Category Archives: Longevity Medicine

Now,he has some additional recommendations on what to eat, and these two may surprise you: oat (milk) and beer.

Okay, so Bland takes his oats in the warm bowlful topped with cinnamon or berries. But there's nothing wrong with the frothy espresso-topped kind, either.

"Oats have a lot of beta-glucan, which is a really important modulator of your microbiome," he says. That's right, eating or drinking your oats may help keep your gut healthy. Oats are also rich in vitamin E, phytic acid, and certain antioxidants that may help to reduce inflammation in the body.

Quarantine or not, having a beer now and then can take the edge off. But it may have more benefits than just a buzz. And when it comes to beer, the hoppier, the better.

"Beer has hops in it,"Bland says. "Hops are not only a bittering agent, but they are a bioactive member of the phytochemical families that stimulate insulin sensitivity and cause lipid metabolism."

Hops has been revered for its ability to help you sleep. You can get hops extract on its own if you don't want the buzz (or calories) of beer. Consuming hops has also been linked to reducing the risks ofmetabolic syndrome.

But don't just grab any old beer. Go for something that's extra hoppy, says Bland.

"Go for an IPA, because you have more of those isoflavones and humulones from the hops." And don't overdo it. "Just as with wine or with tequila, it has to do with magnitude," he says.

No surprise that the father of functional medicine recommends balance.

Excerpt from:
The Father of Functional Medicine Says Drink Oat Milk and Beer - The Beet

D. DowdMuska

By D. DowdMuska

COVID-19 is real, and it is vicious. It has killedtens of thousands of Americans. More will follow.

But the disease isnt acting alone. It has some unlikely co-conspirators. Millions, in fact.

Dig into the grim statistics documenting deaths linked to the novel coronavirus and youll quickly grasp the significant contribution made bycomorbidity. No data illustrate the problem better thanthose compiled in the New York City hot zone. As of this writing, 73.6 percent of the Big Apples COVID-19 victims have been senior citizens. But 79.1 percent of those killed of any age suffered from underlying conditions, such as diabetes, cancer, hypertension and obesity. Pre-existing health woes afflicted 79.2 percent of victims between 18 and 24, but 84.7 percent of those killed between 25 and 64.

Two decades into the 21st century, the United States was ripe, so to speak, for quite a lot of coronavirus carnage. Because in spite of the incessant scolding of politicians, bureaucrats and activist organizations, were a nation simply unwilling to look after our health.

In 2005, Michigan States Mathew J. ReevesdocumentedAmericans unbridled self-destructiveness. The epidemiologist looked at our countrymens commitment to four health habits: regular exercise, eschewing cigarettes, consuming fruits and vegetables daily, and maintaining a respectable body mass index.

The share of the population that practiced all four behaviors? Three percent.

Reeves called his findings pretty remarkable, noting that eating right, moving muscles, and avoiding coffin nails is really just a basic lifestyle pattern. We arent asking anyone to climb Mount Everest here.

A decade and a half later, not much has changed. Thesmoking ratehas dropped.But obesity has gotten worse.According toa 2017 analysisby the Centers for Disease Control and Prevention, Very few Americans eat the recommended amount of fruits and vegetables every day, putting them at risk for chronic diseases like diabetes and heart disease. Andexercise remains anathema to a huge share of the populace.

The refusal to embrace clean living has an incontrovertible effect. In 2013, the National Research Council and Institute of Medicine cobbled together the scary consequences of rejecting Reeves basic lifestyle pattern. The405-page study U.S. Health in International Perspective: Shorter Lives, Poorer Healthfound that though life expectancy and survival rates in the United States have improved dramatically over the past century, Americans live shorter lives and experience more injuries and illnesses than people in other high-income countries.

When judged against the average of 16 peers, a list that included Germany, Australia, Japan, Norway and Canada, the United States fared worse in nine health domains, including heart disease, substance abuse and adverse birth outcomes.

On top of exposing a soft underbelly to COVID-19, Americans unhealthiness is astronomically expensive. If you are unaware of the historical numbers, its best to sit down. Here is U.S. spending on health care consumption, per capita, adjusted to 2018 dollars:

1960 $1,132

1970 $2,072

1980 $3,114

1990 $5,154

2000 $6,665

2010 $9,170

The 2018 bill: $10,638. So during those nearly six decades, spending rose by a factor of 9.4.

