Category Archives: Resveratrol

SUMMARY

They contain calcium pyruvate, a substance that occurs naturally and is made in your body during digestion and metabolism.

A study done by the University of Pittsburgh found out that obese women lost 48% more fat when following a calorie-restricted diet with supplemental calcium pyruvate.

A lot of women around the world undergo the stress of losing belly fat to get that hourglass figure. The following nine nutrients will help you shrink that belly fat.

Cinnamon

Researchers have found out that the active compound Methylhydroxy Chalcone Polymer (MHCP) in cinnamon makes the fat cell more receptive to insulin. High insulin levels trigger the body to store more fat, especially in your midsection, so consuming a seasoning like cinnamon helps maintain healthy levels of insulin, which is a great way to combat belly fat.

Grapes

They contain calcium pyruvate, a substance that occurs naturally and is made in your body during digestion and metabolism. A study done by the University of Pittsburgh found out that obese women lost 48% more fat when following a calorie-restricted diet with supplemental calcium pyruvate.

Caraway seeds

They help to get rid of gas; they are effective at reducing gas and bloating because they are a powerful digestive aid. They help eliminate gas due to their carbamate properties.

Green tea

It has the main components of Polyphenol Epigallocatechin Gallate, which has thermogenic properties to help increase fat oxidation. Green tea is also loaded with powerful antioxidants, which help decrease inflammation and fight off disease and infection.

Omega 3 rich foods

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Studies have shown that they keep stress hormones cortisol and adrenaline from peaking, help the body from chronic stress, and help prevent increased fat storage.

Onions

They contain quercetin, a powerful flavonoid which improves the immune system and promotes cardiovascular health and also fights belly fat.

Dark Chocolate

Studies have indicated that a high level of resveratrol in your diet may boost metabolism, helping you to burn more calories. Its found in red grapes, red wine, and dark chocolate.

Oranges

Vitamin c helps reduce stress hormone levels and returns the stress hormone cortisol to normal levels after a stressful situation. This reduction in cortisol may help to prevent increased belly-fat storage.

Drinking water

Research has shown that an increase in fluid volume in the body may help to promote the breakdown of fat.

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Nine nutrients that will totally shrink your belly - The Standard

Chronic fatigue is an absolutely dreadful condition. Sufferers lack the energy to fully participate in life, and they are often forced to spend their days resting at home after crashing from overdoing physical activity. On bad days you might wake up feeling like youve been hit by a truck and lack the energy to get out of bed. You might be too tired to think or perform at work. There are a number of different loosely-related conditions such as Chronic Fatigue Syndrome (CFS), Myalgic encephalomyelitis (ME), Adrenal Fatigue Syndrome or simply burnout. These conditions were once rare but they are showing up throughout the general population with increasing frequency. The Western medical establishment is rather poor at helping people with chronic fatigue because there is no specific therapy, prescription drug or quick fix that is widely known or agreed upon, says Dr. Bomi Joseph, Director of the Peak Health Center in California. This leaves fatigue sufferers in the catch-22 of being too tired to function well, yet left completely on their own to research & treat themselves. To make matters worse, the modern era subjects us to more stress and stimulation, with less authentic human connection, than at any other era in history.

Low thyroid function, or hypothyroidism, is one of the most common physiological causes of fatigue. If you are also experiencing other low thyroid symptoms like weight gain, depression, anxiety and insomnia, you should ask your doctor to check your blood for low thyroid hormones, low iron, magnesium, Vitamin D or B12, or a MTHFR folate deficiency. But be aware that there is a type of condition called subclinical hypothyroidism where bloodwork shows up normal but the thyroid itself isnt quite functioning properly. Some primary care providers only know the bare basics of nutrition and thyroid, so you may want to visit an endocrinologist specializing in thyroid or an integrated medicine physician.

