Category Archives: Anti-Aging Medicine

A University of Alabama cancer geneticist is taking his anti-aging research to the next level to effectively end age-related hair loss, wrinkled skin and reduced energy. And he hopes to have products on the market in 5 years.

A new startup out of the University of Alabama at Birmingham (UAB), Yuva Biosciences, is essentially the result of Keshav Singhs attempt to help chemotherapy patients re-grow the hair they lose as a result of the cancer treatment. But what he found could help everyone.

Cropped composite image of a woman when she was young and old

Yuvawhich means youth in Hindihopes to tap into the multi-billion-dollar hair loss prevention and anti-aging skincare market with cosmeceuticals, science-based cosmetics and pharmaceuticals based on its founders research into mitochondrial DNAthe tiny part of cells that produce 90 percent of the chemical energy they need to survive.

Singh said along with causing skin to age and hair to fall out, mitochondrial dysfunction can drive age-related diseases. A depletion of the DNA in mitochondria is also implicated in human mitochondrial diseases, cardiovascular disease, diabetes, age-associated neurological disorders and cancer.

Last year, Singh and his colleagues at UAB reversed wrinkles and restored hair growth in mice. The team triggered a gene mutation that caused mitochondrial dysfunction in mice, causing them to develop wrinkled skin and lose their hair. The UAB researchers discovered that turning off that mutation restored the mice to normal appearance making them indistinguishable from healthy mice of the same age. In effect, when the mitochondrial function was restored, the mice regained smooth skin and thick fur.

The mouse in the center photo shows aging-associated skin wrinkles and hair loss after two months of ... [+] mitochondrial DNA depletion. That same mouse, right, shows reversal of wrinkles and hair loss one month later, after mitochondrial DNA replication was resumed. The mouse on the left is a normal control, for comparison.

Singh along with Bhupendra Singh, Trenton R. Schoeb and Prachi Bajpai, UAB Department of Genetics; and Andrzej Slominski, UAB Department of Dermatology shared their results in apaperin July 2018, Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function, in the journal Cell Death and Disease. The work was supported by U.S. Department of Veterans Affairs (VA) and National Institutes of Health (NIH) grants.

Now in addition to his duties as a senior scientist in the Cancer Cell Biology Program and director of the Cancer Genetics Program at the ONeal Comprehensive Cancer Center at UAB, Singh will serve as chief scientific advisor for Yuva Biosciences.

Keshav Singh, Ph.D., cancer geneticist and chief scientific advisor for Yuva Biosciences

The founding editor-in-chief of Elseviers Mitochondrion journal, Singh said scientists already knew that humans age as mitochondrial DNA content and mitochondrial function decline. He said the trick is to find a way to restore that content and function. And theyve already done that in mice. Now they want to transfer those studies and hopefully similar results to human trials.

Our plan is to look for two things, Singh said. We want to identify natural products which can enhance mitochondrial function. We have already identified at least one of these natural products that enhances mitochondrial function and also seems to prevent hair loss and wrinkles. Secondly, we want to re-purpose drugs that are already FDA-approved.

Singh said the National Institutes of Health (NIH) and the Food and Drug Administration (FDA) already has a library of thousands of FDA-approved compoundsdrugs for everything from diabetes to Alzheimers disease. We want to test them to see which ones might enhance mitochondrial function and even enhance energy, he said, adding that researchers work last year at UAB allowed us to develop a system where we can use different compounds that could enhance mitochondrial function.

Singh said the first of Yuvas products will likely be a topical therapy to halt wrinkles and hair loss and perhaps restore damage already done.

Yuva Biosciences plans to prevent or undo many of the effects of aging, which is why we like to say our goal is to provide Youthfulness for LifeTM, Singh said. Currently, we are aiming to develop productsto help people look and feel younger. Ourlong-term plan is to increase health span by addressing diseases associated with aging.

With the help of Greg Schmergel, a Boston-based serial entrepreneur, who will serve as chairman of Yuva Biosciences, Singh will occupy lab space at Innovation Depot, Inc. The Depot is a 140,000-square-foot office, lab and co-working startup space for technology companies located near UAB in Birmingham, Alabama. Yuva plans to hire two additional employees early next year.

Schmergel brings more than 25 years of experience in launching multiple high-tech ventures and leading a Massachusetts-based nanotechnology company, Nantero Inc., where he is the co-founder and CEO. A former senior vice president of corporate strategy for About, Inc., Schmergel also serves on the Board of Trustees of Lahey Hospital & Medical Centera, a physician-led nonprofit teaching hospital of Tufts University School of Medicine (TUSM) based in Burlington, Massachusetts.

