Category Archives: Anti-Aging Medicine

12 Jun 2020

Rare variants in TREM2 and PCLG2 influence a persons odds of developing Alzheimers disease, but that is far from all the two genes have in common. According to a study published June 8 in Nature Neuroscience, phospholipase C 2 acts downstream of TREM2 in a signaling pathway that supports critical microglial functions. Using human microglia derived from induced pluripotent stem cells, researchers led by Joseph Lewcock at Denali Therapeutics in South San Francisco reported that knocking out either gene product prevented the immune cells from efficiently processing lipids and neuronal debris. The researchers also found that, independently of TREM2, PLC2 is involved in a pro-inflammatory side hustle dictated by toll-like receptors, which, it so happens, is exacerbated by intracellular lipid build-up. Taken together, the findings strongly implicate faulty microglial lipid handling in the etiology of AD, and support therapeutic strategies that aim to rev up TREM2 signaling.

Using an impressive array of experimental conditions in gene-edited iPSC-microglia, [the authors] demonstrate that PLC2 is a downstream effector of TREM2 and a regulator of lipid metabolism. This exciting discovery directly connects PLC2 to well-established AD pathways involving APOE, TREM2, and microglial activation, commented Rik van der Kant, Vrije University, Amsterdam (full comment below). Florent Ginhoux of the Agency for Science, Technology and Research in Singapore, agreed. The study elegantly links TREM2 and PLC2 signaling pathways, and offers mechanistic insight into how variants in these genes affect the pathophysiology of AD, Ginhoux wrote (full comment below).

Double Dealing. When triggered by TREM2, PLC2 supports lipid metabolism and survival (left). When triggered by TLRs, PLC2 triggers inflammation. In TREM2 KO microglia (right), lipids accumulate and this exacerbates the pro-inflammatory, TLR-driven pathway. [Courtesy of Andreone et al., Nature Neuroscience, 2020.]

Since the discovery, in 2012, that rare variants in the coding region of TREM2 triple the risk of AD, researchers have pegged the receptor as supporting myriad microglial functions, including phagocytosis, walling off A plaques, and promoting an anti-inflammatory, neuroprotective environment (May 2016 news; Apr 2017 conference news;Jul 2018 conference news).

Separately, researchers discovered a rare variant in phospholipase C 2 (PLCG2) that protects against AD (Aug 2017 conference news on Sims et al., 2017). PLCs are a large family of intracellular enzymes that cleave the membrane phospholipid phosphatidylinositol-4,5-bisphosphate (PIP2) to diacylglycerol (DAG) and inositol-1,4,5-trisphosphate (IP3), a process that facilitates calcium signaling. In the brain, the 2 isoform is predominantly expressed by microglia, and initial studies suggest that the protective variant munches phospholipids with more gusto than the common one does (Zhang et al., 2014; May 2019 news).

Might the functions of TREM2 and PLC2 intersect in microglia? To study this question, co-first authors Benjamin Andreone and Laralynne Przybyla derived human microglia. They wove together elements from three recently developed protocols to coax so-called induced microglia (iMGs) from induced pluripotent stem cells (Muffat et al., 2016; Pandya et al., 2017; McQuade et al., 2018). They then used CRISPR to wipe out expression of TREM2 or PLCG2 in these cell-based models.

Under normal conditions, iMGs missing either TREM2 or PLCG2 appeared healthy and viable. When the going got toughi.e., when growth factors were depleted from the culture mediaboth types of knockout suffered a similar fate, dying sooner than their wild-type counterparts. The transcriptomes of each of the two iMG knockouts also differed from those of wild-type cells in similar ways. Specifically, half of the genes differentially expressed in TREM2 KO iMGs were similarly affected in PLCG KO iMGs. These common genes were part of signal transduction pathways downstream of DAP12, the adaptor protein that mediates TREM2 signaling. Using biochemical approaches, the researchers ultimately pieced together a signaling cascade by which lipids activate TREM2, leading to the phosphorylation of Syk2, which directly interacts with PLC2, unleashing its phospholipase activity and downstream signaling events.

