Category Archives: Longevity

Warren Lee, 106, of LaFayette, died Sunday, September 25, 2022, at his home, one month shy of his 107th birthday.

He was born at the family home on Brewer Road in Amber in 1915, according to his obituary. He grew up on a successful farm that produced a specialized cigar tobacco, along with the other crops. In subsequent years, the Lee family moved to different locations in Marcellus.

He remembered World War I soldiers marching through the streets of Marcellus and the 1918 flu, according to his obituary. He attended schools in Marcellus, Onondaga Valley Academy and Vocational High School.

He worked for Hitchings Apple Orchards, then Beak and Skiff Apple Orchards, where he learned the horticultural techniques of budding and grafting. He was promoted to oversee the cold storage equipment and finally took charge of the orchard equipment maintenance and repair operation.

He eventually began an independent automotive repair business, according to his obituary. During the early years of his business, he taught welding. He also earned an adult education teaching certificate in 1954 and taught welding night school classes in his garage for Onondaga Central School.

During the time of Cold War international tensions, he trained and became a Civil Defense Police Officer.

Asked about the possible reasons for his long life, Warren offered these tips:

Hard work, a good wife, staying slim and active, country living, deep well water, fresh vegetables and a positive outlook with good humor.

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Todays obituaries: Living to nearly 107, Warren Lee shared his tips for long life in his obituary - syracuse.com

Ryan Corr Photo: Brendon Thorne (Getty Images)

Spoiler warning: This article contains details about key plot points and developments in House Of The Dragon episode six.

Even fabricated history repeats itself. HBOs House Of The Dragon, which travels back roughly 200 years before the events of Game Of Thrones, has proven so far that unexpected, brutal deaths have always been Westeros bread and butter. Both series penchant for killing off anyone and everyone has led to jokes about job security for the series actors. But for the actors who play murdered characters, like Ryan Corr, its nice to have a well-populated graveyard from which to take inspiration.

Corr plays Ser Harwin Breakbones Strong on House Of The Dragon, who (alongside his father) faced death by all-too-literal fire and brimstone in the series most recent episode. Speaking with The A.V. Clubs Cindy White in a new interview, Corr reveals that House Of The Dragon creator Ryan Condal actually directly drew the connection between Strong and Pedro Pascals unforgettably-offed Red Viper of Dorne (also known as Oberyn Martell.)

Corr says Condal emphasized how [the Viper] was there for a limited amount of time but his presence lingered, long after his death and throughout. Obviously theyre very different characters, but [Condal and co-creator Miguel Sapochnik] saw their impact as being similar, Corr shares.

For Corrs onscreen father Gavin Spokes (who plays the also-deceased Ser Lyonel Strong), a different character of the beheaded persuasion comes to mind: the former King of the North.

The good die young, Spokes muses. I mean, Lyonel was not very young, but yes, exactly. We keep up that tradition Ned Stark so beautifully launched for us all.

Youd be very wary of falling in love with characters on [Game Of Thrones] because they were all killed, Corr agrees. But that was sort of one of the ideas, too. We spoke to Miguel [Sapochnik] and he said, We want to rip their heart out.

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House Of The Dragon's Ryan Corr talks the unexpected longevity of Pedro Pascal's Red Viper - The A.V. Club

New research suggests that moderate caloric restriction in humans has benefits beyond weight loss. In a two-year study, researchers saw improved immune function and T cell production, and a reduction in inflammation in participants who reduced their calories by about 14 percent.

Caloric restriction (CR) has been an important topic in aging and longevity research for many years. Weve learned from studies on many types of animalsfrom flies to mice to nonhuman primatesthat moderate CR without malnutrition prolongs lifespan, slows biological aging, and delays the development of chronic diseases.

More recent research has tried to understand the biology behind the beneficial, longevity-promoting effects of CR, and how it could be used to improve human health. The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) trial was the first CR trial conducted in healthy humans. Participants in the CR group were instructed to reduce calorie intake moderately (a goal of 20 percent) for two years.

Previous results from the CALERIE trial suggested moderate CR reduced fat mass, improved insulin sensitivity, reduced inflammatory markers, and improved cardiovascular risk biomarkers.

A new study from the CALERIE trial investigated immune function and gene expression in fat tissue in participants who restricted calories by an average of 14 percent for 2 years.

Some research in animals had suggested that CR could impair immunity. However, these studies usually reduced calories more dramatically, by about 40 percent. These animals lived longer, on average, than control animals but were more susceptible to infection. This suggests that a 40 percent calorie reduction led to insufficient resources for the immune system. Moderate CR of 14 percent, however, in the CALERIE trial, showed signs of improved immune function in the newly published study.

