Category Archives: BioEngineering

The research report demonstrates vital and necessary market information on the Global Cosmetic Grade Lanolin Alcohol Market from 2021 to 2027. The most recent research from MarketsandResearch.biz includes information on the industrys current environment in various areas and actual data and market projections. The study also provides sales and demand statistics for the Cosmetic Grade Lanolin Alcohol market in multiple sectors and geographies. The report examines future potential and market circumstances for 2021-2027, rendering insights and updates on the global markets connected segments Cosmetic Grade Lanolin Alcohol.

The examination includes new rivals identified in the global market study of Cosmetic Grade Lanolin Alcohol. Business pictures, geographical presence, product portfolio, and current advances are all taken into account while analysing company profiles. It displays critical metrics and manufacturer asserts and may be a valuable source of assistance for businesses and organizations.

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It provides a comprehensive analysis of Cosmetic Grade Lanolin Alcohol market segments according to type:

Bleached Lanolin Alcohol, Conventional Lanolin Alcohol

It provides detailed research of the Cosmetic Grade Lanolin Alcohol market segments based on application:

Topical Skin Preparation, Cosmetics, Other

The study includes the following key market industry vendors:

Dishman, Weleda, Deutsche Lanolin Gesellschaft, Zhejiang Garden Biochemical, NK Ingredients, Nippon Fine Chemical, Heyang Suntech Bioengineering

The report emphasizes the regional sector analysis:

North America (United States, Canada and Mexico), Europe (Germany, France, United Kingdom, Russia, Italy, and Rest of Europe), Asia-Pacific (China, Japan, Korea, India, Southeast Asia, and Australia), South America (Brazil, Argentina, Colombia, and Rest of South America), Middle East & Africa (Saudi Arabia, UAE, Egypt, South Africa, and Rest of Middle East & Africa)

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The following market parameters were investigated in the study:

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Global Cosmetic Grade Lanolin Alcohol Market to Experience Significant Growth during the Forecast Period 2021-2027 The Oxford Spokesman - The Oxford...

ST. LOUIS Just as there often exists an urban-rural divide in political and environmental landscapes, urban and rural education systems share the common issue of being under-resourced, especially for science education.

Kristine Callis-Duehl, the Sally and Derick Driemeyer director of education research and outreach at the Donald Danforth Plant Science Center, and her collaborators at the Jackie Joyner-Kersee Foundation and University of Illinois Extension were awarded a three-year $685,000 grant from the U.S. Department of Agriculture to create a synergistic partnership between urban and rural communities in southern Illinois to establish a cross-regional curriculum that introduces bioengineering and plant monitoring technology to middle school aged youth in summer programs.

Young people at the Jackie Joyner-Kersee Foundation in East St. Louis, Illinois, and at the U of I Extension program in Waterloo, Illinois, will monitor corn growth in both regions by using in-demand technology including drones and a microclimate field monitoring system developed by Danforth Center scientist Nadia Shakoor.

By growing and comparing sweet corn, GMO commodity corn and non-GMO commodity corn, students will see firsthand how bioengineering improves plant health and crop yield.

By conducting joint fieldwork and presenting their ideas at a mini-conference, urban and rural youth will establish a collaboration that generates culturally mindful activities, as well as authentic data that can help shed light on the impact of climate change on corn harvests.

This collaboration will allow rural students to experience FarmBot robotics at work in smaller, urban plots and allow urban students to experience the use of drones used in precision agriculture on larger, rural farms.

Ultimately, through this informal authentic research experience, participants will help develop a culturally informed curriculum that can be launched nationwide to establish a network of urban-rural authentic research hubs for non-formal summer programs.

Young people participating in the project will gain an understanding of gene editing and hands-on experience using robotics to plant corn, as well as experience using drone and microclimate monitoring systems to assess corn growth and the microclimate, Callis-Duehl said.

It will also provide technological training, and exposure to data analysis to prepare them for the future, as big data analysis has become increasingly critical in agricultural science.

Youth also will gain leadership experience by providing feedback on the curriculum so that it evolves and by teaching the youth the partner program how to use the agricultural technology unique to their urban or rural research area.

Co-project directors include Lisa Walsh, Danforth Plant Science Center; Mark Fryer, Jackie Joyner-Kersee Foundation; and Amy Cope, U of I Extension.

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Collaboration aims to shrink the urban-rural divide - Agri-News

Researchers at the University of Texas at Dallas have developed a sensor that could detect a COVID-19 infection from your breath.

