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Texas Science Flap Cited as California Stem Cell Agency Eyes its Own Processes

Posted: October 28, 2012 at 7:49 am


OAKLAND, Ca. – Meeting against a
backdrop from Texas that involves conflicts of interest and mass
resignations of grant reviewers, a task force of the $3 billion
California stem cell agency today began a partial examination of its
own grant approval process, specifically focusing on appeals by
rejected applicants.

The president of the California
organization, Alan Trounson, told the task force that it was dealing
with a “very serious matter” that in some ways is similar to what
happened in Texas. He said the science community is “very much
concerned.”
The situation in Texas involves the
five-year-old Cancer Prevention and Research Institute, which like
the California stem cell agency, formally known as the California
Institute of Regenerative Medicine (CIRM)
, has $3 billion of borrowed
money to use to finance research.
The chief scientific officer of the
Texas organization, Nobel laureate Alfred Gilman, resigned Oct. 12
during a flap about its attempts “to simultaneously support basic
research and nurture companies.”
Gilman's departure was triggered by a
$20 million award made without scientific review. Reviewer
resignations followed with letters that accused the Texas group of
“hucksterism” and dishonoring the peer review process. (Writer Monya Baker has a good overview today in Nature.)
The situation in Texas came to a head
AFTER the governing board of the California research group created
its task force. The problems in Texas are bigger and not identical to
those in California, which mainly involve the free-wheeling nature of the appeal process, not an entire lack of scientific review.
Nonetheless, this past summer, directors of the California agency for
the first time approved an award that was rejected twice by
reviewers. The award went to StemCells, Inc., of Newark, Ca., which
now has won $40 million, ranking the company No. 1 in
awards to business from CIRM.
Earlier this month, Los Angeles Times
business columnist Michael Hiltzik characterized the StemCells, Inc.,
award as “redolent of cronyism.”
Today's session of the CIRM task force
focused primarily on an aspect of the agency's appeals process that
CIRM labels as “extraordinary petitions.” They are letters which
rejected applicants use to challenge decisions by grant reviewers.
The researchers follow up with public appearances before the
governing board, often trailing squads of patients making emotional
appeals.
Both researchers and patients have a
right under state law to appear before the CIRM board to discuss any
matter. CIRM, however, is trying to come up with changes in the
appeal process that will make it clear to researchers on what the
grounds the board might overturn reviewers' decisions. The agency is
also defining those grounds narrowly and aiming at eliminating
appeals based on differences in scientific opinion.
At today's meeting, CIRM Director Jeff
Sheehy
, a patient advocate and co-vice chair of the grants review
group, said peer review is an “extraordinary way of analyzing
science, but it is not always perfect.” However, he also said that
“as a board we are not respecting input” from scientists and thus
allow the perception that we can be “persuaded against the judgment
of scientists.”
CIRM Director Oswald Steward, director
of the Reeve-Irvine Research Center at UC Irvine, agreed with a
suggestion by Sheehy that board must act with “discipline” when
faced with appeals by rejected applicants. Steward said, 

“The
process has gotten a little out of hand.”

It was a sentiment that drew no dissent
at today's 90-minute meeting.
Missing from today's meeting, which had
teleconference locations in San Francisco, Irvine, La Jolla and Palo
Alto, were any of the hundreds of California scientists whose
livelihoods are likely to be affected by changes in the grant
approval process. Also absent were California biotech businesses,
along with the only representative on the task force from CIRM's
scientific reviewers.
Our comment? When researchers and
businesses that have millions at stake fail to show up for key
sessions that set the terms on how they can get the money, it is a
sad commentary on their professional and business acumen.
Bert Lubin, a CIRM director and
chairman of the task force, indicated he would like to have two more
meetings of the task force prior to making recommendations to a full
board workshop in January with possible final action later that
month. Lubin, CEO of Children's Hospital in Oakland, said the matter
is “really important for the credibility of our whole
organization.”

