Category Archives: Anti-Aging Medicine

Posted on March 27, 2017, 6 a.m. in Cardio-Vascular Diagnostics

More than half of family doctors in Canada are still using manual devices, a dated technology that often leads to misdiagnosis.

A study by researchers at the University of Montreal Hospital Research Centre (CRCHUM) reports that over half of the Canadian family doctors are still making use of manual devices to measure blood pressure, which is a dated technology. Using a manual device to measure blood pressure often leads to misdiagnosis. Approximately 20% of those receiving treatment for hypertension don't actually have it and do not need medication.

Automatic electronic devices, called oscillometric devices, are available and are recommended by the Guidelines of the Canadian Hypertension Education Program (CHEP) as preferable to manual measurement.

However, in the spring of 2016, the team that conducted the survey among the Canadian family doctors found that 52% of the 769 who responded stated that they made use of a manual tensiometer to measure patients' blood pressure, and only 43% used an automatic device.

The lead author of the study, Janusz Kaczorowski, is a medical sociologist, a CRCHUM researcher, and a professor in the Department of Family and Emergency Medicine.

Manual measurement is acceptable if it is done properly, but that is not always the case. Kaczorowski stated that clinicians should use automatic devices because they are more precise and take several measurements. Automated measurement has an advantage because it eliminates white-coat syndrome, which is an artificially high blood pressure reading that is a result of being in a doctor's office.

To take blood pressure properly, a 12- to 15-minute period is required with the patient being left alone in a room while the measurement is taken. That is difficult because the average visit to a family doctor lasts only 10 minutes.

Blood pressure is the pressure that the blood exerts on the walls of arteries. Measured in an artery in the arm, blood pressure has two measurements: systolic as the heart contracts and diastolic as the heart relaxes. Normal pressure has the systolic pressure at below 140 mmHg and the diastolic pressure at below 90 mmHg. Above those numbers, a person is said to have high blood pressure or hypertension.

In Canada, one of every five adults suffers from hypertension, which is the greatest global risk factor for disability and death. Healthcare costs due to hypertension were evaluated at over $13 billion in 2010. Kaczorowski says that if blood pressure was measured incorrectly, there are considerable financial implications as well as possible side effects, which could be avoided.

The CHEP Guidelines state that modification of health-related behaviors is an efficient way of treating and preventing high blood pressure and reducing the cardiovascular disease risk. It is possible to lower one's blood pressure with a healthy diet, reduced intake of sodium, regular physical activity, moderate consumption of alcohol, tobacco product avoidance, and stress management.

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Is it Really High Blood Pressure? - Anti Aging News

Fort Lauderdale, FL Life Extension has partnered with Insilico Medicine to introduce Ageless Cell, the first supplement in its GEROPROTECT line to promote healthy aging by inhibiting cellular senescence.

Cellular senescence is a natural part of the aging process where cells no longer function optimally, affecting organ function, cellular metabolism, and the inflammation response. The accumulation of these senescent cells contributes to the process of aging. The Ageless Cell supplements inhibit the effects of cellular senescence by acting as geroprotectors, or interventions aimed to increase longevity and impede the onset of age-related diseases by targeting and inhibiting senescence-inducing pathways and inhibiting the development of senescent cells.

The partnership with Insilico Medicine allowed researchers to use deep learning algorithms to comb through hundreds of studies and thousands of data points a process that could have taken decades to identify four key anti-aging nutrients: N-Acetyl-L-Cysteine (NAC), myricetin, gamma-tocotrienol, and EGCG. These compounds target pathways that are known to contribute to or protect against the development of senescent cells.

Specifically, NAC upregulates signaling pathways that protect cells against oxidative stress, which promotes cellular senescence. It also reduces pathways that promote inflammation. Myricetin regulates a family of stress-responsive signaling molecules known to regulate aging in many tissues. It also promotes cell differentiation and self-repair. Gamma tocotrienol modulates the mevalonate pathway that controls cholesterol production, cancer promotion, and bone formation. And EGCG regulates the Wnt pathway that determines the fate of developing cells and also prevents sugar-induced damage to tissues, helping to suppress their pro-aging effects.

Clinical aging studies are extremely difficult, if not impossible, to perform at this time. Our collaboration with Insilico Medicine has allowed us to develop geroprotective formulations by using artificial intelligence to study very large data sets, said Andrew G. Swick, Ph.D., senior vice president of product development and scientific affairs for Life Extension.

