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Combination Therapy of Lung Cancer Using Layer-by-Layer Cisplatin Prod | DDDT – Dove Medical Press

Yuan Hong,1 Shaomin Che,2 Beina Hui,2 Xiaoli Wang,2 Xiaozhi Zhang,2 Hailin Ma2

1Department of Medical Imaging, The First Affiliated Hospital of Xian Jiaotong University, Xian, Shaanxi, Peoples Republic of China; 2Department of Oncology Radiotherapy, The First Affiliated Hospital of Xian Jiaotong University, Xian, Shaanxi, Peoples Republic of China

Correspondence: Hailin MaDepartment of Oncology Radiotherapy, The First Affiliated Hospital of Xian Jiaotong University, No. 277 Yanta Xi Road, Xian, Shaanxi 710061, Peoples Republic of ChinaEmail mahlxjtu@sohu.com

Purpose: Lung cancer remains the leading cancer-associated deaths worldwide. Cisplatin (CDDP) was used in combination with curcumin (CUR) for the treatment of non-small cell lung cancer. The aim of this study was to prepare and characterize CDDP prodrug and CUR co-encapsulated layer-by-layer nanoparticles (CDDP-PLGA/CUR LBL NPs) to induce cooperative response, maximize the therapeutic effect, overcome drug resistance, and reduce adverse side effects.Methods: CDDP prodrug (CDDP-PLGA) was synthesized. CDDP-PLGA/CUR LBL NPs were constructed and their physicochemical properties were investigated by particle-size analysis, zeta potential measurement, drug loading, drug entrapment efficiency, and in vitro drug release behavior. In vitro cytotoxicity against human lung adenocarcinoma cell line (A549 cells) was investigated, and in vivo anti-tumor efficiency of CDDP-PLGA/CUR LBL NPs was evaluated on mice bearing A549 cell xenografts.Results: CDDP-PLGA/CUR LBL NPs have a size of 179.6 6.7 nm, a zeta potential value of 29.9 3.2 mV, high drug entrapment efficiency of 85.6 3.9% (CDDP) and 82.1 2.8% (CUR). The drug release of LBL NPs exhibited a sustained behavior, which made it an ideal vehicle for drug delivery. Furthermore, CDDP-PLGA/CUR LBL NPs could significantly enhance in vitro cytotoxicity and in vivo antitumor effect against A549 cells and lung cancer animal model compared to the single drug-loaded LBL NPs and free drug groups.Conclusion: CDDP-PLGA/CUR LBL NPs were reported for the first time in the combination therapy of lung cancer. The results demonstrated that the CDDP-PLGA/CUR LBL NPs might be a novel promising system for the synergetic treatment of lung carcinoma.

Keywords: lung cancer, combination therapy, layer-by-layer, cisplatin prodrug, curcumin

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Combination Therapy of Lung Cancer Using Layer-by-Layer Cisplatin Prod | DDDT - Dove Medical Press

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Evergreen Medical Acupuncture is now offering its own supplement and herbal products, Dr. Ficks Functional Farmacy! – TippNews DAILY

EVERGREEN, Colo., June 9, 2020 (SEND2PRESS NEWSWIRE) Combining the use of Eastern and Western philosophy of Holistic Medicine, Dr. Christina Fick, of Evergreen Medical Acupuncture, has created a carefully selected offering of CGMP (certified good manufacturing practice), and organic certified supplements and herbal products that provide a well-balanced approach to healing.

Evergreen Medical Acupuncture, a locally owned and operated Colorado Business located in Evergreen, Colorado, has always offered the best of Eastern and Western Medicine to its customers, and is happy to announce the new online store for these offering, Dr. Ficks Functional Farmacy, at https://www.drchristinafick.com/functional-farmacy.

