Category Archives: Longevity Medicine

DURHAM, N.C. A Duke-led team of scientists has developed a bio-compatible surgical patch that releases non-opioid painkillers directly to the site of a wound for days and then dissolves away.

The polymer patch provides a controlled release of a drug that blocks the enzyme COX-2 (cyclooxygenase-2,) which drives pain and inflammation. The study appears Jan. 10, 2021 in the Journal of Controlled Release.

When they started We were making hernia meshes and different antimicrobial films, said Matthew Becker, the Hugo L. Blomquist professor chemistry at Duke, and last author on the paper. We thought you could potentially put pain drugs or anesthetics in the film if you just sew it in as you're stitching the person up, then you wouldn't necessarily have to prescribe any opioids, Becker said.

The work grew out of a $2 million grant Becker received from the state of Ohio at his previous institution to investigate non-opioid pain management , one measure toward fighting a nationwide epidemic of opioid drug abuse. Since arriving at Duke in 2019, Beckers team has partnered with Duke pain control expert Dr. Ru-Rong Ji and his team to refine the idea.

The polymer itself, comprised of poly(ester urea) homopolymers and co-polymers, is also special, said Becker, who is also a professor of mechanical engineering and materials science in Duke's Pratt School of Engineering.

Most polymers that are used in medicine swell, and everything comes out at once, Becker said. But this polymer erodes slowly, and its painkiller dose and longevity can be controlled simply by varying the surface area and thicknesses. The film is about like a piece of paper.

If you can get four or five days of pain control out of the patch and not have to take those other pain drugs, not only do you avoid some of the side effects and risks of addiction, youre concentrating therapy where you need it, Becker said.

Rat studies also showed that the painkiller stayed in tissues close to the patch site, rather than dissolving into circulating plasma.

Becker said the patch should be able to provide three or four days of wound-pain management, which is the critical period for post-surgical pain. The implantable film would be particularly useful in endoscopic procedures and instances where the physicians and patients would like to avoid opioid exposure such as Cesarean births and pediatric surgeries. In studies with mice that mimic the neuropathic pain of diabetes, the pain patch was placed against a nerve and provided a four-day nerve block.

This research was sponsored by Merck Sharp & Dohme Corp, 21st Century Medical Technologies and the Ohio Third Frontier Opioid Challenge. Becker and co-author Natasha Brigham have filed provisional patent applications with the University of Akron Research Foundation. Becker also is a board member and equity holder in 21st Century Medical Technologies.

CITATION: Controlled Release of Etoricoxib from Poly(ester urea) Films for Post-Operative Pain Management, Natasha Brigham, Rebecca Nofsinger, Xin Luo, Nathan Dreger, Alexandra Abel, Tiffany Gustafson, Seth Forster, Andre Hermans, Ru-Rong Ji, Matthew Becker. Journal of Controlled Release, Jan. 10, 2021. DOI: 10.1016/j.jconrel.2020.11.052

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Post-Surgical Patch Releases Non-Opioid Painkiller Directly to the Wound - Duke Today

CHICAGO, Jan. 14, 2021 /PRNewswire/ --Newsweek global top-10, Israel-based Sheba Medical Center, world-renowned for its innovation model known as ARC (Accelerate, Redesign, Collaborate), has signed an official deal led by Kaleidoscope Health Ventures. Sheba, together with Kaleidoscope and Farpoint Development, are entering a joint venture to develop, execute and lead the Chicago ARC Innovation Center based on a shared vision for the transformation of health care.

The JV unites the successful ARC open collaboration modela repeatable prototype that exemplifies Israel's "Startup Nation" mindsetwith a market-driven approach adapted for the U.S.The center will be an anchor for the $7 billion, 100-acre Bronzeville Lakefront development on the historic site of the Michael Reese Medical Center.

The Chicago ARC will give international companies a U.S. foothold, develop health disparity solutions, incubate health innovation startups, collaborate on data science initiatives and be a gateway for global investment.