Scientists found these four nutrients have various complementary and reinforcing properties to influence key anti-aging pathways and combat aging factors by modulating specific biological pathways. By rejuvenating near-senescent cells and encouraging the bodys healthy process for dealing with senescent cells, Ageless Cell turns back the clock at the cellular level, said Michael A. Smith, M.D., senior health scientist for Life Extension.

Alex Zhavoronkov, Ph.D., CEO of Insilico Medicine said, Together, these four natural compounds represent the beginning of the future anti-aging cocktails identified using artificial intelligence under expert human supervision.

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Life Extension and Insilico Medicine Use Artificial Intelligence to Develop Ageless Cell - WholeFoods Magazine

Cromwell Schubarth TechFlash Editor Silicon Valley Business Journal Silicon Valley Business Journal It's focused on extending human health span, initially focused on diseases of aging. The big idea is that its drugs have been given to animals and those animals are surviving 25 percent to 30 percent longer. Importantly, they're surviving with shiny ...

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Cromwell Schubarth TechFlash Editor Silicon Valley Business Journal - Silicon Valley Business Journal

"Our publicity will show how what has become known as the 'Riobe Method' produces such results as abundant energy, strong sex drives, normal weight and significant protection from diseases such as cancer," he said.

According to Tim Allen, Vice President of Public Relations at TransMedia who'll be point person on the account, "Dr. Riobe addresses what so many patients complain about, but are not receiving effective treatments for, including such chronic conditions as fatigue, poor sleep and overweight.

"We plan to publicize how these common problems led Dr. Riobe to set out to find better alternatives and to learn methods that evaluate and treat root causes rather than mask symptoms. This calling led her to study Traditional Chinese Medicine and Holistic/Alternative Medicine includingBio-identical Hormone management."

About Dr. Riobe

Dr. Riobe completed her undergraduate studies at Columbia University/Columbia College in New York City where she grew up. She obtained her medical degree at NY Medical College and completed her residency in Obstetrics and Gynecology at Medical College of Pennsylvania and the University of South Carolina.

There she learned conventional medical practices which she practiced following her graduation and board certification in OB/GYN.

"During this time she became frustrated with what she saw as a 'cookie-cutter' approach to medicine and decided to incorporate alternative forms of medicine," Madden said.

"She found much better results when she combined traditional methods with time-tested Chinese medicine, which she incorporated into her practice and that will be the central theme of our PR campaign," he added.

Dr. Riobe's practice is located in Stuart, Florida where she treats patients while raising two children and maintaining remarkable personal fitness. She is an author and speaker at health and medical conferences nationwide. One of her books is titled "The Answer to Cancer."

Media contact Tim Allen 561-750-9800 x2220; tim@transmediagroup.com.

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/transmedia-group-to-represent-integrative-medicine-expert-and-author-mylaine-riobe-md--her-practice-combines-modern-functional-and-ancient-chinese-medicines-to-protect-against-diseases-such-as-cancer-300429426.html

SOURCE TransMedia Group

http://transmediagroup.com

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TransMedia Group To Represent Integrative Medicine Expert and Author Mylaine Riobe, MD. Her Practice Combines ... - PR Newswire (press release)

Were living longer these days, but that hasnt stopped newer branches of medicine from trying to enhance and further extend our lifespans.

Researchers in longevity medicine and biogerontology are studying drugs and compounds that can prevent and reverse aging on the cellular level.

Over the past few years, public interest in longevity issues has grown, but that interest is mostly in health-extending therapies, not simply life-extending therapies. Most people are interested in living longer, but only if they can also be healthier longer, Sonia Arrison, author of 100 Plus: How the Coming Age of Longevity Will Change Everything, From Careers and Relationships to Family and Faith, and founder of Singularity University in California, told Healthline.

While many people are focused on lifestyle changes, the addition of drugs rapamycin and metformin are two that Arrison mentioned gives humans more options to extend their lives as well as the quality of their lives.

Compared with preventative drugs such as statins to avoid having a heart attack, anti-aging drugs fight multiple diseases at once instead of focusing on one ailment, Arrison added.