Disabling the pathway, either by knocking out TREM2 or PLC2, had a dramatic impact on the processing of lipids, including cholesterol-laden myelin. All microglial lines in this study readily engulfed this type of fluorescently labeled debris; however, while wild-type cells had largely disposed of it after four days, TREM2 or PLCG2 knockouts were still chock-full of it by then. Tellingly, perhaps, the knockout cells failed to ramp up expression of several lipid processing genes in response to the myelin challenge.

Choking on Lipids? Wild-type microglia (left) readily digested lipids after treatment with myelin, while microglia lacking PLCG2 (middle) and TREM2 (right) accumulated the lipids. [Courtesy of Andreone et al., Nature Neuroscience, 2020.]

Lipidomics experiments revealed that the knockouts became burdened with a backlog of several subtypes of unprocessed lipid, including free cholesterol, cholesteryl esters, and myelin-derived ceramides. Similarly, in co-culture experiments with iPSC-derived neurons, both types of microglial knockout were unable to properly digest detritus from injured axons.

How might AD risk variants shift these phenotypes? The researchers generated iMGs that expressed the R47H variant of TREM2, or the protective P522R variant of PLCG2. As might be expected from prior findings on these variants, the R47H-TREM2 iMGs processed lipids more sluggishly than wild-type, whereas the P522R-PLCG2 microglia more deftly disposed of them than wild-type. Together, the findings support the idea that TREM2 and PLCG2 variants influence AD risk via lipid metabolism.

Lest a reader be tempted to tie a neat little bow on this set of results, here comes the twist: PLC2 also takes marching orders from toll-like receptors. This was previously reported in peripheral immune cells. The Denali researchers found the same in iMGs, as PLCG2 knockouts failed to mount a pro-inflammatory response to the TLR2 ligand zymosan.

Interestingly, the same pro-inflammatory cytokines that were down in response to zymosan in PLCG2 knockout iMGs were up in TREM2 knockout iMGs. For example, compared with wild-type iMGs treated with zymosan, PLCG2 knockouts secreted 50 percent less IL-1, while TREM2 knockouts secreted 64 percent more.

The same pattern emerged when the researchers used the TLR4 ligand LPS to trigger the microglial NLRP3 inflammasome, which itself has been tied to AD (Nov 2019 news). Loading up the microglia with myelin prior to triggering the inflammasome dramatically enhanced the inflammatory response in TREM2 KO iMGs, the scientists report. This implies that intracellular lipid accumulation may exacerbate damaging inflammatory pathways. The findings dovetail with those of a recent study that tied lipid droplet-accumulating microglia (LAM) in the aging hippocampus to neuroinflammation (Aug 2019 news).

Overall, the findings cast PLC2 as a two-faced player in microglia. When triggered via TREM2, this phospholipase facilitates processing of lipids and microglial survival. When tripped off by TLRs, it ramps up potentially damaging pro-inflammatory responses. And when lipids build up, as might occur in the aging brain, they exacerbate the pro-inflammatory pathway, Andreone told Alzforum. He believes the balance between these two PLC2 signaling pathways could dictate whether microglia help or harm.

The findings lend support to a therapeutic strategy of agonizing TREM2 signaling, Lewcock told Alzforum. That the protective PLC2 variant enhances lipid processing in microglia fits with the idea that even people whose TREM2 functions normally could stand to benefit from a boost in this pathway. Activating PLC2 is also a potential strategy, Lewcock said, although it would come with the risk of rousing its pro-inflammatory side. More work is needed to dissect how the PLC2 protective variant influences signaling downstream of TREM2 versus TLRs.

This is a very important paper, wrote Christian Haass at the German Center for Neurodegenerative Diseases in Munich. Haass noted that its findings fit with fresh data from his and other groups, but also cautioned that the molecular signature of a protective subpopulation of microglia needs to be defined in much greater detail (full comment below).

Denali is collaborating with Haass group to develop an activating antibody for TREM2, which will come with a blood-brain barrier transport vehicle to shuttle it into the brain (May 2019 conference news;May 2020 news).AL002, a TREM2-activating antibody developed by Alector and Abbvie, entered early clinical trials last year (see clinicaltrials.gov).Jessica Shugart

No Available Further Reading

Read the original post:
Janus-Faced PCL2? Alzheimer's Risk Protein Toggles TREM2 and TLR Pathways - Alzforum

(MENAFN - Straits Research) In Ayurveda, the key to effective medicine is the selection of a combination of pure, potent herbs. When designing a formula, the focus is mainly given on the root of the problem and ways to alleviate the pain, making the product as safe as possible and making sure that the problem doesn't resurface. Grocare's primary focus is to go to the root of a problem and make sure that it doesn't recur, by developing such effective herbal products.

