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Autism intervention “normalizes” kids’ brain function in study

Posted: November 1, 2012 at 5:40 am

An early intervention therapy for children with autism has been shown in a study to show unprecedented benefits in the brains of young children who have an autism spectrum disorder.

The study found the therapy, called the Early Start Denver Model (ESDM), not only boosted the cognition, language and social skills among very young children with autism but the researchers say it's the first study to show the intervention also "normalized" their brain activity.

"This may be the first demonstration that a behavioral intervention for autism is associated with changes in brain function as well as positive changes in behavior," Dr. Tom Insel, director of the National Institute of Mental Health, said in a press release.

About one in 88 children have an autism spectrum disorder, according to federal estimates. The disorders begin before age 3 and are characterized by persistent deficits in everyday social, communication and behavioral functioning.

With autism rates on rise, can early detection be stepped up? Here are 10 signs parents should check for in their infants

Some children may show hints of future problems within the first few months of life, while others may seem to develop normally until around 18 to 24 months of age and then stop gaining new skills or lose the skills they once had. Others may not show symptoms at all until 24 months of age.

The study was led by Dr. Geraldine Dawson, a professor of psychiatry at the University of North Carolina at Chapel Hill and Chief Science Officer of the advocacy organization, Autism Speaks. Researchers recruited a 48-participant study pool with children diagnosed with autism and typically-developing children who were between 18 and 30-months of age. There were three times more boys in the study; autism is almost five times more common among boys than girls.

About half the kids were assigned to receive ESDM for a two-year period while the other half were assigned to various community-based interventions in addition to other referrals, evaluations and reading materials. ESDM applies techniques of Applied Behavioral Analysis and other play-based, relationship-based teaching methods in 20 hours of weekly sessions.

After two years of interventions, the researchers measured the children's brain activity with EEG scans while they viewed pictures of faces -- to represent social cues -- and toys, to represent non-social cues. Earlier research shows children with autism have more brain activity viewing non-social cues, than faces -- the opposite effect of typically-developing children.

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Autism intervention "normalizes" kids' brain function in study

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Autism intervention "normalizes" kids' brain function in study

Posted: November 1, 2012 at 5:40 am

An early intervention therapy for children with autism has been shown in a study to show unprecedented benefits in the brains of young children who have an autism spectrum disorder.

The study found the therapy, called the Early Start Denver Model (ESDM), not only boosted the cognition, language and social skills among very young children with autism but the researchers say it's the first study to show the intervention also "normalized" their brain activity.

"This may be the first demonstration that a behavioral intervention for autism is associated with changes in brain function as well as positive changes in behavior," Dr. Tom Insel, director of the National Institute of Mental Health, said in a press release.

About one in 88 children have an autism spectrum disorder, according to federal estimates. The disorders begin before age 3 and are characterized by persistent deficits in everyday social, communication and behavioral functioning.

With autism rates on rise, can early detection be stepped up? Here are 10 signs parents should check for in their infants

Some children may show hints of future problems within the first few months of life, while others may seem to develop normally until around 18 to 24 months of age and then stop gaining new skills or lose the skills they once had. Others may not show symptoms at all until 24 months of age.

The study was led by Dr. Geraldine Dawson, a professor of psychiatry at the University of North Carolina at Chapel Hill and Chief Science Officer of the advocacy organization, Autism Speaks. Researchers recruited a 48-participant study pool with children diagnosed with autism and typically-developing children who were between 18 and 30-months of age. There were three times more boys in the study; autism is almost five times more common among boys than girls.

About half the kids were assigned to receive ESDM for a two-year period while the other half were assigned to various community-based interventions in addition to other referrals, evaluations and reading materials. ESDM applies techniques of Applied Behavioral Analysis and other play-based, relationship-based teaching methods in 20 hours of weekly sessions.

After two years of interventions, the researchers measured the children's brain activity with EEG scans while they viewed pictures of faces -- to represent social cues -- and toys, to represent non-social cues. Earlier research shows children with autism have more brain activity viewing non-social cues, than faces -- the opposite effect of typically-developing children.

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Autism intervention "normalizes" kids' brain function in study

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Changing brains of kids with autism

Posted: November 1, 2012 at 5:40 am

An intervention program called "Early Start Denver Model" emphasizes play therapy for very young children with autism.

STORY HIGHLIGHTS

(CNN) -- As the number of children with autism has risen dramatically over the past couple of decades, experts have learned that the earlier a child gets diagnosed, the earlier specialized therapy can be initiated, which can significantly improve outcomes.

Now researchers have been able to show that a particular type of behavioral therapy called the Early Start Denver Model (ESDM) not only improves autism symptoms, but actually normalizes brain activity and improves social behavior.

Autism is a neurodevelopmental disorder that starts to become very apparent around age 3. The main signs and symptoms of autism involve communication, social interactions and repetitive behaviors. According to the latest statistics from the U.S. Centers for Disease Control and Prevention, one in 88 children currently is diagnosed with autism, including one in 54 boys.

"Early intervention alters the trajectory of the brain and social development in children with autism," says Geraldine Dawson, the lead study author who developed the ESDM therapy along with study co-author Sally Rogers.

Twins Jacob and Lucas Campbell hooked up to EEGs.

Dawson was a researcher at the University of Washington when she helped devise ESDM; she's now the chief science officer for the advocacy and research group Autism Speaks and a professor at the University of North Carolina. Rogers is a professor and researcher at the University of California Davis MIND Institute.