With a wide variety of hand-picked, quality herbal supplements with a focus on some of the best practices of Eastern Medicine, Dr. Ficks Functional Farmacy provides clients the ease of online information and recommendations, and the ability to order products from home. Products such as Phyto-Multiplex, a multi-vitamin + phytonutrient + trace mineral supplement, Premium Choline for brain, gut, and general health, and Nutra-Absorb for digestive support, are now ready for the online audience.

Dr. Ficks Functional Farmacy is also offering an exclusive cosmetic line, Skin for Life, and a selection of specialty luxury soaps, called My Soap Box. Skin for Lifes ingredient formulas are in a nutritional nano bio-emulsion sphere that delivers vitamins, minerals, and essential lipids to protect the skins immunity integrity, and the beautifully scented, exotic body and facial bar soaps of My Soap Box are a perfect way to provide an escape from the days stresses, or to provide a truly unique gift for someone dear to you.

We offer the best of Eastern and Western Medicine to our clients The Chinese now see the benefit of modern medicine, and how it can be applied to the practice of Traditional Chinese Medicine, stated Dr. Christina Fick. By combining the best of both worlds, we can achieve sustainable results for our clients using Acupuncture, Specialty Needle Techniques, and our custom-built Acupuncture Clinic. These herbal supplements and new products represent some of our best recommendations, and compliment these techniques, and are now available to clients with a mouse-click.

About Evergreen Medical Acupuncture, Dr. Ficks Functional Farmacy, and Dr. Christina Fick

Located in both Evergreen, Colorado, Evergreen Medical Acupuncture is locally owned and operated. The company and its employees live and work in Colorado, and also offer phone or video chat appointments for consultation to anyone in the nation. The acupuncturists on in the Clinic work closely under Dr. Fick, have been hand-selected and vetted, and go through rigorous ongoing training to provide highest standards of service and customer care.

Dr. Christina Fick is the owner and founder of Evergreen Medical Acupuncture, LLC, first opened in 2012. She holds a Doctorate in Acupuncture and Oriental Medicine, a Masters degree in Herbology, and is certified in Functional Medicine. She has worked globally in her specialized field, in hospitals both in China, and in New York.

For more information about Dr. Ficks Functional Farmacy, and Evergreen Medical Acupuncture, including details about their services and new custom built Acupuncture Clinic, please visit the company website: https://www.drchristinafick.com/, or call to book an appointment or learn more at 303-594-8348.

*PHOTO link for media: https://www.Send2Press.com/300dpi/20-0609s2p-evergreen-med-300dpi.jpg

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

News Source: Evergreen Medical Chiropractic and Acupuncture

To view the original post, visit: https://www.send2press.com/wire/evergreen-medical-acupuncture-is-now-offering-its-own-supplement-and-herbal-products-dr-ficks-functional-farmacy/.

This press release was issued by Send2Press Newswire on behalf of the news source, who is solely responsible for its accuracy. http://www.send2press.com.

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Evergreen Medical Acupuncture is now offering its own supplement and herbal products, Dr. Ficks Functional Farmacy! - TippNews DAILY

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Nanomedicine Market 2019 Break Down by Top Companies, Countries, Applications, Challenges, Opportunities and Forecast 2026 – Cole of Duty

A new market report by Market Research Intellect on the Nanomedicine Market has been released with reliable information and accurate forecasts for a better understanding of the current and future market scenarios. The report offers an in-depth analysis of the global market, including qualitative and quantitative insights, historical data, and estimated projections about the market size and share in the forecast period. The forecasts mentioned in the report have been acquired by using proven research assumptions and methodologies. Hence, this research study serves as an important depository of the information for every market landscape. The report is segmented on the basis of types, end-users, applications, and regional markets.

The research study includes the latest updates about the COVID-19 impact on the Nanomedicine sector. The outbreak has broadly influenced the global economic landscape. The report contains a complete breakdown of the current situation in the ever-evolving business sector and estimates the aftereffects of the outbreak on the overall economy.

