Category Archives: Resveratrol

Longevinex is more than plain resveratrol

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To learn more about resveratrol and longevity go to ResveratrolNews.com

We also added nutrients that synergize resveratrols anti-aging capabilities of Longevinex

Longevinex cites its own proprietary studies in both animals and humans to substantiate its claims

Longevinex only resveratrol-based nutraceutical to pass toxicity testing.

Journal: Food Chemistry Toxicology Sept 2013, Sept 2013

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Longevinex molecularly mimics a calorie-restricted diet; activates 9-times more longevity genes than plain resveratrol.

Journal: Experimental Gerontology, Sept 2008

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Longevinex dilates (widens) arteries and improves blood flow upon physical exertion twice that of plain resveratrol.

Journal: Nutrition Research, Nov 2011

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Longevinex protects the rodent heart from experimentally-induced heart attack better than plain resveratrol.

Journal: Experimental Clinical Cardiology, Winter 2010

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Promotes health and longevity

Opaque vege caps to protect from light

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100 mg (produces 9-fold greater biological effect than equal dose of plain resveratrol due to synergistic action with other molecules

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Promotes health and longevity

+ youthful appearance

Opaque vege caps to protect from light

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100 mg (produces 9-fold greater biological effect than equal dose of plain resveratrol due to synergistic action with other molecules

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Features, benefits, detailed description

Resveratrol based synergy blend

Resveratrol based synergy blend developed especially to promote youthful appearance

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Resveratrol supplement, dosage and health benefits

Resveratrol acts as an antioxidant and inhibits oxidation of low density lipoproteins (LDL)(21), plateletaggregation, and eicosanoid synthesis(4). It also induces nitric oxide (NO) production(24)(25) and increases arterial blood flow(8). These actions may contribute to its purported cardiovascular health benefits.

Resveratrol acts as an anti-inflammatory agent by inhibiting cyclooxygenase (COX) activity(26). It has been shown to decrease C-reactive protein and tumor necrosis factor, and to increase anti-inflammatory interleukin-10 and intercellular adhesion molecule-1 in humans(5). Resveratrol decreases oxidative stress and improves insulin sensitivity by increasing protein kinase activities(10). It decreases circulating insulin-like growth factor-1 (IGF-I) and IGF-binding protein-3 (IGFBP-3) levels(27) which may account for its antidiabetic effects in humans.

Preliminary data suggest that resveratrol increases the life span of yeast cells by activating sirtuins(1)(2). Recent study shows it inhibits human Sirt3 and stimulates Sirt5, in addition to Sirt1(28).

In vitro and animal studies show that resveratrol has anticancer activities. It inhibits proliferation of cancer cells via apoptosis and by exerting anti-estrogenic effects(14)(15)(16)(17). However, contradictory data from other studies showed that it acts as a phytoestrogen and could activate genes that are normally regulated by estrogens(18) or androgens(19).

Trans-resveratrol appears to decrease methylation of the tumor suppressor gene RASSF-1alpha in women at increased breast cancer risk(29). In addition, reductions in breast cancer cell migration and invasion were observed after treatment with resveratrol(30)(31). Resveratrol growth factor heregulin-beta1 (HRG-beta1) mediated matrix metallopeptidase 9 (MMP-9) expressions in human breast cancer cells(30).

Resveratrol may help reduce prostate tumorigenesis through a reduction inprostatic levels of mTOR complex 1 (mTORC1) activity and increased expression of SIRT1(32). Another study demonstrated that resveratrol modulates steroid hormone-dependent pathways to inhibit prostate cancer cell growth. However, resveratrol also increases angiogenesis and inhibitsapoptosis in vivo(19).

In an animal model, resveratrol downregulated p21and upregulated cyclin E leading to S-phase accumulation and apoptosis in neuroblastoma cells(14). Italso inhibitedCYP1A1, CYP1A2, and CYP1B1 enzymesin tumor cells, perhapsexerting antitumor effects as some of these enzymes are known to be involved in the activation of procarcinogens and toxins(22)(23).

