Category Archives: David Sinclair

You might have heard about Dr. David Sinclair on the Joe Rogan Experienceand you are now curious about what does he eat and what supplements he does take.

Together with Dr. Rhonda Patrick, he is one of the main proponents of wholesome food eating to delay aging.

In this post, you will get all Dr. David Sinclair' anti-aging tips so that you can slow down your own aging.

David Andrew Sinclair (born 1969 in Australia) is a biologist and professor of genetics. In the longevity circles, he is known for supporting resveratrol (one of the compounds found in red wine) as a supplement to slow the aging process.

What Companies Does David Sinclair Own?

Dr. David Sinclair is co-founder of several biotechnology companies (Sirtris Pharmaceuticals, Genocea Biosciences, OvaScience, CohBar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others (most notably Shaklee).

Is David Sinclair Legit?

Yes, David Sinclair is legit. He holds a PhD from the University of New South Wales (Sydney, Australia) and is a Full Professor at Harvard where is working since 1999. He is author of hundreds of peer-reviewed scientific publications.

Is David Sinclair Vegetarian?

David Sinclair is not vegetarian. Nevertheless, he limits his red meat consumption because it contains Trimethylamine N-oxide which is associated with an increased risk of heart disease.

What Does Dr. David Sinclair Eat?

As you are interested in extending your life span, you might be interested in knowing what David Sinclair eats so that you can also gain some benefits.

David Sinclair's diet consists of:

What Supplements Does David Sinclair Take?

The anti-aging doctor keeps it simple when it comes to longevity supplements.

Here the list and dosage of anti-aging supplements that David Sinclair takes (from the Joe Rogan podcast):

He has been taking resveratrol for 12 years while NMN and metformin for about 3.

To properly absorb resveratrol make sure to have some fat when you take it. For example you can have some whole milk, full fat yogurt, or some nuts.

Due to a family history of high cholesterol, he also takes a statin but it doesn't mean that you need as an anti-aging supplement.

Watch out: NMN can be pretty expensive!

Where Can You Buy Metformin?

To get metformin, you would need a prescription from your doctor. This is not always easy to come by as it depends from doctor to doctor to make the final call.

As alternative, you can substitute it with berberine which you can easily find on Amazon.

Why NMN For Longevity?

Calorie restriction is the best "therapy" against aging.

You can imagine, though, that it's not sustainable as a long term solution not only because you'd be constantly hungry but also because you'd be malnourished.

When we get older, our levels of NAD+ decline. Calorie restriction, can reverse the decline of NAD+.

The problem of NAD+ is that if you were to take it (either as a pill or inject it), it is poorly absorbed by the cells. This means that it cannot work.

Interestingly, when older mice were fed NMN, they had the same NAD+ levels of younger mice. Cool, isn't it?

Supplements He Does NOT Recommend

There are some supplements that Dave Sinclair does not recommend either for safety reasons or because they can accelerate aging:

David Sinclair Workouts

David Sinclair runs one to two times per week at fairly high intensity on the Assault Fitness AirRunner.

Two to three times per week he does resistance training and boxes. No specific details are available at the moment. He frequently uses a sauna in conjunction with a cold bath.

David Sinclair Longevity Tips

David Sinclair Book

If you have found Dr. David Sinclair' tips valuable, you will just devour his book: "Lifespan: Why We Ageand Why We Don't Have To".

In the book he goes in great detail on how we can slow down, or even reverse, aging. Check it out on Amazon.

David Sinclair on Joe Rogan's Podcast

David Sinclair on Rich Roll's Podcast

David Sinclair on Peter Attia's Podcast

Go here to read the rest:

What Does David Sinclair Eat and Supplement? (2019 ...

David Sinclair is a professor of genetics at the forefront of anti-aging research.

I've taken note of his work, and as someone extremely interested in maximizing my longevity and vitality, I have incorporated a couple of his daily supplements into my own routine that I wasn't already using.

These are the supplements and drugs he uses to preserve his youth.

David Sinclair's takes 500 mg of Resveratrol with yogurt upon waking up.

Resveratrol is a natural phenol produced by plants when they are under attack by pathogens, or in response to injury.

It is essentially produced as a defense mechanism, and interestingly enough, when humans ingest it, it is purported to produce a similar hormetic that activates certain longevity pathways.

In addition to Resveratrol, David Sinclair takes one gram (1,000 mg) of Nicotinamide Mononucleotide (NMN) at the same time each morning with his homemade yogurt.

David takes raw NMN powder, but NMN is also available in tablet form.

