Category Archives: Longevity

The message and optics of Joe Bidens address from September 1, 2022, were startling in our supposedly enlightened times. In the mid-1930s, however, both were conventional politics. This was a time in which the most menacing discovery of modern times came to be perfected in political rhetoric. That discovery was that the most successful path to regime stability is to unify political friends around loathing and hatred of some domestic enemy.

Who the enemy is can change. What matters most is that the enemy is seen as an existential threat to the friends of the nation. It must be called out, rooted out, disabled, and even eliminated. And the masses of people must go along with it, even participate in it. They must be driven to feel a kind of bloodlust a phrase that perfectly embodies the fullness of the insight.

The point deepens and extends Niccol Machiavellis prescription for political control. In his view, the priority should always be on crushing competitors to the throne. Only in this way can the Prince sleep well and the people live lives of peace.

Machiavelli lived in times of absolute power when the state was mortal, bound up with the life of a person. Democracy and the invention of the impersonal state changed the prescription for seizing and retaining power. It was no longer about keeping immediate competitors at bay. Now the effort had to involve the whole of the population.

It fell to Carl Schmitt (1888-1985), the German jurist and professor who deployed all his skills in service of Hitler, and yet still lived to a ripe old age, to map out the new path for the new age. His powerful essay The Concept of the Political (1932) remains the most poignant challenge to liberalism written in a century. Even today, it speaks clearly of the dark path to political success, and stands as a blueprint for any regime to deploy in service of survivability.

The essence he boiled down in a way that anyone can understand. The regime survives and thrives based on the friend/enemy distinction. The friends constitute the political community. The enemies are that which the community is organized against. Of whom the enemy consists does not matter. It can be identified by race, religion, ethnicity, age, body shape, geographynone of this is essential. All that matters is that 1) the people in power have made the decision, and that 2) it is believable to the majority of politically significant citizens which constitute the friends.

Reading the essay today, the political ethos of Nazism is easy to observe. Indeed, Schmitt wrote the formula, and not only for the enemization of Jews and others not loyal to the regime. His scheme applies more broadly to any regime that needs to shore up its standing and obtain total power. The killing fields are not a stretch either, given that he writes:

The state as the decisive political entity possesses an enormous power: the possibility of waging war and thereby publicly disposing of the lives of men. The jus belli contains such a disposition. It implies a double possibility: the right to demand from its own members the readiness to die and unhesitatingly to kill enemies.

To Schmitt, politics requires war either ongoing or as a believable threat. This war can be domestic or international. The main point is to reinforce the states right to dispose of life and encourage the population toward a willingness to do the deed or die trying. Only through this path is the stability and longevity of politics and the state assured.

Yes, he is the leading political theorist of totalitarian dictatorship. Schmitt regarded the concept of separation of powers, checks and balances, and constitutional restraints to be annoying impediments on the path toward the meaningful life lived through politics. Moveover, he views all these attempts to limit government to be foolhardy in practice and pointless in principle.

He argued that liberal democracy is unsustainable essentially because it is dull, especially one that elevates commerce as a first principle of human peace and belongingness. This, he argued, submerges primal instincts too deeply: heroism, battle, triumph, bravery, upheaval, and the need of everyone to make ones life count in the way that a Hegelian might understand that term. Yes, that involves bloodshed.

He regarded the dream of 19th-century-style liberalism to be nothing but a chimera. It longs for a society without politics, he said, but we need and require politics because we want belongingness and struggle, a mission that involves vanquishing the foe and rewarding ones own tribe that is loyal to the leader.

All the above he takes as a given. He reserves special disdain for Benjamin Constant (1767-1830) and his tremendous distinction between the liberty of the ancients and the moderns. For the ancients, he wrote, liberty meant having some say in the laws and regulation of public life. It was reserved for the few. But the modern began to imagine a new world of universal liberty and rights, most directly exercised through the ability to own property and engage in commercial exchange. To Constant, this was made possible by the rise and spread of wealth that took us far away from the state of nature in which we merely struggle to survive and instead live with the hope of a better and longer life.

Schmitt despised this view. He said that a population living a bourgeois life lacks meaning and will not long stand for such a superficial path of living. He proposes instead the concept of the political as a replacement, namely the struggle for control of the state and society as a whole. Essentially he wanted to revive the ancient form of liberty that Constant said was long past and good riddance.