Oronerv made with the goodness of several powerful bio herbs like Commiphora Mukul, Pluchea Lanceolata, Withania Somnifera, and Paederia Foetida, Oronerv is a product that was developed to help restore and harmonize the nervous and vascular system in the body. This Oronerv product helps in eliminating toxins and impurities by increasing the blood flow throughout the body. These toxins and impurities are the major cause of inflammation within the veins. The herbs that are used to make this product are pure and herbal, and hence predominantly anti-inflammatory by nature. Thereby, it helps to reduce the pressure in the veins and stabilize the blood flow throughout the body.

These are the essential herbs that are included while formulating the product:

1. Commiphora Mukul: This herb is known for its anti-inflammatory and pain-relieving (analgesic) properties. Hence, it is the best choice for usage in arthritic pains, as it helps in overturning the degenerative changes that occur in joints and bones. Furthermore, it also helps stabilize the thyroid gland, which looks after the metabolism and also controls imbalances in the thyroid. The herb also helps in the purification of blood, thereby increasing blood circulation in the body.

2. Pluchea Lanceolata: Known for its anti-inflammatory properties, Pluchea Lanceolata helps in reducing muscle and joint pains. Besides, it works as an antioxidant and also hunts for free radicals in cells responsible for premature aging. The herb also acts as a Nervine Tonic.

3. Withania Somnifera: This bio herb acts as a Nervine Tonic and possesses anti-inflammatory effects. Withania Somnifera is primarily used in boosting the immune system and promoting the overall health of an individual. Moreover, it acts as a powerful antioxidant that looks for free radicals in the body.

4. Paederia Foetida: This herb is known for containing essential oils responsible for its anti-inflammatory and antispasmodic effects that can quickly alleviate bone and joint pains. Paederia Foetida also works well for rheumatism. It acts as a blood purifier and increases blood circulation in the body.

Proper Usage of This Medicine:

This product works best if taken twice daily after meals, or as recommended by the healthcare professional or as indicated by inappropriate disease medication. Oronerv is used in the treatment of several health conditions, including rheumatoid arthritis, vertigo, varicocele, tinnitus, Parkinson's disease, and varicose veins.

Side-effects Associated With This Medicine:

If taken within the prescribed dosage, Oronerv doesn't result in any known side-effects. The product can be consumed safely by individuals with diabetes, hypertension, high blood pressure, and pregnant women. Oronerv is not known to cause any harm or adverse effect in any of the mentioned cases.

About Grocare:

Grocare is a herbal pharma company offering natural solutions for chronic lifestyle disorders. we provide herbal supplementsforchronic lifestyle diseases such as hernia, varicocele, kidney stone, h pylori, piles, tinnitus, UTI, Prostate Enlargement, etc.through e-commerce worldwide.

MENAFN12062020007010339ID1100317336

More:
India- Ayurvedic Medication For A Healthy Nervous And Vascular System | Grocare - MENAFN.COM

Protests over the police killing of George Floyd have brought much-needed, urgent attention to the systematic racism that plagues all Black Americans. There are many things you can do with your time, energy, and money to support the Black Lives Matter movementprotest, call your elected officials, and donate. (We've got a list of places to consider right here.) One direct way to support the black community is to make an effort to buy directly from small business owned or founded by black entrepreneurs. To guide you, we put together a list 29 such brands spanning grooming, skincare, and wellness. (We've also got a separate list of fashion labels and clothing stores.) It's not a complete list, but it might help you spend thoughtfully the next time you need to refill your medicine cabinet.

Founded by certified aromatherapist Aba Gyepi-Garbrah, Aba Love Apothecary brings aromatherapy and skincare together using botanicals and other natural ingredients. Try the grooming oil, which softens your skin and beard in one go.