The portable, reusable breath test device, designed to provide results in less than 30 seconds, is being developed by Dallas-based SOTECH Health, which licensed the sensor technology developed by Dr. Shalini Prasad, department head and professor of bioengineering in the Erik Jonsson School of Engineering and Computer Science.

The device detects chemical markers of the bodys response to the virus.

It is not a diagnostic test for COVID, instead would be used as a screening tool and followed up with diagnostic testing, like a molecular PCR test.

The latest news from around North Texas.

"This test is revolutionary and paradigm shifting primarily because it is looking for human body's response or host response to the coronavirus," said Prasad.

SOTECH'S founding CEO Craig Micklich says the device could be used as a screening tool at places like large entertainment venues, airlines and ballparks.

"The value of the device is actually the high throughput of finding negative individuals, to push them through, to be able to get on airlines get in venues, any kind of venue," said Micklich.

SOTECH has already applied for FDA emergency authorization now it waits to see if the COVID-19 breath analyzer will become the next weapon in ending the pandemic.

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Rapid Breath Test for COVID-19 Developed in Dallas - NBC 5 Dallas-Fort Worth

image:Justin Schaal, PhD, assistant professor of research pathology at the Keck School of Medicine of USC view more

Credit: USC photo/ Ricardo Carrasco III

Somewhere along the long and winding road of evolution, our ancestors lost the ability to produce a small but mighty group of molecules called theta-defensins that help fight bacterial infections.

More than seven million years later, researchers at the Keck School of Medicine of USC are creating new-and-improved versions of these molecules as a potential way to treat antibiotic resistant superbugs.

The research, just published in Scientific Reports, was led by Justin Schaal, PhD,an assistant professor of research pathology at the Keck School of Medicine. The paper describes the development of a new, bio-inspired molecule that is highly effective in clearing bacterial infections in an animal model. Importantly, the molecule does not act as an antibiotic, but rather as an immune stimulant, representing a new way to treat life-threatening antibiotic resistant infections.

The need for alternatives to antibiotics

Since their introduction more than 70 years ago, antibiotics have been the standard of care for bacterial infections. Despite dozens of varieties, almost all work by killing bacteria directly or by blocking their ability to proliferate.

This is the root cause of antibiotic resistance, Schaal said. Bacteria have an immense ability to evolve rapidly, which gives them power to overcome direct-acting antibiotic molecules.

Over the past two decades, an increasing number of bacteria have become resistant to all but the most powerful antibiotics. Several groups of such superbugs exist, including Carbapenem-resistant Enterobacteriaceae (CRE). CRE, which include certain strains ofE. coliandKlebsiella pneumoniae, are resistant to the class of antibiotics known as carbapenemsa last resort option for many patients with persistent infections. According to the Centers for Disease Control and Prevention, in the U.S. alone, CRE superbugs represent an increasing fraction of the more than 140,000 deadly or life-threatening infections caused by species of Enterobacteriaceae.

To address this urgent threat to human health, the National Institutes of Health (NIH) challenged researchers to find new strategies to combat antibiotic resistant bacteria. Building on pioneering research on theta-defensins led by Michael Selsted, MD, PhD, chair and professor of pathology, Schaal and his colleagues got to work.

Bioengineering molecules to work like theta-defensins

Using as inspiration RTD-1, a naturally occurring theta-defensin found in old-world monkeys such as baboons and rhesus monkeys, the researchers bioengineered similar molecules and screened them for their ability to fight Klebsiella infections in a mouse model. The most potent peptide they created, a highly stable cyclic peptide called MTD12813, is 10 times more efficient than RTD-1 in clearing infections.

While more work is needed to determine exactly how MTD12813 works, the researchers know it activates the immune systemspecifically cells called macrophages and neutrophils that engulf and destroy pathogens. The peptide also modulates the immune response, reducing poorly regulated inflammation that often occurs when the body fights a bacterial infection.

We call this peptide a host-directed anti-infective because rather than kill the bacteria directly like traditional antibiotics, it stimulates the hostusto fight the infection, Schaal said.

Through a licensing agreement with USC, the technology will now be developed further in partnership withOryn Therapeutics.

Based on this and related research conducted at USC, Oryn is developing a novel class of macrocyclic peptides as therapeutics for unmet needs in autoimmune and inflammatory diseases, infectious diseases, and cancer. We are quite optimistic about the prospects for turning the important scientific advances reported in this publication into successful treatments for increasingly dangerous bacterial infections, said Robert Erwin, Oryns Chief Executive Officer.

