Category Archives: Longevity Medicine

Short bursts of physical exercise induce changes in the bodys levels of metabolites that correlate to an individuals cardiometabolic, cardiovascular, and long-term health, a study by Harvard-affiliated Massachusetts General Hospital (MGH) has found.

In a paper published inCirculation, the research team describes how about 12 minutes of acute cardiopulmonary exercise affected more than 80 percent of circulating metabolites, including pathways linked to a wide range of favorable health outcomes, thus identifying potential mechanisms that could contribute to a better understanding of cardiometabolic benefits of exercise.

What was striking to us was the effects a brief bout of exercise can have on the circulating levels of metabolites that govern such key bodily functions as insulin resistance, oxidative stress, vascular reactivity, inflammation, and longevity, said investigator Gregory Lewis, section head of Heart Failure at MGH and senior author of the study.

The MGH study drew on data from the Framingham Heart Study to measure the levels of 588 circulating metabolites before and immediately after 12 minutes of vigorous exercise in 411 middle-aged men and women.

The research team detected favorable shifts in a number of metabolites for which resting levels were previously shown to be associated with cardiometabolic disease. For example, glutamate, a key metabolite linked to heart disease, diabetes, and decreased longevity, fell by 29 percent. And DMGV, a metabolite associated with increased risk of diabetes and liver disease, dropped by 18 percent. The study further found that metabolic responses may be modulated by factors other than exercise, including a persons sex and body mass index, with obesity possibly conferring partial resistance to the benefits of exercise.

Intriguingly, our study found that different metabolites tracked with different physiologic responses to exercise, and might therefore provide unique signatures in the bloodstream that reveal if a person is physically fit, much the way current blood tests determine how well the kidney and liver are functioning, notes co-first author Matthew Nayor of the Heart Failure and Transplantation Section in the Division of Cardiology at MGH. Lower levels of DMGV, for example, could signify higher levels of fitness.

The Framingham Heart Study, which began in 1948 and now embraces three generations of participants, allowed MGH researchers to apply the same signatures used in the current study population to stored blood from earlier generations of participants. By studying the long-term effects of metabolic signatures of exercise responses, researchers were able to predict the future state of an individuals health, and how long they are likely to live.

Were starting to better understand the molecular underpinnings of how exercise affects the body and use that knowledge to understand the metabolic architecture around exercise response patterns, says co-first author Ravi Shah of the Heart Failure and Transplantation Section in the Division of Cardiology at MGH. This approach has the potential to target people who have high blood pressure or many other metabolic risk factors in response to exercise, and set them on a healthier trajectory early in their lives.

Lewis is associate professor of medicine at Harvard Medical School and director of the Cardiopulmonary Exercise Testing Laboratory at MGH. Nayor is a cardiologist at MGH and instructor of medicine at Harvard Medical School, and Shah is a cardiologist at MGH and assistant professor of medicine at Harvard Medical School. Other co-authors include Ramachandran Vasan, professor of medicine at Boston University and principal investigator of the Framingham Heart Study, and Clary Clish, senior director of Metabolomics at the Broad Institute of MIT and Harvard.

The study was supported by the American Heart Associations Grand Challenge Award and the National Institutes of Health.

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12-minute bursts of exercise have bigger impact than thought - Harvard Gazette

World War II veteran Frank Caruso, 99, and his wife, Ann, 94, at The Fountains assisted living facility in Tuckahoe looks on Nov. 2, 2020. Caruso will turn 100 years-old on Nov. 19. Rockland/Westchester Journal News

WHITE PLAINS, N.Y. Wednesdayis Veterans Day, when Americaremembers those who served in its armed forces.

Frank Caruso served in World War II. And this Veterans Day, just eight days shy of his 100th birthday, his memory still serves him remarkably well.

When asked for the secret to his longevity and happy life, he turns to Anna, his wife of 72 years.

"There she is," he said. "There's the secret."

Then Carusooffersanother suggestion.

"I have a longevity medicine," he said. "One Absolut vodka martini a day, just one, with a drop of Vermouth and no fruit."

Caruso's stories fly with flecks of tantalizing detail, from the shadow of Italy's Mount Vesuvius to "Mad Men"-era New York and beyond.

