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Minneapolis Heart Institute Foundation Receives $5 Million Charitable Gift to Accelerate Progress in World-Class Cardiovascular Prevention Research…

MHIF Establishes the Nolan Family Center for Cardiovascular Health to drive its commitment to changing the trajectory of heart disease

MINNEAPOLIS Aug. 3, 2020 The Minneapolis Heart Institute Foundation (MHIF), an internationally renowned cardiovascular research organization, announced today a $5 million charitable donation from the Stuart Nolan family to support cardiovascular disease prevention research and education that aims to change the trajectory of heart disease for future generations. In honor of the gift matching the largest donation ever made to the foundation MHIF is establishing the Nolan Family Center for Cardiovascular Health.

My personal connection to cardiovascular research started with the care and treatment I received more than 30 years ago at the Minneapolis Heart Institute, which continues to allow me to live a full life, said Stuart Nolan, a long-time supporter of MHIF. My children have reached the age at which I had my first heart attack, raising the importance of understanding genetic and other risk factors that affect their heart health and underscore the importance of this work to my family. I have great faith in Dr. Miedema and his team of dedicated MHIF researchers who have shown a sincere commitment to furthering research to define the prevention and management of cardiovascular risks that affect many families.

At a time when wellness and overall health is as important as ever, this gift will accelerate progress and innovation in research and education around how to prevent cardiovascular disease, which continues to be the number one cause of death for people around the world. This research will also address some of the challenges around health disparities by further defining and understanding risk factors, as well as identifying the best care pathways for addressing care in racial and ethnic minorities where heart disease outcomes are significantly worse than other populations.

Our commitment to impactful, cardiovascular disease prevention research isnt new, but this inspiring gift from the Nolan family will propel our efforts to change the paradigm from heart disease to optimal health, said Michael Miedema, MD, MPH, director of the Nolan Family Center for Cardiovascular Health at MHIF and director of cardiovascular prevention at the Minneapolis Heart Institute. The ultimate goals of cardiovascular prevention research are to identify the optimal methods to accurately assess cardiovascular risk, as well as determine the best interventions to stop the evolution to heart disease. The research is all about determining who to treat and how to treat them, which gives our patients the best chance to avoid the tragic heart attack or the unwanted bypass surgery.

Mr. Nolan formerly served as MHIFs chairman of the board and is the current chairman of Minneapolis-based StuartCo, a residential property management company that he founded in 1970. He has received recognition for his ongoing commitment to giving back to the community.

Dr. Miedemas leadership in the field of cardiovascular disease prevention includes serving on the executive review committee for the 2018 American College of Cardiology/American Heart Association (ACC/AHA) Cholesterol Guidelines and serving as a member of the 2019 ACC/AHA Committee for the Primary Prevention of Cardiovascular Disease. He also serves as an associate editor for the prevention section of ACC.org.

Over its 38-year history, MHIF has led groundbreaking research and education across a wide spectrum of prevention-related topics, including coronary artery calcium testing, blood pressure, cholesterol and statin use, nutrition and lifestyle behaviors, risk factors and screening for specific populations, premature heart disease and genetic disorders. New cutting-edge research planned for the Nolan Family Center for Cardiovascular Health will focus on risk prediction and optimal prevention therapies, including:

We are grateful to the Nolan family for a gift that drives the MHIF vision of creating a world without heart and vascular disease, said Kristine Fortman, PhD, MHIF CEO. This significant gift will accelerate our impact in preventive cardiovascular research, including supporting the infrastructure for the research, staff and fellows to lead an accelerated pace of clinical studies.

The Nolan family is creating a legacy in partnership with a respected research team, whose passion for discovery will advance our mission of achieving long and healthy lives for all without the burden of cardiovascular disease, said Scott Sharkey, MD, president and chief medical officer at MHIF. At this moment in our history, an unprecedented pandemic has emphasized the importance of a healthy lifestyle; we are thankful to be able to drive this important research that will benefit our patients and their families now and for generations to come.

About Minneapolis Heart Institute Foundation

The Minneapolis Heart Institute Foundation (MHIF) strives to create a world without heart and vascular disease. To achieve this bold vision, it is dedicated to improving the cardiovascular health of individuals and communities through innovative research and education.

