Category Archives: Biochemistry

CLAREMONT, Calif.--(BUSINESS WIRE)--Synedgen, a biotechnology company using glycopolymer chemistry to develop drugs that enhance and control signaling in the innate immune system, today announced that UNSW in partnership with Synedgen has been awarded an A$600,633, 3-year, research grant from the Australian Research Council (ARC) to advance knowledge of the biochemical and biophysical structure of the endothelial glycocalyx. The resulting study will be the first to explore how charged glycopolymers interact with the endothelial glycocalyx with the goal of mapping the lifecycle of the network of membrane-bound proteoglycans and glycoprotein.

Synedgen is developing molecules that interact with the glycocalyx to control the movement of cells and molecules across the endothelium and we are keen to deepen the understanding of the dynamic structure of and implicit role of the endothelial glycocalyx in innate immune signaling. This ARC-funded project aims to address this knowledge deficit by mechanistically elucidating and describing the dynamic lifecycle of the endothelial glycocalyx, said Shenda Baker, Ph.D., President and Chief Executive Officer of Synedgen. We are grateful to the ARC for this grant and honored to be working with Drs. Megan Lord and John Whitelock of the University of New South Wales, experts in proteoglycan interactions and signaling. We anticipate that results of these efforts can be leveraged to inform the development of targeted molecules to treat diseases involving the endothelial glycocalyx including cardiovascular and pulmonary diseases, stroke and traumatic brain injury.

We still have much to learn about the structure and dynamics of the endothelial glycocalyx, a network of proteoglycans and glycosaminoglycans anchored at the cell surface, said Megan Lord, Ph.D., lead PI on the grant. Synedgens glycopolymers will enable us to study interactions at the endothelial interface and develop new ways to support endothelial functions.

Synedgen believes the findings of the ARC-sponsored project will inform the companys future research and development activities over the next 3-7 years.

Synedgens CEO, Shenda Baker, gave a related keynote lecture at the Pan Pacific Connective Tissue Societies Symposium on November 25, 2020, titled, Glycopolymer interactions with the glycocalyx to modulate innate immune responses after dermal injury. The 12th Pan Pacific Connective Tissue Societies Symposium, a virtual event held in November 2020, was held in conjunction with the scientific meetings of the Australian Wound & Tissue Repair Society (AWTRS) and Matrix Biology Society of Australia and New Zealand (MBSANZ).

About Synedgen

Synedgen is a biotechnology company using glycochemistry to develop drugs that enhance and mimic the innate immune system. The companys lead development candidate is SYGN305 for gastrointestinal mucositis, where a large unmet need exists to prevent intestinal radiation injury, the single most important dose-limiting factor in cancer radiotherapy. Synedgens glycopolymer platform has already generated five FDA 510(k)-cleared therapeutics, one OTC drug, one veterinary indexed drug, and an out-licensed Phase 2 program, to Synspira, for the potential treatment of pulmonary complications of cystic fibrosis. Synedgen has research and manufacturing facilities in Claremont, California. For more information please visit http://www.synedgen.com.

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Synedgen Partnership with the University of New South Wales Receives Australian Research Council (ARC) Grant - Business Wire

The main protease (Mpro) of SARS-CoV-2 is a key antiviral drug target. While most Mpro inhibitors have a -lactam glutamine surrogate at the P1 position, we recently found that several Mpro inhibitors have hydrophobic moieties at the P1 site, including calpain inhibitors II and XII, which are also active against human cathepsin L, a host protease that is important for viral entry. In this study, we solved x-ray crystal structures of Mpro in complex with calpain inhibitors II and XII and three analogs of GC-376. The structure of Mpro with calpain inhibitor II confirmed that the S1 pocket can accommodate a hydrophobic methionine side chain, challenging the idea that a hydrophilic residue is necessary at this position. The structure of calpain inhibitor XII revealed an unexpected, inverted binding pose. Together, the biochemical, computational, structural, and cellular data presented herein provide new directions for the development of dual inhibitors as SARS-CoV-2 antivirals.

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Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L - Science...

November 30, 2020

Editor's note:This story is part of a series of profiles ofnotable fall 2020 graduates.

Fall 2020 graduate Cindy Bonilla-Cirocco says her peers should always keep an open mind about their studies and career path. Fall 2020 graduate Cindy Bonilla-Cirocco will be receiving her PhD in Latin American literature and culture in December. Earlier this year, she successfully defended her dissertation on the Caliwood movement of the 1970s in Colombian cinema. Download Full Image

I would encourage students not to limit themselves and to do their research about what other options are out there, said Bonilla-Cirocco, who will be receiving her PhD in Latin American literature and culture. You never know when you may find a great opportunity you werent expecting if you keep yourself open to it!

Luckily, Bonilla-Cirocco took her own advice.

Midway through the process of researching and writing her dissertation, she enrolled in a Latin American film course taught by Spanish Professor Cynthia Tompkins that changed the course of her doctoral studies. After writing a paper about the 2015 documentary film "Todo comenz por el fin (It All Started at the End)" by Colombian director Luis Ospina, Bonilla-Cirocco switched her dissertation topic from Latin American graphic novels to Colombian cinema.

