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Texas Flap Looms Over California Stem Cell Agency’s Grant Appeals

Posted: November 21, 2012 at 2:03 pm


In nine days, the California stem cell
agency plans to take another crack at finding ways to curb its
free-wheeling appeal process involving scientists whose applications
for millions have been rejected by reviewers.

It is a matter of considerable interest
to researchers who need the cash to keep their labs running and remain in good standing with their host institutions.
The stem cell agency's governing board this fall created a task force to deal with the appeals issue after a
record-breaking number of researchers made public appeals featuring
emotional patient advocates. Even the former chairman of the agency,
Robert Klein
, made a two-time pitch for one applicant. Board members
later complained publicly about “arm-twisting,” lobbying and“emotionally charged presentations.”
The agenda for the Nov. 30 task force
meeting in Oakland -- with teleconferencing sites in San Francisco,
Irvine, Palo Alto, Seattle and Rochester, N.Y. -- contains few clues
on what the panel is hoping to specifically accomplish in next week's
90-minute session.
But interested researchers can check
the transcript from the Oct. 24 meeting, during which CIRM President
Alan Trounson described the problem as “very critical.” He said,

“I think this is a very serious
matter that could really bite us very hard in a similar way to what's
happened in Texas. Unless we come up with some kind of process that
really addresses the science, it's a very large concern.”

Trounson's Texas reference was to the
mass resignations of reviewers at that state's $3 billion cancer
research effort. Questions have been raised about integrity of its grant review process and the program's political and biotech industry
relationships. James Drew of the Dallas Morning News produced a bit of an overview this week. In another piece, Eric Berger of the
Houston Chronicle provided quotes from emails from the infighting on
a controversial $18 million grant.
Changes in California's grant appeal process may well
be also discussed at the agency's board meeting Dec. 12 in Los Angeles.
The board hopes to wrap up its action by late January.
Here is a link to an item with more specifics on material presented to the task force in October. Here is a link to an August 2012 list of articles and documents related to the CIRM appeals process.
Interested parties can address comments
to the agency at info@cirm.ca.gov.   

Source:
http://feedproxy.google.com/~r/blogspot/uqpFc/~3/5vUXCLMoJz8/texas-flaps-looms-over-california-stem.html

Recommendation and review posted by G. Smith

Chemistry in its element – vinegar

Posted: November 21, 2012 at 11:39 am

It’s the kitchen acid everyone knows and loves. Find out about the hundreds of uses of vinegar – and the chemistry behind them - in this week’s Chemistry in its element

Digg This  Reddit This  Stumble Now!  Share on Facebook  Bookmark this on Delicious  Share on LinkedIn  Bookmark this on Technorati  Post on Twitter  Google Buzz (aka. Google Reader)  

Source:
http://prospect.rsc.org/blogs/cw/2012/11/21/chemistry-in-its-element-vinegar/

Recommendation and review posted by G. Smith

Methane production by treating vinasses from hydrous ethanol using a modified UASB reactor

Posted: November 21, 2012 at 12:00 am

Background:
A modified laboratory-scale upflow anaerobic sludge blanket (UASB) reactor was used to obtain methane by treating hydrous ethanol vinasse. Vinasses or stillage are waste materials with high organic loads, and a complex composition resulting from the process of alcohol distillation. They must initially be treated with anaerobic processes due to their high organic loads. Vinasses can be considered multipurpose waste for energy recovery and once treated they can be used in agriculture without the risk of polluting soil, underground water or crops. In this sense, treatment of vinasse combines the elimination of organic waste with the formation of methane. Biogas is considered as a promising renewable energy source. The aim of this study was to determine the optimum organic loading rate for operating a modified UASB reactor to treat vinasse generated in the production of hydrous ethanol from sugar cane molasses.
Results:
The study showed that chemical oxygen demand (COD) removal efficiency was 69% at an optimum organic loading rate (OLR) of 17.05 kg COD/m3-day, achieving a methane yield of 0.263 m3/kg CODadded and a biogas methane content of 84%. During this stage, effluent characterization presented lower values than the vinasse, except for potassium, sulfide and ammonia nitrogen. On the other hand, primers used to amplify the 16S-rDNA genes for the domains Archaea and Bacteria showed the presence of microorganisms which favor methane production at the optimum organic loading rate.
Conclusions:
The modified UASB reactor proposed in this study provided a successful treatment of the vinasse obtained from hydrous ethanol production.Methanogen groups (Methanobacteriales and Methanosarcinales) detected by PCR during operational optimum OLR of the modified UASB reactor, favored methane production.Source:
http://www.biotechnologyforbiofuels.com/content/5/1/82