Scientific Innovation and Research MHIF is a recognized leader across all specialties of heart and vascular research. Each year, MHIF leads more than 200 research studies with more than 2,200 patients and publishes more than 200 articles to share learnings from research. MHIF research has improved the standard of care for patients around the world, including through the development of protocols like Level One, which continues to significantly improve outcomes and survival for heart attack patients.

Education and Outreach MHIF provides more than 10,000 hours of education each year putting its research into practice to improve outcomes among health care providers. This commitment extends to patients and caregivers through a number of community health and education events to raise awareness of heart care and research, engaging individuals in their own health.

The Minneapolis Heart Institute Foundations work is funded by generous donors and sponsors and engages in cutting-edge research initiatives with its physician partners from the Minneapolis Heart Institute at Abbott Northwestern Hospital and at 38 community sites across Minnesota and western Wisconsin. For more information, please visit mplsheart.org.

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Transplant patient turns to art to raise money for charity which saved her life – Bishop’s Stortford Independent

A young Bishop's Stortford woman who suffers from a rare immune disorder has completed a challenge to paint every day for a month to raise money for the Anthony Nolan charity.

Michelle Peppiatt, 30, received a stem cell transplant last year after the organisation found her a matching donor and is now recovering at her home in Wallace Court where she has been shielding since before the coronavirus outbreak.

Art has proved a great outlet for Michelle in keeping her anxiety at bay and at the completion of her challenge yesterday (June 30) she had raised more than 700. "At the beginning of the month I decided to fundraise for Anthony Nolan, who save the lives of thousands with blood disorders. But I started to wonder how they were getting by during Covid-19 and it suddenly hit me that it could have been me and I might not have had my transplant so I decided to fundraise by taking art every day for the duration of June.

"Post transplant I really struggled to find things I was capable of doing due to the effects of the treatment and just stumbled across art and thought I would give it a go. I fell in love with it - it's been a great outlet for me."

Michelle's condition is known as Haemophagocytic lymphohistiocytosis (HLH), a rare immune disorder where the body reacts inappropriately to a trigger, usually an infection. There are two forms of HLH - primary which is a genetic type and secondary which is caused by a malignant blood cancer or acute infection/virus.

Michelle was diagnosed with lymphoma first and then the HLH was discovered. She said: "I had the treatment that is suggested for HLH which is eight weeks of chemotherapy and immune therapy. I relapsed three times after several rounds of chemotherapy immune therapy and biological therapies - my only chance at surviving was a stem cell transplant.

"The HLH had affected all my organs and muscles. But my medical team turned to Anthony Nolan to help. Anthony Nolan search every stem cell donor register in the world to find some one who is a perfect genetic match. I received my stem cell transplant in January 2019. I have long term effects of treatment and art helps me manage anxiety, pain, fatigue and isolation.

"I spent a number of weeks and months in isolation during treatment, due to infections and after the transplant. I'm adjusted to being sheilded and have learnt to keep myself occupied. I have had to find ways to manage my anxiety and general mental health."

Michelle describes her work as fluid art using acrylics and each day has picked a subject matter out of a pot. "Today was oceans and I made art based on the colours of the ocean. I've been painting every day, usually three paintings a day, and sell them via my Facebook page, but now we're at the end I'm looking to expand because they are still selling and I hope to reach more people," she said.

"And now that I have created a space for continuing after this I possibly will set it up as a business. "

She said the experience of lockdown "wasn't too bad as I have spent the last three and a half years in isolation" and discovering art had been a great help. "It has been incredibly therapeutic for me. It has no boundaries, it's very freeing."

On her Facebook posts, Michelle says: "At the start of this I did begin to wonder what I'd let myself in for. When I look at my paintings I've accomplished I feel something I haven't felt in a long time. Peace. A moment of mindfullness and connection!"

Michelle's remaining paintings will still be on sale until August 1. Visit @chelepep/freedomart on Facebook or her instagram page @chellepep for more details.

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The Fannie and John Hertz Foundation Announces 2020 Fellows – Newswise

Newswise The Fannie and John Hertz Foundation, a nonprofit organization dedicated to empowering the most promising innovators in science and technology, has announced the 2020 recipients of the Hertz Fellowship.

