Category Archives: Resveratrol

Oh, the giddy abandon that overtakes some headline writers when crowning a story about resveratrol, a chemical found in red wine. Heres a sampling of the latest:

All that for an article published today in the journal Cell suggesting that resveratrol blocks the action of a muscle enzyme called phosphodiesterase 4 in mice. Dont get me wrong: its interesting research, that couldemphasis on couldopen the door someday to new treatments for heart disease, diabetes, memory loss, and other chronic conditions. But it doesnt merit the hype that comes with almost any new research on resveratrol.

Resveratrol is a compound that various plants make to fight off bacteria, fungi, and other microbial attackers, or to withstand drought or lack of nutrients. It has been found in red and purple grapes, blueberries, cranberries, mulberries, lingonberries, peanuts, and pistachios. Resveratrol is also abundant in the roots of Japanese knotweed, a plant that has become a hard-to-eradicate invader in the United States.

In 1992, two Cornell University plant scientists suggested that resveratrol might be responsible for the cardiovascular benefits of red wine. Since then, hundreds of reports have indicated that resveratrol mayemphasis on mayprotect against cancer, cardiovascular disease, vascular dementia, and Alzheimers disease, and extend the life span.

Exactly how resveratrol might do all this is still a mystery. One possibility is that it turns on genes that make sirtuins, ancient proteins found in virtually all species. Activating sirtuins kicks off a response that fights disease and prolongs life. The Cell researchers were trying to figure out just how resveratrol might turn on sirtuin genes.

Virtually all of the positive studies on resveratrol have come from cultures of cells or laboratory experiments with yeast, roundworms, fruit flies, the short-lived turquoise killifish, or mice. The few human studies have looked at specific intermediate markers, such as levels of antioxidants, heart rate variability, blood flow to the brain, and amounts of cancer proteins. None have measured long-term health or survival.

Another big unknown is side effects. Resveratrol acts on many different tissues in the body. It is chemically related to estrogen. In some situations, high doses of resveratrol boost the activity of estrogen, in others they block estrogen. That makes resveratrol supplements iffy for women with cancer of the breast, ovary, uterus, or other estrogen-sensitive tissue, those trying to become pregnant, or those taking an oral contraceptive.

Resveratrol makes platelets in the bloodstream less sticky, and so could increase the risk of bleeding in people who take warfarin (Coumadin), clopidogrel (Plavix), aspirin, ibuprofen, or other nonsteroidal anti-inflammatory drugs.

Another cloud: a company called Sirtris Pharmaceuticals, which was established to develop drugs from resveratrol, pulled the plug on the program in 2010 when a clinical trial showed that one of these drugs might be linked to kidney damage.

If you believe that resveratrol will help you live longer and healthier, get it from food or wine, not by choking down resveratrol pills. Why? Eating red grapes, blueberries, and pistachios, or having a glass of your favorite red wine, are pleasurable ways to take in resveratrol. Plus you get all the other healthful plant products that come with the resveratrol. Getting it via supplement is dull, and you cant always trust what you are getting. If you choose to take a supplement, shop carefully. A review by the independent ConsumerLab found that one brand cost just 15 cents per 100 milligrams of resveratrol, while another cost $2.76 per 100 milligrams.

Its worth keeping an eye on resveratrol research. But its far too soon to be promoting it as a fountain of youth or wonder drug.

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Resveratrolthe hype continues - Harvard Health Blog ...

Sirtuins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity.[2][3][4][5][6] Sirtuins regulate important biological pathways in bacteria, archaea and eukaryotes. The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2',[7] the gene responsible for cellular regulation in yeast.

Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation[8] and stress resistance, as well as energy efficiency and alertness during low-calorie situations.[9] Sirtuins can also control circadian clocks and mitochondrial biogenesis.

Yeast Sir2 and some, but not all, sirtuins are protein deacetylases. Unlike other known protein deacetylases, which simply hydrolyze acetyl-lysine residues, the sirtuin-mediated deacetylation reaction couples lysine deacetylation to NAD hydrolysis. This hydrolysis yields O-acetyl-ADP-ribose, the deacetylated substrate and nicotinamide, itself an inhibitor of sirtuin activity. The dependence of sirtuins on NAD links their enzymatic activity directly to the energy status of the cell via the cellular NAD:NADH ratio, the absolute levels of NAD, NADH or nicotinamide or a combination of these variables.