World War II veteran Frank Caruso, 99, with his wife Ann, 94, at The Fountains assisted living facility in Tuckahoe Nov. 2, 2020. The couple have been married for 72 years and Caruso will be a 100 years-old on Nov. 19.(Photo: Tania Savayan/The Journal News)

"I have to think, 'What era did I do that in?' because I sort of had separate different lives that I've lived through the years," Caruso said. "You try to remember them in groups."

Each "group" is well-represented as Caruso speaks, inching his wheelchair forward, a storyteller eager to be closer to his audience at a New York retirement home.

There were the early years in Detroit, before his tailor-father Michele Caruso, a native of Abruzzo, Italy, moved the family to the Bronx in 1929. Then came the Depression and his war years in the Army service that found him in Rome, shaking hands withPope Pius XII.

Cpl. Francis J. Caruso went from working at the Brooklyn Navy Yard in 1942 to 30 months in overseas service in U.S. Army in World War II, in North Africa, Italy and Corsica.(Photo: Submitted)

After the war came his wife, Anna, and their two children.

Caruso spent years as a commercial artist on New York City'sMadison Avenue. From 1956 to 1987, he worked in commercial packaging for American Can Company, in Midtown Manhattan and, later, Greenwich, Connecticut.

That he has lived 99 years and 51 weeks through war and, now pandemic is remarkable.The U.S. Department of Veterans Affairs estimates that fewer than 325,000 of the 16 million Americans who served in World War II are still alive.

He wears a mask out of deference to the coronavirus pandemic which has hit the elderly hardest, accounting for 171,814 deaths of those age65 or older, according to the Centers for Disease Control and Prevention.

When Caruso remembers his military service as an artillery instrument operator, siting shellsin Gen. Mark Clark's Fifth Army inNorth Africa and the invasion of Italyhis memories arepart battle objectives, part weather report.

"You listen to artillery shells all day long, back and forth," he said. "The Germans shelling, the Americans shelling all day."

Caruso moved onto Corsica and on toSalerno, as the Americans worked theirway up Italy's "boot." There was time spent in Naples, where, at night, he could see flames rising from a simmering Mount Vesuvius.

There was, by Caruso's account, all kinds of weather, conjuring images from Pulitzer Prize-winning cartoonist BillMauldin, whose workregularly depicted soggy GIs in flooded foxholes.

Caruso's basic training was on "bitter cold Cape Cod," followed by a landing in North Africa, "where it was 120 degrees in the shade."

Cpl. Francis J. Caruso lent his artistic talents to the war effort during the 30 months he spent overseas in World War II. Here's one of his creations, emblazoned on the side of a B-25 bomber(Photo: Submitted)

Caruso found time for one non-artillery assignment in Corsica while waiting for the storming of Italy: Knowing that Caruso was an artist, afriend volunteeredhimto decorate a B-25 bomber nicknamed Sahara Sue II.

Caruso remembered having to scour the airfield for paints and brushes before spendingtwo weeks or so to emblazon the plane with a leggy lady.

Last year, 76 years later, Caruso met aretired Air Force officer at New York's Westchester County Airport, where World War II-era aircraft were on display. Within hours of mentioning that long-ago painting assignment to the officer, "I came home and he flipped this onto my computer."

A photo of Sahara Sue II.

"He found this plane," Caruso said, his voice full of awe. "Of all the thousands of planes we had."

First-generation American and World War II veteran Frank Caruso, 99, talks about his life experiences Nov. 2, 2020 at The Fountains assisted living facility in Tuckahoe. Caruso will turn 100 years-old on Nov. 19.(Photo: Tania Savayan/The Journal News)

The Americans fought north from Salerno to Naples and onto another key objective: the monastery atop Monte Cassino.

Bombing was finally approved on Feb. 15, 1944.

"I remember that day very vividly, because it felt like every plane in Italy was in the air dropping bombs," Caruso recalled. "And after it was all through, the Germans still had it. It was so well guarded. They had to go up on foot, climb up the side of mountain on foot to take it eventually."

