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Category Archives: Biochemistry

Heparin Market to Hit USD 11.43 Billion with a CAGR of 3.9% by 2027; Rising Prevalence of Chronic Diseases to Propel Business, states Fortune Business…

Pune, India, Dec. 10, 2020 (GLOBE NEWSWIRE) -- The global heparin market size is expected to reach USD 11.43 billion by 2027, exhibiting a CAGR of 3.9% during the forecast period. The market size stood at USD 8.39 billion in 2019. The increasing cases of cardiovascular diseases such as deep vein thrombosis & pulmonary embolism are expected to spur demand for heparin in the forthcoming years, states Fortune Business Insights, in a report. The market size in North America stood at USD 4.28 billion in 2019. The growth in the region is attributed to the prevalence of cardiovascular diseases such as pulmonary embolism. The higher adoption of advanced heparin products will have an excellent effect on the market in the region.

Key Development:

May 2019: Pfizer, Inc. announced that it has received the approval from the U.S. FDA for the administration of its heparin product offering, Fragmin to minimize the recurrence of symptomatic venous thromboembolism (VTE) in pediatric patients aged one month and above.

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Rising Incidence of Chronic Disorders to Incite Business Development

The increasing prevalence of cardiovascular diseases around the world, including heart attacks and strokes will spur opportunities for the market. As per the American Heart Association (AHA) Heart Disease and Stroke Statistics, an estimated 5.3 million Americans suffered from atrial fibrillation in 2019.

The growing demand for heparin among patients can have an excellent impact on the market. As per the Centers for Disease Control and Prevention, coronary heart disease is the most common type of heart disease, killing 365,914 people in 2017.4. About18.2 million adultsage 20 and older have CAD (about 6.7%). Moreover, 2 in 10 deaths from CAD happen in adults less than 65 years old. The increasing awareness about the benefits of heparin in the treatment and management of heart diseases will improve the prospects of the market in the foreseeable future.

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Minimal Impact on the Market During COVID-19

The limitations on non-essential medical procedures and consultations has had a drastic impact on the global market amid COVID-19. The healthcare industry has observed a decline in other medical services besides coronavirus. The increased emphasis on COVIDs vaccine has reduced the demand for other therapeutics.

Furthermore, the lack of supply and production of heparin will simultaneously limit the scope of the market. However, government initiatives, including heavy investments and free medical aid will influence the healthy growth of the market in the time of the pandemic.

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High Adoption of Advanced Products to Boost Market in North America

The market size in North America stood at USD 4.28 billion in 2019. The growth in the region is attributed to the prevalence of cardiovascular diseases such as pulmonary embolism. The higher adoption of advanced heparin products will have an excellent effect on the market in the region.

The increasing healthcare expenditure is expected to foster the healthy growth of the market in North America. The presence of major companies can further enhance the development of the market in the region. Europe is expected to hold the largest share owing to the acceptance of technologically advanced products in the region. The rising number of patients suffering from a range of cardiovascular diseases will further spur opportunities in the region.

Asia Pacific is expected to experience a rapid growth rate owing to the growing patient population. The surging healthcare expenditure in the developing nations will have a tremendous effect on the market in Asia Pacific.

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Heparin Market to Hit USD 11.43 Billion with a CAGR of 3.9% by 2027; Rising Prevalence of Chronic Diseases to Propel Business, states Fortune Business...

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Automated Biochemistry Analyzers Industry Research Report, Growth Trends and Competitive Analysis 2020-2027: Abbott, Danaher, Hitachi, Roche, Siemens,…

This report studies theAutomated Biochemistry Analyzersmarketwith many aspects of the industry like the market size, market status, market trends and forecast, the report also provides brief information of the competitors and the specific growth opportunities with key market drivers. Find the complete Automated Biochemistry Analyzers market analysis segmented by companies, region, type and applications in the report.

New vendors in the market are facing tough competition from established international vendors as they struggle with technological innovations, reliability and quality issues. The report will answer questions about the current market developments and the scope of competition, opportunity cost and more.

The major players covered in Automated Biochemistry Analyzers Markets: Abbott, Danaher, Hitachi, Roche, Siemens, Thermo Fisher Scientific, and more

The final report will add the analysis of the Impact of Covid-19 in this report Automated Biochemistry Analyzers industry.

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Automated Biochemistry AnalyzersMarket continues to evolve and expand in terms of the number of companies, products, and applications that illustrates the growth perspectives. The report also covers the list of Product range and Applications with SWOT analysis, CAGR value, further adding the essential business analytics. Automated Biochemistry Analyzers Market research analysis identifies the latest trends and primary factors responsible for market growth enabling the Organizations to flourish with much exposure to the markets.