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The report also emphasizes the initiatives undertaken by the companies operating in the market including product innovation, product launches, and technological development to help their organization offer more effective products in the market. It also studies notable business events, including corporate deals, mergers and acquisitions, joint ventures, partnerships, product launches, and brand promotions.

Leading Nanomedicine manufacturers/companies operating at both regional and global levels:

Sales and sales broken down by Product:

Sales and sales divided by Applications:

The report also inspects the financial standing of the leading companies, which includes gross profit, revenue generation, sales volume, sales revenue, manufacturing cost, individual growth rate, and other financial ratios.

The report also focuses on the global industry trends, development patterns of industries, governing factors, growth rate, and competitive analysis of the market, growth opportunities, challenges, investment strategies, and forecasts till 2026. The Nanomedicine Market was estimated at USD XX Million/Billion in 2016 and is estimated to reach USD XX Million/Billion by 2026, expanding at a rate of XX% over the forecast period. To calculate the market size, the report provides a thorough analysis of the market by accumulating, studying, and synthesizing primary and secondary data from multiple sources.

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The market is predicted to witness significant growth over the forecast period, owing to the growing consumer awareness about the benefits of Nanomedicine. The increase in disposable income across the key geographies has also impacted the market positively. Moreover, factors like urbanization, high population growth, and a growing middle-class population with higher disposable income are also forecasted to drive market growth.

According to the research report, one of the key challenges that might hinder the market growth is the presence of counter fit products. The market is witnessing the entry of a surging number of alternative products that use inferior ingredients.

Key factors influencing market growth:

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Thank you for reading this article. You can also get chapter-wise sections or region-wise report coverage for North America, Europe, Asia Pacific, Latin America, and Middle East & Africa.

To summarize, the Nanomedicine market report studies the contemporary market to forecast the growth prospects, challenges, opportunities, risks, threats, and the trends observed in the market that can either propel or curtail the growth rate of the industry. The market factors impacting the global sector also include provincial trade policies, international trade disputes, entry barriers, and other regulatory restrictions.

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Market Research Intellect provides syndicated and customized research reports to clients from various industries and organizations with the aim of delivering functional expertise. We provide reports for all industries including Energy, Technology, Manufacturing and Construction, Chemicals and Materials, Food and Beverage and more. These reports deliver an in-depth study of the market with industry analysis, market value for regions and countries and trends that are pertinent to the industry.

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Nanomedicine Market 2019 Break Down by Top Companies, Countries, Applications, Challenges, Opportunities and Forecast 2026 - Cole of Duty

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Nanomedicines Market will touch a new level in upcoming year with Top Key Players like Abbott, GE Healthcare, Johnson & Johnson, Merck, Pfizer,…

Nanomedicine is one of the applications of nanotechnology used in diagnosis, treatment, monitoring, and control of biological systems. Nanomedicine uses nanoscale manipulation of materials to improve medicine delivery. Thus, nanomedicine has facilitated the treatment against various diseases. Nanomedicine is in nascent stage, as several products are in the development phase. According to Nanobiotix (a nanomedicine company), in 2015, around 230 nanomedicine products were identified, which are either marked or are in the trial phase.

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This report covers Nanomedicines market from the bottom line, starting from its definition. Later, it segments the market on various criteria to give a depth of understanding on the various product types and pricing structures and applications. Each and every segment is examined carefully by factoring in sales, revenue and market size in order to understand the potential of growth and scope.

Various factors are responsible for the markets growth trajectory, which are studied at length in the report. In addition, the report lists down the restraints that are posing threat to the global Nanomedicines market. It also gauges the bargaining power of suppliers and buyers, threat from new entrants and product substitute, and the degree of competition prevailing in the market. The influence of the latest government guidelines is also analyzed in detail in the report. It studies the Nanomedicines markets trajectory between forecast periods.

