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Category Archives: Genetic Therapy

Occult HCV or delayed viral clearance from lymphocytes of Chronic HCV genotype 3 patients after interferon therapy

Background:A recently discovered occult HCV entity reported by various investigators seems to be highly controversial. Especially, the clinical significance of these findings remains uncertain. For optimal outcome of antiviral therapy, investigation of occult HCV needs a broad-based probe in order … Continue reading

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HCV entry receptor as potential targets for siRNA based inhibition of HCV

Background:Hepatitis C virus (HCV) is a major health concern with almost 3% of the world's population (350 million individuals) and 10% of the Pakistani population chronically infected with this viral pathogen. The current therapy of interferon-alpha and ribavirin against HCV … Continue reading

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Biodistribution and blood clearance of plasmid DNA administered in arginine peptide complexes

Background Peptide/DNA complexes have great potential as non-viral methods for gene delivery. Despite promising results for peptide-mediated gene delivery technology, an effective systemic peptide-based gene delivery system has not yet been developed.Methods This study used pCMV-Luc as a model gene … Continue reading

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Establishment of stable Huh-7 cell lines expressing various Hepatitis C Virus Genotype 3a protein: An in-vitro testing system for novel anti-HCV drugs

Background:Hepatitis C virus (HCV) infection is the leading cause of chronic hepatitis which progresses to hepatocellular carcinoma (HCC) afflicting >170 million people worldwide. HCV 3a is the most common genotype (about 70% of all genotypes) circulating in Pakistan. Expression of … Continue reading

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Comparative analysis of macrophage associated vectors for use in genetic vaccine.

Background:Antigen presentation by non professional antigen presenting cells (APC) can lead to anergy. In genetic vaccines, targeting the macrophages and APC for efficient antigen presentation might lead to balanced immune response. One such approach is to incorporate APC specific promoter … Continue reading

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Altering alpha-dystroglycan receptor affinity of LCMV pseudotyped lentivirus yields unique cell and tissue tropism

Background:The envelope glycoprotein of lymphocytic choriomeningitis virus (LCMV) can efficiently pseudotype lentiviral vectors. Some strains of LCMV exploit high affinity interactions with alpha-dystroglycan (alpha-DG) to bind to cell surfaces and subsequently fuse in low pH endosomes. LCMV strains with low … Continue reading

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