Strangely, Schmitts memory does not live in disgrace. He is respected and even revered today in countries all over the world, and studied in every upper-level class in political philosophy. Every anti-liberal regime seems eventually to find its way to Schmitts writings.

Think back to the summer of 2021. The Biden administration was pushing its vaccine program with increasing vigilance against a hesitant population. A kind of fanaticism took over the White House with the conviction that there had to be 70-80 percent of the public jabbed for Biden to get the credit for ending the pandemic. The New York Times ran a special feature noting that 1) the highest infections were in the South, 2) the South by state was the least jabbed area of the country, 3) many of these people voted for Trump.

The next steps were obvious. By naming the enemy as the unvaccinated, the Biden administration could claim that they were prolonging the pandemic and also the political point was there too: Trump voters were wrecking the country. The propaganda line checked all the Schmittian boxes, even the one concerning death: recall the prediction of a winter of death for those who refuse the shot.

Of course it was only weeks later when the virus migrated to the Midwest and then the Northeast and the entire narrative fell apart. Thats when the Biden administration stopped decrying the pandemic of the unvaccinated.

Still, the habit had been engrained. From then on, the Schmitt template would be the go-to path to political security. This becomes all the more essential given Bidens low ratings and the widespread prediction that the Democrats could lose all control of Congress in November. Desperate times and desperate measures. Hence the September 1st speech that named the enemy and extolled the friends of the state.

What is Schmitts status today and do we have any proof that this is what drives the White House? We only have all the signs, symbols, and rhetoric. Schmitt is the muse. But there is more here too. The pandemic response itself which was Xi Jinpings curse on the world seems to borrow from Schmitts pages. Consider what Chang Che wrote about Schmitts influence on China in The Atlantic in December 2020:

China has in recent years witnessed a surge of interest in the work of the German legal theorist Carl Schmitt. Chinas fascination with Schmitt took off in the early 2000s when the philosopher Liu Xiaofeng translated the German thinkers major works into Chinese. Dubbed Schmitt fever, his ideas energized the political science, philosophy, and law departments of Chinas universities. Chen Duanhong, a law professor at Peking University, called Schmitt the most successful theorist to have brought political concepts into his discipline.

Chinese President Xi Jinping has markedly shifted the ideological center of gravity within the Communist Party. The limited tolerance China had toward dissent has all but dissipated, while ostensibly autonomous regions (geographically as well as culturally), including Xinjiang, Inner Mongolia, and Hong Kong, have seen their freedoms curtailed. All the while, a new group of scholars has been inascendance. Known as statists, these academics subscribe to an expansive view of state authority, one even broader than their establishment counterparts. Only with a heavy hand, they believe, can a nation secure the stability required to protect liberty and prosperity. As a 2012articleinUtopia, a Chinese online forum for statist ideas, once put it, Stability overrides all else.

In so many ways, the CCP influence has been felt in the US over the last two years, and all those have been chronicled at great length at Brownstone Institute, including of course the junket to Wuhan in February 2020, the close connections between the NIH/Fauci and the Wuhan lab, the manner in which the WHO celebrated Chinas great but fake success in suppressing the virus. To find out that Schmitt is strangely popular in the upper reaches of the CCP is perhaps startling but also perhaps not given everything we know.

The first time I wrote about Schmitt, it was within the context of the rise of the alt-right. Inspired by Trumps own deployment of the friend/enemy trope, a movement gained steam and prepared the way. The Biden administration escalated this trope, adding the Schmittian hint of bio-medical malice: accept the shot or be declared the enemy. Now it is only about raw power: dissent has been deemed as dangerously disloyal and too disruptive to tolerate.

As with the interwar period, it is striking how easily intellectuals and regimes can migrate from and to different ideological forms while retaining the philosophical orientation of that which they allegedly oppose. Friends and enemies become mirror images of each other, which is why Bidens speech calling for unity simultaneously called a large swath of the American electorate a threat to democracy, by which he means the state he rules.

Let us remember that Carl Schmitt despised America and everything it stood for, especially the idea of individual liberty and limits on government. Its one thing to study his writings in graduate school as a warning to what it means to turn against enlightenment values. Its another thing entirely to deploy his theories as a viable path to keeping power when it appears unstable, not only in Beijing but also Washington, DC. That should truly terrify all of us.