Protective effects of resveratrol against doxorubicin-induced cardiotoxicity are due to upregulation of SIRT1-mediated p53 deacetylation.(20). It also protects against cisplatin-induced cardiotoxicity through the suppression of oxidative stress(19).

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Resveratrol | Memorial Sloan Kettering Cancer Center

Big Pharma is drooling over the prospect of getting it all to themselves.

Resveratrol, a substance found in the skin of red grapes as well as in pomegranates and Japanese knotweed, has been a popular dietary supplement for many years. It has anti-inflammatory and antiviral properties, possibly the potential to extend life, prevent several different cancers, protect the heart, ameliorate common diabetes symptoms, and control plaque in the brain and otherwise help with Alzheimers disease. And that isnt even a complete list. Its clear why drug companies are excited.

Resveratrol is widely available as a dietary supplementbut may not be for long if we are not vigilant. A new study has thrown the excitement over resveratrol into high gear. Results from ten years of research have just been published by David Sinclair, a Harvard Medical School genetics professor and the studys senior author. The research validated earlier findings that resveratrol may protect against age-related diseases because it turns on the SIRT1 gene that recharges mitochondria.

Sinclairs earlier research was partly discounted by other scientists in 2009 and 2010. They suspected that resveratrol might only seem to activate the SIRT1 gene because studies used a synthetic fluorescent chemical to track the effect. Since these synthetic chemicals are not found in nature, they reasoned, the experiment is not reproducible in humans. In this study, however, Sinclair used naturally occurring amino acids to track the benefits, which affirmed the compounds benefits.

Sinclair is not a disinterested party. He is the founder of Sirtris Pharmaceuticals, which focuses on developing resveratrol drugs, that is drugs that will mimic resveratrols effects with new and thus patentable molecules. Pharmaceutical giant GlaxoSmithKline (GSK) acquired Sirtris in 2008 for $720 million. GSK subsequently abandoned its work on resveratrol-based drug SRT501 because the drug didnt appear to work on cancer patients and worsened kidney damage. Its likely, however, that the new findings will prompt GSK to restart its work on a resveratrol-based drug; resveratrol is already the subject of at least two dozen clinical trials.

Because Resveratrol is also the subject of an investigational new drug (IND) application, GSK could petition FDA to ban natural resveratrol. Yes, that s how warped the law is. Apply for FDA approval for something synthetic, new-to-nature, and thus potentially much more dangerous, and you can then try to ban the natural substance on which your product was based.

This is governed by a provision in the law, as we explained last year. There is an absolute prohibition against banning the natural substance if it is grandfathered (that is, marketed before 1994) or if the FDA has accepted a New Dietary Ingredient (NDI) notification from supplement manufacturers.

Supplement companies have tried to file NDIs for resveratrol, but the FDA has rejected them all, stating that an IND had already been filed, so they wont accept an NDI. Despite resveratrol being a natural component of food and a constant part of the food supply, it may be hard to prove that it was marketed before 1994. This, of course, merely reveals the illogic of the grandfathering process: it was put in place as a means of proving the safety of an ingredient, but instead its being used to protect the pharmaceutical industry.

New drug applications (INDs) are confidential, but we can make an educated guess that Sirtris Pharmaceuticals is one of the companies that filed an IND since they have already started clinical drug trials (an IND is required before clinical drug trials). If they are successful, resveratrol will then be available in an expensive, synthetic drug form, likely requiring a prescription at a very high cost and a disease condition for access. It will be tempting for the drug company to then try to have the FDA ban the natural form of resveratrol. It is our job to prevent that by making it painful for both the company and the FDA.

In this context, lets remember what happened to pyridoxamine, one of the three primary natural forms of vitamin B6. Biostratum, the North Carolina-based manufacturer of a planned pyridoxamine-based drug called Pyridorin, petitioned the FDA for market exclusivity, and FDA kowtowed, effectively prevented any substance containing pyridoxamine from being marketed as a dietary supplement. To date no drug has even appeared, so we have neither natural B vitamin nor drug, an outcome that is all too typical of FDA illogic and misuse of power.A similar petition has been filed regarding P5P, the natural form of B6 that is most bio-available. All other forms of B6 must be converted by the body to this form to be used, and without it we would all die. Is this really something to ban and make into an exclusive, prescription-only drug? (If you have not already done so, please send your message to FDA and Congress to make sure P5P remains available as a supplement.)

