Category Archives: Anti-Aging Medicine

BEVERLY HILLS, Calif., June 25, 2012 (GLOBE NEWSWIRE) -- OXIS International, Inc. (OXIS) (OXI.PA) today announced the international commercial launch of its proprietary, clinically proven, joint health product, ErgoFlex(TM) (www.ergoflexbest.com). A study published last month in the peer reviewed journal of Preventive Medicine clearly demonstrated ErgoFlex's ability to reduce pain, increase range of motion and significantly improve the quality of life from people who suffer from joint pain.

Unlike any other antioxidant available to consumers, our catalyst ingredient in ErgoFlex, EGT, is referred to as the "intelligent antioxidant" because it is the only antioxidant having a dedicated transport mechanism in the body to deliver it through the cell membrane and even into the mitochondria, the energy producing area of the cell. Additionally, when other powerful antioxidants are also present, the body preferentially utilizes ergothioneine.

OXIS holds the exclusive patent to manufacture EGT, which has received full GRAS (safety) approval. OXIS' marketing partner, engage:BDR, has been developing a comprehensive, full digital advertising campaign for a pipeline of OXIS' proprietary EGT(TM) dietary supplements and anti-aging personal care products.

"This is a major step forward in demonstrating the company's focus of delivering our proprietary EGT(TM) based products direct to consumers. Our partners at engage:BDR have an outstanding track record executing on direct-to-consumer product campaigns and ability to deliver our product message to a much-targeted audience that will make for a very successful launch. I am anticipating significant revenue ramp-up with ErgoFlex with additional products to follow soon," said David Saloff, Chairman and CEO of OXIS International.

"OXIS International's team has demonstrated tremendous expertise in product development, one such being the EGT product line which we're extremely excited to deliver to the market," said Ted Dhanik, president, engage:BDR.

About OXIS International, Inc.

OXIS International, Inc. develops technologies and products to research, diagnose, treat and prevent diseases of oxidative stress/inflammation associated with damage from free radical and reactive oxygen species (ROS). The company holds the rights to several therapeutic classes of compounds in the area of oxidative stress, including EGT(TM) (99% pure L-ergothioneine), known as the intelligent antioxidant.

About engage:BDR

engage:BDR provides advertisers cutting-edge marketing solutions, advanced technology and custom programming by integrating display, video and branded entertainment into a single network. Whether it's driving qualified traffic and leads or building awareness and engagement, engage:BDR is committed to providing innovative solutions to reach consumers and deliver the highest quality results to their partners. Headquartered in Los Angeles, engage:BDR attracts a list of top name partners and customers including Ask.com, Bose, CBS Interactive, eHarmony, Live Nation, Sony Pictures among others.

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OXIS Announces the International Launch of Online Sales for ErgoFlex(TM)

Eating too much sugar certainly isnt wise for your waistline, but did you know that overindulging in dessert can add years to your face? And even if you do strenuous cardio workouts each week, youll be missing out on potential anti-aging body benefits if your schedule doesnt include yoga, weight training and rest.

Find out if youre making one of these eight common diet and exercise mistakes, and get smart prevention strategies that can keep you slim and youthful for years to come.

1. You Overdo Dessert

The breakdown of sugars, called glycation, damages the collagen that keeps skin smooth and firm. To prevent this natural process from careening out of control, Dr. Naila Malik, a dermatologist in Southlake, Texas, sticks to low-glycemic carbs like whole grains. Theyre naturally low in sugar, and the body processes them slowly to limit the loss of collagen. If you want to sweeten up your tea or oatmeal without making your skin look older, try all-natural stevia. Its an easily digested herbal sweetener that doesnt trigger glycation, according to board-certified dermatologist Dr. Nicholas Perricone, an adjunct professor of medicine at Michigan State Universitys College of Human Medicine.

2. You Spin Away Stress

Taking your work angst out on the bike or treadmill might make you feel better for a little while, but incorporating yoga into your fitness routine regularly may help you look younger and prevent breakouts while whittling away stress. Sounds like a winning workout to us! Yoga moves like childs pose, downward-facing dog and sun salutations improve circulation the boost of oxygen is what gives skin that lovely yoga glow, says Dr. Hema Sundaram, a Washington, D.C., dermatologist. New research finds regular yoga practice may reduce the inflammation and stress that speed skin aging. If you need another reason to om away your stress: High levels of tension can spike hormone production that leads to breakouts or aggravates conditions like psoriasis. Controlling stress keeps your skin calm, says Dr. Annie Chiu, a dermatologist in Los Angeles.

3. You Always Choose Coffee Over Tea

Research suggests that green and black tea contain protective compounds like EGCG and theaflavins that help prevent skin cancers and the breakdown of collagen, the cause of wrinkles.

4. You Pretend to Be Allergic to Dumbbells

Following a regular strength-training routine that creates better, more supportive muscle tone will help you firm sagging skin from the neck down. I am religious about strength-training, and I always tell patients to do it more as they get older, says Dr. Patricia Farris, a dermatologist in Metairie, La. Its like adding volume to the face with fillers, except on your body, says Farris.