In a statement, Schmergel said Yuva is committed to building the company in Birmingham, where well have access to resources like the world-class researchers and facilities at UAB, the startup-focused amenities at Innovation Depot, and the rising regional entrepreneurial network.

Scientists Robert K. Naviaux, MD. Ph.D. and Matt R. Kaeberlein, Ph.D. will serve on the Yuva Biosciences Advisory Board. Kaeberlein specializes in aging and is past president of the American Aging Association, and professor in the Department of Pathology at the University of Washington (UW), in Seattle. Naviaux specializes in mitochondrial and metabolic medicine and is a professor of Genetics at the University of California San Diego (UCSD).

Singh said there is no telling how far Yuva could go in aging research, though there is much testing yet to be done. We have discovered that mitochondria, which are the powerhouse of the cell, are the reversible regulator of wrinkles and hair loss, Singh said. The potential is huge as everyone develops wrinkles and most of us lose hair. So, any agent or drug which can slow down or reverse that will have a major impact.

Singh wouldnt speculate on whether manipulating mitochondrial DNA could cause all human organs and systems to regenerate and whether it would reverse aging in themfor example the human brain and any implications his research could have on dementia. And although little change was seen in other organs when the mutation was induced, he did hint that there is indeed great potential for further disease research.

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Geneticists Attempt To Help Chemotherapy Patients Could End Age-Related Hair Loss, Wrinkled Skin And Reduced Energy - Forbes

The global health and wellness market is often cited as the next trillion dollar industry and rightly so, considering the wealth of applications and products it incorporates in a variety of industries such as nutraceuticals and cosmeceuticals. Since a last few years, sectors such as healthy eating, nutrition, and weight loss, complementary and alternative medicine, preventative and personalized health, and beauty and anti-aging have grown in leaps and bounds. Currently, there are three trends making their presence known in the global market, viz. athleisure, boutique fitness, and organic diet. From real estate to shopping to smart technology, health and wellness has found a significant place in the everyday life of the world population.

The report on the international health and wellness market sheds light on the important segmentations by nutraceutical and cosmeceutical product types. Besides this, the analysts have explored some of the key geographical segments that the global market is anticipated to mark its territory in. With a conclusive segmentation study provided in this comprehensive publication, interested parties can take hold of the crux of the market.

Buyers of the health and wellness market publication are offered with an up-to-date analysis of the vital technological improvements and market trends. Moreover, it crafts an impact analysis along with a well-defined technological growth map. The report is a crucial guideline to understand the critical market forces restraining and propelling the global market.

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Global Health and Wellness Market: Trends

By nutraceutical product, the global health and wellness market is segmented into functional foods, functional beverages, and dietary supplements. According to cosmeceuticals, the market is segregated into cosmeceutical ingredients, cosmeceutical products, and cosmeceutical sales. The market is primarily driven by increased health awareness and boosted store presence of health and wellness products. The demand for healthcare devices, exercise equipment, organic foods, and supplementary diets has also augmented the growth of the market.

Global Health and Wellness Market: Geographical Analysis

The international health and wellness market has grown at a substantial rate not only in developed regions such as North America and Europe but also developing countries of the world. Consumer health awareness and consumer interest continue to rise in Canada on the back of the role of foods and beverages in health maintenance and their benefits. Consumers in the U.S. are anticipated to take a paradigm shift toward healthy and organic food choices as their skepticism about manmade healthy products continues.

Emerging economies such as China have persisted to show signs of growth, riding on widening consumer focus on health and increasing household income. New product development has supported the organic baby food segment. In India, the market has been propelled by the demand for health and wellness foods, increased uptake of weight control pills, and growing gym memberships.

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Global Health and Wellness Market: Competitive Overview

The report has studied some of the leading players which are vying to attain a top spot in the global health and wellness market, viz. Philips Healthcare, Abbott Laboratories, LifeScan, Inc., B. Braun Melsungen AG, Animas Corporation, LOral, Johnson & Johnson, Nestle S.A., General Mills, Inc., Coca-Cola, Omron Healthcare, F. Hoffmann-La Roche, and Medtronic, Inc. With a scrupulous analysis of the competition dynamics, it helps to gain a competitive edge in the worldwide market.

