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"Three Unique Medical Museums in Northern Italy," Lecture by Marie Dauenheimer, Observatory, Saturday May 1

Posted: April 28, 2010 at 8:14 am


This Saturday night, Marie Dauenheimer--the curator of the "Anatomical Art: Dissection to Illustration" exhibition discussed in yesterday's post--will be on hand at Observatory to deliver an illustrated lecture that "will survey the collections of three unique and often over-looked anatomical museums in Northern Italy." One of the museums discussed will be The Museum of Human Anatomy in Bologna, which houses--among other works--an incredible wax self-portrait of Anna Morandi Manzolini dissecting a brain (c. 1760 ; see above). The other two musems she will discuss will be the fantastic and difficult-to-access University of Florence Museum of Pathological Anatomy and the University of Pavia Museum of Anatomy.

Marie--who also leads tours of medical museums for the Vesalius Trust (as discussed in this recent post)--is an excellent speaker; her lecture on Italian Wax Anatomical Models in European Collections, which she gave about a year ago, was beloved by all, and we are exceptionally pleased to be hosting her again!

Full details follow; hope very much to see you there!

Three Unique Medical Museums in Northern Italy
An illustrated presentation by Marie Dauenheimer of the Vesalius Trust
Date: May 1, 2010
Time: 8:00 P.M.
Admission: $5
Presented by Morbid Anatomy

Tonight’s visual presentation by Marie Dauenheimer will survey the collections of three unique and often over-looked anatomical museums in Northern Italy which Dauenheimer toured as part of last years Vesalius Trust “Art and Anatomy Tour.” First, the University of Florence Museum of Pathological Anatomy, famous for its collection of wax pathological models created in the 19th century, including an amazing life size leper; then The Museum of Human Anatomy in Bologna featuring the work of famed wax modeling team of Anna Morandi Manzolini and her husband Giovanni Manzolini, whose life size wax models inspired Clement Susini and the wax-modeling workshop in Florence (see image above); and lastly the fascinating University of Pavia Museum of Anatomy, which houses the beautiful 18th century frescoed dissection theater, where anatomist Antonio Scarpa. So join us tonight for wine, fellowship, and a virtual and very visual tour of some of the finest and most fascinating medical museums of Italy!

Marie Dauenheimer is a Board Certified Medical Illustrator working in the Washington, DC Metropolitan area. She specializes in creating medical illustrations and animations for educational materials, including posters, brochures, books, websites and interactive media. Since 1997 Marie has organized and led numerous “Art and Anatomy Tours” throughout Europe for the Vesalius Trust. Past tours have explored anatomical museums, rare book collections and dissection theatres in Italy, The Netherlands, Belgium, France, Scotland and England. In addition to illustrating Marie teaches drawing, life drawing and human and animal anatomy at the Art Institute of Washington. Part of Marie’s anatomy class involves study and drawing from cadavers in the Anatomy Lab at Howard University College of Medicine in Washington, DC (for more on that, see this recent post).

You can find out more about this presentation here. You can get directions to Observatory--which is next door to the Morbid Anatomy Library--by clicking here. You can find out more about Observatory here, join our mailing list by clicking here, and join us on Facebook by clicking here. To learn more about Marie's "Anatomical Art: Dissection to Illustration" exhibition, click here. For more on the Vesalius Trust, click here.

Image: Self-portrait of wax modeller Anna Morandi Manzolini dissecting a human brain, Bologna, c. 1760; Via Scienza a Due Voci

Recommendation and review posted by G. Smith

Sarcopenia, Metabolic Syndrome, and Overnutrition

Posted: April 27, 2010 at 8:18 am

This paper outlines the overlap between the ways in which both processes of aging and eating too much lead to the loss of muscle mass and strength: "Sarcopenia, which is defined by the loss of skeletal muscle mass, predisposes skeletal muscle to metabolic dysfunction which can precipitate metabolic disease. Similarly, overnutrition, which is a major health problem in modern society, also causes metabolic dysfunction in skeletal muscle and predisposition to metabolic disease. It is now the prevailing view that both aging and overnutrition negatively impact skeletal muscle metabolic homeostasis through deleterious effects on the mitochondria. Accordingly, interplay between the molecular pathways implicated in aging and overnutrition that induce mitochondrial dysfunction are apparent. Recent work from our laboratory has uncovered the stress-responsive mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) as a new player in the regulation of metabolic homeostasis in skeletal muscle and mitochondrial dysfunction caused by overnutrition. These observations raise the intriguing possibility that MKP-1 may function as a common target in the convergence between sarcopenia and overnutrition in a pathophysiological pathway that leads to a loss of skeletal muscle mitochondrial function." Going the other way, you might recall that calorie restriction helps to maintain muscle mass with age.

