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Valerie Cruz to Play Detective on The Following

Posted: August 16, 2013 at 3:22 pm

Another new face is set to join The Following.

With Sam Underwood on board as a new series regular and Connie Nielson set to play a love interest for Kevin Bacon's Ryan Hardy, E! News now confirms that Valerie Cruz will portray Gina Mendez, a detective who works closely with Mike Weston to track a serial killer in New York City.

The veteran actress (Alphas, True Blood, Homeland) will make her debut on the Season 2 premiere, set for some time in early 2014.

Valerie Cruz Pic

We already know that James Purefoy will return to The Following as Joe Carroll, an announcement made official at Comic-Con last month. But it now sounds as if another serial killer will also figure prominently into the storytelling.

Look for the premiere to pick up one year after events on the May finale and for Hardy to be a college professor when we see him again.

Source:
http://www.tvfanatic.com/2013/08/valerie-cruz-to-play-detective-on-the-following/

Recommendation and review posted by G. Smith

Glee Season 5 Teaser: Let’s Get Started!

Posted: August 16, 2013 at 2:46 pm

The death of Cory Monteith has cast an understandable dark cloud over Glee Season 5.

In an interview this week, creator Ryan Murphy said the show would pay tribute to both the actor and the character of Finn on Episode 3, revealing that the latter will NOT die of a drug overdose.

As for what we can expect from new episodes? Fox has released the first teaser for the September 26th premiere, which doesn't reveal very much, aside from a fun one and an enthusiastic Will Schuester.

It will clearly be an unusual fall ahead for the series, but try to get excited for it via the following promo:

Source:
http://www.tvfanatic.com/2013/08/glee-season-5-teaser-lets-get-started/

Recommendation and review posted by G. Smith

True Blood Season Finale Clips: A Surprise and A Smooch

Posted: August 16, 2013 at 2:00 pm

Viewers will be in for a surprise and an unexpected smooth on this Sunday's True Blood Season 6 finale.

Following an uneven episode, that dedicated over half its time to the funeral of Terry Bellefleur, the action will pick up immediately on "Radioactive," as Sookie goes for a stroll with a suddenly calm and understanding Alcide. They talk about Jason and death and life and bond like never before.

With their clothes on, it should be noted. Watch a sneak peek now:

True Blood Season Finale Clip: A Pleasant Surprise

Elsewhere, Jason will continue to get (VERY) close to Violet, while Sookie will end up meeting this vampire. In the most intimate of ways:

True Blood Season Finale Sneak Peek: Meeting Violet

Visit TV Fanatic shortly after Sunday night's finale airs for a detailed recap and review of how it all ends.

Source:
http://www.tvfanatic.com/2013/08/true-blood-season-finale-clips-a-surprise-and-a-smooch/

Recommendation and review posted by G. Smith

Emmy Watch: Anna Chlumsky Talks Nomination, Veep Season 3, Motherhood and More!

Posted: August 16, 2013 at 12:00 pm

It’s good to be Anna Chlumsky right now.

Shortly after giving birth to her first child in July, the actress got word that she received her first Emmy nomination for her role as Chief of Staff Amy Brookheimer on Veep, who spends her time trying to keep control of chaos magnet Selina Meyer, the Vice President of the United States, played by Emmy winner Julia Louis-Dreyfus.

In the first of TV Fanatic's Emmy Watch series, I talked to Chlumsky to find out what she thinks of her nomination and her hopes for Amy in the third season of Veep.

-------------------------------------------

TV Fanatic: You're having a good summer with your new baby but you also received your first Emmy nomination! Congratulations on that.
Anna Chlumsky: Thank you so much. That was a pretty crazy week.

TVF: I bet. When did you find out about the nomination? Did you get woken up by phone calls with the news?
AC: No, I was up because I was feeding my daughter. She was a week old at the time. My manager called me. It being so early, I kind of knew. My husband had reminded me that the announcement would be that morning, but we weren't really having success in watching them online. It wasn't really the top thing that I was thinking about, and then my manager called me.

TVF: Wow. Do you get to pick the episode you wanted to submit?
AC: I did. I find that to be kind of funny especially in our show, which is such an ensemble show. I feel like you would want to just send the entire season. It's hard to choose one. But yeah, we chose our episode. I think it's episode eight [from the first season]. I think it’s a good one.