Source:
http://feedproxy.google.com/~r/blogspot/uqpFc/~3/A3HGGTzzso8/texas-science-flap-cited-as-california.html

Recommendation and review posted by Fredricko

Top medicine articles for October 2012

Posted: October 28, 2012 at 7:45 am

Here are my suggestions for some of the top articles in medicine for October 2012:

Worldwide, 31% of adults are physically inactive, ranging from 17% in southeast Asia to 43% in Americas and eastern Mediterranean. The proportion of 13-15-year-olds doing fewer than 60 min of moderate physical activity per day is 80% http://goo.gl/3W6os -- The pandemic of physical inactivity: Physical inactivity is the fourth leading cause of death worldwide - The Lancet http://goo.gl/dL2uE -- Elimination of physical inactivity would increase the life expectancy of the world's population by 7 months http://goo.gl/mbUos -- Why are some people physically active and others not? Genetic factors contribute to propensity to be physically active http://goo.gl/jHuIk -- Evidence-based intervention in physical activity: lessons from around the world - The Lancet - http://goo.gl/eHniD

Snorkelling-related deaths in Australia: cardiac, surface drowning, drowning after prolonged breath-hold diving, trauma http://goo.gl/VT0Bs

Nearly half of U.S. doctors struggle with burnout: study http://goo.gl/T3fnx

Proton-pump inhibitors (PPIs) are associated with increased risk for Clostridium difficile infection http://goo.gl/wLi5v

Interactive atlas by CDC shows data about HIV, AIDS, hepatitis, TB, chlamydia, gonorrhea, syphilis http://goo.gl/aizZS and http://goo.gl/VYztM

Looking at human beings as ecosystems of collaborating/competing species could change practice of medicine http://goo.gl/3LX9R

Prevalence of Celiac Disease in U.S.: 0.7% (1 in 141), rare among minorities but affects 1% of non-Hispanic whites http://goo.gl/1qFwE

Future doctors will need to correct the postmodern tendency toward immune dysregulation http://nyti.ms/SG6nX7

The Search for a Baldness Cure: Vitamin D to Coax Dormant Follicles to Grow Hair http://goo.gl/82s4a

YouTube for information on rheumatoid arthritis - at least 30% of videos were misleading. A wakeup call? http://goo.gl/Rjzdv

From physician frustration to physician satisfaction. "Oh we’re not gonna take it anymore", sings AMA http://goo.gl/SSWdQ

6 tips for marketing a practice outside social media - amednews http://goo.gl/AwGZ8

Many hospitals recruiting doctors continually. Contact them even if there isn't a job listing, say experts http://goo.gl/v8Oy7

EHR Report 2012: Physicians Rank Top EHRs http://buff.ly/QHeMqU

The articles were selected from my Twitter and Google Reader streams. Please feel free to send suggestions for articles to clinicalcases@gmail.com and you will receive acknowledgement in the next edition of this publication.

Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook.


Source:
http://feedproxy.google.com/~r/CasesBlog/~3/DOI1TaJYPdI/top-medicine-articles-for-october-2012.html

Recommendation and review posted by G. Smith

Alopecia: Gita’s story

Posted: October 28, 2012 at 7:45 am

NHSChoices: Hair loss, or alopecia, affects an estimated 8 million women in the UK. In this video Gita Mendis talks about her experience of alopecia areata, how she felt when she noticed her hair loss and the treatment she received.

http://www.youtube.com/watch?v=L5dp2t1JZXE

Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook.


Source:
http://feedproxy.google.com/~r/CasesBlog/~3/yqhHfP_3jsE/alopecia-gitas-story.html

Recommendation and review posted by G. Smith

ChemCoach carnival – an ear to the ground and a finger in every pie

Posted: October 28, 2012 at 7:45 am

My mugshot, for those who want to put a face to the name

In response to SeeArrOh’s ChemCoach carnival call, here is an insight into my small part as a cog in the inner workings of Chemistry World towers.

Your current job
I am one of two staff Science Correspondents for Chemistry World magazine. I am responsible for writing news and feature articles covering the whole range of chemistry research, industry, policy etc. I also edit two of our regular columns – Classic kit from the excellent Andrea Sella, and Totally synthetic, written by Paul Docherty (who some of you may know was once my lab- and flat-mate. It’s great when you can keep in touch with friends through your daily work.)

What you do in a standard “work day”
Like Carmen and a lot of others have mentioned, the nature of my role is very fluid. I can be writing and researching articles on anything from Rydberg atoms to Nobel prizes from one day to the next. That means I get to meet and speak to all sorts of interesting people, from the top researchers and industrialists around the world, to politicians and policymakers.

My usual day is spent hunting for news stories in journals and other sources (I read way more journals now than I ever did as a student), before our daily news meeting where we decide what we’re going to cover from what’s been found that day. Then I’ll be writing, researching or editing my latest pieces.