View the Article Under Discussion: http://www.impactaging.com/papers/v2/n3/full/100135.html

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Recommendation and review posted by Fredricko

A Look at Progress in Cancer Vaccines

Posted: April 27, 2010 at 8:18 am

Nature looks at the chaotic state of bringing cancer vaccines to trial: "Many first-generation cancer vaccines such as PANVAC, a pancreatic cancer vaccine, were deemed safe but failed to demonstrate that they significantly slowed the progression of cancer. Because cancer-associated antigens - such as those used in Provenge - are also found at low levels in healthy tissue, their ability to trigger a powerful immune response may be blunted. A second generation of vaccines, designed to provoke a stronger immune response, is under development, with some scientists now focusing on antigens that are found only on tumour cells. ... Over the past decade, researchers have reached a deeper understanding of how tumours actively suppress immune responses in their immediate environment, which can dampen responses to cancer vaccines. To overcome this, some therapies currently in development combine the vaccine with chemotherapies that are designed to counteract this immune suppression. ... For some in the field, the struggle to create effective cancer vaccines conjures up memories of the long battle to develop antibody-based therapies, which are now a mainstay of the biotechnology industry. There, too, a series of clinical-trial failures initially soured the field's reputation ... We realized you just have to test a lot of drugs to find one that works, and it's the same for a cancer vaccine."

View the Article Under Discussion: http://www.nature.com/news/2010/100421/full/4641110a.html

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Recommendation and review posted by Fredricko

Beetroot Juice May Boost Stamina

Posted: April 27, 2010 at 8:18 am

(HealthDay News) -- Beetroot juice can boost physical stamina and increase exercise endurance by up to 16 percent, a new British study shows.

The researchers found that nitrate in beetroot juice reduces oxygen uptake to a degree that can't be achieved by any other means. The findings could benefit endurance athletes, elderly people and those with cardiovascular, respiratory or metabolic diseases, the study authors suggest.

The study included eight men, aged 19 to 38, who drank 500 milliliters a day of organic beetroot juice for six consecutive days. They then completed a series of tests on an exercise bike. The same tests were repeated after the men drank the same amount of a placebo (blackcurrant cordial) for six days.

After drinking the beetroot juice, the men were able to cycle for an average of 11.25 minutes -- 92 seconds longer than after consuming the placebo drink. The men also had a lower resting blood pressure after they drank the beetroot juice, the researchers found.

The study was published Aug. 6 in the Journal of Applied Physiology. Read more...



Joint Mender for Joint Care

Recommendation and review posted by Fredricko

Biomarker Studies Could Realize Goal of More Effective and Personalized Cancer Medicine

Posted: April 27, 2010 at 8:18 am

When President Richard Nixon launched the war on cancer in his January 1971 State of the Union, he called for "the same kind of concentrated effort that split the atom and took man to the moon." Yet nearly 40 years and $100 billion in federally funded cancer research later, it seems the lunar landing was a much less daunting task.

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Recommendation and review posted by Fredricko

Sessions on CSC Therapeutics at AACR10

Posted: April 27, 2010 at 8:18 am

There were two poster sessions on Cancer Stem Cell Therapeutics at the 101st Annual Meeting of the American Association for Cancer Research (AACR). The sessions, Cancer Stem Cell Therapeutics 1 and Cancer Stem Cell Therapeutics 2, took place on the morning and afternoon of April 20, 2010 [FriendFeed entry].

Two posters presented in the 2nd session have been highlighted in a news release. See: Alchemia’s HyACT Technology Enhances the Killing of Cancer Stem Cell Populations in Breast and Colorectal Cancer, Business Wire, April 20, 2010 [FriendFeed entry]. One of these is Poster #4293: Evaluation of activated CD44 as a biological target in the eradication of breast cancer stem cells, by Vera J Evtimov and Tracey J Brown [Presentation Abstract]. The other is Poster #4278: HA-Irinotecan targeting of activated CD44 is an effective therapy for the eradication of putative colon cancer stem cells [Presentation Abstract].

Recommendation and review posted by Fredricko


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