Category Archives: Nano Medicine

SALT LAKE CITY, Jan. 21, 2020 /PRNewswire/ --Clene Nanomedicine, Inc., a clinical-stage biopharmaceutical company, today announcedits Australian subsidiary had completed enrollment and dosing of the first participant in the Phase 2 RESCUE-ALS study with its lead nanocatalytic therapy, CNM-Au8, for the treatment of Amyotrophic Lateral Sclerosis (ALS). The RESCUE-ALS study is substantially funded by FightMND.

"The objective of the randomized, double-blind RESCUE-ALS study is to demonstrate that improvements in brain bioenergetic cellular support in early symptomatic ALS patients treated with CNM-Au8 will help preserve motor neurons survival and function. The primary endpoint is the mean change in the average difference between active treatment and placebo from baseline through week 36 for the Motor Unit Number Index (MUNIX) score, which quantitatively reflects the loss of motor neurons in ALSthe primary cause of clinical progression in ALS," said Robert Glanzman, MD, FAAN, Clene's Chief Medical Officer.

"We are excited to advance CNM-Au8 clinically into this Phase 2 study for ALS patients," said Rob Etherington, President and CEO of Clene. "As neurodegenerative diseases such as ALS have very few treatment options, this study will prove whether CNM-Au8 may be an effective disease-modifying treatment for people with ALS."

"We are very excited to partner with Clene on the Phase 2 study in ALS, RESCUE-ALS," said Professor Steve Vucic, Director of Neurophysiology, Department of Neurology, at Sydney Medical School, Westmead Hospital. "CNM-Au8 offers an innovative approach of potentially treating neurodegenerative diseases, such as ALS, for which there are no effective treatments at present. We are hopeful that CNM-Au8 will be an effective therapy in the future and this trial will go a long way in addressing this question."

About RESCUE-ALS

RESCUE-ALS is Phase 2 multi-center randomized, double-blind, parallel group, placebo-controlled study examining the efficacy, safety, pharmacokinetics, and pharmacodynamics of CNM-Au8 in participants who are newly symptomatic ALS (within 24-months of screening or 12-months from diagnosis) and with a clinically probable or possible or definite ALS diagnosis. Enrolled subjects will be randomized 1:1 to receive either active treatment with CNM-Au8 30 mg or placebo in addition to their current standard of care. Participants will receive their randomized oral treatment daily over 36 consecutive weeks during the Treatment Period. The treatment is taken by mouth once daily first thing every morning. The objective of this study is to assess bioenergetic catalysis with CNM-Au8 to slow disease progression in patients with ALS.

About CNM-Au8

CNM-Au8 is a concentrated, aqueous suspension of clean-surfaced faceted nanocrystalline gold (Au) that acts catalytically to support important intracellular biological reactions. CNM-Au8 consists solely of gold atoms organized into faceted, geometrical crystals held in suspension in sodium bicarbonate buffered, pharmaceutical grade water. CNM-Au8 has demonstrated safety in Phase 1 studies in healthy volunteersand both remyelination and neuroprotection effects in multiple preclinical models. Preclinical data presented at scientific congresses demonstrated that treatment with CNM-Au8 in neuronal cultures improved survival of neurons, protected neurite networks, decreased intracellular levels of reactive oxygen species, and improved mitochondrial capacity in response to cellular stress, induced by multiple disease-relevant neurotoxins. Oral treatment with CNM-Au8 improved functional behaviors in a rodent models of ALS, multiple sclerosis, and Parkinson's disease versus vehicle (placebo). CNM-Au8 has received regulatory approval to proceed to clinical studies for the treatment of remyelination failure in patients with multiple sclerosis and neuroprotection in patients with amyotrophic lateral sclerosis(ALS) and Parkinson's disease.

About Amyotrophic Lateral Sclerosis (ALS)

ALS is a universally fatal neurodegenerative disorder that results in loss of motor neurons in the cerebral cortex, brain stem, and spinal cord. ALS, also known as Lou Gehrig's disease, leads to the death of the neurons controlling voluntary muscles resulting in weakness, muscle atrophy, and progressive paralysis. ALS affects more than 15,000 patients in the United States and is the most prevalent adult-onset progressive motor neuron disease.