Whereas bacteria and archaea encode either one or two sirtuins, eukaryotes encode several sirtuins in their genomes. In yeast, roundworms, and fruitflies, sir2 is the name of one of the sirtuin-type proteins (see table below).[10] This research started in 1991 by Leonard Guarente of MIT.[11][12] Mammals possess seven sirtuins (SIRT17) that occupy different subcellular compartments such as the nucleus (SIRT1, -2, -6, -7), cytoplasm (SIRT1 and SIRT2) and the mitochondria (SIRT3, -4 and -5).

The first sirtuin was identified in yeast (a lower eukaryote) and named sir2. In more complex mammals, there are seven known enzymes that act in cellular regulation, as sir2 does in yeast. These genes are designated as belonging to different classes (I-IV), depending on their amino acid sequence structure.[13][14] Several Gram positive prokaryotes as well as the Gram negative hyperthermophilic bacterium Thermotoga maritima possess sirtuins that are intermediate in sequence between classes and these are placed in the "undifferentiated" or "U" class.[13] In addition, several Gram positive bacteria, including Staphylococcus aureus and Streptococcus pyogenes, as well as several fungi carry macrodomain-linked sirtuins (termed "class M" sirtuins).[6] Most notable, the latter have an altered catalytic residue, which make them exclusive ADP-ribosyl transferases.

Sirtuin list based on North/Verdin diagram.[17]

Sirtuin activity is inhibited by nicotinamide, which binds to a specific receptor site,[18] so it is thought that drugs that interfere with this binding should increase sirtuin activity. Development of new agents that would specifically block the nicotinamide-binding site could provide an avenue for development of newer agents to treat degenerative diseases such as cancer, diabetes, atherosclerosis, and gout.[19][20]

Sirtuins have been proposed as a therapeutic target for type II diabetes mellitus.[21]

Preliminary studies with resveratrol, a possible SIRT1 activator, have led some scientists to speculate that resveratrol may extend lifespan.[22] Further experiments conducted by Rafael de Cabo et al. showed that resveratrol-mimicking drugs such as SRT1720 could extend the lifespan of obese mice by 44%.[23] Comparable molecules are now undergoing clinical trials in humans.

Cell culture research into the behaviour of the human sirtuin SIRT1 shows that it behaves like the yeast sirtuin Sir2: SIRT2 assists in the repair of DNA and regulates genes that undergo altered expression with age.[24] Adding resveratrol to the diet of mice inhibit gene expression profiles associated with muscle aging and age-related cardiac dysfunction.[25]

A study performed on transgenic mice overexpressing SIRT6, showed an increased lifespan of about 15% in males. The transgenic males displayed lower serum levels of insulin-like growth factor 1 (IGF1) and changes in its metabolism, which may have contributed to the increased lifespan.[26]

SIRT1, SIRT6 and SIRT7 proteins are employed in DNA repair.[27] SIRT1 protein promotes homologous recombination in human cells and is involved in recombinational repair of DNA breaks.[28]

SIRT6 is a chromatin-associated protein and in mammalian cells is required for base excision repair of DNA damage.[29] SIRT6 deficiency in mice leads to a degenerative aging-like phenotype.[29] In addition, SIRT6 promotes the repair of DNA double-strand breaks.[30] Furthermore, over-expression of SIRT6 can stimulate homologous recombinational repair.[31]

SIRT7 knockout mice display features of premature aging.[32] SIRT7 protein is required for repair of double-strand breaks by non-homologous end joining.[32]

These findings suggest that SIRT1, SIRT6 and SIRT7 facilitate DNA repair and that this repair slows the aging process (see DNA damage theory of aging).