When the war in Europe ended, Caruso was in Pisa, within walking distance of the leaning tower. V-E Day in May 1945 wasn't a big blowout for GIs still in Italy, he recalled.

When a visitor expresses surprise that the end of the war in Europe didn't launch a huge party, Caruso offers a simple defense: "Well, they didn't have much good booze," he said. "They mostly had cordials."

There was another war, still raging in May 1945 when Germany surrendered.

"The big fear we all had was that when the war ended in Europe we were going to be shipped to Japan," he said. But the point system years of service overseas and combat service pins meant Caruso was sent home.He was discharged in November 1945.

When he returned to the Bronx, he had spent 30 months overseas.

"That was a pretty rough deal, I think, for anybody," he said. "Nobody could go home those days. They didn't have rotations."

After his war service, Frank Caruso earned an advertising degree from Pratt Institute and worked for a NYC advertising agency before landing a job at American Can Company in New York and, later, Greenwich. where he stayed for 31 years. Frank Caruso will mark his 100th birthday on Nov. 19, 2020.(Photo: Submitted)

Back in the Bronx, arelative introduced Caruso "to a school chum" of Anna Pace. Before long, he and Pace were dating. They married on Feb. 7, 1948.

He earned his Pratt Institute advertising design degree at night while working for a Manhattan ad agency, then he got a job in package design for American Can Company, where he stayed for 31 years, from 1956 to 1987.

His portfolio brims with designs for Fanta soda and Schlitz cans, including print ads that would find their way into glossy magazines and newspapers.

Duringthose Midtown "Mad Men" years,Carusodeveloped a cherished ritual that he said was one of his secrets to a long life: a single vodka martini a day.

It was a habit he developed on New York City's Madison Avenue. He said heloved working in Midtown in that post-war era, where lunches were regularly accompanied by a cocktail.

"Madison Avenue was known for its swingers and everything else, and for a long time, everybody drank Manhattans," he said. "But here's the secret: You drink aManhattan, you come back, they can smell you a half-a-mile away. You drink a vodka martini, they can't tell. That's how it became popular. That's the truth."

Caruso shrugs when asked if his war years those months spent in all kinds of weather, seeing comrades fall affected him, made him the man he became.

"I don't know about that, truthfully," he said. "Maybe I was too young. It didn't affect me that much. Overseas was a long time, but I survived. A lot of guys didn't survive."

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WWII veteran just shy of his 100th birthday says his secret to longevity is his wife - and vodka - USA TODAY

The PIONEER III study enrolled 1,629 patients (randomized 2:1 experimental to control) from North America, Europe and Japan and had a primary composite endpoint of target lesion failure (TLF) at one-year. The TLF outcomes showed that the Supreme HT met the non-inferiority endpoint at 5.4% compared to 5.1% from the DP DES (p=0.002). A grouped analysis of secondary endpoints showed a numerically better result for Supreme HT in cardiac death or target-vessel myocardial infarction (TV MI) with 3.5% in the Supreme HT arm compared to 4.6% in the control arm (p=0.27). Lower late stent thrombosis data (Supreme HT 0.1% compared to DP DES 0.4%, p=0.22) also suggested exceptional safety for the HT DES. A powered, landmark TLF analysis evaluating the healing superiority of Supreme HT between 1 and 5 years is ongoing.

"I am very pleased that Japanese patients will benefit from the most advanced DES in the US, Europe and Japan," said Shigeru Saito, MD, Shonan Kamakura General, Japan and primary investigator of the Japanese cohort of the PIONEER III study . "The results combined with the safety measurement of cardiac death, target vessel MI and late stent thrombosis favor the Supreme HT, supporting the early endothelial healing concept."

Contemporary DES have emphasized delay healing through prolonged drug delivery to suppress the body's response to injury, hypersensitivity, or progression of disease. The Supreme HT development was based on the "wound-healing window" concept originally proposed in 2013 and represents a novel class of DES that highlight the importance of early, timely healing. Through patented designs and proprietary processes, the Supreme HT was tailored to help patients accelerate their wound-healing process and restore their natural endothelial function. This healing-targeted mechanism may help overcome the long-standing problem of tradition-DES implantation, allowing for safer long-term results.