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Health and Wellness Market Analysis and Forecast up to 2024 - The Denton Chronicle

A few of the commonest signs skilled by most cancers sufferers are reminiscence issues, difficulties with multitasking, and diminished consideration and focus. Traditionally, most cancers sufferers with these signs have been usually recognized with despair. Analysis over the previous decade has revealed that many most cancers sufferers expertise such signs as a consequence of particular harm to the mind brought on by both their tumor or their therapy.

Whereas radiation to the mind has lengthy been linked to inflicting cognitive difficulties, the consequences of chemotherapy on mind construction and performance have solely lately been found. We now know that almost all of sufferers handled for most cancers, together with breast, lung, colon, and lots of different most cancers varieties, expertise difficulties with reminiscence, multitasking, cognitive processing pace, consideration, and focus as a consequence of their therapy. The excellent news is that such signs could slowly enhance over time in most sufferers.

When you or somebody you take care of is having issues with reminiscence or considering following most cancers therapy, you will need to endure a complete medical analysis to rule out different situations that may mimic sure unintended effects from chemotherapy. For instance, endocrine problems (resembling thyroid abnormalities), vitamin deficiencies, sleep deprivation, or despair ought to all be dominated out (or handled), as these situations may cause modifications in reminiscence and slowed considering.

Intensive analysis over the previous decade has recognized how chemotherapy targets mind construction and performance as an undesirable facet impact of most cancers remedy. These efforts have additionally began to make clear the mechanisms that improve mind regeneration and expedite restoration from mind damage, beforehand considered inconceivable. Whereas varied therapeutic interventions presently stay in medical testing, there are a variety of life-style actions which have been discovered to be efficient.

Drugs resembling neurostimulants and anti-aging medicine could also be used along side life-style interventions to enhance reminiscence and cognition after most cancers remedies. Converse together with your physician about these choices.

New analysis suggests there could also be a connection between the immune system, the bone marrow, and the mind, highlighting new avenues for future pharmacological and organic therapies that will improve mind operate after damage and delay the method of mind getting old.

A radical neurological analysis may be useful in figuring out areas of mind functioning that may be improved with specialised neurocognitive rehabilitation packages. Many sufferers profit from any such rehab as a part of their most cancers therapy.

Collectively, whereas signs of mind dysfunction are widespread in most cancers sufferers, there are a number of interventions that may be thought of to assist with restoration and improve therapeutic. Analysis on this space stays in its infancy, however the curtain has been lifted. There are promising pharmacological and nonpharmacological therapeutic interventions on the horizon, and there are numerous life-style modifications you can begin at present.

Neural correlates of chemotherapy-related cognitive impairment. Cortex, Might 2014.

Evaluation and administration of cognitive modifications in sufferers with most cancers. Most cancers, June 15, 2019.

Pharmacologic administration of cognitive impairment induced by most cancers remedy. Lancet Oncology, February 2019.

Sleep drives metabolite clearance from the grownup mind. Science, October 18, 2013.

Bone marrow drives central nervous system regeneration after radiation damage. The Journal of Scientific Investigation, June 1, 2018.

The put up Affected by chemo mind? Theres hope and lots of issues you are able to do appeared first on Harvard Well being Weblog.

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Affected by "chemo mind"? There's hope and lots of issues you are able to do - Exchange 99

BEVERLY HILLS, California, Nov. 21, 2019 /PRNewswire/ -- Full Alliance Group, Inc. (OTCPK: FAGI) is pleased to announce the opening of two new EBO2 treatment offices.

Dr. Yu and his staff arrived in Boca Raton, Florida, and then the Cayman Islands earlier this week with two brand-new portable EBO2 units and are currently training Dr. Joseph Purita and his staff. Dr. Purita is well-known in the stem cell and regenerative medicine sector and is eager to implement our ozone technology within his thriving practice.He has offices in Boca Raton as well as in the Cayman Islands.

Dr. Purita's Pensum Regenerative Clinic in Grand Cayman already specializes in stem cell treatment and anti-aging.The addition of EBO2 technology is expected to work synergistically with the well-established stem cell protocols already in place at the clinic.

"Expanding our footprint to the East and South, as well as the Caribbean, has been a critical part of our strategic plan," said Dr. Brian Volpp, MD, CEO and President of Full Alliance Group, Inc. "We are grateful that Dr. Purita has committed to the Yu Method and that he has made the financial commitment for two of our new units.His reputation within the stem cell community should allow ozone therapy to become more mainstream as he gains more experience with integrating EBO2 into his existing protocols."

Also, we have been advised by our legal team that the third quarter financial filing must be made publicly available to all shareholders. Consequently, the filing has been posted on our website:https://FullAlliance.com

About Full Alliance Group Inc.