Jeffrey A. Tucker, Founder and President of the Brownstone Institute, is an economist and author. He has written 10 books, including Liberty or Lockdown, and thousands of articles in the scholarly and popular press. He writes a daily column on economics at The Epoch Times, and speaks widely on topics of economics, technology, social philosophy, and culture.

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The Return of Carl Schmitt and His Scheme for Regime Longevity - Brownstone Institute

New Delhi: Widely considered one of the most significant figures of the second half of the 20th century, Mikhail Gorbachev, the last president of the Soviet Union passed. Gorbachev, credited with ending the Cold Wat without any bloodshed lived till the age of an astounding 91 years, even though was suffering from long and a serious illness that has always been shrouded in mysteries. Earlier this year Gorbachev, whose biggest contribution was to provide Russians with freedom of speech and multi-party democracy, had been hospitalized for an unknown kidney ailment, which media reports said was dialysis treatment but was refuted by the Tass. The cause of his death has not been announced yet.

A few years back, Australian media had also said he was suffering from severe diabetes, a claim not verified.

Secrets of Gorbachevs longevity

According to the Tass, the Nobel Prize winner will be buried in Moscow's Novodevichy cemetery, next to his wife Raisa.

Unabashed love for family and celebration of bondsGorbachev was married to Raisa for 46 years before she died of leukemia in 1999. In the volumes of his memoirs, which he had dedicated to her, Gorbachev had mentioned being heartbroken by her death. He loved traveling and used to take short breaks with his family to rejuvenate and recuperate from the stressful work times.Gorbachev's memoirs also feature pictures from the various family holidays taken in and outside Russia.

Love of Music: A great stress buster

In the dark night, I know that you, my love, are awake, sitting by the crib you're secretly wiping away a tear; How I love your deep gentle eyes, how I want to press my lips to yours," he sang for an interview to the BBC way back in 2013.

Unfailing sense of humor

Gorbachev was also known for his humorous takes on serious politics. According to various journalists who interviewed him, especially after he left office, Gorbachev used to take a dig at himself quite often. "Look, now I need three legs to get around!" He told BBCs Steve Rosenberg in Moscow after he started using a stick to walk around. "What happened to the USSR was my drama. And a drama for everyone who lived in the Soviet Union," he chuckled as he spoke about the fall of the USSR.

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Know 3 longevity secrets of the last USSR President Mikhail Gorbachev who died at the ripe age of 91 - Times Now

Longevity is an important aspect and factor when it comes to evaluating all-time athletes in any sport. The ability to maintain one's greatness is important, as it shows that someone can be a winning player over a period of time rather than having a short peak and a worse overall career.

There are a lot of legends playing professional sports currently that have elite longevity. Tom Brady is still a good quarterback in the NFL, Serena Williams has recently moved on to the third round of the 2022 US Open after upsetting her opponent, while LeBron James is still a superstar in the NBA. We are witnessing greatness all around.

Recently, Philadelphia 76ers guard Tyrese Maxey offered some praise for LeBron James, Serena Williams, and Tom Brady and their longevity. He jokingly asked about what is "in the water" that those three athletes are drinking, and it's clear that Maxey is amazed atwhat those legendary stars have been able to accomplish.

What is in the water Bron, Serena, and TB12 drinking!? At this point Im just curious!

There is no doubt that those athletes have had long and productive careers and will retire as legends of their respective sports. Most NBA fans know that LeBron James' longevity in the sport is absolutely unprecedented. Once, former player Eddie Johnson pointed out that players such as Magic Johnson and Larry Bird were "no longer relevant" by the time they were LeBron James' age, and noted that this "lets you know how great" James actually is.

Its amazing how LeBron at almost 37 is still being ripped for struggling, when he has an AD in his prime and not living up to expectations. Magic, Bird, Duncan, Hakeem, and Jordan were no longer relevant at 37. That lets you know how great LBJ is. Keep it moving."

Hopefully, we see LeBron James have another good year with the Los Angeles Lakers next year. While the team missed out on the playoffs this past season, they have revamped their roster, and perhaps that will lead to a different outcome for the next year.