Some of the Top Companies Profiled in this Market includes:

Global Nanomedicines Market Segmentation:

Market Segmentation: By Product

Market Segmentation: By Nanomolecule Type

Market Segmentation: By Application

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Key questions answered in the report include:

Table of Contents

Global Nanomedicines Market Research Report

Chapter 1 Nanomedicines Market Overview

Chapter 2 Global Economic Impact on Industry

Chapter 3 Global Market Competition by Manufacturers

Chapter 4 Global Production, Revenue (Value) by Region

Chapter 5 Global Supply (Production), Consumption, Export, Import by Regions

Chapter 6 Global Production, Revenue (Value), Price Trend by Type

Chapter 7 Global Market Analysis by Application

Chapter 8 Manufacturing Cost Analysis

Chapter 9 Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10 Marketing Strategy Analysis, Distributors/Traders

Chapter 11 Market Effect Factors Analysis

Chapter 12 Global Nanomedicines Market Forecast

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Nanomedicines Market will touch a new level in upcoming year with Top Key Players like Abbott, GE Healthcare, Johnson & Johnson, Merck, Pfizer,...

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How FDA Is Monitoring The COVID-19 Product Market – JD Supra

Products

Marketing Statements

CBD Products

CBD products

CBD products

CBD products

CBD products

CBD products

CBD products

CBD products

Dietary Supplements and Vitamins

Vitamin C product

Vitamin D products

Super C, Vitamin D/K2, Zinc Charge, and Immuno-Strong Berry Liquid

NoronaPak products, including supplement products

Dietary supplements

Grapefruit seed extract, colostrum, and cod liver oil products

Essential Oils

Essential oils and dietary supplements

Essential oil products

Essential oil products

Essential oil products

Essential oil products

Essential oil products

Essential oil products

Essential oils and herbal products

Herbal Products

Herbal products

Herbal products

Herbal products

Herbal tinctures and herbal remedy products

Herbal products including CoronaDefender Herbal Sachet-S

Herbal products, including Carahealth Immune

Coronavirus Protocol (Coronavirus Boneset Tea, Coronavirus Cell Protection, Coronavirus Core tincture, Coronavirus Immune System, and Elderberry Tincture)

Formula #1, Formula #2, Formula #3, and Eupatorium perfoliatum (Boneset)

Homeopathic Products

Homeopathic Genus Epidemicus

Homeopathic drugs and dietary supplement products

Homeopathic drug products

Homeopathic drugs

Sanitizer/Antimicrobial Products

Non-alcohol based hand sanitizer product

Non-alcohol based sanitizer products

Prefense Hand Sanitizers

Germ Stopper products

Sani-Bar GK95 and Sani-Disc GK95D

Products labeled to contain Silver

Colloidal silver products

Colloidal silver products

Colloidal silver products

Products labeled to contain silver

Silver Sol Liquid and products labeled to contain silver

Quicksilver Liposomal Vitamin C w/ Liposomal, Jigsaw Magnesium With SRT, and products labeled to contain silver

Superblue Silver Immune Gargle, SuperSilver Whitening Toothpaste, SuperSilver Wound Dressing Gel and Superblue Fluoride Free Toothpaste

HealthMax Nano-Silver Liquid, Silver Biotics Silver Lozenges with Vitamin C, and Silver Biotics Silver Gel Ultimate Skin & Body Care (collectively, your silver products)

Colloidal silver, vitamins, minerals, herb oils, and a homeopathic drug product

Liquid Silver, Camu Camus Vitamin C, Vitaly C, Immunity Kit, Vitamin D3-K2, and Power Immune

Silver, CBD products, iodine, medicinal mushroom, selenium, zinc, vitamin C, vitamin D3, astragalus, and elderberry

Other Products

Miracle Mineral Solution (MMS) (chlorine dioxide)

Fortify Humic Beverage Concentrate and Electrify Fulvic Beverage Concentrate

Honey product, COVID-19 COUGH Syrup

Salt therapy products

FullerLifeC60

Viral Defense Tincture

Traditional Chinese medicine products

China Oral Nosode, described as AN330 CORONA VIRAL IMMUNE SUPPORT AND/OR ACTIVE RESPIRATORY INFECTION FOR ALL AGES