Recommendation and review posted by G. Smith

Pomeroy Moving On, Will Leave Stem Cell Board

Posted: November 20, 2012 at 11:13 pm


Claire Pomeroy, one of the longtime
members of the governing board of the $3 billion California stem cell agency,
will be leaving her position at UC Davis and the stem cell board next
June.

Pomeroy yesterday announced her departure from Davis as vice chancellor for human health services and
dean of the medical school. In a telephone interview, she told the
California Stem Cell Report that she is examining a “few select
opportunities” to work at a national level on health reform and
health policy issues.
Claire Pomeroy
UC Davis photo
Pomeroy, 57, will be spending time in
Washington, D.C., working on health issues on behalf of the
University of California during the transition period before she
leaves her position in California.
Pomeroy came to UC Davis 10 years ago,
shortly before the Golden State's stem cell agency was created in
2004. At that time, UC Davis had what she called a “fledgling”
stem cell research effort. Today the school has chalked up $128 million in
grants from the stem cell agency, ranking fifth among institutions
funded by the agency.
She said that creation of the stem cell
agency “catalyzed development of our program,” which she said has
risen to “national prominence.”
Pomeroy's service on the stem cell
agency board was also instrumental in attracting a $100 million grant
from the Moore Foundation to start a new school of nursing at UC
Davis in 2009. Through her service on the board, she met Ed Penhoet,
who also served on the board and was one of the co-founders of Chiron
and then president of the Moore Foundation. Subsequently, Penhoet
called her for lunch to discuss her thoughts on nursing education,
and developments moved on from there.
The $100 million commitment was the
nation's largest grant for nursing education, according to the Moore Foundation.

Source:
http://feedproxy.google.com/~r/blogspot/uqpFc/~3/aS-PH9NtXbA/pomeroy-moving-on-will-leave-stem-cell.html

Recommendation and review posted by G. Smith

Conquering Chemical Sensitivity (MCS) and Healing Naturally

Posted: November 20, 2012 at 8:07 pm

Multiple chemical sensitivity (MCS) is a chronic condition in which an individual is highly sensitive to chemicals that are normally tolerated by other people. MCS is also known as environmental illness, sick building syndrome, chemical intolerance, toxin-induced loss of tolerance, reactive airway dysfunction and even Persian Gulf War Syndrome.

There is a wide variety of symptoms in MCS. These include:

· Fatigue
· Headache
· Insomnia
· Irritability
· Depression
· Memory loss
· Nausea

The precise cause of MCS is not known, though a few theories are being investigated. There is a controversy surrounding these theories however. Some believe that MCS is a purely psychological illness. Some like to call MCS sufferers hypochondriacs. They do this because of the many symptoms and chemical triggers of the illness. The truth is, MCS is difficult to study. But some researchers are making headway. The biological mechanisms underlying multiple chemical sensitivity are slowly being uncovered and are disproving the idea that MCS is a mental illness. These theories include:

· Oxidative stress
· Imbalanced immunity
· Central sensitivity
· Inflammation
· Limbic system dysfunction

Oxidative stress can explain both the initial triggering of MCS as well as the chronic persistence of the illness. A particular oxidative stress cycle in the body, known as the nitrous oxide/peroxynitrite cycle, is activated by a wide variety of chemicals. Each chemical activation worsens the cycle which then becomes difficult to stop. A chemical trigger or triggers initiates the cycle, and subsequent chemical contact, even at very low exposure, perpetrates the cycle, promoting the chronic nature of the illness.

Interestingly, this nitrous oxide/peroxynitrite cycle is also found in illnesses including chronic fatigue syndrome, fibromyalgia, and post traumatic stress disorder.