About Clene

Clene Nanomedicine, Inc. is a privately-held, clinical-stage biopharmaceutical company, focused on the development of unique therapeutics for neurodegenerative diseases. Clene has innovated a novel nanotechnology drug platform for the development of a new class of orally-administered neurotherapeutic drugs. Founded in 2013, the company is based in Salt Lake City, Utah with R&D and manufacturing operations located in North East, Maryland. For more information, please visit http://www.clene.com.

About FightMND

FightMND is a not-for-profit registered charity, founded in 2014. It was established to raise the awareness of Motor Neurone Disease (MND) in Australia, to increase funding for research to find an effective treatment and cure and to provide care equipment for MND patients. We have a clear objective to a have a world free from MND.

FightMND is Australia's largest independent MND foundation focused on funding large- scale, collaborative research and clinical trials. The generous donations contributed by everyday Australians, right across the country, has enabled FightMND to raise and commit millions to cure and care initiatives.

Investor ContactKaitlyn BroscoThe Ruth Group646-536-7032 kbrosco@theruthgroup.com

Media Contact Kirsten ThomasThe Ruth Group508-280-6592 kthomas@theruthgroup.com

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SOURCE Clene Nanomedicine, Inc.

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Clene Nanomedicine Announces First Patient Dosed in the RESCUE-ALS Clinical Trial for the Treatment of Amyotrophic Lateral Sclerosis (ALS) with Lead...

Syed Abdullah Alkaff, 1 Krishna Radhakrishnan, 1 Anu Maashaa Nedumaran, 1 Ping Liao, 2 Bertrand Czarny 1, 3

1School of Materials Science and Engineering, Nanyang Technological University 639798, Singapore; 2Calcium Signalling Laboratory, National Neuroscience Institute 308433, Singapore; 3Lee Kong Chian School of Medicine, Nanyang Technological University 639798, Singapore

Correspondence: Bertrand CzarnySchool of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Ave, Block N4.1, #02-17 639798, SingaporeTel +65 67904613Email bczarny@ntu.edu.sg

Abstract: The technology of drug delivery systems (DDS) has expanded into many applications, such as for treating neurological disorders. Nanoparticle DDS offer a unique strategy for targeted transport and improved outcomes of therapeutics. Stroke is likely to benefit from the emergence of this technology though clinical breakthroughs are yet to manifest. This review explores the recent advances in this field and provides insight on the trends, prospects and challenges of translating this technology to clinical application. Carriers of diverse material compositions are presented, with special focus on the surface properties and emphasis on the similarities and inconsistencies among in vivo experimental paradigms. Research attention is scattered among various nanoparticle DDS and various routes of drug administration, which expresses the lack of consistency among studies. Analysis of current literature reveals lipid- and polymer-based DDS as forerunners of DDS for stroke; however, cell membrane-derived vesicles (CMVs) possess the competitive edge due to their innate biocompatibility and superior efficacy. Conversely, inorganic and carbon-based DDS offer different functionalities as well as varied capacity for loading but suffer mainly from poor safety and general lack of investigation in this area. This review supports the existing literature by systematizing presently available data and accounting for the differences in drugs of choice, carrier types, animal models, intervention strategies and outcome parameters.

Keywords: nanoparticle, drug delivery system, stroke, animal model, nano medicine, therapeutics

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Nanocarriers for Stroke Therapy: Advances and Obstacles in Translating | IJN - Dove Medical Press

Xiaoyi Zhang, 1, 2 Yixin Zhang, 1, 2 Yaonan Wang, 1, 2 Jianhui Wu, 1, 2 Haiyan Chen, 1, 2 Ming Zhao, 13 Shiqi Peng 1, 2

1Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, Peoples Republic of China; 2Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, Peoples Republic of China; 3Beijing Laboratory of Biomedical Materials and Key Laboratory of Biomedical Materials of Natural Macromolecules, Department of Biomaterials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100026, Peoples Republic of China