This report focuses on the globalAutomated Biochemistry Analyzersstatus, future forecast, growth opportunity, key market and key players. The study objectives are to present the Automated Biochemistry Analyzers development inUnited States, Europe, China, Japan, Southeast Asia, India, and Central & South America.

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TheAutomated Biochemistry Analyzersmarket research report completely covers the vital statistics of the capacity, production, value, cost/profit, supply/demand import/export, further divided by company and country, and by application/type for best possible updated data representation in the figures, tables, pie chart, and graphs. These data representations provide predictive data regarding the future estimations for convincing market growth. The detailed and comprehensive knowledge about our publishers makes us out of the box in case of market analysis.

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Chapter 1:GlobalAutomated Biochemistry AnalyzersMarket Overview

Chapter 2:Automated Biochemistry Analyzers Market Data Analysis

Chapter 3:Automated Biochemistry Analyzers Technical Data Analysis

Chapter 4:Automated Biochemistry Analyzers Government Policy and News

Chapter 5:Global Automated Biochemistry Analyzers Market Manufacturing Process and Cost Structure

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Chapter 7:Automated Biochemistry Analyzers Key Manufacturers

Chapter 8:Up and Down Stream Industry Analysis

Chapter 9:Marketing Strategy -Automated Biochemistry Analyzers Analysis

Chapter 10:Automated Biochemistry Analyzers Development Trend Analysis

Chapter 11:Global Automated Biochemistry Analyzers Market New Project Investment Feasibility Analysis

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Automated Biochemistry Analyzers Industry Research Report, Growth Trends and Competitive Analysis 2020-2027: Abbott, Danaher, Hitachi, Roche, Siemens,...

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Synedgen Partnership with the University of New South Wales Receives Australian Research Council (ARC) Grant – Business Wire

CLAREMONT, Calif.--(BUSINESS WIRE)--Synedgen, a biotechnology company using glycopolymer chemistry to develop drugs that enhance and control signaling in the innate immune system, today announced that UNSW in partnership with Synedgen has been awarded an A$600,633, 3-year, research grant from the Australian Research Council (ARC) to advance knowledge of the biochemical and biophysical structure of the endothelial glycocalyx. The resulting study will be the first to explore how charged glycopolymers interact with the endothelial glycocalyx with the goal of mapping the lifecycle of the network of membrane-bound proteoglycans and glycoprotein.

Synedgen is developing molecules that interact with the glycocalyx to control the movement of cells and molecules across the endothelium and we are keen to deepen the understanding of the dynamic structure of and implicit role of the endothelial glycocalyx in innate immune signaling. This ARC-funded project aims to address this knowledge deficit by mechanistically elucidating and describing the dynamic lifecycle of the endothelial glycocalyx, said Shenda Baker, Ph.D., President and Chief Executive Officer of Synedgen. We are grateful to the ARC for this grant and honored to be working with Drs. Megan Lord and John Whitelock of the University of New South Wales, experts in proteoglycan interactions and signaling. We anticipate that results of these efforts can be leveraged to inform the development of targeted molecules to treat diseases involving the endothelial glycocalyx including cardiovascular and pulmonary diseases, stroke and traumatic brain injury.

We still have much to learn about the structure and dynamics of the endothelial glycocalyx, a network of proteoglycans and glycosaminoglycans anchored at the cell surface, said Megan Lord, Ph.D., lead PI on the grant. Synedgens glycopolymers will enable us to study interactions at the endothelial interface and develop new ways to support endothelial functions.

Synedgen believes the findings of the ARC-sponsored project will inform the companys future research and development activities over the next 3-7 years.

Synedgens CEO, Shenda Baker, gave a related keynote lecture at the Pan Pacific Connective Tissue Societies Symposium on November 25, 2020, titled, Glycopolymer interactions with the glycocalyx to modulate innate immune responses after dermal injury. The 12th Pan Pacific Connective Tissue Societies Symposium, a virtual event held in November 2020, was held in conjunction with the scientific meetings of the Australian Wound & Tissue Repair Society (AWTRS) and Matrix Biology Society of Australia and New Zealand (MBSANZ).