I was immediately drawn to his work and wanted to know more, she said. It was a drastic change, and I had to essentially learn all about Latin American cinema, as well as Colombian cinema, on the fly as I wrote my dissertation.

With Tompkins assistance, Bonilla-Cirocco published her paper about It All Started at the End in the academic journalConfluencia from the University of Northern Colorado. She then developed it into her dissertation by including additional research and analysis on Ospina and other members of the young and subversive Caliwood filmmaking collective that he was a part of in the 1970s, including Carlos Mayolo.

Bonilla-Cirocco succeeds in highlighting the political commitment of these filmmakers, who risked international success by rejecting and lampooning the Colombian pornomiseria movies of the time that profited from showing the most sordid aspects of the third world, both in terms of the production of a movie as well as penning a manifesto of their own, said Tompkins, who also served as Bonilla-Cirocco's dissertation committee chair.

Bonilla-Cirocco said she was determined to convey her newly discovered passion for Colombian cinema in her dissertation, which she successfully defended in October.

This was a challenging task, and at times I felt overwhelmed, but I knew what my end goal was and I refused to let so many years of hard work and intellectual growth go to waste, Bonilla-Cirocco said. Finishing my dissertation is one of the proudest moments of my life.

During her time at ASU, Bonilla-Cirocco volunteered at various events, such as the School of International Letters and Cultures Language Fair and Homecoming, where she represented SILCs Spanish Department. She also was a member of the organizing committee for ASUs Hispanic Heritage Month celebration, which involved connecting with Spanish-speaking communities around the Valley to showcase various cultures. Bonilla-Cirocco, who was raised in Colombia, served as a liaison to the local Colombian community in particular.

Cindy has an incredible work ethic. She is unassuming, diligent, always well prepared and very professional, said Associate Professor of Spanish Jess Rosales. I believe that Cindy is a socially concerned scholar who is committed to sharing her knowledge, not only with fellow academics, but also with underprivileged communities unable to receive a university education.

Bonilla-Cirocco chose to complete her doctoral studies at ASU after first earning her bachelors degree due to the distinguished reputation of the Spanish program. Doing so allowed her to accept a position as a teaching assistant for Spanish courses at all levels, as well as working as a research assistant for Regents Professor of Spanish David William Foster.

Foster was the original chair of Bonilla-Cirocco's dissertation committee before he diedearlier this year, and he had served as a mentor to her for many years.

There was no better example of a person who was deeply committed to and passionate about his work and his students, Bonilla-Cirocco said. I am honored to have known and worked under him, and I learned things from him that I will remember for the rest of my life."

Bonilla-Cirocco is grateful that Tompkins, who was a member of her dissertation committee at the time, was able to step up into the role of chair and guide her to completing her dissertation and graduating this fall.

While the dissertation is a tribute to the Caliwood movement in general, Bonilla-Cirocco's work is essential in filling a gap in Colombian national cinema, Tompkins said. Im happy to report that Cindy managed to convey her project to Ospina, one of the directors she wrote about, prior to his death in 2019.

After graduating in December, Bonilla-Cirocco hopes to pursue a job in the Foreign Service with the U.S. Department of State. Shes also considering work in academia.

When I entered (the School of International Letters and Cultures) as a graduate student, a professor told me that these would be the best years of my life. I can say now, without a shadow of doubt, that these years here at (ASU) have been the most memorable so far, Bonilla-Cirocco said. During my time at (the school), I grew as an individual, as an intellectual and as an educator.

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Aid to Navajo Nation is aim of talented biochemistry graduate - ASU Now

DNA synthesis can be used to generate true random numbers. Credit: Isabelle Benz

ETH scientists have generated a huge true random number using DNA synthesis. It is the first time that a number of this magnitude has been created by biochemical means.

True random numbers are required in fields as diverse as slot machines and data encryption. These numbers need to be truly random, such that they cannot even be predicted by people with detailed knowledge of the method used to generate them.

As a rule, they are generated using physical methods. For instance, thanks to the tiniest high-frequency electron movements, the electrical resistance of a wire is not constant but instead fluctuates slightly in an unpredictable way. That means measurements of this background noise can be used to generate true random numbers.

Now, for the first time, a research team led by Robert Grass, Professor at the Institute of Chemical and Bioengineering, has described a non-physical method of generating such numbers: one that uses biochemical signals and actually works in practice. In the past, the ideas put forward by other scientists for generating random numbers by chemical means tended to be largely theoretical.

For this new approach, the ETH researchers apply the synthesis of DNA molecules, an established chemical research method frequently employed over many years. It is traditionally used to produce a precisely defined DNA sequence. In this case, however, the research team built DNA molecules with 64 building block positions, in which one of the four DNA bases A, C, G and T was randomly located at each position. The scientists achieved this by using a mixture of the four building blocks, rather than just one, at every step of the synthesis.