Chicago ARC Innovation Center Is Unique, With Many Firsts

The Chicago ARC aims to create billions of dollars in value and dramatically accelerate the successful adoption and adaptation of disruptive technologies. Under the leadership of the JV team, the Chicago ARC will foster new capabilities that grow health ventures through access to data, experienced operators, customers and capital. Focus areas include precision medicine, big data and artificial intelligence, virtual reality, telehealth and medical technologies. The Chicago ARC model includes:

Chicago Is Ground Zero for Global Health Innovation

Illinois has all the ingredients to create better health outcomes. It is among the nation's top producers of STEM degrees and is home to the third largest medical and life science economic engine in the nation. World Business Chicago reported that the Chicago region generates approximately $72 billion in economic output and supports almost 700,000 employees annually. As one of only four U.S. cities with three tier-one research universities, Chicago area institutions amassed over $900 million in National Institutes of Health-funded research and development funding as of 2019.

"The Chicago ARCwill enhance our incredible reserve of STEM talent, expand our next generation life sciences ecosystem and attract further capital to accelerate growth, while also serving asa transformational epicenter geared toward creating healthcare equity across our city's South Side communities," Mayor Lori E. Lightfoot said.

"Given these assets, and the extensive preexisting global partnerships brought by ARC to Chicago, this new venture sets the stage for the development of a new global innovation model. It will be a model that fuels the kind of transformative and collaborative change every life sciences innovation hub should aim to createa model from the start that is focused on inclusion and designed to use assets across communities, states and countries," P33 CEO Brad Henderson said.

This announcement comes on the heels of recent announcements that demonstrate Chicago's goal, and ability, to become a global innovation destination. "We've already been recognized for our leadership in quantum science and in startup exit value," Henderson said. PitchBook just recognized Chicago as the top U.S. city for exit value fueled by VC investment in 2020.

"We're focused on building transformative partnerships that improve economic growth and equity in our city, and Sheba's first physical U.S. innovation center gives us a tremendous opportunity to further this goal. Given our depth of talent and entrepreneurial spirit, Chicago will be able to serve as the epicenter for their North American partnerships and help create a world class healthcare innovation hub," World Business Chicago Interim President & CEO Michael Fassnacht said."We welcome Chicago ARC's vision and the JV team's expertise in innovation and inclusivity to carry on the legacy of the formerMichael Reese Medical Center."

Healthcare Equity Is the Underlying Mission

"Our primary purpose goes beyond turning scientific discovery into financial returns; it's about turning scientific discovery into scalable innovation that drives health equity for all. The Chicago ARC redesigns the way healthcare innovation is done to achieve this commitment. It's an especially critical goal in Chicago because there's a 30-year life expectancy gap between the city's poorest and wealthiest ZIP codes," Kaleidoscope Co-founder S. Bob Chib noted.

"Tackling pressing health challenges through a collaborative platform will bring solutions to the market faster that not only generate significant financial returns but also enable health, social and economic justice throughout our state and nation," Kaleidoscope Co-founder Ken Bahk added.

"The Chicago ARC is an ideal catalyst for the Bronzeville Lakefront development, which we envision as a healthy neighborhood of the future. We plan to break ground in mid-2021. In the interim, the Chicago ARC will operate from a nearby space and move to the Bronzeville Lakefront site when the 500,000-square-foot facility is completed in Q4 2023," Farpoint Managing Principal Scott Goodman said.

"The Bronzeville community has been a center of medical innovation for more than 125 years. Dr. Daniel Hale Williams performed the first successful open-heart surgery here in 1893 at Provident Hospital, the nation's first nonsegregated hospital which he also founded in 1891. It's fitting that Sheba's ARC Innovation Center will anchor, with an equity lens, the anticipated Bronzeville Lakefront development on the former site ofthe historic Michael Reese Hospital. It will continue our community's consequential legacy in developing life science solutions with global impact," Alderman Sophia King (4th) said.

Israel and Sheba Are Committed

"The ARC Innovation Center aligns with one of Israel's greatest prioritiesthe transformation of health care. COVID-19 has reinforced how important it is to address and achieve health equity, making new and smarter healthcare approaches even more urgent and pressing," Sheba Deputy Director General, Chief Medical Officer and Chief Innovation Officer Dr. Eyal Zimlichman said.

"Transforming health requires more than a single institution or nation,which is why global collaboration is so important. Israel, and Sheba as its national medical center, started the journey long ago to disrupt health care through groundbreaking technology. TheChicago ARC Innovation Centerwill expand our efforts in the largest global market,"Sheba Director General Prof. Yitshak Kreiss added.