The Hertz Fellowship supports the research of PhD students who demonstrate the greatest potential to tackle the most urgent problems facing society. This years fellowships will fund 16 researchers whose goals range from developing drugs more quickly, cheaply, and effectively, to advancing artificial intelligence to creating a carbon-neutral future.

One of the most prestigious awards of its kind, the Hertz Fellowship supports five years of graduate research and the freedom to pursue innovative ideas, wherever they may lead. Hertz Fellows also receive lifelong professional support, including mentoring and networking within a connected, influential community of more than 1,200 leaders in science and technology, each of whom has been awarded the Hertz Fellowship since 1963.

The pursuits of our 2020 Hertz Fellows embody the type of bold, risk-taking research that the Hertz Foundation has supported for almost six decades, said Robbee Baker Kosak, president of the Fannie and John Hertz Foundation. By funding innovative thinkers and connecting visionary researchers across generations, geography, and disciplines, we create the conditions for our fellows to have an exponential impact on the most pressing problems facing our nation and world.

Selected through a rigorous process, including in-depth interviews with some of the nations top scientists, engineers, and mathematicians, the newest Hertz Fellows were selected from a pool of more than 800 applicants from 24 universities across the nation.

We strive to identify young researchers with the vision and drive to achieve the breakthroughs that are needed today in science and technology, said Philip Welkhoff, senior interviewer and member of the board of directors at the Hertz Foundation, as well as the malaria program director at the Bill & Melinda Gates Foundation. As a society, we benefit tremendously from empowering them with the freedom to leap into the unknown and explore the possibilities.

The 2020 class joins a community of fellows whose transformative research and daring innovation impact our lives every day. Hertz Fellows are developing a drug therapy to restore hearing, data-driven methods to detect cyber threats, technology to genetically eradicate invasive plant species, and immunotherapy to support universal organ transplants. Theyve uncovered contraband nuclear weapons, created hack-proof drones for the military, and proven the Big Bang theory of the origin of the universe.

Many Hertz Fellows are currently focusing their work on addressing the COVID-19 pandemic. Anna Bershteyn is co-principal investigator in a clinical trial to determine if the antimalarial drug hydroxychloroquine can prevent COVID-19 from developing in people whove been recently exposed to the virus. In work published in Nature, Cheri Ackerman and Cameron Myhrvold collaborated on the development of diagnostic technology that can simultaneously test 1,000 samples for 160 different viruses.

Over the foundations 57-year history of awarding fellowships, Hertz Fellows have established a remarkable track record of accomplishments. Their ranks include two Nobel laureates; two MacArthur Fellows; eight recipients of the Breakthrough Prize; and winners of the Turing Award, the Fields Medal, the National Medal of Technology, and the Wall Street Journal Technology Innovation Award. In addition, 43 are members of the National Academies of Sciences, Engineering, and Medicine, and 12 have been included in Forbes magazines 30 under 30 list. Hertz Fellows have founded more than 200 companies and hold more than 3,000 patents.

Introducing the 2020 Hertz Fellows

Fellows are listed along with their graduate institution and field of interest.

Alexander (Sasha) Alabugin (California Institute of Technology; Chemistry) Alexander Alabugin aspires to advance energy science by characterizing and controlling elementary transactions of small molecules, protons, photons, and electrons. His goal is to unravel inorganic reaction mechanisms with techniques ranging from x-ray absorption to electron resonance and Mssbauer spectroscopy. A senior in chemistry at Massachusetts Institute of Technology, Alexander is also a fellow of the National Science Foundation.

Daine Danielson (University of Chicago; Physics) An Eckhardt Graduate Scholar in the Enrico Fermi Institute at the University of Chicago, Daine Danielson envisions a world in which a global network of neutrino-based nuclear monitoring technologies is used to root out clandestine weapons manufacturing, reducing the threat of nuclear terrorism and war. His research explores the phenomenology of fundamental particles and fields, developing novel applications toward nuclear security and nonproliferation, and deepening our understanding of the natural world. Cofounder and chief architect of the medical education platform Whitekoat, Inc., he holds a bachelors in computational physics with a minor in mathematics from the University of California, Davis.