Selsted said the timing for the development of this technology is right, given current concerns that the next pandemic may be bacterial in nature.

This new discovery of how to stimulate host clearance of bacteria is really timely, he said.

About the study

The title of the paper is A host-directed macrocyclic peptide therapeutic for MDR gram-negative bacterial infections. Additional authors are Yoshihiro Eriguchi, Dat Q. Tran, Patti A. Tran, Chase Hawes, Anthony E. Cabebe, Kaitlyn Pike, Katie Trinh, and Andr J. Ouellette, all from the Keck School of Medicine of USC.

The work was supported by grants from the National Institutes of Allergy and Infectious Diseases (RO1 AI22931, R01 AI125141), the National Institute of Dental and Craniofacial Research (R01DE021341), the Southern California Clinical and Translational Science Institute (UL1 TR000130 ), and the National Cancer Institute (P30 CA014089).

About Keck School of Medicine

Founded in 1885,theKeck School of Medicine of USCis one of the nations leading medical institutions, known forinnovative patient care, scientific discovery, education and community service. Medical and graduate students work closely with world-renowned faculty and receive hands-on training in one of the nations most diverse communities. They participate in cutting-edge research as they develop into tomorrows health leaders. With 1200 resident physicians across 70 specialty and subspecialty programs, the Keck School is the largest educator of physicians practicing in Southern California.

Scientific Reports

Experimental study

Animals

A host-directed macrocyclic peptide therapeutic for MDR gram-negative bacterial infections

6-Dec-2021

Selsted is a co-founder and Chief Scientific Officer of Oryn Therapeutics, LLC (Oryn). He is an equity holder but receives no income from Oryn. Tran is the Scientific Director of Oryn and is an equity holder. Ouellette is an equity holder in Oryn but receives no income. Oryn has licensed technology described in this publication from the University of Southern California and the relationship between Oryn and USC is disclosed to and approved by all parties. All other authors declare no competing interests.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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Boosting the body's response to infections with a bio-inspired peptide - EurekAlert

Clinical stage oncology company Prescient Therapeutics (ASX: PTX) has made plans to advance and accelerate its proprietary OmniCAR platform after unveiling two high-profile additions to its scientific advisory board.

In a statement to the market, the oncology company said it had appointed physician-scientist, Dr Marco Davila from the Moffitt Cancer Center and bioengineering expert Professor Andrew Tsourkas from the University of Pennsylvania, effective immediately.

The dual appointments are expected to bring unsurpassed expertise to Prescients ongoing development work on CAR-T therapies and binder protein engineering.

The company explained the rationale behind the move by stating that Dr Davila and Professor Tsourkas would bring deep complementary expertise to its operations and would compliment an existing team of highly credentialed personnel on the scientific board.

Currently, the broader team is comprised of CAR-T expert Professor Phil Darcy, hematologist and CAR-T researcher Professor H. Miles Prince and brain cancer specialist and cell therapy researcher Professor Don ORourke.

As a highly experienced clinical developer of CAR-T, Dr Davila is currently regarded as a leading figure in the field and is often invited to address global oncology conferences.

Dr Davila currently works at the Department of Blood and Marrow Transplantation at the Moffitt Cancer Center one of the largest cancer centres in the US treating patients with hematologic malignancies with various cell therapies.

Dr Davilas current research includes pre-clinical development and clinical translation of gene-engineered cell therapies, including CAR-T therapies, for patients with hematologic and solid tumour malignancies.

Moreover, Dr Davilas research has received widespread acclaim including generous grants and awards from the American Society of Hematology, Damon Runyon Cancer Research Foundation, the American Society of Clinical Oncology and the American Society for Clinical Investigation, respectively.

From my clinical experience with CAR-T therapies, as well as their pre-clinical development, I have seen both the early success of this revolutionary therapy in B cell malignancies and also the challenges in translating it to other cancers, said Dr Davila.

I am excited by the capabilities of OmniCAR to overcome many of these obstacles and bring gene-engineered cell therapies to many more patients. I am delighted to be appointed to Prescients SAB to help guide the development of OmniCAR, he added.

According to Prescient Therapeutics, OmniCAR is a universal immune receptor platform enabling controllable T-cell activity and multi-antigen targeting with a single cell product.

The company says it is the first of its kind: the first universal immune receptor allowing post-translational covalent loading of binders to T-cells.

As well as the addition of Dr Davila to its scientific board to help advance OmniCAR, Prescient is also bolstering its ranks from the University of Pennsylvania and an original co-founder of the technology.