"With Sheba's expertise in healthcare innovation, the leadership of Chicago and a pioneering joint venture, this partnership will help drive health equity and economic growth throughout the entire city and beyond for decades," Chicago's Israeli Counsel General Aviv Ezra noted. "The Consulate's partnership with Kaleidoscope and this initiative has been one of our main focuses during my time as Consul General in Chicago. It's a win-win for everyone."

About the Chicago ARC Innovation Center Joint Venture Partners

Sheba, Kaleidoscope and Farpoint are partnering to realize a new model for holistic health, wellness and longevity by connecting the best science, talent, technology and data globally. The team has engineered the Bronzeville Lakefront planned development as an ESG-aligned health and wellness innovation hub to attract strategic partners and investors. The partners have proven track records in developing and executing notable projects and decades of successful leadership in their respective fields, as noted here:

About P33

About World Business Chicago

Contact:Kellie Quinn, [emailprotected]

SOURCE Kaleidoscope Health Ventures

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P33 and Mayor Lori E. Lightfoot, Together With Joint Venture Team Kaleidoscope Health Ventures, Farpoint Development and Israel's Sheba Medical...

Americans are living longer than ever before about 30 years longer, on average, than a century ago according to leading scholars who participated in the Century Summit, a four-day virtual conference convened in December by The Longevity Project and the Stanford Center on Longevity. The conference looked at everything from business innovations to caregiving to new ways for Americans to work and thrive throughout the increasingly long lives they're now living.

"Longevity is ... among the greatest opportunities we have had in human history," Psychologist Laura Carstensen, founding director of the Stanford Center on Longevity, said. "Essentially, our ancestors handed us 30 extra years of life with no strings attached. It's up to us to make sure that we use these years to improve quality of life, not just in old age but at every stage in life."

Researcher Susan Golden said adults 50 and older now represent 35% of the nation's population and account for more than 50% of consumer spending and 83% of household wealth.

That huge market of older adults is beginning to attract "A-level entrepreneurs, who could be doing anything," Robert Chess, a biotech entrepreneur and Stanford business lecturer, said.

"They're coming in and reinventing areas that have traditionally been the purview of nonprofits and mom-and-pop businesses," Chess said, citing a startup called Wider Circle focused on alleviating senior loneliness and another called Honor that specializes in the field of home health care.

Even iconic global brands with youthful images have embraced the aging customer base, making "stealth" changes to retain this group, he said.

"You think of BMW, the 'ultimate driving machine,' with 30- and 40-year-old marketing and demographics," Chess said. But the average age of a new BMW owner is actually 56.

The Bavarian auto giant redesigned its dashboard and controls with more color contrast, larger type and bigger knobs, without ever announcing it, Chess said.

"It works really well for older people, but they don't quite know why. It works well for the younger people. But (BMW) is still marketing the same way they always have. It's essentially stealth design," he said.

Similarly, Nike finding it was losing customers as they got into their 50s, 60s and 70s introduced the CruzrOne athletic shoe.

"The marketing is 'athlete forever,' so they're not marketing it toward older people, they're marketing it for cross-generation," Chess said.

"But it has features such as a flexible back heel so it's easier to get in and out of the shoe. It has more stability control; it has more padding because as your feet get older the padding gets thinner all things that are just good for everybody."

Chess said the CruzrOne was inspired by 82-year-old Nike founder Phil Knight, who walks eight miles a day.

Despite its youthful image, eyewear maker Warby Parker has found that its fastest-growing market segment is people 60 and above, Chess said. "So, they provide all the features needed (by older customers, such as progressive lenses) but still keep their young market. What you're seeing is companies that have young brands but are going where the growth is.

"They're doing it by providing product features that work for everybody but are needed by the older people."

In seeking to lead longer and healthier lives, Americans should consider emulating the nation's Latino population, David Hayes-Bautista, a professor of medicine and director of the Center for the Study of Latino Health and Culture at the Geffen School of Medicine at UCLA, told participants at the conference.

Latinos in the United States enjoy longer life expectancies and lower death rates from heart disease, cancer and other causes than non-Hispanic whites, said Hayes-Bautista, citing data from the National Center for Health Statistics.

