Category Archives: Anti-Aging Medicine

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Stem cells collected from fat may have use in anti-aging treatments Science Daily Adult stem cells collected directly from human fat are more stable than other cells -- such as fibroblasts from the skin -- and have the potential for use in anti-aging treatments, according to researchers from the Perelman School of Medicine at the ... Stem cells from fat could be used in anti-aging treatments - UPI.comUPI.com all 2 news articles »

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Stem cells collected from fat may have use in anti-aging treatments - Science Daily

Chronological aging shows the natural life cycle of the cells as opposed to cells that have been unnaturally replicated multiple times or otherwise manipulated in a lab.

In order to preserve the cells in their natural state, Penn researchers developed a system to collect and store them without manipulating them, making them available for this study. They found stem cells collected directly from human fat -- called adipose-derived stem cells (ASCs) -- can make more proteins than originally thought. This gives them the ability to replicate and maintain their stability, a finding that held true in cells collected from patients of all ages.

Our study shows these cells are very robust, even when they are collected from older patients, said Ivona Percec, MD, director of Basic Science Research in the Center for Human Appearance and the studys lead author. It also shows these cells can be potentially used safely in the future, because they require minimal manipulation and maintenance.

Stem cells are currently used in a variety of anti-aging treatments and are commonly collected from a variety of tissues. But Percecs team specifically found ASCs to be more stable than other cells, a finding that can potentially open the door to new therapies for the prevention and treatment of aging-related diseases.

Unlike other adult human stem cells, the rate at which these ASCs multiply stays consistent with age, Percec said.

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Stem Cell therapy is future of anti-ageing - Bangalore Mirror

Question: What is the latest skin tightening technology?

Answer: Ultherapy is a treatment based on ultrasound technology. It works by using ultrasound-guided technology to actually view the underlying tissue that is being treated.

We are able to reach below the dermal layer, sending ultrasound energy penetrating deeper to the fibro-muscular tissue, promoting collagen production. If you have weakened collagen in the deeper connective tissue, it can cause the skin to become prone to gravitational forces and begins to stretch, sag and shift downward a process we call aging.

This is where Ultherapy plays a role. It is FDA approved for the forehead, face and neck.

The Ultherapy treatment begins with marking the area on the face to be treated. This is the same target area that is addressed in cosmetic surgery for skin tightening.

Once the skin is marked for treatment, a mild sedative is given. A full face treatment can take anywhere from 45 to 60 minutes. You may return to normal activities and can experience flushing or redness that should resolve within a few hours.

The regenerative process is initiated at the first treatment, however, results may take up to six months since you are relying on the bodys own healing process to repair and rebuild your skins foundation.

For more information, visitwww.MDBeautyLabs.com, or call (561) 655-6325 to schedule a complimentary consultation.

Daniela Dadurian, M.D., specializes in anti-aging medicine and is an expert in non-surgical body-contouring techniques. She received her medical degree from the University of Miami School of Medicine and has traveled the world researching the safest and latest technologies on the market.

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MD Beauty Labs Medical Spa and Wellness Center

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Excellent weapon in war on aging - Palm Beach Post

Human fat could be the answer to more effective anti-aging treatments, researchers at the University of Pennsylvania say.

The researchers at Penn's Perelman School of Medicine said Friday they discovered adult stem cells from fat are more stable than other stem cells, such as those taken from skin, that are currently used in a variety of anti-aging treatments.

The cells from fat, called adipose-derived stem cells (ASCs), have the ability to make more protein that originally thought, therefore allowing them to replicate and maintain their stability.

Our study shows these cells are very robust, even when they are collected from older patients, said lead author Ivona Percec, MD.

The discovery "can potentially open the door" for new treatments and therapies to address aging-related diseases.

The researchers noted that ASCs are not currently approved for direct use by the Food and Drug Administration. They said more research is needed before potential implementation of their finding.

The finding was published in the February edition of the "Stem Cells" medical journal.

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How fat could lead to more effective anti-aging treatments - PhillyVoice.com

Zi Ran looks into the exciting biology surrounding telomeres and their potential impact

The thread of never-ending life has always been a part of the canvas of myths and religion subsequently morphed seamlessly into everyday culture. Every religion and culture has their own telling of the tale. The Abrahamic religions have heaven, the Norse gods ate Iunns apples, the Greek gods ate ambrosia and drank nectar, the Taoists sought the elixir of life, and the medieval alchemists sought the philosophers stone. Though these ancient symbols may have been metaphoric, with current technology eternal youth feels to be almost within our grasp. With organisations like Google Calico, A4M (American Academy of Anti-Aging Medicine), Human Longevity Inc and sponsors like Peter Thiel and Mark Zuckerberg, it seems as though humanity may finally taste that fountain of life.