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8 diet and exercise mistakes that age you

VANCOUVER, British Columbia--(BUSINESS WIRE)--

ProtoKinetix (PKTX) (www.protokinetix.com) announces the formation of a new structure that allows the Company the flexibility of financing through a subsidiary, partnering through a subsidiary or selling the subsidiary. These new entities will contain rights to clearly defined AAGP applications that can easily be segregated from the overall asset base.

Due to recent discussions and testing, the first subsidiary to be formed will be for the large (estimated to be $40 to $50-Billion annually worldwide and growing) monoclonal antibody production market. Those rights will have significant value in increasing the productivity of hybridoma cells which make monoclonal antibodies. In one test AAGP increased the production of antibodies by 300% and in another test by 500%.

AAGP bio assays (which can be viewed at our revised web site) show that AAGP has an important role in Regenerative Medicine. Regenerative Medicine is the process of replacing or regenerating human cells, tissues or organs to restore or establish normal function and is becoming one of the largest growth industries in healthcare.

ProtoKinetix anticipates the requirement to establish several subsidiaries to maximize the financial returns for its shareholders.

About ProtoKinetix

ProtoKinetix, Inc. is a biotechnology company that has developed and patented a family of synthetic anti-aging glycopeptides (AAGP) for medicine and the biotechnology and cosmetic industries. PKTXs primary focus is on the therapeutic potential for AAGP in the treatment of Diabetes, inflammatory diseases, skin protection and anti-aging.

The Private Securities Litigation Reform Act of 1995 provides a safe harbor for forward-looking statements. Some information included in this press release contains statements that are forward-looking. Such forward-looking information involves significant risks and uncertainties that could affect anticipated results in the future and, accordingly, these results may differ materially from those expressed in any forward-looking statements made by or on behalf of the Company. For a description of additional risks and uncertainties, please refer to the Companys filings with the Securities and Exchange Commission.

Ross L. Senior President and CEO

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ProtoKinetix Creates Subsidiaries for AAGP™ Applications to Maximize Shareholder Value

SCOTTSDALE, Ariz. & LOS ANGELES--(BUSINESS WIRE)--Makucell, Inc., a pioneering regenerative biotechnology company dedicated to the development, manufacture and distribution of non-prescription products formulated to address the impact of aging and photo-damaged skin unveils the Renewnt (pronounced Re-new-int) brand, a revolutionary science-driven product line. Renewnts proprietary ingredient, Asymmtate, is a new approach to cellular aging, optimizing signals in the Wnt (pronounced wint) pathway to energize the skins stem cells, encouraging youthful cell behavior. The result is younger-looking skin which appears firmer and smoother. This molecular process is the key to our proprietary technology developed at USCs Keck School of Medicine and transferred to Makucells Renewnt skin care line.

Renewnt delivers extraordinary regenerative ability in a hydrating cream, providing an advanced anti-aging option. Asymmtate in Renewnt wakes-up the skins stem cells which have become sluggish with age, to begin rebuilding the underlying supporting skin matrix. As a result, skin looks plumper and has a rejuvenated, youthful appearance.

The Makucell Science

The bodys signals govern skin stem cells, controlling the decision to remain dormant, divide or differentiate (become normal, active tissue cells). Signals flow in pathways and multiple paths converge into one the Wnt pathway. Makucells proprietary molecule Asymmtate encourages optimal signaling in the Wnt pathway. Optimal signaling stimulates the skin stem cells to begin the process leading to keratinocytes, fibroblasts and other dermal cells which produce collagen, elastic tissue and substances in the supporting skin matrix. This essential regenerative process is the key differentiator in Makucells Renewnt skin care products.

Michael Kahn, Ph.D. and his team of gifted research scientists at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research of the Keck School of Medicine at the University of Southern California developed the revolutionary ingredient, Asymmtate, Makucells core technology. Dr. Mark V. Dahl, Makucell Chief Medical Officer and former President of the American Academy of Dermatology as well as Professor Emeritus at the Mayo Clinic in Arizona, developed the formulations designed to target a specific skin type on a particular area of the body. Makucell has tested all the Renewnt products for safety and efficacy. The products:

Makucell is committed to supporting our claims with results from controlled, blinded studies, explains Dr. Dahl. We conducted standard industry safety tests, and the results were universally positive; Renewnt products were well tolerated with no adverse effects or safety issues. A combination of clinical trials and in vitro gene expression studies from treated biopsied skin continues to corroborate the aesthetic effects noted in the clinic.

Dr. Lawrence Rheins, President and Chief Executive Officer of Makucell, commented, Renewnt delivers extraordinary regenerative ability in a hydrating cream, providing an advanced anti-aging option. Asymmtate in Renewnt wakes-up the skins stem cells which have become sluggish with age, to begin rebuilding the underlying supporting skin matrix. As a result, skin looks plumper and has a rejuvenated, youthful appearance.

