Category Archives: Longevity

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Lifelong engagement key to longevity | Health | The Daily News - Galveston County Daily News

So, Yamamoto knows a thing or two about longevity, particularly what Japanese people with long lives have in common.

LongeviQuest has verified 269 supercentenarians in Japan, including in Okinawa, one of the worlds so-called Blue Zones, where an unusually high number of people live to be over 100.

Like in other Blue Zones, Japans super-agers tend not to eat much meat and spend lots of time with family. But they have other longevity-boosting habits which are more specific to the country, Yamamoto said.

Theres a saying in Japanese, which says you should only eat until youre 80 per cent full, so you should leave space at the end of a meal, Yamamoto said.

The saying, hara hachi bu, helps Japanese people to practice mindful eating and mild calorie restriction, which research suggests reduces inflammation and could be beneficial for longevity, according to animal studies, although more research is needed.

The average daily calorie intake of someone from the Okinawa Blue Zone, for instance, is only about 1,900 less than the 2,000 calories per day that the US Food and Drug Administration recommends.

One of the biggest lessons Yamamoto has learned from her chats with supercentenarians is dont do things to excess, instead do all things in moderation.

She wasnt addicted to it, and she wouldnt drink to excess. This is something that I think is common in Japan. Japanese people eat in a balanced way and they dont eat or drink to excess, she said. And that goes not just for food and drink, but also things like not staying up all night.

Experts agree that enjoying treats in moderation can make healthy eating more sustainable an approach dubbed the 80/20 rule.

In Japan, people take part in whats known as radio gymnastics, Yamamoto said. Since 1928, a radio broadcast has directed listeners in body weight exercises for five minutes a day, and Yamamoto said she tries to do radio gymnastics in the mornings just like Japans super-agers.

Research suggests that doing short bursts of intense physical activity could lower the risk of cancer and heart disease, and therefore improve longevity.

Most Blue Zone super-agers dont go to the gym, and instead incorporate movement into their daily lives whether thats by walking, taking the stairs, or doing group sports to combine socialising with exercise.

Yamamoto said that her great-grandmother was always very regimented in her posture, always maintaining a straight back.

One thing Ive noticed about Japanese supercentenarians and centenarians is that theyre very disciplined and strict on themselves in terms of straight posture, she said.

As humans, we will tend to hunch over a little bit as we get older, but very elderly Japanese people, even until old age, will maintain a very straight posture.

Research suggests that a good posture can minimise strain on the body, prevent pain, and help keep it functioning correctly.

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Eat less, move more and sit up straight: Japans secrets to a super long life - South China Morning Post

Sleep Schedule And Longevity: Why Having A Fixed Schedule Is More Important Than Getting 7-8 Hours Of Sleep? New study suggests that sleeping on time very day may just be more important than getting 7 to 8 hours of sleep.

There have been a lot of new researches and debates surrounding sleep in recent times. We have all heard the age old advice that we should at least get 7 to 8 hours of sleep everyday in order to stay healthy both physically and mentally. While it is important to get adequate restful sleep, researchers say that the time of sleep is also important and may be even more crucial. The most recent study revealed that being consistent with your bedtime may be more important than the number of hours you sleep. Let us see what other findings regarding this awaits us.

The new study report will shock and amaze you at the same time. According to the findings, you can increase you life span if you sleep 6 hours every day but only if you schedule is consistent each day. Keeping a fixed timing to go to bed is more effective for longevity than sleeping 8 or more hours every day, says experts. An erratic sleep schedule means that on some days you sleep at 10 pm, while other days its 12 am or 2 pm or it is different every single day. When you have an erratic schedule such as this, you cannot get restful sleep even if you sleep for 10 hours. It will inevitably be fragmented, poor quality and filled with nightmares.

Our body has a circadian rhythm that it maintains in order to function normally. When we follow a good ad healthy routine, our brain also knows when it is time to be alert and when it is time to relax. If we follow an erratic schedule, it upsets the circadian rhythm and causes an imbalance. Due to this, our brain will feel tired when it is time to work and stay alert and it will be alert when it is time to sleep. If this continues in a person's life for a long time, it will impact their other organs and cause serious diseases and eventually lead to early death. Deep and consistent sleep is very important for your body to be healthy.

