in private practice, I realized that I wasnt helping my patients with chronic diseases enough.
There are so many associated diseases when it comes to aging, he explains. When you combat these mechanisms and understand them, you can prevent many diseases.
Like Sinclair, Golding believes that by positively engaging with your health and beauty, incorporating time-honored and science-based wellness practices, and understanding how to combat aging with these practices, you can actively lengthen and improve your healthspan, and influence how you age.
Aging is a series of multiple processes. These processes include:
These processes result in the familiar signs of aging and ultimately to the development of age-related diseases that eventually kill us.
Combining analysis of cutting-edge scientific findings with our deepest ancestral wisdom and health-promoting practices, we can help to prevent and manage the most common health afflictions of our day: cancer, heart disease, neurodegenerative diseases, and metabolic syndrome. That way, if youre serious about really living well for long, you figure out which areas of your health need attention and how to work on those.
Today there are many tests that can be done to determine how healthy you really are and what lifestyle changes or supplements will make a difference. You have the option of assessing your hormones, seeing where you are in terms of stress levels, as well as testing your nutrigenomics, inflammation markers, glycation markers, detox markers, telomere markers, and methylation markers.
However, this can be a costly exercise, and deciding where to focus your attention can be tricky.
The easiest way to start is to look at the 10 primary mechanisms of aging and discuss your aging concerns, and the areas that need to be looked at, with your doctor. This will help you determine what can be done to intervene against these mechanisms.
Oxidative stress occurs when there is an imbalance of free radicals and antioxidants in the body. Examples of free radicals include hydroxyl radical, nitric oxide radical, and superoxide. This can be countered with good-quality antioxidants in the diet and supplements, as well as specific lifestyle changes.
Glycation takes place between reduced sugar and proteins, lipids and nucleic acids, wherein reactive carbonyl groups of a reducing sugar react with free amino groups of proteins to form an unstable Schiff base. Advanced glycation end products are formed through this reaction.
Telomeres are the caps at the end of chromosomes that protect the cells. These wear down as you age until they are so short that they cant protect your cells.
Golding explains that, in his practice, there is a test called a telomere link or teloyears. The longer the link, the younger you are biologically and the longer you will probably live.
So lets say youre 60 years old. Youre significantly overweight. You have early signs of Type-2 diabetes. Youre eating poorly, youre not exercising, and youre stressed out. Generally, in that scenario, your telomere length is going to be very short. This means your lifespan is probably going to be shortened significantly. Once your telomeres disappear, your cells can no longer divide. You enter a state called cellular kinesthesis, where you cant replicate your cells anymore. Thats one marker of what you can do to know your telomere length, and with lifestyle interventions such as proper diet, taking good supplements, sleep, exercise, and managing your stress, you can actually extend your telomere length, whatever your age. Your hormones, genes, social interactions all of these things play a role, and the lifestyle components are very important.
Astragalus membranaceus (AST) is a plant-based compound that demonstrates, in labs, immunomodulatory, antioxidative stress and anti-aging effects which are associated with extending longer telomeres, thus extending lifespan.
By the time one is middle-aged, levels of NAD+ (nicotinamide adenine dinucleotide) have fallen to 50%, with resulting loss of sirtuin and PARP activity.
PARP inhibitors are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP). They are developed for multiple indications, including the treatment of heritable cancers. Sirtuins are a family of histone deacetylases that seem to regulate oxidative stress and damage to DNA, as well as organismal lifespan. Compelling research shows that NAD+ has a unique ability to protect tissues, induce DNA repair, and increase lifespan. It has long been known that NAD+ plays an important role in transferring energy released from glucose and fatty acids to the mitochondria, so that it can be converted into cellular energy.
Recent studies have revealed that the decline in NAD+ levels causes aging-related disorders, and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models.
Nicotinamide mononucleotide (NMN) has been shown to mitigate many aging-related dysfunctions.
Senescent cell production occurs throughout life and plays beneficial roles in a variety of physiological and pathological processes. This includes embryogenesis, wound healing, host immunity, and tumor suppression.
Meanwhile, throughout life, the steady accumulation of senescent cells in the body with age also has an adverse consequence that leads to age-related death. Senescent cells dont divide or support the tissues of which they are part. Instead, they emit a range of potentially harmful chemical signals that encourage nearby cells to enter into the same senescent state.
