Category Archives: Resveratrol

The ageing global population is the greatest challenge faced by 21st-century healthcare systems. Even COVID-19 is, in a sense, a disease of ageing. The risk of death from the virus roughly doubles for every nine years of life, a pattern that is almost identical to a host of other illnesses. But why are old people vulnerable to so many different things?

It turns out that a major hallmark of the ageing process in many mammals is inflammation. By that, I dont mean intense local response we typically associate with an infected wound, but a low grade, grinding, inflammatory background noise that grows louder the longer we live. This inflammaging has been shown to contribute to the development of atherosclerosis (the buildup of fat in arteries), diabetes, high blood pressure , frailty, cancer and cognitive decline.

Now a new study published in Nature reveals that microglia a type of white blood cells found in the brain are extremely vulnerable to changes in the levels of a major inflammatory molecule called prostaglandin E2(PGE2). The team found that exposure to this molecule badly affected the ability of microglia and related cells to generate energy and carry out normal cellular processes.

Fortunately, the researchers found that these effects occurred only because of PGE2s interaction with one specific receptor on the microglia. By disrupting it they were able normalise cellular energy production and reduce brain inflammation. The result was improved cognition in aged mice. This offers hope that the cognitive impairment associated with growing older is a transient state we can potentially fix, rather than the inevitable consequence of ageing of the brain.

Levels of PGE2 increase as mammals age for a variety of reasons one of which is probably the increasing number of cells in different tissues entering a state termed cellular senescence. This means they become dysfunctional and can cause damage to tissue by releasing PGE2 and other inflammatory molecules.

But the researchers also found that macrophages another type of white blood cells related to microglia from people over the age of 65 made significantly more PGE2 than those from young people. Intriguingly, exposing these white blood cells to PGE2 suppressed the ability of their mitochondria the nearest thing a cell has to batteries to function. This meant that the entire pattern of energy generation and cellular behaviour was disrupted.

Although PGE2 exerts its effects on cells through a range of receptors, the team were able to narrow down the effect to interaction with just one type (the EP2 receptor on the macrophages). They showed this by treating white blood cells, grown in the lab, with drugs that either turned this receptor on or off. When the receptor was turned on, cells acted as if they had been exposed to PGE2. But when they were treated with the drugs that turned it off, they recovered. Thats all fine, but it was done in a petri dish. What would happen in an intact body?

The researchers then carried out one of the cleanest experiments it is possible to perform in biology and one of the best reasons for working on mice. They took genetically modified animals in which the EP2 receptor had been removed and allowed them to grow old. They then tested their learning and memory by looking at their ability to navigate mazes (something of a cliche for researchers) and their behaviour in an object location test. This test is a bit like someone secretly entering your house, swapping your ornaments around on the mantelpiece and then sneaking out again. The better the memory, the longer the subject will spend looking suspiciously at the new arrangement, wondering why it has changed.

It turned out that the old genetically modified mice learned and remembered just as well as their young counterparts. These effects could be duplicated in normal old mice by giving them one of the drugs that could turn the EP2 receptor off for one month. So it seems possible that inhibiting the interaction of PGE2 with this particular receptor may represent a new approach to treating late-life cognitive disorders.

There is a long way to go before we are in a position to start using these compounds in humans even though the prostaglandin systems are very similar. But this study has shed light on a fascinating set of observations linking diet and cognition.

It has been known for some years that eating blueberries and other fruit and vegetables, such as strawberries and spinach, improves cognition in rodents and older people. These foods are rich in molecules such as resveratrol, fisetin and in quercetin, which have been shown either to kill or rescue senescent cells.

There is also evidence that they block PGE2 at the cellular level, providing another route by which these compounds may exert their beneficial effects. Until something better comes along, this is one more piece of evidence that a bowl of fruit wont do you any harm. Though its probably wise to go easy on the cream.

Excerpt from:
Cognitive decline due to ageing can be reversed in mice here's what the new study means for humans - The Conversation UK

Lawmakers and regulators across the globe are not back down from their focus on competition in the marketplace. While big tech has firmly taken center stage, other efforts have been underway, as well, from the Federal Trade Commissions move to block mergers between buzzy direct-to-consumer brands and consumer goods conglomerates in the U.S. to national governments in Europe and the European Commission, alike, exhibiting increased scrutiny when it comes to anti-competitive restraints in agreements between companies and their authorized and unauthorized distributors.

In that same vein, French skincare brand Caudalie is at the heart of a probe by the Belgian Competition Authority (BCA) after the regulator received a complaint from a Belgian store owner that his Caudalie supplier was imposing a strict pricing policy on his subsequent and authorized sale of the companys products. Fast forward to November 20, 2020, and the Belgian competition prosecutor submitted a proposal for a decision in the matter.