Graded exercise is an exercise program that is very gradually increased each week. This is important because it strengthens the heart, which pumps blood and oxygen to the tissues, that helps refresh the ATP the body uses up to make energy. Exercise also maintains and builds new muscle tissue, which is filled with mitochondria (cellular energy power plants). People with chronic fatigue may crash if they attempt vigorous exercise and be left sore, exhausted or even bedbound. Depending on how fatigued someone is, they may need to start with as little as 5 minutes of gentle exercise per day and gradually increase the total duration by 5 minutes every week or two. Walking or bicycling is a good place to start. Another great exercise for people with chronic fatigue is yoga as it is moderate in intensity, strengthens ligaments, and it activates the parasympathetic nervous system to reduce stress, says Dr. Joseph. You can start at home with gentle yoga videos on YouTube or Vimeo.

Stimulants like amphetamine or modafinil put oxidative stress on the body and can drive a fatigued person even deeper into energy debt. An exception to that, says UK chronic fatigue specialist Dr. Sarah Myhill, is that one morning cup of black coffee sweetened with 5 grams of a metabolic sugar called d-ribose can help kickstart an exhausted persons energy metabolism. Other superior nutrients for increasing energy are:magnesium, astaxanthin, rhodiola, L-carnitine, ashwagandha & resveratrol.

As a person ages or experiences chronic stress, levels of crucial energy production coenzyme called NAD+ tend to decline, says Dr. Joseph. Thats why the hottest trend in fatigue treatments right now are NAD+ boosters such as nicotinamide riboside, NMN and NAD3. Stacking a combination of resveratrol plus either NAD3 or NMN helps many people feel younger and more energetic with fewer side effects.

A lot of people with chronic fatigue have disturbed sleep patterns. They may stay up late watching television or texting, going to social events or parties, wake up in the middle of the night or take naps during the day. Or they cant fall asleep and have insomnia that throws off their circadian rhythm or internal biological clock. Keeping a circadian rhythm means that you attempt to follow the natural sun-moon cycle our body is intrinsically programmed for. This means being social & active during the day and relaxing and sleeping at night. This is the opposite of social conventions where people like to go out and socialize at night and sleep all morning. You should:

After keeping a circadian rhythm for a few months, many people with chronic fatigue report improvements in their overall energy levels, clarity, and nighttime sleep quality.

Here is a major and somewhat controversial secret: oftentimes chronic fatigue is caused or exacerbated by a buildup of suppressed negative emotions and blocked energy. Neither mainstream medicine or psychiatry understand this phenomena well and so they dont offer good solutions for coping with it. Both anecdotal reports and scientific studies suggest that people with chronic fatigue have more PTSD & less emotional coping strategies than healthy and unfatigued people.

Say you are having a difficult day at work: a customer is very rude to you, there are frustrating technical computer issues and then your boss criticizes your performance on a project. These unpleasant stimuli can cause an emotional flashback where all the unprocessed negative memories & emotions from your past that are stored in your psyche get awakened, start to subconsciously replay in the back of your mind. All kinds of negative and sad memories get subconsciously reactivated. This very often this happens without you even consciously realizing what is going on you just feel stressed, agitated, depressed and more vigilant than usual, says Dr. Bomi Joseph.

Your mind wants to keep you safe, so it works on overdrive to keep these negative, unprocessed experiences and impressions pent up and out of your thoughts. This process uses up an extraordinary amount of emotional energy that, after several hours or days, usually leaves you feeling drained and wiped out. Typically, a chronic fatigue sufferer will think something like Oh no, I am really physically exhausted. I must lie down and rest. I cant go out and visit friends this weekend or else I will be even more exhausted. Then they become caught in a cycle of staying home, laying low, avoiding friends, work and activities because they think the fatigue has a physical rather than emotional origin. They rest frequently and intensively, sometimes for years, and become physically weaker while not improving their energy levels. In reality, when a person feels fatigued and it is not due to heavy physical exercise, it is most likely due to this subconscious cognitive resistance dynamic. If the sufferer stops what they are doing and becomes mindful of everything that they are feeling under the surface and they dive deep into the negative thoughts and physical sensations rather than trying to block them out the draining emotional charge that fuels the fatigue begins to dissipate. Then the fatigue itself begins to dissipate in a matter of hours or minutes. The book The Intelligent Body by Kyle Davie explores this process of psychologically healing fatigue in depth.

