Category Archives: Biochemistry

DUBLIN--(BUSINESS WIRE)--

Research and Markets (http://www.researchandmarkets.com/research/fc33c1/essentials_of_medi) has announced the addition of Elsevier Science and Technology's new report "Essentials of Medical Biochemistry. With Clinical Cases" to their offering.

Expert biochemist R.V. Bhagavan's new work condenses his successful Medical Biochemistry texts along with numerous case studies, to act as an extensive review and reference guide for both students and experts alike. The research-driven content includes four-color illustrations throughout to develop an understanding of the events and processes that are occurring at both the molecular and macrolecular levels of physiologic regulation, clinical effects, and interactions. Using thorough introductions, end of chapter reviews, fact-filled tables, and related multiple-choice questions, Bhagavan provides the reader with the most condensed yet detailed biochemistry overview available. More than a quick survey, this comprehensive text includes USMLE sample exams from Bhagavan himself, a previous coauthor.

Clinical focus emphasizing relevant physiologic and pathophysiologic biochemical concepts Interactive multiple-choice questions to prep for USMLE exams Clinical case studies for understanding basic science, diagnosis, and treatment of human diseases Instructional overview figures, flowcharts, and tables to enhance understanding

Key Topics Covered:

1. Cells - Structures and Functions

2. Water, Acids, Bases, and Buffers

3. Amino Acids

4. Three-Dimensional Structure of Proteins

5. Energetics of Biological Systems

6. Enzymes and Enzyme Regulation

7. Clinical Enzymology and Biomarkers of Tissue Injury

8. Simple Carbohydrates

9. Heteropolysaccharides I: Glycoconjugates, Glycoproteins and Glycolipids

10. Connective Tissue: Fibrous and Non-Fibrous Proteins and Proteoglycans

11. Gastroentestinal Digestion and Absorption

12. Carbohydrate Metabolism I: Glycolysis and TCA Cycle

13. Electron Transport Chain, Oxidative Phosphorylation, and Other Oxygen-consuming Systems

14. Carbohydrate Metabolism II: Gluconeogenesis, Glycogen Synthesis and Breakdown, and Alternative Pathways

15. Protein and Amino Acid Metabolism

16. Lipids I: Fatty Acids and Eicosanoids

17. Lipids II: Phospholipids, Glycosphingolipids, and Cholesterol

18. Lipids III: Plasma Lipoproteins

19. Contractile Systems

20. Perturbations of Energy Metabolism: Obesity and Diabetes Mellitus

21. Structure and properties of DNA

22. DNA Replication, Repair, and Mutagenesis

23. RNA and Protein Synthesis

24. Regulation of Gene Expression

25. Nucleotide Metabolism

26. Hemoglobin

27. Metabolism of Iron and Heme

28. Endocrine Metabolism I: Introduction and Signal Transduction

29. Endocrine Metabolism II: Hypothalamus and Pituitary

30. Endocrine Metabolism III: Adrenal Glands

31. Endocrine Metabolism IV: Thyroid Gland

32. Endocrine Metabolism V: Reproductive System

33. Immunology

34. Biochemistry of Hemostasis

35. Mineral Metabolism

36. Vitamin Metabolism

37. Water, Electrolytes, and Acid-Base Balance

38. Case Studies

For more information visit http://www.researchandmarkets.com/research/fc33c1/essentials_of_medi

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Research and Markets: Essentials of Medical Biochemistry. With Clinical Cases

Annie Pally was awarded for her mouse model of autism in the Biomedical Research Conference for Minority Students.

Emily Chambers/The Daily Cougar

An Honors biochemistry junior Annie Pally was one of 20 UH students awarded at the 11th annual Biomedical Research Conference for Minority Students in November.

With a double minor in business administration and Honors Medicine & Society, Pally received the award for her mouse model of autism, which analyzes potential methods of preventing abnormal cognitive and intellectual development.

“I’ve always been curious to see the underlying story behind scientific discoveries, to see how exactly … we develop our current understanding of science and why we perceive certain things to be the way they are,” Pally said. “Research allows for a complete independence of thought and stresses the importance of questioning both the known and unknown.”

Her research explored the effects of blocking the central cholesterol pathway, where intermediates are believed to cause the hyper-activation of a protein responsible for regular cognitive development. This hyper-activity is linked with Fragile X Syndrome, a neurodevelopmental disorder tied to autism and the most common form of inherited intellectual disability.

“Fragile X Syndrome results from the absence of Fragile X Mental Retardation Proteins, which under normal conditions is expressed in many tissues, and is particularly abundant in the brain,” Pally said . “(A correlation was found) between a lack of FMRP and the hyper-activation of a protein essential for neuronal development and brain function in the Fragile X mouse model.”

She presented her results at the conference, which held almost 1,500 students also presenting research projects. She received the poster award for her work while learning more about various other scientific studies.

“The conference provided an opportunity to interact with fellow undergraduates across the nation,” she said. “I got to learn more about the various types of groundbreaking research and understand more about their motivation to pursue research.”