Inevitable, due to an aging population? Enhanced longevity doubtless contributed, but consider what was learned about health-promoting behaviors during the period e.g., the sine qua non ofsocial interaction, thevalue of exercise, the need foradequate sleep, thebenefits of pet ownership, theadvantages of prayer/meditation, the boost froma bath in nature. In addition, the federal governments catastrophically wrong dietary guidelines (fat bad, carbs good) were thoroughly debunked.

Yet while knowledge grew about how to calm the mind, strengthen the immune system, reduce pain/inflammation and improve energy, health habits became increasingly injurious. Entirely by choice. Phillip Longman is one of the few researchers who understands thatthe reason we dont live any longer than Costa Ricans is differences in behavior.

Americans, the demographer wrote, exercise less, eat more, drive more, smoke more and lead more socially isolated lives. Even at its best, modern medicine can do little to promote productive aging, because by the time most people come in contact with it their bodies are already compromised.

Aspolicy experts Kenneth Thorpe and Jonathan Lever explained: Largely preventable and highly manageable chronic diseases account for 75 cents of every dollar we spend on health care in the United States.

Cruelly opportunistic,SARS-CoV-2is targeting the substantial number of Americans who couldnt be bothered with a nutrient-dense diet, spent far too many hours on the couch, and stuck with their smokes. When this pandemic is over, it will be time for an overdue discussion of health care and personal responsibility.

Excerpt from:
COVID-19 and American health choices - The Advocate-Messenger - Danville Advocate

SINGAPORE,May 14, 2020/PRNewswire/ Duke-NUS Medical School (Duke-NUS), a research intensive graduate-entry medical school, GenScript Biotech Corporation (GenScript, Stock Code: 1548.HK), a leading global biotechnology company, and the Diagnostics Development Hub (DxD) atSingaporesAgency for Science, Technology and Research (A*STAR), today announced an exclusive agreement to co-develop and manufacture a unique serological coronavirus (COVID-19) detection system known as the surrogate virus neutralisation test (sVNT) or cPass. This test is the first in the world that allows rapid detection of neutralising antibodies (NAbs) the specific antibodies present in the serum of COVID-19 patients that are responsible for clearing the viral infection, without the need of live biological materials and biocontainment facility.

While there are many COVID-19 lab-based antibody test kits commercially available, this is the first that is capable of measuring functional NAbs. Without a simple test kit, measuring NAbs requires the use of live virus, cells, highly skilled operators, and complex laboratory procedures that are generally less sensitive and require several days to obtain results. By contrast, the cPass can be rapidly conducted within an hour in most research or clinical labs, and is also amenable to high throughput and fully automated testing after minimal adaptation. This test will also help in current COVID-19 investigations, from contact tracing to determining infection rates, herd immunity and predicted humoral protection.

Professor Wang Linfa, DirectorofDuke-NUS Emerging Infectious Diseases programme, and team conceived this research and invented the cPassdiagnostic test. The team also did the assay development and testing inSingapore.

GenScript went through the steps of proof concept research, product design, development and optimisation, and now plays a central role in the commercialisation process, using its global network and manufacturing capacity to launch cPass inSingaporeand other regions around the world.

DxD Hub is a national initiative led by A*STARs commercialisation arm, A*ccelerate. To take this sVNT to market, DxD Hub validated the kit with clinical samples, and developed the manufacturing protocol and quality controls to secure its provisional authorisation by the Health Sciences Authority. DxD Hub will also be producing the pilot batch for use inSingaporehospitals. There are plans for this know-how to be transferred to local biotech companies for scaled-up production.

The cPass developed by our team can be used for contact tracing, reservoir or intermediate animal tracking, assessment of herd immunity, longevity of protective immunity and efficacy of different vaccine candidates. It does not require a biosafety containment facility, which makes it immediately accessible to the global community, including many developing nations, said Professor Wang Linfa, the principal investigator of this collaboration. One of the most internationally recognised experts on emerging zoonotic viruses, he currently serves on multiple World Health Organisation committees focusing on COVID-19.

Duke-NUS is excited to partner with GenScript as well as DxD Hub to address the challenge of COVID-19 serology with this novel detection system. This could be a game changer in the field of COVID-19 investigation, saidProfessor Patrick Casey, Senior Vice Dean of Research at Duke-NUS.