Anna Chlumsky on Veep

TVF: In terms of the second season do you think it was a good time for us to get to know Amy a little bit more since we met her family?
AC: Yeah, I think so. It also speaks to just how married to her work she is. If you keep her in the context of the office I think you get a taste of Amy, but once you take her outside of the office then you realize ‘oh geez, she's really only good at her job and not really good at anything else.’

TVF: What do you think the future holds for her in terms of romance?
AC: I actually don't know how Ed's going to come into play. It seems like it was - and this is really just conjecture - with the campaign brewing, the fundraising genius that he is, he's going to have to be present somehow. Narratively, I don't think they necessarily clicked as much as they were going to click but you never know how long it takes a character to figure that out before the audience does.

TVF: Since the campaign is going to be a big part of the third season, do you think it's a good or bad thing for Amy?
AC: I think she's going to love being part of the campaign. I think she's in a hinky position being the chief of staff because she's got to hold down the fort. I'm sure she would love to be at the forefront of all the excitement of the campaign as well. I think that could be one of her struggles is balancing being in the current administration with how it would interplay with what she would want to do with the campaign.

TVF: Given you being a new mother, do you think Amy would make a good mother?
AC: [laughs] Oh gosh. I wouldn't want to put that on her, honest to God. Just because I know that she's so conflicted about it in the first place. I think that she considers her work her baby, which is even kind of funny considering that she pretended to be with child at one point because of her work. That's the first season reference.

TVF: I do remember that.
AC: I definitely think that she'd like to put number one, number one. If anybody else becomes number one, she's terribly uncomfortable with that. For me it already takes up a lot of that room for her. Amy, then Selina, then gosh, would she have room for anybody else? I don't know.

TVF: This past year you still were dabbling in some drama series like Hannibal. Is that just something you consciously want to do as an actor, making sure you're doing some comedy and some drama?
AC: That's something I definitely do. I think that range and also stretching yourself is vital as an actor. I think that never, ever goes away no matter how busy you are. It is really important to me to play with other roles when I get the chance to.

Also, I personally approach comedy and drama the same way. I feel like scenes and how you face them can happen in both genres and if you’re telling a story, then you're doing your job. I don't really consider myself with mixing of comedy and drama as much as I try to look for different roles when I'm on hiatus from Veep.

TVF: How is motherhood? It's your first child, right?
AC: Yeah. It's new all the time. The learning curve is skyrocketing. There's days I'm like ‘oh my gosh! I have no idea what's happening.’ Then you learn something and you feel a little bit more confident so that's good.

TVF: The big question, of course: are you getting sleep?
AC: I am. There's no way I can complain. My husband and I have figured out a little shift system so both of us can get a good block in. There are no complaints here when it comes to sleep. I know a lot of people have all hours.

Veep returns for its third season in 2014. The 65th annual Primetime Emmy Awards airs September 22 on CBS.

Source:
http://www.tvfanatic.com/2013/08/emmy-watch-anna-chlumsky-talks-nomination-veep-season-3-motherho/

Recommendation and review posted by G. Smith

A Short Overview of 3-D Printing in Tissue Engineering

Posted: August 16, 2013 at 7:37 am

Technologies derived from rapid prototyping and 3-D printing will likely play an important role in the future of tissue engineering, just as they are coming to do in many fields:

The field of tissue engineering has deployed several fabrication strategies aimed at bringing cells and structure together to generate tissue. Biomaterial scaffolding - which provides structural support and can be formed into biologically relevant shapes - has been combined with cells to generate hybrid 3-D structures for use as tissue surrogates in vitro and in vivo. Protocols have been developed that enable removal of living cells from native tissues, leaving only a natural scaffolding of extracellular matrix, which can then be re-seeded with cells to reconstruct or partially reconstruct 3-D tissues. Another approach to soft tissue reconstruction has been the development of cell-laden hydrogels, which are often cast into a specific shape and placed into a permissive environment in vitro or in vivo that allows maturation and establishment of tissue-specific characteristics. In recent years, with the advancement of 3-D printing technologies for the on-demand fabrication of complex polymer-based objects, efforts have been underway to adapt 3-D printing technologies and engineer bioprinting instruments that can leverage similar 3-D replication concepts and accommodate the incorporation of living cells.