With the proper lab tests, exercise, vitamins and sleep you may be able to improve your energy levels significantly. If you have done all of these physical tweaks and you are still feeling exhausted you may want to explore emotional awareness and release techniques or PTSD/trauma therapy. Chronic fatigue is a terrible condition but there is hope: it can also be an amazing self-awareness journey and, in many cases, it can be dramatically improved or even cured.

Read more:
How to Handle Chronic Fatigue According to Dr. Bomi Joseph - Thrive Global

While numerous studies have teased at potential benefits of resveratrol, a polyphenolic compound found in red wine and many plants, scientists are still trying to understand its impact on the human body. In a recent study out of University College London, author Dr. Henry Bayele has found an interesting explanation for its potential as an antiaging substance. Dr. Bayeles team found that resveratrol can mimic the hormone estrogen in the human body to activate antiaging proteins called sirtuins, which may help prevent age-related health problems.

The study, published in Scientific Reports, explores dietary sirtuin-activating compounds (dSTACs), including resveratrol. Sirtuins have become a promising target for researchers interested in slowing the aging process. They are proteins produced by the body that appear to impact metabolism and protect against several conditions including obesity, type 2 diabetes, cancer and cardiovascular and neurodegenerative diseases. Learning what spurs the body to produce sirtuins has been a common goal of longevity-focused scientists over the past two decades.

The interest in sirtuins started in 1999, when it was reported that the proteins activation can extend yeast lifespans by as much as 70 percent. The antiaging action of sirtuins appears to be conserved from yeast to mammals, stated a 2017 study published in Biogerontology. However, the complexity of their function increases with the complexity of the organism.

In the lab, Dr. Bayele and his team treated human liver cells in vitro with different types of compounds and found that resveratrol activated sirtuin signals through estrogen receptors by mimicking the hormone. Although estrogen is commonly defined as a female hormone, men and women both produce it, and it can help protect against the same things sirtuins prevent, such as heart disease.

Results also showed that resveratrol mimics estrogen in low doses, but becomes antiestrogenic in higher concentrations, consequently suppressing sirtuin signals. Excessive intake may in fact be counterproductive because, in high doses, the study found that resveratrol inhibited sirtuin activation of the estrogen receptors, Dr. Bayele told Wine Spectator. Therefore, the low doses of resveratrol found in a regular glass of red wine should be sufficient to activate the sirtuins. Simply put, for red wine or resveratrol to improve healthspan, less is more.

So whats a low dose? Dr. Bayele explains that a regular glass of table wine contains about 0.5 to 1 milligram of resveratrol. Of note, these concentrations are similar to those at which resveratrol behaves like estrogen to induce maximal sirtuin signaling through the estrogen receptors, he said.

Other dSTACs studied were better than resveratrol at activating sirtuins, such as isoliquiritigenin, which is found in licorice. According to Dr. Bayele, resveratrol has attracted the most attention due to its accessibility in red wine, combined with its demonstrable protection against metabolic, cardiovascular and neurodegenerative diseases. It has been shown to increase lifespan in diverse organisms, he writes in the study.

While the research shows promise, the findings have yet to face human trials or long-term studies, and must be better understood before potential treatments can be developed. Dr. Bayele also warns that dSTACs are poorly soluble, and its difficult to determine how much are absorbed in the cell culture. His main takeaway is that wine lovers must also incorporate a healthy diet to improve healthy aging and prevent the onset of metabolic and age-related diseases.