Makucells current Renewnt skin care product line includes:

Renewnt for Hydration, a day and night facial moisturizer for a more youthful-looking appearance.

Renewnt for Strength, for the dry, thinning skin on hands and forearms to seal in moisture, repair the signs of aging and restore the essential skin barrier.

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Makucell Unveils Renewnt™, a Revolutionary, Science-driven Skin Care Brand

NEW YORK, June 20, 2012 /PRNewswire/ --Bruce E. Katz, M.D., Clinical Professor of Dermatology at Mount Sinai School of Medicine, Director of the Cosmetic Surgery & Laser Clinic at Mount Sinai Medical Center and Director of JUVA Skin & Laser Center in New York has just been named one of the Top Doctors by Castle Connolly and featured in New York Magazine's Best Doctors list.

Dr. Katz is a leading innovator of advanced laser technology and skin rejuvenation techniques. As a pioneer of the latest breakthrough in long-term cellulite treatment, Cellulaze, along with his work with anti-aging treatments such as the Madonna Lift (fractional eyelift) and body contouring breakthroughs like SmartLipo, Dr. Katz has earned this prestigious distinction for the seventh time.

At the JUVA Skin & Laser Center Dr. Katz oversees a team of skilled clinicians who treat all dermatological diseases, conditions and cosmetic imperfections with the latest laser technology. The Body Contouring Center at JUVA is a full-service retreat offering the latest technological advances in non-invasive and minimally invasive body contouring techniques treating a wide variety of body issues from unwanted body fat, skin tightening and breast enlargement. In addition to its extensive laser surgery capabilities, the JUVA Skin & Laser Center is AAAHC accredited and offers medical spa services and anti-aging skin care products designed for home use.

Castle Connolly Medical Ltd. is a New York City research and information company that publishes an annual guidebook titled Top Doctors: New York Metro Area, which lists those whom Castle Connolly has determined to be in the top 10 percent of the region's physiciansmore than 5,600 in all. For the past fifteen years, Castle Connolly has been providing New York Magazine with a shorter version of this list for the magazine's Best Doctors issue.

To request an interview with Dr. Katz please contact Alexis Tedesco of Lexamedia at 347.830.4004 / alexis@lexamediapr.com

For more information about JUVA Skin & Laser Center or the Body Contouring Center at JUVA please visit http://www.juvaskin.comor call 212.688.5882. Please visit us on Facebook at facebook.com/juvanyc to learn more about our recent media appearances and updates.

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Dr. Bruce Katz Named Top Doctor By Castle Connolly

Consumers often spend hundreds and sometimes thousands of dollars a year on skin care products in an effort to improve the look of their skin. From anti-aging serums to acne medications, many adults and teens regularly apply medications or treatments to their skin. But does the sequence in which skin care products are applied influence how well the products work? Dermatologists say yes.

"Medications or treatments should be applied directly after washing your face," said board-certified dermatologist Susan C. Taylor, MD, FAAD. "This ensures that the medications or treatments are properly absorbed by the skin. Otherwise, people may think a product isn't working because it's applied in the wrong order."

To maximize the effectiveness of skin care products, Dr. Taylor recommended people take the following steps when caring for their skin:

Wash your face. Use a gentle cleanser and gently pat dry.

Apply medication or treatment. If you are using a medicine or other treatment on your skin, you should apply this right after cleansing unless otherwise recommended by your dermatologist. When applying any cream around your eyes, use your ring finger, as it is the weakest finger and will not pull too hard on this delicate skin.

Apply moisturizer and/or sunscreen. Apply makeup, if desired. "It's important for people to know that using several products at the same time may not only negate the benefits of each product but also irritate the skin," said Dr. Taylor. "Using too many products may cause redness, stinging and dryness of the skin, especially if an anti-aging product is included. The signs of aging may then be more noticeable. A dermatologist can address any questions or concerns that you have about caring for your skin." These steps are demonstrated in "Get the Most from Your Skin Care Products," a video posted to the Academy website and the Academy's YouTube channel. This video is part of the Dermatology A to Z: Video Series, which offers relatable videos that demonstrate tips people can use to properly care for their skin, hair and nails. A new video in the series will be posted to the Academy website and the YouTube channel each month. Headquartered in Schaumburg, Ill., the American Academy of Dermatology (Academy), founded in 1938, is the largest, most influential, and most representative of all dermatologic associations. With a membership of more than 17,000 physicians worldwide, the Academy is committed to: advancing the diagnosis and medical, surgical and cosmetic treatment of the skin, hair and nails; advocating high standards in clinical practice, education, and research in dermatology; and supporting and enhancing patient care for a lifetime of healthier skin, hair and nails. For more information, contact the Academy at 1-888-462-DERM (3376) or http://www.aad.org. Follow the Academy on Facebook (American Academy of Dermatology) or Twitter (@AADskin).

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Get the Most From Your Skin Care Products