Autophagy (the natural process in the body of removing damaged cells, and thereby regenerating newer ones) was originally thought to suppress cellular senescence by removing damaged macromolecules or organelles. Now, recent studies also indicate that autophagy promotes cellular senescence by facilitating the synthesis of senescence-associated secretory proteins. As a result, a different strategy to remove the accumulation of senescent cells is needed.
A new class of drugs, known as senolytics, focuses on the destruction of these stubborn death-resistant cells from the body to reduce inflammation and improve tissue function.
While scientists are looking for more powerful synthetic drugs, Golding incorporates two of the most powerful natural senolytics in his senescent cell removal program. These are fisetin and quercetin. Fisetin is a plant flavonoid found in fruits, mostly in strawberries. Quercetin is a flavonol pigment found in fruits and vegetables, with its highest concentration found in capers. It has antioxidant properties that work to protect the body from free radicals and oxidative stress and is considered to be a more powerful antioxidant than vitamin C, vitamin E or beta carotene.
Resveratrol is an everyday maintenance program against senescent cells. Its a known activator of SIRT1, which slows aging, and has been demonstrated to inhibit mTOR activity and cellular senescence.
Mammalian target of rapamycin (mTOR) is a signaling pathway heavily linked to the aging process.mTOR is stimulated by nutrients and growth factors, and inhibited by stress, to ensure that cells grow only during favorable conditions.
As with most healthspan-related advice, caloric restriction is advised. Fasting and a reduction of calorie intake is implicated with mTOR inhibition. The two most popular options are a small feeding window (four hours per day) or 24-hour fasts two to three times per week.
The SIRT1 gene is a multifunctional protein deacetylase that plays important roles in cellular pathways including longevity, metabolism, cellular senescence, genome maintenance, DNA repair, and inflammation. Thus, the loss of NAD+ has direct and indirect consequences on multiple cellular endpoints. Ultimately, depletion of intracellular NAD+ alters the NAD+/SIRT1 axis and leads to defects in mitochondrial homeostasis, ROS production, DNA repair, and cell survival.
It has consistently been shown that the loss of activity from the NAD+/SIRT1 axis also inhibits mitophagy (the selective degradation of mitochondria by autophagy).
Nicotinamide mononucleotide (NMN) and NR, a key NAD+ precursor intermediate which decreases with age in mammals, is an efficient therapy against age-associated diseases. Research has further demonstrated that NMN activates Sirtuin1 (SIRT1), which is a NAD enhancer.
Proteostasis is the concept that there are competing and integrated biological pathways within cells that control the biogenesis, folding, trafficking, and degradation of proteins present within and outside the cell. One of the results of a loss of NAD+ as a person gets older is a loss of proteostasis, causing havoc on the system.
Once again, NMN and/or NR is an efficient therapy against age-associated diseases, including loss of proteostasis.
Inflammation drives all diseases, and it can ignite a long list of disorders. This can includearthritis, asthma, atherosclerosis, blindness, cancer, diabetes, and, quite possibly, autism and mental illness.
In clinical practice, we can do a simple test, called a C-reactive protein, on the blood, says Golding. Then we can intervene with simple supplements, such as curcumin.
This causes cancers, senescent cells and tumors, and accelerates aging. mTOR is the master anabolic regulator that organizes many other nutrient sensors, such as insulin, leptin and insulin-like growth factor (IGF-1), a hormone that supports growth development, healing, muscle-building and bone strengthening, depending on what the body needs.
Because mTOR is stimulated by insulin, growth factors, blood factors, phosphatidic acids and oxidative processes, when we eat, its best to avoid animal proteins and lots of processed sugars.
Dietary additions such as resveratrol and metformin have been shown to inhibit mTOR upstream. Metformin isnt available in stores, so ask your medical doctor for a prescription. Dont forget that resveratrol should betransandwhitein color.
Rapamycin supplementation has also shown promise with mTOR, but due to the serious side-effects, its not recommended.
This results in sarcopenia, loss of skeletal muscle mass and strength. It can also lead to catabolism of lean tissue and muscle disorders. This can accelerate premature aging and make you prone to other metabolic diseases. Because the body and all the cells consist of protein, which requires the presence of anabolic precursors and building blocks, you need mTOR and amino acids for existence and DNA repair.
Note: This article was co-authored with Longevity health writer Johane Du Toit and first appeared in Longevity magazine.
New research suggests that there may be a way to not only prevent premature aging, but possibly reverse it. In fact, for the first time ever, a human study has shown a reversal in the biology of aging, with hyperbaric oxygen therapy (HBOT).