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Category Archives: Longevity
It is inspiring to see age is no barrier for the highest office in the land. Joe Biden, 78, is the oldest person in U.S. history to become president. Bidens predecessor of a century earlier, Warren G. Harding, was 55 years old when he took office in 1921, and he died halfway through his term at 57, as if on cue, given the prevailing life expectancy at the time of 57.5 years.
These age differences are symptomatic of continuously increasing life expectancy. As recently as 1800, life expectancy at birth in America was 35 years, grew slowly to 39.4 years in 1880, and more rapidly thereafter, to 78.9 in 2019.
Nobel laureate Angus Deaton wrote in his book The Great Escape: Health, Wealth, and the Origins of Inequality: The greatest escape in human history is the escape from poverty and death. These dramatic increases in longevity arose from medical and public health improvements: controlling infectious diseases through antibiotics, antivirals and vaccines; improved diet, water and sanitation; and greater access to education and pharmaceuticals.
There is little reason for these advances to stop; researchers have recently identified a longevity gene and restored lost sight in mice, offering clues to reversing aging in humans. Female life expectancy is already approaching 90 in East Asia, and research published in Millbank Quarterly projected longevity to rise higher than 93 years by 2050 in the U.S.
While there are still gaps between life expectancies Black people still live, on average, 3.6 fewer years than white people, according to research published in Nature for the population as a whole, mortality rates have declined over the past century and this gap has narrowed. COVID-19 will almost certainly represent a setback to life expectancy in America, but we expect that will be temporary as long as the speed of pharmaceutical and biomedical innovation can keep pace with the evolution of vector-borne diseases.
While the life sciences can describe and chart this remarkable trajectory in life expectancy, we focus on the implications of having all these extra years. Just as a landowner whose holdings are bounded by a river is given the gift of expanded acreage when the river shifts over time, humans have been granted the gift of time. And as the farmer must decide what to do with the additional land, tend to it or leave it fallow, humans need to plan for the additional time.
For the average American in 1800, as the English philosopher Thomas Hobbes presaged, life was poor, nasty, brutish and short. The workforce was predominantly agricultural, and 95% of the population was rural. Generations three, if a family was fortunate tended to live in the same community, many in the same home. Children needed to be born, raised and brought into adulthood while their parents were still alive and able to provide for them. For most, life unfolded at a rapid clip, and there was little time for leisure or exploration.
As the agricultural transformation ushered in by the industrial revolution unfolded, American families moved from farms to cities to take up the plentiful industrial jobs. In 1890, 35% of the population was urban and by 1920 a majority lived in cities. Life expectancy correspondingly increased over this period by nearly 50%.
Working lives have expanded with life expectancy. It was once uncommon for someone to work beyond his or her sixth decade, but now many even work into their eighth decade. According to the U.S. Bureau of Labor Statistics, men and women age 75 and older are projected to have the fastest growth rate in the U.S. labor force.
Increased longevity comes with its challenges such as physical disabilities and cognitive decline. In the U.S., 3.4 million workers provide paid home care, according to the Bureau of Labor Statistics, and the National Alliance for Caregiving reported nearly 53 million Americans provide unpaid care to adults with a disability or illness. People providing dementia care, paid or unpaid, for our oldest outnumber by over four times the 3.2 million teachers in public K-12 schools providing education for our youngest.
However, longer lives also represent opportunity. There is time for family and community; for learning, adventure and exploration; and for contributions to our families, communities and workplaces.
What will Americans do with all the extra time, as 100 might be a ripe old age instead of 60 a century ago? Several policy areas clamor for attention. To ensure that health and well-being continue into these extended lives, new policies may be needed to ensure these extra years become mutually beneficial to all generations. Outdated social systems, norms and institutions that made sense when life expectancy was half of what we expect our children to experience could be reimagined.
Given life expectancy is likely to increase further, it makes sense to examine the economic and social systems to see if they will be resilient to future demographic changes. Closing the gaps in longevity by race and ethnicity could also be a priority. We may have to rethink life possibilities when four generations routinely overlap and interact, and reconsider lifelong learning and retirement when lives are this long.
The swearing-in of our oldest president is an occasion to widen our understanding of acceptable ages for all occupations and activities. It can lead us to envision a society and an economy that values increased life spans as tremendous opportunities to create, innovate and thrive.
The jazz legend Louis Armstrong, who died a month before his 70th birthday in 1971, again in sync with the prevailing life expectancy of just under 70, sang, We have all the time in the world. It is up to us to craft an answer to the question: What will we do with it?
Andrew Hoehn is senior vice president of research and analysis at the nonprofit, nonpartisan Rand Corp.
Bonnie Hagemann is chief executive of EDA Inc.
Krishna B. Kumar is director of international research at Rand Corp. and director of the Initiative for Global Human Progress at the Pardee Rand Graduate School.
They wrote this column for The Dallas Morning News.
Got an opinion about this issue? Send a letter to the editor, and you just might get published.