"We are very grateful to the extraordinary group of medical professionals and all the patients who have endured through this difficult pandemic and completed this study milestone in such a timely and professional manor," saidJianhua Sun, PhD., Chairman & Chief Executive Officer of SINOMED."The results have been extremely encouraging and if we reach superiority in the landmark analysis, wecould revolutionize the understanding of healing and the future of implantable devices,"

More information on the PIONEER III study is available at http://www.clinicaltrials.gov, identifier: NCT03168776.

About SINOMED

Sino Medical Science Technology Inc. (SINOMED), a global medical device company engaged in research, development, production, and commercial distribution of interventional devices. We are focused on developing breakthrough technologies to target unmet clinical needs in the interventional treatment of coronary, neurovascular and structural heart disease. Our mission is to expose more patients to the benefits of our medical innovations, increasing patient longevity and quality of life.

For more information, visit: http://www.sinomed.com

SINOMED B.V Cindy Zheng T: +31 10 307 6295 E: [emailprotected]

Photo - https://mma.prnewswire.com/media/1333951/SINOMED_Stent.jpg Logo - https://mma.prnewswire.com/media/1333950/SINOMED_Logo.jpg

SOURCE SINOMED

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Late-Breaking Study Results of the Supreme HT Healing-Targeted DES Demonstrated Equivalent Outcomes with Exceptional Safety - PRNewswire

TIANJIN, China, Nov. 17, 2020 /PRNewswire/ -- SINOMED today announced that Prof. Alexandra Lansky from the Yale School of Medicine, USA, presented data from its first inter-continental PIONEER III study comparing the safety and efficacy of the Supreme HT (Healing-Targeted) Drug-Eluting Stent, to the Xience or Promus Durable Polymer Drug-Eluting Stent (DP DES). One-year results, revealed at the 2020 American Heart Association Scientific Late-Breaking Trials Session, showed equivalent clinical performance of the Supreme HT to the market-leading DES and will be used to support U.S. Food and Drug Administration and Japanese regulatory approvals.

The PIONEER III study enrolled 1,629 patients (randomized 2:1 experimental to control) from North America, Europe and Japan and had a primary composite endpoint of target lesion failure (TLF) at one-year. The TLF outcomes showed that the Supreme HT met the non-inferiority endpoint at 5.4% compared to 5.1% from the DP DES (p=0.002). A grouped analysis of secondary endpoints showed a numerically better result for Supreme HT in cardiac death or target-vessel myocardial infarction (TV MI) with 3.5% in the Supreme HT arm compared to 4.6% in the control arm (p=0.27). Lower late stent thrombosis data (Supreme HT 0.1% compared to DP DES 0.4%, p=0.22) also suggested exceptional safety for the HT DES. A powered, landmark TLF analysis evaluating the healing superiority of Supreme HT between 1 and 5 years is ongoing.

"I am very pleased that Japanese patients will benefit from the most advanced DES in the US, Europe and Japan," said Shigeru Saito, MD, Shonan Kamakura General, Japan and primary investigator of the Japanese cohort of the PIONEER III study . "The results combined with the safety measurement of cardiac death, target vessel MI and late stent thrombosis favor the Supreme HT, supporting the early endothelial healing concept."

Contemporary DES have emphasized delay healing through prolonged drug delivery to suppress the body's response to injury, hypersensitivity, or progression of disease. The Supreme HT development was based on the "wound-healing window" concept originally proposed in 2013 and represents a novel class of DES that highlight the importance of early, timely healing. Through patented designs and proprietary processes, the Supreme HT was tailored to help patients accelerate their wound-healing process and restore their natural endothelial function. This healing-targeted mechanism may help overcome the long-standing problem of tradition-DES implantation, allowing for safer long-term results.

"We are very grateful to the extraordinary group of medical professionals and all the patients who have endured through this difficult pandemic and completed this study milestone in such a timely and professional manor," saidJianhua Sun, PhD., Chairman & Chief Executive Officer of SINOMED."The results have been extremely encouraging and if we reach superiority in the landmark analysis, wecould revolutionize the understanding of healing and the future of implantable devices,"

More information on the PIONEER III study is available at http://www.clinicaltrials.gov, identifier: NCT03168776.