Full Alliance Group Inc. (OTCPK: FAGI) is a multi-faceted holding company with various interests in technology, healthcare, and nutraceuticals. Nutra Yu, Inc., a wholly owned subsidiary of Full Alliance Group, develops, markets, and distributes a proprietary line of nutraceutical products. EBO2, Inc., a wholly owned subsidiary of Full Alliance Group, is the provider of ''EBO2'', a modern high volume blood gas exchange unit for the treatment of 5-7 liters of blood with medical ozone. The unit allows extracorporeal blood and oxygenation, ozone exposure and blood filtration.The process filters blood in a unique way by using the integrated diffusing membranes within the filter fibers to trap lipids and proteins which are in excess in the venous blood supply. The EBO2 unit is considered the world's most advanced medical ozone therapy.

For additional information regarding Full Alliance Group, visit, http://www.fullalliance.com.

Paul Brian Volpp, MD, MPH, President / CEO The Full Alliance Group

Forward-Looking StatementsThis shareholder update may contain a number of forward-looking statements. Words and variations of words such as: "expect", "goals", "could", "plans", "believe", "continue", "may", "will", and similar expressions are intended to identify our forward-looking statements, including but not limited to: our expectation for growth, benefits from brand-building, cost savings and margins. These forward-looking statements are subject to a number of risks and uncertainties, many of which are beyond our control, which could cause our actual results to differ materially from those indicated in our forward-looking statements. Such factors include, but are not limited to: continued volatility of, and sharp increase in: costs/pricing actions, increased competition, ability to raise sufficient operating capital, risks from operating internationally, consumer weakness, weakness in economic conditions and tax law changes.

Full Alliance Group Inc. Investor RelationsDave DonlinEmail: Info@TheCervelleGroup.comPhone: (407) 490-6635Web: http://www.StockInvestorDaily.comVisit: http://www.fullalliance.comContact: ir@fullalliance.com

SOURCE Full Alliance Group, Inc.

https://fullalliance.com/

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Full Alliance Group Announces New EBO2 Sites in Florida and the Caribbean - PRNewswire

This article first appeared in the Winter 2019 issue of NewBeauty. Clickhereto subscribe.

Money cant buy happiness,but it can make younger-looking skin a whole lot easier to achieve. J.Lo and Jennifer Aniston are both rumoredto have their own Ultherapymachines, and Kimora LeeSimmons has claimed touse La Mer eye cream fromhead to toe to keep things taut.What would a typical skin-care regimen look like if yourlast name was Bezos, Gatesor Arnault? These beautyexperts give us a peek at whatthe ultimate future-proofingplaybooks look like.

You May Also Like: This Is What It's Really Like to Plan a Secret Celebrity Plastic Surgery Appointment

TOX TALKSweat seems to be enemy number-one when money is noobject. Franklin, TN dermatologist Jill C. Fichtel, MD saystargeting all sweaty areas every six months is at the top ofthe to-do list, and Nanuet, NY dermatologist Heidi Waldorf, MD has her sights set on Blowtox. I already tox the backof my neck every five monthsthe bottom of my hair curlsand frizzes as sweat travels therebut, ideally, I wouldtreat my entire scalp every three months ($1,500).

BODY ROCKIf thousands of dollars in serums and lotions lined yourmedicine cabinet, why stop at your neck? A full-bodycocktail of wrinkle-plumping SkinMedica TNS Essential Serum($281), Retin-A and La Prairie Skin Caviar Luxe Cream($505)would replace any old body lotion for Boston facial plasticsurgeon Caroline A. Banks, MD. New York facial plasticsurgeon Jennifer M. Levine, MD offers up a casual solutionto slack, less-than-camera-ready skin: off-label use of hyperdiluted Sculptra Aesthetic from head to toe.

To eliminate dry, dull skin for the foreseeable future,New York cosmetic dentist Pia Lieb, DDS would drenchherself in Clarins Body Balm($43) each morning and evening;New York dermatologist Rita Linkner, MD would swap herusual hydrator with collagen-boosting Alastin Regenerating Nectar($195), and, before coating every inch of skin withBiologique Recherche Srum Placenta and Creme Masque Vernix, New York City facialist Autumn Henry would endevery long week in the most chic, drool-worthy way: relaxing in a CBD-infused milk bath in an amethyst tub.

NEEDLE WORKGravity doesnt care if youre rich, famous or an MD. Tobeat it, Miami dermatologist Stacy Marie Chimento, MDdaydreams of having Profound RF radio-frequency microneedling treatments done on her face, neck, stomachand thighs every two yearspaired with the dimple-blasting powers of VelaShape, of coursefor lifting, tighteningand cellulite-busting.