Dana Jackson started crafting skincare products out of a personal needshe was struggling with lupus, a chronic inflammatory disease, and needed gentle solutions she knew would work. Thus, her luxe line of scrubs and serums was born.

Founded in 2013 by Stanford graduate and Foursquare alum Tristan Walker, Bevel is a (GQ-loved) shaving company that focuses on minimizing razor bumps and irritation. (In 2018, Walker sold the company to Proctor & Gamble while staying on as CEO.)

Briogeo is a plant-based haircare line for all hair types. Founded in by Nancy Twine in 2013 while working in full-time in finance in New York City, Briogeo is now carried nationally at places like Sephora and SpaceNK.

Founded by D.C. native Patrick Boateng II, this simple, three-product line targets skin concerns many men of color faceacne, razor bumps, and hyperpigmentation.

Founded in 2016 by then-college student Joshua Esnard, The Cut Buddy helps you keep your lineup and beard looking fresh in between cuts. It was an Amazon best-selling grooming tool even before quarantine even began.

Founded by oculofacial plastic surgeon Chaneve Jeanniton, this tightly edited skincare line is full of hits. Chief among them is a stem-cell infused anti-aging serum dubbed "Master Plan".

Nigeria-born, England-based Ozohu Adoh started Epara to provide luxury skincare to people with dark skin tones. Using the best in highest quality African botanicals, the line targets concerns like dryness and discoloration.

Temi Shobowale started her namesake line after feeling disenchanted by the "cult loved" yet harmful products she was surrounded by in her beauty-retail career. Her plant-based line is simple, clean, and sustainable.

Whether you're into makeup or just curious about zit-covering options, Rihanna's Fenty Beauty has your back no matter your skin tone.

Named after founder Michael James's grandfather, Frederick Benjamin Grooming aims to replace heavy, harsh products for black hair and skin with gentler, more effective formulas. Pick up multiple products at once in the brand's regimen kits.

If you're curious about dry brushing and have Tom Ford-level taste, there's Gilded's marble-backed brush. Blair Armstrong's line has other super-luxe self-care goods too, from marble candles to super-rich body balms.

Cofounded by Trinity Mouzon Wofford and Issey Kobori, this Brooklyn-based wellness brand makes turmeric latte and matcha mixes and superfood-packed face masks so you can make a self-care night of it.

Desiree Verdejo founded Hyper after failing to find a serum that effectively treated the hyperpigmentation she experienced during pregnancy. Her vitamin-packed formula smoothes fine lines and softens skin at the same time.

Founded by esthetician and formulator Lesley Thornton, Klur is a luxe skincare line that promises results without the fuss. The packaging also happens to be display-it-on-the-sink-ledge good.

Co-founded by Queer Eye's Karamo Brown, Mantl's mission is to offer a "better bald" with products that clean, moisturize, and protect the face and scalp in one easy routine.

Jacob Quetant founded Nature Boy after noticing a lack of natural, gentle beard products on the market for men. The brand's deep cleaning Raw African Black Soap is the star of the showuse it on your face, beard, and body.

Founded by Richelieu Dennis, Nyema Tubman, and Mary Dennis in Harlem back in 1992, Nubian Heritage relies on natural, fair trade ingredients to make incredible-smelling soaps, aluminum-free deodorants, and body washes.

Named after the Yoruba word for queen, Olori is a Lagos-based haircare line formulated for African hair. Founded by Toyin Odulate, a personal-care industry veteran, Olori uses only natural ingredients.

This plant-based, paraben-free haircare line is specially formulated for cleansing, styling, and caring for dreadlocks.

Gianne Doherty and Jay Weeks's Organic Bath Co. is affordable, stylish, and all organic. Come for the body wash, stay for the hand sanitizer and face oil, leave without sticker shock.

If you've ever given side eye to disposable plastic razors or aggressively scented shave creams (everyone), Karen Young's stripped down, eco-conscious direct-to-consumer shaving brand is worth checking out.

Noticing a lack of organic products crafted for highly textured hair, Jamyla Bennu created Oyin, which uses nourishing honey to naturally smooth strands. No surprise: Oyin also makes a mean body lotion and beard softener.