Hayes-Bautista, who's spent 40 years studying the health and culture of Latinos in the United States, said the group can be considered a model for longer, engaged lives. Latinos in the U.S. enjoy nearly 3 1/2 years of longer life expectancy 81.8 years than non-Hispanic whites, at 78.5 years, he said.

"That's surprising because they have less income as a population, less education, lower access to care, but they manage to live 3 1/2 years longer," he said.

Similarly, U.S. Latinos have 30% lower age-adjusted death rates from several leading causes of death, including heart disease and cancer, he added.

The reasons, in part, have to do with "some behaviors, which are counter-intuitive," Hayes-Bautista said. Latinos are about 30% less likely to use tobacco and alcohol and 40% less likely to use drugs, he said.

"This surprises a lot of people because the stereotype is the drunken Mexican, etc., etc.," he said. "And part of this may be due to some dedication to work."

Latinos consistently have a higher rate of labor force participation and a higher rate of household formation than non-Latinos, he said, citing data from the U.S. Census Bureau.

"We don't have to re-invent anything," Hayes-Bautista said. "If we want to increase life expectancy, lower mortality, keep people engaged and have big families, actually Latinos have been doing that ... We just need to understand and appreciate what's under our nose right here in this country."

For more information or recordings of the Century Summit go to longevity.stanford.edu/century-summit.

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Americans are living 30 years longer on average and that's a big plus for businesses - Palo Alto Online

Last week, C.N. indicated she needed a little lift during this COVID time and asked what the Successful Aging column could do to help. As part of an HBO special, we showcased quips from four legendary comedians in their 90s: Carl Reiner, Norman Lear, Mel Brooks and Dick Van Dyck.

This week we feature quotes from four women in their 90s for a bit more levity with a message.

Age doesnt matter according to Angela Lansbury. Lansbury, age 95, has been on stage, television and in films for over 70 years, never permitting her chronological age to hold her back. She has said, Ive never been particularly aware of my age. Its like being on a bicycle I just put my foot down and keep going.

What we know. During childhood, there are expected age-related milestones in a childs development, such as when the child walks, talks and can read. Thats not the case for older adults. Expectations about how older adults look, behave and think are not based on developmental stages but on social expectations which often is an excuse for ageism. Most older adults keep going regardless of their age.

Betty White advocates getting enough sleep. As a 98-year old actress and comedian, White has a television career spanning 80 years and has worked longer in the industry than anyone else. In promoting sleep, she says, Get at least eight hours of beauty sleep, nine if youre ugly.

What we know. Sleep is considered an important part of our routine and is essential for survival as is food and water. Recent research suggests that sleep has a housekeeping role by removing toxins in our brain that accumulate when we are awake. For older adults, less than seven hours of sleep a night generally is considered insufficient The American Academy of Sleep Medicine refers to a study by UCLA researchers who discovered that just a single night of insufficient sleep can make older adults cells age quicker. For a good read on sleep, see The Sleep Revolution: Transforming Your Life One Night at a Time by Arianna Huffington (Harmony Books, 2017).

Iris Apfel believes in authenticity. Apfel, age 99, is a businesswoman, interior designer, model and considered the worlds oldest fashion icon. She describes herself as a geriatric starlet, known for her brightly colored clothing, layered jewelry and oversized glasses. There is even a Barbie doll modeled after her. She says, When you dont dress like everyone else then you dont have to think like everyone else. She adds, I always dressed for myself and dont care what anybody thinks.

What we know. With age we have the opportunity to become more of ourselves and less reliant on fulfilling expectations of others. Authenticity refers to the characteristics, roles or attributes that define who we are, even if they are different from how we may act.With age there is a tendency to see ourselves as more authentic, according to researchers Elizabeth Seto and Rebecca J. Schlegel.

Dr. Ruth views life in a positive way. Ruth Westheimer, age 92, is a sex therapist, author, media personality and talk-show host. She says, I actually look for things to smile about. In a 2019 interview she indicated as a Holocaust survivor, she defused anxiety and shame by focusing on the present and using humor and charm.