A common misconception is that NMN is the same as NR (Nicotinamide Riboside), and they are often confused with one another.

The main difference between the two is the molecule size, which will likely impact how it is absorbed and assimilated.

People often get confused between the two and they'll buy NR supplements, and think that they're getting NMN, but that's often not the case.

I'm not going to say one is superior to the other because NMN has less data on it than NR.

NR is the one that has human trials to show that it boosts NAD+ a significant amount.

There's going to be more data coming on NMN in the near future, but for now, NR seems to be a more predictable bet in terms of choosing between the two.

Obviously, David Sinclair has a lot of confidence in NMN as he's using the research chemical on himself, which I'm not against personally.

It all comes down to risk tolerance when using anything without sufficient human data.

The mechanism of action of both NR and NMN essentially boil down to the fact that they can significantly boost NAD+ levels in the body, which is something that the body produces significantly smaller amounts of as you age.

By supplementing with an exogenous NAD+ precursor and boosting levels up to that of a young health adult, it is theorized that one can maintain healthier cell function in the body in old age and lower the incidence of disease, degradation, and a decline in quality of life.

Personally, I use Nicotinamide Riboside (NR) because it is more cost effective right now, and it has human data to back up its efficacy and safety profile.

I take 2 servings of ResveraCel per day as of now.

ResveraCel is a NR supplement that also contains Resveratrol and Trimethylglycine (TMG).

Something less commonly spoken about is that TMG may be essential to use as a methyl donor alongside NR or NMN, depending on your genetic predisposition, in order to prevent deleterious effects from occurring.

In addition, David Sinclair takes Vitamin D-3 with vitamin K2.

First of all, I can tell you right now that contrary to popular belief, you're not going to get enough Vitamin D from the sun outside, regardless of how long you're out there.

It's very likely that you're going to need to supplement with it.

I highly advise you get a blood test to see where your vitamin D levels are at (I recommend getting a comprehensive health panel while you're at it).

HOW IT WORKS1. Click blood test link above and it will redirect you to Private MD Labs Website

2. Select Male Athletic Anti-Aging Panel and add to cart

3. Add a Vit D, 25 Hydroxy test to it

4. Use DC15 as a discount code for 15% off

They will email you a form that you will print out and take to the nearest Labcorp for the blood draw (the site will guide you to the nearest lab).

Then they email you the results within about 3 business days.

Vitamin D is crucial and a super cheap supplement too.

Get your blood test, see where you're at, and then create a protocol based on how much you need.

Personally, I take 8,000 IUs of Vitamin D-3 per day.

8000 IUs would be considered a mega-dose by many, but this is what it puts my blood work at:

As far as a Vitamin K2, that's something that you can get from egg yolks, butter, dark chicken meat, cheese, Natto, and a variety of other foods.

However, I do not believe that most people are hitting their requirements for Vitamin K2, and certainly not the vitamin K2 homologue MK-7.

MK-7 is thought by many to be the most beneficial Vitamin K2 homologue.

There is an abundance of information all over the web that can be overwhelming to take in.

My advice would simply be to hit the daily requirements for all of the Vitamin K homologues.

Vitamin K2 is the only vitamin that's proven to support arteriosclerosis reversal, the attenuation of further arterial calcification, and scavenging plaque in the arteries.

A high menaquinone intake reduces the incidence of coronary heart disease.

Vitamin K Dependent Proteins and the Role of Vitamin K2 in the Modulation of Vascular Calcification: A Review

Vitamin K-Antagonists Accelerate Atherosclerotic Calcification and Induce a Vulnerable Plaque Phenotype

Dietary Intake of Menaquinone Is Associated with a Reduced Risk of Coronary Heart Disease: The Rotterdam Study

Vitamin K Status and Vascular Calcification: Evidence from Observational and Clinical Studies

Effect of vitamin K2 on progression of atherosclerosis and vascular calcification in nondialyzed patients with chronic kidney disease stages 3-5.

Vitamin K2 is responsible for getting calcium into where it's supposed to go in the body and preventing calcification in the arteries,

If you're deficient in vitamin K2, you're not going to have sufficient assimilation of that calcium into where you want it to be, and you may experience arterial calcification if your diet model supports it (most diets aren't optimized to avoid this).

I would advise a 1 soft gel of the Jarrow Formulas Vitamin K-Complex per day.

If you've seen my other articles on health supplements, you'll know that I've used this product for a while now.

It's one of the main supplements that you should religiously take, especially if you're a bodybuilder.

K2 is a more obscure vitamin that not a lot of people look at seriously, but it's one of the most important ones in my opinion.