Alyssa Dayan (University of California, Berkeley; Computer Science) Alyssa Dayan hopes to further our knowledge about intelligence and cognition while enabling smarter new technologies that can help the world. A machine learning research scientist on the research and development team at Uber Advanced Technologies Group, where she works on simulation and prediction for autonomous vehicles, she received a bachelors in mathematics with computer science from Massachusetts Institute of Technology in 2018.

Marisa Gaetz (Massachusetts Institute of Technology; Mathematics) Exploring the numerous connections between physics and representation theory, Marisa Gaetz conducts research with potential applications for quantum mechanics. A senior at Massachusetts Institute of Technology, she is graduating with a bachelors degree in mathematics and a minor in philosophy. Outside of her research, Marisa works to improve diversity and inclusivity within the mathematics community. A leader of the MIT Prison Education Initiative, she also focuses on using education and technology to improve the criminal justice system and reduce mass incarceration.

Jakob Grzesik (Stanford University; Electrical Engineering, Physics) By connecting engineering design and fundamental physics, Jakob Grzesik hopes to create new quantum-based technologies to address problems in energy, computation, and communication. A senior completing dual degrees in electrical engineering and mathematics at Rice University, Jakob aims to apply his growing expertise in optical properties of nanoscale materials to develop novel photonic technologies for applications in quantum computation, communication, and energy.

Hannah Lawrence (Massachusetts Institute of Technology; Computer Science) Hannah Lawrence is interested in developing theoretical foundations for new algorithms at the interface of machine learning, data science, and signal processing, with potential impact in drug development and other applications. She is particularly interested in broadening our understanding of how structure and scientifically informed priors can be incorporated into learning problems and frameworks. Currently a research analyst at the Center for Computational Mathematics at the Flatiron Institute, Hannah is a 2019 graduate of Yale University with a bachelors in applied mathematics and computer science.

Isaac Metcalf (Rice University; Materials Science) Isaac Metcalf hopes his research can help push the nation and world toward a carbon-neutral future. A senior at Massachusetts Institute of Technology, Isaac is graduating with dual degrees in physics and materials science. He will join the Materials Physics for Energy Management group at Rice University, where he plans to focus his research on increasing the efficiency and stability of two-dimensional perovskite photovoltaics.

Nolan Peard (Stanford University; Physics) Nolan Peard is interested in light-matter interactions and their applications in chemistry and quantum optics. He is particularly interested in the potential of optical techniques to control quantum states of molecules and their interactions, enabling fundamental understanding of chemistry that may be used to create materials and molecules with new capabilities. He is graduating with dual degrees in physics and music from Massachusetts Institute of Technology.

Maya Sankar (Stanford University; Mathematics) Maya Sankar is interested in researching combinatorics and graph theory, particularly studying extremal problems and their ties to theoretical computer science. A senior at Massachusetts Institute of Technology, she is graduating with dual degrees in mathematics and computer science and a minor in music.

Jillian Silbert (Harvard University; Quantitative Biology and Bioengineering) Combining computational and experimental methodologies in her biological research, Jillian Silbert believes that interdisciplinary work is the key to furthering scientific knowledge and crafting creative solutions to environmental and health issues. She plans to study interactions within the bacterial communities and applications of microbiology research to current environmental and biomedical issues. Jillian graduated magna cum laude from Princeton University in 2018, with a bachelors degree in molecular biology and a minor in quantitative and computational biology. She studied as a Fulbright Scholar at the National Center of Biotechnology in Madrid.

Vikram Sundar (Massachusetts Institute of Technology; Computational and Systems Biology) By tackling difficult questions in computational structural biology, Vikram Sundar hopes to help scientists develop drugs more quickly, cheaply, and effectively. He plans to combine his knowledge of physics and machine learning to tackle problems ranging from understanding protein/ligand binding for drug discovery to designing proteins with specific functions. Vikram received a bachelors degree in mathematics and a masters degree in physics from Harvard University in 2018 and a masters degree in chemistry from the University of Cambridge, where he was a Churchill Scholar, in 2019. He is currently an AI resident at Google.