About SINOMED

Sino Medical Science Technology Inc. (SINOMED), a global medical device company engaged in research, development, production, and commercial distribution of interventional devices. We are focused on developing breakthrough technologies to target unmet clinical needs in the interventional treatment of coronary, neurovascular and structural heart disease. Our mission is to expose more patients to the benefits of our medical innovations, increasing patient longevity and quality of life.

For more information, visit: http://www.sinomed.com

SINOMED B.V Cindy Zheng T: +31 10 307 6295 E: cindy.zheng@sinomed.com

Photo - https://mma.prnewswire.com/media/1333951/SINOMED_Stent.jpg Logo - https://mma.prnewswire.com/media/1333950/SINOMED_Logo.jpg

SOURCE SINOMED

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Late-Breaking Study Results of the Supreme HT(TM) Healing-Targeted DES Demonstrated Equivalent Outco - PharmiWeb.com

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Longevity and Anti-senescence Therapy Market | Business Outlook with COVID-19 Scenario - TechnoWeekly

Loneliness is a prevalent and serious public health problem impacting health, well-being and longevity. Seeking to develop effective interventions, researchers at University of California, San Diego School of Medicine examined the psychological and environmental factors that lead to patterns of loneliness in different age groups.

Researchers used a web-based survey of 2,843 participants, ages 20 to 69 years, from across the United States.

The study, published in the November 10, 2020 online edition of the Journal of Clinical Psychiatry, found that levels of loneliness were highest in the 20s and lowest in the 60s, with another peak in the mid-40s.

What we found was a range of predictors of loneliness across the lifespan, said corresponding senior author Dilip V. Jeste, M.D., senior associate dean for Healthy Aging and Distinguished Professor of Psychiatry and Neurosciences at UC San Diego School of Medicine.

The researchers noted that lower levels of empathy and compassion, smaller social networks, not having a spouse or a partner and greater sleep disturbances were consistent predictors of loneliness across all decades. Lower social self-efficacy or the ability to reflect confidence in exerting control over ones own motivation, behavior and social environment and higher anxiety were associated with worse loneliness in all age decades, except the 60s.

Loneliness was also associated with a lower level of decisiveness in the 50s.

The study confirmed previous reports of a strong inverse association between loneliness and wisdom, especially the pro-social behaviors component (empathy and compassion).

Compassion seems to reduce the level of loneliness at all ages, probably by enabling individuals to accurately perceive and interpret others emotions along with helpful behavior toward others, and thereby increasing their own social self-efficacy and social networks, said Jeste.

The survey suggested that people in their 20s were dealing with high stress and pressure while trying to establish a career and find a life partner.

A lot of people in this decade are also constantly comparing themselves on social media and are concerned about how many likes and followers they have, said Tanya Nguyen, Ph.D., first author of the study and assistant clinical professor in the Department of Psychiatry at UC San Diego School of Medicine. The lower level of self-efficacy may lead to greater loneliness.

People in their 40s start to experience physical challenges and health issues, such as high blood pressure and diabetes.

Individuals may start to lose loved ones close to them and their children are growing up and are becoming more independent. This greatly impacts self-purpose and may cause a shift in self-identify, resulting in increased loneliness, said Nguyen.

Jeste said the findings are especially relevant during the COVID-19 global pandemic.

We want to understand what strategies may be effective in reducing loneliness during this challenging time, said Jeste. Loneliness is worsened by the physical distancing that is necessary to stop the spread of the pandemic.

Nguyen said intervention and prevention efforts should consider stage-of-life issues. There is a need for a personalized and nuanced prioritizing of prevention targets in different groups of people, said Jeste.

Co-authors include: Ellen Lee, Rebecca Daly, Tsung-Chin Wu, Yi Tang, Xin Tu, Ryan Van Patten, and Barton Palmer, all at UC San Diego.

Funding for this study came, in part, from the National Institute of Health (grants K23 MH118435, K23 MH119375, T32 MH019934, and R01 MH094151); UC San Diego Center for Healthy Aging; and the Department of Veterans Affairs.

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Study: Loneliness highest in the 20s and lowest in the 60s - University of California