What we know. Having a positive attitude not only makes us feel good, it effects our longevity. A study from the Boston University School of Medicine found that after decades of research, those who were more optimistic about life lived longer, often to age 85 and older. Researchers suggest several reasons. More optimistic people may be able to regulate their emotions and behavior more effectively as well as their ability to bounce back from difficult situations. Furthermore, they may have healthier lifestyle habits.

Thank you C.N. for your good question. These women in their 90s have lived and seen a lot. During the current climate, some of their tips might be useful: Dont let age hold you back, stay positive and authentic and of course, get enough sleep. Above all, stay safe and be well and kind to yourself and others.

Helen Dennis is a nationally recognized leader on issues of aging, employment and the new retirement with academic, corporate and nonprofit experience. Contact Helen with your questions and comments at Helendenn@gmail.com. Visit Helen at HelenMdennis.com and follow her on facebook.com/SuccessfulagingCommunity

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4 female celebrities in their 90s offer tips for living a long and fulfilling life - The Mercury News

The fallout from COVID-19 is driving huge investment within AI and nanotechnology, with healthcare investment expected to grow at a rate of nearly 50% more a year towards a market set to be worth $1.333 trillion by 2027, according to Vector Innovation Fund.

The acceleration highlights wide recognition that the world cannot afford the human and economic cost of another pandemic, it says.

At present, 70% of global healthcare provision is spent on providing care for the last few months of our lives.

It is further accepted that the pandemic has shown the inefficiency of the worlds centralised healthcare model and its poor outcomes, with far reaching economic effects and negative impacts on treating cancers, mental health, cardio-vascular conditions, and the emerging challenge from Long COVID.

But observers say this will now trigger the greatest transformation of investment in advanced healthcare technologies since World War II.

These include sophisticated nanotechnology-based diagnostics, biomarkers, vaccines, novel therapies, highly targeted nanomedicines and AI, allowing us to move to a more sustainable, digitised, decentralised and democratised point-of-care environment.

"With dynamic investment these will free our economies and future-proof us from infectious diseases as well as develop solutions to antibiotic resistance, another global healthcare challenge that only technology can solve," VIF says.

"Investors are already switching to this accelerated model, away from traditional healthcare infrastructure and onto point of care and precision medicine.

"This delivers sustainable healthcare economics as well as improving life and longevity. Such investment is expected to bring transformational impact and returns over the next decade and beyond."

This trend was apparent before COVID-19 but investment in healthcare technology in the second half of 2020 has already reached record levels and is set to climb significantly over the next decade.

One particular investment group has developed a unique gateway fund to innovative and disruptive technologies, targeting current and future pandemics, as well as transforming global healthcare.

This international investment platform operated by Vector Innovation Fund G-P Srl, is registered and regulated as an Alternative International Investment Fund, domiciled in Luxembourg due to the country's world class reputation for tax efficiency and regulatory standards. This highly innovative fund is attractive and available only to sophisticated international, UHNW, family office, sovereign wealth, and other institutional investors.

Vector Innovation Fund (VIF) has now launched a $300 million sub-fund for pandemic protection and future healthcare, aiding and supporting precision medicine, highly advanced point of care and AI technologies to support the global economy, sustainable healthcare, and life longevity.

Paul Stannard, chairman and general partner of VIF, says, "Politicians are always forced to defend our old, centralised healthcare model but the pandemic has proved beyond doubt its not fit for purpose.

"A new approach to emerging technologies is vital," he says.

"We have brought together some of the worlds leading figures in biomedicine, advanced diagnostics, nano biomarkers, telemedicine, AI and machine learning to accelerate these transformational technologies into the markets, backed by sophisticated and institutional investors creating one of the most dynamic international investment structures," Stannard explains.

"Globally, we have had to deal with Ebola, Zika Virus, Bird Flu, and now COVID-19 in one decade, but the economy must adapt to a new future, where prevention and early intervention as well as using AI to drive more sustainable models for healthcare and investment."

One example of this is the profound change in telemedicine in just a few months. These technology solutions for GPs and patients, have allowed us to monitor and support many more patients during this pandemic the start of an unstoppable transformation.

Stannard says previous investment criteria were holding back innovation and only reinforcing the broken property-focused and centralised models for healthcare. Innovators have proved that they can develop and commercialise novel technologies and have some approved within months, not years, and this trend will advance beyond the current crisis, which is creating this groundswell of pent-up investment in advanced technologies.