Nerve inflammation is another finding in people with MCS. This is thought to occur by the irritation of nerve endings in the upper airways from inhaled chemicals. This inflammation can manifest in other areas of the body causing the wide array of symptoms seen in MCS, specifically headache, myalgia (aches), arthritis and airway symptoms.

One theory of MCS states that inhaled chemicals enter the nostrils and affect the limbic system of the brain. The limbic system regulates mood and emotions, formation of new memories, fear, rage, aggression, pleasure, and reproductive cycles – all related to the symptoms of MCS.

The hypersensitivity seen in MCS could be due to some underlying factors. These factors are also found in other health conditions that are similar to MCS such as chronic fatigue syndrome and fibromyalgia. These underlying health conditions, when not treated, can contribute to the worsening of MCS. These factors include:

· Dysbiosis
· Candida overgrowth
· Leaky gut
· Food allergies and sensitivity
· Liver dysfunction

Dysbiosis is an imbalance in the ration of good to bad bacteria, or microbes, in the gut. Fungal dysbiosis can also occur, which usually involves an overgrowth of Candida. This increase in pathogenic bacteria and/or Candida results in the production of toxins and inflammation which causes the small intestine to become permeable, or leaky - a condition called leaky gut.

A leaky gut allows toxins to enter into the body. These toxins travel throughout the bloodstream and provoke an inflammatory response in various areas of the body. This can influence the symptoms that are experienced in MCS.

Toxic load is another term that is used in reference to MCS. Toxic load is the amount of toxins that the body can effectively handle and detoxify. This amount is different for everyone. In people with MCS, toxic load is very low. The body simply cannot tolerate toxins of any sort. Liver dysfunction may cause a slower detoxification process, also known as sluggish liver, resulting in an overburden of toxins. Leaky gut contributes to this overburden by sending toxins to the liver that would otherwise remain in the intestines and pass with bowel movements.

Standard Medical Treatment

There are varying treatments for MCS. All agree on one thing – avoidance of chemical triggers is important. From there, treatment varies. Some conventional doctors will dismiss the illness saying that it is “all in your head”. Antidepressant medications, usually selective serotonin reuptake inhibitors (SSRIs), are often prescribed by these doctors.

Treatment Alternatives

People with multiple chemical sensitivity need to be careful to take things slowly while healing. The first step is to regulate bowel elimination. Two to three bowel movements a day need to be occurring before detox and cleansing begins. This ensures that the body is able to regularly release toxins with the bowel movement. Then, a mild Total Body Cleanse, taken at half strength, followed by daily support of the liver with a liver supporting supplement, is recommended.

[Brenda Watson, C.N.C., is a New York Times bestselling author, PBS health educator and digestive care expert, and is considered one of the foremost authorities today on natural digestive health and the gut connection to total-body health. ]

Recommendation and review posted by G. Smith

HALF-LIFE 2 Episode 1 – [ part 9 ] – Screenshot Buddy! – Video

Posted: November 20, 2012 at 5:45 pm


HALF-LIFE 2 Episode 1 - [ part 9 ] - Screenshot Buddy!
Part 9 - With Edfake and Smiley_Pirate Mod used: Synergy Music; Edfake Game Info: Half-Life 2: Episode One is a first-person shooter video game, the first in a series of episodes that serve as the sequel for the 2004 Half-Life 2. It was developed by Valve Corporation and released on June 1, 2006. Originally called Half-Life 2: Aftermath, the game was later renamed to Episode One after Valve became confident in using an episodic structure for the game. Similar to Half-Life 2, Episode One also uses the Source game engine. The game debuted new lighting and animation technologies, as well as AI sidekick enhancements. The game #39;s events take place immediately after those in Half-Life 2, in and around war-torn City 17. Episode One follows scientist Gordon Freeman and his companion Alyx Vance as they fight in humanity #39;s continuing struggle against the transhuman race known as the Combine.From:EdfakeGamesViews:3 0ratingsTime:15:07More inGaming

Read more:
HALF-LIFE 2 Episode 1 - [ part 9 ] - Screenshot Buddy! - Video

Recommendation and review posted by G. Smith


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