This innovative platform developed by our researchers will be extremely useful for quick and reliable surveillance to determine how widely a population has gained immunity to SARS-CoV-2 virus. The partnership with GenScript and DxD Hub combines complementary strengths as we work together to fight this global outbreak, said ProfessorThomas M. Coffman, Dean of Duke-NUS.

Dr ZhuLi, Chief Strategy Officer of GenScriptadded, The serological detection system developed by Prof Wang is unique, innovative, and has many advantages, such as high sensitivity and specificity, and applicability to all antibody isotypes.The test results will be of great help to governments in guiding the resumption of work since it is extremely useful for quick and reliable surveillance to determine how widely a population has gained immunity to SARS-CoV-2 virus. Detection of neutralising antibodies determines who can more safely go back to work or to more social life. Our partnership with Duke-NUS and DxD Hub is one of several proactive steps we are taking to strengthen our R&D and manufacturing capacity to meet this urgent global need.

Recently, GenScript has started to serveSingaporemarket by utilising our internal sales organisation along with other commercial functions for market access, marketing and distribution. We are excited to be part of the thriving culture of innovation across laboratories in the Asia Pacific Region. Our partnership aims to make the best use of our mutual capabilities, expertise, and resources, which helps us to serve our community better, saidJohnson Wang, President in Asia Pacific Region at GenScript.

Sherry Shao, President of Life Science Group at GenScript echoed, The collaboration with Duke-NUS is a key example of how global industry and academia work together to make things happen. Leveraging the leading technologies in molecular biology, protein science and immunology, we help our partners in virus mapping, detection, treatment and vaccine development. GenScript is committed to fighting the pandemic with the world.

DrSidney Yee, CEO of DxD Hub said: As Singapores national platform that provides end-to-end expertise in bringing diagnostic kits from bench to bedside, DxD Hub is proud to be part of this collaboration with Duke-NUS and GenScript. This innovative cPass diagnostic kit will be instrumental in supporting the fight against the global pandemic.

The cPass assay was validated with samples of patients from PROTECT- A Multi-centred Prospective Study to Detect Novel Pathogens and Characterise Emerging Infections, coordinated bySingaporesNational Centre for Infectious Diseases.

About Duke-NUS Medical School

Duke-NUS isSingaporesflagship graduate entry medical school, established in 2005 with a strategic, government-led partnership between two world-class institutions:Duke UniversitySchool of Medicine and theNational University of Singapore(NUS). Through an innovative curriculum, students at Duke-NUS are nurtured to become multi-faceted Clinicians Plus poised to steer the healthcare and biomedical ecosystem inSingaporeand beyond. A leader in ground-breaking research and translational innovation, Duke-NUS has gained international renown through its five signature research programmes and eight centres. The enduring impact of its discoveries is amplified by its successful Academic Medicine partnership with Singapore Health Services (SingHealth),Singaporeslargest healthcare group. This strategic alliance has spawned 15 Academic Clinical Programmes, which harness multi-disciplinary research and education to transform medicine and improve lives.

For more information, please visitwww.duke-nus.edu.sg.

About GenScript Biotech Corporation

GenScript Biotech Corporation (Stock Code: 1548.HK) is a global biotechnology group. Based on its leading gene synthesis technology, GenScript has developed four major platforms including the global cell therapy platform, the biologics contract development and manufacturing organisation (CDMO) platform, the contract research organisation (CRO) platform and the industrial synthesis product platform.

GenScript was founded inNew Jersey, US in 2002 and listed on the Hong Kong Stock Exchange in 2015. GenScripts business operation spans over 100 countries and regions worldwide with legal entities located in the US, Mainland China,Hong Kong,Japan,Singapore,NetherlandsandIreland. GenScript has provided premium, convenient, and reliable products and services for over 100,000 customers.

GenScript has a number of intellectual property rights and technical secrets, including more than 100 patents and over 270 patent applications. As ofDecember 31, 2019, GenScripts products and services have been cited by 42,200 peer-reviewed journal articles worldwide.

For more information visitwww.genscript.com.