Excerpt from:

Sirtuin - Wikipedia

ResveratrolChemical structures of cis- ((Z)-resveratrol, left) and trans-resveratrol ((E)-resveratrol, right)[1]NamesOther names

trans-3,5,4-Trihydroxystilbene;3,4,5-Stilbenetriol;trans-Resveratrol;(E)-5-(p-Hydroxystyryl)resorcinol;(E)-5-(4-hydroxystyryl)benzene-1,3-diol

Oc2ccc(C=Cc1cc(O)cc(O)c1)cc2

Resveratrol (3,5,4-trihydroxy-trans-stilbene) is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi.[5][6] Sources of resveratrol in food include the skin of grapes, blueberries, raspberries, mulberries.[7]

Although it is used as a dietary supplement, there is no good evidence that consuming resveratrol affects life expectancy or human health.[8][9]

There is no evidence of benefit from resveratrol in those who already have heart disease.[10] A 2014 Chinese meta-analysis found weak evidence that high-dose resveratrol supplementation could reduce systolic blood pressure.[11]

As of 2016[update], there is no evidence of an effect of resveratrol on cancer in humans.[12]

There is no conclusive human evidence for an effect of resveratrol on metabolism.[13][14]

There is no evidence for an effect of resveratrol on lifespan in humans as of 2011[update].[15]

In 2010, GlaxoSmithKline suspended a small clinical trial of SRT501, a proprietary form of resveratrol, due to safety concerns, and terminated the study later that year. SRT501 was composed of microparticles (< 5 m) intended to enhance absorption and was delivered at a dose 5 grams per day, causing gastrointestinal disorders and diarrhea in many subjects.[16] Although limited human studies have shown resveratrol is well-tolerated,[11][14] one clinical study of Alzheimer's disease patients showed there were side effects from daily intake of up to 2 grams, including nausea, diarrhea, and weight loss.[17]

Although in vitro studies indicate resveratrol activates sirtuin 1[18] and PGC-1, and affects functioning of mitochondria,[19] other research disputes this effect.[20][21]

In cells treated with resveratrol, an increase is observed in the action of MnSOD (SOD2)[22] and in GPER activity.[23]

One way of administering resveratrol in humans may be buccal delivery, that is without swallowing, by direct absorption through tissues on the inside of the mouth. When one milligram of resveratrol in 50 ml 50% alcohol/ water solution was retained in the mouth for one minute before swallowing, 37ng/ml of free resveratrol was measured in plasma two minutes later. This level of unchanged resveratrol in blood can only be achieved with 250mg of resveratrol taken in a pill form.[24] However, the viability of a buccal delivery method is called into question due to the low aqueous solubility of the molecule. For a drug to be absorbed transmucosally it must be in free-form or dissolved.[25][26] Resveratrol fits the criteria for oral transmucosal dosing, except for this caveat. The low aqueous solubility greatly limits the amount that can be absorbed through the buccal mucosa. Resveratrol that is attempted to be taken buccally was expected to pass through the mucous membrane of the mouth and be absorbed as an oral dose,[27] however, the need to explore buccal delivery in future pharmaceutical formulations was expressed.[26][28]

While 70% of orally administered resveratrol is absorbed, its oral bioavailability is approximately 0.5% due to extensive hepatic glucuronidation and sulfation.[29] Resveratrol given in a proprietary formulation SRT-501 (3 or 5 g), developed by Sirtris Pharmaceuticals, reached five to eight times higher blood levels. These levels did approach the concentration necessary to exert the effects shown in animal models and in vitro experiments.[30]

In rats, less than 5% of the oral dose was observed as free resveratrol in blood plasma.[31] There is a hypothesis that resveratrol from wine could have higher bioavailability than resveratrol from a pill.[32]

In a human study involving oral administration of 500mg over 13 weeks, resveratrol was detected in cerebrospinal fluid, indicating that it had crossed the blood-brain barrier.[17]

Resveratrol gets extensively metabolized in the body, with the liver and lungs as the major sites of its metabolism.[33]

Resveratrol (3,5,4'-trihydroxystilbene) is a stilbenoid, a derivative of stilbene.

It exists as two geometric isomers: cis- (Z) and trans- (E), with the trans-isomer shown in the top image. The trans- and cis-resveratrol can be either free or bound to glucose.[34]

The trans- form can undergo isomerization to the cis- form when exposed to ultraviolet irradiation,[35] a process called photoisomerization:[36]

One study showed that ultraviolet irradiation to cis-resveratrol induces further photochemical reaction, producing a fluorescent molecule named "Resveratrone".[37]

Trans-resveratrol in the powder form was found to be stable under "accelerated stability" conditions of 75% humidity and 40C in the presence of air.[38] The trans isomer is also stabilized by the presence of transport proteins.[39] Resveratrol content also was stable in the skins of grapes and pomace taken after fermentation and stored for a long period.[40]lH- and 13C-NMR data for the four most common forms of resveratrols are reported in literature.[34]