Professor Tsourkas is a co-inventor of the patents developed at Penn and licensed by Prescient to form OmniCAR.

OmniCAR is based on technology first licensed from Penn as well as the so-called SpyTag/SpyCatcher binding system licensed from Oxford University. Given OmniCARs development path and close collaboration with Penns researchers, Prescient acquired the services of Professor Tsourkas as an organic fit.

Professor Tsourkas particular expertise in the conjugation of proteins is especially relevant to the development of OmniCARs binders, which involves incorporating SpyTag into antibodies and other antigen-binding molecules, the company said.

It has been wonderful to see the rapid progress of development of OmniCAR since Prescient licensed the underlying patent from Penn last year, said Professor Tsourkas.

The rapid, covalent nature of OmniCARs binding confers many unique capabilities and advantages over conventional CAR-T approaches. I look forward to assisting Prescient in the development of OmniCAR and its associated binders to address a variety of different cancers, Professor Tsourkas added.

Over the next 12 months, Prescient expects to expand the cohort read-out for its PTX-100 drug, as well as complete enrolment in the expansion cohort by Q3 2022. Prescient is confident of announcing several further value-adding milestones for each OmniCAR program throughout 2022.

In addition, Prescient has confirmed it expects to receive results for its PTX-200 Ph1b AML trial early next year with several cell therapy enhancements expected to come out of stealth mode in the first half of 2022.

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Prescient Therapeutics bolsters scientific advisory board with CAR-T and bioengineering experts - Small Caps

ST. LOUIS, MO, November 18, 2021 Just as there often exists an urban-rural divide in political and environmental landscapes, urban and rural education systems share the common issue of being under-resourced, especially for science education. As climate change looms over rural agricultural communities, urban heat islands could serve as critical partners for anticipating the future of economically important crops. Kristine Callis Duehl, PhD, the Sally and Derick Driemeyer Director of Education Research and Outreach at the Donald Danforth Plant Science Center and her collaborators at the Jackie Joyner Kersee Foundation and University of Illinois Extension were awarded a three year, $685,000 grant from United States Department of Agriculture to create a synergistic partnership between urban and rural communities in Southern IL to establish a cross-regional curriculum that introduces bioengineering and plant monitoring technology to middle school aged youth in summer programs.

Young people at the Jackie Joyner-Kersee Foundation in East St. Louis, IL and at the Illinois Extension program in Waterloo, IL will monitor corn growth in both regions by using in-demand technology including drones and a microclimate field monitoring system developed by Danforth Center scientist Nadia Shakoor, PhD. By growing and comparing sweet corn, GMO commodity corn, and non-GMO commodity corn, students will see first-hand how bioengineering improves plant health and crop yield. By conducting joint fieldwork and presenting their ideas at a mini-conference, urban and rural youth will establish a collaboration that generates culturally mindful activities as well as authentic data that can help shed light on the impact of climate change on corn harvests. This collaboration will allow rural students to experience FarmBot robotics at work in smaller, urban plots and allow urban students to experience the use of drones used in precision agriculture on larger, rural farms. Ultimately, through this informal authentic research experience, participants will help develop a culturally informed curriculum that can be launched nationwide to establish a network of urban-rural authentic research hubs for non-formal summer programs.

Young people participating in the project will gain an understanding of gene editing and hands-on experience using robotics to plant corn, as well as experience using drone and microclimate monitoring systems to assess corn growth and the microclimate, said Callis-Duehl. It will also provide technological training, and exposure to data analysis to prepare them for the future, as big data analysis has become increasingly critical in agricultural science.

Youth will also gain leadership experience by providing feedback on curriculum so that it evolves and by teaching the youth the partner program how to use the agricultural technology unique to their research area (urban or rural).

Co-Project Directors include Lisa Walsh, Danforth Plant Science Center, Mark Fryer, Jackie Joyner Kersee Foundation and Amy Cope, University of Illinois Extension.

About the Donald Danforth Plant Science CenterFounded in 1998, the Donald Danforth Plant Science Center is a not-for-profit research institute with a mission to improve the human condition through plant science. Research, education, and outreach aim to have impact at the nexus of food security and the environment and position the St. Louis region as a world center for plant science. The Centers work is funded through competitive grants from many sources, including the National Science Foundation, National Institutes of Health, U.S. Department of Energy, U.S. Agency for International Development, U.S. Department of Agriculture and the Bill & Melinda Gates Foundation. Follow us on Twitter at @DanforthCenter.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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Collaboration aims to shrink the urban-rural divide and address the impact of climate change through student research network - EurekAlert