The researchers chose to analyze the thymus, where T cells (a subset of immune cells) mature, in CALERIE participants, because aging of the thymus begins earlier than other organs. Starting in middle age, the thymus begins to shrink, accumulate fat, and release fewer T cells, reducing the capacity for immune surveillance.

Using MRI and indicators of T cell abundance in the blood, the researchers determined that the thymus glands in the CR participants were larger and less fatty, and were releasing more T cells after two years than they were at the beginning of the study, whereas the control group showed no change.

Since excess fat tissue drives inflammation and inflammation drives aging, the researchers also investigated gene expression in adipose (fat) tissue at baseline, one year, and two years of caloric restriction. They found increases in the expression of 233 genes and decreases in 131. Several of the largest gene expression changes were indicative of a lower level of inflammation.

They focused on one particular gene: the platelet-activating factor acetylhydrolase (PLA2G7), whose expression was decreased in response to CR. Little is known about PLA2G7 so far. However, higher circulating levels of PLA2G7 have been linked to inflammation-related diseases such as cardiovascular disease, autoimmune disease, and Type 2 diabetes.

They investigated PLA2G7 further by deleting the gene in mice, and found lower circulating proinflammatory cytokines, reduced inflammation in fat tissue, limited weight gain, and maintenance of the volume of the thymus compared to control animals. These results are consistent with improved immune health and lower inflammation, and were similar to the results in humans under moderate CR, suggesting PLA2G7 is an important gene underlying the benefits of CR.

Overall, the findings from this study suggest that moderate caloric restriction alters gene expression to promote immune function and reduce inflammation, strengthening the evidence that moderate caloric restriction in the context of micronutrient excellence extends life span.

I developed the nutritarian diet,a plant-based, nutrient-dense diet, as a powerful way to reverse chronic disease, strengthen immune defenses, and slow the aging process. Its unique in that it pays attention to comprehensive micronutrient adequacy using a wide variety of nutrient-rich foods along with a judicious use of supplements (such as DHA and EPA omega-3 fatty acids, vitamins B12 and K2, zinc, and iodine) to prevent any insufficiencies from reducing or eliminating animal products. This nutritarian approach lowers the instinctual drive for calories, allowing people to be satisfied with fewercalories and enjoy eating more.

Sources:Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential

Caloric Restriction in Humans Reveals Immunometabolic Regulators of Health Span

A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity

Calorie Restriction Enhances T-Cell-Mediated Immune Response in Adult Overweight Men and Women

Body-Composition Changes in the Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE)-2 Study: A 2-y Randomized Controlled Trial of Calorie Restriction in Nonobese Humans

2 Years of Calorie Restriction and Cardiometabolic Risk (CALERIE): Exploratory Outcomes of a Multicentre, Phase 2, Randomised Controlled Trial

Caloric RestrictionHas a New Player

Caloric Restriction in Humans Reveals Immunometabolic Regulators of Health Span

Excerpt from:
Restrict Calories to Boost Immune Function - The Epoch Times

AUSTIN, Texas--(BUSINESS WIRE)--Longevity Partners, the global multi-disciplinary ESG Consultancy, has announced today the expansion of its global footprint with the opening of a new office in Tokyo, Japan. The new office, which is set to open on September 6th, 2022, marks the ninth international office for Longevity Partners since its inception in 2015; joining its other locations in Paris, London, Munich, Amsterdam, Milan, Austin, Seattle and New York.

The expansion comes on the heels of Longevitys recognition as Europes fastest growing ESG advisory firm by the Financial Times and after having doubled its annual revenue for the seventh consecutive year in a row in 2021. In line with Longevity's practice of establishing offices in jurisdictions where clients' needs are the greatest, the new subsidiary will provide local, tailored, and first-class ESG solutions to Longevitys new and existing clients in Japan and beyond.

Etienne Cadestin, Founder and Global CEO said: To respond to fantastic client demand and accelerate our impact in the Asia Pacific region, I am delighted to announce the launch of our Asian headquarters and fully owned subsidiary in Tokyo. We are very excited about our Japanese expansion, the world's third-largest economy.

Though the country is the fifth largest carbon emitter in the world, Japan has a very ambitious emission reduction program to halve its emissions by 2030. Longevity's local team of experts will provide a unique global experience to the local real asset market to meet its climate goals. Our ambition is to create plenty of green jobs and employ more than a hundred people in the next few years in our Tokyo office, to support our partners and accelerate the region's decarbonization efforts.