In the case of resveratrol, Dr. Bayele says that when humans consume it, only small amounts are rapidly absorbed, while a large proportion gets metabolized in the small intestine, which complicates the validity of the data. In short, it is still unclear how resveratrol intake would affect sirtuin signaling in vivo, but Dr. Bayele is confident that these dietary compounds are hidden treasures.

While [resveratrols] role in aging/lifespan regulation remains controversial, Dr. Bayele writes, Its contribution to healthspan is not in doubt.

Read the original here:
How Might Resveratrol and Red Wine's Antiaging Properties Work? - Wine Spectator

The Australian team also concludes that resveratrol consumption amongst postmenopausal women can also contribute to enhanced cognitive and cerebrovascular functions.

Our observed improvement in overall cognitive performance with resveratrol could potentially reverse cognitive ageing by up to 10 years says Dr Rachel Wong, a dementia research fellow with the National Health and Medical Research Council and the Australian Research Council (NHMRC-ARC).

We observed an improvement in overall cognitive performance which appeared to be due to improvements in processing speed and cognitive flexibility, which are critical to supporting executive function in the aging population.

Since 1990, the number of people globally living with dementia has more than doubled. In 2016, dementia mortality rates in women were almost twice that of men.

This may be partly attributable to the abrupt decline of oestrogen at menopause and the associated loss of its protective effects on cardiovascular and neural functions.

Resveratrol, found in grapes, berries and nuts, has been shown to improve endothelial vasodilator function in humans and improvements to verbal memory in older adults after six months of 200 mg of supplementation per day compared to placebo.

Further research points to doses of 250 milligrams (mg) and 500mg of resveratrol as contributing to increases of resting cerebral blood flow (CBF) in younger adults, although cognitive function was not affected.

Another study found that 75mg resveratrol, the lowest dose tested, was the most efficacious dose to acutely elicit global cerebral vasodilatation and improve performance of a sustained attention task in type 2 diabetes patients.

Along with colleagues from the University of South Australia, Dr Wong began randomising 129 volunteers to consume either two capsules containing 75mg of Evolvas Veri-te resveratrol ingredient daily or a matching placebo supplement for 12 months, followed by the alternate treatment for a further 12 months.

Results of the RESHAW (Resveratrol Supporting Healthy Aging in Women) clinical study found that compared to placebo, resveratrol improved overall cognitive performance, whilst weakening the decline in cerebrovascular responsiveness (CVR) to cognitive stimuli. The latter effect was associated with reduction of fasting blood glucose.

The evidence in this first report confirms our previous observations in both men and women that a regular low dose of resveratrol can sustain cerebrovascular function, which has helped to preserve cognitive function, particularly in the more elderly women, says Peter Howe, emeritus professor at the University of Newcastles Clinical Nutrition Research Centre.

Most importantly, it shows that these benefits are not short-lived but can be sustained with ongoing supplementation for at least 12 months.

The team, which also includes Dr Jay Jay Thaung Zaw, also from Australias University of Newcastle, think the results may be partly overseen by improvements to endothelium-dependent vasodilator function, which modulates CBF during times of demand.

We found improved resting blood flow velocities (BFV), stiffness in the cerebral vessels or pulsatility index (PI) and weakening of decline in neurovascular coupling following resveratrol supplementation, the paper discusses.

Allowing for normal ageing processes, cognitive decline and ultimately, dementia are linked to accelerated decline in resting CBF and CVR due to a decreased delivery of oxygen and nutrients in vulnerable brain regions such as the hippocampus.

Cerebral artery stiffness, marked by increased PI, is also associated with cognitive impairment and predicts the progression from mild cognitive impairment to dementia.

The study concludes that taking this evidence into account, the team think the improvements in resting BFV and PI with resveratrol highlights the ability of regular resveratrol supplementation to sustain cerebrovascular function, which may, in turn, preserve cognitive function in elderly women.