Constantine Tzouanas (Massachusetts Institute of Technology; Biological Engineering) Constantine Tzouanass long-term goal is to engineer biological systems to address pressing needs, from organ transplants to environmentally responsible chemical production. A National Science Foundation Graduate Research Fellow in the Harvard-MIT Health Sciences and Technology program, he is pursuing a PhD in medical engineering and medical physics with a concentration in biological engineering. He graduated summa cum laude from Rice University in 2019 with a bachelors degree in bioengineering and a minor in neuroscience.

Nico Valdes Meller (Massachusetts Institute of Technology; Physics) Nico Valdes Meller hopes that a more profound understanding of networks can help us be better prepared for the technological revolutions to come. Aiming to work at the interface of theoretical physics and its applications by studying field theory, gravitation, and quantum information, Nico will pursue his PhD after completing a one-year masters program at Perimeter Scholars International. He received a bachelors degree in physics from the University of Chile.

Sophie Walton (Stanford University; Biophysics) By exploring the limits and capabilities of biological systems and such fundamental processes as evolution, Sophie Walton hopes to further the applications of biophysics research. A senior at California Institute of Technology, she is graduating with a bachelors degree in bioengineering.

Maxwell Wang (Carnegie Mellon University/University of Pittsburgh; Machine Learning and Neuroscience) An MD/PhD student at the University of Pittsburgh and Carnegie Mellon University, Maxwell Wang is conducting research with the goal of understanding how brain networks change during neuro-interventions, such as deep brain stimulation, and to link these changes to end-points such as symptom improvement and adverse side-effect profiles. A graduate of Washington University in St. Louis with a bachelors degree in electrical engineering, he began taking math courses at the University of Illinois, Urbana-Champaign, when he was in fifth grade and published his first research paper while a young teenager.

Katherine Xiang (Harvard University; Physics) The role of physics in biology motivates Katherine Xiang to understand the natural world better, particularly in energy flow and transport in biological systems. A senior at Johns Hopkins University, she is graduating with a bachelors degree in physics, biophysics, and mathematics.

About the Fannie and John Hertz Foundation

The Fannie and John Hertz Foundation identifies the nations most promising innovators in science and technology, and empowers them to pursue solutions to the worlds toughest challenges. Launched in 1963, the Hertz Fellowship is the most exclusive fellowship program in the United States, fueling more than 1,200 leaders, disruptors, and creators who apply their remarkable talent where it's needed mostfrom improving human health to protecting the health of the planet. Hertz Fellows hold 3,000+ patents, have founded 200+ companies, and have received 200+ major national and international awards, including two Nobel Prizes, eight Breakthrough Prizes, the National Medal of Technology, the Fields Medal, and the Turing Award. Learn more at https://HertzFoundation.org.

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Outsmarting cancer: Innovative treatments and diagnostics offer new hope – Stanford Medical Center Report

Researchers at Stanford Medicine are thinking up new ways to tackle one of the world's most daunting diseases: cancer.

My colleague Krista Conger and I tag-teamed an article in the new issue of Stanford Medicine magazine that features some of the latest and most innovative tactics Stanford researchers are pursuing to detect cancer earlier and stop the disease in its tracks.

More than a dozen scientists told us about the impressive research that's helping patients survive what was once a death sentence.

"In biomedicine, we're faced all the time with intractable problems, and cancer is one of these problems that is very difficult to solve," biochemistry professorSteven Artandi, MD, PhD, the Laurie Kraus Lacob Director of theStanford Cancer Institute, told us. "Often, these problems are solved by thinking about them in a completely different perspective, and that's the kind of attitude and approach that we foster at Stanford."

In this feature, we highlighted a handful of new diagnostics Stanford researchers are developing, such as smart toilets to detect signs of cancer from stool and urine. We also described several treatments that are in clinical trials or under development.

In the lab of of Garry Nolan, PhD, for instance, scientists are using a powerful and complex cell analysis technique called multiplexed ion beam imaging to detect and measure levels of certain molecules, including those that flag cancer. The research could reveal a new, deeper understanding of cancer at a molecular level.

Among the treatments featured in the article is one some people call a "cancer vaccine," a breakthrough from the lab of oncologist Ronald Levy, MD, who has dedicated his career to fighting blood cancers. Unlike a traditional vaccination, which prevents disease before it starts, this one bolsters the body's ability to battle disease that already has a foothold.

