Category Archives: BioEngineering

The Clemson University CLIA Lab is now offering COVID-19 PCR saliva testing to members of the Clemson community thanks in part to a grant that allowed for expansion provided to the lab from the South Carolina General Assembly. Originally only available to Clemson University Students, Faculty and Staff, the free testing is now accessible to all members of the greater Clemson community in an effort to slow the spread of COVID-19. "I think our goal was to always expand and provide resources for the community," said Clemson University professor of bioengineering and director of the CLIA Lab Delphine Dean. "Now we've opened it up so that folks in the community can come and get tested for free. The university is not it's own little bubble island. We are in the community and it is important for everyone to have access to cheap and accurate testing."The saliva testing is being offered weekdays from 10 a.m. to 4 p.m. at Memorial Stadium and consist of a saliva collection. Test takers that spoke to WYFF News 4 today said the process only took 3 to 5 minutes from entry to exit. "It was easy. Easy to get a QR code, easy to register, easy to park and walk up," Clemson community member Kristina Nelson said after she was tested at Memorial Stadium. "It was very very simple. I was done and in and out in 3 minutes I'm sure.""We thought while it was being offered, why not," Clemson community member Joy Dvoloznak said. "It is an opportunity to get tested and see if anything is wrong basically."The tubes are then taken to the CLIA Lab and analyzed, searching for traces of COVID-19. Dean adds that although the results can be turned around in 6-8 hours in most cases, this is not a "rapid" COVID-19 test and therefore does not have the lack of accuracy that some rapid test methods have. To register for a Clemson University COVID-19 saliva test, click here.

The Clemson University CLIA Lab is now offering COVID-19 PCR saliva testing to members of the Clemson community thanks in part to a grant that allowed for expansion provided to the lab from the South Carolina General Assembly.

Originally only available to Clemson University Students, Faculty and Staff, the free testing is now accessible to all members of the greater Clemson community in an effort to slow the spread of COVID-19.

"I think our goal was to always expand and provide resources for the community," said Clemson University professor of bioengineering and director of the CLIA Lab Delphine Dean. "Now we've opened it up so that folks in the community can come and get tested for free. The university is not it's own little bubble island. We are in the community and it is important for everyone to have access to cheap and accurate testing."

The saliva testing is being offered weekdays from 10 a.m. to 4 p.m. at Memorial Stadium and consist of a saliva collection. Test takers that spoke to WYFF News 4 today said the process only took 3 to 5 minutes from entry to exit.

"It was easy. Easy to get a QR code, easy to register, easy to park and walk up," Clemson community member Kristina Nelson said after she was tested at Memorial Stadium. "It was very very simple. I was done and in and out in 3 minutes I'm sure."

"We thought while it was being offered, why not," Clemson community member Joy Dvoloznak said. "It is an opportunity to get tested and see if anything is wrong basically."

The tubes are then taken to the CLIA Lab and analyzed, searching for traces of COVID-19. Dean adds that although the results can be turned around in 6-8 hours in most cases, this is not a "rapid" COVID-19 test and therefore does not have the lack of accuracy that some rapid test methods have.

To register for a Clemson University COVID-19 saliva test, click here.

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Clemson University CLIA Lab offers free COVID-19 testing to community members - WYFF4 Greenville

Two Caltech faculty members,Lihong WangandChanghuei Yang, have been named fellows of theNational Academy of Inventors(NAI). According to the NAI, election as a fellow is the highest professional distinction accorded to academic inventors who have demonstrated a prolific spirit of innovation in creating or facilitating outstanding inventions that have made a tangible impact on quality of life, economic development and the welfare of society.

Wang, the Bren Professor of Medical Engineering and Electrical Engineering, is focused on biomedical imaging. His lab has developed photoacoustic imaging that allows researchers to see into biological tissues noninvasively, and to peer deeper into the body by nearly two orders of magnitude compared to conventional optical microscopy. Wang has been the recipient of a National Science Foundation CAREER award; and, from the National Institutes of Health (NIH), the FIRST, Directors Pioneer, Directors Transformative Research, and NIH/National Cancer Institute Outstanding Investigator awards.

Wang also received the C.E.K. Mees Medal from the Optical Society of America (OSA), a Technical Achievement Award from the Institute of Electrical and Electronics Engineers (IEEE), an IEEE Biomedical Engineering Award, SPIE Britton Chance Biomedical Optics Award, a Senior Prize from the International Photoacoustic and Photothermal Association, and an OSA Michael S. Feld Biophotonics Award for seminal contributions to photoacoustic tomography and light-speed imaging. He is a fellow of the American Association for the Advancement of Science, the American Institute for Medical and Biological Engineering, the Electromagnetics Academy, the International Academy of Medical and Biological Engineering, and the IEEE, OSA, and SPIE. He is a Foreign Fellow of the Chinese Optical Society. An honorary doctorate was conferred on him by Lund University, Sweden. In 2018, he was inducted into the National Academy of Engineering.