Pattern makes hair products for the curliest, coiliest, and tightest of textures and was founded by Tracee Ellis Ross, our favorite person on Instagram.

Plant Apothecary, founded by Holly McWhorter and Bjarke Ballisager, makes a mean body wash and loads of other great-smelling certified organic skincare goods.

A board-certified dermatologist, Rose Ingleton's skincare line focuses on combatting common skin concerns like redness, dark spots, and wrinkles. And nice surprise: it's also totally natural.

Calvin Quallis's great-smelling beard products are a GQ favorite. Start there, but don't miss the hair and skincare offerings either.

Tatiana Price's shea-based, chemical-free body scrubs and lotions will whip your sad, stay-at-home skin right into shape. Buy in bulk. Scoop with abandon.

Founded by English celebrity hairstylist Vernon Franois, this luxe haircare line uses fair trade ingredients to create products for all hair types, from fine to coily.

Designer Aurora James's 15 Percent Pledge calls on big retailers to devote shelf space to historically underrepresented brands.

Visit link:
29 Black-Owned Grooming, Skincare, and Wellness Brands You Can Shop Right Now - GQ

United States, Florida, Miami 06-02-2020 (PRDistribution.com) MD Ageless Solutions is a multidisciplinary and a revolutionary medical spa. We specialize in regenerative and aesthetic medicine by using the newest and most innovative technologies.

We provide a variety of skin care treatments using the best and most efficient aesthetic treatments available. We use the latest scientific technologies and applications in treating skin problems and disorders. We provide the most advanced and painless skin treatments that you can only imagine.

We dont only have the best technologies, we also have highly experienced skincare professionals that work together to provide the best skin care treatments to all our clients. Our aim and goal is to provide and promote beauty and total skin wellness to our clients. We provide the best skin care services that you can find in Miami and around Florida.

Who is Yakelin Sosa

Dr. Yakelin Sosa, MD is a reputable and highly trained Anesthesiologist. She is certified in both aesthetics and advanced aesthetic treatments for aging skin and face. She is the CEO of MD Ageless Solutions Miami, Florida.

Dr. Sosa attended the University Of Puerto Rico School Of Medicine where she graduated Magna Cum Laude with her medical degree. She then went further to complete a 2 year residency training in Internal Medicine at Baylor College of Medicine in Texas.

Dr. Sosa has been in the field of aesthetics for over thirteen years and she is certified by the American Academy of Anti-aging Medicine. She has the leading training facility for aesthetic treatments in South Florida.

Dr. Sosa does not only have an excellent background in skincare treatments, she is also highly skilled and experienced in her field. She is very hardworking and continually incorporates the newest technologies into her practice. She is affiliated with several reputable and well-known medical organizations and bodies.

Benefits of Non-surgical Facelift and Neck lift

Nonsurgical facelift and neck lift are minimally invasive nonsurgical procedures used to rejuvenate and improve the appearance of your face and neck. The techniques used for nonsurgical facelift and neck lift do not require incisions, use of general anesthesia, or long stay at the hospital or clinic. There is no downtime with this technique and the side effects are very minimal. Nonsurgical facelift and neck lift techniques include the use of dermal fillers, botox and fat injections to rejuvenate, lift and improve the appearance of the face and neck.

Nonsurgical facelift and neck lift provides several benefits more than the surgical facelift and neck lift procedures. Instead of going through the rigorous, invasive and painful processes of surgical facelift and neck lift, it is best you opt for a simpler, noninvasive and painless facelift and neck lift procedure.

The benefits of nonsurgical facelift and neck lift include:

There are no downtime or recovery times Nonsurgical facelift and neck lift procedure require little or no downtime. After the treatment, you dont need to stay in the hospital for days because you can go back home immediately after the treatment. Also, you recover very fast after undergoing the treatment. You dont need to stay at home for weeks or months recovering from a nonsurgical treatment, unlike the surgical procedure whereby you may need to speed weeks or even months at home during recovery. You can still keep your appointments and continue your work after undergoing a nonsurgical facelift and face lift procedure.

It produces natural-looking and lasting results Nonsurgical facelift procedure involves the use of fillers, Botox and your own fat. The procedure does not involve incisions, unlike the surgical procedure that involves incision. Nonsurgical procedures use chemical substances that are found in your body to rejuvenate and improve the appearance of your facial skin and neck. It provides a more natural looking facial appearance than the surgical procedure. Also, there are no scars after undergoing a nonsurgical procedure.