Resveratrol is produced in plants by the action of the enzyme, resveratrol synthase.[41]

The grapevine fungal pathogen Botrytis cinerea is able to oxidise resveratrol into metabolites showing attenuated antifungal activities. Those include the resveratrol dimers restrytisol A, B, and C, resveratrol trans-dehydrodimer, leachinol F, and pallidol.[42] The soil bacterium Bacillus cereus can be used to transform resveratrol into piceid (resveratrol 3-O-beta-D-glucoside).[43]

Resveratrol is a phytoalexin, a class of compounds produced by many plants when they are infected by pathogens or physically harmed by cutting, crushing, or ultraviolet radiation.[44]

Plants that synthesize resveratrol include knotweeds, pine trees including Scots pine and Eastern white pine, grape vines, peanut plants, cocoa bushes, and Vaccinium shrubs that produce berries, including blueberries, raspberries, mulberries, cranberries, and bilberries.[5][7][44]

The levels of resveratrol found in food varies considerably, even in the same food from season to season and batch to batch.[5]

In a 2007 review of published resveratrol concentrations, the average in red wines is 69941899999999999991.91.7mg trans-resveratrol/L (70008199999999999998.27.5M, ranging from nondetectable levels to 14.3mg/l (62.7M) trans-resveratrol. Levels of cis-resveratrol follow the same trend as trans-resveratrol.[46]

In general, wines made from grapes of the Pinot Noir and St. Laurent varieties showed the highest level of trans-resveratrol, though no wine or region can yet be said to produce wines with significantly higher concentrations than any other wine or region.[46]Champagne and vinegar also contain appreciable levels of resveratrol.[45]

Red wine contains between 0.2 and 5.8mg/l, depending on the grape variety. White wine has much less because red wine is fermented with the skins, allowing the wine to extract the resveratrol, whereas white wine is fermented after the skin has been removed.[5] The composition of wine is different from that of grapes since the extraction of resveratrol from grapes depends on the duration of the skin contact, and the resveratrol 3-glucosides are in part hydrolysed, yielding both trans- and cis-resveratrol.[5]

Ounce for ounce, peanuts have about 25% as much resveratrol as red wine.[5]Peanuts, especially sprouted peanuts, have a content similar to grapes in a range of 2.3 to 4.5g/g before sprouting, and after sprouting, in a range of 11.7 to 25.7g/g, depending upon peanut cultivar.[44][45]

Mulberries (especially the skin) are a source of as much as 50 micrograms of resveratrol per gram dry weight.[47]

There are no studies to show that resveratrol supplements are beneficial in humans.[48][49][50] Sales of resveratrol supplements increased in 2006 after studies on non-humans.[48]

Harvard University scientist and professor David Sinclair co-founded Sirtris Pharmaceuticals, the initial product of which was a resveratrol formulation;[51] Sinclair became known for making statements about resveratrol like: (It's) as close to a miraculous molecule as you can find.... One hundred years from now, people will maybe be taking these molecules on a daily basis to prevent heart disease, stroke, and cancer.[52] Most of the anti-aging field was more cautious, especially with regard to what else resveratrol might do in the body and its lack of bioavailability.[52][53]

Sinclair and others obtained significant news coverage about resveratrol.[54][55] Sinclair is often quoted and pictured in online ads for resveratrol supplements, many of which implied endorsement of the advertised product even though Sinclair had not endorsed them.[56]

Supplements vary in purity and can contain anywhere from 50 percent to 99 percent resveratrol.[citation needed]

The first mention of resveratrol was in a Japanese article in 1939 by Michio Takaoka, who isolated it from Veratrum album, variety grandiflorum, and later, in 1963, from the roots of Japanese knotweed.[44][57][58][59]

A 2011 systematic review of existing resveratrol research demonstrated there was not enough evidence to demonstrate its effect on longevity or human diseases, nor could there be recommendations for intake beyond the amount normally obtained through dietary sources, estimated as being less than 4 mg/day.[8] Much of the research showing positive effects has been done on animals, with insufficient clinical research on humans.[8] Resveratrol research in animals and humans remains active.[60][61]

As of 2014[update], the results of studies on laboratory animals or human clinical trials concerning the effects of resveratrol on cancer are inconsistent,[12] even if massive doses of resveratrol are used.[62]