According to the proposal, the prosecutor asserted that the minimum resale price requirement that Caudalie has imposed upon the distributor within its selective distribution network, and the Paris-based brands limitation of online sales by its distributors to consumers established in another EU member state run afoul of Article IV.1 of the Code of Economic Law, and Article 101 of the Treaty on the Functioning of the European Union (TFEU), the latter of which bars agreements that aim to restrict, prevent or distort competition within the EU and [that] have an effect on trade between EU member states.

In accordance with the competition law rules as set out in the EU Vertical Agreements Block Exemption Regulation (VBER) and the corresponding the Guidelines on Vertical Restraints, ALTIUS attorneys Carmen Verdonck and Nina Methens state that distributors must always be allowed to freely determine their sales prices, and any agreements between a supplier and its distributor, which directly or indirectly establish a fixed or minimum price or price level to be observed by the distributor when reselling a product to its customers (such as a maximum discount level) are strictly forbidden, as they artificially encourage higher pricing.

Moreover, VBER and the Guidelines also require that companies that maintain a selective distribution system may not prevent distributors operating at the retail level from engaging in active and passive sales towards end users. In other words, Verdonckand Methen assert that distributors must be free to sell, both actively and passively, to all end users, including online. Should a company run afoul of any of these rules, it is considered to be a hardcore vertical restriction that does not benefit from VBERs safe harbor. (VBER establishes the conditions in which a vertical agreement may be considered an exemption under Article 101(3) of the TFEU). Therefore, such an agreement will likely be considered to run afoul ofcompetition law, and be invalid.

For Caudalie specifically, theprosecutors proposed decision will now go before the BCAs Competition College for consideration in furtherance of what Verdonckand Methen say may be the start of another long legal battle for Caudalie. After all, This is not the first time that Caudalie has had to defend itself in competition law cases, they note, pointing to its relatively recently-resolved 5-year-long legal battle with eNova, the operator of online platform 1001pharmacies.com.

In that case, Caudalie filed suit against eNova in April 2013 after it discovered that its products from its Beauty Elixir serum and Vinoperfect Brightening Solution to its Resveratrol-Lift Cream and Instant Detox Mask were being sold on the companys online marketplace site. Responding to Caudalies complaint, eNova argued that Caudalies selective distribution agreements, which explicitly provided that its products could only be sold online by its authorized distributors on their own websites (and thus, not on third-party platforms, such as eNova or Amazon), violated EU competition law, which prohibits such sweeping bans unless they can be objectively justified.

In July 2018, following a decision from the French Supreme Court, the case went back before the Paris Court of Appeal for s second time. This time around, the appeals court held that the marketplace ban in Caudalies selective distribution agreements was, in fact, valid. Guided by the Court of Justice for the European Unions December 2017 decision in the Coty v. Parfmerie Akzente case, in which the court determined that luxury brands may restrict the sale of their goods on third-party online platforms by way of selective distribution systems in order to preserve the quality of their products, the court sided with Caudalie.

Just as in the Coty case, the Paris Court of Appeal determined that Caudalies marketplace ban was necessary in order to preserve the luxury image of it products. Given the absence of any contractual relationship that would oblige 1001pharmacies.com and eNova to comply with Caudalies quality requirements, and given the fact that 1001pharmacies.com was displaying Caudalies products in close proximity to products that had no connection with the cosmetic sector (e.g., fire alarms and video surveillance cameras), the court held that such ban was necessary and proportionate to preserve the products luxury image, Reed Smith stated in a client note at the time.

While eNova attempted to argue that Caudalies application of selection criteria was discriminatory as Caudalie had not initiated proceedings against other platforms, the court was unpersuaded, as Caudalie was able to show that it had initiated proceedings against Amazon on the same basis, as well. As such, the Paris Court of Appeal confirmed the lower courts decision, and ordered that eNova immediately and permanently refrain from offering Caudalie products on its site.

The timing of the newly-initiated Caudalie proceedings in Belgium is striking, as the European Commissionis currently in the midst of assessing the rules contained in VBER and the corresponding Guidelines on Vertical Restraints, which are slated to lapse in 2022. The rules that currently apply to resale price maintenance and active and passive sales are on the commissions radar, according toVerdonckand Methen, who note thattheir concrete application may consequently be adapted or further elaborated on in the commissions ongoing assessment process, which could come as a welcome development for luxury brands that are increasingly seeking to limit how and where their products are sold.