It does not require the use of general anesthesia Nonsurgical facelift and neck lift treatments do not require the use of general anesthesia. This is a better option for people that are allergic to the substances used in producing the anesthesia. If you are allergic to any of the substances used in producing anesthesia, nonsurgical treatment is best for you.

The treatments are not as expensive as surgical procedures Nonsurgical facelift and neck lift procedure is relatively cheaper than surgical facelift and neck lift procedure. People who are on a budget can easily afford the nonsurgical facelift and neck lift treatment. Hence, it is better to opt for the nonsurgical option if you want to save costs.

It is faster Nonsurgical facelift procedures take a shorter time to be completed, unlike the surgical facelift and neck lift procedures. Surgical procedures require administration of general anesthetics, large incisions, and other things that take up a lot of time. You cannot go back to your job or continue with your activities for the day after undergoing surgical facelift and neck lift procedures but you can go back to your job or continue your activities for the day after undergoing nonsurgical facelift and neck lift procedures.

Patients experience little discomfort You dont experience pain or serious discomfort during or after nonsurgical facelift and neck lift procedures. The procedure doesnt involve large incisions; hence you only feel little or no discomfort. If you have a low threshold for pain, it is best you opt for nonsurgical facelift and neck lift treatment instead of the surgical procedure.

It helps to enhance facial looks and eliminate wrinkles Nonsurgical facelift and neck lift treatment helps to enhance your facial and neck appearance with ease. You can experience almost immediate results after undergoing nonsurgical facelift and neck lift treatment.

Fewer risks Surgical facelift and neck lift procedures involve more risks and complications but there are little or minor complications with the nonsurgical facelift and neck lift procedure. The risks and complications that you may experience during and after undergoing a surgical facelift and neck lift procedure far outweigh the risk of nonsurgical facelift and neck lift procedure. It is best to opt for a nonsurgical facelift and neck lift treatment if you dont want to experience serious side effects or complications.

Media Contacts:

Company Name: MD Ageless SolutionsFull Name: Dr Yakelin SosaPhone: Email Address: Send EmailWebsite: mdagelesssolutions.com

For the original news story, please visit https://prdistribution.com/news/md-ageless-solution-ceo-yakelin-sosa-shares-benefits-of-non-surgical-facelift-and-neck-lifting.html.

Powered by WPeMatico

Read more here:
MD Ageless Solution CEO Yakelin Sosa shares Benefits of Non-Surgical Facelift and Neck lifting - Life Pulse Health

Aesthetics devices are an innovative advancement, providing a solution to patients which deal with the ingenuity of creating beauty. The medical aesthetics devices is a growing market owing to its benefits such as maintaining the youthful appearance, pain free and non-invasive beauty treatments, maintenance free skin that remains smooth and hairless without the need for shaving, waxing or unpleasant hair treatments, improving the cosmetic appearance, and technological advancement in medical aesthetics devices.

Global Medical Aesthetics Market By Product type (Aesthetic Lasers, Energy Devices, Body Contouring Devices, Facial Aesthetic Devices, Aesthetic Implants, Skin Aesthetic Devices), Application (Anti-Aging and Wrinkles, Facial and Skin Rejuvenation, Breast Enhancement, Body Shaping and Cellulite, Tattoo Removal, Vascular Lesions, Psoriasis and Vitiligo, Others), End User (Cosmetic Centres, Dermatology Clinics, Hospitals, Medical Spas and Beauty Centres), Distribution Channel (Direct Tender, Retail), Geography (North America, South America, Europe, Asia-Pacific, Middle East and Africa) Industry Trends and Forecast to 2026

Global medical aesthetics marketis projected to register a healthy CAGR of 12.1% in the forecast period of 2019 to 2026.