A person who goes by the name Reason, a technologist and author on FightAging.org, which highlights health- and longevity-enhancing medical technologies, told Healthline that the drugs are targeting a wide range of age-related ailments and diseases.

All age-related diseases are age-related because they are caused by the processes of aging, which is to say an accumulation of damage in cells and tissues, Reason wrote in an email.

Read more: Botox may have long-lasting, anti-aging effects

The field of geroprotection involves understanding cell senescence, which is when cells stop dividing.

When senescent cells no longer divide, they stop functioning, so organ health deteriorates. Cell senescence also causes the release of proinflammatory cytokines, which damage tissues.

This arena involves the use of geroprotectors, which are compounds that can stop or reverse cellular aging, and senolytics, which are compounds that can pinpoint and destroy senescent cells.

This is why researchers are looking into geroprotectors and senolytics, which requires long spans of time to understand.

In essence, todays researchers may never see the outcomes of the research theyve started because it can take decades to study. Nevertheless, scientists continue to try to understand these compounds and how they can alter our cells.

Researchers are also looking into our cells telomeres, which are short segments of DNA in our chromosomes that protect cells from wear and tear that comes with aging. As cells divide, they can shorten and no longer protect the chromosome or cell.

Lengthening them is the focus of recent research. Last year, a BGRF study was able to lengthen human telomeres.

A recent report in the journal Cell detailed how peptides were able to boost the life span of mice. The study examined how cell therapy could reverse poor age-related kidney function, fur loss, and frailty in mice.

Scientists are looking into whether or not the approach can also prolong the life span of mice. Human safety studies are in the works.

Reason said there are two schools of thought when exploring extending life through genetic pathways.

One approach is to alter cellular metabolism and make cells age more slowly, but the work is difficult and expensive. The other is to fix old tissue because we understand how it compares with young tissue.

No one yet fully understands everything these [older] cells do to us, but the fastest way to find out is to get rid of them, and we know that doing that in mice extends life and reverts aspects of aging, Reason explained.

Either you slow down the damage, or you repair the damage. Aging is damage. It is in the how of achieving one of those goals that all the complexity starts up, Reason added.

Read more: Beer may keep your DNA young, study says

The Human Aging Genomic Resources (HAGR) website recently released DrugAge, a database of lifespan-extending drugs and compounds.

It includes 418 compounds that were recorded from studies on 27 different model organisms.

HAGR already operates the GenAge database of age and longevity-related genes in humans and model organisms. They also operate AnAge, which has aging and longevity records of more than 4,000 species, the GenDR database of genes associated with the life-extending effects of dietary restriction, and LongevityMap, which includes more than 2,000 human gene and genetic variations linked to longevity.

DrugAge incorporates earlier efforts by Biogerontology Research Foundation (BGRF) scientists, who produced Geroprotectors.org. Right now, its the largest database of its kind.

According to the research teams from BGRF and the University of Liverpool, pharmaceuticals have not targeted most age-related pathways. The research is only focused on a small number of pathways that are currently known.

The goal behind the database is to pave the way for discovery of new life span-extending and health span-extending compounds.

I am confident that it [DrugAge] will gain widespread use in the aging research community, and represents a significant milestone along the way to the coming paradigm shift in modern healthcare away from single disease treatment and toward geroprotective multi-disease prevention, Dmitry Kaminskiy, managing trustee of BGRF, said in a statement.

Franco Cortese, deputy director and trustee of BGRF, said in a statement the database will be extremely valuable for biogerontologists. The BGRF did not respond to Healthlines request for comment.

Already, researchers are using the data to identify trends and develop a better understanding of the comparative effects of geroprotectors on organisms.

Arrison is excited when she sees people teaming up globally to battle human disease and decline something that the DrugAge team is hoping to do with their database.

The more knowledge the health community can get, the better. The wonderful thing about the internet is that knowledge gets distributed faster, making the quest for cures that much quicker, Arrison added.

Read more: Study breaks down aging process, may lead to solutions

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New Drugs That Could Help Us Live Longer - Healthline

New York Times

Lacking EMTs, an Aging Maine Turns to Immigrants New York Times Now, thanks to an unusual program that is training immigrants to become emergency medical technicians, she is preparing to make better use of her medical background and, she hopes, work her way up to becoming a physician assistant if not, someday, ... and more »

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Lacking EMTs, an Aging Maine Turns to Immigrants - New York Times