As for Tyrese Maxey, he will likely be focused on trying to win a championship with the Philadelphia 76ers. Many expect him to become the third star of the franchise behind James Harden and Joel Embiid, and he definitely has the talent to do so.

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Tyrese Maxey Lauds LeBron James, Serena Williams, And Tom Brady For Their Longevity: "What Is In The Water Bron, Serena, And TB12...

The USs life expectancy continued its decline from 2020 to 2021, dropping sharply to 76.1 years.

With the latest decline, US life expectancy is now at its lowest since 1996, according to new data (pdf) from the Centers for Disease Control and Preventions (CDCs) National Center for Health Statistics. It also means that the gap in longevity at birth between people in the US and China has now widened to a full year.

The biggest driver in the drop in US life expectancy is covid, accounting for 50% of the decline, according to the CDC. Government figures show that as of Aug. 31, over 1.04 million deaths in the US have been attributed to covid.

Unintentional injurieswhich include opioid overdoses and motor vehicle crasheswere the second-largest contributor to the drop in life expectancy, making up 15.9% of the decline.

Chinese data on life expectancy for 2021 is not yet available. Remarkably, however, Chinese life expectancy actually increased by 0.2 years in 2020 from the year prior. By contrast, US life expectancy fell 1.8 years in 2020 over the same period.

A key reason for the disparity is Chinas stringent covid controls, beginning in the early days of the pandemic, with the Wuhan lockdown that began in January 2020, and continuing with todays aggressive zero-covid policies.

Beijing has repeatedly said that it cannot diverge from its zero-covid approach without further safeguards such as higher vaccination rates, as doing so would risk 1.5 million deaths nationwide. As of March, vast swathes of the elderly Chinese population were still unvaccinated or not fully vaccinated, according to official figures. An attempt to implement a vaccine mandate in Beijing in July was abruptly rolled back.

Still, while China now has several homegrown covid interventions, including an antibody therapy combination and a promising antiviral pill candidate winding its way through the regulatory approval process, Beijing shows no signs of easing off its zero-covid strategy.

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China's life expectancy is now higher than that of the US - Quartz

If you are shopping for an all-wheel-drive Subaru, which is the most reliable, dependable model that will last the longest? New car shoppers and used car buyers are looking for the best value and can know which vehicles will be on the road longer than other models. A new report from IHS Markit, now part of S&P Global data, reveals which Subaru models last the longest.

One Subaru SUV has the most model years that are still on the road today. The data reported by S&P Globals recent research data reveals that 96 percent of all Subaru models sold over the last ten years are still on the road. The data is based on IHS Markit research on vehicles in operation as of June 30, 2022, for model years 2013 to 2022 versus the total new registrations of those vehicles.

How reliable are Subaru vehicles over the last ten years, and which model has lasted the longest?

The Subaru Outback midsize SUV takes the longest-lasting crown but not by much. The data says that 97 percent of Outback vehicles sold over the last ten years are still on the road today.

Subaru Forester is the second longest-lasting Subaru model

The Subaru Forester compact SUV is right behind the Outback, with 96 percent of the compact SUVs sold over the last ten years still on the road today.

The Subaru Impreza compact sedan and hatchback models and the Subaru Legacy sedan are the next longest-lasting models. S&P Global says 95 percent of Impreza and Legacy models from 2013 to 2022 are still on the road today.

What is the longevity of the Subaru WRX, WRX STI, and Subaru BRZ?

The performance of Subaru WRX and STI is still above 90 percent. The report says 93 percent of the sport-tuned WRX and performance-tuned WRX STI vehicles sold over the last ten years are still on the road today.

What is the lowest performing model?

Do BRZ owners drive the sports car harder than other models? The report says 86 percent of BRZ sport coupes are still on the road. Surprisingly, the BRZ is Subarus lowest performing model in longevity.

Where does the Subaru Crosstrek rank in longevity?

The S&P Global report does not rank the Subaru Crosstrek subcompact SUV. We know its rated one of the most reliable Subaru models by Consumer Reports. The Subaru Ascent 3-Row family hauler was new in 2019, and there is not enough data on the midsize SUV.

Overall, S&P Global and IHS Markit data reveals that 96 percent of 2013 to 2022 model year Subaru vehicles sold over the last ten years are still on the road today. The Subaru Outback ranks best.