A preliminary, one-year clinical trial of subjects with Alzheimer's disease showed that consuming 2 grams of resveratrol daily was well-tolerated and reduced some disease biomarkers in cerebrospinal fluid and blood, although other biomarkers and progressive dementia were unaffected.[17] Other preliminary human studies indicated that short-term ingestion of resveratrol increased cerebral blood flow in normal subjects[63] and in people with diabetes.[64] Resveratrol is under study for its potential to limit secondary damage after ischemic stroke or acute brain trauma.[65]

Although moderate drinking of red wine is generally associated with reduced risk of heart disease,[66] an association known as "the French paradox",[67] there is little evidence that resveratrol in red wine may have a role in this possible effect.[68]

Animal studies are being conducted to discern potential metabolic and antidiabetic effects of resveratrol.[69] In vitro, resveratrol was shown to act as an agonist of Peroxisome proliferator-activated receptor gamma, a nuclear receptor under pharmacological research as a potential treatment for type 2 diabetes.[70] Although one systematic review and meta-analysis noted that resveratrol is a "leading candidate" compound for serving as an adjunct pharmacotherapy for type 2 diabetes,[71] there is little evidence for its use as a possible treatment for diabetes.[69]

Despite considerable in vitro and animal research, there is no evidence that resveratrol taken orally or topically has any effect on human skin.[72] Preliminary studies have been conducted on resveratrol to understand its potential as a therapy for melanoma.[73][74]

Original post:

Resveratrol - Wikipedia

What Is Resveratrol?

It is a compound found naturally in foods such as grapes, nuts, red wine, peanuts, some berries, and possibly in other fruits and plants. As a result of the large amount of publicity about the French Paradox Study discussed on the website, researchers investigating the potential positive effects of red wine consumption eventually focused on resveratrol, one of the substances found in red wine. Other studies followed and the research continues today

Click Here To See The #1 Top Rated Best Value Resveratrol

Selecting the highest quality supplement is not easy. The science and research is exciting, but new. There has been some excellent work done by many researchers on the potential health benefits, and we have included a number of videos on this site in unedited form and in full for you to examine. Its very impressive stuff, but we let the real experts do the talking. So, we dont extrapolate their views and delve into hype like you will see on most of the other websites. Please view those videos right here on this website. They are loaded with unbiased, non-commercial information from scientists, researchers and experts.

If you decide that supplementation is right for you, then the problem becomes choosing the best supplement. Thats not so easy and we hope to help.

Click Here To See The #1 Top Rated Best Value Resveratrol

Check out the page titled Resveratrol Benefits and watch the highly informative story on 60 Minutes on this website, as well as the in-depth interviews of pioneering-researcher, David Sinclair on The Charlie Rose Show. Its all here for you too see and examine for yourself, without any hype from us. There are also many links to prominent news stories in the most respected news outlets and organizations, such as the NIH (National Institute of Health). You will find many links to important resveratrol articles from leading publications and leading resources listed here, all in one place for your convenience.

This is all very exciting and impressive but once you have decided whether or not to use supplements containing this substance, there is still the problem of choosing the right supplement.

Avoid supplement products which are made from low-purity trans-resveratrol, because they contain unacceptably high amounts of Emodin. Emodin can act as a laxative and cause stomach cramps and intestinal distress. Read more about it on this website.

Avoid products that contain additional ingredients such as additives, fillers, or other substances.

Avoid any supplement when the label says it contains a proprietary blend. If there is no ingredient label displayed, you dont want it. If the company wont tell you what is in it, you shouldnt take it.

And please, save yourself a lot of aggravation and be sure to absolutely

Avoid free offers. Please read our detailed warnings on these free offer schemes.

Is this unique compound the anti aging secret to controlling the aging process? Can a person in their 80s move and feel like a person in their 50s? Studies have shown that this molecule has offset the effects of high caloric intake in mice and extended their longevity. Will the same effect take place in humans? Can resveratrol supplements prevent diseases associated with aging? Are anti aging and reduced incidence of disease realistic benefits of this substance? Does it help with weight loss? Watch the videos on this website with noted scientists and science writers and hear the facts from them about where the research stands now.