Yang is the Thomas G. Myers Professor of Electrical Engineering, Bioengineering, and Medical Engineering. The Yang lab at Caltech develops technologies aimed at transforming the conventional microscope so that it can be used for high-throughput, automated applications. He also works on the use of time-reversal techniques to undo the effect of tissue light scattering. Yang has received the NSF CAREER Award, Coulter Foundation Early Career Phase I and II Awards, and an NIH Directors New Innovator Award. He is a Coulter Fellow, an AIMBE Fellow, and an OSA Fellow.

Caltech alumni among the 2020 class of NAI fellows include William W. Bachovchin (PhD 77) of Tufts University, Gary A. Evans (MS 71, PhD 75) of Southern Methodist University, and Timothy M. Swager (PhD 88) of MIT. The NAIs 2020 class of fellows includes two Nobel Prize winners, 24 members of the National Academies of Sciences, Engineering, and/or Medicine, and six fellows of the American Academy of Arts and Sciences (AAAS). Collectively, the 2020 class includes the inventors of more than 4,700 U.S. patents.

In 2019, Caltech faculty members Peter B. Dervan, Bren Professor of Chemistry, and Julia A. Kornfield (BS 83), Elizabeth W. Gilloon Professor of Chemical Engineering,were named fellows of the NAI.

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Two Caltech Faculty Members Named to National Academy of Inventors - Pasadena Now

Various diagnostic techniques can be used for sensing the RNA of SARS-CoV-2. Credit: Saadet Alpdagtas and Elif Ilhan

Different diagnostic techniques are appropriate at different stages of coronavirus infection. Using the right one is crucial for rapid diagnosis to help end the pandemic.

Until a vaccine is available, curbing the coronavirus pandemic relies heavily on how quickly a potentially exposed individual can be tested and quarantined. However, the current diagnostic techniques vary in reliability and relevance, so an understanding of which test is most appropriate for a given circumstance is necessary to avoid false reports.

Researchers from Van Yuzuncu Yil University, Marmara University, Yildiz Technical University, and Istanbul Yeni Yuzyil University evaluated the available diagnostic techniques and determined key steps required for better testing moving forward. They present their findings in the journalAPL Bioengineering, from AIP Publishing.

Rapid diagnosis and rapid isolation are the key factors for prevention of the pandemic, said Oguzhan Gunduz, one of the authors.

Laboratory tests that target the viruss genes known as real-time reverse transcription-polymerase chain reaction assays are currently the gold standard for testing. But according to the Food and Drug Administration, these could give false negatives.

These tests depend on the presence of antibodies, which may not have yet been developed in the early stages of infection. Since different antibodies appear at different stages, diagnostic tests must be chosen to target the appropriate immune response based on when an individual is believed to have been infected.

There is not any available single test for the entire stage of the disease, Gunduz said. However, I think it may be possible to detect the attack at any stage of the disease with nano-based sensor technologies.

The group emphasizes point-of-care testing as an urgent objective. These types of tests would help detect the virus on site without the need for laboratory equipment or specialized personnel, eliminating or reducing the wait time between testing and obtaining results.

A quite sensitive test that can measure the existent tiny number of viral particles, or any parameter related to the particle weight, structure, charge, diameter can provide rapid and early diagnosis, said Gunduz.

When asked about the potential for a more comfortable testing method, he stressed that this depends on the sampling method and its sensitivity. A fingertip blood test or a saliva test could potentially be underway, though these have their own drawbacks.

There are such tests, but they come up with accuracy and specificity issues, Gunduz said.

Reference: Evaluation of current diagnostic methods for COVID-19 by Saadet Alpdagtas, Elif Ilhan, Ebru Uysal, Mustafa Sengor, Cem Blent stndag and Oguzhan Gunduz, 1 December 2020, AIP Bioengineering.DOI: 10.1063/5.0021554

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There Many Different COVID-19 Tests Which One to Choose? - SciTechDaily

The great thing about ionic liquids is that every small change you make to their chemistry results in a big change in their properties, said Christine Hamadani, a former graduate student at SEAS and first author of the paper. By changing one carbon bond, you can change whether or not it attracts or repels proteins.

Hamadani is currently a graduate student at Tanners lab at the University of Mississippi.

The researchers coated their nanoparticles with the ionic liquid choline hexenoate, which has an aversion to serum proteins. Once in the body, these ionic-liquid coated nanoparticles appeared to spontaneously attach to the surface of red-blood cells and circulate until they reached the dense capillary system of the lungs, where the particles sheared off into the lung tissue.

This hitchhiking phenomenon was a really unexpected discovery, said Mitragotri. Previous methods of hitchhiking required special treatment for the nanoparticles to attach to red blood cells and even then, they only stayed at a target location for about six hours. Here, we showed 50 percent of the injected dose still in the lungs after 24 hours.

The research team still needs to understand the exact mechanism that explains why these particles travel so well to lung tissue, but the research demonstrates just how precise the system can be.