You Might Also Like: 8 Used 2-Row SUVs With The Best Fuel Economy - Subaru Outback Ranks 2nd

Denis Flierl has invested over 30 years in the automotive industry in a consulting role working with every major car brand. He is an accredited member of the Rocky Mountain Automotive Press. Check out Subaru Report where he covers all of the Japanese automaker's models. More stories can be found on the Torque NewsSubaru page. Follow Denis on Facebook, Twitter, and Instagram.

Subaru Report - Weve got you covered! Check back tomorrow for more unique, informative SUBARU news, reviews, and previews you can trust.

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Which Subaru Vehicle Is The Most Reliable? One Model Lasts The Longest - Torque News

EARD2022 is over, but the research and events continue. Heres a summary of everything thats happened in August.

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Announcing the Longevity Prize: The Longevity Prize is a series of prizes designed to honor the researchers who are helping to build a future in which age-related diseases are a thing of the past. This new initiative aims to accelerate progress in the rejuvenation biotechnology field and encourage innovation.

Stephanie Dainow to Present at the 9th ARDD Conference: On August 22, 2022, Lifespan.io Executive Director Stephanie Dainow participated in the Decentralized Science and Blockchain session as a part of the Emerging Tech Workshop at the worlds largest annual Aging Research and Drug Discovery conference (9th ARDD).

Longevity Camp: The Longevity Summer Camp is a four-day retreat featuring people from many longevity-related walks of life. Recently, somewhere between the former gold mining town of Nevada City and the infamous Donner Pass, a unique gathering took place.

Cells Return from Death: Cells, dead for an hour under warm conditions, have been revived. Questions about when life begins have been hot topics for awhile, but there is also debate about when life ends.

Rapamycin and Metformin: Rapamycin and metformin, two well-studied drugs in aging research, can be combined for synergistic effects in mice. Rapamycin and metformin are viewed by many as the two most promising anti-aging drugs, but now scientists have found that these drugs can work hand in hand.

Steve Horvath on the Present and Future of Epigenetic Clocks: Dr. Steve Horvath is the inventor of the epigenetic clock and, currently, principal investigator at Altos Labs. We talked about the recent developments in this immensely important field, including pan-mammalian clocks, two-species clocks, and single-cell clocks, along with the challenges the field faces.

Prof. Albert-Lszl Barabsi on Network Medicine: Albert-Lszl Barabsi is the Robert Gray Dodge Professor of Network Science at Northeastern University, and he also holds an appointment in the Department of Medicine at Harvard Medical School. We talked about a revolutionary network medicine approach that can greatly enhance our ability to understand biological processes and seek cures for disease.

Martin ODea Talks About the Longevity Summit: We recently had the opportunity to speak to Martin ODea about a new longevity-focused event happening in Irelands capital city on September 18th-20th. Martin holds an MBS and is a business lecturer at Dublin Business School in Dublin, Ireland. He is also the author of Beyond the Subjectivity Trap.

Dr. Aubrey de Grey Will Speak at the Longevity Summit Dublin: We recently caught up with Dr. Aubrey de Grey and talked to him about the upcoming Dublin Longevity Summit and how things are looking on the advocacy landscape.

Ryan OShea of Future Grind hosts this months podcast, showcasing the events and research discussed here.

Old Plasma Dilution Reduces Human Biological Age: The Journal Club has returned to our Facebook page with your host, Dr. Oliver Medvedik. This month, we have investigated a paper, Old plasma dilution reduces human biological age: a clinical study, in which Irina Conboy and her team investigated the effects of therapeutic plasma exchange on aging in people.

Vitamin D Fails to Improve Bone Health in Mega-Study: A high-quality, randomized, controlled trial found no effect of vitamin D supplementation or blood levels on the incidence of fractures in an aging population.

Hesperetin Upregulates Metabolism and Longevity in Mice: Researchers publishing in Journal of Biomedical Science have concluded that hesperetin, a compound found in various herbs, improves longevity in mice by promoting the expression of the pro-longevity gene Cisd2.

Caloric Restriction Improves Immune System Function: A new study published in Mechanisms of Aging and Development has shown that caloric restriction effectively restores T cell abundance in aged mice. Caloric restriction has become a well-known anti-aging intervention, as it can reverse several hallmarks of aging and extend lifespan in different animal models.