ESDM therapy uses teaching methods from ABA ,or applied behavioral analysis, the traditional one-on-one interaction between a child and the therapist.

But rather than sitting at a desk next to the child -- where a teacher or therapist breaks down complex tasks into small components and gives tangible reinforcements -- children receiving ESDM are sitting on the floor, playing with their therapist or parents.

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Changing brains of kids with autism

Recommendation and review posted by Fredricko

Early therapy can change brains of kids with autism

Posted: November 1, 2012 at 5:40 am

An intervention program called "Early Start Denver Model" emphasizes play therapy for very young children with autism.

STORY HIGHLIGHTS

(CNN) -- As the number of children with autism has risen dramatically over the past couple of decades, experts have learned that the earlier a child gets diagnosed, the earlier specialized therapy can be initiated, which can significantly improve outcomes.

Now researchers have been able to show that a particular type of behavioral therapy called the Early Start Denver Model (ESDM) not only improves autism symptoms, but actually normalizes brain activity and improves social behavior.

Autism is a neurodevelopmental disorder that starts to become very apparent around age 3. The main signs and symptoms of autism involve communication, social interactions and repetitive behaviors. According to the latest statistics from the U.S. Centers for Disease Control and Prevention, one in 88 children currently is diagnosed with autism, including one in 54 boys.

"Early intervention alters the trajectory of the brain and social development in children with autism," says Geraldine Dawson, the lead study author who developed the ESDM therapy along with study co-author Sally Rogers.

Twins Jacob and Lucas Campbell hooked up to EEGs.

Dawson was a researcher at the University of Washington when she helped devise ESDM; she's now the chief science officer for the advocacy and research group Autism Speaks and a professor at the University of North Carolina. Rogers is a professor and researcher at the University of California Davis MIND Institute.

ESDM therapy uses teaching methods from ABA ,or applied behavioral analysis, the traditional one-on-one interaction between a child and the therapist.

But rather than sitting at a desk next to the child -- where a teacher or therapist breaks down complex tasks into small components and gives tangible reinforcements -- children receiving ESDM are sitting on the floor, playing with their therapist or parents.

The rest is here:
Early therapy can change brains of kids with autism

Recommendation and review posted by Fredricko

Bone Marrow Stem Cells – Video

Posted: November 1, 2012 at 5:40 am


Bone Marrow Stem Cells
http://www.cellmedicine.comFrom:cellmedicineViews:16679 35ratingsTime:06:26More inNews Politics

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Bone Marrow Stem Cells - Video

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Microscopic packets of stem cell factors could be key to preventing lung disease in babies

Posted: November 1, 2012 at 5:40 am

ScienceDaily (Oct. 31, 2012) Researchers at Boston Children's Hospital have found that microscopic particles containing proteins and nucleic acids called exosomes could potentially protect the fragile lungs of premature babies from serious lung diseases and chronic lung injury caused by inflammation.

The findings explain earlier research suggesting that while transplanting a kind of stem cell called mesenchymal stem cells (MSCs) could help reduce lung injury and prevent inflammation in a mouse model, the fluid in which the cells were grown was more effective than the cells themselves.

The research team -- led by Stella Kourembanas, MD, and S. Alex Mitsialis, PhD, and spearheaded by led by Changjin Lee, PhD, all of the Division of Newborn Medicine at Boston Children's -- published their findings online on October 31 in the journal Circulation.

Premature babies often struggle to get enough oxygen into their underdeveloped lungs, resulting in hypoxia and the need for ventilator assistance to breathe. Their lungs are particularly susceptible to inflammation, which can lead to poor lung growth and chronic lung disease. Inflammation is also often associated with pulmonary hypertension (PH) -- dangerously high blood pressure in the pulmonary artery (the vessel that carries blood from the heart to the lungs), which can have both short- and long-term consequences.

"PH is a complex disease fueled by diverse, intertwined cellular and molecular pathways," according to Kourembanas, who chairs Boston Children's Newborn Medicine division. "We have treatments that improve symptoms but no cure, largely because of this complexity. We need to be able to target more than one pathway at a time."

In 2009, Kourembanas, Mitsialis and others showed that injection of MSCs could prevent PH and chronic lung injury in a newborn mouse model of the disease. The results were puzzling, though, because the team found that few of the injected stem cells actually engrafted within the lungs. They also found that they could achieve better results by injecting just conditioned media -- the fluid the cells had been grown in -- than by injecting the cells themselves.

"We knew, then, that the significant anti-inflammatory and protective effects we saw had to be caused by something released by the MSCs," Kourembanas explained. "The question was, what?"

To answer that question, the research team grew mouse MSCs in the laboratory and searched the conditioned media for any secreted factors. They came upon exosomes, which many cell types, including MSCs, produce and release as a kind of communication vehicle.

The team found that injecting just purified exosomes from MSCs reduced lung inflammation and prevented the occurrence of PH in their animal model of PH. In contrast, neither MSC-conditioned media depleted of exosomes nor exosomes purified from other cell types had any effect on inflammation or PH in the model, indicating that something unique to the MSC-produced exosomes is required for their protective effect.

"We are actively working to figure out what exactly within the MSC-produced exosomes causes these anti-inflammatory and protective effects," Kourembanas said. "But we know that these exosomes contain microRNAs as well as other nucleic acids. They also induce expression of specific microRNAs in the recipient lung."

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Microscopic packets of stem cell factors could be key to preventing lung disease in babies

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