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Caudalie is at the Center of (Another) Anti-Competition Probe Over Resale Price Fixing - The Fashion Law

The worldwide market report of Resveratrol comprised by Regal Intelligence is based on the year 2020. This Industry Report covers manufacturers (international and domestic), suppliers and vendors, regions, product type, product variants, and application for the forecast period.

The analysis provides data over a long period of time, market trends and improvements, factors, obstacles, advances, and changes in the capital structure of the Resveratrol Market. The study will enable market participants and experts to understand the existing market structure.

The Resveratrol Industry report provides a critical overview of activities, including definition, applications, and characterization. The report then examines in detail the major players in the industry at the local and global level. The diagram presented in this report also presents the profile of the organization, details of the items, capacity, and production value, and market shares of each organization.

Leading players of the industry: DSMEvolvaInterHealthMayproLaurus LabsJF-NATURALGreat Forest BiomedicalShaanxi Ciyuan BiotechChengdu YazhongSabinsaChangsha Huir Biological-techXi'an Gaoyuan Bio-ChemXi'an Sinuote

Segmentation of the Resveratrol Market:

According to the type: SyntheticPlant ExtractFermentation

According to End Users:Dietary SupplementCosmeticFood and Beverage

Request your Sample PDF Report: https://www.regalintelligence.com/request-sample/193598

The key market areas that have some degree of development and countless Resveratrol market opportunities have been fully focused on in this report. The current research study focuses on the overall use of primary and secondary data sources. However, the research procedure comprises the analysis of dynamic variables affecting the enterprise, such as administrative policy, the market environment, the competitive landscape, chronic information, current market trends, technological advances, new technologies, and industry-specific advances.

The objective of the report:

The report provides data of the market segmentation by type, application, and domain. The report sets out advancement arrangements and plans, government guidelines, manufacturing processes as well as cost structures. It also covers specialized information, the analysis of the manufacturing plant and the study of the raw material sources of the Resveratrol, as well as details which element has the most notable penetration, their net revenues and the status of R&D. The Resveratrol market analysis also includes a competitive landscape of Resveratrol market, market advancement history, and significant improvement patterns.

Table of Content (TOC) at a glance:

Chapter 1: Overview of the market includes Definition, Specifications, and Classification of Resveratrol market, Features/Characteristics, Scope, and Applications.

Chapter 2: Analysis of Product Cost and Prices: Structure of Manufacturing Cost, Cost of Raw Material and Suppliers, Manufacturing Process, Structure of the Industry Chain.

Chapter 3: Market Supply and Demand Analysis which includes, Capacity and Commercial Production Date, Manufacturing Plants Distribution, State of R&D and Source of Technology, Raw Materials Sources Analysis.

Chapter 4: Forces that keep the marketplace going

Chapter 5 and 6: Regional Market Analysis which includes North America, Europe, China, Japan, Southeast Asia, and India, Resveratrol Market Analysis (by Type).

Chapter 7 and 8: Industrial anatomy

Chapter 9: Analysis of Market Trend, Regional Market Trend, Market Trend according to Product Type.

Chapter 10: Resveratrol sales channel, distributors, retailers, dealers, Research Findings and Conclusion, appendix and data source.

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Ultimately, the report covers the information examined and evaluated accurately on global market participants and their market reach using a variety of logical tools. Analytical instruments, for example, speculation on return on investment review, SWOT study, and study of possible factors are used to analyze the development of the leading global market player in industry Resveratrol.

Thank You.

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Resveratrol Market 2020 Global Industry Extensive Competitive Landscape On Size, Volume, Trends, Share And Revenue| Regional Forecast By 2025 - The...

JUPITER, Fla., Jan. 11, 2021 /PRNewswire/ --Jupiter Orphan Therapeutics, Inc. ("JOT") a biotechnology company pioneering a novel and disease modifying product named JOTROL, today announced that the first patient has been dosed in a Phase I dose escalation study of JOTROL. The Phase I is conducted with healthy volunteers in various ages and include a food effect arm. Per protocol, the first patient cohort has been dosed and the study is continuing in January and February of 2021. Top line data is expected to be available in March 2021. The initial dose appear well-tolerated as the escalation continues toward clinically relevant doses. JOTROL is, through its unique bioavailability, the first and only resveratrol product that can deliver a therapeutically effective dose without causing any severe gastro-intestinal side effects. JOTROL is a platform product that is expected to be an effective treatment in many rare diseases such as ataxias, lysosomal storage disorders and mitochondrial diseases. Building on the positive scientific review and funding from NIA JOT is also in preparation of a Phase II trial for treatment of Mild Cognitive Impairment (MCI).