This latest expansion finalizes our three years globalization program, which means that we can now deliver globally wherever our clients need us. It also marks a milestone for Longevity as we now have boots on the ground in 6 of the G7 countries, representing around 30 percent of the global economy.

I'm also delighted to bring Kemmu on board to lead our efforts in Japan, and we very much look forward to working closely with him in the coming years to deliver our agenda in the Asia Pacific region to secure a more sustainable, inclusive, and low carbon society for future generations!

Kemmu Kawai, the new Country Director of Longevity Partners Japan and Asia, will be responsible for overseeing all of Longevitys activities in the region.

I am thrilled to be joining Longevity and excited to launch the Tokyo office, the first Longevity Partner's Asian office with our professional team members. I will bring to the Longevity team my expertise in real estate in Asia and am looking forward to delivering unique ESG solutions to our local as well as global clients across the Asia Pacific region, says Kemmu Kawai, Longevity Partners Japan Country Director. I am excited to be in this position to contribute to the success of our business and that of our clients.

In recent months, Longevity Partners has undergone a tremendous organizational restructuring, including the expansion of its technical expertise at a global level with the appointment of over 70 new experts since January 2022. At the same time, Longevity Partners has invested heavily in the digitalization of its innovative service solutions and launched new services such as Climate Resilience, Value at Risk, Green Finance, Social Impact, and Net Zero Carbon Portfolio Management. The new opening in Tokyo is designed to fit the rapidly evolving needs of its clients and to better support its partners decarbonization efforts across the Asia Pacific region, giving Longevity the right edge to assert itself as the first truly global independent ESG advisory firm in the real estate sector.

About Longevity Partners

Operating in over 40 countries for more than 100 institutional investors across all asset classes, Longevity Partners provides all services required to future-proof property investment portfolios. From carbon footprinting to climate risk and ESG strategy development and implementation, our experts provide all the tools to respond to ESG performance requirements from pension funds and asset owners. Longevity works hand-in-hand with real estate owners to position their assets for the demands of tomorrow while improving the well-being of users and net operating income today.

The company considers anticipated legislation and achievable benchmarks when improving clients ESG performance. Asset managers must be aware of how they can optimize their assets resiliency to extreme weather events, better manage regulatory risks and improve the quality of their products over time to respond to client demand.

For further information, please visit: https://longevity-partners.com/.

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Longevity Partners Opens Asia Headquarters in Tokyo, Japan - Business Wire

Eating right comes with so many benefitsreducing inflammation, enhancing athletic performance, improving everyday energy, helping bone health, and protecting or controlling chronic diseases like diabetes and cancer. Now we can add one more impressive perk to the list: Healthy eating habits also can extend the length of life and reduce the risk of "all-cause mortality."

All-cause mortality, or all the deaths that occur in a population independent of cause, is of great interest to researchers in solving the puzzle of what habits and interventions provide protection versus risk when it comes to death. Although certain standalone foods aren't going to be the unrealized fountain of youth, there are certain types of foods that, when eaten regularly, are associated with better chances of living a longer life, including foods that can easily make their way onto your plate at breakfast time.

Here are the top seven breakfasts to include in your eating routine to promote longevityand for more inspiration, check out 5 Anti-Inflammatory Breakfasts to Slow Aging.

If you've never hopped on the chia pudding wagon, now is the time. Chia seeds have a unique talent; they become a gel after sitting in a liquid for around 20 minutes or longer. Their other superpowers? Chia seeds have around 11 grams of fiber and 7 grams of unsaturated fat per two-tablespoon serving, and they are a good source of calcium and iron.

Tap into these benefits by mixing chia seeds with low-fat or nondairy milk and a small amount of sweetener like agave nectar, and setting it while covered in the refrigerator overnight. Wake up to a beautiful chia pudding begging for your attention, particularly if you make this Customizable Overnight Chia Pudding recipe.

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A 2021 prospective analysis in the journal Nutrients of 909 participants 60 years and older enrolled in the "Costa Rican Longevity and Healthy Aging Study (CRELES)" found that a marker of biologic aging, leukocyte telomere length (LTL), was positively associated with consumption of grains. The best grains for our diets are whole grains like oats, which include all three layers of the plant.

Try making your oatmeal with old-fashioned oats, fresh apple slices, cinnamon, and no more than a tablespoon of maple syrup for a fresh start to the day.

Well-planned, plant-based diets are connected to a reduced risk of all-cause mortality, according to reports from a 2019 study by the Journal of the American Heart Association. This includes a diet of whole grains, fruits, vegetables, nuts, legumes, tea, and coffee. Hit five of these seven recommended foods with a stacked avocado toast: hearty whole grain bread, a spread of hummus, avocado, and sliced tomato, alongside a hot green tea for sipping.