Correspondence: Shiqi Peng; Ming ZhaoDepartment of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, No. 10, Youanmenwaixitoutiao, Fengtai District, Beijing 100069, Peoples Republic of ChinaTel +86 10 8391 1528; +86 10 8391 1535Fax +86 10 8391 1528; +86 10 8391 1533Email sqpeng@bjmu.edu.cn; maozhao@126.com

Background: 1-(4-isopropylphenyl)--carboline-3-carboxylic acid (ICCA) was modified by Trp-Phe-Phe to form 1-(4-isopropylphenyl)--carboline-3-carbonyl-Trp-Phe-Phe (ICCA-WFF).Purpose: The object of preparing ICCA-WFF was to enhance the in vivo efficacy of ICCA, to explore the possible targeting action, and to visualize the nano-feature.Methods: The advantages of ICCA-WFF over ICCA were demonstrated by a series of in vivo assays, such as anti-tumor assay, anti-arterial thrombosis assay, anti-venous thrombosis assay, P-selectin expression assay, and GPIIb/IIIa expression assay. The nano-features of ICCA-WFF were visualized by TEM, SEM and AFM images. The thrombus targeting and tumor-targeting actions were evidenced by FT-MS spectrum analysis.Results: The minimal effective dose of ICCA-WFF slowing tumor growth and inhibiting thrombosis was 10-fold lower than that of ICCA. ICCA-WFF, but not ICCA, formed nano-particles capable of safe delivery in blood circulation. In vivo ICCA-WFF, but not ICCA, can target thrombus and tumor. In thrombus and tumor, ICCA-WFF released Trp-Phe-Phe and/or ICCA.Conclusion: Modifying ICCA with Trp-Phe-Phe successfully enhanced the anti-tumor activity, improved the anti-thrombotic action, formed nano-particles, targeted tumor tissue and thrombus, and provided an oligopeptide modification strategy for heterocyclic compounds.

Keywords: ICCA, modification, Trp-Phe-Phe, anti-tumor, thrombus targeting, release, toxicity, nano-species

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Modifying ICCA with Trp-Phe-Phe to Enhance in vivo Activity and Form N | IJN - Dove Medical Press

The ability of metallic nanoparticles to harvest and control light is transforming scientific research, according to physicists from the University of Bath.

Writing in Advanced Optical Materials, Prof Valevs team reviews the current state of nanotechnology research and discusses its likely applications in the near and medium future.

Ph.D. student Lukas Ohnoutek sees nanomedicine a branch of medicine that uses nanotechnology to improve the diagnosis and treatment of disease as a particularly buoyant area of research. On-command delivery of drugs has already proven successful in several animal trials, he says. Using this technology, medicines encapsulated in nanomaterials are directed to a specific site in the body before releasing their active ingredients in a highly controlled manner.

It is crucial to increase the efficiency of drugs and to reduce side effects, and this is something that can be achieved with on-command drug delivery, said Mr. Ohnoutek. By illuminating metal nanoparticles, it is possible to control the location, time, and amount of drug released in a patient.

Research fellow Dr. Kristina Rusimova says dramatic improvements are expected in the treatment of cancer, thanks both to on-command drug delivery and photothermal cancer therapy (PTT). PTT involves injecting nanoparticles into a patients body, where they accumulate in the tumor. When the particles are then subjected to radiation, they heat up and destroy the tumor with very little damage to surrounding tissue. In animal trials, advanced tumors have completely disappeared following photothermal therapy.

We have looked at animal trials conducted on mice, cats and dogs, said Dr Rusimova. In each case, the treatment seemed successful, which is very encouraging for treatment in humans. We know that human trials have been approved and are currently ongoing, so we are cautiously optimistic.

Other research is focused on finding nanotechnology solutions to the climate crises. There is hope that non-radiative plasmonic decay will provide a new method for improving solar cells and for producing hydrogen fuel directly from water. This process is known as water splitting. The result will be an efficient and economical low-carbon fuel, particularly suitable for heating homes and other spaces.

Other tantalizing applications for metallic nanoparticles technology include advanced biomedical imaging, improved magnetic storage and nanorobotics, where robots are manufactured with components on the nanoscale.