About the Agency for Science, Technology and Research (A*STAR)

The Agency for Science, Technology and Research (A*STAR) isSingaporeslead public sector R&D agency, spearheading economic-oriented research to advance scientific discovery and develop innovative technology. Through open innovation, we collaborate with our partners in both the public and private sectors to benefit society.As a Science and Technology Organisation, A*STAR bridges the gap between academia and industry. Our research creates economic growth and jobs forSingapore, and enhances lives by contributing to societal benefits such as improving outcomes in healthcare, urban living, and sustainability. We play a key role in nurturing and developing a diversity of talent and leaders in our Agency and research entities, the wider research community and industry. A*STARs R&D activities span biomedical sciences and physical sciences and engineering, with research entities primarily located in Biopolis and Fusionopolis. For ongoing news, visitwww.a-star.edu.sg.

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For media enquiries, please contact:

Lekshmy Sreekumar, Ph.D.CommunicationsDuke-NUS Medical SchoolTel: +65 65161138Email:lekshmy_sreekumar@duke-nus.edu.sg

Aloe XueCommunicationsGenScript Biotech CorporationTel: +10 (25) 5889 7288 ext. 6318Email:aloe.xue@genscript.com

MsLynn HongA*STAR Corporate CommunicationsTel: +65 9764 0438hongxl@hq.a-star.edu.sg

For commercial enquiries, please contact:GenScript DiagnosticsTel: +1 (732) 317-5055Email:CovidKits@genscript.com

SOURCE GenScript Biotech Corporation

http://www.genscript.com

Source: https://www.prnewswire.com/news-releases/duke-nus-genscript-and-astar-launch-first-in-the-world-sars-cov-2-serology-test-to-detect-neutralising-antibodies-without-need-of-containment-facility-or-specimen-301059964.html

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Duke-NUS, GenScript and A*STAR launch first-in-the-world SARS-CoV-2 serology test to detect neutralising antibodies without need of containment...

The Precision Medicine Software market report focuses on the COVID-19 Outbreak Impact analysis of key points influencing the growth of the market. The intelligence report prepared contains details on the leading players of the global market, along with various depending aspects related and associated with the market. Profile the Top Key Players, with sales, revenue and global market shares are analyzed emphatically by landscape contrast and speak to info. Upstream raw materials and instrumentation and downstream demand analysis is additionally administrated.

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Global Precision Medicine Software Market To Witness The Highest Growth Globally In Coming Years 2020-2026 - Cole of Duty

FLINT, Mich. A baby born in Flint, where I am a pediatrician, is likely to live almost 20 fewer years than a child born elsewhere in the same county. Shes a baby like any other, with wide eyes, a growing brain and a vast, bottomless innocence too innocent to understand the injustices that without her knowing or choosing have put her at risk.

Some of the babies I care for have the bad luck to be born into neighborhoods where life expectancy is just over 64 years. Only a few miles away, in a more-affluent community, the average life span is 84 years. The ravages of Covid-19, which disproportionately affect low-income families and people of color, are surely widening this gap even further.

Throughout the United States, geography defines and describes inequities in health, wealth, mobility and longevity. The reasons for this are both visible and hidden. Life in a distressed neighborhood means limited access to health care and healthy food. It means living with violence, racism, poverty and uncertainty. It means bearing the brunt of environmental injustice not having safe and affordable water, as Flint knows too well, or living in the shadow of a polluting factory. More air pollution increases rates of respiratory disease and reduces student achievement as well as life span. We are also beginning to understand the interplay of water access and air quality with Covid-19 severity.

These disparities between neighborhoods are rarely accidental; they are the product of purposeful policies and practices that have widened gaps in income, opportunity and equality. Over the decades, city inhabitants have been battered by deindustrialization; racist banking and real estate practices; white flight and population loss; austerity cuts to public education, public health and safety net programs; the corporate-driven weakening of unions; dilution of environmental regulations; housing and nutrition insecurity; and racially driven mass incarceration. And so much more.

Science tells us that children exposed to multiple adversities, both in their home and in their neighborhood, have a far greater likelihood of challenges later in life. From addiction to eviction, these constant pressures change children on a molecular, cellular and behavioral level and make them sick. The effects of toxic stress can be as disruptive as environmental pollution on their bodies and brains, increasing risk for chronic diseases like asthma and hypertension, and lowering life expectancy. Exposure to six or more adverse childhood experiences can cut a life short by as much as 20 years.