In a different take on legumes, mix black beans in a skillet with cubed sweet potato, corn, onions, and bell pepper to make a filling potato hash. An egg sunny-side up could be put atop this dish. If serving others in your home, provide whole grain tortillas for family members to stuff to their liking, adding any favorite sauces or herbs they may like.6254a4d1642c605c54bf1cab17d50f1e

Blue Zones, which are the five cultures across the world with the longest-living populations and most centenarians, are studied for their eating patterns, which resemble the Mediterranean diet. We can try replicating some of these choices by getting serious about vegetables at breakfast. Next time you make eggs, scramble them with vegetables like onions, tomatoes, and spinach, for an easy way to get in some produce at your first meal.

Fruits are also a common food consumed in a diet that supports longevity and is part of a Mediterranean-style eating pattern. Smoothies are an outstanding way to enjoy fruit in a form that eliminates any texture turn-offs. Blend up fruits that usually go uneaten in the refrigerator with a low-fat dairy or nondairy milk and pour it into a bowl. (If you have strawberries, mango, and grapes, these make a terrific combo!) Top with a heavy drizzle of natural peanut butter and banana slices to make a yummy, eye-catching breakfast solution.

One last breakfast idea for longevity that incorporates fruit and takes very little prep? Yogurt with blueberries. Select a low-fat yogurt with less than 8 grams of sugar per serving and mix in fresh or frozen blueberries. Then, sprinkle with walnuts or pecans for a perfect on-the-go meal. Take this dish to the next level by alternating layers in a clear mason jar, so your yogurt parfait will entice you even more to finish your meal.

Molly Hembree, MS, RD, LD

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7 Best Breakfast Ideas for Longevity Eat This Not That - Eat This, Not That

The National University Health System (NUHS) establishes the NUHS Centre for Healthy Longevity a world's first integrated pre-clinical and clinical ageing research institute that is poised to lead the Longevity Medicine field with clinical research to prolong healthspan by delay ageing.

The NUHS Centre for Healthy Longevity (NUHS CHL) will initiate, for the first time in a South-East Asian population, clinical research based on 'longevity medicine' or 'geroscience' to target the biggest risk factor for chronic disease, namely, biological age.

The Centre will focus on key geroscience projects, and develop and validate ageing 'clocks' in the Singapore population, and to test the efficacies of novel geroprotectors in delaying biological ageing and enhancing healthspan.

The Centre will develop an integrative pre-clinical laboratory model and clinical human research pipeline that focuses on identifying, and treating biological hallmarks of disease.

Lien Foundation gifts S$5 million to the Centre's research partner, the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), for these research efforts.

SINGAPORE, Sept. 7, 2022 /PRNewswire/ -- Ageing is the climate change in medical science, where global societies are experiencing a sharp rise in the number of older adults relative to the rest of the population. Singapore will be the fastest country by 2025, with 25% of its population estimated to be above 65 years old by 2030. Although medical advancement has improved life expectancy among Singaporeans by 8.7 years to 84.8 years, one of the longest in the world; our healthy life expectancy, or healthspan, increased by only 7.2 years to 74.2 years. The grim reality is that Singaporeans are spending about 10 years of their twilight years in poor health. As the gap between life expectancy and health adjusted life expectancy increases, healthcare and caregiving costs will represent an unsustainable socioeconomic burden for society.

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NUHS Centre for Healthy Longevity

2 NUHS CHL has one clear mission: to enhance healthspan by five years in the Singapore population by slowing biological ageing. Its strategy is to embark on geroscience and longevity medicine-based approaches to achieve this mission. Geroscience and longevity medicine are paradigm-shifting concepts in research and medicine, that acknowledge species-conserved pathways of biological ageing, and view biological ageing as the greatest risk factor for chronic, age-related diseases. Proponents of geroscience/ longevity medicine also advocate the implementation of the use of biomarkers and interventions with the use of artificial intelligence to enhance healthspan.

3 Pre-clinical model organisms have traditionally been used in early pharmaceutical trials, but do not always translate successfully to human trials. NUHS CHL will use age-appropriate models for discovering mechanistic pathways that respond well to novel interventions, called geroprotectors. These treatments will then be translated into clinical human studies of CHL. Both clinical and pre-clinical divisions in the centre work iteratively to identify, refine and implement promising geroprotectors. The South-East Asian population has been traditionally understudied in clinical research. With the three major races, Chinese, Malay and Indian, numbering about 2.5 billion people and accounting for more than a quarter of humanity, results gleaned from the CHL's research will have significant global impact, particularly in Asia.