"We have been able to move the Phase I trial forward very quickly after we received funding from the NIA, $1.76 M, and equity investors, $1.2 M, by setting up clinical material manufacturing through Catalent Pharma Solutions and contracting with Syneos Health Phase I unit in Miami, Florida. We are assuming positive Phase I results, which will be a Proof Of Concept of our product and have started preparations for Phase II trials in MPS-1, Friedreich's ataxia and MELAS in addition to MCI study preparation. We have presently cash covering us through 2021 and are targeting additional financing through an equity raise, possible partnering as well as utilizing non-dilutive funding sources to be able to start several Phase II trials later in 2021," stated Christer Rosn, Chairman and CEO.

"I am very pleased with our progress and excited to be designing efficacy trials in several diseases. Key benefits of a platform product like JOTROL is that the Phase I trial results can be cross-referenced for any Phase II trials involving JOTROL contributing to a very fast and cost-effective way of achieving Phase II study results. There are already human trials executed with nutritional grade resveratrol in several diseases that have shown benefits, although with GI tolerability issues, that gives us confidence for successful outcomes in multiple diseases. With financing in place, we may have positive clinical results already by mid 2022," stated Marshall Hayward, CSO.

For more information about Jupiter Orphan Therapeutics and JOTROLTM, visit http://www.jupiterorphan.com.

Companycontact:

Christer Rosn, Chairman andCEO

[emailprotected]

+1 561 308-7780

Jupiter Orphan Therapeutics, Inc. |601 Heritage Drive |Jupiter, FL 33458

SOURCE Jupiter Orphan Therapeutics, Inc.

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Jupiter Orphan Therapeutics Announces First Patient Dosed in Phase I Dose Escalation Study of JOTROL - PRNewswire

If Im working with a patient or client who incorporates snacks into their daily fueling routine, one of the most frequent go-to snack choices I hear are peanuts or another member of the nut family, such as almonds or cashews. Strategic snacking between meals is one of the best ways to promote appetite management, improve daily nutrition intake and manage energy levels, which strongly correlate with blood sugar levels. Pairing certain foods and nutrients can help stabilize blood sugar, leading to steady energy levels, rather than distracting highs and lows. This is where peanuts come in.

Glycemic index is a value used to quantify the amount that a given food raises blood sugar levels. The values range from 0-100, with lower values indicating less robust blood sugar responses and higher values indicating a significant increase in blood sugar. One serving of a cereal such as corn flakes has a high GI of 81, whereas one serving of soy beans has a GI of approximately 16. Peanuts measure even lower at 14, which means they can help prevent spikes in blood sugar and contribute to a slower and steadier increase in energy. For Type 1 and insulin-dependent Type 2 diabetics, this translates to reduced insulin needs.

Recently, research has shown that the consumption of peanuts and peanut butter can be an effective strategy to stabilize blood sugar and in turn prevent the onset of Type 2 diabetes for those with prediabetes, as well as those with a heightened risk from factors including chronically high blood sugar values and thus drastic fluctuations in energy levels.

A study published in 2018 in the Journal of the American Medical Association found that women who consumed peanut butter five times a week reduced their risk of developing Type 2 diabetes by 21 percent. Additionally, in 2019, the Journal of American Nutrition published research exploring the effect of peanut butter on blood sugar when added to a meal with a high glycemic load. Results showed that the subsequent blood sugar response was significantly lower than when peanut butter was not included in the meal.

The magic lies in the nutrient composition of a peanut, which is low in carbohydrate and high in unsaturated fat. One handful of peanuts also delivers 7 grams of plant-based protein in conjunction with fiber. Thats more plant-based protein than any other nut, with more protein per serving than half a cup of chickpeas. When eating a meal or snack high in carbohydrate or with a high ability to raise your blood sugar, simultaneously consuming foods rich in protein or unsaturated fat adds balance to your blood sugar. Peanuts are an excellent choice, and for this reason some scientists call peanuts a superfood. In addition to protein and healthful fats, peanuts contain 19 micronutrients, including niacin, vitamin E and manganese, which function as antioxidants and contribute to overall health.

Speaking of antioxidants, they can improve vascular function and biomarkers such as blood lipids and cholesterol. Peanuts are a significant source of resveratrol, a nutrient that has recently received increased attention because of its antioxidant capacity. Resveratrol, which is found in grapes and red wine, can open blood vessels and improve blood flow. Peanut butter is very close to grape juice in terms of resveratrol content. If youre trying to up your antioxidant intake, opt for peanut butter, which has three times the reservatrol as roasted peanuts. A study examining bloodwork in response to an evening snack demonstrated that consuming 1 serving of peanuts before bed can reduce blood triglyceride levels. No wonder the World Health Organization and U.S. Department of Agriculture both recommend eating nuts daily.