Kratom products

Ayurvedic products

nCoV19 spike protein vaccine

CORE and IMMUNE SHOT

Defend Patch

NAD+ and NMN sublingual gel products

Corona-Cure Coronavirus Infection Prevention Nasal Spray

Viral Protection Kits

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How FDA Is Monitoring The COVID-19 Product Market - JD Supra

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Ohio State researchers testing breathalyzer to detect COVID-19 – The Ohio State University News

One of the most common COVID-19 tests involves a long swab pressed deep into the nasal cavities and while the test can be administered quickly, it has been described as unpleasant and uncomfortable.

Now researchers at The Ohio State University are working on a testing system that would require a simple exhaled breath. Perena Gouma is the primary investigator of a team developing a breathalyzer device that will sample breath for key biomarkers of the infection. She says it would serve as an alternative to current tests that are expensive, can take a long time to get results and require specialized personnel to do the sampling and to analyze the results.

Gouma, director of the Advanced Ceramics Research Laboratory and professor in the College of Engineering, is working with co-investigator Andrew Bowman, associate professor of veterinary preventive medicine. The project was awarded a nearly $200,000 National Science Foundation EAGER grant this month under a program supporting exploratory, early-stage research on untested, but potentially transformative, ideas or approaches.

Breath analysis is not really a technique that is used widely in the medical field yet, so it is considered early-stage work, Gouma said. [We] have a sensor device that detects nitric oxide and VOCs (volatile organic compounds) in breath and can be used to tell you about the onset of an infectious disease.

In addition to nitric oxide, the device examines two other metabolites that could specifically indicate the presence of a COVID-19 infection even in asymptomatic patients. Exhaling once in the breathalyzer may help with earlier detection of the onset of the disease, as well as with monitoring of the severity of the infection, which could help reduce the risk for worsening of the symptoms and allow timely therapeutic intervention, she said.

The new project builds upon Goumas invention of a hand-held breathmonitor that may provide early detection of flu before symptoms appearprior to her arrival at Ohio State. The COVID-19 breathalyzer involves advances on nanomaterials for detecting specific breath gases at the concentrations of interest for making a diagnosis.

The breathalyzer gives results rapidly (15 seconds response time), it is extremely inexpensive, and it is easy to use so that there is no need for trained personnel to perform the test, Gouma said. The results can be viewed directly on the display or they can be transferred to the physician wirelessly.

We are working on making these hand-held monitors that will be widely distributed and theyre very inexpensive, she said. The technology evolved from the sensors used for monitoring gases in an automotive exhaust thats how we started on breath analysis 20 years ago.

Gouma said the NSF-funded project would not have been possible without the collaboration with the College of Veterinary Medicine, the College of Medicine and the Wexner Medical Center. She said these connections make Ohio State very appealing for interdisciplinary research between engineering and medicine (nanomedicine).

Thats one of the advantages of Ohio State. You dont find many institutions that have the No. 1 vet med school in the world and also a world-class medical school, she said. Its also serendipity because COVID-19 is a zoonosis, a disease that comes from animals, and the vet med school had years of experience studying coronaviruses and the flu in animals.

Furthermore, the Wexner Medical Center has been treating COVID-19 patients from the beginning of the pandemic, so it offers unique insights to this project.

Gouma said the collaboration is critical for engineers developing medical diagnostics for humans and animals who need to consult with colleagues who have expertise in medicine to ensure that the ideas have merit and to validate their claims through clinical trials.

If the device proves to be accurate, portable and effective, it could be used to screen travelers before they step on a flight or to test students and teachers before they head back into the classroom. It would also be used in the Medical Intensive Care Units and in every hospital and doctors office as a bedside test. Gouma said the breathalyzer technology may become the platform to help detect metabolic problems like cancer, Alzheimers disease or diabetes, by choosing the appropriate biomarker

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