Prof Valev said: The tiniest metal pieces can now be formed, cut and joined with light. This allows us to integrate humanitys knowledge of metal working with our understanding of molecular self-assembly and nanoscale biotechnology. This research field offers some truly amazing perspectives for the future.

These prospects are all built around the ability of metallic nanoparticles to harvest and control light at the subwavelength scale.

Reference: Hot in Plasmonics: TemperatureRelated Concepts and Applications of Metal Nanostructures by Christian Kuppe, Kristina R. Rusimova, Lukas Ohnoutek, Dimitar Slavov and Ventsislav K. Valev, 26 November 2019, Advanced Optical Materials.DOI: 10.1002/adom.201901166

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Science Revolution Sparked by Rapid Progress in Nanotechnology - SciTechDaily

Global Nanorobotic Market Report 2019 Market Size, Share, Price, Trend and Forecast is a professional and in-depth study on the current state of the global Nanorobotic industry.

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Segment by RegionsNorth AmericaEuropeChinaJapan

Segment by TypeNanomanipulatorBio-NanoroboticMagnetically Guided Robot

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Chapter 3, the Nanorobotic competitive situation, sales, revenue and global market share of top manufacturers are analyzed emphatically by landscape contrast.

Chapter 4, the Nanorobotic breakdown data are shown at the regional level, to show the sales, revenue and growth by regions, from 2019 to 2025.

Chapter 5, 6, 7, 8 and 9, to break the sales data at the country level, with sales, revenue and market share for key countries in the world, from 2019 to 2025.

Chapter 10 and 11, to segment the sales by type and application, with sales market share and growth rate by type, application, from 2019 to 2025.

Chapter 12, Nanorobotic market forecast, by regions, type and application, with sales and revenue, from 2019 to 2025.

Chapter 13, 14 and 15, to describe Nanorobotic sales channel, distributors, customers, research findings and conclusion, appendix and data source.

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Nanorobotic Segments, Opportunity, Growth and Forecast By End-use Industry 2019-2020 Dagoretti News - Dagoretti News

Saturday, 11 January 2020

An international group of scientists has reported on a technique to kill cancer cells in mice using a combination of immunotherapy and nano-particles of copper oxide.

The group is made up of researchers from the universities of Leuven, Bremen in Germany and Ioannina in Greece, as well as the Leibnitz Institute for Materials Engineering, also in Bremen. Their results are published in English in the journal Angewandte Chemie.

The bodys own immune system is being used more and more often in medical treatments for cancer, but not always successfully.

The team discovered that cancer cells are very sensitive to nano-particles of copper oxides, which dissolve in the body and are fatal to the cancer cells. However, using copper oxide particles alone did not prevent the cancer from returning.

But when the nano-particles are coupled with the bodys own immune system, and found that not only were the cancer cells killed, the bodys immune system learned to attack cancer cells on its own, and they were never able to re-establish. To test the result, after treatment with the reinforced immune cells, the team re-injected cancer cells into the now-healthy mice. The immune system in the mice was now able to recognise the cancer, and it was wiped out before it had a chance to take hold.

The team argues that the technique could be effective in a range of different cancers those caused by a mutation in the tumour protein TP53. Those include forms of cancer of the breast, lung, ovary and colon.

As far as I can tell, this is the first time that metal oxides have been used to fight cancer cells effectively in living models, commented Professor Stefaan Soenen of the department of imaging and pathology of the KULeuven. Now we want to look at other metal nano-particles and identify which particles influence which types of cancer. That would result in an extensive database.

The team now plans to test cancer cells based on tissue taken from cancer patients. If the results are as positive, Prof. Soenen plans to set up a clinical trial using human subjects.

Nano-medicine is becoming more and more popular in the US and Asia, but Europe is falling behind. It is a challenge to achieve progress, since physicians and engineers often speak a different language. We need more inter-disciplinary cooperation, to allow us better to understand each other, and to build upon each others knowledge.

Alan HopeThe Brussels Times

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Researchers combine immunotherapy with nano-particles to kill cancer cells - The Brussels Times