David Sinclair also takes a Statin, which is not a supplement, it's a prescription drug for modulating lipids/cholesterol levels.

I don't advise that you haphazardly take a Statin just because David uses 0ne.

There are natural ways to improve your lipid profile, and you may not even have a poor one to begin with.

Again, this is only something that would be recommended by your doctor based on your current blood work should you have a genetic predisposition to poor lipids that cannot be corrected via diet, supplementation and lifestyle changes.

David Sinclair also takes 1 gram (1,000 mg) of Metformin per day.

He started with 500 mg per day, and then he bumped it up to one gram.

One of the main side effects of Metformin is impaired digestion, so I'm assuming that's why he started lower and titrated up to 1 gram.

Metformin is a drug that is typically given to type II diabetics to increase insulin sensitivity and control their blood sugar.

Chronically elevated blood sugar and insulin levels are thought to be one of the main causes of cancer, microbiome disturbances, and cardiovascular disease.

This all stems back to diets including crappy food and sugar, and things that spike inflammation in the body, thus causing:

If you get your insulin sensitivity up, it will not only help lower the incidence of the aforementioned issues, it promotes a healthier body composition as well.

There are a myriad of benefits that come from being insulin sensitive.

This includes muscle growth potential.

If you're weight training and eating in a calorie surplus, you will gain a far more favorable ratio of muscle to fat if you are insulin sensitive as opposed to if you had insulin resistance.

Insulin acts as a nutrient transporter in the body, and if you have severe insulin resistance, you will assimilate nutrients very poorly and experience countless negative consequences, not only on your health, but your body composition and results in your athletic endeavors.

Getting as insulin sensitive as possible is not just conducive to health and longevity, it's also something that's going to improve how you physically look, as well as how lean or how muscular you can get.

I thought David Sinclair would have some massive supplement stack.

I use more supplements than him, which surprised me.

It just goes to show what areas he feels hold the significant majority of importance.

Obviously, he has a lot of confidence in this NAD+ theory and Hormesis.

Insulin sensitivity is also greatly taken into account because he's not diabetic, but he's taking Metformin anyways.

Of the supplements and drugs mentioned, I take Resveratrol, a NAD+ precursor (NR as opposed to NMN), Vitamin K2 and Vitamin D.

Although NMN looks very interesting, I'm waiting for more clinical data to emerge on that before I incorporate it into my protocol.

Metformin is also something I've looked at personally.

I haven't incorporated it yet, but it is something I'm seriously looking at myself.

My fasting glucose levels are always spot on and I have great insulin sensitivity as is, so I have to weigh out the risk:reward of me using it.

Related

Read the original:

David Sinclair Supplements For Anti-Aging - What He Takes & Why

Decades of research have shown that calorie restriction extends lifespan and delays morbidity in many small, short-lived species: yeast, spiders, and various fish and rodents. In humans, though, the benefits of calorie restriction are still unproven, and probably less straightforward. And how calorie restriction slows the aging process is still not well understood. The interesting thing about calorie restriction is that we used to think the body was in some way slowing down, maybe in the number of heartbeats or production of free radicals, says professor of genetics David Sinclair. But it turns out thats wrong.When were calorie restricting, what were really doing is telling the body that now is not the time to go forth and multiply. Its time to conserve your resources, repair things better, fight free radicals, and repair broken DNA.

Sinclair believes that a compound found in all living cells, nicotinamide adenine dinucleotide (NAD), could be used to mimic these effects in humans without the starvation or decreased reproductive capacity associated with calorie restriction; his human trials of a therapy that could increase NAD levels are due to begin this month. Meanwhile, a similar compound is already being marketed as a supplement by a health start-up with several distinguished scientists (including three Harvard faculty members) on its advisory boardeven though theres still no evidence that the substance works.

Sinclairs approach is based on a broad view that links diseases of age such as cancer, diabetes, Alzheimers, and heart failure to common cellular processes. His lab aims to understand these processes and then use that understanding to develop medical therapies.

Underlying the wide-ranging benefits of calorie restriction, Sinclair explains, are sirtuinsa group of seven genes that appear to be very important in regulating the aging process. These longevity-gene pathways are turned on by changes in lifestyle such as exercise and calorie restriction, he says. They control a variety of protective processestheres hundreds of things that they do, and we still dont know everything. But they protect the chromosomes, they protect stem cells from being lost, they protect cells from senescing. Sirtuins can be activated by a lack of amino acids or of sugar, or through an increase in NAD. (The compounds level in the body declines with age.)