This project was funded by a scholarship from the National Fragile X Foundation and the William and Enid Rosen Research Fund. It is a continuation of Pally’s previous work in Gunter P. Eckert’s lab at the University of Frankfurt in Germany through a summer internship with the DAAD-Research Internships in Science and Engineering program.

“That experience was truly better than I could have ever imagined. It was the best of both worlds, combining my love for science with a love for travel and (my) taste for adventure,” she said. “It was a refreshing immersion into a completely different lifestyle and environment from both a cultural and scientific perspective.”

Pally received a lot of support from her family, friends and research advisors. Her mentor, assistant professor of pharmacology MariVi Tejada-Simon, saw this as an opportunity to involve Pally in hands-on laboratory research and allow her to explore her interest in the field.

“I like to give undergraduates the opportunity to either realize they like research or realize that research is just not for them,” Tejada-Simon said. “I commit myself to guiding students through the issues they are going to encounter when they dedicate their life to science in terms of research.”

The chance to experiment with this research project seemed to do just what Tejada-Simon was hoping for. It allowed Pally to find self-confirmation for her interest in the field of research and invest in a plan to continue with it.

“Often times, the most rewarding experiences are those that are most unexpected. I am very grateful to everyone who made this opportunity possible,” Pally said. “I hope to pursue a future in the medical field; in particular, the clinical correlate of pediatric neurodevelopmental disorders.”

news@thedailycougar.com

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Cougar wins research award

DeKALB (NIU) -- NIU Professor Tao Xu, who has developed a promising nanoscience research program in solar energy conversion, is now getting a big boost from the National Science Foundation.

NSF has awarded the chemistry and biochemistry professor with a prestigious Faculty Early Career Development (CAREER) grant of $400,000 over the next five years in support of his research and teaching efforts.

CAREER awards support junior faculty who exemplify the role of teacher-scholars through outstanding research, excellent education and the integration of education and research.

“This award is a tribute to the quality and productivity of Dr. Xu and his research group,” said Jon Carnahan, chair of the Department of Chemistry and Biochemistry. “We’re very proud of Tao’s accomplishment.”

Xu also is affiliated with NIU’s Institute for Nano Science, Engineering, and Technology. His research group is working to develop potential solar cells of the future.

“Because of environmental concerns related to nuclear and fossil-fuel-based energy, people are demanding clean alternative energies that can help build up our power grids,” Xu said. “Solar cells are quite safe, but we need to enhance their overall efficiency and affordability. To accomplish this, our group is trying to gain a better understanding of the fundamental processes at work in solar cells.”

The trick is to create cells that are good at both trapping light and generating electricity.

Thick solar cells have properties that are beneficial for capturing light but are inefficient for extraction of electricity and cost more for materials. Thin cells use fewer materials and efficiently generate electricity but are less effective at catching light. Through a nanotechnology process of folding material within the cell, Xu is hoping to create thin cells that are also excellent light catchers.

Xu’s group also is developing novel, environmentally friendly materials that use sunlight as an energy source to burn away organic pollutants from wastewater. The scientists have published a number of journal articles on the topic. Xu hopes the technique could be used for purification of sewage or even oil-contaminated water.

“The CAREER award is a big encouragement for my entire research group, which includes graduate students, undergraduates and research scholars who have been working so hard and intelligently on this project in the past years,” Xu said.

With the new funding, Xu hopes to expand his ongoing research collaboration with Argonne National Laboratory to include more NIU students.

“Energy science is Argonne’s core research area, and I see broadening the collaboration as an effective way to train the next generation of scientists,” Xu said. “NIU students will be exposed to Argonne’s world-class research environment and involved in frontline research projects at a young age. They will also benefit from exposure to scientific teamwork, cutting-edge facilities, cross-disciplinary knowledge and critical-thinking and problem-solving methodologies.”

Xu is the second faculty member in the chemistry and biochemistry department to win a CAREER award from NSF in recent years. Professor James Horn was awarded the grant in 2010 for his research on proteins.

Originally posted here:
Chemistry Professor Tao Xu receives CAREER Grant from National Science Foundation

23 February 2012

Associate Professor Gareth Denyer, from the School of Molecular Bioscience, has won the 2012 Invitrogen Life Technologies Education Award from the Australian Society for Biochemistry and Molecular Biology.

TheInvitrogenLife Technologies Education Award recognises outstanding achievement in education in biochemistry or molecular biology, especially innovation and creativity in education.

Associate Professor Denyerwill receive his award at theComBio conferenceto be held on 23-27 September 2012 at the Adelaide Convention Centre. As part of the award, he will give the main presentation of the Education Symposium at ComBio.

"I'm very humbled to win the Life Technologies Education Award and feel somewhat guilty to get the award because I think that there are several people in my School who are better teachers than me!" said Associate Professor Denyer.

"The buzz that I get from teaching comes from helping students who are struggling. To be the person that enables a student to finally understand a concept that has troubled them for perhaps years is an amazing thing."