All you need to have in life is a little bit discipline and a little determination. First thing to note down is that you CAN do this. This is not rocket science. The first few days of falling back into a schedule may be difficult but after few weeks and months, it will be your normal routine nothing that requires extra effort. So, here's what you do:

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Sleep Schedule And Longevity: Why Having A Fixed Schedule Is More Important Than Getting 7-8 Hours Of Sleep? - TheHealthSite

Conventional wisdom often touts the correlation between physical activity and longevity. However, the Finnish Twins Cohort Study, an extensive research endeavor involving 11,000 same-sex twin pairs, challenges this longstanding belief. While it does affirm the health benefits of regular exercise, the study underscores that the relationship between exercise and lifespan is considerably more complex, intertwined with genetics, social factors, and other lifestyle aspects.

The studys most active participants demonstrated a 24% lower mortality rate than their least active counterparts. However, when factors like smoking, alcohol consumption, and Body Mass Index (BMI) entered the equation, the influence of exercise on longevity diminished. This evidence suggests that while exercise does play a role in extending life, it is not the sole factor. Other lifestyle choices, health conditions, and social factors equally contribute to shaping our lifespan.

Even if its role in longevity may be smaller than once assumed, physical activity undeniably provides immediate health benefits. Regular exercise aids in warding off illnesses and elevating the quality of life. Hence, it remains a crucial component of a healthy lifestyle, regardless of its exact contribution to lifespan extension.

A related study published in the Diabetology & Metabolic Syndrome Journal provides further context to the relationship between exercise and longevity. This research illustrates how physical activity interacts with metabolic syndrome, a cluster of conditions that increase the risk of chronic illnesses. The study discovered that regular exercise had a more profound effect on reducing all-cause mortality risks among patients with metabolic syndrome than those without it. This finding underscores the importance of promoting physical activity, especially among patients with metabolic syndrome.

Another layer to the complex longevity puzzle is the difference between sexes. An article in Experimental Gerontology highlights that, although women typically have a higher life expectancy, they also experience a higher incidence of frailty. Factors contributing to these differences range from lifestyle and psychosocial aspects to chromosomal, genetic, epigenetic, and physiological factors. Recognizing these sex-specific factors is essential for developing effective interventions to mitigate frailty and boost longevity.

The Finnish Twins Cohort Study and related research offer valuable insights into the multifaceted relationship between physical activity and longevity. They underscore the need for a holistic approach to health and well-being. While regular exercise is undeniably important, it is just one piece of the complex longevity puzzle. Lifestyle factors, social environment, genetics, and existing health conditions all play a significant role in our lifespan. To truly support longevity, we need to focus not only on promoting physical activity but also on creating supportive environments and addressing health disparities.

These findings highlight the need for continued research to refine our understanding of health and longevity. By delving deeper into the reasons behind social inequalities in health and lifespan, we can develop strategies to promote health and well-being across all segments of society. Ultimately, a nuanced understanding of the factors influencing longevity can guide us in our quest for a longer, healthier life.

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The Complex Relationship Between Exercise and Longevity: A Holistic Approach - Medriva

Investors are greatly misjudging their longevity, and thats affecting their ability to save for their retirement, suggests the results of a survey published by Jackson National Life Insurance.

The insurer surveyed more than 1,000 investors as part of its Security in Retirement Series, and found that only 12% of them had life span projections in line with the actuarial tables of the Centers for Disease Control and Prevention or the Social Security Administration. About 32% were underpredicting their longevity, while about 60% were overpredicting, according to Glen Franklin, assistant vice president of research, RIA and lead generation strategy for Jackson National Life Distributors.

That puts them at risk for potentially delaying planning on things like long-term care that they would need to attend to and prepare for late in life, thinking theyve got longer to get ready for it than they actually may have, Franklin said.

To have adequate money later in life, its imperative that investors get realistic expectations of how long they think they will live so their resources will last as long as they do.