To find immortality, one must understand mortality. Cells seemingly repair and divide without end, but they exhibit signs of ageing as well. The crux of the issue lies in the inherent structure of our genetic material, DNA. Human DNA is linear, so there must be two ends to the double helix. Every time DNA is replicated, information on the ends of the strands are lost. With increasing divisions, more and more information is lost to the point where the cell is no longer able to function cells senescence. Cells with this kind of DNA structure must have an extra layer of molecular protection which ensure many healthy divisions before their eventual death. These protective elements are called telomeres. Telomere research has been a hot topic within the anti-ageing community, as its length is directly correlated to longevity. These DNA aglets are extra pieces of DNA which cap on to the ends of the double helix strand and tightly wraps itself together to protect the genetic material both from chemical and mechanical damage. However, this method is not fool-proof. Telomeres also run out, and with time all cells eventually die.

The miracle of the fountain of life, if it exists at all, can only be found in the moment of conception. In embryos, the DNA is refreshed, and old used telomeres are extended. Embryonic cells are a rare type of cells which express telomerase, the only protein capable of extending the length of telomeres. These little molecular machines use RNA as a template to extend the depleted telomeres, elongating the lifespan of the cell. Telomerases are also expressed in some stem cells, which supply the body with red blood cells and repair large damages. As attractive as telomerases sound as a solution to age, their over-expression can also become a problem. Many tumours and cancer types use telomerase as a tool to extend their lifespan indefinitely, outliving their healthy counterparts and taking over the body. To fine-tune the activity of this protein such that humans achieve eternal life while escaping the potential over-proliferation of cells is something that has yet to be achieved.

The most important breakthrough of 2016?

Telomeres, all in all, may only be one piece of the longevity biochemical puzzle. Many other biological processes are affected by age, although the precise mechanisms remain shrouded in mystery. Mitochondria become less efficient, transport to and from the nucleus becomes much less regulated, proteins are misshapen more often, and the DNA racks up too many mutations to efficiently repair them. It looks as though humanity still has so much to learn in terms of mortality that the seemingly tiny gap to eternal life may actually be a journey of a thousand miles.

Once we understand the essentials of life, will eternity still be attractive? The underlying basis of all living things is maintenance of a dynamic equilibrium, meaning that balance is maintained through constant life and death. The confusion of age for life has been recorded since the time of the ancient Greeks. When Eos mistakenly asked on Tithonus behalf for immortality and not eternal youth, what she really obtained from Zeus was eternal torture. The ancient Homeric hymns only remember Tithonus as a withered old man with no strength to even sit up, certainly an anecdote to keep us grounded in our search

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Telomeres nature's anti-ageing scheme - Varsity Online

Even the most well-informed and highly skeptical skin-care users (i.e. dermatologists) are buying into these buzzy treatments. Here, we've rounded up the best dermatologist-approved anti-aging tips and tricks to try for your best-looking skin yet.

Sometimes buzz, hype, and a Instagram blitz happens for a reasonbecause said treatments are efficacious, effective, and safe. These are three the pros stand by.

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Double-cleansing. Washing your face twicewith an oil-based cleanser followed by a water-based oneis a trend. But for Whitney Bowe, a dermatologist in New York City, its just part of her anti-aging regimen. Double-cleansing can preserve collagen, she says. Sure, that sounds like a tall order, but Bowe uses a DIY oil cleanser to dissolve makeup easily without the rubbing that can age your skin. She even takes off her mascara with the oil so she doesnt have to tug on her lashestheyve gotten thinner with age, so they fall out more easily. Her recipe: two tablespoons of olive oil stirred into eight ounces of aloe vera water. She follows that with Cetaphil Gentle Skin Cleanser to finish the job.

Vampire facials. OK, doctors actually call them platelet-rich plasma injections, but youre probably more familiar with the Kardashian-popularized term. (In case you missed that episode: The treatment involves injecting extracts from a patients own blood back into her skin using tiny needles.) It seems bonkers/creepy, but injecting plasma-rich platelets, which are full of stem cells, could help build new collagen, says Marie Jhin, a dermatologist in San Francisco. And replacing collagen in your skin as you age is a continuous battle. She does the treatments on herself twice a year; Bowe does the same.

CoolSculpting. This device destroys fat cells with extreme coldin about an hour. The technique is called cryolipolysis, and it works best on small areas of fat, says Karyn Grossman, a dermatologist in Los Angeles. I was happy with my overall weight, but fat had accumulated around my upper back and one hip. Two cycles of CoolSculpting completely changed the way my dress fit for my sons bar mitzvah, she says.