If the dietary supplement version of resveratrol becomes threatened, rest assured that ANH-USA will be with you on the front lines, fighting to maintain your access to this amazing nutritional ingredient.

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New Study Touts Big Health Benefits of Resveratrol

Which skin type is it good for? Normal Oily Combination Dry Sensitive

What it is:A resculpting treatment serum to reshape, define, and lift the look of skin for a youthful appearance.

Solutions for:- Fine lines and wrinkles- Loss of firmness and elasticity- Dryness

If you want to know moreThis oil-free, innovative resculpting serum is formulated with Caudalie's new breakthrough patent of stabilized vine resveratrol (for firmness) and micro hyaluronic acids (for volume) to visibly recontour, refirm, and replump aging skin. For the first time, these molecules' synergy is being harnessed to support skin's natural production of hyaluronic acid, so the skin is plumped from within. The formula is further enriched with a peptide composition that works on natural collagen and elastin to lift the look of facial contours and reduce visible effects of aging. The light, hydrating texture blends into the skin without any sticky residue and can be applied under makeup.

What it is formulated WITHOUT:- Parabens- Sulfates- Phthalates

What else you need to know:Resveratrol Lift Firming Serum is winner of a Womens Health 2017 Beauty Award.

Research has unveiled a surprising synergy between a molecule from grapevine called resveratrol, and a complex of micro hyaluronic acids. While each ingredient is effective on its own, the combination is a breakthrough because it helps support the skin's own production of natural hyaluronic acid. Hyaluronic acid is naturally present in the skin and plays an important role in hydration and preservation. A decrease in hyaluronic acid quantity and quality with age leads to dryness and the appearance of wrinkles. Caudalie's new patented complex helps support the skin to make its own natural hylauronic acid. This product is noncomedogenic and tested under dermatological supervision.

Research results:% of satisfaction, 100 people, 7 days: - 80% of testers reported denser skin

% of satisfaction, 100 people, 28 days: - 91% of testers reported firmer skin- 76% of testers reported lifted skin

% of satisfaction, 33 people, 56 days: - 85% of testers reported smoothed wrinkles

Continued here:

Resveratrol Lift Firming Serum - Caudalie | Sephora

Which skin type is it good for? Normal Oily Combination Dry Sensitive

What it is:An innovative, natural eye balm with a breakthrough patent to lift and smooth the areas around the eyes and lips.

Solutions for:- Fine lines and wrinkles- Loss of firmness and elasticity- Dryness

If you want to know moreThis cutting-edge eye balm is powered by a patent combining vine resveratrol with micro hyaluronic acids for an unparalleled age-reversing effect. Formulated with advanced peptides and an anti-puffiness plant complex, this eye balm helps lift the look of eyelids, reduce puffiness and dark circles, and smooth the appearance of wrinkles. The texture is silky and melts into skin without the use of synthetic emulsifiersand it works especially well under makeup.

What it is formulated WITHOUT:- Parabens- Sulfates- Phthalates

What else you need to know:Research has unveiled a surprising synergy between a molecule from grapevine called resveratrol, and a complex of micro hyaluronic acids. While each ingredient is effective on its own, the combination is a breakthrough because it helps support the skin's own production of natural hyaluronic acid. Hyaluronic acid is naturally present in the skin and plays an important role in hydration and preservation. A decrease in hyaluronic acid quantity and quality with age leads to dryness and the appearance of wrinkles. Caudalie's new patented complex helps support the skin to make its own natural hyaluronic acid. This fragrance-free product is opthamologist approved for use around the entire eye area, and suitable for sensitive skin and contact lens wearers.