Earlier this year, research from Sinclairs lab showed that feeding mice nicotinamide mononucleotide (NMN)a related, precursor compound that the body converts into NADmay slow aging in the animals, mimicking the effects of calorie restriction. We get the same effects as exercise or dieting, he says. The mice are leaner, have more energy. They can run further on a treadmill. That research continues, and is poised to be tested in humans: the first stage of the trials of NMN that he was preparing to begin in August at a Harvard-affiliated hospital will test for NAD increases in the blood; after that, he plans to study NMNs efficacy in treating diseases. Sinclair has been taking the compound himself for about a year. Hes reticent about that, to avoid sounding like a kook, but claims his lipid profile has improved dramatically and he feels generally less fatiguedthough he admits this is not scientific.

There is a cautionary note to sound, says Jeffrey Flier, Walker professor of medicine and former dean of Harvard Medical School (HMS). The NAD precursor already on the market as a dietary supplement, nicotinamide riboside (NR), is sold by New York-based Elysium Health, founded by MIT biologist Leonard Guarente, Ph.D. 79, who played a central role in establishing the link between sirtuins and aging, and was Sinclairs doctoral adviser. The company doesnt make any specific claims about aging prevention (legally, it cant); instead, it promotes its product as the one daily supplement your cells need. Flier has criticized the company for using the names of the highly credentialed scientists on its advisory board (featured prominently on its website) to market an unproven product: Elysium is selling pills [without] evidence that they actually work in humans at all, he says, echoing the strongly worded Boston Globeop-ed he wrote earlier this year condemning the companys marketing scheme.

Sinclair, who co-directs the Glenn Center for the Biology of Aging at HMS, is not linked to Elysiumhis clinical trials go squarely down the traditional medical route, rather than through the loosely regulated supplement industry. Thats the contrast, he says. Im taking a pharmaceutical approach, FDA approval. Still, whatever animal research portends about the potential of NAD (and however alluring the promise of a cure for aging), the history of pharmaceutical development suggests its much too soon to expect any benefits for humans. Often molecules may be helpful to animals in a limited set of studies, but then are not shown to be helpful in humans, Flier warns. There are many, many, many examples of that.

Read the original here:

David Sinclairs anti-aging science | Harvard Magazine

Maxwatt, I don't see any mention in the Daily Mail article of +/- 13 years for Sinclair's age as you wrote. Sinclair, 47, said his pre NMN biological age was estimated to be 58 and after taking NMN for 3 months had an estimate of 32 years old. Is Sinclair lying about his estimated biological age as you suggest? It is possible, but I doubt it.

You quoted the daily mail as: with resveratrol at age "45 in 2015 and [he] still had a biological age of 58 according to what he recently revealed in an interview. Before he began taking 500 mg of NMN, he said his blood work showed that his biological age was that of a 58 year old but after the NMN, it had reversed to 32.

"

I subtracted 45 from 58 to get 13, and 32 from 45 to get 13. Hence +/- 13.

I know one of Sinclair's former postdoc students. He might ask for us what Sinclair was using for a test.

In the meantime Rapamycin looks more promising, but I am not ruling out NMN or dasatinib and quercetin, or a host of other molecules as being potentially beneficial. We need more data.

FWIW, for what its worth, I took one of those "age tests" and scored 14 years younger than my birth year. I'd been taking resveratrol for years. Tried NR with no noticeable effect. And this proves nothing.

Edited by maxwatt, 01 May 2017 - 03:28 AM.

See the original post here:

David Sinclair's biological age was 58 after taking 1000 mg ...

Lifespanis entertaining and fast-paceda whirlwind tour of the recent past and a near future that will see 90 become the new 70. In a succession of colorfully titled chapters (The Demented Pianist, A Better Pill to Swallow), Sinclair and LaPlante weave a masterful narrative of how we arrived at this crucial inflection point., Nature Journal

Sinclairs work on slowing the aging process, and even reversing some aspects of it, could lead to the most significant set of medical breakthroughs since the discovery of antibiotics nearly a century ago., Sydney Morning Herald

"In this insightful and provocative book that asks questions about how we age, and whether humans can overcome decay and degeneration, Sinclair grapples with some of the most fundamental questions around the science of aging. The result is an elegant and exciting book that deserves to be read broadly and deeply." -- Siddhartha Mukherjee, Pulitzer Prizewinning and #1 New York Times bestselling author

There are few books that have ever made me think about science in a fundamentally new way. David Sinclairs book did that for me on aging. This is a book that anyone who ages must read. -- Leroy Hood, PhD, professor at the California Institute of Technology, inventor, entrepreneur, member of all three US National Academies, and co-author of Code of Codes

If you ever wondered how we age, if we can slow or even reverse aging, and if we can live a healthy 100 plus years, then David Sinclairs new bookLifespan, which reads like a detective novel, will guide you through the science and the practical strategies to make your health span equal your lifespan, and make your lifespan long and vibrant. -- Mark Hyman, MD, director of the Cleveland Clinic Center for Functional Medicine and #1 New York Times bestselling author

This is the most visionary book about aging I have ever read.Seize the dayand seize this book! -- Dean Ornish, MD, founder and president of the Preventative Medicine Research Institute and New York Times bestselling author of UnDo It!