Ghrelin Is Associated with Worse Muscle Aging in Mice: A team of researchers publishing through Multidisciplinary Digital Publishing Institute has described an association between ghrelin and skeletal muscle aging in mice. Ghrelin is a peptide containing 28 amino acids. Its main function is to stimulate the appetite through receptors in the hypothalamus.

Sauna Combined with Exercise Improves Cardiovascular Health: In a randomized, controlled trial, scientists have shown that sauna and exercise, when taken together, might have a synergistic, beneficial effect on cardiovascular health and cholesterol levels. Sauna bathing has been credited with many health benefits, predominantly for the cardiovascular system.

Developing Nanobodies to Fight Parkinsons Disease: A team of researchers publishing in Nature Communications has described nanobodies that can destroy the -synuclein aggregates that characterize Lewy bodies, which are associated with dementia and Parkinsons disease. Traditional antibody therapies, while promising in some studies, are too large to enter cells in order to affect the aggregates there.

Scientists Move the Boundaries of Post-Mortem Recovery: Researchers have been able to achieve substantial recovery of cellular and organismal activity in pigs that had been dead for a full hour. Advances in resuscitation have already moved the boundaries of life and death, making it possible to revive a person several minutes after the heart stops beating.

An In-Depth Review of Skin Aging Genes: In a new systematic review published in Scientific Reports, multiple genes driving skin aging were identified. The authors start by explaining the intrinsic (genetic and chronological) and extrinsic (environmental) factors that drive skin aging.

Hypertension Is Associated with Brain Drainage Changes: Researchers publishing in Aging have found that enlarged perivascular spaces in the brain are correlated with vascular disorders. These spaces, which are part of the brains glymphatic system, allow for the drainage of potentially dangerous metabolites such as beta amyloid.

Rapamycin-Loaded Microneedles Reverse Hair Loss in Mice: Scientists have successfully regrown hair in a mouse model of hair loss using custom-made plastic microneedles loaded with rapamycin and epigallocatechin gallate (EGCG), an active ingredient in green tea.

Identifying Mitonuclear Genes for Longevity: Publishing in GeroScience, a team of researchers that included Nir Barzilai and Matt Kaeberlein examined genes that may affect both mitochondria and lifespan.

Dietary Restrictions Do Not Help Cognitive Function in Mice: A new study published in Neurobiology of Aging has shown that neither caloric restriction nor intermittent fasting improve late-life cognition in genetically diverse mice, but the effect depends on genetic composition.

Combining Senolytic Pathways Has Synergistic Effects: A team of researchers have explained in Aging how multiple compounds that target the BCL-2 protein family are considerably more effective against senescent cells than each compound by itself.

New Synthetic Molecule Alleviates Alzheimers in Mice: Scientists have synthesized a molecule that alleviates Alzheimers in a mouse model by targeting inflammation. Two of the most prominent and probably interconnected symptoms of Alzheimers disease are the accumulation of amyloid beta (A) and chronic neuroinflammation.

The Relationship Between Stroke and Inflammation: Publishing in Aging, a team of Chinese researchers has provided evidence showing a relationship between systemic inflammation and prognosis after a stroke. As the researchers point out, strokes are the leading cause of death in China.

Almost Half of Cancer Deaths Worldwide are Preventable: Researchers have shown that 44.4% of cancer deaths worldwide can be attributed to preventable risk factors, including behavioral and environmental ones. It is well known that many cancer cases occur due to behavioral and environmental and factors such as smoking and pollution, which makes them theoretically preventable.

Rapamycin and Metformin Show Synergy in Mice: Scientists have found that rapamycin and metformin work hand in hand in diabetes-prone mice, boosting each others effectiveness and blocking side effects. Both have been in use for various indications for decades and have decent safety profiles.

Plasma Dilution Appears to Rejuvenate Humans: Published in GeroScience, a groundbreaking study from the renowned Conboy lab has confirmed that plasma dilution leads to systemic rejuvenation against multiple proteomic aspects of aging in human beings. This paper takes the view that much of aging is driven by systemic molecular excess of signaling molecules, antibodies, and toxins.

Mitochondrial Drug Alleviates Atherosclerosis in Mice: Scientists have drastically improved various symptoms of atherosclerosis in mice by precisely targeting mitochondria with a plant-derived antioxidant. Atherosclerosis, the accumulation of plaques on arterial walls, is one of the deadliest age-related diseases.