Dr. Linkner thinks like us: Id get out my Pro-Nox andUltherapy my entire body. New York dermatologist Sapna Palep, MD agrees, though shed alternate between Ultherapy and Titan. To cut down on trips to and from the office,Dr. Fichtel would buy her own Emsculpt device to leave athome. The ultimate home gym equals Emsculpt, couch,boxed wine and Netflix.

Dr. Levine chimes in with her dream fat-busting regimen: noninvasive SculpSure to those stubborn areas resistant tohours at the gym. "I'd start with abdomen and flanks, then arms, then finally the inner and outer thighs."

FAT FREEZEDr. Waldorf is currently living our fat-freezing dreams. Seea bulge, freeze a bulge has kept me fit and fitting into mywardrobe, she says. When I lecture on CoolSculpting, Ioften do my CoolSculpting macarenamy hand movements mirror all the places and times Ive had it done: lowerbelly, upper belly, waist, flanks, bottom of my butt, upperarmsand repeat! I think Im up to 18 cycles since 2012.

LIGHTEN UPTo undo the photodamage he incurred as a kid, New Yorkdermatologist Joshua Zeichner, MD says he would Fraxelthe entirety of his sun-exposed skin. Forget costif socialdowntime wasnt a factor, I would microneedle my facewith PRP every month, says Greenwich, CT dermatologistKim Nichols, MD. And for the most relaxing dose of brightening power, Englewood, NJ plastic surgeon Shwetambara Parakh, MD would top her monthly whole-body HydraFacial sessions with bottles of SkinCeuticals C E Ferulic($166).

LUST LIST

1. An LED light-therapybed would be upthere on my wishlist, says cosmeticformulator StephenAlain Ko. Whilethe research isntparticularly convincing, the thought oflaying in a warm,quiet, meditativespacewith propereye protection, ofcoursewhile doingmy skin care reallyappeals to me.

2. Skin-care superstarCaroline Hironsfull-body cocktailincludes La Mer Body Cream($195) andher secret weapon:Kate Somerville Deep Tissue Repair Cream($150) twice a day,head to boobs.

3. I would buy a timemachine and startusing productsearlier to preservemy youthand getmy NeoGraft hairtransplant 15 yearsearlier, says GrandRapids, MI plasticsurgeon Bradley Bengtson, MD.

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An Inside Look at the Anti-Aging Regimens of the Rich and Famous - NewBeauty Magazine

BEIJING--(BUSINESS WIRE)--Pengmen International based in the Chinese capital, is combining health and beauty, using ancient Chinese medicine and modern technology to turn rare and expensive red sandalwood into natural beauty products. The company is trying to simplify the product, which can be used in everyday life to make people feel younger. Even more surprising, the company is trying to get more people to use the product at a affordable price.

Health preservation medicine was invented by the Chinese thousands of years ago. In China's imperial palaces, emperors used a rare spice called sandalwood to the extreme, even making tables and chairs for their use. This rare ingredient is used in the top products of France's world-famous brands Chanel and Hermes.

Now, Pengmen International has turned the extremely rare red sandalwood used only by emperors into cosmetics. "Qian Li Mu" brand cleverly uses the integration of eastern Chinese medicine and western modern lifestyle to create "cosmetics" that can not only make people beautiful. Red sandalwood cream, which is said to have been copied from an ancient Chinese palace recipe more than 1,000 years ago (in the Tang Dynasty), can make people younger with daily cleaning. They also made red sandalwood into lipsticks and skin care products, which can remove spots and smooth wrinkles. Even Nobel winner Dr. Murad's Nitric oxide technology was used to combine with wild rosewood to produce a "skin lotion" . "From royalty to family, from emperors to us" is the company's vision, which ultimately serves the global public.

In addition, the company also combined French red wine and red sandalwood, brewing the unique red sandalwood dry red, known as the tree of life. This dry red is beneficial to the protection of cardiovascular and cerebrovascular cells and clean, can fight aging and prevent tumors.

It has been found that pterostilbene is the best natural plant antioxidant found so far and is being used in anti-tumor and anti-aging research in western countries. But natural red sandalwood has a limited stock and is internationally regulated, so these cosmetics made of red sandalwood may end up being available to a very small number of people.

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Pengmen International Uses Traditional Chinese Medicine and Modern Technology to Make Red Sandalwood Natural Beauty Products - Business Wire