Get Sample Report + All Related Graphs & Charts @https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-medical-aesthetics-market

The market is showing a substantial growth in the emerging countries as these countries are adapting to the trends of urbanization. Brazil, South Africa, Thailand and many others have improved in the past one decade. People are opting different aesthetics surgeries to maintain themselves, which give them better results without any stressful physical efforts. Medical Aesthetics is one of the most trending concepts of the 21stCentury which will show a substantial increase in the future as there is a great technological advancement and innovation in the field by the companies dealing with these devices making them safer and even less invasive leading to more population opting for these procedures.

Competitive Analysis: Global Medical Aesthetics Market

Some of the major players operating in the global medical aesthetics market are Allergan, Bausch Health Companies Inc., Lumenis, Shanghai Fosun Pharmaceutical Group Co. Ltd., Cynosure, Syneron Medical Ltd, Aerolase Corp., A.R.C. Laser Gmbh, Asclepion Laser Technologies Gmbh, Btl, Cutera, Eclipse, Lutronic, Mentor Worldwide Llc, Merz Pharma, Quanta System, Sciton Inc., Sharplight Technologies Inc, Syneron Medical Ltd., Venus Concept.

Segmentation: Global Medical Aesthetics Market

Global medical aesthetics market is segmented into 4 notable segments such as product type, type of care, accessories and end user

Grab Your Report at an Impressive 30% Discount! Please click[emailprotected]https://www.databridgemarketresearch.com/request-a-discount/global-medical-aesthetics-market

Product Launch:

Allergan

The company was founded in 2013 and headquartered at Dublin, Ireland. The company is focused on developing, manufacturing and commercializing branded device, biologic, pharmaceutical, surgical and regenerative medicine products for patients throughout the world. The main business segments are US Specialized Therapeutics, US General Medicine, International. The revenue of the company in healthcare sector 2018 was USD 16,550.8 Million. The company has global presence in North America, Asia Pacific, South America, Europe and Middle East & Africa.

Access Full Report athttps://databridgemarketresearch.com/reports/global-medical-aesthetics-market/

Bausch Health Companies Inc.

The company was founded in 1959 and headquartered at Quebec, Canada. The company is engaged in manufacturing and marketing a broad range of branded and generic pharmaceuticals, over-the-counter (OTC) products and medical devices. The main business segments are Bausch + Lomb/International, Branded Rx, U.S. Diversified Products. The revenue of the company in healthcare sector 2018 was USD 8,174.8 Million. The company has global presence in North America, Europe, the Middle East, Africa, Asia Pacific and Latin America.

Luimenis

The company was founded in 1991; headquarter in Yokeneam, Israel. The company is engaged in the field of minimally-invasive clinical solutions for the Surgical, Ophthalmology and Aesthetic markets, and expert in developing and commercializing innovative energy-based technologies, including Laser, Intense Pulsed Light (IPL) and Radio-Frequency (RF). The company has global presence in North America, South America, Europe, Asia, Africa and Australia.

Note: If you have any special requirements, please let us know and we will offer you the report as you want.

About Data Bridge Market Research:

Data Bridge Market Researchset forth itself as an unconventional and neoteric Market research and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best market opportunities and foster efficient information for your business to thrive in the market. Data Bridge endeavors to provide appropriate solutions to the complex business challenges and initiates an effortless decision-making process.

Contact:

Data Bridge Market Research

US: +1 888 387 2818

UK: +44 208 089 1725

Hong Kong: +852 8192 7475

Email:[emailprotected]

Excerpt from:
COVID-19 UPDATE: Medical Aesthetics Market 2020 Emerging Technology, Opportunities, Analysis and Future Threats with Key Players like Allergan, Bausch...