Organovo's NovoGen MMX Bioprinter precisely dispenses "bio-ink" - tiny building blocks composed of living cells - generating tissues layer-by-layer according to user-defined designs. Built for flexibility, the bioprinter enables fabrication of tissues with a wide array of cellular compositions and geometries; side-by-side comparison of multiple tissue prototypes facilitates optimization and selection of specific designs geared toward a particular application. Working within the confines of an object library, bio-ink building blocks of various shapes, sizes and compositions are assembled into architectures that recapitulate the form of native tissue. Tubes, layered sheets and patterned structures have been bioprinted, yielding 3-D tissues that are free of biomaterial scaffolding and characterized by tissue-like microarchitecture, including the development of intercellular junctions and endothelial networks.

In the short-term, 3-D human tissues are being deployed in the laboratory setting as models of human physiology and pathology; cell-based assays are a mainstay of the drug discovery and development process, and multicellular/multitissue systems may serve as more predictive indicators of clinical outcomes. Longer-term applications of 3-D tissue technologies will extend our knowledge of how to build the smallest functional units of a tissue to the fabrication of larger-scale tissues useful for surgical grafts to repair or replace damaged tissues and organs in the body. What are the next steps in the evolution of bioprinting? The first step is scaling up and down - increasing the resolution of specific features while advancing fabrication hardware and techniques to produce larger-scale tissues. The next, enhancing the complexity of designs - building the tool set that enables conceptual or visual inputs to be translated rapidly to executable bioprinting programs that select from a library of bio-ink building blocks to translate the vision into reality.

Link: http://www.rdmag.com/articles/2013/08/3-d-printing-life-science-applications

Source:
https://www.fightaging.org/archives/2013/08/a-short-overview-of-3-d-printing-in-tissue-engineering.php

Recommendation and review posted by Fredricko

Another Way to Improve Memory in Old Mice

Posted: August 16, 2013 at 7:12 am

In recent years researchers have demonstrated a number of ways to improve memory in old laboratory mice. Here is another:

If you forget where you put your car keys and you can't seem to remember things as well as you used to, the problem may well be with the GluN2B subunits in your NMDA receptors. And don't be surprised if by tomorrow you can't remember the name of those darned subunits. They help you remember things, but you've been losing them almost since the day you were born, and it's only going to get worse. An old adult may have only half as many of them as a younger person.

Cognitive decline with age is a natural part of life, and scientists are tracking the problem down to highly specific components of the brain. Separate from some more serious problems like dementia and Alzheimer's disease, virtually everyone loses memory-making and cognitive abilities as they age. The process is well under way by the age of 40 and picks up speed after that. But of considerable interest: It may not have to be that way. "These are biological processes, and once we fully understand what is going on, we may be able to slow or prevent it."

In recent research [scientists] used a genetic therapy in laboratory mice, in which a virus helped carry complementary DNA into appropriate cells and restored some GluN2B subunits. Tests showed that it helped mice improve their memory and cognitive ability. The NMDA receptor has been known of for decades. [It] plays a role in memory and learning but isn't active all the time - it takes a fairly strong stimulus of some type to turn it on and allow you to remember something. The routine of getting dressed in the morning is ignored and quickly lost to the fog of time, but the day you had an auto accident earns a permanent etching in your memory.

Within the NMDA receptor are various subunits, [and] research keeps pointing back to the GluN2B subunit as one of the most important. Infants and children have lots of them, and as a result are like a sponge in soaking up memories and learning new things. But they gradually dwindle in number with age, and it also appears the ones that are left work less efficiently. "The one thing that does seem fairly clear is that cognitive decline is not inevitable. It's biological, we're finding out why it happens, and it appears there are ways we might be able to slow or stop it, perhaps repair the NMDA receptors. If we can determine how to do that without harm, we will."

Link: http://oregonstate.edu/ua/ncs/archives/2013/aug/cognitive-decline-age-normal-routine-%E2%80%93-not-inevitable

Source:
https://www.fightaging.org/archives/2013/08/another-way-to-improve-memory-in-old-mice.php

Recommendation and review posted by Fredricko


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