Winning the award for his excellent teaching based on his philosophy of focusing on practical teaching outcomes and a minimum of teaching jargon, Associate Professor Denyer is passionate about being creative and experimenting with his teaching. He shows leadership in designing courses, administration and, most recently, the introduction of electronic lab notebooks and student portfolios.

"My teaching philosophy has been shaped by several people who have inspired me and provided guidance along the way in my career, including academics at the University of Oxford where I completed my undergraduate and postgraduate degrees, and here at the University of Sydney, where I have worked for more than 20 years," said Associate Professor Denyer.

"I've been inspired by the various ways that these academics provide a sensitive and inspiring education, so I find the modern trend of judging teachers largely by scholarship and pedagogic research unfortunate. I am passionate about judging teachers by how well they teach.

"Therefore, I am really grateful to theAustralian Society for Biochemistry and Molecular Biologyfor choosing me for the Education Award and I hope it will encourage others who want to enjoy and be effective in their teaching to do so through creativity, experimentation and reflection."

In his presentation at the Education Symposium at ComBio, Associate Professor Denyer will present on his most recent teaching innovations, including the ePortolio/eNotebook, the classes that he and colleagues have set up to build students' confidence in criticising the research literature, the anti-plagiarism solutions that they use in exams and the narrated meta-lectures which provide commentaries on lectures similar to the producer commentaries that come with a movie DVD.

As part of the Invitrogen Life Technologies Education Award, he will also be sent to an international conference of his choice with a significant focus on education.

"I am hoping to attend the conference associated with the ePortfolio system that we are using as a surrogate electronic Lab Notebook. I hope to be able to convince the authors of that software to make changes that will enable the ePortolio system to work as a modern eNotebook which can be used in many other disciplines and even in the real research lab environment."

Read moreabout the Invitrogen Life Technologies Education Award and other Australian Society for Biochemistry and Molecular Biology awards on the Australian Society for Biochemistry and Molecular Biology website.

Media enquiries: Katynna Gill, 02 9351 6997, katynna.gill@sydney.edu.au

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Gareth Denyer wins Life Technologies Education Award

DUBLIN--(BUSINESS WIRE)--

Research and Markets (http://www.researchandmarkets.com/research/ad0c22/pathophysiology_p) has announced the addition of Elsevier Science and Technology's new report "Pathophysiology, pharmacology and biochemistry of dyskinesia" to their offering.

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding the movement disorder Dyskinesia. Key Features

Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Topics Covered:

An introduction to dyskinesia: the clinical spectrum L-dopa induced dyskinesia - clinical presentation, genetics and treatment Experimental models of LID Mechanisms underlying LID Novel approaches to therapy Surgical approaches to LID Tardive dyskinesia - clinical presentation and treatment Epidemiology and risk factors for TD Genetics of TD Heon Experimental models of TD Surgical approaches to TD Huntington's chorea - clinical presentation and treatment Genetics and pathology of HD Pathogenic mechanisms in HD Experimental models of HD and novel therapeutic approaches Cell based treatments for HD Clinical phenomenology of dystonia Genetics and pharmacological treatment of dystonia Experimental models of dystonia Surgical treatment of dystonia

For more information visit http://www.researchandmarkets.com/research/ad0c22/pathophysiology_p

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Research and Markets: Pathophysiology, Pharmacology and Biochemistry of Dyskinesia

03-08-2011 13:32 Lecture by Kevin Ahern of Oregon State University discussing Biochemistry Basics in BB 451. See the full course at oregonstate.edu This course can be taken for credit (wherever you live) via OSU's ecampus. For details, see ecampus.oregonstate.edu Download Metabolic Melodies at http://www.davincipress.com Related courses include BB 350 - oregonstate.edu BB 450 - oregonstate.edu BB 100 - oregonstate.edu Nucleotide Metabolism 1. Nucleotides consist of a) sugar, b) nitrogenous base, and c) phosphate 2. Nucleosides consist of aa) sugar and b) nitrogenous base 3. The sugars of nucleosides and nucleotides are either ribose (found in ribonucleotides of RNA) or deoxyribose (found in deoxyribonucleotides of DNA). 4. The nitrogenous bases found in nucleotides include adenine (purine), guanine (purine), thymine (pyrimidine), cytosine (pyrimidine), and uracil (pyrimidine). 5. The bases adenine, guanine, and cytosine are found in both ribonucleotides and deoxyribonucleotides. Thymine is almost always found in deoxyribonucleotides. Uracil is found primarily in ribonucleotides and rarely in DNA, but does appear as a deoxyribonucleotide intermediate in thymidine metabolism. 6. Ribonucleotides are the building blocks of RNA and deoxyribonucleotides are the building blocks of DNA. 7. Nucleotides and nucleosides are made in cells by two general mechanisms - salvage pathways (use breakdown products of other nucleotides/nucleosides) or de novo pathways (synthesize nucleotides/nucleosides from scratch ...

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Bite-Sized Biochemistry #39 - Nucleotide Metabolism I - Video