As coronavirus-induced mortality rates feature persistently in the nightly news, life feels more fleeting and fragile than before. Yet Israeli and Azerbaijani researchers are among those investigating the secrets behind longevity.High in the mountain forests of Eurasias Caucasus region and down in the leafy lowlands of Azerbaijan, clusters of superagers generally those age 90 and above have inspired generations of documentarians and scientists alike to plumb the mysteries of living a long life.Storytellers long have circulated tales of groups of Azerbaijanis living to be more than 120; a museum in the city of Lankaran honors the countrys long livers. Since the 1970s, Azerbaijans overall life expectancy has settled into the global-average range of 71. Still, an unusual number of Azerbaijanis, primarily in remote areas, have overwhelmingly defied the average.What exactly affords Azerbaijans superagers the ability to keep on living?ClustersWhy have clusters of superagers not just isolated superagers appeared in Azerbaijan and elsewhere in the world? Genes and family history come into play. Looking at the clusters in Azerbaijan may add to the body of knowledge of medical factors and family patterns that proactively contribute to longevity.A growing number of scientists consider aging to be a preventable condition that can be addressed by gene therapy. Such an approach contrasts with the medical communitys traditional focus on the risk factors that pose impediments to long life. Lessons to be learned from Azerbaijan and elsewhere may contribute to our ability to prolong life.GeneticsThe New York-based Albert Einstein College of Medicines Dr. Nir Barzilai, an eminent leader in longevity research, has not personally examined the Azerbaijani case but points to his long-term research on Ashkenazi Jews in discussing the issue of clusters.Israeli-born Barzilai, founding director of the colleges Institute for Aging Studies and scientific director of the American Federation for Aging Research, has identified or corroborated longevity-associated gene markers that include the cholesteryl ester transfer protein gene (CETP). In one form, CETP correlates with slower memory decline, lower dementia risk, and significant protection against heart disease. CETPs appearance is affiliated with higher good cholesterol (HDL). Scientists and pharmaceutical companies such as Merck have looked to CETP and other identifying markers as means to interrupt age-related diseases.Barzilais study of the largely homogeneous Ashkenazi Jewish population has revealed shared genetic elements resulting in patterns. The research has helped Barzilai and others develop mitochondria-based therapeutics for diseases associated with aging.LifestyleLifestyle matters, scientists and laypeople generally agree. Whether it be taking daily walks or turning off the news, people who live a life focused (but not overly focused) on healthy habits tend to live longer.Dr. Anatoly Khaimovich Rafailov, a surgeon with more than 40 years of experience who leads the Azerbaijan-Israel Inter-Parliamentary Work Group in the Azerbaijani Parliament, attributes the high life expectancy in some regions of Azerbaijan to two factors. First: the residents of those regions widely use Berberis (Barberry) in their everyday meal. The anti-oxidant, anti-inflammatory, and other healing properties of Berberis are well-known since ancient times, he says. The second factor is that people there are very active physically daily, they walk about 18-20 kilometers (11-12 miles). And motion is life.Many Azerbaijanis cite a diet centered on unprocessed, organic foods and a lack of involvement in harried debate as keys to long life. Dr. Tahir Amiraslanov, president of the Azerbaijan National Culinary Association and editor-in-chief of the Kulina scientific journal, says, People eat what they grow, use clean water and fresh air, live in a house with a large, multigenerational family, and overall live a natural life and try to do good things.Professor Ulduz Hashimova, director of the Institute of Physiology at the Azerbaijan National Academy of Sciences in the countrys capital of Baku, shares that her institute has made understanding superaging an institutional priority for several years. The institutes comprehensive research has spanned disciplines, from genealogy to ecology, neurology, biochemistry, and beyond. Most published works deriving from this effort are written in Russian, which may partially explain the Wests general lack of familiarity with this research.From the pandemic to the futureAzerbaijan has fostered significant partnerships in the humanities and other disciplines, and the West is building an understanding of Azerbaijani culture and contributions. Amid the pandemic and in the coming years, the US scientific community may look to Israel and Azerbaijan who are partners in technical and other arenas for breakthroughs in the understanding of aging.The Azerbaijani superaging phenomenon may also be of particular interest to social scientists, given major societal changes during the past century. Consider this: Someone over the age of 100 might have witnessed what is now the Republic of Azerbaijan as a portion of the Russian Empire, a part of the early Azerbaijani Democratic Republic, and as an S.S.R. of the Soviet Union.As societies become increasingly heterogeneous, we can learn from families and communities with shared characteristics. We may unlock more life-extending therapies. Meanwhile, as research progresses, we can make the lifestyle changes already identified as keys to longevity.Diana Cohen Altman, principal of Cultural Diplomacy Associates, L.L.C., and former executive director of the US cultural non-profit Karabakh Foundation, writes extensively about Azerbaijani cultural and civil-society topics.

Go here to see the original:
Do Azerbaijan and Israel possess the secrets of a long life? - The Jerusalem Post