This publication from the team at the University of Newcastle highlights the benefits that Veri-te resveratrol can have on brain health, making resveratrol an essential ingredient for postmenopausal women and healthy aging,

This first peer-reviewed publication from the RESHAW clinical study provides the evidence that supplementation with Veri-te resveratrol should be a key strategy for the design and delivery of effective supplements that may attenuate the decline in brain health as women age and improve overall wellbeing post-menopause, says Clare Panchoo, VP, Health Ingredients, Evolva.

Source: Nutrients

Published online ahead of print: doi.org/10.3390/nu12030828

Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women.

Authors: Jay Jay Thaung Zaw et al.

See original here:
Resveratrol may reverse cognitive ageing by ten years - NutraIngredients.com

Evolva (Reinach, Switzerland) has announced the first published findings1 from the Resveratrol Supporting Healthy Aging in Women (RESHAW) clinical study, conducted by the University of Newcastle in Australia and funded by the countrys National Health and Medical Research Council. This two-year clinical trial is the largest and longest-running trial of its kind, investigating the impact of Evolvas branded Veri-te resveratrol on cognitive performance. Interim results were announced at SupplySide West 2019.

In the double-blind, placebo-controlled crossover design, 125 post-menopausal women were assigned to either receive 75 mg of resveratrol or placebo twice daily for 12 months, then switched interventions for the next 12 months. Results showed performance on Pattern Comparison Speed tests improved in the resveratrol group, compared to placebo, which the researchers believe is due to the significant improvements in two cognitive domains, processing speed and cognitive flexibility. Both of these domains are part of executive function, requiring speed, perceptual reasoning, and accuracy to accomplish tasks. Executive function declines with age, with processing speed and cognitive flexibility being among the first cognitive changes reported in healthy older adults.

The researchers hypothesize that the cognitive improvements may be due, in part, to sustained improvement of endothelium-dependent vasodilator function, which modulates cerebral blood flow during times of demand. Subjects taking resveratrol saw significant improvements in basal blood flow velocities (systolic, mean, and diastolic), and pulsatility index, which is a measure of the stiffness in cerebral vessels, compared to placebo. Neurovascular coupling capacity also saw improvement, especially in response to tests of cognitive flexibility. This is important because cognitive decline and ultimately dementia are linked to accelerated decline in resting cerebral blood flow and cerebrovascular function due to decreased delivery of oxygen and nutrients to vulnerable parts of the brain such as the hippocampus.

This momentous publication from the team at the University of Newcastle highlights the benefits that Veri-te resveratrol can have on brain health, making resveratrol an essential ingredient for postmenopausal women and healthy aging, said Clare Panchoo, vice president, Health Ingredients, Evolva, in a press release. This first peer-reviewed publication from the RESHAW clinical study provides the evidence that supplementation with Veri-te resveratrol should be a key strategy for the design and delivery of effective supplements that may attenuate the decline in brain health as women age and improve overall wellbeing post menopause.

Our customers have been anticipating the results from RESHAW and have already initiated new product development based on this first publication; we further expect the positive outcomes to drive sales of Veri-te resveratrol globally, adds Panchoo.

References:

1. Thaung Zaw JJ et al. Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women. Nutrients, vol. 12, no. 3 (2020): 828

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Resveratrol supports cognitive health in aging populations, says groundbreaking RESHAW study - Nutritional Outlook

