Dedication
List of Contributors
Preface
Chapter 1. Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications
Objectives
Introduction
Cytochrome P-450 Enzymes
Non-CYP-450 Drug Metabolizing Enzymes
Polymorphisms in Drug Transporter Genes
Drug Target Genes
Conclusion
Questions for Discussion
References
Chapter 2. Translating Pharmacogenomic Research to Therapeutic Potentials
Objectives
Introduction
Implementation of Biomarkers in Clinical Practice
Incorporating Pharmacogenomics intoDrugDevelopment
Conclusion
Questions for Discussion
References
Chapter 3. Governmental and Academic Effortsto Advance the Field ofPharmacogenomics
Objectives
Introduction
The Role of the National Institutes of Health
The Role of the Food and Drug Administration and OtherInternational Government Agencies
Activities of Non-U.S. Agencies
Conclusion
Questions for Discussion
References
Chapter 4. Pharmacogenomics in Cancer Therapeutics
Objectives
Introduction
Role of Oncology Biomarkers
Concepts in Targeted Cancer Therapy
Oncology in the Postgenomic Era
Challenges in Drug Development and Cancer Trials
Seeking Pharmacogenomic Value
Questions for Discussion
References
Chapter 4A. A Look to the Future: CancerEpigenetics
Learning Objectives
Introduction
Histone Modification
DNA Methylation
Noncoding RNA (ncRNA)
Conclusion
Questions for Discussion
References
Chapter 5. Pharmacogenetics in Cardiovascular Diseases
Objectives
Introduction
Pharmacogenomics of Antiplatelet Agents
Warfarin Pharmacogenomics
Other Genetic Contributions to Warfarin Dose Variability and Response
Trials and Tribulations of Pharmacogenomics of Agents Used to Treat Dyslipidemia
Pharmacogenomic Potential in Heart Failure
Genetic Influences of Drug-Induced Arrhythmia
Conclusion
Discussion Points
Discussion Questions
References
Chapter 5A. A Look to the Future: Cardiovascular Pharmacoepigenetics
Learning objectives
Introduction
Opportunities
Challenges
Conclusion
Questions for Discussion
References
Chapter 6. Pharmacogenomics in Psychiatric Disorders
Objectives
Introduction
Polymorphisms in Proteins that Affect Drug Concentrations
Polymorphisms in Proteins that Mediate Drug Response
Application of Pharmacogenomics in Psychiatry
Conclusion
Questions for Discussion
References
Chapter 6A. A Look to the Future: Epigenetics in Psychiatric Disorders and Treatment
Objectives
Nature and Nurture Both Contribute to the Etiologies of Psychiatric Disorders
Epigenetic Processes Are Likely to Contribute to the Biochemical Basis of Nurture
Epigenetic Dysfunction Has Been Linked to Psychiatric and Neurological Disorders
Epigenetic Processes May Be Critical to Treatment Response in Psychiatric Disorders
Epigenetic Variation of Genes Regulating Pharmacokinetic Processes Is Likely to Influence Treatment Response
Epigenetic Modifications of Drug Transporters
Epigenetics and Adverse Drug Reactions
Limitations of Epigenetic Biomarkers in Psychiatry
Conclusion
Questions for Discussion
References
Chapter 7. The Role of Pharmacogenomics in Diabetes, HIV Infection, and Pain Management
Objectives
Introduction
Diabetes Overview
Type 2 Diabetes Pharmacogenomics
Challenges and Opportunities of Pharmacogenomics in Diabetes
Pharmacogenomics and HIV
Pharmacogenomics and Pain Control
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Pharmacogenomics - 1st Edition - Elsevier
Recommendation and review posted by G. Smith