About Synedgen

Synedgen is a biotechnology company using glycochemistry to develop drugs that enhance and mimic the innate immune system. The companys lead development candidate is SYGN305 for gastrointestinal mucositis, where a large unmet need exists to prevent intestinal radiation injury, the single most important dose-limiting factor in cancer radiotherapy. Synedgens glycopolymer platform has already generated five FDA 510(k)-cleared therapeutics, one OTC drug, one veterinary indexed drug, and an out-licensed Phase 2 program, to Synspira, for the potential treatment of pulmonary complications of cystic fibrosis. Synedgen has research and manufacturing facilities in Claremont, California. For more information please visit http://www.synedgen.com.

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Synedgen Partnership with the University of New South Wales Receives Australian Research Council (ARC) Grant - Business Wire

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Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L – Science…

The main protease (Mpro) of SARS-CoV-2 is a key antiviral drug target. While most Mpro inhibitors have a -lactam glutamine surrogate at the P1 position, we recently found that several Mpro inhibitors have hydrophobic moieties at the P1 site, including calpain inhibitors II and XII, which are also active against human cathepsin L, a host protease that is important for viral entry. In this study, we solved x-ray crystal structures of Mpro in complex with calpain inhibitors II and XII and three analogs of GC-376. The structure of Mpro with calpain inhibitor II confirmed that the S1 pocket can accommodate a hydrophobic methionine side chain, challenging the idea that a hydrophilic residue is necessary at this position. The structure of calpain inhibitor XII revealed an unexpected, inverted binding pose. Together, the biochemical, computational, structural, and cellular data presented herein provide new directions for the development of dual inhibitors as SARS-CoV-2 antivirals.

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Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L - Science...

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Aid to Navajo Nation is aim of talented biochemistry graduate – ASU Now

November 30, 2020

Editor's note:This story is part of a series of profiles ofnotable fall 2020 graduates.

Fall 2020 graduate Cindy Bonilla-Cirocco says her peers should always keep an open mind about their studies and career path. Fall 2020 graduate Cindy Bonilla-Cirocco will be receiving her PhD in Latin American literature and culture in December. Earlier this year, she successfully defended her dissertation on the Caliwood movement of the 1970s in Colombian cinema. Download Full Image

I would encourage students not to limit themselves and to do their research about what other options are out there, said Bonilla-Cirocco, who will be receiving her PhD in Latin American literature and culture. You never know when you may find a great opportunity you werent expecting if you keep yourself open to it!

Luckily, Bonilla-Cirocco took her own advice.

Midway through the process of researching and writing her dissertation, she enrolled in a Latin American film course taught by Spanish Professor Cynthia Tompkins that changed the course of her doctoral studies. After writing a paper about the 2015 documentary film "Todo comenz por el fin (It All Started at the End)" by Colombian director Luis Ospina, Bonilla-Cirocco switched her dissertation topic from Latin American graphic novels to Colombian cinema.

I was immediately drawn to his work and wanted to know more, she said. It was a drastic change, and I had to essentially learn all about Latin American cinema, as well as Colombian cinema, on the fly as I wrote my dissertation.

With Tompkins assistance, Bonilla-Cirocco published her paper about It All Started at the End in the academic journalConfluencia from the University of Northern Colorado. She then developed it into her dissertation by including additional research and analysis on Ospina and other members of the young and subversive Caliwood filmmaking collective that he was a part of in the 1970s, including Carlos Mayolo.

Bonilla-Cirocco succeeds in highlighting the political commitment of these filmmakers, who risked international success by rejecting and lampooning the Colombian pornomiseria movies of the time that profited from showing the most sordid aspects of the third world, both in terms of the production of a movie as well as penning a manifesto of their own, said Tompkins, who also served as Bonilla-Cirocco's dissertation committee chair.

Bonilla-Cirocco said she was determined to convey her newly discovered passion for Colombian cinema in her dissertation, which she successfully defended in October.

This was a challenging task, and at times I felt overwhelmed, but I knew what my end goal was and I refused to let so many years of hard work and intellectual growth go to waste, Bonilla-Cirocco said. Finishing my dissertation is one of the proudest moments of my life.

During her time at ASU, Bonilla-Cirocco volunteered at various events, such as the School of International Letters and Cultures Language Fair and Homecoming, where she represented SILCs Spanish Department. She also was a member of the organizing committee for ASUs Hispanic Heritage Month celebration, which involved connecting with Spanish-speaking communities around the Valley to showcase various cultures. Bonilla-Cirocco, who was raised in Colombia, served as a liaison to the local Colombian community in particular.

Cindy has an incredible work ethic. She is unassuming, diligent, always well prepared and very professional, said Associate Professor of Spanish Jess Rosales. I believe that Cindy is a socially concerned scholar who is committed to sharing her knowledge, not only with fellow academics, but also with underprivileged communities unable to receive a university education.