4 NUHS CHL is also the clinical and translational partner of the Healthy Longevity Translational Research Programme (TRP) at NUS Medicine, whose research to slow ageing, and improve healthspan for the broader population has received generous funding ($5 million) from the Lien Foundation. Termed 'Hacking Ageing', the research initiative comprises three broad themes, which will contribute to the creation of an integrated biomarker-artificial-intelligence (AI) platform that will be the world's first in testing supplements and repurposed drugs combined with lifestyle interventions in the Asian population. This will allow for better early detection, risk stratification and development of personalised, preventive and therapeutic strategies to improve healthspan. Lee Poh Wah, CEO, Lien Foundation said, "Through the 'Hacking Ageing' initiatives, we hope to contribute to the national agenda to shift the healthcare paradigm from the present state of reactive 'sick care' towards a population health prevention approach. Socioeconomic factors are often at the root of health inequalities. As a society, we have a moral duty to ensure anti-ageing therapeutics are not confined to the realm of the rich and exacerbate existing disparities. Developing biomarkers and interventions that are accessible to all in the community, is necessary towards narrowing this gap and democratising healthy longevity. A takeaway from our Gym Tonic programme is that seniors want, and can, get strong on their own terms. Healthspan encompasses not just the physical but the cognitive and emotional dimensions too. We need to mainstream longevity science, and arm everyone with the knowledge and tools to extend the period of life spent in good health."

5 The first research theme funded under the 'Hacking Ageing' initiative is a series of clinical studies to test novel nutritional supplements and repurposed drugs to slow ageing in middle-aged adults (40-60 years). The second research theme is to use deep omics data to personalise these supplements and repurposed drugsand other interventions for optimal healthspan extension in middle-aged participants. The thirdresearch theme focuses on extending healthspan in older adults throughstrength training exercise, harnessing the Foundation's Gym Tonic community of seniors.

6 Professor Brian Keith Kennedy, internationally recognised for his research in the biology of ageing and for his work to translate research discoveries into new ways of delaying, detecting, and preventing human ageing and its associated diseases, is helming the Centre with co-director, Professor Andrea Britta Maier, a geriatrician by training and intensivist of chronic diseases. The 1,600 square feet Centre for Healthy Longevity (CHL) located at Alexandra Hospital and a laboratory at NUSMedicine, will conduct trials and execute validation studies with healthy participants from the age of 30 years old. The Centre will also develop and test these interventions using newly identified biomarkers of human ageing. Once the approaches are validated, the Centre will develop strategies that integrate a combination of nutritional, medicinal and exercise approaches for personalised adoption in the Singapore population. The ultimate goal is to bring the individual closer to his/her state of optimal peak performance during the entire lifespan (e.g. screening to start from 30 years of age).

7 CHL will be looking at blood-based biomarkers, probably the most investigated group due to a large amount of data accumulated in clinical trials.

Genetic markers, meanwhile, reflect predispositions to certain ageing phenotypes, characterised by the prevalence of specific pathological processes and age-related diseases.

One biomarker CHL is looking at is DNA methylation or a DNA methylation "clock", which measures the degree of chemical modification in the human genome to predict biological age.

CHL is also measuring ageing using inflammation markers, metabolomics, and other novel parameters like facial ageing analysis.

8 "Developing new interventions to slow ageing and developing new biomarkers to measure ageing, are what we are trying to do here in Singapore through the new Centre," says Prof Kennedy, "and then, we can recommend inventions to see if they can slowly reverse aspects of ageing in the Asian population." Co-director, Professor Andrea Maier added, "The body's ability to fight diseases reduces dramatically with age. If we can address the physiological changes of ageing, we may be able to slow or stop the onset of disease. In three to five years, healthy longevity will not only exist as a lab-proven concept, but will become part of everyone's life."

She elaborated, "The aim of geroscience is to prevent age-related diseases like the occurrence of dementia, cancer, lung diseases, osteoarthritis or sarcopenia, all the diseases we know of. So next time, tell your GP, your biological age, not your chronological age, for a more targeted, customised and precise prognosis and treatment or intervention plan. This also gives the physician a better association with risk of outcomes one will not want to have like impairment and death."

Anyone who is keen to participate in the above various studies can contact healthy_longevity@nuhs.edu.sg for more information.

Dr Maier, Dr Kennedy, and Dr Goh Jor Ming from NUHS CHL

SOURCE National University Health System (NUHS)

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Prolonging healthspan by delaying ageing -- NUHS opens Singapore's first Centre for Healthy Longevity to increase healthy lifespan of Singapore...