This is such a modular technology, said Tanner, who plans to continue the research in her lab at University of Mississippi. Any nanoparticle with a surface change can be coated with ionic liquids and there are millions of ionic liquids that can be tuned to have different properties. You could tune the nanoparticle and the liquid to target specific locations in the body.

We as a field need as many tools as we can to fight the immune system and get drugs where they need to go, said Mitragotri. Ionic liquids are the latest tool on that front.

The research was co-authored by Morgan J. Goetz.

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Coated nanoparticles survive immune system and deliver drugs - ScienceBlog.com

Avian influenza vaccines marketis expected to gain market growth at a potential rate of 16.34% in the forecast period of 2020 to 2027. Increasing awareness among the people regarding the availability as well as benefits of avian influenza vaccines which will help in boosting the growth of the market.

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The major players covered in the avian influenza vaccines market report are

Analysis based on

Avian influenza vaccines Market report Synopsis

Global Avian Influenza Vaccines Market Scope and Market Size

Avian influenza vaccines market is segmented on the basis of vaccine type, application, and strain. The growth among segments helps you analyse niche pockets of growth and strategies to approach the market and determine your core application areas and the difference in your target markets.

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Avian Influenza Vaccines Market Country Level Analysis

Avian influenza vaccines market is analysed and market size information is provided by country by vaccine type, application and strain as referenced above.

The countries covered in the avian influenza vaccines market report are U.S., Canada and Mexico in North America, Peru, Brazil, Argentina and Rest of South America as part of South America, Germany, Italy, U.K., France, Spain, Netherlands, Belgium, Switzerland, Turkey, Russia, Hungary, Lithuania, Austria, Ireland, Norway, Poland, Rest of Europe in Europe, Japan, China, India, South Korea, Australia, Singapore, Malaysia, Thailand, Indonesia, Philippines, Vietnam, Rest of Asia-Pacific (APAC) in Asia-Pacific (APAC), South Africa, Saudi Arabia, U.A.E, Kuwait, Israel, Egypt, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA).

North America dominates the avian influenza vaccines market due to rising awareness among the people along with growing number of research and development activities in the region while the Asia-Pacific region is expected to grow at the highest growth rate in the forecast period of 2020 to 2027 due to the rising occurrences ofinfectionalong with increasing dependence on poultry for protein.

Table of Contents:

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Washington State University professors Dan Annie Du, Kris Kowdley, and Yuehe Lin were named as Highly Cited Researchers this year.

The annual list identifies researchers who demonstrated significant influence in their fields through the publication of multiple highly cited papers during the last decade. Their names are drawn from the publications that rank in the top 1% by citations for field and publication year in the Web of Science citation index.

Research professor in the School of Mechanical and Materials Engineering

Du is an innovator in the fields of biomaterials and bioengineering. Her work focuses on using nanomaterials for biosensing and drug delivery as well as immunosensors and microchips for biomarker detection. Earlier this year, she led work on developing a method to detect biomarkers for Alzheimers disease. She has produced more than 300 research papers which have been cited nearly 18,000 times, according to Google Scholar. She is the North American editor of Nanoscience and Nanotechnology Asia and editorial board member of Analytica Chimica Acta, Biosensors; Journal of Biosensors and Bioelectronics; Frontiers in Analytical Chemistry, and Sensors.

Clinical faculty at Elson S. Floyd College of Medicine

Kowdley is an internationally recognized liver disease expert and researcher. He has led several major international clinical trials of new treatments for hepatitis C, hereditary hemochromatosis, primary biliary cholangitis, primary sclerosing cholangitis, and nonalcoholic steatohepatitis. His translational and laboratory research focuses on the role of iron as a co-factor in many liver diseases, ranging from hepatitis C, hemochromatosis to nonalcoholic steatohepatitis. He has developed murine models for nonalcoholic steatohepatitis. Kowdley is the author of more than 450 articles, book chapters, reviews, and commentaries, and his scholarly work has been cited nearly 45,000 times, according to Google Scholar.

Leader in the bioengineering and energy fields

Lins work includes the development of nanomaterials and nanobioelectronic devices for disease diagnosis and drug delivery and catalysts for energy storage and conversion. Earlier this year, Lin and colleagues from LosAlamos National Laboratory published a breakthrough in splitting water into hydrogen and oxygen, an advance which has the potential to make renewable energy more affordable. He has produced more than 500 publications which have been cited more than 57,000 times, according to Google Scholar. Lin is a professor in the School of Mechanical and Materials Engineering and a laboratory fellow at the Pacific Northwest National Laboratory. Lin is a fellow of the National Academy of Inventors, the American Association for the Advancement of Science, American Institute of Medical and Biological Engineering, Electrochemical Society, and Royal Society of Chemistry as well as an elected member of the Washington State Academy of Sciences.

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Three WSU professors honored as 2020 Highly Cited Researchers - WSU News