Levy injects tumors with an agent that boosts activity of immune cells called T cells, after the T cells have infiltrated the cancer and begun to fight it.

Levy and his colleagues have shown that their strategy could eliminate established human tumors in mice not only at the site of injection, but also at distant sites throughout the body.

Image by Keith Negley

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Who will be next to join Flyers immortality? – South Philly Review

Two years ago, Eric Lindross No. 88 was raised to the rafters of the Wells Fargo Center as the dynamic center and former hockey child prodigy became the sixth Flyer to have his number retired.

Some, including maybe Lindros himself, thought the day might never come, as his well-documented disputes with former general manager Bobby Clarke at times seemed irreparable.

Bygones eventually became bygones and Lindros joined Bernie Parent, Mark Howe, Barry Ashbee, Bill Barber and Clarke himself in Flyers immortality.

Whos next?

Should there be a next?

You could argue that the Flyers six retired numbers sounds just about right for a franchise that is 52 years old and has won two Stanley Cups. In fact, the Los Angeles Kings and Dallas Stars (formerly Minnesota North Stars), which each entered the league at the same time the Flyers did, will each have six retired numbers once Sergei Zubovs 56 jersey gets raised next season in the Lone Star State.

The St. Louis Blues, also an original expansion team, will have eight retired numbers when Chris Prongers No. 44 is raised next year. The Pittsburgh Pittsburgh, another 1967 expansion team, somehow have only two retired numbers despite five Stanley Cups. Obviously, Nos. 87 and 71 will be added when Sidney Crosby and Evgeni Malkin are finished being Flyers nightmares.

But should those ratios matter? The Buffalo Sabres have seven retired numbers, and the Vancouver Canucks have six despite never winning the Cup and having a slightly shorter history than Philly.

A decent case could be made for several former Flyers, and maybe a few current players, to be the next guy.

Before we dive deep, a few honorable mentions should be named before reaching the top five. Those would be John LeClair, Simon Gagne, Tim Kerr, Reggie Leach and Eric Desjardins. All were great players and are in the Flyers Hall of Fame with the exception of Gagne, whose name should be called soon.

Here are the five with the best odds of being the next Flyer to have his number retired, in alphabetical order.

Claude Giroux If his time with the Flyers ended today, Giroux falls short. But he still holds his destiny in his own hands. Think about if the Flyers do win a Stanley Cup in the next few years and Giroux is the captain who ends a 40-something-year drought the way Mark Messier ended 54 years of torture in New York.

Giroux is currently third in games played in team history, second in assists and fourth in points. By the time he retires, he could be the only player besides Bobby Clarke to finish with 1,000 games and 1,000 points in a Flyers uniform. Bonus points if he ends his career here.

Ron Hextall This is another guy whose story hasnt quite reached completion. Holding the most wins in franchise history (240), Hextall is regarded as the second-best Flyers goalie behind Parent and won the Vezina and Conn Smythe trophies during his time here while taking the Flyers to the Stanley Cup Finals twice.

The second phase of his hockey career was his stint as general manager of the team just a few years ago. Drafting players such as Travis Konecny, Ivan Provorov, Travis Sanheim, Oskar Lindblom, Nolan Patrick, Joel Farabee, Morgan Frost and Carter Hart have set the Flyers up for success. If the team wins a Stanley Cup soon, Hextalls fingerprints will be all over the blueprints.

Rick MacLeish The sun is getting pretty low for the Broad Street Bullies-era guys but MacLeish is still worth mentioning. MacLeish, who died in 2016 at 66, was best known for his performance during both postseasons in which the Flyers won the Stanley Cup, scoring 42 points in 34 games during those two runs. He played in 741 regular season games over a dozen years in Philadelphia and ranks sixth in goals (328) and fifth in points (697).

Perhaps overshadowed by other local heroes of that era, MacLeish never really got the appreciation he deserved. Its now been 36 years since he last played, which probably means the case is closed on MacLeish.

Brian Propp When you talk about stats, Propps jump off the page. In 11 years in Philly, Propp amassed 369 goals, 480 assists and 849 points and was a plus-299 during his time here.