"Our team have an excellent track record in industry, healthcare, technology and investment, with 21 exits and a total value creation of $2.4 billion, including two successful IPOs," he says.

A recent report by KPMG and HFS Research highlighted how companies and governments need to make smart investments in emerging technologies if they are to prevail against future pandemics: 65% of 900 global executives polled said: We don't have a choice or we risk threatening our very existence.

Paul Sheedy, founder of The World Nano Foundation, an international not-for-profit organisation for the commercialisation of nanoscale technologies, adds, "Nanomedicine and the decoding of the genome have been enhancing healthcare for a number of years, but the pandemic has catapulted healthcare investment creating a hockey stick effect for investors.

"This includes vastly improved home testing and advanced diagnostics where we know outcomes are significantly improved through early intervention," he says.

"Added to this, highly targeted precision medicines or therapies are going to transform all forms of healthcare, allowing us to work in parallel with and then ultimately move away from the current archaic centralised healthcare system delivery."

Nanotechnology is forecast to more than double from $54.2 billion this year to $126.8 billion by 2027 and will create a positive force for change when combined with AI and machine learning, forecast on its own to soar 22.5% a year through to 2027 from a $284.38 billion market in 2019.

"We are going to see these twin forces of innovation transform how we live, work, and manage our health in real time as well as develop sustainable models for everything from food production and energy to transport and pollution, all of which improve health and well-being.

"The world of philanthropy and impact investing is also undergoing significant change as we realise that we must advance everything from healthcare for all with more affordable point of care to climate change, improved biodiversity, and reversing pollution."

Naz Bashir, trustee of global technology charity World Science Aid, says, "The world has suddenly woken up to the fact that the global challenges of healthcare, pollution and climate change must now be tackled head on.

"The pandemic has proved that money has no value without sustainable life and a stable economy. The world has reinforced the mistakes of supporting tired funding models for too long, and one positive outcome from the current global crisis is recognition that we now need to invest for the future, and these new technologies can right some of the wrongs of the past.

"For instance, two billion of the worlds seven billion people still do not have access to clean water or simple point of care technology," says Bashir.

"The next generation deserve and demand a better future that these enabling technologies can offer our governments and investors towards building a better post-pandemic future."

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Investment in AI and nanotech surges in wake of COVID-19 - IT Brief Australia

The Global Longevity and Anti-senescence Therapy Market comprises market size, status, and growth rate for the forecast period 2021-2026. The report offers fundamental data to readers, strategists, senior administration, and advertisers associated with the market. This unique and updated report precisely presents each and every aspect of the Global Longevity and Anti-senescence Therapy industry and represents it in an easy to understandable format. Alongside, researchers have broken down the market into various key verticals. Longevity and Anti-senescence Therapy market also covers industry-oriented drivers, restraints, threats, and opportunities in the market.

North America has a significant international presence in the global Longevity and Anti-senescence Therapy market in 2021 accompanied by the Middle East/Africa, Europe, and the Asia Pacific, respectively.

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The report tracks the global Longevity and Anti-senescence Therapy market competitors, status, share, future trends, growth rate, sales, SWOT analysis, channels, distributors, and development plans for forecast period 2021 to 2026. In addition to this, the import & export status and revenue figures are also added. The report is categorized into key geographical regions, sub-regions, major segments like types and applications.

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Major Players in the Longevity and Anti-senescence Therapy Market report included are: Acorda Therapeutics, Unity Biotechnology, Antoxerene, Celgene, Cohbar, Senex Biotechnology, Human Longevity Inc., T.A. Sciences, Agex Therapeutics, Recursion Pharmaceuticals, Calico Life Sciences, Spotlight Bioscience, Powervision Inc., Sierra Sciences Llc, Restorbio, Insilico Medicine, Oisin Biotechnology, Senolytic Therapeutics, Proteostasis Therapeutics Inc., Prana Biotechnology Ltd., Cleara Biotech

Longevity and Anti-senescence Therapy Market Segmentation by Product types:

Applications covered in the report are:

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Key Geographical Regions included in this report: United States, Europe, China, Japan, Southeast Asia, India, Central & South America

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Longevity and Anti-senescence Therapy Market Size and Growth Factors Research and Projection 2026 - Farming Sector