If you remember only one thing from this story, remember this: Sunscreen is nonnegotiable. It helps prevent skin cancer, and people who wear it have 24 percent fewer signs of aging than those who dont, according to a study published in Annals of Internal Medicine . Dermatologists apply it every day, more than once, rain or shine. And they have a few things to say on the matter.

For sheer coverage: Too many sunscreens look obvious on skin of color. They dont blend in, or they make my skin look gray or purple, says Jeanine Downie, a dermatologistand an African-American womanin Montclair, New Jersey. Her solution: SkinMedica Total Defense + Repair Broad Spectrum SPF 34 Sunscreen . I wear it on my face, my neck, my ears, and the back of my hands every day, she says. Its very sheer, and I reapply it. For medium skin tones, Mona Gohara, a dermatologist in Danbury, Connecticut, who is Egyptian, says La Roche-Posay Anthelios SPF 30 soaks in very quickly and doesnt leave a chalky cast.

For lasting protection: Bowe and Gohara carry around the Colorescience Loose Mineral Foundation SPF 20 Powder Brush for touch-ups over makeup. It contains iron oxides, and a recent study showed that sunscreens with iron oxides prevent melasma better than formulas without them, says Gohara. Its really (really) important to know, however, that powders are supplements to, not replacements for, traditional sunscreen lotions and creams. Ellen Marmur, a dermatologist in New York City and a premelanoma survivor, applies a tinted formula with SPF, like Chanel Vitalumire Moisture-Rich Radiance Sunscreen Fluid Makeup Broad Spectrum SPF 15 , each morningand then reapplies it over her makeup before going outside throughout the day. I do a lot of skin-cancer surgeries on the tops of the eyebrows, between the eyes, and around the nostrils, so Im careful to cover those spots, she says.

For the whole package: Every single dermatologist we talked to layers sunscreen over an antioxidant serum or cream. Thats key for neutralizing the free radicals from sunlight, pollution, and even heat that can slip through sunscreen, damage collagen, and set off pigment production in skin, says Bowe, who likes Olay Total Effects 7 in One Anti-Aging Moisturizer with vitamin E and green tea extract for her sensitive skin. I wear it at night, tooif you sleep in moisturizer, you wake up with more hydrated and plump skin. And that means fine lines are less noticeable the next day.

PHOTOGRAPHED BY CLAIRE BRAND

Snoop around a docs bathroom (nosy) and youll find three unlikely standbys.

Hydroquinone. This skin lightener is banned in Europe, and studies have shown it is carcinogenic in rats when ingested. But most American dermatologists are confident about its safety when its used topicallyso confident that they rely on it to fade their own dark spots. It can brighten even the most intractable pigmentation and works faster than anything else (in as little as two months). Jhin applies a prescription Obagi Nu-Derm product twice a day; Alicia Barba, a dermatologist in Miami, uses Melamix Skin Lightener & Blending Crme Hydroquinone USP 4% at night for two to four weeks three times a year to treat her melasma.

Compression socks. Theyre not exactly sexy, but Gohara gets four or five pairs at the drugstore at the beginning of pants season and wears them daily to prevent the varicose veins caused by standing all day.

More dermatologist-approved anti-aging tips:

Even dermatologists skin acts upthe difference is they know how to get it back in shape, pronto. For mild eczema flare-ups, Jessica Wu, a dermatologist in Los Angeles, heads to the health aisle for an Australian bee-pollen extract called propolis. Its anti-inflammatory and antibacterial and has been shown to help skin heal itself, she says. If thats not enough, then Ill use prescription cortisone.

Then there are the smart choices dermatologists make that have nothing to do with creams or lotions or unattractive hosiery.

They don't rub their eyes. The skin there will darken if youre a chronic rubber, says Nada Elbuluk, a dermatologist in New York City, who recommends putting a cool compress on the eyes whenever you feel the urge to rub. Grossman goes as far as sleeping in bendy glasses, called Swissflex glasses. Uncomfortable? Maybe. But they keep her sleeping on her back, which prevents her skin from creasing against her pillow (and eventually wrinkling).

They go to bed. Ive become neurotic about prioritizing sleep over an extra hour of iPad, says Gohara. When you dont sleep, your cortisol levels shoot up, which causes inflammation in the body. That can make skin conditions like acne and rosacea worse and, over time, lead to wrinkles.

They get physical. What I do with my body affects my skin almost as much as what I put on it, says Gohara. To that end, she does 20 to 30 minutes of high-intensity interval training every morning to enhance her circulation, reduce stress, and decrease the inflammation that causes aging.

Now, find out when it's time to call a dermatologist:

Vote for your favorite makeup, skin, hair, and body products by February 20, 2017, and you'll be entered for chances to win one of four awesome beauty prizes!

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Dermatologist-Approved Anti-Aging Tips to Try for Better Skin - Allure Magazine