In Vino Sanitus in wine there is health

There was a report some years ago on the TV program 60 Minutes about a study that examined what is known as the French Paradox Study. The French Paradox Study demonstrated that the folks in France were less likely to die from heart disease even though they consumed high fat diets. It was noted in the study that the French consumed large amounts of red wine and the theory developed that the red wine somehow protected the hearts of the wine drinking French people.

Numerous other studies followed and the substance attracted much scientific interest as the possible compound in red wine that may be an important factor in the positive heart healthy effects.

REFERENCES

Wikipediahttps://en.wikipedia.org/wiki/Resveratrol Clinical Trialshttps://clinicaltrials.gov/search/intervention=RESVERATROLNew York Times Topicshttps://www.nytimes.com/topic/subject/resveratrol

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Resveratrol | Which Works Best | Facts About Side Effects

Found in red wine, red or purple grapes, some berries,and dark chocolate, resveratrol is a naturally-occurring polyphenol compound that has been touted as a potential remedy for a range of age-related conditions, including heart disease, diabetes, cancer, and Alzheimer's disease.

Said to contribute to the "French paradox"the observation that people living in France tend to eat a lot of cheese, butter, and other fatty foodsyet have a low incidence of heart diseaseresveratrol consumption has been found to mimic a calorie-restricted diet (which studies have shown can play a role in longevity) and decrease chronic inflammation in the body.

Much of the research pointing to the benefits have been laboratory or animal-based studies. So far, research on resveratrol's effectiveness in humans has yielded mixed results. Here's a look at some key study findings:

1) HeartHealth

For a review published in Clinical Nutrition in 2015, researchers analyzed six previously published studies on the effects of resveratrol on blood pressure, and concluded that resveratrol didn'tsignificantly reduce blood pressure. Higher doses of resveratrol (over 150 mg per day), however, werefound to significantly decrease systolic blood pressure (the top number on a blood pressure reading).

Another review, published in the International Journal of Cardiology in 2015, examined the effectiveness of resveratrol on cardiovascular risk factors. After analyzing 10 previously published studies, researchers concluded that the analysis did not suggest any benefit of resveratrol supplementation on heart disease risk factors, including levels oftotal cholesterol, LDL cholesterol, triglycerides, blood pressure, and C-reactive protein (a blood protein that is raised when there is inflammation, including in heart disease).

2) Aging

There's some evidence that resveratrol may not prolong life, according to research on people living in Tuscany who consume a diet rich in resveratrol from food sources like red wine. In astudy published in JAMA Internal Medicine in 2014, 783 men and women 65 years or older were followed from 1998 to 2009.

During that time, intake of red wine (as measured by urine levels of resveratrol metabolites), didn't change the likelihood of dying from any cause, the incidence of heart disease or cancer, or markers of inflammation.

3) Cancer

A number of preliminary studies suggest that resveratrol may have anti-cancer effects. In a2016 animalstudy, for instance, resveratrol suppressed ovarian tumor regrowth after chemotherapy. Published in Cancer, the study found that resveratrol inhibited the uptake of glucose by cancer cells (many cancer cells depend on glucose as their energy supply).

Despite these findings, the data from the limited human clinical trials have shown inconsistent outcomes and the American Cancer Society cautions that randomized clinical trials are needed to confirm the cancer-fighting effects of resveratrol. (There is also some concern that resveratrol may influence levels of estrogen and other hormones.)

Trans-resveratrol is a form of resveratrol commonly found in supplements. Proponents often claim that trans-resveratrol is the most stable form of resveratrol.

In addition to food sources, resveratrol is also found in Japanese knotweed (Polypodium cuspidatum), grape seed extract, cissus quadrangularis, and white mulberry (Morus alba).

Pterostilbeneis a compound related to resveratrol.

LIttle is known about the safety of long-term or high dose use of resveratrol.

Since resveratrol may possess estrogen-like properties, some medical experts recommend that people with hormone-sensitive cancers (including cancers of the breast, ovary, or uterus), pregnant women, and children avoid taking resveratrol.

In addition, resveratrol could interact with blood thinners like warfarin, aspirin, and ibuprofen, which may raise your risk of bleeding.

According to one study, high-dose resveratrol supplementation was associated with fever,reduced blood cells, and decreased blood pressure.

There is some concern that high doses ofresveratrol supplements could lead to kidney problems in some people.

Supplements haven't been tested for safety and due to the fact that dietary supplements are largely unregulated, the content of some products may differ from what is specified on the product label. You can get tips on usingsupplementshere.

