Initiating metformin soon after diabetes diagnosis and while A1C is low might preserve ?-cell function, prolong the effectiveness of metformin, reduce lifetime glycemic burden, and prevent diabetes complications.
These findings support the current treatment algorithm for hyperglycemia management that recommends metformin initiation when diabetes is first diagnosed.
Video: How the Body Works - The Pancreas.
References:
Secondary Failure of Metformin Monotherapy in Clinical Practice. Diabetes Care March 2010 vol. 33 no. 3 501-506.
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Recommendation and review posted by G. Smith