Despite strong data to support the inclusion of peanuts and/or peanut butter as part of our daily nutrition intake, many shy away from nuts because of the perception that theyre fattening. Almost every day, a patient will tell me they eat peanuts for a snack, and then follow up with I know thats bad! or cringe with guilt. Though peanuts are high in fat, the type of fat found in nuts is the more healthful, protective, unsaturated kind that provides wonderful health benefits. Consumption in moderate amounts has been shown to have no effect on body weight and might even help the body burn more energy.

Other forms of nuts and nut butters provide generally similar nutrition benefits, with a few minute nuances. Peanuts and peanut butter can be a cost-friendly addition to your daily fueling routine. Peanuts can improve blood sugar management, energy levels, cardiovascular markers, stimulate satiety and help regulate appetite. Instead of avoiding this nutrient-dense food, pack on the peanuts!

Emma Willingham is a registered dietitian who practices in an outpatient hospital clinic and through her private practice, Fuel with Emma. Willingham specializes in sports-performance nutrition, weight management and nutrition counseling, and aims to promote a resilient relationship between food, mind and body. You can find her on social media at @fuelwithemma.

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Worried about your blood sugar and diabetes? Add peanuts to your daily diet. - Houston Chronicle

Grapes are berries and the earliest domesticated fruit crop, which is cultivated for use as a fruit, in juices, jams, jellies, pies, and wines.

They are green, red or blue-black. Some grapes are seedless, while others have seeds, some of which are edible.

Although grapes are not locally grown, they are imported and one can access them in some local supermarkets such as Simba Supermarket in town, New Frulep next to Rwandex.

The benefits

Studies show that only one cup of grapes provides about a quarter of ones daily vitamin C needs, nearly 20 per cent for vitamin K, and at least 10 per cent for copper.

In addition to supporting immunity, vitamin C is needed for DNA repair.

Joseph Uwiragiye, the head of the nutrition department at University Teaching Hospital of Kigali (CHUK), says vitamin C also significantly boosts the absorption of iron from plant foods.

He says that a higher blood level of vitamin C is tied to increase fat burning, both during exercise and at rest. Vitamin K is required for bone formation, and a shortfall is linked to increased fracture risk.

The copper in grapes, he says, plays a role in energy production, plus the formation of collagen and red blood cells. Grapes also provide smaller amounts of several key nutrients, including B vitamins, potassium, and manganese.

In addition to the vitamins C and A presence which is vital for immunity, Uwiragiye says grapes support the immune system through their natural anti-microbial properties.

A one-cup portion also supplies about two and a half ounces of water, which is important for hydration, circulation and healthy blood flow, and waste elimination.

Grapes contain lutein and zeaxanthin, which have been known to protect the retina and eye lens.

Theyve been shown to increase visual range, lessen discomfort from glare, enhance visual contrast, and reduce the time it takes the eyes to recover from the strain of bright lights.

Grapes also help lower the risk of macular degeneration and cataracts, two common eye disorders.

For people trying to lose some weight due to certain conditions, or just for fitness, Uwiragiye says consuming grapes can help with weight loss or management.

He explains that this is so because grapes are a low-calorie, fat-free food with a low glycaemic index. These vine-growing goodies also contain compounds with antioxidant properties.

One of them, he says, is resveratrol which is thought to trigger certain reactions that may improve energy metabolism.

Emmy Ntamanga, a Kigali-based consultant, says eating grapes can also help rejuvenate the skin. He explains that this is because grapes are filled with vitamin C and antioxidants which revitalise the skin.

In fact, he says, they can even protect ones skin from cancer-causing ultraviolet radiation and free radicals that can, on a lesser scale, cause wrinkles and dark spots.

Also, the added vitamin C is necessary for the skin to form collagen, which helps give the face a youthful firmness.

For a healthy snack, Uwiragiye says grape is the best option as it helps boosts ones energy.

He explains that the complex carbohydrates found in grapes can give one a much-needed energy boost.

Also, when it comes to cardiovascular health, grapes are overachievers. Some compounds in grapes can help regulate blood pressure, reduce inflammation from oxidative stress, improve blood flow, and protect your vascular system.

Nutritionists say that the manganese found in grapes is a health benefit that helps to strengthen the bones.

Manganese is a mineral already occurring in our bodies in small amounts. It contributes to healthy bones (by allowing your body to better absorb calcium and also creating essential enzymes to build bones).

editor@newtimesrwanda.com

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The goodness of grapes - The New Times