As a result, a relatively simple synthesis produced a combination of approximately three quadrillion individual molecules. The scientists subsequently used an effective method to determine the DNA sequence of five million of these molecules. This resulted in 12 megabytes of data, which the researchers stored as zeros and ones on a computer.

However, an analysis showed that the distribution of the four building blocks A, C, G and T was not completely even. Either the intricacies of nature or the synthesis method deployed led to the bases G and T being integrated more frequently in the molecules than A and C. Nonetheless, the scientists were able to correct this bias with a simple algorithm, thereby generating perfect random numbers.

The main aim of ETH Professor Grass and his team was to show that random occurrences in chemical reaction can be exploited to generate perfect random numbers. Translating the finding into a direct application was not a prime concern at first. Compared with other methods, however, ours has the advantage of being able to generate huge quantities of randomness that can be stored in an extremely small space, a single test tube, Grass says. We can read out the information and reinterpret it in digital form at a later date. This is impossible with the previous methods.

Reference: DNA synthesis for true random number generation by Linda C. Meiser, Julian Koch, Philipp L. Antkowiak, Wendelin J. Stark, Reinhard Heckel and Robert N. Grass, 18 November 2020,Nature Communications.DOI: 10.1038/s41467-020-19757-y

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Biochemical Random Number: Scientists Have Generated a Huge True Random Number Using DNA Synthesis - SciTechDaily

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AutomaticSemi-automatic

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Pet HospitalResearch CenterInspection and Quarantine DepartmentsOther

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Global Veterinary Biochemistry Analyzers Market Research Report 2020 2026

Chapter 1 Veterinary Biochemistry Analyzers Market Overview

Chapter 2 Global Economic Impact on Industry

Chapter 3 Global Market Competition by Manufacturers

Chapter 4 Global Production, Revenue (Value) by Region

Chapter 5 Global Supply (Production), Consumption, Export, Import by Regions

Chapter 6 Global Production, Revenue (Value), Price Trend by Type

Chapter 7 Global Market Analysis by Application

Chapter 8 Manufacturing Cost Analysis

Chapter 9 Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10 Marketing Strategy Analysis, Distributors/Traders

Chapter 11 Market Effect Factors Analysis

Chapter 12 Global Veterinary Biochemistry Analyzers Market Forecast

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Comprehensive Report on Veterinary Biochemistry Analyzers Market 2020 | Size, Growth, Demand, Opportunities & Forecast To 2026 | AMS Alliance,...

IndustryGrowthInsights, one of the worlds prominent market research firms has announced a novel report on the Laboratory Biochemical Reagent market. The report is integrated with imperative insights on the market which will support the clients to make precise business decisions. This research will help both existing and new aspirants for Global Laboratory Biochemical Reagent Market to figure out and study market requirements, market size, and competition. The report incorporates data regarding the supply and demand situation, the competitive scenario, and the challenges for market growth, market opportunities, and the threats encountered by key players during the forecast period of 2020-2027.

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Impact of COVID-19

The report also incorporates the impact of the ongoing global crisis i.e. COVID-19 on the Laboratory Biochemical Reagent market and explains how the future is going to unfold for the global market. The report also provides an analysis of the effects of the pandemic on the global economy. The outbreak has directly affected production and demand disrupted the demand and supply chain. The report also computes the financial impact on firms and financial markets. IndustryGrowthInsights has accumulated insights from various delegates of the industry and got involved in the primary and secondary research to offer the clients data & strategies to combat the market challenges during and after the COVID-19 pandemic.

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Some of the major companies that are covered in this report:

Beckton, Dickinson & CompanyMerck & Co. Inc.Abbott LaboratoriesAgilent Technologies, Inc.Waters CorporationSiemens HealthineersThermo Fisher Scientific IncBio-Rad LaboratoriesRoche Holding AGJohnson & Johnson

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HospitalsDiagnostic CentersAcademics and ResearchPharma and Biotech CompaniesCROs

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PCR Reagent KitsCell and Tissue Culture ReagentsElectrophoresis ReagentsChromatography ReagentsOthers

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Executive Summary

Assumptions and Acronyms Used

Research Methodology

Laboratory Biochemical Reagent Market Overview

Global Laboratory Biochemical Reagent Market Analysis and Forecast by Type

Global Laboratory Biochemical Reagent Market Analysis and Forecast by Application

Global Laboratory Biochemical Reagent Market Analysis and Forecast by Sales Channel

Global Laboratory Biochemical Reagent Market Analysis and Forecast by Region

North America Laboratory Biochemical Reagent Market Analysis and Forecast

Latin America Laboratory Biochemical Reagent Market Analysis and Forecast

Europe Laboratory Biochemical Reagent Market Analysis and Forecast

Asia Pacific Laboratory Biochemical Reagent Market Analysis and Forecast

Asia Pacific Laboratory Biochemical Reagent Market Size and Volume Forecast by Application

Middle East & Africa Laboratory Biochemical Reagent Market Analysis and Forecast

Competition Landscape

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Laboratory Biochemical Reagent Market ? What Factors Will Drive The Market In Upcoming Years And How It Is Going To Impact On Global Industry |...