Hes second only to Bill Barber in goals as a Flyer and is a top five in almost every major statistical category. More recently, Propp learned to walk again after recovering from a massive stroke in 2015 and remains a pillar in local philanthropy and a friendly face at Flyers alumni events.

If you need an inspirational hero, look no further.

Mark Recchi Years ago, Recchi might have been considered a long shot, as most of his success had come elsewhere, winning Cups in Pittsburgh, Carolina and Boston. But Recchi was inducted into the Hockey Hall of Fame in 2017 and played the largest chunk of his career in Philadelphia, which included two stints. Having played for seven NHL teams, Recchis only chance at number retirement is likely in Philadelphia, although only 627 of his 1,533 career points were collected here.

Recchis 123 points during the 1992-93 season remains a team record, and he followed it with 107 points the following year.

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Danvers health group offers alternative solution to surgery – Wicked Local North of Boston

Stem cell therapy: the next wave in regenerative medicine?

All it involved was a quick injection no different, really, than a flu shot.

A few weeks later, Bill Ambrose realized hed become significantly less reliant on taking Aleve for knee pain, and he was re-learning how to walk without shuffling his feet.

Surgery, it turned out, might not be necessary after all.

Last November, Ambrose scheduled knee surgery to alleviate discomfort in his knees caused by what orthopedic doctors called true bone-on-bone at the joint. But for one reason or another, he kept missing pre-surgery and the surgery never happened.

The next month, Ambrose met with Dr. Bill Nolan, of Cherry Street Health Group, to discuss advertising space in the Danvers Herald.

For the purpose of full disclosure, Ambrose is an employee of Gatehouse Media Company, and he works in the advertising department for Wicked Local, the local branch of GHM newspapers.

After Nolans ads ran inthe Jan. 5issue of the Herald, Ambrose said he reached out to Nolan again. This time, for himself.

Nolans practice offered a solution to his knee pain an alternative to knee surgery he had never considered before: stem cell therapy.

Essentially, the solutionCherry StreetHealth Group offered was an injection of amniotic fluid into Ambrose's knee joint. The stem cells and other growth factorsin the fluid would allow for the regeneration of the cartilage at the joint.

I became interested so I decided to go ahead with it, Ambrose said.

He brought in scans to show Nolan, who said, contrary to what orthopedic doctors had told him, he didnt have true bone on bone. There was still a small space between the bones.

I decided to have one leg done and my knee started getting much better, he said.

Satisfied with the results of the first injection, Ambrose decided to get his left knee done in April.

I still experience some pain in [the left knee], but I get up in the morning and theres very little pain at all, he said in an interview a few weeks following the appointment.

The stem cell option

In the U.S., there are three ways that stem cells are used, Nolan said. Theyre either taken from bone marrow, fat cells, or the amniotic membrane of a healthy c-section from a consenting woman.

When stem cellsare injected into the body,they're expected to increase space at the joint, rebuild cartilage, and ultimately, provide more stability in the joint. As many as 570 businesses across the country advertise some kind of stem cell therapy, according to a 2016 paper.

Stem cell therapy is not necessarily a new discovery, but it is relatively recent in the world of regenerative medicine.Stem cells were first used as much as century ago, first for eye procedures and as filler for the spinal cord, according to Regenexx, which claims to have pioneered orthopedic stem cell treatments in 2005.

Adult stem cells are retrieved directly from the patient, either frombone marrow or fat cells,and concentrated beforeits reinjectedinto the patient's site of pain.

In the case of amniotic fluid therapy,amniotic fluid, which contains stem cells and other growth factors, is injected into the site. These cellshave been shown to "expand extensively" and show "high renewal capacity,"according to research published in the National Library of Medicine.

We know that as you age, your stem cell count decreases,Nolan said, explaining the benefit of using cells from the amniotic membrane. We know that when we get it from the amniotic membrane, theres a large amount of stem cells that are present. From the amniotic membrane, there are no antibodies or antigens, so its safe for anyone to get.

At Cherry Street Health Group, theproduct usedis produced by General Surgical and distributed by RegenOMedix, according to Nolan.The product, which is called ReGen Anu RHEO, is American Tissue Bank approved and FDA cleared.