Intravenous Stem Cells Alleviate Guinea Pig Osteoarthritis: Scientists have shown that intravenous delivery of mesenchymal stem cells, which has some advantages over the more conventional intra-articular injection, alleviates age-related osteoarthritis and decreases inflammation in guinea pigs. Osteoarthritis, a degenerative joint disease, is one of the most common causes of disability in old age.

Glycans as Biomarkers of Aging: In a new review published in Clinica Chimica Acta, researchers from the University of Zagreb discuss immunoglobulin G glycans, the changes that their composition undergoes with aging, and their potential as biomarkers of aging. One of the reviews co-authors is Prof. Gordan Lauc, who gave a presentation on them at EARD2022.

A wearable electrochemical biosensor for the monitoring of metabolites and nutrients: The monitoring of metabolites for the early identification of abnormal health conditions could facilitate applications in precision nutrition.

Epigenome-wide association study analysis of calorie restriction in humans, CALERIE TM Trial analysis: DNA methylation changes may contribute to caloric restrictions effects on aging.

Association of Leisure Time Physical Activity Types and Risks of All-Cause, Cardiovascular, and Cancer Mortality Among Older Adults: There were significant associations between participating in 7.5 to less than 15 MET hours per week of any activity and mortality risk.

Ginkgo biloba extract EGb 761 plus acetylcholinesterase inhibitors improved cognitive function in patients with mild cognitive impairment: These findings suggest that combined therapy with EGb 761 plus AChEI may provide added cognitive and functional benefits in patients with MCI.

Suppression of trimethylamine N-oxide with DMB mitigates vascular dysfunction, exercise intolerance, and frailty associated with a Western-style diet in mice: These therapies may be promising for mitigating the adverse effects of a Western diet on physiological function and thereby reducing the risk of chronic diseases.

Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice: Canagliflozin can be considered a drug that acts to slow aging and should be evaluated for potential protective effects against many other late-life conditions.

Fecal microbiota transplantation can improve cognition in patients with cognitive decline and Clostridioides difficile infection: This study revealed important interactions between the gut microbiome and cognitive function. Moreover, it suggested that FMT may effectively delay cognitive decline in patients with dementia.

Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy: As mitochondrial fission occurs less frequently in the satellite cells in older humans, these findings have implications for regeneration therapies in sarcopenia.

Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation: These findings demonstrate that the plasticity of the aging brain can be selectively and sustainably exploited using repetitive and highly focalized neuromodulation

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Aging Hallmarks: By combining the benefits of glycine, NAC and GSH, GlyNAC is an effective nutritional supplement that improves and reverses multiple age-associated abnormalities to promote health in aging humans.

VitaDAO Funds ApoptoSENS Project for $253,000: Preventing the dysfunction of natural killer cells may be a promising area to explore in the fight against cellular senescence. Researchers are hoping to define the correlation between the increase in senescent cells and the onset or worsening of disease in humans.

VitaDAO Backs Research into Chronic Oral Disease: Periodontal disease affects more than 47% of adults aged 30 and over. For people over 65 years of age, that number rises to over 70%, making periodontitis one of the most commonly observed age-related illnesses. Jonathan Ans lab seeks to research inflammation-targeting compounds that can help treat periodontal disease.

Researchers Propose Five New Hallmarks of Aging: Publishing in Aging five months after their panel discussion in Copenhagen, many well-known researchers have explained their reasons for wishing to add new hallmarks of aging to the existing paradigm.

SENS Research Foundation Announces Ending Aging Forum 2022: SENS Research Foundation has announced this years Ending Aging Forum, which will be held through a virtual conference platform with an immersive environment.

Longevity Investors Conference: Organized and sponsored by Maximon, the Longevity Investors Conference is focused on the investment aspects of longevity. The LIC welcomes everyone with an interest in the financial aspects of the longevity sector, including venture capitalists, asset managers, and managers of private equity funds and private banks.

Longevity Summit Dublin: This conference will feature two days of inspiring research developments along with top longevity entrepreneurs, biotech companies, longevity investors, and researchers from around the world.

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Rejuvenation Roundup August 2022 - Lifespan.io News