Since the compound was first described in 1992, resveratrol has been studied for its much-touted benefits on the brain, heart, and lifespan, but recent research casts doubt on the notion that resveratrol supplementscan help you live longer or lower your risk of heart disease or cancer.

If you're wondering whether a daily glass of red wine or piece of dark chocolate will improve your health, some researchers note that consumption of red wine, dark chocolate, and some berries has been found to decrease inflammation and have heart-healthy benefits, and suggest that other compounds in these foods may contribute to these benefits.

It's impossible, however, to get anywhere near the doses used in studies from food sources. Many of the studies have used a dose of about 100 mg or more of resveratrol, while a 5-ounce glass of red wine only has about 1 mg of resveratrol.

It's important to note that increasing your intake of red wine comes with a trade-off.Consuming too much may raise your risk of high bloodpressure, liver damage, obesity, and some forms of cancer.

To boost your intake without consuming alcohol, try eating foods like grapes, raspberries, plums,blueberries, cranberries, grape tomatoes, and pomegranate (all of which are rich in resveratrol and a range of antioxidants and nutrients).

If you're still considering using resveratrol supplements, talk to your healthcare provider before starting your supplement regimen to weigh the pros and cons and discuss whether it's appropriate for you.

Sources:

Liu Y, Ma W, Zhang P, He S, Huang D.Effect of resveratrol on blood pressure: a meta-analysis of randomized controlled trials.Clin Nutr. 2015 Feb;34(1):27-34.

Sahebkar A, Serban C, Ursoniu S, et al.Lack of efficacy of resveratrol on C-reactive protein and selected cardiovascular risk factors--Results from a systematic review and meta-analysis of randomized controlled trials.Int J Cardiol. 2015;189:47-55.

Semba RD, Ferrucci L, Bartali B, et al.Resveratrol levels and all-cause mortality in older community-dwelling adults.JAMA Intern Med. 2014 Jul;174(7):1077-84.

Tan L, Wang W, He G, et al.Resveratrol inhibits ovarian tumor growth in an in vivo mouse model.Cancer. 2016 Mar 1;122(5):722-9.

Disclaimer: The information contained on this site is intended for educational purposes only and is not a substitute for advice, diagnosis or treatment by a licensed physician. It is not meant to cover all possible precautions, drug interactions, circumstances or adverse effects. You should seek prompt medical care for any health issues and consult your doctor before using alternative medicine or making a change to your regimen.

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Resveratrol: Benefits and Uses - Verywell

What is Resveratrol?

Resveratrol may be the most significant discovery in supplement history. Resveratrol (pronounced rez-vair-ah-trol) is best known as a red wine molecule, a matchless and distinctive molecule for human health and longevity. Dr. Sinclair in the famous Harvard study discovered the resveratrol molecule stimulates the SIRT1 gene known as the calorie restriction gene, which is the only gene expression proven to extend human life. In the past ten years, hundreds of studies have been conducted with Resveratrol. It provides a healthy response to so many health concerns including cardiovascular disease, weight loss, cancer, diabetes, cognitive decline, etc. scientist say its antioxidant benefits alone are miraculous.

Find out more about Resveratrol

Some things come naturally. The finest wines in all of history come from the Rhone Valley in France, and Vintage Resveratrol 100% is derived naturally from the same grapes. Resveratrol when taken orally is well-absorbed by humans, but its bio-availability is relatively low because our bodies rapidly metabolize and eliminate it; however, French Red Wine Grape Extract from the Rhone Valley provides all the active ingredients that humans can utilize including Trans-Resveratrol, Anthocyanins, & Oligomeric Proanthocyanidins (OPCs). The red grape itself from Rhone Valley provides us the biological blueprint for the most efficient & bio-available source of naturally occurring resveratrol available.

Many supplement companies are getting Resveratrol from an inexpensive Asian herbal source, Japanese Knotweed (Polygonum Cuspidatum). The Natures Trade Group issued a statement concerning the safety of long term use of this herb. Resveratrol using French Red Wine Grape Extract, since 2004, has had extensive testing and research. It is processed using the cleanest processing methods, yielding a pure and potent source of naturally occurring Resveatrol. Vintage Resveratrol 100% has been the top selling supplement at Natural Biology since 2008 - because it works...

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