What kind of schooling / training / experience helped you get there?
I have a MSci in Natural Sciences (specialising in chemistry but including materials science, cell biology and pharmacology) from the University of Cambridge, and a PhD (or DPhil if you’re going to be picky) in synthetic organic chemistry from the University of Oxford. During my undergrad degree I spent time in both analytical and synthetic labs in industry, with a view to a career in med chem, which gave me a tiny insight into how Pharma works.

I have no formal training in journalism, but during my PhD I entered (and somehow managed to win) a writing competition run by the Daily Telegraph newspaper. On the back of that I did a bit more writing for the Telegraph and a few other places, which made me think I should consider it more seriously as a career. After writing up, I joined the Royal Society of Chemistry in Cambridge in a graduate communications role, and was fortunate that a job on Chemistry World came up a few months later.

How does chemistry inform your work?
Every day I am reading, writing and trying to understand chemistry of some kind. While my knowledge of the gamut of organic transformations may have dwindled, my general chemistry is stronger than ever, and I am constantly learning about new topics and applying my chemical understanding to see where they fit in to the bigger picture.

I also teach first year undergraduate chemistry one night a week in Cambridge, which is a great way to keep my basic chemistry ticking over.

Finally, a unique, interesting, or funny anecdote about your career
During my PhD, which I began in Cambridge, my supervisor was offered a permanent lecturer position at Oxford. This meant we needed to move the whole lab from one university to another. While Jon is quite a young group leader, we were fortunate enough to have inherited a reasonably large stock of chemicals and equipment from his former supervisor, who had emigrated to Australia. But that meant we had to transport it all.

My boss got some professional quotes for the move, but the £30k quote was somewhat above our budget, so we hired a couple of vans and loaded up for a group outing cross country. Luckily, my father could advise on the legalities of transporting chemicals, so we packed up pretty much everything that wasn’t pyrophoric, explosive, highly oxidising, overly smelly, strongly alkylating or otherwise likely to cause problems in the event of an accident, and trundled off.

There were, of course, plenty of surprises when clearing out the cupboards and fridges. Arcane glassware that not even the venerable technicians could identify, useful stuff we never knew we had, not to mention the two litre bottle of phosgene in toluene solution…

Digg This  Reddit This  Stumble Now!  Share on Facebook  Bookmark this on Delicious  Share on LinkedIn  Bookmark this on Technorati  Post on Twitter  Google Buzz (aka. Google Reader)  

Source:
http://prospect.rsc.org/blogs/cw/2012/10/26/chemcoach-carnival-an-ear-to-the-ground-and-a-finger-in-every-pie/

Recommendation and review posted by G. Smith

Chemistry in its element – Graphene

Posted: October 28, 2012 at 7:45 am

With potential uses from solar cells, transparent speakers, tranisistors and more, it’s no wonder graphene is called a wonder-material. Find out all about it in this week’s Chemistry in its element

Digg This  Reddit This  Stumble Now!  Share on Facebook  Bookmark this on Delicious  Share on LinkedIn  Bookmark this on Technorati  Post on Twitter  Google Buzz (aka. Google Reader)  

Source:
http://prospect.rsc.org/blogs/cw/2012/10/24/chemistry-in-its-element-graphene/

Recommendation and review posted by G. Smith

Grey’s Anatomy Photo Preview: "Beautiful Doom"

Posted: October 28, 2012 at 7:45 am

Grey's Anatomy returns Thursday, November 8 with "Beautiful Doom," an installment that will find a young woman in peril after getting trapped under a car and Meredith Grey desperate to save her life.

This case, clearly, hits close to home for the show's titular character.

Mer and Lil Zola

This is just half of the Meredith & Cristina-centric episode, which features the two friends continuing to cope with life after the plane crash and their ever-growing responsibilities at their respective hospitals.

As Meredith juggles taking care of Zola during the aforementioned crisis, Cristina assists Dr. Thomas on a challenging heart surgery, as seen in ABC's first Grey's Anatomy promo for the show's return.

Click to enlarge images from "Beautiful Doom" and comment below:

Hi! Over Here!The Smiling Callie3 New FacesGaius Charles on Grey's3 Fresh FacesA Jo PicGrey's N00bTake This CutieCallie and BabyBaby in TowMandy Bailey PicDr. Mer Grey PhotoA Mer Grey PicMer and BaileyMer, Owen and ZolaGreen Scrubbing InSmiling Callie


Source:
http://www.tvfanatic.com/2012/10/greys-anatomy-photo-preview-beautiful-doom/

Recommendation and review posted by G. Smith


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