But despite rounds of surgery and radiation and chemotherapy, the cancer kept coming back. Eventually, her prognosis shifted from very hopeful to very dim, Christine says. (Here are 8 things every woman needs to know about ovarian cancer.)
I had two young children and I was being told, basically, to get my affairs in order, she says. I was not given much hope. In fact, Christine was told she had around a month of "good-quality life" left to live.
It was around this time, early 2014, that her doctor at Cancer Treatment Centers of America proposed genomic testing. I had never heard of this form of testing before, she says. It was completely new to me. Considering the bleakness of her prognosis, she was excited to hear she had a hopeful new option.
Considering where I was, to be able to live a normal life and look forward to watching my kids grow up is amazing.
Her doctors sent her tumor cells to the labs of Foundation Medicine. Their tests identified mutations within the DNA of Christines tumor cells that indicated she might respond well to a targeted drug therapy called everolimus (trade name Antifor), which is normally used to treat renal (or kidney) cancer. She started on everolimus in 2014.
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It was a drug interventionI take a pill every day with a glass of water, she says. After three years on the drug, her cancer has retreated: Ive had completely clear scans and my cancer is in remission."
I never would have thought this was possible, she adds of the seemingly miraculous outcome. Considering where I was, to be able to live a normal life and look forward to watching my kids grow up is amazing.
What Is Genomic Testing?Every cell in your body contains 20,000 to 30,000 genes. By examining those genes for abnormalities or mutations, genetic testing can determine if the makeup of your DNA puts you at greater risk for certain types of cancer. (This is what it's like to be tested for the breast cancer gene.)
The test offered by Foundation Medicine and other genomic testing companies is slightly different in that it also examines the genetic makeup of tumor cells.
By sequencing the genes within a persons tumor cells, the test can in some cases identify mutations that may respond to new and more-targeted treatment options, says Kojo Elenitoba-Johnson, MD, a professor of pathology and laboratory medicine and director of the Center for Personalized Diagnostics at the University of Pennsylvania Perelman School of Medicine.
MORE: 7 Warning Signs Of A Brain Tumor You Should Know
Genomic testing can also eliminate treatment optionsan outcome Elenitoba-Johnson says is also useful. This can prevent wasteful and counterproductive treatment courses, and it saves critical time that may be wasted in applying the wrong therapy, he explains.
Watch this moving video of strangers talking about their metastatic breast cancer:
It's important to note that, while drug companies are developing new treatments all the time, drugs do not exist for every genetic mutation, he adds. There are many more mutations than there are therapies at this point. Whether or not insurance will pay for the test or treatments also depends on the specifics of your situation and coverage.
PREVENTION PREMIUM: The One Thing That Got Me Through Cancer And A Divorce
Another Success StoryLike Christine Schmidt, Colleen Farrell was youngjust 33when she was first diagnosed with cancer.
In the summer of 2014, Id started feeling run down, she recalls. I started napping every day, which was totally unlike me, and I had discomfort in my lower back.
Doctors initially pegged her discomfort as a pulled muscle. But by that fall, they had identified a tumor. Colleen had advanced colorectal cancer. (Every woman should know these 5 signs of colorectal cancer.)
I was Stage 4, so it was bad, she recalls. It wasnt quite, Go home and plan your funeral, but it was, Be aware that you might have to soon.
MORE:7 Things That Surprised Me About Going Through Chemotherapy
Despite radiation and chemo, the cancer soon spread to her liver and both her lungs. I was blown awayjust devastated, she says. Things were very grim.
The images came back showing that not only had the tumors not grown, but theyd started to recede.
Her doctors told her about genomic testing, and that it could open doors to new treatment options. They told me some people were having success, but there were a lot of unknowns, she recalls. I asked what my odds were without it, and they told me a couple of months, so I obviously wanted to try it.
The results her doctors got back from Foundation Medicine indicated her cancer might respond to immunotherapy (here's how it works). I started it in March of 2016, she says. Eight weeks later, I had my first scan, and the images came back showing that not only had the tumors not grown, but theyd started to recede.
She says her doctor was floored. Back when her rectal tumor had first been discovered, it had measured 12 centimeters. After just one course of the new treatment, it had shrunk to 7 cm. My doctor couldnt believe how well it was working, she says.
MORE: 11 Women Share The Surprising Ways They Discovered They Had Cancer
In fact, the new medication almost worked too well. I ended up having three massive hemorrhages and almost died because my tumor shrank so quickly that all the blood vessels and organs that were smushed up suddenly started pumping blood again, she says. So that tells you how quickly it worked.
Colleen says shes not completely out of the woods. But I never thought Id be where I am today, she adds. I think all the time how lucky I was to have benefited from thisthat I could try itbecause not everybody can.
Whos A Candidate For Genomic Testing?As recently as a few years ago, the type of gene sequencing performed during this test would have cost millions of dollars and taken years, not days, to complete, Elenitoba-Johnson says.
Because the genomic testing platform is so newand many of the associated treatment options are still in clinical trialsgenomic testing may only be appropriate when conventional approaches like chemotherapy have failed, he says. (Here are 5 misconceptions you probably still have about chemo.) It really depends on the type of cancer a person has.
For some forms of leukemia, the knowledge of the disease response is pretty mature, and so the first-line management is receiving this test and one of these new targeted therapies, he explains. In other cases, drugs [targeting the mutations] have only recently become available, and knowledge of their effectiveness and side effects is not as well-understood.
He mentions lung cancer, colorectal cancer, and melanoma as other forms of cancer for which genomic testing may be appropriate. But again, it depends on the individual patient and the specifics of their cancer.
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Needless to say, the science of cancer diagnostics and treatment has entered a new and exciting phase. Genomic testing, coupled with newer, more-targeted therapies, is already saving lives.
The future is here, and it is bright. But theres a lot more work to be done.
The rest is here:
This Last-Resort Test Saved 2 Women From CancerAnd It Could Save You, Too - Prevention.com
Recommendation and review posted by G. Smith