Longevity and Anti-senescence Therapy Market Report By Application, Type, Top Companies, Growth, Regional Outlook, and Forecast to 2027 Murphy’s…
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Light-activated genes illuminate the role of gut microbes in longevity – Baylor College of Medicine News
Getting old is a complex matter. Research has shown that gut microbes are one of the factors that can influence several aspects of human life, including aging. Elucidating how a specific microbial species contributes to longevity is quite challenging given the complexity and heterogeneity of the human gut environment.
To explore the influence of bacterial products on the aging process, researchers at Baylor College of Medicine and Rice University developed a method that uses light to directly control specific gene expression and metabolite production from bacteria residing in the gut of the laboratory worm Caenorhabditis elegans.
We used optogenetics, a method that combines light and genetically engineered light-sensitive proteins to regulate molecular events in a targeted manner in living cells or organisms, said co-corresponding author Dr. Meng Wang, Robert C. Fyfe Endowed Chair on Aging and professor of molecular and human genetics and the Huffington Center on Aging at Baylor.
In the current work, the team engineered E. coli bacteria to produce the pro-longevity compound colanic acid in response to green light and switch off its production in red light. They discovered that shining the green light on the transparent worms carrying the modified E. coli induced the bacteria to produce colanic acid, which protected the worms gut cells against stress-induced mitochondrial fragmentation. Mitochondria have been increasingly recognized as important players in the aging process.
When exposed to green light, worms carrying this E. coli strain also lived longer. The stronger the light, the longer the lifespan, said Wang, an investigator at Howard Hughes Medical Institute and member of Baylors Dan L Duncan Comprehensive Cancer Center. Optogenetics offers a direct way to manipulate gut bacterial metabolism in a temporally, quantitatively and spatially controlled manner and enhance host fitness.
For instance, this work suggests that we could engineer gut bacteria to secrete more colanic acid to combat age-related health issues, said co-corresponding author Dr. Jeffrey Tabor, associate professor of bioengineering and biosciences at Rice University. Researchers also can use this optogenetic method to unravel other mechanisms by which microbial metabolism drives host physiological changes and influences health and disease.
Read the complete report in the journal eLife.
Other contributors to this work include first author Lucas A. Hartsough, Mooncheol Park, Matthew V. Kotlajich, John Tyler Lazar, Bing Han, Chih-Chun J. Lin, Elena Musteata and Lauren Gambill. The authors are affiliated with one of more of the following institutions: Baylor College of Medicine, Rice University and Howard Hughes Medical Institute.
Funding for this project was provided by Human Health Services and National Institutes of Health grants (1R21NS099870-01, DP1DK113644 and R01AT009050), National Aeronautics and Space Administration (grant NSTRF NNX11AN39H), the John S. Dunn Foundation and the Welch Foundation.
By Ana Mara Rodrguez, Ph.D.
It makes sense that Blander sees so many individuals low in iron; iron deficiency affects about 20 to 25% of the world's population, after all, primarily women. Thats because common causes of iron deficiency include heavy bleeding during menstruation and pregnancy (as the growing baby needs greater amounts of blood)both of which predominantly affect premenopausal women. Of course, these are not the only causes of iron deficiency (others include inadequate nutrition or certain medical conditions), but it does make sense why the stats are higher in women.
As for the exercising bit, an intense workout increases your red blood cell production (which is where your iron lives), but you can lose more of it through sweat as well as a concept called exercise-induced hemolysis, which is when those blood cells become ruptured during high impact (like, say, when the soles of your feet hit the pavement while you run). In other words, high-intensity exercise causes a high turnover rate for your red blood cellsand if you don't have enough iron to meet the demand, a deficiency isn't out of the question.
"That's a big problem," says Blander, not only for your workout itself (specifically, it can impair endurance and cause shortness of breath) "but also if you are trying to improve your performance at work." When you don't have enough iron, you can feel tired, get headaches, or feel restlessall of which are not so conducive to a productive work environment.
Longevity and Anti-senescence Therapy Market Detail Analysis focusing on Application, Types and Regional Outlook – AlgosOnline
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For most small businesses, it was a rough year. Many owners learned that they now need to build a business with a longevity plan in place and not just think about how to generate revenue this month.
On the Small Business Radio Show this week, Seth Kaplowitz, an attorney who brings his practical and legal experience directly to entrepreneurs, discusses a plan that focuses on growth and exit opportunities.
Seth believes that small business owners dont focus on the long term because they are looking at generating short term revenue. He says that while this is important, they also need to be aware how what I do today is going to affect the business 5 to 10 years from now. It is critical to create business assets that are monetizable and not only what generates business now. In any longevity plan, Seth suggests looking now at what your goals are and over what period of time you want to achieve it.
One of the roadblocks for a longevity plan this year for small businesses has been to navigate all the existing and new local, state and federal regulations. With COVID, Seth notes that the volume of regulations has increased and they have been drafted quickly to deal with the urgent situation. He suggests staying connected to your state and local government and understand what their requirements are since not following them could later be very costly.
Listen to the entire episode of the Small Business Radio Show.