The pandemic hot spots in Michigan follow this pattern: Outside of metropolitan Detroit, the troubled Flint area has been hardest hit. In Flint, we just marked the sixth anniversary of the water crisis, when poisonous, lead-laced water was used to fill baby bottles and sippy cups of unsuspecting Flint kids who just happened to be born in the wrong city. Now were being ravaged by another preventable public health emergency. With over 200 deaths, the county where Flint is has more Covid-19 fatalities than 19 states to date.

All of us who live or work in this beleaguered community know somebody who has died from the disease caused by the coronavirus. Theres Wendell Quinn, the gentle giant of a hospital public safety officer who always gave me a warm smile and a nod when I walked into work; and Ruben Burks, the dedicated United Auto Workers leader; and Nathel Burtley, the first black superintendent of Flint schools; and Karen Dozier, the kind and loving custodian at the early child care center. And bringing a level of grief that is difficult to comprehend, Calvin Munerlyn, a Family Dollar store security guard and devoted father of six, was recently shot and killed after telling a shopper to wear a mask. The epidemic of gun violence has compounded tragedy upon tragedy.

At a multigenerational level of loss, there are the Jones and Brown families. Within weeks, a Flint elementary school principal, Kevelin B. Jones II, lost his father, Pastor Kevelin B. Jones; his uncle Freddie Brown Jr.; and his cousin Freddie Brown III. At the combined burial for her husband and only child, Sandy Brown waved to the parade of cars that drove by quietly as she stood alone next to two freshly dug graves. Reflecting on the difficult losses, a church elder, Keimba Knowlin, spoke on resilience, a quality that Ive long observed and admired in the people of Flint. Were going to rise above this and get past this, he said.

The will to survive and endure can be the deciding factor between a child who overcomes adversity and thrives and a child who never makes it to adulthood. But how long can we ask people born in the wrong ZIP code to rise above and persevere in circumstances beyond their control, no matter how central the idea of overcoming is to our archetypal American identity? When Hazim Hardeman, a 2019 Rhodes scholar, was asked about his journey from public housing in North Philadelphia, where many of his friends were shot or stabbed to death, he spoke a truth that we all need to hear: Dont be happy for me that I overcame these barriers. Be mad as hell that they exist in the first place.

Surviving lifes hardest blows should not be celebrated or expected. Recovery and reconciliation require reparations and resources. To expect resilience without justice is simply to indifferently accept the status quo.

Just as the New Deal sprang from the Great Depression and public health best practices were born in response to a previous plague, we need to embrace the bold innovations that are certain to arise.

To begin with, we need to establish policies and practices rooted in science. And science tells us that where you live matters. For children raised in places replete with the stresses of misfortune, these adversities rooted in historic and systemic bias are scarring. Just as new Covid-19 cases can represent a time lag from infection two weeks earlier, adversities in early childhood play out later, filling our hospital beds and deteriorating the publics health.

As this pandemic makes painfully visible, medicine alone ventilators, pharmaceuticals, defibrillators, I.C.U.s will not save us. Its always an ego-deflating moment for my medical residents when they learn that medical care contributes only 10 percent to 20 percent to positive health outcomes. Our medical interventions are largely reactive measures and happen too late. Addressing the upstream root causes is the only answer.

This means mandating universal basic income and living wages, for a start, and enhancing health and safety protections, along with benefits like paid parental and sick leave. This means establishing desegregated and well-funded public education, starting with child care, as a fundamental right. Universal health care needs to be untethered from employment and free of racial disparities. And environmental health regulations need to be strengthened and enforced so that all children no matter the ZIP code can breathe clean air and drink safe water.

These big and bold ideas are not new. They are measures proved to improve health, quality of life and longevity standards that most developed countries already employ. And to ensure we are moving in the same direction together, the pathogens of divisiveness and bigotry need to be treated as the deadly, life-shortening contagions they truly are.

This is how we begin to transform the concept of resilience from an individual trait to one that describes a community and society that cares for everyone. Rather than hoping a child is tough enough to endure the insurmountable, we must build resilient places healthier, safer, more nurturing and just where all children can thrive. This is where prevention and healing begin.