In Lifespan, David Sinclair eloquently tells us the secret everyone wants to know: how to live longer and age slower. Boldly weaving cutting-edge science with fascinating bits of history, sociology, and morality, Sinclair convinces us that it is not only possible to live beyond one hundred years, it is inevitable that we will be able to one day do so. If you are someone who wants to know how to beat aging, Lifespan is a must-read. -- William W. Li, MD, New York Times bestselling author of Eat to Beat Disease

For years, the aging field has been about vitamins, juicebars, and snake oil. Now, in a seminal book, Harvard Professor David Sinclair has changed the landscape: he has combined precise science, practical translation, and autobiography to produce a rare book that is insightful, inspiring, and informative. He has translated a wealth of molecular detail into a program that we can all use to live longer and healthier. This is part of the ongoing revolution in aging and chronic disease, and there is no one who is better suited to write such an authoritative book than David Sinclair. For anyone interested in understanding the aging process, living longer, and avoiding the diseases of aging, this is the book to read. -- Dale Bredesen, MD, New York Times bestselling author of The End of Alzheimer's

A visionary book from one of the most masterful longevity scientists of our time. Lifespan empowers us to change our health today while revealing a potential future when we live younger for longer. -- Sara Gottfried, MD, New York Times bestselling author of The Hormone Cure

Prepare to have your mind blown. You are holding in your hands the precious results of decades of work, as shared by Dr. David Sinclair, the rock star of aging and human longevity. -- Dave Asprey, founder and CEO of Bulletproof and New York Times bestselling author of The Bulletproof Diet

See the article here:

Lifespan: Why We Age_and Why We Don't Have To: David A ...

If you watched any of David Sinclair videos you probably noticed that he looks younger than he actually is. When I saw the video it made me think that this guy must be doing something that works for him. I did some research, and that brought me to his Joe Rogan podcast, where he explains exactly what he is doing to stay young.

I would highly suggest that you go watch the video as he gives out a massive amount of valuable information.

I will first give you an overview of all the things he does and then later try to explain how everything comes together

List of things David Sincalir consumes or does

Sirtuins are genes which protect all organisms from deterioration and disease. NMN and Resveratrol are molecules which essentially mimic the effects of the sirtuin genes.

NMN also boosts NAD levels (which sirtuins need to function)

Nicotinamide mononucleotide is a nucleotide derived from ribose and nicotinamide. Like nicotinamide riboside, NMN is a derivative of niacin, and humans have enzymes that can use NMN to generate nicotinamide adenine dinucleotide.

Formula: C11H15N2O8PMolar mass: 334.2192 g/mol

Resveratrol is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi. Sources of resveratrol in food include the skin of grapes, blueberries, raspberries, mulberries, and peanuts.

Molar mass: 228.25 g/molFormula: C14H12O3Solubility in water: 0.03 g/LMelting point: 261 to 263 C (502 to 505 F; 534 to 536 K)Appearance: white powder with; slight yellow castSolubility in DMSO: 16 g/L

Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. It is not associated with weight gain. It is taken by mouth.

Molar mass: 129.1636 g/molFormula: C4H11N5Excretion: Urine (90%)Trade name: Glucophage, otherBioavailability: 5060%Elimination half-life: 48.7 hours

There are 3 pathways related to aging:

Intermittent fasting is an umbrella term for various eating diet plans that cycle between a period of fasting and non-fasting over a defined period. Intermittent fasting is under preliminary research to assess if it can produce weight loss comparable to long-term calorie restriction.

The main idea is that you ideally skip a meal or two, therefore putting your body in a state of starvation which triggers different processes in the body, which are proved to have a broad variety of benefits, some of them include anti ageing benefits.

David recommends performing exercise regularly. He recommends running and doing resistance training.

David especially recommends exposing your body to temperature extremes which force your body to kick start protective mechanisms. He recommends doing a hot sauna immediately followed by cold water submersion.

See the article here:

David Sinclair supplements and protocol explained NMN ...