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HUNTER researchers suspect a substance found in grapes and nuts could be an effective treatment for women who suffer from debilitating menstrual migraines. University of Newcastle researchers have already established a link between menstrual migraines and blood vessel function in the brain. Now they are recruiting for a world-first clinical trial into whether "resveratrol" - a naturally occurring substance found in the skin of grapes - could alleviate the symptoms and frequency of these migraines. Registered pharmacist and PhD candidate Jemima Dzator said there had been previous studies where the nutritional supplement had been proven to help blood vessel function in the brain. But this trial would be a world-first look at whether it could also have an effect on women who suffer from hormone-related migraines each month. "There is not a lot of study surrounding menstrual migraine to begin with, even though migraines are very, very common, and affect more women than men," Ms Dzator said. "These migraines are very debilitating," Ms Dzator said. "It can put them out of work for days, it can affect the way they interact with their family and friends, their social life, and their emotional well being." They tended to occur at certain points of the menstrual cycle - usually like clockwork, and had been shown to be more recurrent, more painful, longer lasting and more resistant to current treatment compared to regular migraines. Ms Dzator said there was currently no approved treatment for menstrual migraine in Australia. She said one-in-10 women experienced menstrual migraines that were likely due to changes in hormone levels, particularly oestrogen. But if this trial was successful, it could provide a long-awaited treatment option that could reduce the frequency, severity and intensity of menstrual migraines for many sufferers. "Because we found a link between poor or abnormal blood vessel function in the brain in the menstrual migraine group in our previous study, now we want to see it improving their blood vessel function in the brain and, ultimately, reducing their menstrual migraine frequency and improving their quality of life," Ms Dzator said. "We do think that by improving the blood vessel function in the brain that it should be able to help." Ms Dzator said they were looking for approximately 80 women aged between 18 and 50 years old who suffer from migraines related to their period. "If they are eligible, they will be asked to take two supplement capsules daily for six menstrual cycles, and visit our research centre on three occasions where their blood vessel function will be measured via ultrasound," she said. To find out more, call the Clinical Nutrition Research Centre on (02) 4921 8616 or email cnrc@newcastle.edu.au.

https://nnimgt-a.akamaihd.net/transform/v1/crop/frm/U6sg88yptnWPBj3pxEuthQ/06f5fc91-3cea-49e0-a796-224fb4f0f71c.JPG/r0_165_4562_2743_w1200_h678_fmax.jpg

HUNTER researchers suspect a substance found in grapes and nuts could be an effective treatment for women who suffer from debilitating menstrual migraines.

Now they are recruiting for a world-first clinical trial into whether "resveratrol" - a naturally occurring substance found in the skin of grapes - could alleviate the symptoms and frequency of these migraines.

Registered pharmacist and PhD candidate Jemima Dzator said there had been previous studies where the nutritional supplement had been proven to help blood vessel function in the brain.

But this trial would be a world-first look at whether it could also have an effect on women who suffer from hormone-related migraines each month.

"There is not a lot of study surrounding menstrual migraine to begin with, even though migraines are very, very common, and affect more women than men," Ms Dzator said.

"These migraines are very debilitating," Ms Dzator said. "It can put them out of work for days, it can affect the way they interact with their family and friends, their social life, and their emotional well being."

They tended to occur at certain points of the menstrual cycle - usually like clockwork, and had been shown to be more recurrent, more painful, longer lasting and more resistant to current treatment compared to regular migraines.

Ms Dzator said there was currently no approved treatment for menstrual migraine in Australia.

She said one-in-10 women experienced menstrual migraines that were likely due to changes in hormone levels, particularly oestrogen.

But if this trial was successful, it could provide a long-awaited treatment option that could reduce the frequency, severity and intensity of menstrual migraines for many sufferers.

"Because we found a link between poor or abnormal blood vessel function in the brain in the menstrual migraine group in our previous study, now we want to see it improving their blood vessel function in the brain and, ultimately, reducing their menstrual migraine frequency and improving their quality of life," Ms Dzator said.

"We do think that by improving the blood vessel function in the brain that it should be able to help."

Ms Dzator said they were looking for approximately 80 women aged between 18 and 50 years old who suffer from migraines related to their period.

"If they are eligible, they will be asked to take two supplement capsules daily for six menstrual cycles, and visit our research centre on three occasions where their blood vessel function will be measured via ultrasound," she said.

To find out more, call the Clinical Nutrition Research Centre on (02) 4921 8616 or email cnrc@newcastle.edu.au.

Read more from the original source:
University of Newcastle research looks at natural substance resveratrol to see whether it alleviates symptoms and frequency of menstrual migraines -...