RHEO is marketed as "a human tissue allograft derived from placental tissue; amniotic membrane and amniotic fluid."Its a"powerful combination" of amniotic fluid and mesencymal stem cells, which are known to differentiate into a variety of cell types, according to RegenOMedix.It also contains growth factor proteins andis "rich" in other necessary components for tissue regeneration.

The product is non-steroidal and comes with no side effects, and the company says no adverse events have been recorded using the product.

Nolan said stem cell therapy has been offered as a treatmentat Cherry Street since 2016.

Across the U.S., there are as many as 56 businesses marketing some form of amniotic stem cellsto its consumers, according to the same paper.

At Rush University Medical Center in Chicago, for example, orthopedic surgeon Adam Yanke enrolled one of his patients into an experimental amniotic cell therapy treatment program. The woman, a 65-year-old suffering from osteoarthritis in both knees, told reporters the injections were "by far the most effective pain treatment" she had tried, and so farthat relief has lasted up to a year.

But while the use of amniotic fluid therapyas a regenerative medicine is becoming increasingly popular throughout the U.S.,the use of amniotic stemcellsdoesn't comewithout concern from some within the community.

Dr. Chris Centeno, who specializes in regenerative medicine andthe clinical use of adult stem cells, has blogged numerous times for Regenexx on the "scam" of using amniotic stem cells most recently in sharply worded post on May 22.

"Regrettably, we have an epidemic on our hands that began when sales reps began telling medical providers thattheir dead amniotic and cord tissues had loads of live cells on it," he wrote.

Nolan said he was familiar with Centeno's posts.

"A lot of the stem cell stuff is new," he said. "Some of the products out there ... They were doing testing on them and not finding cells."

Cherry Street Health Group has treatedabout 50patients with this form of regenerative medicine and had significant success, according to Nolan. Although Nolan owns the health group on Cherry Street in Danvers, the stem cell treatments are provided under the medical practice of Dr. Pat Scanlan.

Weve had really, really amazing success, Nolan said. Weve had over 95 percent success of all the patients weve had in the office. Its been a game changer from a practice standpoint.

The "worst thing" that could happen is there might not be any regeneration, he explained.

"You might get pain relief, but no regeneration," Nolan said. "But from what weve seen, there have been no negative side effects."

At Cherry Street, knees are the most commonly treated joints, followed by hips, shoulders and the lower back. The cervical spine is the least common.

"I hesitated on the surgery, and I'm gladI did," Ambrose said. "Even if[the stem cells]don't do any more than what they've done, its been well worth it."

Patients who do present with true bone on bone, however, are not candidates for this form of therapy, Nolan said.

The cost comparison

At Cherry Street Health Group, the cost of the injection comes toroughly $4,000 per knee, a cost that isn't covered by insurance. By comparison, health-care providers often charge insurers more than $18,000 for knee replacement surgeries in the Boston area, according to a report by the Blue Cross and Blue Shield Association.

The report, however, doesn't account for what the patient actually pays.

Nolan said when other factors of post-op are considered time off of work, rehabilitation time and cost the out-of-pocketcost for surgery compared to stem cell treatment is comparable.

"When you really boil it down, it can be the same or, in a lot of cases, a savings," he said.

Ambrose said it "boggles his mind" that more people don't choose this treatment over surgery.

"Why would you spend $40,000 on a car and not want to spend $4,000 on a knee?," he said."Its crazy. Yes, its out of pocket. So what? We buy a lot of stuff we dont need, and then for something like this, something that people, if they do it, theyll be glad they did it. Its just hard to convince them to do it."

In arecent report in STAT news, a health news start up of the Boston Globe, a study of orthopedic procedures in the U.S. suggested an estimated one-third of knee replacement surgeries are inappropriate. More than 640,000 of these surgeries are performed each year, making for a $10 billion dollar industry in knee surgery.

The study said that evidence isn't limited to just knee surgeries.

"There's a lot that needs to change when we look at health care in general,"Nolan said. "It's really no surprise that something like doing this regenerative medicine is going to take time for it to really take off."

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Danvers health group offers alternative solution to surgery - Wicked Local North of Boston

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