Bonilla-Cirocco chose to complete her doctoral studies at ASU after first earning her bachelors degree due to the distinguished reputation of the Spanish program. Doing so allowed her to accept a position as a teaching assistant for Spanish courses at all levels, as well as working as a research assistant for Regents Professor of Spanish David William Foster.

Foster was the original chair of Bonilla-Cirocco's dissertation committee before he diedearlier this year, and he had served as a mentor to her for many years.

There was no better example of a person who was deeply committed to and passionate about his work and his students, Bonilla-Cirocco said. I am honored to have known and worked under him, and I learned things from him that I will remember for the rest of my life."

Bonilla-Cirocco is grateful that Tompkins, who was a member of her dissertation committee at the time, was able to step up into the role of chair and guide her to completing her dissertation and graduating this fall.

While the dissertation is a tribute to the Caliwood movement in general, Bonilla-Cirocco's work is essential in filling a gap in Colombian national cinema, Tompkins said. Im happy to report that Cindy managed to convey her project to Ospina, one of the directors she wrote about, prior to his death in 2019.

After graduating in December, Bonilla-Cirocco hopes to pursue a job in the Foreign Service with the U.S. Department of State. Shes also considering work in academia.

When I entered (the School of International Letters and Cultures) as a graduate student, a professor told me that these would be the best years of my life. I can say now, without a shadow of doubt, that these years here at (ASU) have been the most memorable so far, Bonilla-Cirocco said. During my time at (the school), I grew as an individual, as an intellectual and as an educator.

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Aid to Navajo Nation is aim of talented biochemistry graduate - ASU Now

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Biochemical Random Number: Scientists Have Generated a Huge True Random Number Using DNA Synthesis – SciTechDaily

DNA synthesis can be used to generate true random numbers. Credit: Isabelle Benz

ETH scientists have generated a huge true random number using DNA synthesis. It is the first time that a number of this magnitude has been created by biochemical means.

True random numbers are required in fields as diverse as slot machines and data encryption. These numbers need to be truly random, such that they cannot even be predicted by people with detailed knowledge of the method used to generate them.

As a rule, they are generated using physical methods. For instance, thanks to the tiniest high-frequency electron movements, the electrical resistance of a wire is not constant but instead fluctuates slightly in an unpredictable way. That means measurements of this background noise can be used to generate true random numbers.

Now, for the first time, a research team led by Robert Grass, Professor at the Institute of Chemical and Bioengineering, has described a non-physical method of generating such numbers: one that uses biochemical signals and actually works in practice. In the past, the ideas put forward by other scientists for generating random numbers by chemical means tended to be largely theoretical.

For this new approach, the ETH researchers apply the synthesis of DNA molecules, an established chemical research method frequently employed over many years. It is traditionally used to produce a precisely defined DNA sequence. In this case, however, the research team built DNA molecules with 64 building block positions, in which one of the four DNA bases A, C, G and T was randomly located at each position. The scientists achieved this by using a mixture of the four building blocks, rather than just one, at every step of the synthesis.

As a result, a relatively simple synthesis produced a combination of approximately three quadrillion individual molecules. The scientists subsequently used an effective method to determine the DNA sequence of five million of these molecules. This resulted in 12 megabytes of data, which the researchers stored as zeros and ones on a computer.

However, an analysis showed that the distribution of the four building blocks A, C, G and T was not completely even. Either the intricacies of nature or the synthesis method deployed led to the bases G and T being integrated more frequently in the molecules than A and C. Nonetheless, the scientists were able to correct this bias with a simple algorithm, thereby generating perfect random numbers.

The main aim of ETH Professor Grass and his team was to show that random occurrences in chemical reaction can be exploited to generate perfect random numbers. Translating the finding into a direct application was not a prime concern at first. Compared with other methods, however, ours has the advantage of being able to generate huge quantities of randomness that can be stored in an extremely small space, a single test tube, Grass says. We can read out the information and reinterpret it in digital form at a later date. This is impossible with the previous methods.

Reference: DNA synthesis for true random number generation by Linda C. Meiser, Julian Koch, Philipp L. Antkowiak, Wendelin J. Stark, Reinhard Heckel and Robert N. Grass, 18 November 2020,Nature Communications.DOI: 10.1038/s41467-020-19757-y

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Biochemical Random Number: Scientists Have Generated a Huge True Random Number Using DNA Synthesis - SciTechDaily

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