If you way overestimate life expectancy by a significant amount then you have to spread the assets out over a longer period, and it may impact the ability of the client to live at their desired lifestyle in retirement, Franklin said. If they underestimate, they could find themselves needing to reduce their lifestyle.

There are multiple reasons investors are failing to arrive at the correct longevity number. In most cases, they are not using the proper foundation to reach that number. For instance, 40% of those surveyed said they use the age that their parents passed away as a barometer to predict their life expectancy. But thats not a reliable source of information.

The survey also polled 400 financial professionals, and found a third of them had at least 25% of their clients running the risk of potentially outliving their assets.

Advisors would likely have more accurate projections of their clients longevity. Many plan for their clients to live to the ages of 90 to 95, while their clients were predicting they would live only to about 87, the study found.

Age isnt an easy subject to talk about. But advisors are in good stead to broach the topic because theyre more objective, Franklin explained. They can look at the bigger picture and present relevant facts, including population averages.

The thing about death is nobody knows when its coming, and so you should have a variety of scenarios addressed in the plan, Franklin said.

Advisors can also help investors work through recency biaswhen they allow recent events, such as market turbulence or high inflation, to dictate their long-term decisions.

One of the things the advisor will want to help the client with is expanding perspective and not just considering 12 months ago or up to 24 months ago but thinking about the notion over a 10-year span, Franklin said.

This is the first in the multi-part Security in Retirement Series, which Jackson conducted in partnership with the Center for Retirement Research at Boston College. The firm is set to roll the rest of the study out over the next two years, Franklin said. The first part is the current study on longevity risk. The firm is also conducting research for its next study on inflation risk, which will come out early next year.

The final two studies will be on healthcare risk and market risk; the former will come out late next year and the latter in early 2025.

We at Jackson wanted to be a voice in the conversation for the industry around those risks, Franklin said. We are a for-profit enterprise [and] we feel in this case were delivering value to [advisors] and that will make them more favorably disposed to consider us when they have an annuity-based solution they would like to offer to their clients.

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Investors Misjudging Their Longevity, Jackson Says - FA Mag

Summary: Researchers discovered that reducing the amino acid isoleucine in diets can significantly improve health outcomes in mice.

The study reveals that a low-isoleucine diet led to longer lifespans, leaner bodies, and reduced cancer and prostate problems in mice, despite higher calorie consumption.

The findings suggest that isoleucine intake impacts health beyond its caloric value, offering insights into healthy aging and metabolic processes.

This research could pave the way for new dietary recommendations and treatments aimed at improving human health.

Key Facts:

Source: University of Wisconsin-Madison

Theres a popular saying in some circles that a calorie is a calorie, but science shows that it may not be true. In fact, it may be possible to eat more of some kinds of calories while also improving your health.

We like to say a calorie isnotjust a calorie, says Dudley Lamming, a professor and metabolism researcher at the University of Wisconsin School of Medicine and Public Health.

Different components of your diet have value and impact beyond their function as a calorie, and weve been digging in on one component that many people may be eating too much of.

Lamming is the lead author of a new study in mice,published recently in the journalCell Metabolism,showing that cutting down the amount of a single amino acid called isoleucine can, among other benefits, extend their lifespan, make them leaner and less frail as they age and reduce cancer and prostate problems, all while the mice ate more calories.

Amino acids are the molecular building blocks of proteins, and Lamming and his colleagues are interested in their connection to healthy aging.

In earlier research, data from UWMadisons Survey of the Health of Wisconsin showed the scientists that Wisconsinites with higher body mass index measurements (higher is more overweight or obese) tend to consume more isoleucine, an essential amino acid everyone needs to eat. Isoleucine is plentiful in foods including eggs, dairy, soy protein and many kinds of meat.

To better understand its health effects, Lamming and collaborators from across disciplines at UWMadison fed genetically diverse mice either a balanced control diet, a version of the balanced diet that was low in a group of about 20 amino acids, or a diet formulated to cut out two-thirds of the diets isoleucine. The mice, which began the study at about 6 months of age (equivalent to a 30-year-old person) got to eat as much as they wanted.