Mona Hanna-Attisha (@MonaHannaA) is a pediatrician and professor at Michigan State University College of Human Medicine in Flint. She is also the director of the Pediatric Public Health Initiative and author of What the Eyes Dont See: A Story of Crisis, Resistance, and Hope in an American City.

The Times is committed to publishing a diversity of letters to the editor. Wed like to hear what you think about this or any of our articles. Here are some tips. And heres our email: letters@nytimes.com.

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Illustration by Giacomo Bagnara

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Im Sick of Asking the Children of Flint to Be Resilient - The New York Times

What Maharishi Charaka the father of Ayurveda system of medicine mentioned 2000 years ago in Charak Samhita, Rasayana treatment is also an answer to epidemics, has now been turning out to be a reality. See, lately, the Ayush Ministry has approved to launch clinical research studies on the possibility of using Ayurvedic medicines as preventive or add-on to standard care to Covid-19.

This is a joint initiative of the Ministries of Ayush, Health, Science & Technology through the Council of Scientific and Industrial Research (CSIR) with technical support from the Indian Council of Medical Research (ICMR). They are going to work together to test four Ayurvedic formulations (Rasayanas) Ashwagandha, Yashtimadhu, Guduchi, Peepli and Ayush 64 for the purpose.

Ever since the outbreak of Covid-19 pandemic and the probable preventive measures being applied, Ayurveda finds an upper hand. Earlier, at the onset of the outbreak of the pandemic, our PM urged the people to follow the Ministry of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy (AYUSH) protocol on ways to stay fit and enhance immunity and make it a part of their lives. And these Ayurvedic measures are on the go and have been instrumental in boosting immunity, which is the most effective arsenal to combat this virus. And lately, the governments nod for clinical trials of Ayurvedic formulations (Rasayanas) will be an icing on the cake if it turns out to be effective against Covid-19.

Indeed, this is a welcome move by the Ayush Ministry to try a hand with Ayurvedic Rasayanas, which have the potential to come up with a probable preventive cure in some form or the other. The Rasayana products have the characteristics to increase or decrease some aspect of the bodily processes system to create balance. It can work in a multi-directional manner to help the bodily processes in regaining balance and maintaining it. The Rasayana has a vital impact on the immune system, which is the key to preventing much in terms of any illness. And it has been reported in Covid-19 cases that the stronger the immunity, the safer you are the weaker the immunity, the more vulnerable you are.

In case of Covid-19 infection Ayurvedic Rasayana can be helpful in all the three stages. In stage one it can very effectively prevent a person from getting infected by strengthening the immune system. In the stage two if someone has got infected, the only way he can come out of infection is due to his immunity and that is apparent from the available data, which shows despite the fact that there is no treatment for Covid-19 infection, more than 83% of closed cases, people get cured of infection. It is because of their own defence mechanism. It is quite logical that if the defence mechanism of an individual is strengthened with any effective Ayurvedic Rasayana he will come out of the infection faster and with much less damages as compared to just on his own. Third stage is post-Covid-19 infection when a person comes out of infection he comes out with some severe morbid conditions these can be improved with the help of some specific Ayurvedic Rasayana/medicines, because if ignored this could cause lifelong problems.

The Ayurvedic Rasayanas, in the form of single herbs except Ayush-64, which have recently got the nod for the trial by the government have almost all the characteristics to bring holistic health, strengthening immunity but our rich Ayurvedic heritage have a long list of Rasayanas having multiple herbs working in synergy to create much greater effect. The key to safeguard us from any infection is our own immunity or defence mechanism therefore it has to be strengthened as much as possible. Today it is Covid-19, tomorrow it could be something else, may be more deadly, may be less. But one thing is sure that new viruses will keep coming and we must keep ourselves prepared with strong immunity.

The role of Rasayana in restoring holistic health and fighting the infections borne by the epidemics is predominant. One of such Rasayana product is Maharishi Amrit Kalash well-known and well researched, with about 40 non-clinical and four clinical studies, conducted in renowned institutions around the world, to its credit. All indicating it to be successful for restoring health, longevity and overall balance and wellbeing. So, going natural and taking care of your health aiming for longevity and preparing the body to fight an infection like the current one, including the intake of the best and the most reliable Rasayana product Maharishi Amrit Kalash would be a wise option.

Read more here:
Ayurvedic Rasayanas to battle against upsurge of Covid-19 pandemic | FNB News - fnbnews.com