"This natural eye balm is powered by a patent combining vine resveratrol with hyaluronic acid for an age-reversing effect. Formulated with advanced peptides and an anti-puffiness plant complex, this eye balm helps lift the skin of the eyelids, reduce puffiness and dark circles, and smooth the appearance of wrinkles. The texture is silky and melts into skin without the use of synthetic emulsifiers, and it works especially well under makeup.""Dermatologist Karen Hammerman, MD, of Schweiger Dermatology Group

Research results:In a satisfaction test on 100 people, after 28 days:- 80% of testers reported a reduction in under-eye puffiness

Originally posted here:

Resveratrol Lift Eye Lifting Balm - Caudalie | Sephora

Oh, the giddy abandon that overtakes some headline writers when crowning a story about resveratrol, a chemical found in red wine. Heres a sampling of the latest:

All that for an article published today in the journal Cell suggesting that resveratrol blocks the action of a muscle enzyme called phosphodiesterase 4 in mice. Dont get me wrong: its interesting research, that couldemphasis on couldopen the door someday to new treatments for heart disease, diabetes, memory loss, and other chronic conditions. But it doesnt merit the hype that comes with almost any new research on resveratrol.

Resveratrol is a compound that various plants make to fight off bacteria, fungi, and other microbial attackers, or to withstand drought or lack of nutrients. It has been found in red and purple grapes, blueberries, cranberries, mulberries, lingonberries, peanuts, and pistachios. Resveratrol is also abundant in the roots of Japanese knotweed, a plant that has become a hard-to-eradicate invader in the United States.

In 1992, two Cornell University plant scientists suggested that resveratrol might be responsible for the cardiovascular benefits of red wine. Since then, hundreds of reports have indicated that resveratrol mayemphasis on mayprotect against cancer, cardiovascular disease, vascular dementia, and Alzheimers disease, and extend the life span.

Exactly how resveratrol might do all this is still a mystery. One possibility is that it turns on genes that make sirtuins, ancient proteins found in virtually all species. Activating sirtuins kicks off a response that fights disease and prolongs life. The Cell researchers were trying to figure out just how resveratrol might turn on sirtuin genes.

Virtually all of the positive studies on resveratrol have come from cultures of cells or laboratory experiments with yeast, roundworms, fruit flies, the short-lived turquoise killifish, or mice. The few human studies have looked at specific intermediate markers, such as levels of antioxidants, heart rate variability, blood flow to the brain, and amounts of cancer proteins. None have measured long-term health or survival.

Another big unknown is side effects. Resveratrol acts on many different tissues in the body. It is chemically related to estrogen. In some situations, high doses of resveratrol boost the activity of estrogen, in others they block estrogen. That makes resveratrol supplements iffy for women with cancer of the breast, ovary, uterus, or other estrogen-sensitive tissue, those trying to become pregnant, or those taking an oral contraceptive.

Resveratrol makes platelets in the bloodstream less sticky, and so could increase the risk of bleeding in people who take warfarin (Coumadin), clopidogrel (Plavix), aspirin, ibuprofen, or other nonsteroidal anti-inflammatory drugs.

Another cloud: a company called Sirtris Pharmaceuticals, which was established to develop drugs from resveratrol, pulled the plug on the program in 2010 when a clinical trial showed that one of these drugs might be linked to kidney damage.

If you believe that resveratrol will help you live longer and healthier, get it from food or wine, not by choking down resveratrol pills. Why? Eating red grapes, blueberries, and pistachios, or having a glass of your favorite red wine, are pleasurable ways to take in resveratrol. Plus you get all the other healthful plant products that come with the resveratrol. Getting it via supplement is dull, and you cant always trust what you are getting. If you choose to take a supplement, shop carefully. A review by the independent ConsumerLab found that one brand cost just 15 cents per 100 milligrams of resveratrol, while another cost $2.76 per 100 milligrams.

Its worth keeping an eye on resveratrol research. But its far too soon to be promoting it as a fountain of youth or wonder drug.

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Resveratrolthe hype continues - Harvard Health Blog ...