Very quickly, we saw the mice on the reduced isoleucine diet lose adiposity their bodies got leaner, they lost fat, says Lamming, while the bodies of the mice on the low-amino-acid diet also got leaner to start, but eventually regained weight and fat.

Mice on the low-isoleucine diet lived longer on average 33% longer for males and 7% longer for females. And, based on 26 measures of health, including assessments ranging from muscle strength and endurance to tail use and even hair loss, the low-isoleucine mice were in much better shape during their extended lives.

Previous research has shown lifespan increase with low-calorie and low-protein or low-amino-acid diets starting in very young mice, says Lamming, whose work is supported by the National Institutes of Health.

We started with mice that were already getting older. Its interesting and encouraging to think a dietary change could still make such a big difference in lifespan and what we call healthspan, even when it started closer to mid-life.

The mice on the low-isoleucine diets chowed down, eating significantly more calories than their study counterparts probably to try to make up for getting less isoleucine, according to Lamming. But they also burned far more calories, losing and then maintaining leaner body weights simply through adjustments in metabolism, not by getting more exercise.

At the same time, Lamming says, they maintained steadier blood sugar levels and male mice experienced less age-related prostate enlargement. And while cancer is the leading cause of death for the diverse strain of mice in the study, the low-isoleucine males were less likely to develop a tumor.

Dietary amino acids are linked to a gene called mTOR that appears to be a lever on the aging process in mice and other animals as well as to a hormone that manages the bodys response to cold and has been considered a potential diabetes drug candidate for human patients. But the mechanism behind the stark benefits of low-isoleucine intake is not well understood. Lamming thinks the new studys results may help future research pick apart causes.

That we see less benefit for female mice than male mice is something we may be able to use to get to that mechanism, he says.

While the results are promising, humans do need isoleucine to live. And winnowing a significant amount of isoleucine out of a diet that hasnt been preformulated by a mouse chow company is not an easy task.

We cant just switch everyone to a low-isoleucine diet, Lamming says. But narrowing these benefits down to a single amino acid gets us closer to understanding the biological processes and maybe potential interventions for humans, like an isoleucine-blocking drug.

The Survey of the Health of Wisconsin showed that people vary in isoleucine intake, with leaner participants tending to eat a diet lower in isoleucine. Other data from Lammings lab suggest that overweight and obese Americans may be eating significantly more isoleucine than they need.

It could be that by choosing healthier foods and healthier eating in general, we might be able to lower isoleucine enough to make a difference, Lamming says.

Funding: This research was funded in part by grants from the National Institutes of Health (AG056771, AG062328, AG081482, AG084156, DK125859, F31AG066311, R01AG062328-03S1, F31AG081115, F31AG082504, T32AG000213, F32AG077916, RF1AG056771-06S1, K01AG059899, R01DK133479, P30DK020579, K12HD101368, R01AA029124, P30 CA014520, P50DE026787, U54DK104310, R01DK131175 and P30CA014520) and the U.S. Department of Veterans Affairs (I01-BX004031).

Author: Chris Barncard Source: University of Wisconsin-Madison Contact: Chris Barncard University of Wisconsin-Madison Image: The image is credited to Neuroscience News

Original Research: Closed access. Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice by Dudley Lamming et al. Cell Metabolism

Abstract

Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice

Low-protein diets promote health and longevity in diverse species. Restriction of the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine recapitulates many of these benefits in young C57BL/6J mice.

Restriction of dietary isoleucine (IleR) is sufficient to promote metabolic health and is required for many benefits of a low-protein diet in C57BL/6J males.

Here, we test the hypothesis that IleR will promote healthy aging in genetically heterogeneous adult UM-HET3 mice.

We find that IleR improves metabolic health in young and old HET3 mice, promoting leanness and glycemic control in both sexes, and reprograms hepatic metabolism in a sex-specific manner. IleR reduces frailty and extends the lifespan of male and female mice, but to a greater degree in males.

Our results demonstrate that IleR increases healthspan and longevity in genetically diverse mice and suggests that IleR, or pharmaceuticals that mimic this effect, may have potential as a geroprotective intervention.

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Key to Longevity in Isoleucine Reduction - Neuroscience News